2022/04/06 更新

写真a

イシガミ マサトシ
石上 雅敏
ISHIGAMI, Masatoshi
所属
大学院医学系研究科 総合医学専攻 病態内科学 准教授
大学院担当
大学院医学系研究科
学部担当
医学部 医学科
職名
准教授
連絡先
メールアドレス

学位 1

  1. 医学博士 ( 1999年9月   名古屋大学 ) 

研究キーワード 3

  1. 肝移植

  2. 肝不全

  3. 肝疾患

研究分野 1

  1. その他 / その他  / 消化器内科学

現在の研究課題とSDGs 1

  1. 肝不全における病態肝移植後患者における病態肝疾患患者における病態

学歴 1

  1. 名古屋大学   医学部

    1985年4月 - 1991年3月

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    国名: 日本国

所属学協会 5

  1. 日本内科学会

  2. 日本消化器病学会   学会評議員

  3. 日本肝臓学会   学会評議員

  4. 日本移植学会

  5. 日本再生医療学会

 

論文 165

  1. Frequent incidence of escape mutants after successful hepatitis B vaccine response and stopping of nucleos(t)ide analogues in liver transplant recipients. 査読有り

    Ishigami M1, Honda T, Ishizu Y, Onishi Y, Kamei H, Hayashi K, Ogura Y, Hirooka Y, Goto H.

    Liver Transpl   20 巻 ( 10 ) 頁: 1211-1220   2014年10月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  2. Different effect of HBV vaccine after liver transplantation between chronic HBV carriers and non-HBV patients who received HBc-Ab positive grafts. 査読有り

    Ishigami M, Kamei H, Nakamura T, Katano Y, Ando H, Kiuchi T, Goto H

    J Gastroenterol   46 巻   頁: 367-377   2011年3月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  3. Change of strategies and future perspectives against hepatitis B recurrence after liver transplantation 招待有り 査読有り

    Ishigami M, Ogura Y, Hirooka Y, Goto H.

    World J Gastroenterol   21 巻 ( 36 ) 頁: 10290-10298   2015年9月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3748/wjg.v21.i36.10290.

  4. Anti-hepatitis B surface immunoglobulin reduction in early postoperative period after liver transplantation in hepatitis B virus-positive patients 査読有り

    Ishigami M, Onishi Y, Ito T, Katano Y, Itoh A, Hirooka Y, Kiuchi T, Goto H.

    Hepatol Res.   41 巻   頁: 1189-1198   2011年12月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  5. *Use of the Model for End-Stage Liver Disease (MELD) score to predict 1-year survival of Japanese patients with cirrhosis and to determine who will benefit from living donor liver transplantation.

    Ishigami M, Honda T, Okumura A, Ishikawa T, Kobayashi M, Katano Y, Fujimoto Y, Kiuchi T, Goto H.

    J Gastroenterol   43 巻   頁: 363-368   2008年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  6. Impact of recipient age and preoperative fasting blood glucose level as the risk factors of living donor liver transplantation in cirrhotic patients in the recent comprehensive era with knowledge of indications-recent status in a Japanese single center. 査読有り

    Ishigami M, Onishi Y, Kamei H, Kiuchi T, Katano Y, Itoh A, Hirooka Y, Goto H

    Hepatol Res   43 巻   頁: 1148-1155   2013年11月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  7. Long-term dynamics of hematological data and spleen volume in cirrhotic patients after liver transplantation-various dynamics depending on etiology. 査読有り

    Ishigami M, Ishizu Y, Onishi Y, Kamei H, Kiuchi T, Itoh A, Hirooka Y, Katano Y, Goto H

    Springerplus   2 巻   頁: 374   2013年8月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  8. Impact of early elevation of serum bilirubin during treatment with pegylated interferon and ribavirin in patients with chronic hepatitis C. 査読有り

    Ishigami M, Hayashi K, Katano Y, Itoh A, Hirooka Y, Goto H.

