Faculty Profiles - YAMAMOTO Eiko

Papers - YAMAMOTO Eiko

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*N-acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of alfa5beta1 integrin Reviewed

Yamamoto E, Ino K, Miyoshi E, Inamori KI, Abe A, Sumigama S, Iwase A, Kajiyama H, Shibata K, Nawa A, Kikkawa F.

Endocrinology Vol. 150 ( 2 ) page： 990-999 2009

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

For successful human placentation, invasion of trophoblast cells into the uterus and its associated vasculature is essential, and the regulation of this process is controlled by many factors at the fetal-maternal interface. N-acetylglucosaminyltransferase V (GnT-V) is a key enzyme that catalyzes beta1, 6-N-acetylglucosamine (beta1-6GlcNAc) branching on asparagine-linked oligosaccharides of cell proteins. GnT-V and its product, beta1-6GlcNAc, are known to regulate cellular transformation and correlate with the metastatic potential of various cancer cells. The aim of the present study was to determine whether extravillous trophoblast (EVT) expressed this molecule and examine the role of GnT-V in the regulation of human trophoblast invasion. Immunohistochemistry showed that GnT-V was strongly expressed within the cytoplasm of EVT in the anchoring villi; this expression was down-regulated in EVTs invading the decidua. Suppression of beta1-6GlcNAc glycosylation by swainsonine enhanced the migratory potential and invasive capability of both primary EVTs and the EVT cell line, HTR-8/SVneo. Down-regulation of GnT-V expression by small interfering RNA in the choriocarcinoma cell line Jar consistently enhanced the migration and invasive capacity of these cells and elevated cellular adhesion to extracellular matrix proteins, such as fibronectin and collagen type I/IV. The extent of beta1-6 branching of alpha5beta1 integrin was significantly reduced in small interfering GnT-V-transfected Jar cells compared with mock transfectants, although the expression of alpha1, alpha5, alpha6, and beta1 integrin on the cell surface was not changed. These results suggest that GnT-V is expressed in human EVT and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin.

*Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion.

Yamamoto E, Ito T, Abe A, Sido F, Ino K, Itakura A, Mizutani S, Dovat S, Nomura S, Kikkawa F.

Molecular Human Reproduction Vol. 11 ( 11 ) page： 825 2005.11

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

The transcriptional factor Ikaros was originally found to function as a key regulator of lymphocyte differentiation. In addition, we have reported that Ikaros regulates the human placental leucine aminopeptidase (P-LAP)/insulin-regulated aminopeptidase (IRAP) gene in choriocarcinoma trophoblastic cells, suggesting that Ikaros might be involved in placental development, while even its presence in human placenta remains undetermined. We therefore sought to clarify the location and roles of Ikaros in human placenta. Immunohistochemical analysis showed modest Ikaris expression in syncytium, and intense expression in extravillous trophoblasts (EVTs) in first trimester placenta. Western blot analysis showed that villous trophoblasts principally expressed Ikaros-2/3, while Ikaros-x (Ikx) was predominantly expressed in cultured EVTs. Furthermore, to investigate the functional role of Ikx in EVTs, the EVT cell line HTR-8/SVneo was infected with a retrovirus vector expressing the hemagglutinin (HA)-tagged dominant negative isoform Ikaros-6 (Ik6), which prevents the DNA-binding activity of Ikx. Antibody against HA showed successful transduction of Ik6 in HTR-8/SVneo cells on immunocytochemistry and Western blotting. Transduction of Ik6 significantly reduced the migratory and invasive abilities of HTR-8/SVneo cells. These results suggest that Ikx is involved in migration and invasion of EVTs in early placentation.

*Expression of N-acetylglucosaminyltransferase V in Endometrial Cancer Correlates with Poor Prognosis Reviewed

Yamamoto E, Ino K, Miyoshi E, Shibata K, Takahashi N, Kajiyama H, Nawa A, Nomura S, Nagasaka T, Kikkawa F

British Journal of Cancer Vol. 97 ( 11 ) page： 1538-1544 2007.12

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

N-acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyses beta1-6 branching of N-acetylglucosamine on asparagine-linked oligosaccharides of cell proteins. The present study aimed to investigate GnT-V expression and its prognostic significance in endometrial cancer. N-acetylglucosaminyltransferase V expression was studied by immunohistochemistry in 74 surgically resected endometrial cancers, and the staining intensity was evaluated. High GnT-V expression in tumour cells was found in 43 (58.1%) of the 74 cases, and was positively correlated with advanced patient age, histological grade, and lymph vascular space involvement. Patients with high GnT-V expression had significantly impaired overall survival and progression-free survival (PFS) (P=0.0041 and P=0.0023, respectively) compared to patients with low expression of GnT-V. On multivariate analysis, GnT-V expression was an independent prognostic factor for PFS (P=0.0364). beta1-6 branching of asparagine-linked oligosaccharides was also detected in GnT-V-positive endometrial cancer cells by leukoagglutinating phytohaemagglutinin (L(4)-PHA) staining, and the molecular size of the major glycoproteins recognised by L(4)-PHA was approximately 60-200 kDa by lectin blot analysis. These results suggested that high GnT-V expression was correlated with an unfavourable clinical outcome, and that GnT-V is involved in the malignant potential of endometrial cancer by increasing the synthesis of beta1-6 branching of asparagine-linked oligosaccharides.

*A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature. Reviewed

Yamamoto E, Ino K, Yamamoto T, Sumigama S, Nawa A, Nomura S, Kikkawa F.

International Journal of Gynecologic Cancer Vol. 17 ( 1 ) page： 254-8 2007.1

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Nongestational pure choriocarcinoma of the ovary is a very rare germ cell tumor. Except in women before menarche, determination of the origin is very difficult without genetic analysis. We present a pure nongestational choriocarcinoma arising in the left ovary of a 19-year-old woman. Following surgery, pathologic findings of the tumor demonstrated pure choriocarcinoma without combination of other germ cell tumor elements. We confirmed its nongestational origin by DNA polymorphism analysis at 15 short tandem repeat loci. Multiple courses of chemotherapy with methotrexate, etoposide, and actinomycin-D were effective for this case. DNA polymorphism analysis is useful to determine genetic origin in pure choriocarcinoma of the ovary.

Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line. Reviewed

Kotani Tomomi, Iwase Akira, Ino Kazuhiko, Sumigama Seiji, Yamamoto Eiko, Hayakawa Hiromi, Nagasaka Toshiro, Itakura Atsuo, Nomura Seiji, Kikkawa Fumitaka.

Endocrinology Vol. 150 ( 9 ) page： 4376-4385 2009.11

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

The reduced migration/invasion of extravillous trophoblasts (EVTs) is a key feature of the genesis of preeclampsia. We and others previously reported that transcriptional factors activator protein-2 (AP-2) alpha and AP-2gamma act as suppressors of tumor invasion. The present study examined the expressions of AP-2alpha and AP-2gamma in preeclamptic placenta vs. control placenta and investigated their effect on the function of EVTs. The expressions of AP-2alpha and AP-2gamma were elevated in the preeclamptic placentas in comparison with the gestational age-matched control placentas. Their expressions also increased in EVTs of the preeclamptic placentas. Thereafter, we transfected AP-2alpha or AP-2gamma into human EVT cell line, HTR-8/SVneo. The overexpression of AP-2alpha or AP-2gamma decreased the migratory and invasive abilities in HTR-8/SVneo cells. This was followed by the reduction of protease activated receptor-1 and matrix metalloproteinases and a significant induction of plasminogen activator inhibitor-1 and the tissue inhibitor of metalloproteinase-1. AP-2alpha and AP-2gamma were weakly expressed in the cultured EVTs and HTR-8/SVneo cells, whereas they were induced by TNF-alpha, which increases in preeclamptic placenta and impairs trophoblast invasion. In the presence of TNF-alpha, the invasion of the HTR-8/SVneo cells was partially restored by a blocking of AP-2 induction using small interfering RNA of AP-2. The present data suggest that AP-2 may suppress trophoblast migration and invasion, thus leading to a shallow placentation in preeclampsia.

*High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary. Reviewed

Takahashi Noriko, Yamamoto Eiko, Ino Kazuhiko, Miyoshi Eiji, Nagasaka Toshiro, Kajiyama Hiroaki, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka

Oncology Report Vol. 22 ( 5 ) page： 1027-1032 2009.11

Language：English Publishing type：Research paper (scientific journal)

N-acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyzes beta1-6 branching of N-acetylglucosamine (GlcNAc) on asparagine-linked oligosaccharides of cell proteins. The present study aimed to investigate GnT-V expression and its prognostic significance in epithelial ovarian cancer. GnT-V expression was studied by immunohistochemistry in 83 surgically resected ovarian cancers, and the staining intensity was evaluated. High GnT-V expression in cancer cells was found in 17 (20.5%) of the 83 cases, and was positively correlated with early FIGO staging. In the histological type, mucinous adenocarcinoma showed significantly strong immunostaining compared to the non-mucinous type (P<0.001). In 36 mucinous tumors, the GnT-V immunostaining score was significantly higher in cancer than in benign and borderline tumors (P<0.001). NOM-1, a human ovarian mucinous adenocarcinoma cell line, expressed strong GnT-V protein and swainsonine treatment suppressed beta1-6GlcNAc branching and reduced migration ability significantly (P<0.001). These results suggested that GnT-V might be involved in the malignant potential of mucinous ovarian cancer.

Tocilizumab inhibits interleukin-6-mediated matrix metalloproteinase-2 and -9 secretions from human amnion cells in preterm premature rupture of membranes. Reviewed

Mano Y, Shibata K, Sumigama S, Hayakawa H, Ino K, Yamamoto E, Kajiyama H, Nawa A, Kikkawa F.

Gynecol Obstet Invest. Vol. 68 ( 3 ) page： 145-153. 2009.7

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND/AIMS: In the present study, we investigated the participation of inflammatory cytokine-induced mediated matrix metalloproteinase (MMP) expressions and inhibition of interleukin (IL)-6-induced MMP secretion in amniotic epithelial cells by tocilizumab. METHODS: To investigate the role of MMP expressions, immunohistochemical staining was performed using membranes obtained from 10 patients with preterm premature rupture of membranes (PPROM) and from 10 patients who underwent a nonlabor cesarean section. We also investigated the regulation of MMP expression by inflammatory cytokines in human amnion cells. RESULTS: Immunohistochemical staining showed a significantly higher expression of MMP-2 and -9 in PPROM. Treatment of cultured WISH and primary amniotic epithelial cells with 10(-8) or 10(-7)M IL-6 or tumor necrosis factor (TNF)-alpha clearly increased the secretion of MMP-2 and -9. Treatment with 10(-8)M TNF-alpha or IL-6 significantly increased the invasion of WISH or primary amniotic epithelial cells, respectively, compared with the control. At a low concentration of 1 microg/ml, tocilizumab (anti-human IL-6 receptor monoclonal antibody) inhibited the IL-6-induced MMP secretion. CONCLUSIONS: This paper is the 1st report of tocilizumab inhibiting IL-6-induced MMP-2 and MMP-9 secretions from human amnion cells in PPROM.

Fertility-sparing operation for recurrence of uterine cervical perivascular epithelioid cell tumor Reviewed

Yamamoto E, Ino K, Sakurai M, Takigawa S, Iwase A, Kikkawa F.

Rare Tumors page： 72-73 2010.2

肝転移巣の破裂による腹腔内出血を契機に診断された絨毛癌の１例 Reviewed

林加奈子,　山本英子,　新美薫,　近藤紳司,　稲葉智子,　井箟一彦, 吉川史隆

東海産科婦人科学会雑誌 Vol. 46 page： 209-212 2010.3

7歳女児に発症した子宮原発横紋筋肉腫の1例 Reviewed

新美薫、山本英子、東真規子、林加奈子、近藤紳司、河合智子、井箟一彦、吉川史隆

日本婦人科腫瘍学会雑誌 Vol. 28 ( 4 ) 2010.10

Factors associated with diabetes mellitus and hypertension among adults in the northern rural area, Afghanistan

Fayaz, SH; Hamajima, N; Frozanfar, MK; Hamrah, MH; Inthaphatha, S; Nishino, K; Yamamoto, E

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 86 ( 4 ) page： 564 - 577 2024.11

Prognostic impact of peritoneal cytology on treating endometrial cancer using data from the Japan Society of Obstetrics and Gynecology cancer registry.

Sakai K, Yamagami W, Takahashi F, Tokunaga H, Yamamoto E, Yokoyama Y, Yoshino K, Kawana K, Nagase S

Journal of gynecologic oncology 2024.10

Sex differences in the prevalence of metabolic syndrome and associated factors in the general population of Mongolia: A nationwide study

Byambadoo, LE; Davaakhuu, N; Surenjav, U; Norov, B; Tserennadmid, E; Inthaphatha, S; Nishino, K; Yamamoto, E

PLOS ONE Vol. 19 ( 10 ) page： e0311320 2024.10

Determinants of the Utilization of Recognized Traditional and Complementary Medicine Service in Malaysia: A Secondary Analysis of a Cross-Sectional Population-Based Survey Reviewed International coauthorship International journal

Ng, SK; Nishino, K; Seman, Z; Inthaphatha, S; Yamamoto, E

COMPLEMENTARY MEDICINE RESEARCH Vol. 31 ( 5 ) page： 427 - 437 2024.10

ESTABLISHMENT OF MTX-RESISTANT CELL LINES OF CHORIOCARCINOMA AND SEARCH FOR THERAPEUTIC AGENTS BY DRUG REPOSITIONING

Nishiko, Y; Niimi, K; Yasui, Y; Yoshida, K; Nishino, K; Yamamoto, E; Kajiyama, H

PLACENTA Vol. 154 page： 234 - 235 2024.9

Factors associated with postpartum depression among Myanmar women in Yangon: A cross-sectional study Reviewed International coauthorship International journal

Wyunn, KM; Wai, ZZT; Swe, KEE; Inthaphatha, S; Nishino, K; Yamamoto, E

HELIYON Vol. 10 ( 13 ) page： e33425 2024.7

Detailed report on the clinicopathological factors of patients with endometrial cancer in Japan: a JSOG gynecologic tumor registry-based study Reviewed International coauthorship International journal

Makabe, T; Yamagami, W; Takahashi, F; Tokunaga, H; Yamamoto, E; Yokoyama, Y; Yoshino, K; Kawana, K; Nagase, S

JOURNAL OF GYNECOLOGIC ONCOLOGY Vol. 35 ( 4 ) page： e54 2024.7

Determinants of postpartum depression among women in Kampong Chhnang Province, Cambodia Reviewed International coauthorship International journal

Guechhorng, I; Inthaphatha, S; Nishino, K; Takahashi, Y; Hamajima, N; Yamamoto, E

ARCHIVES OF PSYCHIATRIC NURSING Vol. 50 page： 60 - 66 2024.6

What inhibits "speaking up" for patient safety among healthcare workers? A cross-sectional study in Malaysia Reviewed International coauthorship International journal

Kim, ARJ; Nishino, K; Bujang, MA; Zulkifli, Z; Inthaphatha, S; Yamamoto, E

HUMAN RESOURCES FOR HEALTH Vol. 22 ( 1 ) page： 35 2024.5

Comparison of the influenza vaccination coverage among high-risk people between the online registration system and walk-in service system in Bangkok, Thailand. Reviewed International coauthorship International journal

Sairuk R, Nishino K, Inthaphatha S, Hamajima N, Yamamoto E

Nagoya journal of medical science Vol. 86 ( 2 ) page： 252 - 261 2024.5

A case of complete remission of intractable gestational choriocarcinoma with subsequent chemotherapy after pembrolizumab (vol 62, pg 745, 2023) Reviewed International journal

Niimi, K; Yamamoto, E; Oda, Y; Nishiko, Y; Shibata, M; Nishino, K; Kajiyama, H

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY Vol. 63 ( 3 ) page： 442 - 442 2024.5

Unmet need for contraception among married women in the Kyrgyz Republic using the datasets from the 2006, 2014 and 2018 Multiple Indicator Cluster Survey: a cross-sectional study Reviewed International coauthorship International journal

Dolonbaeva, Z; Inthaphatha, S; Dzhangaziev, B; Ismailov, M; Nishino, K; Hamajima, N; Yamamoto, E

BMC PUBLIC HEALTH Vol. 24 ( 1 ) page： 977 2024.4

Increased number of live births by migrant mothers shows areal inequality in Japan: A descriptive study (vol 23, 101447, 2023) Reviewed International coauthorship International journal

Nishino, K; Inthaphatha, S; Yamamoto, E

SSM-POPULATION HEALTH Vol. 25 page： 101531 2024.3

Increased number of live births by migrant mothers shows areal inequality in Japan: A descriptive study

Nishino, K; Inthaphatha, S; Yamamoto, E

SSM-POPULATION HEALTH Vol. 25 page： 101532 2024.3

今日の話題在留外国人妊婦による出産

西野公博, 山本英子

産婦人科の実際 Vol. 72 ( 13 ) page： 1501 - 1506 2023.12

Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model

Oda, Y; Niimi, K; Yoshida, K; Tamauchi, S; Yokoi, A; Yasui, Y; Nishiko, Y; Shibata, M; Shimizu, Y; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Yamamoto, E; Kajiyama, H

BMC CANCER Vol. 23 ( 1 ) page： 1103 2023.11

Strong Negative Association between Cesarean Delivery and Early Initiation of Breastfeeding Practices among Vietnamese Mothers-A Secondary Analysis of the Viet Nam Sustainable Development Goal Indicators on Children and Women Survey Reviewed International coauthorship International journal

Nguyen, TTT; Nishino, K; Le, LTH; Inthaphatha, S; Yamamoto, E

NUTRIENTS Vol. 15 ( 21 ) 2023.11

Quality of life in the general population of Mongolia: Normative data on WHOQOL-BREF

Bat-Erdene, E; Hiramoto, T; Tumurbaatar, E; Tumur-Ochir, G; Jamiyandorj, O; Yamamoto, E; Hamajima, N; Oka, T; Jadamba, T; Lkhagvasuren, B

PLOS ONE Vol. 18 ( 9 ) page： e0291427 2023.9

A case of complete remission of intractable gestational choriocarcinoma with subsequent chemotherapy after pembrolizumab

Niimi, K; Yamamoto, E; Oda, Y; Nishiko, Y; Shibata, M; Nishino, K; Kajiyama, H

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY Vol. 62 ( 5 ) page： 745 - 748 2023.9

Increased number of live births by migrant mothers shows areal inequality in Japan: A descriptive study

Nishino, K; Inthaphatha, S; Yamamoto, E

SSM-POPULATION HEALTH Vol. 23 page： 101447 2023.9

Factors associated with pentavalent vaccine coverage among 12-23-month-old children in Afghanistan: A cross-sectional study

Frozanfar, MK; Hamajima, N; Fayaz, SH; Rahimzad, AD; Stanekzai, H; Inthaphatha, S; Nishino, K; Yamamoto, E

PLOS ONE Vol. 18 ( 8 ) page： e0289744 2023.8

The effects of the active education combined with weekly taking iron supplements to increase the nutritional status and anemia of the reproductive Tay ethnic women in Vietnam

Hong, VT; Le, HT; Yamamoto, E; Van Do, H; Nguyen, TTT

ANNALS OF NUTRITION AND METABOLISM Vol. 79 page： 923 - 924 2023.8

特集絨毛性疾患の最新トピックス胞状奇胎のトピックス 3.hCG測定の留意点と低単位hCG持続症例の取り扱い

新美薫, 山本英子

産婦人科の実際 Vol. 72 ( 2 ) page： 121 - 124 2023.2

特集絨毛性疾患の最新トピックス疫学のトピックス 1.絨毛性疾患の発生動向の最新知見

山本英子, 新美薫, 西野公博, 井箟一彦

産婦人科の実際 Vol. 72 ( 2 ) page： 109 - 114 2023.2

Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma

Watanabe, E; Yokoi, A; Yoshida, K; Sugiyama, M; Kitagawa, M; Nishino, K; Yamamoto, E; Niimi, K; Yamamoto, Y; Kajiyama, H

CANCER MEDICINE Vol. 12 ( 4 ) page： 4543 - 4556 2023.2

Validation of the abbreviated version of the World Health Organization Quality of Life in Mongolia: a population-based cross-sectional study among adults in Ulaanbaatar

Bat-Erdene, E; Tumurbaatar, E; Tumur-Ochir, G; Jamiyandorj, O; Jadamba, T; Yamamoto, E; Hamajima, N; Oka, T; Lkhagvasuren, B

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 85 ( 1 ) page： 79 - 92 2023.2

Sickness absence among employees of healthcare organizations in the public sector in Mongolia: A cross-sectional study

Sukhee Erdenetuya, Sovd Tugsdelger, Khaltar Ulzii-Orshikh, Hamajima Nobuyuki, Sereenen Enkhbold, Davaakhuu Narantuya, Yamamoto Eiko

Journal of Occupational Health Vol. 65 ( 1 ) page： e12390 2023.1

Language：English Publisher：Japan Society for Occupational Health

Objectives: This study aimed to understand the rate of sickness absence (SA) among employees of public healthcare organizations in Mongolia, to identify factors associated with long-term SA, and to estimate costs due to SA.Methods: This cross-sectional study included employees of public healthcare organizations who had certified SA from 2016 to 2018. Sociodemographic and occupational characteristics of absentees and the data on absences were collected. A logistic regression analysis was performed to identify factors associated with long-term SA (≥15 days) among employees who had SA. Absence parameters and the average costs due to SA were calculated and the total cost due to SA at all public healthcare organizations was estimated.Results: From 2016 to 2018, there were 13 653 absentees and 21 043 SA, and the absence rate was 0.9%. The average absence length per absence and absentee were 9.63 days and 14.85 days, respectively. Factors associated with long-term SA were age ≥40 years, 10-19 years in employment, working at the second and tertiary levels, and night shift. The average cost per absentee was 295.5 USD, and the estimated total cost for all health organizations was 1 796 993 USD per year.Conclusions: The absence rate was 0.9% and older age, longer work experience, higher organizational level, and night shift were associated with taking a long-term SA. To reduce the costs of absenteeism and promote the health of employees in healthcare organizations, policymakers should review the policies related to SA and develop national guidelines on SA for employers, healthcare managers, and employees.

