論文 - 山本　英子

High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review. 査読有り

Yamamoto E, Niimi K, Fujikake K, Nishida T, Murata M, Mitsuma A, Ando Y, Kikkawa F.

Molecular and Clinical Oncology   5 巻 ( 5 ) 頁： 660-664   2016年11月

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Choriocarcinoma is a malignant gestational trophoblastic neoplasia (GTN) and one of the curable types of gynecological cancer. However, 10% of choriocarcinoma patients have a poor prognosis, particularly when they have metastasis, apart from pulmonary metastasis, or do not go into remission by the second chemotherapeutic regimen. We herein present the case of a 36-year-old patient who had choriocarcinoma with metastases to the lungs, liver and kidneys. The 5th and 6th regimens with cisplatin for choriocarcinoma failed and the patient developed brain metastases. She was then treated with four cycles of high-dose ifosfamide, carboplatin and etoposide (ICE) with blood progenitor cell support after confirming the effectiveness of ICE at normal doses. The serum human chorionic gonadotropin (hCG) level was 140,009 mIU/ml at the start of high-dose ICE and the patient tolerated this regimen well. However, the beneficial effect was decreasing with each successive course of treatment, with the lowest level of hCG at 103 mIU/ml after the fourth course. The patient did not achieve complete remission and succumbed to the disease 4 months after the last chemotherapy. The findings of the present case and a review of the related literature suggest that high-dose ICE with stem cell rescue may be considered as a viable treatment option for a multi-drug resistant choriocarcinoma or GTN.

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. 査読有り

Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y, Wang J, Miki R, Yamamoto E, Iwase A, Bando YK, Hirayama M, Ohno K, Toyokuni S, Kikkawa F.

Free Radic Biol Med.   101 巻   頁： 524-533   2016年11月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.freeradbiomed.2016.10.491.

Gestational Trophoblastic Neoplasia and Pregnancy Outcome After Routine Second Curettage for Hydatidiform Mole: A Retrospective Observational Study 査読有り

Momo Kan, M.D., Eiko Yamamoto, M.D., Ph.D., Kaoru Niimi, M.D., Ph.D., Koji Tamakoshi, M.D., Ph.D., Yoko Sekiya, M.D., Kimihiro Nishino, M.D., Kazuhiko Ino, M.D., Ph.D., and Fumitaka Kikkawa, M.D., Ph.D.

Journal of Reproductive Medicine   61 巻 ( 4 ) 頁： 373-379   2016年8月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVE: To investigate gestational trophoblastic neoplasia (GTN), fertility, and pregnancy outcome in molar patients who underwent routine second curettage.
STUDY DESIGN: Eighty-two patients who visited our hospital for hydatidiform mole between 2002 and 2011 were registered in this study. All patients had second curettage around the 7th day after first evacuation. We performed retrospective analysis on several factors between a remission group and a GTN group.

RESULTS: Fourteen patients (17.1%) had chemotherapy after being diagnosed with GTN. Multivariate analysis revealed that the hCG value before first evacuation was only one independent prognostic factor for GTN. The median follow-up period was 45.5 months, and 41 patients had 62 pregnancies after remission of hydatidiform mole and GTN. The fertility rate was 80% in 45 patients with desire for a baby, and 39 pregnancies (62.9%) ended in live births without congenital malformation.

CONCLUSION: The incidence of GTN was not lower in hydatidiform mole with routine second curettage. An independent prognostic factor for GTN was the hCG value before the first evacuation in molar patients. Our results suggest that routine second curettage does not affect the fertility rate or increase a risk of adverse outcomes in subsequent pregnancies.

Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation 査読有り

Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, Niimi K, Sakaguchi Y, Nagasaka T, Takahashi T, Shibata K, Kajiyama H, Kikkawa F, Toyokuni S.

Int J Cancer   135 巻 ( 2 ) 頁： 305   2014年7月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Suppression of REV7 enhances cisplatin sensitivity in ovarian clear cell carcinoma cells. 査読有り

Niimi K, Murakumo Y, Watanabe N, Kato T, Mii S, Enomoto A, Asai M, Asai N, Yamamoto E, Kajiyama H, Shibata K, Kikkawa F, Takahashi M.

Cancer Sci.   105 巻 ( 5 ) 頁： 545-52   2014年5月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Identification of causative pregnancy of gestational trophoblastic neoplasia diagnosed during pregnancy by short tandem repeat analysis. 査読有り

Yamamoto E, Niimi K, Shinjo K, Yamamoto T, Fukunaga M, Kikkawa F.

Gynecol Oncol Case Rep.   9 巻   頁： 3-6   2014年4月

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma 査読有り

Niimi K, Yamamoto E, Fujiwara S, Shinjo K, Kotani T, Umezu T, Kajiyama H, Shibata K, Ino K, Kikkawa F

Br J Cancer   107 巻 ( 12 ) 頁： 1969-1977   2012年12月

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

無心体の一例 査読有り

山本 英子, 石川 智則, 渡辺 真夕, 蛭川 純子, 湯原 均, 阿部 史朗, 猪俣 吉廣, 宇野 雅哉, 稲坂 織恵, 宮坂 尚幸

日本産科婦人科学会関東連合地方部会会報   ( 3 ) 頁： 347   2000年8月

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担当区分：筆頭著者   記述言語：日本語   掲載種別：研究論文（学術雑誌）