    Hepatol Res   40 巻   頁: 963-970   2010年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  9. Risk factors of recipient receving living donor liver transplantation in the comprehensive era of indication and perioperative managements. 査読有り

    Ishigami M, Katano Y, Hayashi K, Ito A, Hirooka Y, Onishi Y, Nakamura T, Kiuchi T, Goto H.

    Nagoya J Med Sci   72 巻   頁: 119-127   2010年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  10. *Two cases of central venous catheter-related thrombosis in living liver donors: how can the risk be minimized?

      23 巻   頁: 289-293   2009年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  11. *Mutations in carboxy-terminal part of E2 including PKR/eIF2 alpha phosphorylation homology domain and interferon sensitivity determining region of nonstructural 5A of hepatitis C virus 1b: Their correlation with response to interferon monotherapy and viral load.

    Ukai K, Ishigami M, Yoshioka K, Kawabe N, Katano Y, Hayashi K, Honda T, Yano M, Goto H

    World J Gastroenterol   23 巻   頁: 3722-3728   2006年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  12. Differences in the intestinal microbiome associated with diarrhea during lenvatinib treatment for hepatocellular carcinoma.

    Inukai Y, Yamamoto K, Honda T, Ito T, Imai N, Ishizu Y, Nakamura M, Kawashima H, Ishigami M

    Digestive diseases (Basel, Switzerland)     2022年3月

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    記述言語:英語  

    DOI: 10.1159/000524298

    PubMed

  13. Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline

    Iwama Shintaro, Kobayashi Tomoko, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Ando Masahiko, Zhou Xin, Yamagami Ayana, Onoue Takeshi, Kawaguchi Yohei, Miyata Takashi, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Wakahara Keiko, Yokota Kenji, Kato Masashi, Nishio Naoki, Tanaka Chie, Miyata Kazushi, Ogura Atsushi, Ito Takanori, Sawada Tsunaki, Shimokata Tomoya, Niimi Kaoru, Ohka Fumiharu, Ishigami Masatoshi, Gotoh Momokazu, Hashimoto Naozumi, Saito Ryuta, Kiyoi Hitoshi, Kajiyama Hiroaki, Ando Yuichi, Hibi Hideharu, Sone Michihiko, Akiyama Masashi, Kodera Yasuhiro, Arima Hiroshi

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   107 巻 ( 4 ) 頁: E1620 - E1630   2022年3月

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    記述言語:日本語  

    DOI: 10.1210/clinem/dgab829

    Web of Science

    PubMed

  14. Long-Term Efficacy and Safety of Rifaximin in Japanese Patients with Hepatic Encephalopathy: A Multicenter Retrospective Study.

    Kawaratani H, Kondo Y, Tatsumi R, Kawabe N, Tanabe N, Sakamaki A, Okumoto K, Uchida Y, Endo K, Kawaguchi T, Oikawa T, Ishizu Y, Hige S, Takami T, Terai S, Ueno Y, Mochida S, Takikawa Y, Torimura T, Matsuura T, Ishigami M, Koike K, Yoshiji H

    Journal of clinical medicine   11 巻 ( 6 )   2022年3月

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    記述言語:英語  

    DOI: 10.3390/jcm11061571

    PubMed

  15. Patients with low muscle mass have characteristic microbiome with low potential for amino acid synthesis in chronic liver disease.

    Yamamoto K, Ishizu Y, Honda T, Ito T, Imai N, Nakamura M, Kawashima H, Kitaura Y, Ishigami M, Fujishiro M

    Scientific reports   12 巻 ( 1 ) 頁: 3674   2022年3月

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    記述言語:英語  

    DOI: 10.1038/s41598-022-07810-3

    PubMed

  16. Changes in the gut microbiome in relation to the degree of gastric mucosal atrophy before and after Helicobacter pylori eradication

    Furune Satoshi, Yamamoto Kenta, Honda Takashi, Fujiyoshi Toshihisa, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Nakamura Masanao, Miyahara Ryoji, Kawashima Hiroki, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   57 巻 ( 3 ) 頁: 266 - 273   2022年3月