DOI： 10.1002/1348-9585.12390

Web of Science

PubMed

CiNii Research

Menstrual health and factors associated with school absence among secondary school girls in Luang Prabang Province, Lao People's Democratic Republic: A cross-sectional study

Inthaphatha, S; Louangpradith, V; Xiong, LI; Xiong, V; Ly, L; Xaitengcha, V; Phengsavanh, A; Hamajima, N; Yamamoto, E

PLOS ONE Vol. 16 ( 12 ) page： e0261268 2021.12

特集図解　分子メカニズムから理解する婦人科がんの薬物療法【各論】 Ⅲ　子宮体部悪性腫瘍 4.絨毛性疾患

西野公博, 新美薫, 山本英子

産婦人科の実際 Vol. 70 ( 12 ) page： 1522 - 1528 2021.11

特集　ヒト胎盤機能と病態絨毛性疾患のup-date

新美薫, 山本英子

HORMONE FRONTIER IN GYNECOLOGY Vol. 28 ( 3 ) page： 59 - 65 2021.9

特集婦人科がん機能温存治療のすべて絨毛性疾患　妊孕性温存 Invited

山本英子, 新美薫, 西野公博

産科と婦人科 Vol. 88 ( 7 ) page： 849 - 853 2021.7

Rate of achievement of therapeutic outcomes and factors associated with control of non-communicable diseases in rural east Malaysia: implications for policy and practice

Keng, ZY; Saw, YM; Thung, SC; Chong, WW; Albert, A; Kariya, T; Yamamoto, E; Hamajima, N

SCIENTIFIC REPORTS Vol. 11 ( 1 ) page： 3812 2021.2

Trends and risk factors for infant mortality in the Lao People's Democratic Republic. Reviewed International coauthorship International journal

Viengsakhone Louangpradith, Eiko Yamamoto, Souphalak Inthaphatha, Bounfeng Phoummalaysith, Tetsuyoshi Kariya, Yu Mon Saw, Nobuyuki Hamajima

Scientific reports Vol. 10 ( 1 ) page： 21723 - 21723 2020.12

Language：English Publishing type：Research paper (scientific journal)

A high infant mortality rate (IMR) indicates a failure to meet people's healthcare needs. The IMR in Lao People's Democratic Republic has been decreasing but still remains high. This study aimed to identify the factors involved in the high IMR by analyzing data from 53,727 live births and 2189 women from the 2017 Lao Social Indicator Survey. The estimated IMR decreased from 191 per 1000 live births in 1978-1987 to 39 in 2017. The difference between the IMR and the neonatal mortality rate had declined since 1978 but did not change after 2009. Factors associated with the high IMR in all three models (forced-entry, forward-selection, and backward-selection) of multivariate logistic regression analyses were auxiliary nurses as birth attendants compared to doctors, male infants, and small birth size compared to average in all 2189 women; and 1-3 antenatal care visits compared to four visits, auxiliary nurses as birth attendants compared to doctors, male infants, postnatal baby checks, and being pregnant at the interview in 1950 women whose infants' birth size was average or large. Maternal and child healthcare and family planning should be strengthened including upgrading auxiliary nurses to mid-level nurses and improving antenatal care quality.

DOI： 10.1038/s41598-020-78819-9

Web of Science

PubMed

Factors associated with postpartum depression among women in Vientiane Capital, Lao People's Democratic Republic: A cross-sectional study. Reviewed International coauthorship International journal

Souphalak Inthaphatha, Eiko Yamamoto, Viengsakhone Louangpradith, Yuki Takahashi, Alongkone Phengsavanh, Tetsuyoshi Kariya, Yu Mon Saw, Nobuyuki Hamajima

PloS one Vol. 15 ( 12 ) page： e0243463 2020.12

Language：English Publishing type：Research paper (scientific journal)

Postpartum depression is a worldwide public health concern. The prevalence of postpartum depression is reported to be greater in developing countries than in developed countries. However, to the best of our knowledge, no papers on postpartum depression in the Lao People's Democratic Republic have been published. In order to strengthen maternal and child health, the current situation of postpartum depression should be understood. This study aims to determine the prevalence of postpartum depression and identify factors associated with postpartum depression in Vientiane Capital, Lao People's Democratic Republic. Study participants were 428 women 6-8 weeks postpartum who visited four central hospitals in Vientiane Capital for postnatal care from July to August 2019. Structured questionnaires were used to collect socio-demographic, obstetrical and infant, and psychiatric data about the women and their partners. The Edinburgh Postnatal Depression Scale (EPDS) was used to identify suspected cases of postpartum depression with the cut-off score of 9/10. Multivariable logistic regression was used to examine independent factors that were associated with suspected postpartum depression (EPDS ≥10). The mean age of the 428 women was 28.1 years, and the prevalence of suspected postpartum depression was 31.8%. Multivariable logistic regression using variables that were statistically significant on bivariate analyses indicated that three variables were associated with suspected postpartum depression: unintended pregnancy (AOR = 1.66, 95% CI 1.00-2.73, P = 0.049), low birth satisfaction (AOR = 1.85, 95% CI 1.00-3.43, P = 0.049), and depression during pregnancy (AOR = 3.99, 95% CI 2.35-6.77, P <0.001). In this study, unintended pregnancy, low birth satisfaction, and depression during pregnancy were independent risk factors for postpartum depression. These results suggest that the mental health of pregnant women should be monitored, and that health care services, especially family planning and supportive birth care, should be strengthened to prevent postpartum depression.

DOI： 10.1371/journal.pone.0243463

Web of Science

PubMed

特集異所性妊娠の最新診療異所性絨毛性疾患 Invited

新美薫, 山本英子, 吉川史隆

産科と婦人科 Vol. 87 ( 7 ) page： 829 - 834 2020.7

The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study Reviewed

Yamamoto, E; Minh, TD; Sekiya, Y; Tamakoshi, K; Nguyen, XP; Nishino, K; Kotani, KT; Kajiyama, H; Shibata, K; Le, QT; Kikkawa, F

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 2 ) page： 183 - 191 2020.5

増刊号産婦人科処方のすべて2020-症例に応じた実践マニュアル婦人科編 Ⅳ.腫瘍絨毛性疾患

新美薫, 山本英子, 梶山広明

臨床婦人科産科 Vol. 74 ( 4 ) page： 215 - 218 2020.4

特集やさしくわかる　産科婦人科検査マスターブック (第2章)婦人科腫瘍分野　絨毛性疾患のhCG

山本英子, 新美薫, 西野公博

産科と婦人科 Vol. 87 ( 13 ) page： 168 - 171 2020.3

Outcome of cesarean scar pregnancy treated with local methotrexate injection Reviewed International coauthorship

Tam, LM; Kotani, T; Linh, TM; Thu, PTM; Khanh, TV; Anh, NTK; Nguyen, NTT; Moriyama, Y; Yamamoto, E; Huy, NVQ; Vinh, TQ; Thanh, CN; Kikkawa, F

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 1 ) page： 15 - 23 2020.2

The efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide and actinomycin D in patients with choriocarcinoma and high-risk gestational trophoblastic neoplasia Reviewed

Sato, S; Yamamoto, E; Niimi, K; Ino, K; Nishino, K; Suzuki, S; Kotani, T; Kajiyama, H; Kikkawa, F

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 25 ( 1 ) page： 203 - 209 2020.1

IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery Invited Reviewed International coauthorship

Albrecht Christiane, Chamley Larry, Charnock-Jones D. Stephen, Collins Sally, Fujiwara Hiroshi, Golos Thaddeus, Grayo Solene, Hannan Natalie, Harris Lynda, Ichizuka Kiyotake, Illsley Nicholas P., Iwashita Mitsutoshi, Kallol Sampada, Al-Khan Abdulla, Lash Gendie, Nagamatsu Takeshi, Nakashima Akitoshi, Niimi Kaoru, Nomoto Masataka, Redman Christopher, Saito Shigeru, Tanimura Kenji, Tomi Masatoshi, Usui Hirokazu, Vatish Manu, Wolfe Bryce, Yamamoto Eiko, O'Tierney-Ginn Perrie

PLACENTA Vol. 84 page： 9 - 13 2019.9

Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma Reviewed

Kajiyama Hiroaki, Suzuki Shiro, Utsumi Fumi, Yoshikawa Nobuhisa, Nishino Kimihiro, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Eiko, Kawai Michiyasu, Shibata Kiyosumi, Nagasaka Tetsuro, Kikkawa Fumitaka

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 24 ( 8 ) page： 950 - 956 2019.8

Multiple ruptured cerebral aneurysms at the National Hospital of the Kyrgyz Republic between 2008 and 2014: a departmental summary Reviewed International coauthorship

Yrysov Keneshbek, Tursunov Doniyorjon, Reyer Joshua A., Yamamoto Eiko, Yrysova Mirgul, Hamajima Nobuyuiki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 3 ) page： 511 - 518 2019.8

Factors associated with HIV testing among the general male population in Cambodia: A secondary data analysis of the Demographic Health Survey in 2005, 2010, and 2014 Reviewed International coauthorship

Narin Piseth, Yamamoto Eiko, Saw Yu Mon, Net Ny, Inthaphatha Souphalak, Kariya Tetsuyoshi, Hamajima Nobuyuki

PLOS ONE Vol. 14 ( 7 ) page： e0219820 2019.7

Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia Reviewed

Iriyama Takayuki, Wang Guan, MidoriYoshikawa, Mimura Nobuko, Matsui Haruka, Sayama Seisuke, Kumasawa Keiichi, Nagamatsu Takeshi, Koga Kaori, Kotani Tomomi, Niimi Kaoru, Yamamoto Eiko, Kellems Rodney E., Xia Yang, Osuga Yutaka, Fujii Tomoyuki

SCIENTIFIC REPORTS Vol. 9 ( 1 ) page： 10107 2019.7

Cognitive function measured with the Revised Hasegawa's Dementia Scale among elderly individuals in Lao PDR Reviewed International coauthorship

Kounnavong Sengchanh, Ratsavong Kethmany, Soundavong Khouanchay, Xayavong Syda, Kariya Tetsuyoshi, Saw Yu Mon, Yamamoto Eiko, Horibe Kentaro, Toba Kenji, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 2 ) page： 281 - 290 2019.5

Outbreak detection of influenza-like illness in Prey Veng Province, Cambodia: a community-based surveillance Reviewed International coauthorship

Long-Hay Puthik, Yamamoto Eiko, Bun Sreng, Savuth Thai, Buntha So, Sokdaro Soy, Kariya Tetsuyoshi, Saw Yu Mon, Sengdoeurn Yi, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 2 ) page： 269 - 280 2019.5

Consumption of foods containing prohibited artificial colors among middle-school children in Nay Pyi Taw union territory, Myanmar Reviewed International coauthorship

Oo Nwe, Saw Yu Mon, Aye Hnin Nwe Ni, Aung Zaw Zaw, Kyaw Hnin Nandar, Tun Ae Mon, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

BMC PUBLIC HEALTH Vol. 19 ( 1 ) page： 344 2019.3

Survival rate and mortality risk factors among TB-HIV co-infected patients at an HIV-specialist hospital in Myanmar: A 12-year retrospective follow-up study Reviewed International coauthorship

Aung Zaw Zaw, Saw Yu Mon, Saw Thu Nandar, Oo Nwe, Aye Hnin Nwe Ni, Aung Sithu, Oo Htun Nyunt, Cho Su Myat, Khaing Moe, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES Vol. 80 page： 10 - 15 2019.3

Antibiotic prescription for under-fives with common cold or upper respiratory tract infection in Savannakhet Province, Lao PDR Reviewed International coauthorship

Keohavong Bounxou, Vonglokham Manithong, Phoummalaysith Bounfeng, Louangpradith Viengsakhone, Inthaphatha Souphalak, Kariya Tetsuyoshi, Saw Yu Mon, Yamamoto Eiko, Hamajima Nobuyuki

TROPICAL MEDICINE AND HEALTH Vol. 47 page： 16 2019.2

Free and universal access to primary healthcare in Mongolia: the service availability and readiness assessment Reviewed International coauthorship

Jigjidsuren Altantuya, Byambaa Tumurbat, Altangerel Enkhjargal, Batbaatar Suvd, Saw Yu Mon, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

BMC HEALTH SERVICES RESEARCH Vol. 19 ( 1 ) page： 129 2019.2

Epidemiological characteristics and trends of a Nationwide measles outbreak in Mongolia, 2015-2016 Reviewed International coauthorship

Orsoo Oyunchimeg, Saw Yu Mon, Sereenen Enkhbold, Yadamsuren Buyanjargal, Byambaa Ariunsanaa, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

BMC PUBLIC HEALTH Vol. 19 ( 1 ) page： 201 2019.2

Factors associated with antenatal care visits in Afghanistan: secondary analysis of Afghanistan Demographic and Health Survey 2015 Reviewed International coauthorship

Azimi Mohammad Walid, Yamamoto Eiko, Saw Yu Mon, Kariya Tetsuyoshi, Arab Ahmad Shekib, Sadaat Said Iftekhar, Farzad Fraidoon, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 1 ) page： 121 - 131 2019.2

Patient satisfaction on the utilization of traditional and complementary medicine services at public hospitals in Malaysia Reviewed International coauthorship

Kaur Jaspal, Hamajima Nobuyuki, Yamamoto Eiko, Saw Yu Mon, Kariya Tetsuyoshi, Soon Goh Cheng, Amin Ariyani, Halim Adilla Nur, Aziz Farhana Abdul, Sharon Suraya Hani

COMPLEMENTARY THERAPIES IN MEDICINE Vol. 42 page： 422 - 428 2019.2

Knowledge, attitude, and usage pattern of tobacco among high school students in Nay Pyi Taw, Myanmar Reviewed International coauthorship

Myint Myat Noe Htin Aung, Yamamoto Eiko, Ko Min Htet, Khaing Moe, Reyer Joshua A., Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 1 ) page： 65 - 79 2019.2

Healthcare waste management at primary health centres in Mon State, Myanmar: the comparisons between hospital and non-hospital type primary health centres Reviewed International coauthorship

Win Ei Mon, Saw Yu Mon, Oo Kyi Lwin, Than Thet Mon, Cho Su Myat, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 1 ) page： 81 - 91 2019.2

The role of E2F8 in the human placenta Reviewed International coauthorship

Mizuno Masako, Miki Rika, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Niimi Kaoru, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Senga Takeshi, Iwase Akira, Kikkawa Fumitaka, Kotani Tomomi

MOLECULAR MEDICINE REPORTS Vol. 19 ( 1 ) page： 293 - 301 2019.1

Assessing the operational costs of routine immunization activities at the sub-center level in Myanmar: What matters for increasing national immunization coverage ?

Aye Hnin Nwe Ni, Saw Yu Mon, Thar Aye Mya Chan, Oo Nwe, Aung Zaw Zaw, Tin Htun, Than Thet Mon, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

VACCINE Vol. 36 ( 49 ) page： 7542 - 7548 2018.11

Myanmar language version of the Revised Hasegawa's Dementia Scale

Saw Yu Mon, Than Thet Mon, Win Ei Mon, Cho Su Myat, Khaing Moe, Latt Nyi Nyi, Aung Zaw Zaw, Oo Nwe, Aye Hnin Nwe Ni, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 4 ) page： 435 - 450 2018.11

Associations of treatment completion against drug addiction with motivational interviewing and related factors in Afghanistan

Rasekh Bakhtar, Saw Yu Mon, Azimi Sayed, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 3 ) page： 329 - 340 2018.8

Tobacco Control Law awareness, enforcement, and compliance among high school students in Myanmar

Latt Nyi Nyi, Saw Yu Mon, Cho Su Myat, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 3 ) page： 379 - 389 2018.8

Factors associated with routine immunization coverage of children under one year old in Lao People's Democratic Republic

Phoummalaysith Bounfeng, Yamamoto Eiko, Xeuatvongsa Anonh, Louangpradith Viengsakhone, Keohavong Bounxou, Saw Yu Mon, Hamajima Nobuyuki

VACCINE Vol. 36 ( 19 ) page： 2666 - 2672 2018.5

Waiting time in the outpatient clinic at a national hospital in Vietnam

Suong Thi Thao Nguyen, Yamamoto Eiko, Mai Thi Ngoc Nguyen, Huy Bao Le, Kariya Tetsuyoshi, Yu Mon Saw, Cong Duc Nguyen, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 2 ) page： 227 - 239 2018.5

Dengue fever during pregnancy.

Tien Dat T, Kotani T, Yamamoto E, Shibata K, Moriyama Y, Tsuda H, Yamashita M, Kajiyama H, Duc Thien Minh D, Quang Thanh L, Kikkawa F

Nagoya journal of medical science Vol. 80 ( 2 ) page： 241 - 247 2018.5

Secondary cytoreductive surgery potentially improves the oncological outcomes of patients with recurrent uterine sarcomas

Nakamura Kenichi, Kajiyama Hiroaki, Utsumi Fumi, Suzuki Shiro, Niimi Kaoru, Sekiya Ryuichiro, Sakata Jun, Yamamoto Eiko, Shibata Kiyosumi, Kikkawa Fumitaka

MOLECULAR AND CLINICAL ONCOLOGY Vol. 8 ( 3 ) page： 499 - 503 2018.3

Establishment of an antibody specific for cancer-associated haptoglobin: a possible implication of clinical investigation.

Nishino K, Koda S, Kataoka N, Takamatsu S, Nakano M, Ikeda S, Kamamatsu Y, Morishita K, Moriwaki K, Eguchi H, Yamamoto E, Kikkawa F, Tomita Y, Kamada Y, Miyoshi E

Oncotarget Vol. 9 ( 16 ) page： 12732 - 12744 2018.2

Estimated costs for treatment and prophylaxis of newborn vitamin K deficiency bleeding in Tashkent, Uzbekistan

Tursunov Doniyorjon, Yoshida Yoshitoku, Yrysov Keneshbek, Sabirov Dilmurad, Alimova Khilola, Yamamoto Eiko, Reyer Joshua A., Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 1 ) page： 11 - 20 2018.2

The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis

Moroi Hiroaki, Kotani Tomomi, Miki Rika, Tsuda Hiroyuki, Mizuno Masako, Ito Yumiko, Ushida Takafumi, Mai Kenji, Nakano Tomoko, Li Hua, Sumigama Seiji, Yamamoto Eiko, Was Akira, Kikkawa Fumitaka

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION Vol. 62 ( 1 ) page： 63 - 67 2018.1

Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells

Sakata Jun, Utsumi Fumi, Suzuki Shiro, Niimi Kaoru, Yamamoto Eiko, Shibata Kiyosumi, Senga Takeshi, Kikkawa Fumitaka, Kajiyama Hiroaki

ONCOTARGET Vol. 8 ( 59 ) page： 99482 - 99494 2017.11

Medical facility statistics in Japan

Hamajima Nobuyuki, Sugimoto Takuya, Hasebe Ryo, Cho Su Myat, Khaing Moe, Kariya Tetsuyoshi, Saw Yu Mon, Yamamoto Eiko

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 79 ( 4 ) page： 515 - 525 2017.11

Unit cost of healthcare services at 200-bed public hospitals in Myanmar: what plays an important role of hospital budgeting?

Than Thet Mon, Saw Yu Mon, Khaing Moe, Win Ei Mon, Cho Su Myat, Kariya Tetsuyoshi, Yamamoto Eiko, Hamajima Nobuyuki

BMC HEALTH SERVICES RESEARCH Vol. 17 ( 1 ) page： 669 2017.9

Establishment and characterization of cell lines derived from complete hydatidiform mole

Yamamoto Eiko, Niimi Kaoru, Kiyono Tohru, Yamamoto Toshimichi, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol. 40 ( 3 ) page： 614 - 622 2017.9

Erratum: High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review.

Yamamoto E, Niimi K, Fujikake K, Nishida T, Murata M, Mitsuma A, Ando Y, Kikkawa F

Molecular and clinical oncology Vol. 7 ( 3 ) page： 510 2017.9

Assessment of knowledge about snakebite management amongst healthcare providers in the provincial and two district hospitals in Savannakhet Province, Lao PDR

Inthanomchanh Vongphoumy, Reyer Joshua A., Blessmen Joerg, Phrasisombath Ketkesone, Yamamoto Eiko, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 79 ( 3 ) page： 299 - 311 2017.8

Spontaneous regression of gestational trophoblastic neoplasia.

Niimi K, Yamamoto E, Nishino K, Fujiwara S, Ino K, Kikkawa F

Gynecologic oncology reports Vol. 21 page： 98 - 100 2017.8

N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma

Nishino Kimihiro, Yamamoto Eiko, Niimi Kaoru, Sekiya Yoko, Yamashit Yoriko, Kikkawa Fumitaka

ONCOLOGY REPORTS Vol. 38 ( 1 ) page： 440 - 448 2017.7

Knowledge of free delivery policy among women who delivered at health facilities in Oudomxay Province, Lao PDR

Chankham Tengbriacheu, Yamamoto Eiko, Reyer Joshua A., Arafat Rahman, Khonemany Innoukham, Panome Sayamoungkhoun, Hongkham Dalavong, Bounfeng Phommalaysith, Anonh Xeuthvongsa, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 79 ( 2 ) page： 135 - 145 2017.5

Underlying Cause of Death Recorded during 2013 to 2015 at a Tertiary General Hospital in Vientiane Capital, Lao PDR

Phoummalaysith Bounfeng, Louangpradith Viengsakhone, Manivon Tavanh, Keohavong Bounxou, Yamamoto Eiko, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 79 ( 2 ) page： 199 - 209 2017.5

Socio-economic and demographic determinants of full immunization among children of 12-23 months in Afghanistan

Farzad Fraidoon, Reyer Joshua A., Yamamoto Eiko, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 79 ( 2 ) page： 179 - 188 2017.5

Lao language version of the Revised Hasegawa's Dementia Scale

Kounnavong Sengchanh, Soundavong Khouanchay, Xayavong Syda, Vongpraserth Nialoun, Bounsavath Phongsavang, Houatthongkham Souphatsone, Phoummalaysith Bounfeng, Saw Yu Mon, Yamamoto Eiko, Toba Kenji, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 79 ( 2 ) page： 241 - 249 2017.5

c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling

Sekiya Yoko, Yamamoto Eiko, Niimi Kaoru, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka

ONCOLOGY Vol. 92 ( 5 ) page： 299 - 310 2017

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model

Ushida Takafumi, Kotani Tomomi, Tsuda Hiroyuki, Imai Kenji, Nakano Tomoko, Hirako Shima, Ito Yumiko, Li Hua, Mano Yukio, Wang Jingwen, Miki Rika, Yamamoto Eiko, Iwase Akira, Bando Yasuko K., Hirayama Masaaki, Ohno Kinji, Toyokuni Shinya, Kikkawa Fumitaka

FREE RADICAL BIOLOGY AND MEDICINE Vol. 101 page： 524 - 533 2016.12

High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review.

