Faculty Profiles - Koji Nishiguchi

Papers - Koji Nishiguchi

Division display 1 - 20 of about 146 ／ All the affair displays >>

Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation. Reviewed

Nature Vol. 427 ( 6969 ) page： 75-78 2004

Novel mutations in the cellular retinaldehyde-binding protein gene (RLBP1) associated with retinitis punctata albescens: evidence of interfamilial genetic heterogeneity and fundus changes in heterozygotes Reviewed

Fishman GA, Roberts MF, Derlacki DJ, Grimsby JL, Yamamoto H, Sharon D, Nishiguchi KM, Dryja TP

Arch Ophthalmol Vol. 122 ( 1 ) page： 70-75 2004

Mutation screening of the phosducin gene PDC in patients with retinitis pigmentosa and allied diseases Reviewed

Mol Vis Vol. 10 page： 62-64 2004

A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration Reviewed

Vol. 45 page： 3863-3870 2004

Recessive NRL mutations in patients with clumped pigmentary retinal degeneration and relative preservation of blue cone function Reviewed

Nishiguchi KM, Friedman JS, Sandberg MA, Swaroop A, Berson EL, Dryja TP

Vol. 101 page： 17819-17824 2004

Cone cGMP-gated channel mutations and clinical findings in patients with achromatopsia, macular degeneration, and other hereditary cone diseases Reviewed

Vol. 25 page： 248-258 2005

Recessive mutations in the CYP4V2 gene in East Asian and Middle Eastern patients with Bietti crystalline corneoretinal dystrophy Reviewed

Lin J, Nishiguchi KM, Nakamura M, Dryja TP, Berson EL, Miyake Y

J Med Genet Vol. 42 2005

Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity Reviewed

Hum Mutat Vol. 28 page： 589-598 2007

*The role of VEGF and VEGFR2/Flk1 in proliferation of retinal progenitor cells in murine retinal degeneration Reviewed

Vol. 48 page： 4315-4320 2007

*Identification of photoreceptor precursors in the pars plana during ocular development and after retinal injury Reviewed

Nishiguchi KM, Nakamura M, Kaneko H, Kachi S, Terasaki H

Invest Ophthalmol Vis Sci Vol. 49 page： 422-428 2008.1

*Characteristics of Bone Marrow-Derived Microglia in the Normal and Injured Retina Reviewed

Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Terasaki H

Vol. 49 page： 4162-4168 2008.9

*Retardation of Photoreceptor Degeneration in the Detached Retina of rd1 Mouse Reviewed

Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Terasaki H

Invest Ophthalmol Vis Sci Vol. 49 page： 781-787 2008.2

TRPM1 mutations are associated with the complete form of congenital stationary night blindness Reviewed

Nakamura M, Sanuki R, Yasuma TR, Onishi A, Nishiguchi KM, Koike C, Kadowaki M, Kondo M, Miyake Y, Furukawa T.

Mol Vis Vol. 16 page： 425-437 2010

Regulation of pathologic retinal angiogenesis and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate. Reviewed

Nishiguchi KM, Kataoka K, Kachi S, Komeima K, Terasaki H

PLoS ONE Vol. 5 page： e13493 2010

The roles of vitreal macrophages and circulating leukocytes in retinal neovascularization. Reviewed

Kataoka K, Nishiguchi KM, Kaneko H, van Rooijen N, Kachi S, Terasaki H

Invest Ophthalmol Vis Sci Vol. in press 2010

Evaluation of retinal arterioles in retinitis pigmentosa: Arterial lumen diameter reduced with retinal degeneration and wall thickness related to systemic condition

Junya Ota, Taiga Inooka, Ryo Tomita, Taro Kominami, Yoshito Koyanagi, Yasuki Ito, Hiroko Terasaki, Koji M Nishiguchi, Shinji Ueno

Retina Vol. 45 ( 3 ) page： 532 - 540 2025.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Ovid Technologies (Wolters Kluwer Health)

Purpose:

Retinal arterioles are attenuated in eyes with retinitis pigmentosa (RP), but dimensions such as lumen diameter (LD) and wall thickness (WT) have not been thoroughly investigated. This study aimed to determine the dimensions of reduced retinal arterioles in eyes with RP.

Methods:

The study included 66 patients with RP (66 eyes) and 36 control participants (36 eyes) for whom adaptive optics (AO) recordings of the retinal arteries were available. LD and WT were measured on the AO images. The correlations between arteriole dimensions and clinical parameters were determined.

Results:

The mean LD was significantly smaller in patients with RP than in controls, while the mean WT did not differ significantly. LD was significantly and positively correlated with the mean deviation (MD) of the Humphrey 10-2 field analyzer and ellipsoid zone (EZ) width. The WT and wall-to-lumen ratio were significantly and positively correlated with age and systolic blood pressure but not with MD and EZ width.