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  17. Changes in Body Composition Predict the Time to Treatment Failure of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma: A Pilot Retrospective Study

    Yamamoto Takafumi, Imai Norihiro, Kuzuya Teiji, Yokoyama Shinya, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishigami Masatoshi

    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL     頁: 1 - 10   2022年3月

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  18. Fecal incontinence and oral regurgitation during duodenal endoscopic submucosal dissection using the water pressure method

    Takada Yoshihisa, Hirose Takashi, Nishida Kazuki, Kakushima Naomi, Furukawa Kazuhiro, Furune Satoshi, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY   34 巻 ( 3 ) 頁: 526 - 534   2022年3月

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    記述言語:日本語  

    DOI: 10.1111/den.14070

    Web of Science

    PubMed

  19. The impact of the age-adjusted Charlson comorbidity index as a prognostic factor for endoscopic papillectomy in ampullary tumors

    Takada Yoshihisa, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Ito Akihiro, Hirooka Yoshiki

    JOURNAL OF GASTROENTEROLOGY   57 巻 ( 3 ) 頁: 199 - 207   2022年3月

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  20. Artificial intelligence-based diagnosis of upper gastrointestinal subepithelial lesions on endoscopic ultrasonography images

    Hirai Keiko, Kuwahara Takamichi, Furukawa Kazuhiro, Kakushima Naomi, Furune Satoshi, Yamamoto Hideko, Marukawa Takahiro, Asai Hiromitsu, Matsui Kenichi, Sasaki Yoji, Sakai Daisuke, Yamada Koji, Nishikawa Takahiro, Hayashi Daijuro, Obayashi Tomohiko, Komiyama Takuma, Ishikawa Eri, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Ishikawa Takuya, Ohno Eizaburo, Nakamura Masanao, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    GASTRIC CANCER   25 巻 ( 2 ) 頁: 382 - 391   2022年3月

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  21. Preliminary Comparison of Endoscopic Brush and Net Catheters as the Sampling Tool to Analyze the Intestinal Mucus in the Rectum with Ulcerative Colitis Patients

    Nakamura Masanao, Maeda Keiko, Yamamoto Kenta, Yamamura Takeshi, Sawada Tsunaki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Iida Tadashi, Mizutani Yasuyuki, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki

    DIGESTION     頁: 1 - 12   2022年2月

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    記述言語:日本語  

    DOI: 10.1159/000521929

    Web of Science

    PubMed

  22. Immunoproliferative Small Intestinal Disease Diagnosed by Double-balloon Endoscopy with Biopsy Sampling.

    Meza MRR, Nakamura M, Yamamura T, Maeda K, Sawada T, Ishikawa E, Kakushima N, Furukawa K, Ohno E, Honda T, Kawashima H, Ishigami M

    Internal medicine (Tokyo, Japan)     2022年2月

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    記述言語:英語  

    DOI: 10.2169/internalmedicine.8847-21

    PubMed

  23. Immune-related Liver Injury is a Poor Prognostic Factor in Patients with Nonsmall Cell Lung Cancer Treated with Immune Checkpoint Inhibitors

    Yamamoto Takafumi, Ito Takanori, Hase Tetsunari, Ishigami Masatoshi, Mizuno Kazuyuki, Yamamoto Kenta, Imai Norihiro, Ishizu Yoji, Honda Takashi, Shibata Hirofumi, Hatta Takahiro, Yogo Naoyuki, Yasuda Satoshi, Toyoda Hidenori, Abe Takashi, Kawashima Hiroki, Hashimoto Naozumi, Fujishiro Mitsuhiro

    CANCER INVESTIGATION   40 巻 ( 2 ) 頁: 189 - 198   2022年2月

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  24. Renal Outcomes With Tenofovir Alafenamide in Liver Transplant Recipients.

    Liu JK, Vutien P, Huang DQ, Ishigami M, Landis CS, Nguyen MH, REAL-B Liver Transplant Study Group.