Yamamoto E, Niimi K, Fujikake K, Nishida T, Murata M, Mitsuma A, Ando Y, Kikkawa F

Molecular and clinical oncology Vol. 5 ( 5 ) page： 660 - 664 2016.11

A PROSPECTIVE STUDY FOR THE EXPECTANT MANAGEMENT OF PLACENTAL POLYP

Takikawa Sachiko, Iwase Akira, Sato Shizuka, Nakamura Kenichi, Nagai Takashi, Kasahara Yukiyo, Osuka Satoko, Niimi Kaoru, Imai Kenji, Nakano Tomoko, Tsuda Hiroyuki, Yamamoto Eiko, Kotani Tomomi, Goto Maki, Kikkawa Fumitaka

PLACENTA Vol. 46 page： 106 - 106 2016.10

Gestational Trophoblastic Neoplasia and Pregnancy Outcome After Routine Second Curettage for Hydatidiform Mole A Retrospective Observational Study.

Kan M, Yamamoto E, Niimi K, Tamakoshi K, Sekiya Y, Nishino K, Ino K, Kikkawa F

The Journal of reproductive medicine Vol. 61 ( 7-8 ) page： 373 - 379 2016.8

Assessment of hand hygiene compliance after hand hygiene education among health care workers in Cambodia

Sansam Sim, Yamamoto Eiko, Srun Sok, Sinath Yin, Moniborin Mey, Sim Kheang Bun, Reyer Joshua A., Yoshida Yoshitoku, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 78 ( 2 ) page： 151 - 162 2016.5

Healthcare in Myanmar

Latt Nyi Nyi, Cho Su Myat, Htun Nang Mie Mie, Saw Yu Mon, Myint Myat Noe Htin Aung, Aoki Fumiko, Reyer Joshua A., Yamamoto Eiko, Yoshida Yoshitoku, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 78 ( 2 ) page： 123 - 134 2016.5

Assessment of hand hygiene compliance after hand hygiene education among health care workers in Cambodia.

Sansam S, Yamamoto E, Srun S, Sinath Y, Moniborin M, Bun Sim K, Reyer JA, Yoshida Y, Hamajima N

Nagoya journal of medical science Vol. 78 ( 2 ) page： 151 - 62 2016.5

Healthcare in Myanmar.

Latt NN, Myat Cho S, Htun NM, Yu Mon Saw, Myint MN, Aoki F, Reyer JA, Yamamoto E, Yoshida Y, Hamajima N

Nagoya journal of medical science Vol. 78 ( 2 ) page： 123 - 34 2016.5

Acute malnutrition among under-five children in Faryab, Afghanistan: prevalence and causes

Frozanfar Muhammad Kamel, Yoshida Yoshitoku, Yamamoto Eiko, Reyer Joshua A., Dalil Suraya, Rahimzad Abdullah Darman, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 78 ( 1 ) page： 41 - 53 2016.2

Acute malnutrition among under-five children in Faryab, Afghanistan: prevalence and causes.

Frozanfar MK, Yoshida Y, Yamamoto E, Reyer JA, Dalil S, Rahimzad AD, Hamajima N

Nagoya journal of medical science Vol. 78 ( 1 ) page： 41 - 53 2016.2

Pediatric cardiothoracic program in Malaysia: a study based on the outcome of the program.

Piros Kulandasamy Pillai C, Yoshida Y, Justin Lawrence P, Yamamoto E, Reyer JA, Hamajima1 N

Nagoya journal of medical science Vol. 78 ( 1 ) page： 9 - 17 2016.2

Trends in attrition among medical teaching staff at universities in Myanmar 2009-2013.

Nang Mie Mie Htun, Reyer JA, Yamamoto E, Yoshida Y, Hamajima N

Nagoya journal of medical science Vol. 78 ( 1 ) page： 27 - 40 2016.2

Trends in amenable mortality rate in the Mongolian population, 2007-2014.

Surenjav E, Sovd T, Yoshida Y, Yamamoto E, Reyer JA, Hamajima N

Nagoya journal of medical science Vol. 78 ( 1 ) page： 55 - 68 2016.2

Pediatric cardiothoracic program in Malaysia: a study based on the outcome of the program

Pillai Cornelius Piros Kulandasamy, Yoshida Yoshitoku, Lawrence Patrick Justin, Yamamoto Eiko, Reyer Joshua A., Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 78 ( 1 ) page： 9 - 17 2016.2

Trends in amenable mortality rate in the Mongolian population, 2007-2014

Surenjav Enkhjin, Sovd Tugsdelger, Yoshida Yoshitoku, Yamamoto Eiko, Reyer Joshua A., Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 78 ( 1 ) page： 55 - 68 2016.2

Trends in attrition among medical teaching staff at universities in Myanmar 2009-2013

Htun Nang Mie Mie, Reyer Joshua A., Yamamoto Eiko, Yoshida Yoshitoku, Hamajima Nobuyuki

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 78 ( 1 ) page： 27 - 40 2016.2

Gestational Trophoblastic Neoplasia and Pregnancy Outcome After Routine Second Curettage for Hydatidiform Mole: A Retrospective Observational Study

Kan Momo, Yamamoto Eiko, Niimi Kaoru, Tamakoshi Koji, Sekiya Yoko, Nishino Kimihiro, Ino Kazuhiko, Kikkawa Fumitaka

JOURNAL OF REPRODUCTIVE MEDICINE Vol. 61 ( 7-8 ) page： 373 - 379 2016

THE MANAGEMENT OF PLACENTAL ABRUPTION

Kotani Tomomi, Moroi Hiroaki, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Kikkawa Fumitaka

PLACENTA Vol. 36 ( 9 ) page： A49 - A49 2015.9

Opioid needs of terminally ill patients with gynecologic malignancies

Utsumi Fumi, Kajiyama Hiroaki, Sakata Jun, Higashi Makiko, Niimi Kaoru, Sekiya Ryuichiro, Mitsui Hiroko, Suzuki Shiro, Umezu Tomokazu, Mizuno Mika, Yamamoto Eiko, Shibata Kiyosumi, Kikkawa Fumitaka

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 20 ( 2 ) page： 405 - 410 2015.4

A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age. Reviewed

Kajiyama H, Mizuno M, Shibata K, Umezu T, Suzuki S, Yamamoto E, Mitsui H, Sekiya R, Niimi K, Kawai M, Nagasaka T, Kikkawa F.

Int J Clin Oncol. Vol. 19 ( 5 ) page： 921 - 927 2014.10

Oncologic outcome after recurrence in patients with stage I epithelial ovarian cancer: are clear-cell and mucinous histological types a different entities?

Kajiyama Hiroaki, Mizuno Mika, Shibata Kiyosumi, Umezu Tomokazu, Suzuki Shiro, Yamamoto Eiko, Mitsui Hiroko, Sekiya Ryuichiro, Niimi Kaoru, Kawai Michiyasu, Nagasaka Tetsuro, Kikkawa Fumitaka

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY Vol. 181 page： 305 - 310 2014.10

WHAT A ROLE ATYPICAL E2F PLAYS IN HUMAN PLACENTAL DEVELOPMENT?

Sawada Masako, Kotani Tomomi, Miki Rika, Li Hua, Moroi Hiroaki, Imai Kenji, Nakano Tomoko, Niimi Kaoru, Yamamoto Eiko, Mano Yukio, Tsuda Hiroyuki, Sumigama Seiji, Kikkawa Fumitaka

PLACENTA Vol. 35 ( 10 ) page： A12 - A12 2014.10

CORE 2 beta 1, 6-N ACETYLGLCOSAMINYL TRANSFERASE MAY REGULATE CELL INVASION IN CHORIOCARCINOMA

Niimi Kaoru, Yamamoto Eiko, Miwa Yoko, Nishino Kimihiro, Mano Yukio, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

PLACENTA Vol. 35 ( 9 ) page： A49 - A50 2014.9

POSSIBLE INVOLVEMENT OF ENDOGLIN IN THE PATHOGENESIS OF PREECLAMPSIA

Mano Yukio, Ushida Takafumi, Nakano Tomoko, Niimi Kaoru, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Kotani Tomomi, Kikkawa Fumitaka

PLACENTA Vol. 35 ( 9 ) page： A82 - A83 2014.9

TRANSCRIPTIONAL REGULATION OF HUMAN N-ACETYLGLUCOSAMINYLTRANSFERASE IVA GENE IN TROPHOBLASIS

Miwa Yoko, Yamamoto Eiko, Shinjo Kanako, Niimi Kaoru, Nishino Kimihiro, Mano Yukio, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

PLACENTA Vol. 35 ( 9 ) page： A50 - A50 2014.9

Identification of causative pregnancy of gestational trophoblastic neoplasia diagnosed during pregnancy by short tandem repeat analysis. Reviewed

Yamamoto E, Niimi K, Shinjo K, Yamamoto T, Fukunaga M, Kikkawa F

Gynecologic oncology case reports Vol. 9 ( 18 ) page： 3 - 6 2014.8

Expression of chromobox homolog 7 ( CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation

Shinjo Kanako, Yamashita Yoriko, Yamamoto Eiko, Akatsuka Shinya, Uno Nozomi, Kamiya Akihiro, Niimi Kaoru, Sakaguchi Yuka, Nagasaka Tetsuro, Takahashi Takashi, Shibata Kiyosumi, Kajiyama Hiroaki, Kikkawa Fumitaka, Toyokuni Shinya

INTERNATIONAL JOURNAL OF CANCER Vol. 135 ( 2 ) page： 308 - 318 2014.7

Possible association between stem-like hallmark and radioresistance in human cervical carcinoma cells

Kumazawa Shoko, Kajiyama Hiroaki, Umezu Tomokazu, Mizuno Mika, Suzuki Shiro, Yamamoto Eiko, Mitsui Hiroko, Sekiya Ryuichiro, Shibata Kiyosumi, Kikkawa Fumitaka

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Vol. 40 ( 5 ) page： 1389 - 1398 2014.5

Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells

Niimi Kaoru, Murakumo Yoshiki, Watanabe Naoki, Kato Takuya, Mii Shinji, Enomoto Atsushi, Asai Masato, Asai Naoya, Yamamoto Eiko, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka, Takahashi Masahide

CANCER SCIENCE Vol. 105 ( 5 ) page： 545 - 552 2014.5

Recurrence-predicting prognostic factors for patients with early-stage epithelial ovarian cancer undergoing fertility-sparing surgery: a multi-institutional study

Kajiyama Hiroaki, Mizuno Mika, Shibata Kiyosumi, Yamamoto Eiko, Kawai Michiyasu, Nagasaka Tetsuro, Kikkawa Fumitaka

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY Vol. 175 page： 97 - 102 2014.4

Is There Any Association between Where Patients Spend the End of Life and Survival after Anticancer Treatment for Gynecologic Malignancy?

Kajiyama Hiroaki, Utsumi Fumi, Higashi Makiko, Sakata Jun, Sekiya Ryuichiro, Mizuno Mika, Umezu Tomokazu, Suzuki Shiro, Yamamoto Eiko, Mitsui Hiroko, Niimi Kaoru, Shibata Kiyosumi, Kikkawa Fumitaka

JOURNAL OF PALLIATIVE MEDICINE Vol. 17 ( 3 ) page： 325 - 330 2014.3

Survival benefit of taxane plus platinum in recurrent ovarian cancer with non-clear cell, non-mucinous histology

Kajiyama Hiroaki, Shibata Kiyosumi, Mizuno Mika, Umezu Tomokazu, Suzuki Shiro, Sekiya Ryuichiro, Niimi Kaoru, Mitsui Hiroko, Yamamoto Eiko, Kawai Michiyasu, Nagasaka Tetsuro, Kikkawa Fumitaka

JOURNAL OF GYNECOLOGIC ONCOLOGY Vol. 25 ( 1 ) page： 43 - 50 2014.1

POSSIBLE INVOLVEMENT OF ENDOGLIN IN THE PATHOGENESIS OF PREGNANCY INDUCED HYPERTENSION

Mano Yukio, Ushida Takafumi, Hirako Shima, Moroi Hiroaki, Imai Kenji, Sawada Masako, Nakano Tomoko, Hattori Yuka, Watanabe Yuriko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Kotani Tomomi, Kikkawa Fumitaka

PLACENTA Vol. 34 ( 10 ) page： A14 - A14 2013.10

Altered Expression of Enzymes Regulating the Activity of Endothelin-1 in the Lower Segment of the Human Amnion During Labor

Kotani Tomomi, Iwase Akira, Tsuda Hiroyuki, Mano Yukio, Yamamoto Eiko, Nakano Tomoko, Hasegawa Yumi, Li Hua, Sumigama Seiji, Itakura Atsuo, Kikkawa Fumitaka

BIOLOGY OF REPRODUCTION Vol. 89 ( 3 ) page： 52 2013.9

An HLA-modified ovarian cancer cell line induced CTL responses specific to an epitope derived from claudin-1 presented by HLA-A*24:02 molecules

Kondo Shinji, Demachi-Okamura Ayako, Hirosawa Tomoya, Maki Hiroyuki, Fujita Mitsugu, Uemura Yasushi, Akatsuka Yoshiki, Yamamoto Eiko, Shibata Kiyosumi, Ino Kazuhiko, Kikkawa Fumitaka, Kuzushima Kiyotaka

HUMAN IMMUNOLOGY Vol. 74 ( 9 ) page： 1103 - 1110 2013.9

THE EXPRESSIONS OF ECE-1 AND NEP ARE REGULATED BY TLR-4 SIGNALLING IN GESTATIONAL TISSUES

Kotani Tomomi, Mano Yukio, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Li Hua, Watanabe Yuriko, Nakano Tomoko, Kikkawa Fumitaka

PLACENTA Vol. 34 ( 9 ) page： A43 - A43 2013.9

The expression and characterization of endoglin in uterine leiomyosarcoma

Mitsui Hiroko, Shibata Kiyosumi, Mano Yukio, Suzuki Shiro, Umezu Tomokazu, Mizuno Mika, Yamamoto Eiko, Kajiyama Hiroaki, Kotani Tomomi, Senga Takeshi, Kikkawa Fumitaka

CLINICAL & EXPERIMENTAL METASTASIS Vol. 30 ( 6 ) page： 731 - 740 2013.8

Anti-Mullerian hormone as a marker of ovarian reserve following chemotherapy in patients with gestational trophoblastic neoplasia

Iwase Akira, Sugita Atsuko, Hirokawa Wakana, Goto Maki, Yamamoto Eiko, Takikawa Sachiko, Nakahara Tatsuo, Nakamura Tomoko, Kondo Mika, Kikkawa Fumitaka

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY Vol. 167 ( 2 ) page： 194 - 198 2013.4

Expression of Twist enhances risk of poor oncologic outcome in patients with stage Ib to II cervical carcinoma with lymphovascular space involvement

Kajiyama Hiroaki, Shibata Kiyosumi, Umezu Tomokazu, Mizuno Mika, Suzuki Shiro, Yamamoto Eiko, Fujiwara Sawako, Kikkawa Fumitaka

HUMAN PATHOLOGY Vol. 44 ( 2 ) page： 181 - 188 2013.2

High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma

Niimi K., Yamamoto E., Fujiwara S., Shinjo K., Kotani T., Umezu T., Kajiyama H., Shibata K., Ino K., Kikkawa F.

BRITISH JOURNAL OF CANCER Vol. 107 ( 12 ) page： 1969 - 1977 2012.12

A case report of placental mesenchymal dysplasia with an increased VEGF-D expression

Kotani T., Sumigama S., Tsuda H., Mano Y., Yamamoto E., Iwase A., Shimoyama Y., Nagasaka T., Hayakawa H., Yamamoto T., Ino K., Kikkawa F.

PLACENTA Vol. 33 ( 10 ) page： 888 - 891 2012.10

MOLECULAR GENETIC DIAGNOSIS OF TWO RARE CASES OF GESTATIONAL TROPHOBLASTIC NEOPLASIA

Fujiwara Sawako, Yamamoto Eiko, Kan Momo, Niimi Kaoru, Shinjyo Kanako, Mano Yukio, Tsuda Hiroyuki, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

PLACENTA Vol. 33 ( 9 ) page： A107 - A107 2012.9

ROLE OF N-ACETYLGLUCOSAMINYLTRANSFERASE IVA IN CHORIOCARCINOMA

Niimi Kaoru, Yamamoto Eiko, Mano Yukio, Tsuda Hiroyuki, Sumigama Seiji, Shinjo Kanako, Fujiwara Sawako, Kotani Tomomi, Kikkawa Fumitaka

PLACENTA Vol. 33 ( 9 ) page： A50 - A50 2012.9

[The diagnosis and treatment for choriocarcinoma].

Yamamoto E, Fujiwara S, Kikkawa F

Nihon rinsho. Japanese journal of clinical medicine Vol. 70 Suppl 4 page： 727 - 32 2012.6

Expression of CXCR4 indicates poor prognosis in patients with clear cell carcinoma of the ovary

Sekiya Ryuichiro, Kajiyama Hiroaki, Sakai Kotaro, Umezu Tomokazu, Mizuno Mika, Shibata Kiyosumi, Yamamoto Eiko, Fujiwara Sawako, Nagasaka Tetsuro, Kikkawa Fumitaka

HUMAN PATHOLOGY Vol. 43 ( 6 ) page： 904 - 910 2012.6

Postrecurrent Oncologic Outcome of Patients With Ovarian Clear Cell Carcinoma

Kajiyama Hiroaki, Shibata Kiyosumi, Mizuno Mika, Yamamoto Eiko, Fujiwara Sawako, Umezu Tomokazu, Suzuki Shiro, Nakanishi Toru, Nagasaka Tetsuro, Kikkawa Fumitaka

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 22 ( 5 ) page： 801 - 806 2012.6

Normal human chorionic gonadotropin regression curves in uneventful postmolar patients.

Kizaki S, Matsui H, Usui H, Shozu M, Hanawa S, Yamamoto E, Kikkawa F

The Journal of reproductive medicine Vol. 57 ( 5-6 ) page： 243 - 8 2012.5

Long-Term Clinical Outcome of Patients With Recurrent Epithelial Ovarian Carcinoma Is it the Same for Each Histological Type?

Kajiyama Hiroaki, Shibata Kiyosumi, Mizuno Mika, Umezu Tomokazu, Suzuki Shiro, Yamamoto Eiko, Fujiwara Sawako, Kawai Michiyasu, Nagasaka Tetsuro, Kikkawa Fumitaka

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 22 ( 3 ) page： 394 - 399 2012.3

Prognostic factors in stage IA-IIA cervical cancer patients treated surgically: does the waiting time to the operation affect survival?

Umezu Tomokazu, Shibata Kiyosumi, Kajiyama Hiroaki, Yamamoto Eiko, Mizuno Mika, Kikkawa Fumitaka

ARCHIVES OF GYNECOLOGY AND OBSTETRICS Vol. 285 ( 2 ) page： 493 - 497 2012.2

Normal Human Chorionic Gonadotropin Regression Curves in Uneventful Postmolar Patients

Kizaki Shoko, Matsui Hideo, Usui Hirokazu, Shozu Makio, Hanawa Shinsuke, Yamamoto Eiko, Kikkawa Fumitaka

JOURNAL OF REPRODUCTIVE MEDICINE Vol. 57 ( 5-6 ) page： 243 - 248 2012

The Loss of Endoglin Promotes the Invasion of Extravillous Trophoblasts

Mano Yukio, Kotani Tomomi, Shibata Kiyozumi, Matsumura Hiroko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Iwase Akira, Senga Takeshi, Kikkawa Fumitaka

ENDOCRINOLOGY Vol. 152 ( 11 ) page： 4386 - 4394 2011.11

ENDOGLIN KNOCKDOWN ATTENUATED THE SUPPRESSIVE ROLE OF ANGIOTENSIN LL ON EXTAVILLOUS TROPHOBRAST INVASION

Hattori Yuka, Kotani Tomomi, Sumigama Seigi, Mano Yukio, Yamamoto Eiko, Fujiwara Sawako, Niimi Kaoru, Kikkawa Fumitaka

PLACENTA Vol. 32 ( 9 ) page： A63 - A63 2011.9

ESTABLISHMENT OF IMMORTALIZED HUMAN COMPLETE HYDATIDIFORM MOLE CELL LINES

Yamamoto Eiko, Niimi Kaoru, Shinjo Kanako, Fujiwara Sawako, Mano Yukio, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

PLACENTA Vol. 32 ( 9 ) page： A25 - A25 2011.9

N-ACETYLGLUCOSAMINYLTRANSFERASE IVA MAY REGULATE CELL INVASION IN CHORIOCARCINOMA

Niimi Kaoru, Yamamoto Eiko, Shinjo Kanako, Fujiwara Sawako, Mano Yukio, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

PLACENTA Vol. 32 ( 9 ) page： A57 - A57 2011.9

THE LOSS OF ENDOGLIN PROMOTES THE INVASION OF EXTRAVILLOUS TROPHOBLASTS BY THE INDUCTION OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR

Mano Yukio, Kotani Tomomi, Shibata Kiyosumi, Matsumura Hiroko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Iwase Akira, Senga Takeshi, Kikkawa Fumitaka

PLACENTA Vol. 32 ( 9 ) page： A57 - A57 2011.9

PLACENTA ACCRETA MIMICKING PLACENTAL SITE TROPHOBLASTIC TUMOR: A CASE REPORT

Fujiwara Sawako, Niimi Kaoru, Shinjyo Kanako, Yamamoto Eiko, Mano Yukio, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

PLACENTA Vol. 32 ( 9 ) page： A15 - A15 2011.9

PATHOLOGICAL INVESTIGATION OF PLACENTA PREVIA ACCRETA: THE SITE OF UTERINE WALL AND THE WIDTH/DEPTH OF VILLOUS INVASION

Sumigama Seiji, Kotani Tomomi, Mano Yukio, Hattori Yuka, Fujiwara Sawako, Yamamoto Eiko, Nagasaka Tetsurou, Kikkawa Fumitaka

PLACENTA Vol. 32 ( 9 ) page： A60 - A60 2011.9

The invasiveness of extravillous trophoblasts controlled by two bioactive lysophospholipids, S1P and LPA

Kotani Tomomi, Sumigama Seiji, Tsuda Hiroyuki, Mano Yukio, Sugiyama Chisato, Hironaka Masae, Kawachi Fumitaka, Watanabe Yuriko, Hattori Yuka, Yamamoto Eiko, Kikkawa Fumitaka

PLACENTA Vol. 32 ( 9 ) page： A166 - A166 2011.9

Role of the Renin-Angiotensin System in Gynecologic Cancers

Ino K., Shibata K., Yamamoto E., Kajiyama H., Nawa A., Mabuchi Y., Yagi S., Minami S., Tanizaki Y., Kobayashi A., Kikkawa F.