Conclusion:

Retinal arteriole dimensions were significantly correlated with retinal degeneration and systemic factors.

DOI： 10.1097/IAE.0000000000004333

Scopus

PubMed

Plate Manufacturing Constraint in Topology Optimization Using Anisotropic Filter

Wada, Y; Shimada, T; Nishiguchi, K; Okazawa, S; Tsubokura, M

COMPUTER-AIDED DESIGN Vol. 180 2025.3

Publisher：CAD Computer Aided Design

The manufacturing constraint of topology optimization for finding structures composed primarily of plate cross sections with an automatically decided surface normal is discussed. The anisotropic partial differential equation filter for the sensitivity of the objective function is designed such that the eigenvalue-resolved stress tensor is converted to the anisotropic filter tensor. The user can obtain an optimal shape proposal with different degrees of plate formation by changing the influence radius of the ellipsoidal filter. Plate structure formation and stiffness compliance performance are discussed through three sample problems: a solid bar subjected to torsional loads, an L-shaped member subjected to multiple loads, and a vehicle body frame intended to be a complex frame. The finite element analysis with 3–300 million degrees of freedom is required to form a shell plate structure from a large ingot with a volume fraction constraint of 1%–5%. A voxel topology optimization software that utilizes the building cube method framework available in massively parallel environments is developed, and the parallel performance of the optimization routine, including the plate filtering, is measured.

DOI： 10.1016/j.cad.2024.103823

Web of Science

Scopus

Silicone oil, an intraocular surgical adjuvant, induces retinal ferroptosis

Hideyuki Shimizu, Hiroshi Tanaka, Akira Tazaki, Kazuhisa Yamada, Ayana Suzumura, Junya Ota, Nanako Ushio-Watanabe, Hao Zheng, Keiko Kataoka, Hideaki Hara, Yoshifumi Nishikawa, Tsutomu Yasukawa, Kiyoshi Suzuma, Hiroko Terasaki, Koji M. Nishiguchi, Masashi Kato, Shinya Toyokuni, Hiroki Kaneko

Free Radical Biology and Medicine Vol. 228 page： 33 - 43 2025.2

Classification of fundus autofluorescence images based on macular function in retinitis pigmentosa using convolutional neural networks

Kominami, T; Ueno, S; Ota, J; Inooka, T; Oda, M; Mori, K; Nishiguchi, KM

JAPANESE JOURNAL OF OPHTHALMOLOGY 2025.2

Phenotypic Distinctions Between EYS- and USH2A-Associated Retinitis Pigmentosa in an Asian Population.

Yeo EYH, Kominami T, Tan TE, Babu L, Ong KGS, Tan W, Bylstra YM, Jain K, Tang RWC, Farooqui SZ, Kam SPR, Chan CM, Mathur RS, Jamuar SS, Lim WK, Nishiguchi K, Fenner BJ

Translational vision science & technology Vol. 14 ( 2 ) page： 16 2025.2

Language：English Publisher：Translational vision science & technology

Purpose: This study compares clinical characteristics of retinitis pigmentosa (RP) associated with mutations in the EYS and USH2A genes in a Southeast Asian cohort. Methods: Prospective single-center study of families with EYS- or USH2A-associated RP seen at the Singapore National Eye Centre. Comprehensive ophthalmic evaluations, multimodal imaging, genetic testing, and longitudinal follow-up identified clinically useful differentiating features between the two genotypes. Results: A total of 300 families with RP were enrolled, with EYS- and USH2A-associated RP, accounting for 24.7% of all probands and 50.7% of solved or likely solved cases. USH2A cases were predominantly nonsyndromic RP (75%). EYS-associated RP was more severe in functional and structural outcomes, and patients were more myopic than USH2A (SE -3.31 vs. -0.69; P < 0.0001). EYS RP displayed peripapillary nasal sparing on autofluorescence imaging more frequently than USH2A (57.6% vs. 26.7%; P = 0.006), whereas USH2A cases more often had a parafoveal ring (73.3% vs. 30.3%; P = 0.0002). Multiple logistic regression identified diagnostic features with 83.2% accuracy in distinguishing between EYS and USH2A, validated in a second unrelated clinical cohort. Conclusions: EYS- and USH2A-associated RP have overlapping clinical presentations but can often be distinguished based on a constellation of phenotypic features including disease onset and severity, refractive error, and fundus autofluorescence. These diagnostic features may support a more effective diagnostic strategy for these common forms of RP. Translational Relevance: Distinct clinical features differentiating EYS- and USH2A-associated RP provide valuable diagnostic tools that may inform personalized management and facilitate targeted interventions in clinical practice.

DOI： 10.1167/tvst.14.2.16

Scopus

PubMed

　 PREV - NEXT 　

<Koji Nishiguchi>

Papers - Koji Nishiguchi