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     2022年2月

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    記述言語:英語  

    DOI: 10.1016/j.cgh.2022.01.035

    PubMed

  25. Factors related to delayed adverse events of endoscopic submucosal dissection in the duodenum.

    Kawamura T, Hirose T, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Honda T, Ishigami M, Kawashima H, Fujishiro M

    Digestive diseases (Basel, Switzerland)     2022年2月

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    記述言語:英語  

    DOI: 10.1159/000522362

    PubMed

  26. Absence of large portal collateral vessels is associated with spontaneous improvement of cirrhotic portal vein thrombosis

    Yokoyama Shinya, Ishizu Yoji, Honda Takashi, Imai Norihiro, Ito Takanori, Yamamoto Kenta, Tsuzuki Tomoyuki, Ishigami Masatoshi

    HEPATOLOGY RESEARCH   52 巻 ( 2 ) 頁: 199 - 209   2022年2月

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    記述言語:日本語  

    DOI: 10.1111/hepr.13725

    Web of Science

    PubMed

  27. Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitis

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   84 巻 ( 1 ) 頁: 169 - 179   2022年2月

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    記述言語:日本語  

    DOI: 10.18999/nagjms.84.1.169

    Web of Science

  28. Comparison of outcomes between secondary fully covered and uncovered self-expandable metal stents in the treatment of recurrent biliary obstruction of pancreatic cancer

    Kataoka Kunio, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Mizutani Yasuyuki, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES     2022年1月

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  29. Evaluation of ulcerative colitis activity using transabdominal ultrasound shear wave elastography

    Yamada Kenta, Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Iida Tadashi, Ishikawa Eri, Mizutani Yasuyuki, Sawada Tsunaki, Maeda Keiko, Yamamura Takeshi, Kakushima Naomi, Furukawa Kazuhiro, Nakamura Masanao, Ishigami Masatoshi, Fujishiro Mitsuhiro

    QUANTITATIVE IMAGING IN MEDICINE AND SURGERY   12 巻 ( 1 ) 頁: 618 - 626   2022年1月

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    記述言語:日本語  

    DOI: 10.21037/qims-21-403

    Web of Science

    PubMed

  30. Differentiation Between Solid Pseudopapillary Neoplasm of the Pancreas and Nonfunctional Pancreatic Neuroendocrine Neoplasm Using Endoscopic Ultrasound

    Kataoka Kunio, Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    PANCREAS   51 巻 ( 1 ) 頁: 106 - 111   2022年1月

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  31. Feasibility of endoscopic ultrasonography using a 60-MHz ultrasound miniature probe in the upper gastrointestinal tract

    Asai Hiromitsu, Furukawa Kazuhiro, Miyahara Ryoji, Funasaka Kohei, Furune Satoshi, Nakamura Masanao, Kawashima Hiroki, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    JOURNAL OF MEDICAL ULTRASONICS   49 巻 ( 1 ) 頁: 61 - 69   2022年1月

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  32. Fish bone migration after pancreaticoduodenectomy: Incidence and treatment options

    Takada Yoshihisa, Ishikawa Takuya, Kawashima Hiroki, Mizutani Yasuyuki, Ohno Eisaburo, Iida Tadashi, Ogawa Hiroshi, Hayashi Masamichi, Takami Hideki, Onoe Shunsuke, Ishigami Masatoshi

    JOURNAL OF DIGESTIVE DISEASES   23 巻 ( 1 ) 頁: 44 - 49   2022年1月

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    記述言語:日本語  

    DOI: 10.1111/1751-2980.13077

    Web of Science

    PubMed

  33. The influence of hepatitis C virus eradication on hepatocarcinogenesis in patients with hemophilia HCC after HCV eradication in hemophilia

    Inukai Yosuke, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    ANNALS OF HEPATOLOGY   27 巻 ( 1 ) 頁: 100545   2022年

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  34. Indications and Limitations Associated with the Patency Capsule Prior to Capsule Endoscopy