CURRENT CANCER DRUG TARGETS Vol. 11 ( 4 ) page： 405 - 411 2011.5

Role of the renin-angiotensin system in gynecologic cancers.

Ino K, Shibata K, Yamamoto E, Kajiyama H, Nawa A, Mabuchi Y, Yagi S, Minami S, Tanizaki Y, Kobayashi A, Kikkawa F

Current cancer drug targets Vol. 11 ( 4 ) page： 405 - 11 2011.5

Establishment of Cisplatin-Resistant Ovarian Yolk Sac Tumor Cells and Investigation of the Mechanism of Cisplatin Resistance Using This Cell Line

Shibata Kiyosumi, Umezu Tomokazu, Sakurai Maiko, Kajiyama Hiroaki, Yamamoto Eiko, Ino Kazuhiko, Nawa Akihiro, Kikkawa Fumitaka

GYNECOLOGIC AND OBSTETRIC INVESTIGATION Vol. 71 ( 2 ) page： 104 - 111 2011

Glypican-3 expression predicts poor clinical outcome of patients with early-stage clear cell carcinoma of the ovary

Umezu Tomokazu, Shibata Kiyosumi, Kajiyama Hiroaki, Yamamoto Eiko, Nawa Akihiro, Kikkawa Fumitaka

JOURNAL OF CLINICAL PATHOLOGY Vol. 63 ( 11 ) page： 962 - 966 2010.11

Growth-suppressing function of glypican-3 (GPC3) via insulin like growth factor II (IGF-II) signaling pathway in ovarian clear cell carcinoma cells

Sakurai Maiko, Shibata Kiyosumi, Umezu Tomokazu, Kajiyama Hiroaki, Yamamoto Eiko, Ino Kazuhiko, Nawa Akihiro, Kikkawa Fumitaka

GYNECOLOGIC ONCOLOGY Vol. 119 ( 2 ) page： 332 - 336 2010.11

ESTABLISHMENT OF AN IMMORTALIZED HUMAN COMPLETE HYDATIDIFORM MOLE CELL LINE BY RETROVIRAL INFECTION OF HTERT

Yamamoto Eiko, Hayashi Kanako, Niimi Kaoru, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

PLACENTA Vol. 31 ( 9 ) page： A154 - A154 2010.9

N-ACETYLGLUCOSAMINYLTRANSFERASE IVA REGULATES INVASIVENESS OF CHORIOCARCINOMA CELLS

Niimi K., Yamamoto E., Hayashi K., Sumigama S., Kotani T., Kikkawa F.

PLACENTA Vol. 31 ( 9 ) page： A153 - A153 2010.9

N-ACETYLGLUCOSAMINYLTRANSFERASE V REGULATES EXTRAVILLOUS TROPHOBLAST INVASION THROUGH GLYCOSYLATION OF alpha 5 beta 1 INTEGRIN

Yamamoto Eiko, Ino Kazuhiko, Inaba Tomoko, Sumigama Seiji, Kikkawa Tomomi Kotani Furnitaka

PLACENTA Vol. 31 ( 9 ) page： A154 - A154 2010.9

Fertility-sparing operation for recurrence of uterine cervical perivascular epithelioid cell tumor.

Yamamoto E, Ino K, Sakurai M, Takigawa S, Iwase A, Kikkawa F

Rare tumors Vol. 2 ( 2 ) page： e26 2010.6

Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy

Inaba Tomoko, Ino Kazuhiko, Kajiyamaa Hiroaki, Shibata Kiyosumi, Yamamoto Eiko, Kondo Shinji, Umezu Tomokazu, Nawa Akihiro, Takikawa Osamu, Kikkawa Fumitaka

GYNECOLOGIC ONCOLOGY Vol. 117 ( 3 ) page： 423 - 428 2010.6

Enhanced cytotoxicity with a novel system combining the paclitaxel-2 '-ethylcarbonate prodrug and an HSV amplicon with an attenuated replication-competent virus, HF10 as a helper virus

Ishida Daisuke, Nawa Akihiro, Tanino Tadatoshi, Goshima Fumi, Luo Chen Hong, Iwaki Masahiro, Kajiyama Hiroaki, Shibata Kiyosumi, Yamamoto Eiko, Ino Kazuhiko, Tsurumi Tatsuya, Nishiyama Yukihiro, Kikkawa Fumitaka

CANCER LETTERS Vol. 288 ( 1 ) page： 17 - 27 2010.2

Gene silencing of glypican-3 in clear cell carcinoma of the ovary renders it more sensitive to the apoptotic agent paclitaxel in vitro and in vivo

Umezu Tomokazu, Shibata Kiyosumi, Shimaoka Maiko, Kajiyama Hiroaki, Yamamoto Eiko, Ino Kazuhiko, Nawa Akihiro, Senga Takeshi, Kikkawa Fumitaka

CANCER SCIENCE Vol. 101 ( 1 ) page： 143 - 148 2010.1

Endometrial Cancer: Indoleamine 2,3-Dioxygenase as a Prognostic Indicator

Ino Kazuhiko, Yamamoto Eiko, Shibata Kiyosumi, Kajiyama Hiroaki, Nawa Akihiro, Kikwa Fumitaka

METHODS OF CANCER DIAGNOSIS, THERAPY, AND PROGNOSIS, VOL 6 Vol. 6 page： 285 - 295 2010

Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells

Morimitsu Akiko, Sumigama Seiji, Kotani Tomomi, Mano Yukio, Suzuki Kanako, Araki-Taguchi Masako, Yamamoto Eiko, Hayakawa Hiromi, Okada Mayumi, Itakura Atsuo, Kikkawa Fumitaka

GYNECOLOGIC AND OBSTETRIC INVESTIGATION Vol. 69 ( 1 ) page： 67 - 72 2010

High expression of N-acetylglucosaminyltransferase V in mucinous tumors of the ovary

Takahashi Noriko, Yamamoto Eiko, Ino Kazuhiko, Miyoshi Eiji, Nagasaka Tetsuro, Kajiyama Hiroaki, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka

ONCOLOGY REPORTS Vol. 22 ( 5 ) page： 1027 - 1032 2009.11

Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma

Inaba Tomoko, Ino Kazuhiko, Kajiyama Hiroaki, Yamamoto Eiko, Shibata Kiyosumi, Nawa Akihiro, Nagasaka Tetsuro, Akimoto Hidetoshi, Takikawa Osamu, Kikkawa Fumitaka

GYNECOLOGIC ONCOLOGY Vol. 115 ( 2 ) page： 185 - 192 2009.11

Activator Protein-2 Impairs the Invasion of a Human Extravillous Trophoblast Cell Line

Kotani Tomomi, Iwase Akira, Ino Kazuhiko, Sumigama Seiji, Yamamoto Eiko, Hayakawa Hiromi, Nagasaka Tetsuo, Itakura Atsuo, Nomura Seiji, Kikkawa Fumitaka

ENDOCRINOLOGY Vol. 150 ( 9 ) page： 4376 - 4385 2009.9

Effectiveness of preoperative concurrent chemoradiation therapy (CCRT) for locally advanced adenocarcinoma of cervix

Shibata K., Kajiyama H., Yamamoto E., Terauchi M., Ino K., Nomura S., Nawa A., Kawai M., Kikkawa F.

EJSO Vol. 35 ( 7 ) page： 768 - 772 2009.7

N-Acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of alpha 5 beta 1 Integrin

Yamamoto Eiko, Ino Kazuhiko, Miyoshi Eiji, Inamori Kei-ichiro, Abe Akihiro, Sumigama Seiji, Iwase Akira, Kajiyama Hiroaki, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka

ENDOCRINOLOGY Vol. 150 ( 2 ) page： 990 - 999 2009.2

Tocilizumab Inhibits Interleukin-6-Mediated Matrix Metalloproteinase-2 and-9 Secretions from Human Amnion Cells in Preterm Premature Rupture of Membranes

Mano Yukio, Shibata Kiyosumi, Sumigama Seiji, Hayakawa Hiromi, Ino Kazuhiko, Yamamoto Eiko, Kajiyama Hiroaki, Nawa Akihiro, Kikkawa Fumitaka

GYNECOLOGIC AND OBSTETRIC INVESTIGATION Vol. 68 ( 3 ) page： 145 - 153 2009

Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary?

Kajiyama Hiroaki, Shibata Kiyosumi, Suzuki Shiro, Ino Kazuhiko, Yamamoto Eiko, Mizuno Kimio, Sakakibara Katsumi, Matsuzawa Katsuji, Takeda Akihiro, Kinoshita Yoshito, Kawai Michiyasu, Nagasaka Tetsuro, Nawa Akihiro, Kikkawa Fumitaka

GYNECOLOGIC ONCOLOGY Vol. 111 ( 3 ) page： 523 - 526 2008.12

Overexpression of Indoleamine 2,3-Dioxygenase in Human Endometrial Carcinoma Cells Induces Rapid Tumor Growth in a Mouse Xenograft Model

Yoshida Norio, Ino Kazuhiko, Ishida Yoshiyuki, Kajiyama Hiroaki, Yamamoto Eiko, Shibata Kiyosumi, Terauchi Mikio, Nawa Akihiro, Akimoto Hidetoshi, Takikawa Osamu, Isobe Ken-ichi, Kikkawa Fumitaka

CLINICAL CANCER RESEARCH Vol. 14 ( 22 ) page： 7251 - 7259 2008.11

N-ACETYLGLUCOSAMINVLTRANSFERASE V REGULATES EXTRAVILLOUS TROPHOBLAST INVASION THROUGH GLUCOSYLATION OF alpha 5 beta 1 INTEGTIN

Yamamoto Eiko, Ino Kazuhiko, Inaba Tomoko, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

PLACENTA Vol. 29 ( 10 ) page： 916 - 916 2008.10

Expression of the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) in human normal and malignant invasive trophoblastic cells

Ino K., Yamamoto E., Kidokoro K., Kikkiawa F.

PLACENTA Vol. 29 ( 8 ) page： A94 - A94 2008.8

N-acetylglucosminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alfa5-beta1 integrin

Yamamoto Eiko, Ino Kazuhiko, Kidokoro Kumiko, Takahashi Noriko, Inaba Tomoko, Kikkawa Fumitaka

PLACENTA Vol. 29 ( 8 ) page： A85 - A85 2008.8

Feasibility and effectiveness of postoperative adjuvant concurrent chemoradiation therapy in Japanese patients with high-risk early-stage cancer of the uterine cervix

Shibata Kiyosumi, Kajiyama Hiroaki, Terauchi Mikio, Yamamoto Eiko, Ino Kazuhiko, Nawa Akihiro, Kikkawa Fumitaka

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 13 ( 3 ) page： 233 - 238 2008.6

Inverse correlation between tumoral indoleamine 2,3-dioxygenase expression and tumor-infiltrating lymphocytes in endometrial cancer: Its association with disease progression and survival

Ino Kazuhiko, Yamamoto Eiko, Shibata Kiyosumi, Kajiyama Hiroaki, Yoshida Norio, Terauchi Mikio, Nawa Akihiro, Nagasaka Tetsuro, Takikawa Osamu, Kikkawa Fumitaka

CLINICAL CANCER RESEARCH Vol. 14 ( 8 ) page： 2310 - 2317 2008.4

Gene directed enzyme prodrug therapy for ovarian cancer: Could GDEPT become a promising treatment against ovarian cancer?

Nawa Akihiro, Tanino Tadatoshi, Luo ChenHong, Iwaki Masahiro, Kajiyama Hiroaki, Shibata Kiyosumi, Yamamoto Eiko, Ino Kazuhiko, Nishiyama Yukihiro, Kikkawa Fumitaka

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY Vol. 8 ( 2 ) page： 232 - 239 2008.2

Gene directed enzyme prodrug therapy for ovarian cancer: could GDEPT become a promising treatment against ovarian cancer?

Nawa A, Tanino T, Luo C, Iwaki M, Kajiyama H, Shibata K, Yamamoto E, Ino K, Nishiyama Y, Kikkawa F

Anti-cancer agents in medicinal chemistry Vol. 8 ( 2 ) page： 232 - 9 2008.2

Angiotensin II mimics the hypoxic effect on regulating trophoblast proliferation and differentiation in human placental explant cultures

Araki-Taguchi Masako, Nomura Seiji, Ino Kazuhiko, Sumigama Seiji, Yamamoto Eiko, Kotani-Ito Tomomi, Hayakawa Hiromi, Kajiyama Hiroaki, Shibata Kiyosumi, Itakura Atsuo, Kikkawa Fumitaka

LIFE SCIENCES Vol. 82 ( 1-2 ) page： 59 - 67 2008.1

Neuroendocrine tumor in the breast

Ogawa Hiroshi, Nishio Akiko, Satake Hiroko, Naganawa Shinji, Imai Tsuneo, Sawaki Masataka, Yamamoto Eiko, Miyata Tomoko

RADIATION MEDICINE Vol. 26 ( 1 ) page： 28 - 32 2008.1

Twist expression in patients with cervical cancer is associated with poor disease outcome

Shibata K., Kajiyama H., Ino K., Terauchi M., Yamamoto E., Nawa A., Nomura S., Kikkawa F.

ANNALS OF ONCOLOGY Vol. 19 ( 1 ) page： 81 - 85 2008.1

Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of nkx2.5 in tumor development

Shibata Kiyosumi, Kajiyama Hiroaki, Yamamoto Eiko, Terauchi Mikio, Ino Kazuhiko, Nawa Akihiro, Kikkawa Fumitaka

ONCOLOGY Vol. 74 ( 1-2 ) page： 104 - 111 2008

Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis

Yamamoto E., Ino K., Miyoshi E., Shibata K., Takahashi N., Kajiyama H., Nawa A., Nomura S., Nagasaka T., Kikkawa F.

BRITISH JOURNAL OF CANCER Vol. 97 ( 11 ) page： 1538 - 1544 2007.11

Involvement of oligosaccharide changes in alpha 5 beta 1 integrin in invasion of extravillous trophoblasts

Yamamoto Eiko, Ino Kazuhiko, Kidokoro Kumiko, Takahashi Noriko, Yoshida Norio, Nakagawa Akiko, Sumigama Seiji, Kikkawa Fumitaka

PLACENTA Vol. 28 ( 10 ) page： A5 - A5 2007.10

Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma

Terauchi Mikio, Kajiyama Hiroaki, Yamashita Mamoru, Kato Mikihiko, Tsukamoto Hirohisa, Umezu Tomokazu, Hosono Satoyo, Yamamoto Eiko, Shibata Kiyosumi, Ino Kazuhiko, Nawa Akihiro, Nagasaka Tetsuro, Kikkawa Fumitaka

CLINICAL & EXPERIMENTAL METASTASIS Vol. 24 ( 5 ) page： 329 - 339 2007.9

A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature

Yamamoto E., Ino K., Yamamoto T., Sumigama S., Nawa A., Nomura S., Kikkawa F.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 17 ( 1 ) page： 254 - U1 2007

Genetically identified complete hydatidiform mole coexisting with a live twin fetus: Comparison with conventional diagnosis

Sumigama Seiji, Itakura Atsuo, Yamamoto Toshimichi, Nagasaka Tetsuro, Yamamoto Eiko, Ino Kazuhiko, Kikkawa Fumitaka

GYNECOLOGIC AND OBSTETRIC INVESTIGATION Vol. 64 ( 4 ) page： 228 - 231 2007

Involvement of oligosaccharide changes in 51 integrin in migration of extravillous trophoblasts

Yamamoto E., Ino K., Sumigama S., Nomura S., Kikkawa F.

PLACENTA Vol. 28 ( 8-9 ) page： A61 - A61 2007

Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer

Ino K., Yoshida N., Kajiyama H., Shibata K., Yamamoto E., Kidokoro K., Takahashi N., Terauchi M., Nawa A., Nomura S., Nagasaka T., Takikawa O., Kikkawa F.

BRITISH JOURNAL OF CANCER Vol. 95 ( 11 ) page： 1555 - 1561 2006.12

Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells

Shido F, Ito T, Nomura S, Yamamoto E, Sumigama S, Ino K, Itakura A, Hattori A, Tsujimoto M, Mizutani S, Kikkawa F

ENDOCRINOLOGY Vol. 147 ( 4 ) page： 1780 - 1788 2006.4

Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumour angiogenesis and patient survival

Ino K, Shibata K, Kajiyama H, Yamamoto E, Nagasaka T, Nawa A, Nomura S, Kikkawa F

BRITISH JOURNAL OF CANCER Vol. 94 ( 4 ) page： 552 - 560 2006.2

Twist expression predicts poor clinical outcome of patients with clear cell carcinoma of the ovary

Kajiyama Hiroaki, Hosono Satoyo, Terauchi Mikio, Shibata Kiyosumi, Ino Kazuhiko, Yamamoto Eiko, Nomura Seiji, Nawa Akihiro, Kikkawa Fumitaka

ONCOLOGY Vol. 71 ( 5-6 ) page： 394 - 401 2006

Expression of indoleamine 2,3-dioxygenase in human extravillous trophoblasts using first-trimester villous explant cultuers and the extravillous trophobalst cell line

Kidokoro K., Ino K., Yamamoto E., Takahashi N., Yoshida N., Nomura S., Kikkawa F.

PLACENTA Vol. 27 ( 9-10 ) page： A28 - A28 2006

Dual induction of indoleamine 2,3-dioxygenase and HLA-G by interferon-gamma in human extravillous trophoblasts: Its implication in tolerance at the fetal-maternal interface

Ino K., Kidokoro K., Yamamoto E., Takahashi N., Yoshida N., Nomura S., Kikkawa F.

PLACENTA Vol. 27 ( 9-10 ) page： A29 - A29 2006

Sphingosine 1-phosphate and its receptors influence on trophoblast migration

Sumigama Seiji, Kotani Tomomi, Yamamoto Eiko, Hayakawa Hiromi, Okada Mayumi, Kikkawa Fumitaka

PLACENTA Vol. 27 ( 9-10 ) page： A22 - A22 2006

The expression of N-acetylglucosaminyltransferase v in human placenta

Yamamoto E., Mo K., Kidokoro K., Takahashi N., Nomura S., Kikkawa F.

PLACENTA Vol. 27 ( 9-10 ) page： A28 - A28 2006

Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion

Yamamoto E, Ito T, Abe A, Sido F, Ino K, Itakura A, Mizutani S, Dovat S, Nomura S, Kikkawa F

MOLECULAR HUMAN REPRODUCTION Vol. 11 ( 11 ) page： 825 - 831 2005.11

ADAM (a disintegrin and metalloproteinase)-12 mediate shedding of oxytocinase

Nomura S, Ito N, Iwase A, Kidokoro K, Takahashi N, Yoshida N, Yamamoto E, Ito-Kotani T, Ino K, Kikkawa F

PLACENTA Vol. 26 ( 10 ) page： A8 - A8 2005.11

Immunohistochemical expression of indoleamine 2,3-dioxygenase in gestational trophoblastic neoplasia

Ino K, Yoshida N, Kidokoro K, Takahashi N, Yamamoto E, Nomura S, Kikkawa F

PLACENTA Vol. 26 ( 10 ) page： A5 - A5 2005.11

Gene regulation and physiological function of placental leucine arninopeptidase/oxytocinase during pregnancy

Nomura S, Ito T, Yamamoto E, Sumigama S, Iwase A, Okada M, Shibata K, Ando H, Ino K, Kikkawa F, Mizutani S

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS Vol. 1751 ( 1 ) page： 19 - 25 2005.8

Expression of indoleamine 2,3-dioxygenase (IDO) in neoplastic trophoblasts of gestational trophoblastic neoplasia.

