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Late gastroenterological complications in children after allogeneic hematopoietic stem cell transplantation: A retrospective cohort study and a case series of children treated with Kampo medicines Open Access

Nozomu Kawashima, Shinsuke Kataoka, Motoharu Hamada, Eri Nishikawa, Rieko Taniguchi, Atsushi Narita, Hideki Muramatsu, Nobuhiro Nishio, Yoshiyuki Takahashi

Traditional and Kampo Medicine 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）

Aim: This study aimed to describe children developing late gastrointestinal (GI) complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT), focusing on Kampo medicine. Methods: At the Nagoya University Hospital Department of Pediatrics, 179 consecutive patients underwent allo-HSCT over five years, of whom 167 achieved engraftment and survived at least 100 days post transplant and therefore were included in the study. Results: Thirteen patients (7.8%) developed late GI symptoms. Among these, three had upper GI symptoms, three had lower GI symptoms, while seven had upper/lower GI symptoms. Total parenteral nutrition was administered in 10 (77%) patients for a median of 81 days (range: 20–303). Four (31%) had histologically proven graft-versus-host-disease (GVHD), two (15%) had adverse drug reactions, and one (8%) had a viral infection. All three patients with lower GI symptoms responded to Kampo formulas' warming interior [TM1]. Two patients with upper GI symptoms had epigastric rigidity and responded to Aurantii Fructus Immaturus-based formulas. One patient developed severe cachexia, which was successfully reversed with Kampo medicines. There were no adverse effects due to Kampo medicines. Conclusions: Late GI complications may be a burden on children after allo-HSCT. Kampo medicines may provide a safe and promising therapy to resolve GI symptoms not otherwise specified.

DOI： 10.1002/tkm2.1392

Open Access

Scopus

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Locatelli, F; Kang, HJ; Bruno, B; Gandemer, V; Rialland, F; Faraci, M; Takahashi, Y; Koh, K; Bittencourt, H; Cleary, G; Rosko, C; Roussou, P; St Pierre, A; Prahallad, A; Díaz-de-Heredia, C

BLOOD 140 巻頁： 1376 - 1378 2022年11月

Impact of the Coronavirus Disease 2019 Pandemic on the Clinical Features of Pediatric Respiratory Syncytial Virus Infection in Japan 査読有り Open Access

Ozeki, S; Kawada, JI; Yamashita, D; Yasufuku, C; Akano, T; Kato, M; Suzuki, K; Tano, C; Matsumoto, K; Mizutani, SH; Mori, A; Nishio, N; Kidokoro, H; Yasui, Y; Takahashi, Y; Sato, Y

OPEN FORUM INFECTIOUS DISEASES 9 巻 ( 11 ) 頁： ofac562 2022年11月

CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY FOLLOWED BY UR-BMT IN TYROSINE KINASE INHIBITOR RESISTANT PEDIATRIC PH1-POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA

Imaya, M; Narita, A; Nishio, N; Wakamatsu, M; Taniguchi, R; Kataoka, S; Muramatsu, H; Ichikawa, D; Maeda, N; Takahashi, Y