    Nakamura Masanao, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    INTERNAL MEDICINE   61 巻 ( 1 ) 頁: 5 - 13   2022年

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  35. Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching

    Saito Masashi, Yamamura Takeshi, Nakamura Masanao, Maeda Keiko, Sawada Tsunaki, Ishikawa Eri, Mizutani Yasuyuki, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   27 巻 ( 47 ) 頁: 8182 - 8193   2021年12月

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  36. Changes in the gut microbiota after hepatitis C virus eradication

    Honda Takashi, Ishigami Masatoshi, Yamamoto Kenta, Takeyama Tomoaki, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Nakamura Masanao, Kawashima Hiroki, Miyahara Ryoji, Ishikawa Tetsuya, Hirooka Yoshiki, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   11 巻 ( 1 ) 頁: 23568   2021年12月

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  37. Obesity and myosteatosis: the two characteristics of dynapenia in patients with cirrhosis

    Sugiyama Yoshiaki, Ishizu Yoji, Ando Yusuke, Yokoyama Shinya, Yamamoto Kenta, Ito Takanori, Imai Norihiro, Nakamura Masanao, Honda Takashi, Kawashima Hiroki, Ishikawa Tetsuya, Ishigami Masatoshi

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY   33 巻 ( 1S Suppl 1 ) 頁: E916 - E921   2021年12月

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  38. Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival

    Yamada Kentaro, Sawada Tsunaki, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Ishikawa Eri, Iida Tadashi, Mizutani Yasuyuki, Kakushima Naomi, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Furune Satoshi, Hase Tetsunari, Yokota Kenji, Maeda Osamu, Hashimoto Naozumi, Akiyama Masashi, Ando Yuichi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   27 巻 ( 41 ) 頁: 7190 - 7206   2021年11月

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  39. Safety and Efficacy of Glass Membrane Pumping Emulsification Device in Transarterial Chemoembolization for Hepatocellular Carcinoma: First Clinical Outcomes

    Imai Norihiro, Yokoyama Shinya, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishigami Masatoshi

    ANTICANCER RESEARCH   41 巻 ( 11 ) 頁: 5817 - 5820   2021年11月

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  40. Microbiome, fibrosis and tumor networks in a non-alcoholic steatohepatitis model of a choline-deficient high-fat diet using diethylnitrosamine

    Yamamoto Kenta, Honda Takashi, Yokoyama Shinya, Ma Lingyun, Kato Asuka, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Nakamura Masanao, Kawashima Hiroki, Ishigami Masatoshi, Tsuji Noriko M., Fujishiro Mitsuhiro

    DIGESTIVE AND LIVER DISEASE   53 巻 ( 11 ) 頁: 1443 - 1450   2021年11月

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  41. Differentiation between pancreatic metastases from renal cell carcinoma and pancreatic neuroendocrine neoplasm using endoscopic ultrasound

    Kataoka Kunio, Ishikawa Takuya, Ohno Eizaburo, Mizutani Yasuyuki, Iida Tadashi, Ishikawa Eri, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    PANCREATOLOGY   21 巻 ( 7 ) 頁: 1364 - 1370   2021年10月

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  42. Clinical course of liver injury induced by immune checkpoint inhibitors in patients with advanced malignancies

    Ito Takanori, Ishigami Masatoshi, Yamamoto Takafumi, Mizuno Kazuyuki, Yamamoto Kenta, Imai Norihiro, Ishizu Yoji, Honda Takashi, Kawashima Hiroki, Yasuda Satoshi, Toyoda Hidenori, Yokota Kenji, Hase Tetsunari, Nishio Naoki, Maeda Osamu, Kato Masashi, Hashimoto Naozumi, Hibi Hideharu, Kodera Yasuhiro, Sone Michihiko, Ando Yuichi, Akiyama Masashi, Shimoyama Yoshie, Fujishiro Mitsuhiro

    HEPATOLOGY INTERNATIONAL   15 巻 ( 5 ) 頁: 1278 - 1287   2021年10月

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  43. Factors associated with bleeding after endoscopic variceal ligation in children