Ino K, Yamamoto E, Ito T, Kajiyama H, Shibata K, Nomura S, Kikkawa F

PLACENTA Vol. 26 ( 8-9 ) page： A37 - A37 2005

Trnascriptional factor Ikaros-x might be involved in migratory and invasne ability in extravillous trophoblasts

Yamamoto E, Ito T, Graham CH, Ino K, Nomura S, Kikkawa F

PLACENTA Vol. 26 ( 8-9 ) page： A61 - A61 2005

Ikaros regulates invasiveness of human extravillous trophoblast

Yamamoto E, Ito T, Shido F, Sumigama S, Nomura S, Kikkawa F

PLACENTA Vol. 25 ( 10 ) page： A2 - A2 2004.11

Oxytocinase gene regulation by AP-2alpha with trophoblast differentiation

Nomura S, Ito T, Shido F, Yamamoto E, Ino K, Kikkawa F

PLACENTA Vol. 25 ( 10 ) page： A2 - A2 2004.11

The endoplasmic reticulum aminopeptidase, ERAP1 is involved in expression of membrane HLA-G and soluble HLA-G on trophoblast cells by leukemia inhibitory factor

Shido F, Ito T, Nomura S, Yamamoto E, Sumigama S, Ino K, Itakura A, Mizutani S, Kikkawa F

PLACENTA Vol. 25 ( 10 ) page： A3 - A3 2004.11

Placental leucine aminopeptidase/oxytocinase gene regulation by activator protein-2 in BeWo cell model of human trophoblast differentiation

Iwanaga K, Nomura S, Ito T, Ikoma Y, Yamamoto E, Okada M, Itakura A, Kikkawa F, Tsujimoto M, Mizutani S

FEBS LETTERS Vol. 552 ( 2-3 ) page： 120 - 124 2003.9

Effects of postmenopausal hormone replacement therapy on HbA(1c) levels.

Okada M, Nomura S, Ikoma Y, Yamamoto E, Ito T, Mitsui T, Tamakoshi K, Mizutani S

Diabetes care Vol. 26 ( 4 ) page： 1088 - 92 2003.4

Effects of postmenopausal hormone replacement therapy on HbA(1c) levels

Okada M, Nomura S, Ikoma Y, Yamamoto E, Ito T, Mitsui T, Tamakoshi K, Mizutani S

DIABETES CARE Vol. 26 ( 4 ) page： 1088 - 1092 2003.4

Elucidation of the role of XBP1 in the progression of complete hydatidiform mole to invasive mole through RNA-seq. Reviewed International coauthorship International journal

Mayu Shibata, Kosuke Yoshida, Akira Yokoi, Hironori Suzuki, Yusuke Yamamoto, Masami Kitagawa, Eri Asano-Inami, Yuko Yasui, Yuki Nishiko, Masato Yoshihara, Satoshi Tamauchi, Nobuhisa Yoshikawa, Kimihiro Nishino, Eiko Yamamoto, Kaoru Niimi, Hiroaki Kajiyama

Gynecologic oncology Vol. 190 page： 189 - 199 2024.11

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: A complete hydatidiform mole (CHM) is a common disease and is known to develop post-molar gestational trophoblast neoplasia (GTN). However, the molecular mechanisms underlying the progression of CHM to post-molar GTN remain largely unknown. In this study, we investigated the molecular factors associated with the progression using RNA-seq. METHODS: We included 13 patients with CHM and performed RNA-seq using freshly frozen samples. We identified differentially expressed genes between patients who developed GTN (GTN group) and those who achieved spontaneous remission after uterine evacuation (SR group), and performed pathway analysis. Then, functional analyses were performed on choriocarcinoma (JAR and JEG-3) and CHM (Hmol1-3B and Hmol1-2C) cells. Moreover, we evaluated the in vivo tumorigenicity of XBP1-overexpressed Hmol1-3B cells. RESULTS: The gene expression profiles were separated into two groups, and an upstream regulator analysis was performed using 281 differentially expressed genes. We focused on transcription factors and identified that 33 transcription factors were activated in the GTN group. Then, excluding those with low expression levels in clinical samples and cell lines, XBP1 was selected for further analysis. Additionally, XBP1 downregulation significantly decreased the migration and invasive abilities of choriocarcinoma cells, whereas XBP1 overexpression significantly increased the migration and invasive abilities of CHM cells. Furthermore, animal experiments showed that tumor weight and blood human chorionic gonadotropin (hCG) levels were significantly higher in the XBP1-overexpressing Hmol1-3B-bearing mice than those in the control mice. CONCLUSION: RNA-seq identified XBP1 as a key factor in post-molar GTN, suggesting it contributes to the development of post-molar GTN.

DOI： 10.1016/j.ygyno.2024.08.023

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Infection prevention and control status at public hospitals and factors associated with COVID-19 infection among healthcare workers in Myanmar: A cross-sectional study Reviewed International coauthorship International journal Open Access

Thet Mon Than, Moe Khaing, Nobuyuki Hamajima, Yu Mon Saw, Yamin Thaung, Thinzar Aung, Ei Mon Win, Souphalak Inthaphatha, Kimihiro Nishino, Eiko Yamamoto

BMC Infectious Diseases Vol. 24 ( 1 ) page： 956 2024.9

Characteristics of adverse drug reactions due to nonsteroidal anti-inflammatory drugs: a cross-sectional study.

Cholticha Sonsupap, Pattreya Pokhakul, Tetsuyoshi Kariya, Yunosuke Suzuki, Nobuyuki Hamajima, Eiko Yamamoto

Nagoya journal of medical science Vol. 85 ( 4 ) page： 668 - 681 2023.11

Language：English Publishing type：Research paper (scientific journal)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for treating pain and inflammation. Spontaneous adverse drug reaction (ADR) reports represent a rich data source for the detection of unknown and rare ADRs. This cross-sectional study aimed to analyze the characteristics of ADRs due to NSAIDs in Thailand. All ADR reports of NSAIDs for systemic use from 2015 to 2019 were extracted from the national database in Thailand. Patient characteristics, drug use information, adverse event information, and source of senders in 32,857 reports were analyzed. The annual number of ADR reports due to NSAIDs decreased from 7,008 in 2015 to 5,922 in 2019. The most frequently reported drug was ibuprofen (n=12,645, 38.5%) followed by diclofenac (n=7,795, 23.7%), most patients were 40-59 years old, and the major adverse reaction was angioedema (n=7,513, 22.9%). Serious reactions were recorded in 20.7% (n=6,801) of the total ADRs. Most patients (n=20,593, 62.7%) recovered without sequelae, but there were 5,420 patients (16.5%) who could not recover and 3,109 patients (9.5%) who were recovering. Eight patients (0.02%) died of Stevens-Johnson syndrome (n=3), toxic epidermal necrolysis (n=4), and anaphylactic shock (n=1), which were possibly related to ADRs. The number of ADR reports due to NSAIDs decreased from 2015 to 2019 in Thailand. Serious ADRs and death cases accounted for 20.7% and 0.02%, respectively. Most fatal cases exhibited severe drug-induced skin reactions.

DOI： 10.18999/nagjms.85.4.668

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Period shaming behavior among male students in Luang Prabang Province, Lao People's Democratic Republic: A cross-sectional study. International journal

Souphalak Inthaphatha, Leyla Isin-Xiong, Viengsakhone Louangpradith, Valee Xiong, Vue Xaitengcha, Alongkone Phengsavanh, Kimihiro Nishino, Nobuyuki Hamajima, Eiko Yamamoto

PloS one Vol. 18 ( 7 ) page： e0288145 2023.7

Language：English Publishing type：Research paper (scientific journal)

Period shaming is defined as any negative and/or disrespectful behavior in relation to the menstrual cycle and menstruating girls. It is suggested that period shaming may limit girls' potential and ability to fully participate in school and community activities. This study aims to examine the prevalence and factors associated with period shaming among male students in Luang Prabang Province, Lao People's Democratic Republic (Lao PDR). This was a cross-sectional study which was conducted during November 19-27, 2020. This study included 1,232 male students from secondary school grade 9 to 12 in Luang Prabang Province, Lao PDR. Informed consent was obtained from the participants, parents/guardians, and teachers prior to data collection. The data was collected by a self-administered questionnaire. Logistic regression was employed to examine factors associated with period shaming behavior among male students. The mean age of the participants was 16.4 years old. Of all the male students, 18.8% admitted that they had shamed girls during their menstruation at least once. Of those who committed period shaming, they shamed girls some of the times (63.2%). Male students who had consumed alcohol during the last month before the data collection day (AOR = 1.83, 95% CI 1.32-2.55, P<0.001), had heard of menstruation (AOR = 1.76, 95% CI 1.27-2.44, P<0.001), and those who had attended activities/classes about sexual reproductive health (AOR = 1.90, 95% CI 1.29-2.78, P<0.01), were significantly associated with period shaming behavior. In conclusion, a single focus on providing biological health education may not be enough to address menstrual stigmatization and taboos. The school curriculum should integrate other life skill education with reproductive health, such as respect and gender equality, to encourage behavioral changes among male students, to address menstrual stigma and to support and empower girls' menstrual health at school and in the community.

DOI： 10.1371/journal.pone.0288145

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Causes of death, three delays, and factors associated with Delay 1 among maternal deaths in Myanmar: The maternal death surveillance in 2019. International journal

Khine Khine Tun, Souphalak Inthaphatha, Myint Moh Soe, Kimihiro Nishino, Nobuyuki Hamajima, Eiko Yamamoto

Midwifery Vol. 121 page： 103657 - 103657 2023.6

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The maternal mortality ratio (MMR) in Myanmar was the highest in Southeast Asia in 2017. The Three Delay Model is used to evaluate delays that contribute to maternal deaths. This study aims to identify MMR, causes of death, the three delays related to maternal deaths, and the factors associated with Delay 1, which is the time of delay in deciding to seek health care (from the start of the woman's illness to the time when the problem is recognized to be requiring care), in Myanmar. STUDY DESIGN: A cross-sectional study. PARTICIPANT: This study included 934 cases of maternal deaths reported from all states and regions throughout Myanmar in 2019 that were not caused by accidents and injuries. MATERIALS AND METHODS: Socio-demographic factors, obstetrical factors, information about deaths, and assessment of delays were obtained from the Maternal Death Surveillance and Response System, the database of maternal deaths. Distribution of maternal deaths by states and regions, causes of maternal death, and types of delay that contributed to maternal deaths were descriptively summarized. Logistic regression analysis was performed to identify factors associated with Delay 1 among 567 maternal deaths without any missing data and unknown information on delays. FINDINGS: In 2019, the MMR was 106 (95% confidence interval, 99-112) per 100,000 live births. Of the 934 maternal deaths, 80.5% of deaths had at least one delay, and Delay 1 was the major delay (72.9%). Eclampsia/pre-eclampsia (21.6%), postpartum hemorrhage (18.2%), and abortion-related complications (13.2%) were the major causes of maternal death. The husband's low education, low household income, unplanned pregnancy, and no antenatal care were associated with Delay 1. KEY CONCLUSIONS AND IMPLICATION FOR PRACTICE: The MMR was lower in 2019 than that in 2017 but remained high. Moreover, we demonstrate that most maternal deaths had at least one delay, mostly Delay 1. To prevent maternal deaths caused by Delay 1, the family planning should be promoted to prevent unplanned pregnancies. Educational training for healthcare providers who deliver antenatal care should be strengthened. Furthermore, education on the danger signs of pregnancy and during childbirth should be provided not only to pregnant women and their husbands in communities at health facilities.

DOI： 10.1016/j.midw.2023.103657

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Assessment of the underlying causes of adult deaths using a short version of verbal autopsy in Xaiyabouli Province, Lao People's Democratic Republic. International journal

Bounbouly Thanavanh, Nobuyuki Hamajima, Kaiyason Sida, Kene Duangdy, Lasavong Latsamy, Khounsavath Senaphane, Viengsakhone Louangpradith, Souphaphone Sadettan, Souphalak Inthaphatha, Kimihiro Nishino, Eiko Yamamoto

BMC public health Vol. 23 ( 1 ) page： 560 - 560 2023.3

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: In developing countries, it is difficult to collect the data of the underlying cause of death (UCOD), especially when a death does not occur in a health facility. This study aimed to develop a short version of verbal autopsy (VA) and identify the UCOD of adults in Lao People's Democratic Republic (Lao PDR). METHODS: A short version of VA for deaths outside health facilities was developed. This study included all deaths of people aged 15 years old or older in Xaiyabouli Province in 2020. Socio-demographic factors, place of death, and UCOD of the deceased were collected from health facilities or from family members using a questionnaire including the short VA form. UCOD was compared between home deaths and hospital deaths, between the age group of 15-59 years old and the age group ≥ 60 years old, and between males and females. RESULTS: Of all the 1,235 deaths included in this study, 1,012 deaths (81.9%) occured at home and 223 deaths (18.1%) at hospitals. The most common UCOD was senility (13.3%), followed by heart/renal failure (10.5%), pneumonia (9.6%) and traffic accident (7.1%). Compared to hospital deaths, home deaths had more people who were females, 75 years old or older, and Lao-Tai. Home deaths had more deaths than hospital deaths due to accident/injury (16.0% vs. 8.1%), tumor (4.7% vs. 1.8%), and senility (16.2% vs. 0%); fewer deaths due to heart/renal disease (15.1% vs. 32.3%), respiratory disease (12.2% vs. 18.8%), liver/gastro-intestine disease (5.3% vs. 9.0%), and infection (3.1% vs. 14.3%). The age group of 15-59 years had more deaths in the categories of accident/injury (28.1% vs. 4.4%), liver/gastro-intestine disease (8.1% vs. 4.4%), infection (7.2% vs. 3.5%), and tumor (6.0% vs. 2.8%). Males had more deaths due to tumor (5.2% vs. 3.0%) and fewer natural deaths (11.2% vs. 15.9%) than females. CONCLUSIONS: The major UCOD category was heart/renal disease in the adult generation in Xaiyabouli Province. Cost-effective interventions based on the multisectoral noncommunicable disease prevention plan should be appropriately implemented. Mortality surveillance using the short VA tool should be conducted for all home deaths in Lao PDR.

DOI： 10.1186/s12889-023-15469-2

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Reporting system on mortality statistics in Lao People's Democratic Republic.

Souphalak Inthaphatha, Viengsakhone Louangpradith, Bounfeng Phoummalaysith, Bounbouly Thanavanh, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

Nagoya journal of medical science Vol. 85 ( 1 ) page： 113 - 122 2023.2

Language：English Publishing type：Research paper (scientific journal)

The system to collect information on mortality statistics in Lao PDR is not well established, accurate and timely death information is therefore not available. This article reports the system and process to make the mortality statistical data of Lao PDR. The country has a paper-based resident registration system, using a death notification document, a death certificate, and a family census book. The death notification document is important as it provides the cause of death, which is issued from a health facility and the village office. In the event of a death occurring at home, the family representative needs to report to the village office verbally to obtain a death notification document. On the other hand, if the death occurred in a medical facility, a death notification document from a health facility is provided. The family representative should bring the death notification document to the district Home Affairs office to register the death and obtain a death certificate. After that, the family representative needs to bring the death certificate to the district Public Security office for an amendment in the family census book. ICD-10 is under development regarding death notification from health facilities under the Ministry of Health. However, it is unclear how death notification from village offices can adopt ICD-10 as the majority of deaths occur outside health facilities. A comprehensive and integrated mortality reporting system is necessary in order to create a holistic health policy and welfare for the country.

DOI： 10.18999/nagjms.85.1.113

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Factors associated with positive cancer screening for the uterine cervix and breast in Jakarta Province, Indonesia: a cross-sectional study. International journal

Lady Margaretha Febriany Sirait, Nobuyuki Hamajima, Yunosuke Suzuki, Endang Sri Wahyuningsih, Dwi Oktavia, Widyastuti, Souphalak Inthaphatha, Kimihiro Nishino, Eiko Yamamoto

BMC cancer Vol. 22 ( 1 ) page： 1309 - 1309 2022.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: In many middle-income countries, cancer incidence and mortality are rapidly increasing, but data for developing a strategy of cancer control are rarely collected or analyzed. This study aimed to identify factors associated with positive cancer screening for the uterine cervix and breast in Jakarta Province, Indonesia. METHODS: The data of 79,660 women who had visual inspection with acetic acid (VIA) and 83,043 women who had clinical breast examination (CBE) in the Jakarta Women Cancer Screening program in 2019 were included in this study. Socio-demographic factors, reproductive factors, lifestyle factors, family history, and the results of VIA and CBE were used for analyses. Binary and multivariate logistic regression analyses were performed to identify factors associated with VIA positive or CBE positive. RESULTS: The positive rate was 0.9% for both VIA and CBE among the screening participants. Factors associated with VIA positive were age < 30 years old, age at menarche ≤ 11 years old, remarriage, lower educational level, having an occupation, partner's occupation other than being an employee, alcohol consumption, smoker, inadequate physical activity, cancer family history, and no Pap smear history. Factors associated with CBE positive were age at menarche ≤ 11 years old, widowed, high education, having an occupation, no breastfeeding history, birth control history, alcohol consumption, smoker, inadequate physical activity, cancer family history, and breast tumor history. CONCLUSION: Factors associated with VIA positive and CBE positive among Indonesian women were revealed. To promote female cancer prevention in Indonesia, the prevalence of screenings should be increased and education about the risk factors should be provided to medical professionals.

DOI： 10.1186/s12885-022-10381-1

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Epidemiologic study on gestational trophoblastic diseases in Japan. International journal

Eiko Yamamoto, Kimihiro Nishino, Kaoru Niimi, Kazuhiko Ino

Journal of gynecologic oncology Vol. 33 ( 6 ) page： e72 2022.11

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: This study aims to estimate the population-based incidence of gestational trophoblastic diseases (GTDs) and to identify the characteristics of gestational trophoblastic neoplasia (GTN) in Japan. METHODS: The annual number of GTD and live births from 1974 to 2018 were used to estimate the incidence of GTD. The data of 1,574 GTN cases from 1999 to 2018 were analyzed to identify the characteristics of low-risk GTN, high-risk GTN, placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). RESULTS: The incidence of hydatidiform mole was 2.02 per 1,000 live births on average which decreased from 1974 to 2008 and increased from 2009 to 2018. The incidence of low-risk GTN, high-risk GTN, PSTT, and ETT was 15.3, 3.5, 0.3, and 0.07 per 100,000 live births, respectively. The estimated incidence of post-molar GTN was 9.8% of molar patients. High-risk GTN was diagnosed more pathologically, had more various kinds of antecedent pregnancies, and had longer intervals after the antecedent pregnancy compared to low-risk GTN. Furthermore, 8.2% of high-risk GTN occurred after the subsequent non-molar pregnancy of hydatidiform mole. The cumulative percentage of developing high-risk GTN after hydatidiform mole reached 89.3% at the 60th month. CONCLUSION: The incidence of hydatidiform mole, low-risk GTN, high-risk GTN was 2.02 per 1,000 live births, 15.3 per 100,000 live births, and 3.5 per 100,000 live births, respectively. High-risk GTN was diagnosed more pathologically and later after the antecedent pregnancy than low-risk GTN. Following molar patients for five years is needed to improve the mortality of malignant GTN.

DOI： 10.3802/jgo.2022.33.e72

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Children with neuro-developmental disorders at Center for Child and Adolescent Mental Health in Cambodia.

Sreyleap Moeun, Jegannathan Bhoomikumar, Puthy Pat, Tetsuyoshi Kariya, Yunosuke Suzuki, Nobuyuki Hamajima, Dearozet Sok, Eiko Yamamoto

Nagoya journal of medical science Vol. 84 ( 3 ) page： 593 - 606 2022.8

Language：English Publishing type：Research paper (scientific journal)

The Center for Child and Adolescent Mental Health (CCAMH) is one of the centers that have psychiatric specialists for children in Cambodia. This study aims to understand the characteristics of children with neuro-developmental disorders, especially autism spectrum disorder (ASD), at CCAMH. This study included 440 cases that were randomly chosen from 2,147 new patients at CCAMH in 2018-2019 and were aged 0-12 years. Socio-demographic factors, parent's information, obstetrical factors, and clinical data were collected from patients' records. A logistic regression analysis and Pearson's chi-square test were used to compare the characteristics between children who were finally diagnosed with ASD and the others (non-ASD). Of the 440 patients, most were male (75.2%), 0-4 years old (57.7%), and diagnosed with ASD (50.0%). Common symptoms were delay of speech, playing alone, and hyperactivity. ASD was significantly more prevalent in male patients compared to females and in the 0-4 years age group compared to the 5-12 years age group. Parents who lived in Phnom Penh and had high education were more likely to visit the CCAMH with their children who were diagnosed with ASD. Regarding treatment, approximately half of all 440 patients had family counselling and psychosocial education. ASD patients had more speech therapy, special education and structured teaching, and networking and coordination therapy compared to non-ASD patients. To provide education and therapy to children with ASD and their parents from the early stage, information about the center and ASD should be widely distributed to all parents in Cambodia.

DOI： 10.18999/nagjms.84.3.593

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Satisfaction With Health Care Services at the Pediatric Specialist Clinic of the National Referral Center in Malaysia: Cross-sectional Study of Caregivers' Perspectives. International journal

Thinakaran M Selvarajah, Eiko Yamamoto, Yu Mon Saw, Tetsuyoshi Kariya, Nobuyuki Hamajima

JMIRx med Vol. 3 ( 2 ) page： e33025 2022.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The concept of customer satisfaction is gaining hold in all corporate sectors worldwide, and a satisfaction survey is used as a tool to discover service problems and as a chance for customers to rate their experience with health care services. A high degree of patient satisfaction with the services given has been found in numerous studies conducted in Malaysian public health care facilities. However, there is limited information available on caregiver satisfaction with pediatric clinics run by the Ministry of Health (MoH) of Malaysia. OBJECTIVE: This was the first research performed at a public hospital's pediatric clinic, which was the first hospital to adopt the public-private-partnership model under the MoH, with the aim of discovering the prevalence and factors affecting the satisfaction of caregivers at the national referral center. METHODS: Cross-sectional research using the standard self-administered SERVQUAL questionnaire was conducted among caregivers accompanying their children to the clinic. The questionnaire consists of 16 paired statements to evaluate their expectations and experiences with the clinic services. RESULTS: A total of 459 caregivers were involved in this study with a majority aged between 30 and 39 years (n=254, 55.4%). Caregivers from the Indian community (adjusted odds ratio [AOR] 2.91, 95% CI 1.37-6.18) and lower income groups (AOR 2.94, 95% CI 1.87-4.64), and those with lower educational backgrounds (AOR 3.58, 95% CI 1.19-10.72) were more likely to be satisfied with the quality of pediatric clinic services. Housewives/househusbands (AOR 0.48, 95% CI 0.25-0.90), on the other hand, appeared less likely to be satisfied with the services provided during their visit to the clinic. Looking at overall patient satisfaction, 50.5% (n=232) of caregivers demonstrated satisfaction with the quality of services, compared to 49.5% (n=227) of dissatisfied respondents. CONCLUSIONS: This paper suggests that, although most caregivers are satisfied with the services, greater emphasis must be placed on delivering reliable service in response to the MoH's mission to provide quality and integrated people-centered health services in Malaysia.

DOI： 10.2196/33025

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Development of a Vietnamese version of the Revised Hasegawa's Dementia scale.

Thi Phuong Tran, Duy Cuong Nguyen, Thi Van Quy Dang, Thi Khuyen Tran, Phong Tuc Vu, Minh Hoang Vu, Thu Hang Le, Thu Nandar Saw, Su Myat Cho, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima, Yu Mon Saw

Nagoya journal of medical science Vol. 84 ( 2 ) page： 402 - 417 2022.5

Language：English Publishing type：Research paper (scientific journal)

As the aging population grows worldwide, the problem of age-related health is becoming an important public health concern. Dementia is a devastating disease that places a significant physical, emotional, and financial burden on patients, their caregivers, and society. It is predicted to increase in developing countries. The Revised Hasegawa's Dementia Scale (HDS-R) has been used in many Asian countries to measure cognitive function. However, there is still no Vietnamese version of the HDS-R. Therefore, this paper describes the development of the HDS-R scale and manual in Vietnamese language. Two Vietnamese researchers translated the HDS-R from English to Vietnamese. To confirm the accuracy of the translation, two other Vietnamese researchers conducted a back-translation. Another pair of Vietnamese researchers compared the back-translated English version to the original one. All six researchers discussed the inconsistencies between English HDS-R scale and manual and derived the most suitable version for the Vietnamese context. In Questions 4 and Question 7, we changed the words from "cherry blossom" and "train" to "daisy flower" and "bicycle" for the first option, and from "plum blossom" to "rose" for the second option. We also changed the expressions in some places in the manual to fit the Vietnamese language. Future studies are needed to validate this version to be able to access cognitive function in both clinical and public healthcare settings.

DOI： 10.18999/nagjms.84.2.402

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Underlying cause of death at medical facilities in Xaiyabouli Province, Lao People's Democratic Republic.

Bounbouly Thanavanh, Singkham Hackpaserd, Souphalak Inthaphatha, Tetsuyoshi Kariya, Yunosuke Suzuki, Eiko Yamamoto, Nobuyuki Hamajima

Nagoya journal of medical science Vol. 84 ( 2 ) page： 448 - 461 2022.5

Language：English Publishing type：Research paper (scientific journal)

In Lao PDR, Ministry of Health introduced District Health Information Software 2 (DHIS2) in 2013. Although DHIS2 includes cause of death, Lao government did not request to report cause of death through DHIS2, resulting in no information on frequency of underlying cause of death even for the deaths at medical facility. This study aimed to collect the information on the underlying cause of death at all medical facilities in Xaiyabouli province, a rural area in Lao PDR. As well as the point estimate of the proportion, a 95% confidence interval (CI) based on a binomial distribution was calculated for each cause of death. According to the local government request, 226 deaths (128 males and 98 females) in 2019 were reported from all medical facilities in the province. Among them, infectious diseases were the most frequent (33.6%, 95% CI 27.5-40.2%); sepsis (16.8%, 95% CI 12.2-22.3%), pneumonia (8.8%, 95% CI 5.5-13.3%), and meningitis (4.9%, 95% CI 2.5-8.5%). Heart diseases were 15.9% (95% CI 11.4-21.4%) including heart failure and myocardial infarction. Injury was 10.2% (95% CI 6.2-14.4%) including brain injury. Neonatal death was 10.6% (95% CI 6.9-15.4%). Among those, preterm death was common (8.8%, 95% CI 5.3-13.3%). Renal failure was 8.0% (95% CI 4.8-12.3%). According to civil registration covering all deaths both at facilities and outside facilities, deaths at facilities were 16.8% of the whole deaths (1,372 deaths) in Xaiyabouli province. Although deaths outside facilities were not included, this is the first report demonstrating cause of death in one province in Lao PDR.

DOI： 10.18999/nagjms.84.2.448

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Rates and Factors Associated With Serious Outcomes of Patient Safety Incidents in Malaysia: An Observational Study. International journal

Khairulina Haireen Khalid, Eiko Yamamoto, Nobuyuki Hamajima, Tetsuyoshi Kariya

Global journal on quality and safety in healthcare Vol. 5 ( 2 ) page： 31 - 38 2022.5

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: This study aimed to examine the reporting rate and the factors associated with serious outcomes of patient safety incidents at public hospitals in Malaysia. METHODS: All patient safety incidents reported in the e-Incident-Reporting System from January to December 2019 were included in the study. A descriptive study was used to describe the characteristics of incidents, and logistic models were used to identify factors associated with low reporting rates and severe harm or death outcomes of incidents. RESULTS: There were 9431 patient safety incidents reported in the system in 2019. The mean reporting rate was 2.1/1000 patient bed-days or 1.5% of hospital admissions. The major category of incidents was drug-related incidents (32.4%). No-harm incidents contributed to 56.1% of all the incidents, while 1.1% resulted in death. More hospitals in the eastern (odds ratio [OR], 12.1) and southern regions (OR, 6.1) had low reporting rates compared to the central region. Incidents with severe harm or death outcomes were associated with more males (OR, 1.4) than females and with the emergency department (OR, 10.6), internal medicine (OR, 5.7), obstetrics and gynecology (OR, 2.4), and surgical department (OR, 5.0) more than the pharmacy department. Compared to drug-related incidents, operation-related (OR, 3.0), procedure-related (OR, 3.5), and therapeutic-related (OR, 4.8) incidents had significantly more severe harm or death outcomes, and patient falls (OR, 0.4) had less severe harm or death outcomes. CONCLUSION: The mean reporting rate was 2.1/1000 patient bed-days or 1.5% of hospital admissions. More hospitals in the eastern and southern regions had low reporting rates. Certain categories of incidents had significantly more severe outcomes.

DOI： 10.36401/JQSH-21-19

PubMed

Patient delay and health system delay of patients with newly diagnosed pulmonary tuberculosis in Mongolia, 2016-2017.

Batmunkh Batbayar, Tetsuyoshi Kariya, Tsolmon Boldoo, Enkhtamir Purevdorj, Naranzul Dambaa, Yu Mon Saw, Eiko Yamamoto, Nobuyuki Hamajima

Nagoya journal of medical science Vol. 84 ( 2 ) page： 339 - 351 2022.5

Language：English Publishing type：Research paper (scientific journal)

Although diagnosis and treatment of tuberculosis (TB) have been improved in many countries, delays in the diagnosis and treatment remain problematic in resource-limited countries. This study aimed to identify factors affecting delays in TB care in Mongolia. Data on TB cases registered from January 2016 to December 2017 were obtained from the national registry of TB at the Department of TB Surveillance and Research in National Center for Communicable Disease. The total number of TB cases registered in these two years was 8,166, including 3,267 cases of newly diagnosed pulmonary TB. Pulmonary TB cases (1,836 males and 1,431 females) were analyzed to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Patient delays longer than the median (28 days) were significantly associated with patient age >32 years (aOR=1.31, 95%CI: 1.14-1.51), residence in areas other than Ulaanbaatar (aimags) (aOR=1.38, 95%CI: 1.20-1.59), and smear-negative (aOR=0.57, 95%CI: 0.47-0.69). Health system delays longer than the median (7 days) were significantly associated with patient age >32 years (aOR=1.16, 95%CI: 1.00-1.33), residence in aimags (aOR=0.82, 95%CI: 0.71-0.95), special facilities including a prison hospital (aOR=4.40, 95%CI: 2.42-7.83), registration in 2017 relative to 2016 (aOR=0.83, 95%CI: 0.71-0.95), and smear-negative (aOR=1.72, 95%CI: 1.42-2.07). Total delays longer than the median (45 days) were significantly associated with patient age >32 years (aOR=1.39, 95%CI: 1.21-1.60), residence in aimags (aOR=1.27, 95%CI: 1.11-1.47), and smear-negative (aOR=0.74, 95%CI: 0.62-0.90). To shorten the total delay, improvement of the access to medical facilities in aimags is necessary.

DOI： 10.18999/nagjms.84.2.339

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Pregnancy Outcomes in Women with Thyroid Diseases

Kotani Tomomi, Imai Kenji, Ushida Takafumi, Moriyama Yoshinori, Nakano-Kobayashi Tomoko, Osuka Satoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Kinoshita Fumie, Hirakawa Akihiro, Iwase Akira, Kikkawa Fumitaka, Kajiyama Hiroaki

JMA Journal Vol. 5 ( 2 ) page： 216 - 223 2022.4

Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Medical Association / The Japanese Associaiton of Medical Sciences

Introduction: Overt hyperthyroidism and hypothyroidism are associated with pregnancy complications; however, most women with these conditions are diagnosed before conception and are under treatment during pregnancy, especially in high-income countries. The purpose of this study was to investigate pregnancy complications among these women.Methods: A retrospective cohort study was conducted, and data on pregnant women who gave birth to a singleton at Nagoya University Hospital in Japan in 2005-2014 was collected. The pregnancy outcomes were divided and compared among three groups: the control group (n = 3531), the hyperthyroidism group (n = 48), and the hypothyroidism group (n = 61). Additionally, risk factors for placental abruption were evaluated by multivariable logistic regression analysis. Moreover, in hyperthyroidism, thyroid function at the placentation period was compared between placental-related diseases and nonplacental-related disease groups, and the latter group included placental abruption and preeclampsia.Results: The incidence of placental abruption was higher in hyperthyroidism than in control and hypothyroidism groups. Hyperthyroidism was independently associated with an increased risk of placental abruption (adjusted odds ratio, aOR = 8.21, 95% confidence interval, CI: 1.76-38.34), as well as preeclampsia (aOR = 4.10, 95% CI: 1.13-14.76) and preterm labor (aOR = 3.38, 95% CI: 1.19-9.64). Additionally, thyroid-stimulating hormone (TSH) at the placentation period was significantly lower in the placental-related disease group than in the nonplacental-related disease group (p < 0.05).Conclusions: Pregnancy outcomes in women with hyperthyroidism and hypothyroidism would be comparable with those without thyroid disease. Hyperthyroidism was an independent risk factor for placental abruption as well as preterm labor and preeclampsia. However, its frequency was extremely low, and further research is required to validate our findings.

DOI： 10.31662/jmaj.2021-0191

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CiNii Research

絨毛癌の免疫微小環境の解明 NK細胞抑制型受容体に着目して

柴田真由, 新美薫, 服部諭美, 西子裕規, 小田結加里, 渡邉絵里, 横井暁, 西野公博, 山本英子, 梶山広明

日本産科婦人科学会雑誌 Vol. 74 ( 臨増 ) page： S - 338 2022.2

絨毛癌MTX耐性株の作成と解析

西子裕規, 新美薫, 横井暁, 吉田康将, 柴田真由, 小田結加里, 渡邉絵里, 西野公博, 山本英子, 梶山広明

日本産科婦人科学会雑誌 Vol. 74 ( 臨増 ) page： S - 512 2022.2

絨毛癌MTX耐性株の作成と解析

西子裕規, 新美薫, 横井暁, 吉田康将, 柴田真由, 小田結加里, 渡邉絵里, 西野公博, 山本英子, 梶山広明

日本産科婦人科学会雑誌 Vol. 74 ( 臨増 ) page： S - 512 2022.2

絨毛癌の免疫微小環境の解明 NK細胞抑制型受容体に着目して

柴田真由, 新美薫, 服部諭美, 西子裕規, 小田結加里, 渡邉絵里, 横井暁, 西野公博, 山本英子, 梶山広明

日本産科婦人科学会雑誌 Vol. 74 ( 臨増 ) page： S - 338 2022.2

Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma. International journal

Kimihiro Nishino, Yuki Nishiko, Mayu Shibata, Yukari Oda, Eri Watanabe, Kaoru Niimi, Eiko Yamamoto, Hiroaki Kajiyama

Placenta Vol. 117 page： 109 - 117 2022.1

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Lysosome-associated membrane glycoprotein 2 (LAMP-2) is a target protein for glycosylation by N-acetylglucosaminyltransferase IV (GnT-IV), which catalyzes the formation of β1,4GlcNAc branches on the mannose core of N-glycans in choriocarcinoma cells. However, the role of LAMP-2, especially when it is expressed in the cell surface membrane of choriocarcinoma cells, has not been well investigated in the progression of choriocarcinoma. This study aimed to elucidate the function of the cell surface membrane LAMP-2 in the malignancy of choriocarcinoma. METHODS: We evaluated the localization of LAMP-2 in some choriocarcinoma cell lines and clinical samples of choriocarcinoma, normal placenta, hydatidiform mole, and invasive mole by flow cytometry, immunocytochemistry, and immunohistochemistry. We performed functional experiments using the knockout or overexpression model of LAMP-2 in the presence or absence of galectins. RESULTS: LAMP-2 was observed in the cell surface membrane of some choriocarcinoma cell lines and tumor cells of choriocarcinoma tissue and trophoblasts of the placenta, hydatidiform mole, and invasive mole. Cell surface membrane LAMP-2 knockout decreased cell adhesion and invasion in choriocarcinoma cells. Conversely, cell surface membrane LAMP-2A overexpression increased cell adhesion and invasion. Experiments in the presence of galectins revealed that abundant N-glycans bound to the peptide core of the luminal side of the cell surface membrane LAMP-2 mediated cell adhesion of choriocarcinoma cells by interacting with galectins in the extracellular matrix (ECM). DISCUSSION: Cell surface membrane LAMP-2, which is glycosylated by GnT-IV, contributes to the malignancy of choriocarcinoma by promoting cell adhesion with the ECM via abundant N-glycans.

DOI： 10.1016/j.placenta.2021.11.005

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Factors associated with severe dengue in Savannakhet Province, Lao People's Democratic Republic.

Phetvilay Senavong, Eiko Yamamoto, Phouvilay Keomoungkhoune, Nouda Prasith, Virasack Somoulay, Tetsuyoshi Kariya, Yu Mon Saw, Tiengkham Pongvongsa, Nobuyuki Hamajima

Nagoya journal of medical science Vol. 83 ( 4 ) page： 749 - 763 2021.11

Language：English Publishing type：Research paper (scientific journal)

This study aimed to describe the socio-demographic and clinical characteristics of dengue inpatients at a provincial hospital, and to identify factors associated with severe dengue. This is a retrospective study involving 402 dengue patients admitted to the Savannakhet Provincial Hospital, Lao People's Democratic Republic (Lao PDR), between January 2018 and April 2019. Socio-demographic factors, clinical signs and laboratory data on admission, final diagnosis, use of health care services before admission, admission date, and hospitalization period were collected from patient records. The number of dengue inpatients was higher in the rainy season than in the dry season. Of the 402 patients, 205 patients (51.0%) were finally diagnosed with severe dengue. Children aged <15 years had more symptoms, higher proportion of severe dengue (69.8% vs. 35.9%), and longer hospitalization (3.5 days vs. 3.0 days) than adults aged ≥15 years. In multivariable analyses, factors associated with severe dengue were nausea on admission (adjusted odds ratio=3.57, 95% CI=1.05-12.09, P=0.04) in children and persistent vomiting on admission (adjusted odds ratio=3.82, 95% CI=1.23-11.92, P=0.02) in adults. In adults, the creatinine level on admission was significantly higher in patients with a final diagnosis of severe dengue compared to the others. The proportion of severe dengue in our study was higher than that in other countries. Nausea and persistent vomiting on admission were suggested to be predictive factors for severe dengue. To reduce the incidence of severe dengue in Lao PDR, improvements in access to health care, referral system, and training of health care workers are needed.

DOI： 10.18999/nagjms.83.4.749

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The current situation of health services for hydatidiform mole in Cambodia. International journal

Eiko Yamamoto, Koum Kanal, Sann Chan Soeung, Noriko Fujita, Sidonn Krang, Puthik Long-Hay, Kimihiro Nishino, Kaoru Niimi, Nobuyuki Hamajima

The journal of obstetrics and gynaecology research Vol. 47 ( 10 ) page： 3652 - 3660 2021.10

Language：English Publishing type：Research paper (scientific journal)

AIM: Management of hydatidiform mole is important to reduce the mortality and morbidity of choriocarcinoma. This study aims to understand the existing health services for hydatidiform mole and to estimate the incidence of gestational trophoblastic disease (GTD) in Cambodia. METHODS: A questionnaire was used to collect information on the existing health services for pregnancy and hydatidiform mole at health facilities from attendants of the 16th Annual Conference of the Cambodian Society of Gynecology and Obstetrics in 2017. The incidence of GTD in 2014-2017 was estimated using Health Information System data. RESULTS: A total of 126 attendants, who were from all provinces except three provinces, answered the questionnaire. The work places were national hospitals (n = 29), provincial hospitals (n = 42), district hospitals (n = 20), health centers (n = 6), and others (n = 29). The answers of participants from the public sector suggested the following: Ultrasonography is available at all hospitals but not health centers; Human chorionic gonadotropin (hCG) measurement is only available at national hospitals; Treatment of hydatidiform mole is performed at national hospitals and provincial hospitals; and Treatment of gestational trophoblastic neoplasia (GTN) is provided at national hospitals. The incidence of hydatidiform mole and GTN at health facilities in the public sector in 2014-2017 was 0.95 per 1000 deliveries and 6.58 per 100 000 deliveries, respectively. CONCLUSIONS: The results suggest that provincial hospitals are important to detect suspected invasive mole and refer to national hospitals for diagnosis and treatment. Further studies on the management of GTD and development of the guidelines of GTD are needed.

DOI： 10.1111/jog.14955

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Short tandem repeat analysis to identify the causative pregnancy of high-risk gestational trophoblastic neoplasia: Molar versus nonmolar pregnancy and its relation to the outcome. International journal

Kimihiro Nishino, Eiko Yamamoto, Yukari Oda, Eri Watanabe, Kaoru Niimi, Toshimichi Yamamoto, Hiroaki Kajiyama

Placenta Vol. 112 page： 28 - 35 2021.9

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Gestational trophoblastic neoplasia (GTN) include a group of malignant neoplasms that originate from the trophoblasts of placental tissue in molar or nonmolar pregnancy. Currently, it is unclear whether the prognosis of high-risk GTN or gestational choriocarcinoma succeeding molar pregnancy or that following a nonmolar one is better. Comparison of the genetic short tandem repeat (STR) patterns of the DNA extracted from the tumor, patient, and her partner allows the genetic origins of the choriocarcinoma to be distinguished - whether it is gestational or non-gestational and whether it is derived from a molar or nonmolar pregnancy in the event it is gestational. This study aimed to investigate the causative pregnancy of patients with high-risk GTN, especially those with poor outcomes, and assess the impact of the causative pregnancy on patient outcome. METHODS: We evaluated 24 patients who were diagnosed with high-risk GTN between January 2000 and October 2019, including 15 cases of pathologically proven gestational choriocarcinomas and the causative pregnancy was investigated by STR analysis in which tumor DNA could be extracted. RESULTS: In high-risk GTN without history of anteceding molar pregnancies, nonmolar pregnancy was the causative pregnancy, which was confirmed in three cases. Molar pregnancy appeared be the causative pregnancy of high-risk GTN in patients with a history of antecedent molar pregnancies either with or without interruption by subsequent nonmolar pregnancies prior to developing high-risk GTN. High-risk GTN in most of the evaluated deceased cases (three of four) was due to nonmolar pregnancy, while all but one case with molar pregnancy as the causative pregnancy survived. DISCUSSION: STR analysis can distinguish the causative pregnancy of high-risk GTN, and nonmolar pregnancy as the causative pregnancy might have negative effects on the outcome of the disease.

DOI： 10.1016/j.placenta.2021.06.015

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Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity. International journal

Kenichi Nakamura, Kaoru Niimi, Eiko Yamamoto, Yoshiki Ikeda, Kimihiro Nishino, Shiro Suzuki, Hiroaki Kajiyama, Fumitaka Kikkawa

Biochemistry and biophysics reports Vol. 26 page： 100951 - 100951 2021.7

Language：English Publishing type：Research paper (scientific journal)

Hyperglycosylated human chorionic gonadotropin (H-hCG) is secreted from choriocarcinoma and contains a core2 O-glycan formed by core2 β1,6-N-acetylglucosaminyl transferase (C2GnT). Choriocarcinoma is considered immunogenic as it is gestational and contains paternal chromosomal components. Here we examined the function of C2GnT in the evasion of choriocarcinoma cells from natural killer (NK) cell-mediating killing. We determined that C2GnT is highly expressed in malignant gestational trophoblastic neoplasms. C2GnT KO downregulates core2 O-glycan expression in choriocarcinoma cells, which are more efficiently killed by NK cells than control cells. C2GnT KO cell containing tumor necrosis factor-related apoptosis inducing ligand have lower viability than control cells. Additionally, poly-N-acetyllactosamine in core2 branched oligosaccharides on MHC class I-related chain A (MICA) and mucin1 (MUC1) is significantly reduced in C2GnT KO cells. Meanwhile, the cumulative survival rate of nude mice inoculated with C2GnT KO tumors was higher than that of the control group. These findings suggest that choriocarcinoma cells may escape NK cell-mediated killing via glycosylation of MICA and MUC1.

DOI： 10.1016/j.bbrep.2021.100951

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Next-generation genome sequencing of a matched normal-tumor pair from a patient with intractable gestational choriocarcinoma: A case report. International journal

Kaoru Niimi, Eiko Yamamoto, Sachi Morita, Maki Morikawa, Hikaru Hattori, Miki Hatakeyama, Mami Morita, Kimihiro Nishino, Yukari Oda, Eri Watanabe, Toshimichi Yamamoto, Hiroaki Kajiyama, Fumitaka Kikkawa

Molecular and clinical oncology Vol. 15 ( 1 ) page： 143 - 143 2021.7

Language：English Publishing type：Research paper (scientific journal)

Gestational choriocarcinoma is a gestational trophoblastic neoplasia (GTN) originating from trophoblastic cells with abnormal proliferation. Although chemotherapy is effective for treating this cancer, when patients develop chemoresistance, personalized treatment, such as the use of drugs matching their genomes, is required. The present report describes a case of intractable gestational choriocarcinoma identified using a next-generation sequencing (NGS)-based tumor panel. A 51-year-old woman was diagnosed with gestational choriocarcinoma via pathological and short tandem repeat analyses. The patient did not achieve remission despite many regimens of chemotherapy, including high-dose therapy with autologous peripheral blood stem cell transplantation. To identify drugs tailored to this particular choriocarcinoma, NGS was performed on the tumor of the patient, and the tumor genome was compared with that of the patient's blood sample using the NCC Oncopanel System. Consequently, 245 single nucleotide variants (SNVs) with a mean SNV allele frequency of 63.1% were identified. This high frequency was because the genome of the gestational choriocarcinoma contained part of the genome of the partner. Therefore, our experience of the present intractable case of choriocarcinoma suggested that matched normal-tumor pair analysis is not appropriate for treatment decisions in GTN cases. When using an NGS-based tumor panel to assess choriocarcinoma, researchers must consider whether the genomic DNA of the patient and their partner are involved in the GTN.

DOI： 10.3892/mco.2021.2305

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Assessment of myocardial performance index in late-onset fetal growth restriction.

Tran Thao Nguyen Nguyen, Tomomi Kotani, Kenji Imai, Takafumi Ushida, Yoshinori Moriyama, Tomoko Kobayashi, Kaoru Niimi, Seiji Sumigama, Eiko Yamamoto, Van Duc Vo, Minh Tam Le, Lam Huong Le, Dac Nguyen Nguyen, Vu Quoc Huy Nguyen, Quang Vinh Truong, Ngoc Thanh Cao, Fumitaka Kikkawa

Nagoya journal of medical science Vol. 83 ( 2 ) page： 259 - 268 2021.5

Language：English Publishing type：Research paper (scientific journal)

The aim of this study is to determine whether the myocardial performance index (MPI) is increased in fetal growth restriction (FGR) fetuses and if increased MPI is related to adverse outcomes of FGR. This is a prospective cross-sectional study. Seventy-three late-onset FGR fetuses and 97 gestational-age matched control fetuses were enrolled in this study. Fetal blood flow parameters including MPI values were measured and compared between the two groups. For the effect of severity of growth restriction on MPI value, they were also compared with < 3rd and 3rd - 10th centile groups. FGR fetuses were divided into two groups by favorable and adverse outcome and ultrasound parameters were compared between these two groups. Moreover, significant factors related to adverse outcomes by univariate analysis were analyzed by multivariate logistic regression analysis. Pulsatility index of umbilical arterial flow (UA-PI), MPI and amniotic fluid index in the FGR were significantly different from the control fetuses. However, no significant difference between < 3rd and 3rd - 10th centile groups was detected in MPI and UA-PI. The increased levels of MPI and UA-PI were independently related with adverse outcome of late-onset FGR pregnancy. In conclusion, MPI values were increased in late-onset FGR pregnancy, and the higher level of MPI could predict adverse outcome as well as the measurement of UA-PI. Clinicians should consider cardiac dysfunction in FGR through increased MPI.

DOI： 10.18999/nagjms.83.2.259

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A poor prognostic metastatic nongestational choriocarcinoma of the ovary: a case report and the literature review. International journal

Kimihiro Nishino, Eiko Yamamoto, Yoshiki Ikeda, Kaoru Niimi, Toshimichi Yamamoto, Hiroaki Kajiyama

Journal of ovarian research Vol. 14 ( 1 ) page： 56 - 56 2021.4

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Pure ovarian choriocarcinoma can be gestational or nongestational in origin. Nongestational pure ovarian choriocarcinoma is extremely rare and the prognosis is thought to be worse than that of the gestational type in patients with metastatic disease. We present a case of metastatic pure ovarian choriocarcinoma with poor prognosis in which the origin was identified as nongestational by DNA short tandem repeat (STR) analysis. CASE PRESENTATION: A nulliparous woman in her thirties with metastatic choriocarcinoma was referred to our hospital after initial treatment proved unsuccessful. Two months earlier, she had undergone brain tumor resection and histological examination confirmed choriocarcinoma. Serum human chorionic gonadotropin (hCG) concentration at initial diagnosis was 5030 IU/L. Two cycles of a combination chemotherapy regimen of methotrexate, etoposide, and actinomycin-D (MEA therapy), which is commonly used for gestational choriocarcinoma, was administered. However, the disease could not be controlled. Imaging modalities at presentation revealed tumor present in the left ovary and left lung, but not in the uterus, which led us think that the choriocarcinoma was nongestational. Bleomycin, etoposide, and cisplatin (BEP therapy) which is commonly used for nongestational choriocarcinoma (malignant germ cell tumor) and surgical resection of the uterus, bilateral ovaries, and an affected part of the left lung led to the nadir level of hCG, but the tumor relapsed and levels of hCG again increased. To investigate the origin of choriocarcinoma, we performed DNA STR analysis of tumor cells and oral mucosal cells. Analysis revealed the origin of the choriocarcinoma as nongestational, as the genotype of tumor cells entirely corresponded with that of oral mucosal cells. BEP therapy and chemotherapy regimens administered for nongestational choriocarcinoma and gestational choriocarcinoma proved ineffective, and the patient died 21 months after diagnosis of metastatic choriocarcinoma. CONCLUSION: Metastaic nongestational pure choriocarcinoma of ovary is an extremely rare and an aggressive disease, frequently resulting in poor outcome.

DOI： 10.1186/s13048-021-00810-3

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妊娠24週で高度貧血によりterminationとなるも生児を得た胎児共存奇胎の一例

渡邉絵里, 新美薫, 牛田貴文, 小田結加里, 西野公博, 小谷友美, 山本英子, 梶山広明

日本産科婦人科学会雑誌 Vol. 73 ( 臨増 ) page： S - 576 2021.3

Factors associated with neonatal mortality in a tertiary hospital in Phnom Penh, Cambodia Reviewed International coauthorship

Leak P, Yamamoto E, Noy P, Keo D, Krang S, Kariya T, Saw YM, Siek M, Hamajima N.

Nagoya Jouranl of Medical Science Vol. 83 ( 1 ) page： 113 - 124 2021.2

Rate of achievement of therapeutic outcomes and factors associated with control of non-communicable diseases in rural east Malaysia: implications for policy and practice Reviewed International coauthorship

Keng ZY, Saw YM, Thung SC, Chong WW, Albert A, Kariya T, Yamamoto E, Hamajima N.

Scientific Reports Vol. 11 ( 1 ) page： 3812 - 3812 2021.2

Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity Reviewed

Nakamura K, Niimi K, Yamamoto E, Ikeda Y, Nishino K, Suzuki S, Kajiyama H, Kikkawa F.

Biochem Biophys Rep . Vol. 26 page： 100951 - 100951 2021.2

Factors associated with neonatal mortality in a tertiary hospital in Phnom Penh, Cambodia.

Ponloeu Leak, Eiko Yamamoto, Pisey Noy, Dane Keo, Sidonn Krang, Tetsuyoshi Kariya, Yu Mon Saw, Meng Siek, Nobuyuki Hamajima

Nagoya journal of medical science Vol. 83 ( 1 ) page： 113 - 124 2021.2

Language：English Publishing type：Research paper (scientific journal)

This study aimed to identify hospital neonatal mortality rate (NMR) and the causes of neonatal deaths, and to understand risk factors associated with neonatal mortality in a national tertiary hospital in Cambodia. The study included all newborn infants, aged 0-28 days old, hospitalized in the Pediatrics department of Khmer-Soviet Friendship Hospital between January 2016 and December 2017. In total, 925 infants were included in the study. The mean gestational age was 35.9 weeks (range, 24-42 weeks). Preterm infants and low birth weight accounted for 47.5% and 56.7%, respectively. With respect to payment methods, the government (53.5%) and non-governmental organizations (NGO) (13.7%) paid the fees as the families were not in a financial position to do so. The hospital NMR at the Pediatrics department was 9.3%. Respiratory distress syndrome (37.2%) was the main cause of deaths followed by hypoxic-ischemic encephalopathy (31.4%) and neonatal infection (21.0%). Factors associated with neonatal mortality were Apgar score at 5th minute <7 (adjusted odds ratio (AOR) = 3.57), payment by the government or NGO (AOR = 11.32), admission due to respiratory distress (AOR = 11.94), and hypothermia on admission (AOR = 9.41). The hospital NMR in the Pediatrics department was 9.3% (95% confidence interval 7.50-11.35) at Khmer-Soviet Friendship Hospital; prematurity and respiratory distress syndrome were the major causes of neonatal mortality. Introducing continuous positive airway pressure machine for respiratory distress syndrome and creating neonatal resuscitation guidelines and preventing hypothermia in delivery rooms are required to reduce the high NMR.

DOI： 10.18999/nagjms.83.1.113

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Assessment of nutritional status and risk factors for malnutrition among the elderly in Loikaw, Myanmar Reviewed International coauthorship

May Thet Nu Noe, Yu Mon Saw, Thu Nandar Saw, Yoon Pwint Kyaw, Poe Ei Zin, Su Myat Cho, Tetsuyoshi Kariya, Eiko Yamamoto, Hla Hla Win, Tin Wann, Nobuyuki Hamajima

Nutrition Vol. 79-80 page： 110933 - 110933 2020.11

Assessment of quality of life among elderly in urban and peri-urban areas, Yangon Region, Myanmar. Reviewed International coauthorship International journal

Poe Ei Zin, Yu Mon Saw, Thu Nandar Saw, Su Myat Cho, Su Su Hlaing, May Thet Nu Noe, Tetsuyoshi Kariya, Eiko Yamamoto, Kay Thi Lwin, Hla Hla Win, Nobuyuki Hamajima

PloS one Vol. 15 ( 10 ) page： e0241211 2020.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: In the context of an aging population, quality of life (QOL) is an important consideration for the well-being of the elderly. However, there is limited information on the QOL of the elderly in Myanmar. This study aimed to explore the risk factors for low QOL among the elderly in urban and peri-urban areas of the Yangon Region, Myanmar. METHODS: A community-based, cross-sectional study was conducted among the elderly aged 60 years or older in two urban and two peri-urban townships in the Yangon Region from July to September 2019. A multi-stage sampling method was used to recruit study participants using a pre-tested questionnaire. A total of 616 (305 males and 311 females) elderly people were interviewed using a face-to-face interview technique. Multiple linear regression analysis was performed on the four domains (physical health, psychological health, social relationship, and environment) of QOL measured with the WHOQOL-BREF. RESULTS: Income level and having intimate friends influenced the QOL scores of the elderly in all domains, while education level and marital status influenced psychological health, social relationship, and environment domains. Social interaction with neighbors increased the QOL scores for physical health, social relationship, and environment domains. Living in peri-urban areas was associated with lower QOL scores for physical health, psychological health, and environment, while participation in group activities increased QOL scores in these domains. Having comorbidities affected the QOL for psychological health and environment domains, while the frequency of going out affected physical health, and the frequency of religious performance affected social relationship. CONCLUSION: Residential location, education level, marital status, income, comorbidities, social interactions with neighbors and friends, participation in group activities, and frequencies of going out and religious activities should be considered in planning and implementing programs for the elderly in Myanmar. Peri-urban development, strengthening healthcare and social security systems, and encouraging social interaction and participation in group activities play critical roles in improving the QOL for elderly residing in Myanmar.

DOI： 10.1371/journal.pone.0241211

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Geographic distribution and utilisation of CT and MRI services at public hospitals in Myanmar. Reviewed International coauthorship International journal

Moe Khaing, Yu Mon Saw, Thet Mon Than, Aye Myat Mon, Su Myat Cho, Thu Nandar Saw, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

BMC health services research Vol. 20 ( 1 ) page： 742 - 742 2020.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Diagnosis by computed tomography (CT) and magnetic resonance imaging (MRI) is important for patient care. However, the geographic distribution and utilisation of these machines in countries with limited resources, such as Myanmar, have not been sufficiently studied. Therefore, this study aims to identify the geographic distribution and utilisation of CT and MRI services at public hospitals in Myanmar. METHODS: This nationwide, cross-sectional study was conducted at 43 public hospitals in Myanmar. Data were collected retrospectively using a prepared form from 1st January 2015 to 31st December 2017 at public hospitals in Myanmar. A descriptive analysis was performed to calculate the number of CT and MRI units per million population in each state and region of Myanmar. The distribution of CT and MRI units was assessed using the Lorenz curve and Gini coefficient, which are indicators of inequality in distribution. RESULTS: In total, 45 CT and 14 MRI units had been installed in public hospitals in Myanmar by 2017. In total, 205,570 CT examinations and 18,981 MRI examinations have been performed within the study period. CT units per million population in 2017 varied from 0.30 in Rakhine State to 3.22 in Kayah State. However, MRI units were available only in public hospitals in five states/regions. The Gini coefficient for CT and MRI was 0.35 and 0.69, respectively. An upward trend in the utilisation rate of CT and MRI was also observed during the study period, especially among patients aged between 36 and 65 years. CONCLUSIONS: Throughout Myanmar, CT units were more equally distributed than MRI units. CT and MRI units were mostly concentrated in the Yangon and Mandalay Regions, where the population density is higher. The geographic distribution and utilisation rate of CT and MRI units varied among states, regions, and patients' age group. However, the utilisation rates of CT and MRI increased annually in all states and regions during the review period. The Ministry of Health and Sports in Myanmar should consider the utilisation and population coverage of CT and MRI as an important factor when there will be procurement of those medical equipment in the future.

DOI： 10.1186/s12913-020-05610-x

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Determinants of diarrhea in children under the age of five in Afghanistan: a secondary analysis of the Afghanistan Demographic and Health Survey 2015. Reviewed International coauthorship

Ahmad Nasir Wasiq, Yu Mon Saw, Sultani Jawid, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

Nagoya journal of medical science Vol. 82 ( 3 ) page： 545 - 556 2020.8

Language：English Publishing type：Research paper (scientific journal)

Diarrhea is the second leading cause of under-five mortality and globally accounts for 526,000 child deaths every year. Afghanistan, with 33,000 child deaths in 2012, was ranked 8th among nations, with the highest under-five deaths being from pneumonia and diarrhea. This study aimed to identify the determinants of diarrhea in children under the age of five in Afghanistan. A secondary data analysis of the Afghanistan Demographic and Health Survey (AfDHS) 2015 was focused on diarrhea in children under the age of five. The dataset of the AfDHS 2015 was used for the analysis. The subjects for this study were 30,238 under-five children. A logistic regression model was applied to examine the determinants of childhood diarrhea. This study found that 7,921 (26.2%) out of 30,238 under-five children had diarrhea within the two weeks preceding the survey. Higher maternal education accompanied a lower risk of childhood diarrhea with an adjusted odds ratio (AOR) of 0.70 (P<0.01) than did no education. Flush toilets (AOR=0.84, P<0.01) and traditional dry vaults (AOR=0.83, P<0.001) were less likely associated with diarrhea compared with pit latrines. Tube wells, public taps, and unprotected wells and springs were sources of drinking water with a higher risk of diarrhea than piped water. This study identified that the type of toilet facility, source of drinking water, age of the child, and maternal education were important determinants of under-five diarrhea. Intervention programs concerning improved sanitation facilities, sources of drinking water, and raising women's level of education and health awareness are important.

DOI： 10.18999/nagjms.82.3.545

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Estimation of the unvaccinated among those aged less than 25 years according to aimag and its association with incidence of measles outbreak 2015-2016 in Mongolia. Reviewed International coauthorship

Enkhbold Sereenen, Yu Mon Saw, Ryenchindorj Erkhembayar, Baigal Volodya, Otgonbayar Dashpagma, Oyunchimeg Orsoo, Tetsuyoshi Kariya, Chimedsuren Ochir, Eiko Yamamoto, Nobuyuki Hamajima

Nagoya journal of medical science Vol. 82 ( 3 ) page： 437 - 447 2020.8

Language：English Publishing type：Research paper (scientific journal)

Mongolia had an epidemic of measles in 2015-2016, even though more than 90% of the population have been vaccinated since 1997. This study aimed to examine the associations between unvaccinated proportion and measles incidence according to aimag. Mongolia has 21 provinces (aimag) with Ulaanbaatar as the capital city. Vaccination coverage between 1991 and 2014 and measles incidence according to aimag were obtained from the National Center for Communicable Diseases of Mongolia database. Accumulated unvaccinated proportion (AUP) among those aged 1 to 24 years in 2015 was estimated from the unvaccinated at the 1st dose of 1991 to 2014. From 1991 to 2014, unvaccinated proportion among those aged 1 to 24 years in the whole country has been reducing from 28.0% in 1991 to 1.8% in 2014. The AUP in 2015 varied from 2.7% (Selenge) to 21.8% (Govisumber). The incidence was remarkably higher in only two aimags with a large density of the unvaccinated aged 1 to 24 years (Ulaanbaatar and Darkhan-Uul) than in the other aimags. The incidence had no significant correlation with the AUP, although the correlation between the incidence and the density of unvaccinated aged 1 to 24 years was significant when the two aimags were included. In conclusion, the AUP between 2.7% and 21.8% had no correlation with the incidence according to aimags in Mongolia measles epidemic 2015-2016.

DOI： 10.18999/nagjms.82.3.437

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Etiologic agents of acute diarrhea in sentinel surveillance sites in Vientiane Capital, Lao People's Democratic Republic, 2012-2015. Reviewed International coauthorship International journal

Souphatsone Houattongkham, Eiko Yamamoto, Noikaseumsy Sithivong, Souphalak Inthaphatha, Tetsuyoshi Kariya, Yu Mon Saw, Arounnapha Vongduangchanh, Onechanh Keosavanh, Nobuyuki Hamajima

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Vol. 39 ( 6 ) page： 1115 - 1122 2020.6

Language：English Publishing type：Research paper (scientific journal)

This study aims to identify the pathogens of diarrhea in Vientiane Capital, Lao People's Democratic Republic (Lao PDR). The data of 2482 patients who visited eight health facilities due to diarrhea in 2012-2015 were retrospectively reviewed. Stool or rectal swabs collected from all patients were tested for bacteria. Children who were under 5 years old were additionally tested for rotavirus. Of 2482 cases, 1566 cases were under 5 years old, and at least one enteropathogen was detected in 475 cases (19.1%). Salmonella species was the most commonly detected bacterial pathogen. Enteropathogenic Escherichia coli (EPEC) and Salmonella species was the major pathogen in the dry season and the wet season, respectively. Eighty-seven patients tested positive for multiple bacteria. Rotavirus was detected in 291 children under 5 years old (32.4%), mostly from October to April. The major bacteria of coinfection with rotavirus were EPEC followed by Salmonella species. Salmonella species was the predominant bacterial pathogen of diarrhea of all ages, and rotavirus was the predominant pathogen among children under 5 years old. Further studies examining other types of pathogens for diarrhea and the introduction of a rotavirus vaccine for children are needed in Lao PDR.

DOI： 10.1007/s10096-020-03827-6

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Evaluation of a routine second curettage for hydatidiform mole: a cohort study. Reviewed

Eiko Yamamoto, Kimihiro Nishino, Kaoru Niimi, Eri Watanabe, Yukari Oda, Kazuhiko Ino, Fumitaka Kikkawa

International journal of clinical oncology Vol. 25 ( 6 ) page： 1178 - 1186 2020.6

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The aim of this study was to evaluate routine second curettage for hydatidiform mole (HM) by comparing the characteristics and outcomes of developing gestational trophoblastic neoplasia (GTN). STUDY DESIGN: This was a cohort study including 173 patients diagnosed with HM between January 2002 and August 2019 who were followed up at Nagoya University Hospital, Japan. After an evacuation, 105 and 68 patients were managed with the routine method (routine group) and elective method (elective group) for a second curettage, respectively. The routine second curettage was performed around 7 days after the first evacuation. Patients in the elective group underwent a second curettage if there was ultrasonographic evidence of molar remnants in the uterine cavity. Socio-clinical factors were retrospectively compared between the routine and elective groups, and between patients showing regression and those who developed GTN. RESULTS: The incidence of GTN was 15.2% in the routine group and 20.6% in the elective group, and the difference was not significant (P = 0.364). The median GTN risk score was significantly higher in the routine group than in the elective group (P = 0.033). Presence of a complete HM, gestational age, and a pre-treatment human chorionic gonadotropin level of ≥ 200,000 mIU/mL were independent risk factors for GTN in molar patients. CONCLUSION: The incidence of GTN was unchanged but the risk score of GTN was higher in the routine group than in the elective group. Routine second curettage may not be necessary, but further study will be needed to confirm this.

DOI： 10.1007/s10147-020-01640-x

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Prevalence of alcohol consumption and its risk factors among university students: A cross-sectional study across six universities in Myanmar. Reviewed International coauthorship International journal

Hein Htet, Yu Mon Saw, Thu Nandar Saw, Nang Mie Mie Htun, Khaing Lay Mon, Su Myat Cho, Thinzar Thike, Aye Thazin Khine, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

PloS one Vol. 15 ( 2 ) page： e0229329 2020.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Globally, alcohol consumption is a significant public health concern and it is one of the most important risk behaviours among university students. Alcohol consumption can lead to poor academic performance, injuries, fights, use of other substances, and risky sexual behaviours among students. However, the study explored the prevalence of alcohol consumption and the associated risk factors among university students since these have not been fully examined in previous research. Therefore, the aim of this study was to explore the prevalence of alcohol consumption and the associated risk factors among university students in Myanmar. METHODS: The present cross-sectional study was conducted using a sample of 15-24-year-old university students who were selected from six universities in Mandalay, Myanmar, in August 2018. In total, 3,456 students (males: 1,301 and females: 2,155) were recruited and asked to respond to a self-administered questionnaire. Multiple logistic regression analysis was used to estimate the adjusted odds ratio (AOR) and 95% confidence interval (CI) for alcohol consumption among university students. RESULTS: The prevalence of alcohol consumption in the previous 30 days was 20.3% (males: 36.0%, females: 10.8%). The alcohol consumption was significantly higher among males (AOR = 2.3, 95% CI; 1.9-2.9), truant students (AOR = 2.1, 95% CI; 1.3-3.3), smokers (AOR = 7.0, 95% CI; 5.1-9.7), students who reported feeling of hopelessness or sadness (AOR = 1.4, 95% CI; 1.2-1.8), peers' alcohol consumption (AOR = 7.5, 95% CI; 4.8-11.7). CONCLUSION: The present study revealed that males, smokers, peer alcohol consumption, and truant students had higher odds of alcohol consumption among the students. Therefore, effective campus-based counselling, peer education, and national surveillance systems that can monitor risky drinking behaviours among university students should be implemented. Further, government regulations that control the production, sale, promotion, advertising, and restriction of alcohol should be well developed and strengthened, as in the case of other Southeast Asian countries.

DOI： 10.1371/journal.pone.0229329

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Association between body mass index and ready-to-eat food consumption among sedentary staff in Nay Pyi Taw union territory, Myanmar. Reviewed International coauthorship International journal

Thin Zar Thike, Yu Mon Saw, Htin Lin, Khin Chit, Aung Ba Tun, Hein Htet, Su Myat Cho, Aye Thazin Khine, Thu Nandar Saw, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

BMC public health Vol. 20 ( 1 ) page： 206 - 206 2020.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Ready-to-eat (RTE) food consumption has become popular in the working community with the increase in full-time jobs and the limited time to prepare food. Although RTE food is essential for this community, its consumption causes obesity. In Myanmar, obesity is a modifiable risk factor for non-communicable diseases, causing increases in morbidity and mortality. This study aimed to identify the association between body mass index (BMI) and RTE food consumption among sedentary staff in Nay Pyi Taw Union Territory, Myanmar. METHODS: A cross-sectional study was conducted in 2018, in which 400 respondents participated in face-to-face interviews. The study area was selected using simple random sampling and drawing method. Measuring tape and digital weighing scale were used to measure the height and weight of the respondents. BMI was calculated by dividing the weight by height squared (kg/m2). Overweight and obesity were categorized by World Health Organization cut-off points. The collected data were analyzed using multiple logistic regression to estimate the adjusted odds ratio (AOR), and the 95% confidence interval (CI). RESULTS: This study revealed that sedentary staff who consumed RTE food once or more per month were nearly five times more likely to be overweight and obese (AOR = 4.78, 95% CI 1.44-15.85) than those who consumed RTE food less frequently. In addition, five factors namely being older than 32 years (AOR = 3.97, 95% CI 1.82-8.69), preference for RTE food (AOR = 8.93, 95% CI 2.54-31.37), light-intensity of physical exercise (AOR = 3.55, 95% CI 1.63-7.73), sedentary leisure activities (AOR = 3.32, 95% CI 1.22-9.03), and smoking (AOR = 5.62, 95% CI 1.06-29.90) were positively associated with overweight and obesity. CONCLUSION: Frequent consumers of RTE food and less physically active sedentary staff were more likely to be overweight and obese. This study highlights the urgent need to raise awareness regarding healthy lifestyle behaviors among the working community to reduce the burden of obesity-related chronic diseases. Moreover, sedentary workers should be aware of the food-based dietary guidelines of the country. Policy makers should strictly enforce nutritional labeling of RTE food, and strictly prohibit over-branding of RTE food.

DOI： 10.1186/s12889-020-8308-6

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Cross-sectional study on tobacco advertising, promotion and sponsorship (TAPS) and violations of tobacco sale regulations in Myanmar: do these factors affect current tobacco use among Myanmar high school students? Reviewed International coauthorship International journal

Su Myat Cho, Yu Mon Saw, Nyi Nyi Latt, Thu Nandar Saw, Hein Htet, Moe Khaing, Thet Mon Than, Ei Mon Win, Zaw Zaw Aung, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

BMJ open Vol. 10 ( 2 ) page： e031933 2020.2

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: To examine the associations of current tobacco use with tobacco advertising, promotion and sponsorship (TAPS), and illicit tobacco sales exposures among Myanmar high school students. DESIGN: A quantitative, cross-sectional study. SETTING: Seven high schools from both urban and rural areas of four states and regions in Myanmar. PARTICIPANTS: In total, 1174 high school students (482 males and 692 females) were interviewed using a self-administered questionnaire. MAIN OUTCOME MEASURE: Current tobacco use of participants, defined as using any kind of smoked or smokeless tobacco product at least one occasion within the past 30 days. RESULTS: The prevalence of TAPS exposure was 90.9% among high school students in Myanmar. Current tobacco use was positively associated with being over 14 years old (adjusted OR (AOR) 9.81; 95% CI 4.54 to 21.19), being male (AOR 28.06; 95% CI 13.29 to 59.25), exposure to any kind of TAPS (AOR 6.59; 95% CI 2.33 to 18.64), having seen any smoked tobacco product for sale inside or within 100 feet of the school premises (AOR 4.17; 95% CI 1.65 to 10.58), having seen the sale or gifting of any smoked tobacco product to minors (AOR 6.46; 95% CI 2.18 to 19.12) and having seen the sale or distribution of any smoked tobacco product by minors (AOR 2.42; 95% CI 1.42 to 4.10). Having ever received health education about tobacco use (AOR 0.45; 95% CI 0.27 to 0.78), or having a higher perception score of tobacco use (AOR 0.17; 95% CI 0.10 to 0.30) were negatively associated with current tobacco use. CONCLUSIONS: There was an alarming prevalence of TAPS exposure among Myanmar high school students. TAPS exposure and violations of tobacco sale regulations were strong risk factors for current tobacco use among Myanmar high school students, while health education about tobacco products was reported as an effective protective factor. Specific smokeless tobacco sale regulations for minors are needed immediately in Myanmar.

DOI： 10.1136/bmjopen-2019-031933

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Disease frequency among inpatients at a tertiary general hospital in Lao PDR. Reviewed International coauthorship

Viengsakhone Louangpradith, Bounfeng Phoummalaysith, Tetsuyoshi Kariya, Yu Mon Saw, Eiko Yamamoto, Nobuyuki Hamajima

Nagoya journal of medical science Vol. 82 ( 1 ) page： 113 - 121 2020.2

Language：English Publishing type：Research paper (scientific journal)

In Lao People's Democratic Republic (Lao PDR), reports on disease frequency are very limited. This study aimed to report frequencies of the main cause of admission among inpatients of a tertiary general hospital (Mittaphab Hospital) in Vientiane. Subjects were inpatients who were admitted from January 3 to February 2 in 2017. The dataset were made as a pilot run to establish hospital statistics. The data on sex, age, address (province), dates of admission and discharge, and main diagnosis were collected from paper-based medical charts. International Classification of Diseases 10 was applied for classifying the main diagnosis. During the 1-month period, 1,201 inpatients (637 males and 564 females) were admitted, including 171 (14.2%) aged <20 years and 254 (21.1%) aged ≥60 years. About 20% patients were from outside of Vientiane. Among them, 67.5% (62.5% in males and 73.8% in females) were admitted within 7 days. The main causes with more than 10% in males were injury and poisoning S00-T98 (49.8%), while those in females were injury and poisoning S00-T98 (25.2%), pregnancy and childbirth O00-O99 (19.0%), and diseases of genitourinary system N00-N99 (13.7%). Injury and poisoning S00-T98 among inpatients aged <20 years was 81.8% in males and 59.0% in females. Among those aged 20-59 years, it was 49.9% and 22.4%, and among those aged ≥60 years it was 22.3% and 16.9%, respectively. This is the first report on the frequencies of main diseases among inpatients in Lao PDR. Injury was the first main cause of admission at the tertiary hospital.

DOI： 10.18999/nagjms.82.1.113

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Estimating cost of hospitalization for childbirth at a tertiary hospital in Mongolia. Reviewed International coauthorship

Bolorchimeg Taazan, Eiko Yamamoto, Bayart Baatar, Avirmed Amgalanbaatar, Tetsuyoshi Kariya, Yu Mon Saw, Nobuyuki Hamajima

Nagoya journal of medical science Vol. 82 ( 1 ) page： 47 - 57 2020.2

Language：English Publishing type：Research paper (scientific journal)

Health services for pregnancy and delivery at public health facilities are fully subsidized by the government in Mongolia. However, it has been reported that health financing, budget planning, and implementation processes are weak. Therefore, this study aims to estimate the costs per inpatient of vaginal delivery and cesarean section (C-section) by using data gathered from a tertiary hospital in Ulaanbaatar. Inpatient and financial data were collected from the Statistics and Finance, Economics Department of National Center for Maternal and Child Health. A top-down method was used for the calculation of unit costs. The total number of deliveries in 2016 were 11,033, including 7,777 vaginal deliveries and 3,256 C-sections. The cost per inpatient stay for vaginal delivery and C-section were USD 255 and USD 592, respectively. The average cost per bed-day of the six departments of the obstetrics and gynecology hospital was USD 80. The percentage that represents employees' salary in the cost per inpatient was as low as 12.4% for vaginal delivery and 18.5% for C-section, although the cost for salaries accounted for 51.2% of the total expenditure of the hospital. Results show that the cost per inpatient of C-section was two times higher than that of vaginal delivery. The cost of childbirths may account for approximately 9% of total health expenditure of the country. These results may be advantageous to the government in instituting a policy and controlling the health care budget to improve cost-effectiveness and equal access to all in health care services in Mongolia.

DOI： 10.18999/nagjms.82.1.47

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Assessing risk factors and impact of cyberbullying victimization among university students in Myanmar: A cross-sectional study. Reviewed International coauthorship International journal

Aye Thazin Khine, Yu Mon Saw, Zaw Ye Htut, Cho Thet Khaing, Htin Zaw Soe, Kyu Kyu Swe, Thinzar Thike, Hein Htet, Thu Nandar Saw, Su Myat Cho, Tetsuyoshi Kariya, Eiko Yamamoto, Nobuyuki Hamajima

PloS one Vol. 15 ( 1 ) page： e0227051 2020.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Cyberbullying is a global public health concern with tremendous negative impacts, not only on the physical and mental health of students but also on their well-being and academic performance. However, there are very few studies on cyberbullying among university students, especially in Myanmar. This study aims to determine the percentage of university students who suffered cyberbullying victimization in the last 12 months, and the association between students' socio-demographic characteristics, adverse events following cyberbullying and cyberbullying victimization. METHODS: A cross-sectional study was conducted among university students aged 18 years and older at one medical university in Magway, Myanmar. A total of 412 students (277 males and 135 females) participated in the study. Data were collected from August to September, 2018 using a self-administered questionnaire. Multiple logistic regression analyses (models I and II) were performed to estimate the unadjusted (UOR) and adjusted odds ratios (AOR), and 95% confidence intervals (CI). RESULTS: In total, 40.8% of males and 51.1% of females in the study had suffered cyberbullying victimization in the past 12 months. In model I, students who had been studying at the university for 3 years or less (AOR = 1.81; 95% CI 1.14-2.85), and who had witnessed psychological, physical or sexual violence, or cyberbullying in their neighborhoods, (AOR = 2.95; 95% CI 1.48-5.91) were more likely to have suffered cyberbullying victimization in the past 12 months. In model II, being a victim of cyberbullying was associated with difficulties in concentrating and understanding lectures (AOR = 3.96; 95% CI 1.72-9.11), and substance abuse (AOR = 2.37; 95% CI 1.02-5.49). Non-resident students were at a higher risk of being cyberbullying victims than their resident peers (AOR = 1.86; 95% CI 1.04-3.34). CONCLUSION: Two out of five students had suffered cyberbullying victimization in the past 12 months, and only half of the victims discussed their experience(s) with someone else. Students who suffered cyberbullying victimization faced academic difficulties and started or increased smoking, betel chewing or alcohol drinking. Counter measures to prevent and mitigate the adverse events related to cyberbullying victimization are urgently needed among university students in Myanmar. Periodic screening for cyberbullying, counseling services, cyber-safety educational programs, and awareness raising campaigns should be implemented.

DOI： 10.1371/journal.pone.0227051

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Dengue fever during pregnancy

Trinh Tien Dat, Kotani Tomomi, Yamamoto Eiko, Shibata Kiyosumi, Moriyama Yoshinori, Tsuda Hiroyuki, Yamashita Mamoru, Kajiyama Hiroaki, Dien Duc Thien Minh, Le Quang Thanh, Kikkawa Fumitaka

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 2 ) page： 241 - 247 2018.5

Establishment and characterization of cell lines derived from complete hydatidiform mole. Reviewed

Yamamoto E, Niimi K, Kiyono T, Yamamoto T, Nishino K, Nakamura K, Kotani T, Kajiyama H, Shibata K, Kikkawa F

International Journal of Molecular Medicine Vol. 40 ( 3 ) page： 614-622 2017.9

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Gestational trophoblastic diseases (GTDs) are a group of diseases characterized by abnormal cellular proliferation of atypical trophoblasts. A hydatidiform mole is an abnormal pregnancy caused by genetic fertilization disorders, and it can be classified as a complete hydatidiform mole (CHM) or a partial hydatidiform mole. The aim of this study was to establish cell lines from CHMs and to characterize the cells for future studies concerning GTD. HMol1-2C, HMol1-3B, HMol1-8 and HMol3-1B were established from primary cultures of CHM explants following the introduction of different combinations of genes including human telomerase reverse transcriptase (hTERT), a mutant form of CDK (CDK4R24C), cyclin D1, p53C234, MYC and HRAS. HMol1-2C, HMol1-3B, and HMol3-1B were confirmed to originate from trophoblasts of androgenic, homozygous CHMs. These three cell lines exhibited low human chorionic gonadotropin secretion, low migration and invasion abilities, and the potential to differentiate into syncytiotrophoblastic cells via forskolin treatment. These results suggest that these cells exhibit characteristics of trophoblastic cells, especially cytotrophoblastic cells. HMol1-8 was found to consist of diploid cells and originated from maternal cells, suggesting that they were derived from decidual cells. In conclusion, we successfully established three cell lines from CHMs by introduction of hTERT and other genes. Analysis revealed that the genetic origin of each cell line was identical with that of the original molar tissue, and the cell lines exhibited characteristics of trophoblastic cells, which are similar to undifferentiated cytotrophoblasts.

DOI： 10.3892/ijmm.2017.3067.

Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells. Reviewed

Sakata J, Utsumi F, Suzuki S, Niimi K, Yamamoto E, Shibata K, Senga T, Kikkawa F, Kajiyama H.

Oncotarget Vol. 8 ( 59 ) page： 99482-99494 2017.8

Spontaneous regression of gestational trophoblastic neoplasia. Reviewed

Niimi K, Yamamoto E, Nishino K, Fujiwara S, Ino K, Kikkawa F.

Gynecolgic Oncology Reports Vol. 25 ( 21 ) page： 98-100 2017.7

N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma. Reviewed

Nishino K, Yamamoto E, Niimi K, Sekiya Y, Yamashita Y, Kikkawa F.

Oncology reports Vol. 38 ( 1 ) page： 440-448 2017.7

c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling. Reviewed

Sekiya Y, Yamamoto E, Niimi K, Nishino K, Nakamura K, Kotani T, Kajiyama H, Shibata K, Kikkawa F.

Oncology Vol. 92 ( 5 ) page： 299-310 2017.3

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE:
Choriocarcinoma is the most common epithelial cancer among gestational trophoblastic diseases (GTDs); the mechanism of trophoblastic carcinogenesis is unknown. This study aimed to examine the expression of NF-κB family proteins in GTDs and placental tissues as well as the roles of c-Rel in choriocarcinoma.
METHODS:
We examined the expression of NF-κB family proteins in normal placenta and hydatidiform mole tissues as well as extravillous trophoblast (EVT) and choriocarcinoma cell lines by Western blot and immunohistochemistry. Immunoprecipitation was performed to determine which proteins can bind with c-Rel in choriocarcinoma cells. To investigate the roles of c-Rel in choriocarcinoma, we examined the effects of c-Rel knockdown and overexpression on cell proliferation, migration, and invasion using small interfering RNAs and gene activation plasmid.
RESULTS:
The expression of c-Rel was strong in choriocarcinoma and EVTs, but very weak in villi of normal placenta and hydatidiform mole. Immunoprecipitation suggested that c-Rel heterodimerizes with p65 in choriocarcinoma. c-Rel knockdown reduced invasion, migration, and AKT phosphorylation in choriocarcinoma cells. c-Rel overexpression in choriocarcinoma increased migratory and invasive abilities, and the effect on invasion was inhibited by a PI3K inhibitor.
CONCLUSION:
These findings suggest that c-Rel might play a role in promoting the invasion of choriocarcinoma cells through PI3K/AKT signaling.

DOI： 10.1159/000458529.

High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review. Reviewed

Yamamoto E, Niimi K, Fujikake K, Nishida T, Murata M, Mitsuma A, Ando Y, Kikkawa F.

Molecular and Clinical Oncology Vol. 5 ( 5 ) page： 660-664 2016.11

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Choriocarcinoma is a malignant gestational trophoblastic neoplasia (GTN) and one of the curable types of gynecological cancer. However, 10% of choriocarcinoma patients have a poor prognosis, particularly when they have metastasis, apart from pulmonary metastasis, or do not go into remission by the second chemotherapeutic regimen. We herein present the case of a 36-year-old patient who had choriocarcinoma with metastases to the lungs, liver and kidneys. The 5th and 6th regimens with cisplatin for choriocarcinoma failed and the patient developed brain metastases. She was then treated with four cycles of high-dose ifosfamide, carboplatin and etoposide (ICE) with blood progenitor cell support after confirming the effectiveness of ICE at normal doses. The serum human chorionic gonadotropin (hCG) level was 140,009 mIU/ml at the start of high-dose ICE and the patient tolerated this regimen well. However, the beneficial effect was decreasing with each successive course of treatment, with the lowest level of hCG at 103 mIU/ml after the fourth course. The patient did not achieve complete remission and succumbed to the disease 4 months after the last chemotherapy. The findings of the present case and a review of the related literature suggest that high-dose ICE with stem cell rescue may be considered as a viable treatment option for a multi-drug resistant choriocarcinoma or GTN.

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. Reviewed

Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y, Wang J, Miki R, Yamamoto E, Iwase A, Bando YK, Hirayama M, Ohno K, Toyokuni S, Kikkawa F.

Free Radic Biol Med. Vol. 101 page： 524-533 2016.11

Gestational Trophoblastic Neoplasia and Pregnancy Outcome After Routine Second Curettage for Hydatidiform Mole: A Retrospective Observational Study Reviewed

Momo Kan, M.D., Eiko Yamamoto, M.D., Ph.D., Kaoru Niimi, M.D., Ph.D., Koji Tamakoshi, M.D., Ph.D., Yoko Sekiya, M.D., Kimihiro Nishino, M.D., Kazuhiko Ino, M.D., Ph.D., and Fumitaka Kikkawa, M.D., Ph.D.

Journal of Reproductive Medicine Vol. 61 ( 4 ) page： 373-379 2016.8

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To investigate gestational trophoblastic neoplasia (GTN), fertility, and pregnancy outcome in molar patients who underwent routine second curettage.
STUDY DESIGN: Eighty-two patients who visited our hospital for hydatidiform mole between 2002 and 2011 were registered in this study. All patients had second curettage around the 7th day after first evacuation. We performed retrospective analysis on several factors between a remission group and a GTN group.

RESULTS: Fourteen patients (17.1%) had chemotherapy after being diagnosed with GTN. Multivariate analysis revealed that the hCG value before first evacuation was only one independent prognostic factor for GTN. The median follow-up period was 45.5 months, and 41 patients had 62 pregnancies after remission of hydatidiform mole and GTN. The fertility rate was 80% in 45 patients with desire for a baby, and 39 pregnancies (62.9%) ended in live births without congenital malformation.

CONCLUSION: The incidence of GTN was not lower in hydatidiform mole with routine second curettage. An independent prognostic factor for GTN was the hCG value before the first evacuation in molar patients. Our results suggest that routine second curettage does not affect the fertility rate or increase a risk of adverse outcomes in subsequent pregnancies.

Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation Reviewed

Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, Niimi K, Sakaguchi Y, Nagasaka T, Takahashi T, Shibata K, Kajiyama H, Kikkawa F, Toyokuni S.

Int J Cancer Vol. 135 ( 2 ) page： 305 2014.7

Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells. Reviewed

Niimi K, Murakumo Y, Watanabe N, Kato T, Mii S, Enomoto A, Asai M, Asai N, Yamamoto E, Kajiyama H, Shibata K, Kikkawa F, Takahashi M.

Cancer Sci. Vol. 105 ( 5 ) page： 545-52 2014.5

Identification of causative pregnancy of gestational trophoblastic neoplasia diagnosed during pregnancy by short tandem repeat analysis. Reviewed

Yamamoto E, Niimi K, Shinjo K, Yamamoto T, Fukunaga M, Kikkawa F.

Gynecol Oncol Case Rep. Vol. 9 page： 3-6 2014.4

High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma Reviewed

Niimi K, Yamamoto E, Fujiwara S, Shinjo K, Kotani T, Umezu T, Kajiyama H, Shibata K, Ino K, Kikkawa F

Br J Cancer Vol. 107 ( 12 ) page： 1969-1977 2012.12

無心体の一例 Reviewed

山本英子, 石川智則, 渡辺真夕, 蛭川純子, 湯原均, 阿部史朗, 猪俣吉廣, 宇野雅哉, 稲坂織恵, 宮坂尚幸

日本産科婦人科学会関東連合地方部会会報 ( 3 ) page： 347 2000.8

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