    Yokoyama Shinya, Ishizu Yoji, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ito Takanori, Hinoki Akinari, Sumida Wataru, Shirota Chiyoe, Tainaka Takahisa, Makita Satoshi, Yokota Kazuki, Uchida Hiroo, Fujishiro Mitsuhiro

    PEDIATRICS INTERNATIONAL   63 巻 ( 10 ) 頁: 1223 - 1229   2021年10月

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    記述言語:日本語  

    DOI: 10.1111/ped.14614

    Web of Science

    PubMed

  44. RENAL OUTCOMES IN POST-LIVER TRANSPLANT RECIPIENTS TREATED WITH TENOFOVIR ALAFENAMIDE COMPARED WITH TENOFOVIR DISOPROXIL FUMARATE AND ENTECAVIR

    Liu Joanne, Vutien Philip, Huang Daniel, Ishigami Masatoshi, Daniel Peter Chen Yang Nikhil, Ito Takanori, Dang Hansen, Maeda Mayumi, Leong Jennifer, Landis Charles, Nguyen Mindie H.

    HEPATOLOGY   74 巻   頁: 492A - 493A   2021年10月

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    記述言語:日本語  

    Web of Science

  45. Conditioned medium from stem cells derived from human exfoliated deciduous teeth ameliorates NASH via the Gut-Liver axis

    Muto Hisanori, Ito Takanori, Tanaka Taku, Yokoyama Shinya, Yamamoto Kenta, Imai Norihiro, Ishizu Yoji, Maeda Keiko, Honda Takashi, Ishikawa Tetsuya, Kato Asuka, Ohshiro Taichi, Kano Fumiya, Yamamoto Akihito, Sakai Kiyoshi, Hibi Hideharu, Ishigami Masatoshi, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   11 巻 ( 1 ) 頁: 18778   2021年9月

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  46. Revisiting Prognosis After Liver Transplant in Patients Positive for Hepatitis C Virus: Focus on Hepatitis C Recurrence-Unrelated Complications

    Ishigami Masatoshi, Honda Takashi, Ishizu Yoji, Imai Norihiro, Ito Takanori, Yamamoto Kenta, Kamei Hideya, Ogura Yasuhiro, Fujishiro Mitsuhiro

    EXPERIMENTAL AND CLINICAL TRANSPLANTATION   19 巻 ( 9 ) 頁: 935 - 942   2021年9月

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    DOI: 10.6002/ect.2021.0197

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  47. Transient deterioration of albumin-bilirubin scores in early post-dose period of molecular targeted therapies in advanced hepatocellular carcinoma with 50% or higher liver occupation A STROBE-compliant retrospective observational study

    Muto Hisanori, Kuzuya Teiji, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishikawa Tetsuya, Ishigami Masatoshi, Fujishiro Mitsuhiro

    MEDICINE   100 巻 ( 31 ) 頁: e26820   2021年8月

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  48. The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model

    Yoshioka Naoki, Tanaka Miyako, Ochi Kozue, Watanabe Akiko, Ono Kenji, Sawada Makoto, Ogi Tomoo, Itoh Michiko, Ito Ayaka, Shiraki Yukihiro, Enomoto Atsushi, Ishigami Masatoshi, Fujishiro Mitsuhiro, Ogawa Yoshihiro, Suganami Takayoshi

    BIOMEDICINE & PHARMACOTHERAPY   140 巻   頁: 111738   2021年8月

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  49. Feasibility of patency capsule and colon capsule endoscopy in patients with suspected gastrointestinal stenosis: a prospective study

    Otsuka Hiroyuki, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawade Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Iliroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    NAGOYA JOURNAL OF MEDICAL SCIENCE   83 巻 ( 3 ) 頁: 419 - 430   2021年8月

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  50. The impact of hepatitis C virus eradication on hepatocarcinogenesis in haemophiliacs

    Inukai Yosuke, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishigami Masatoshi

    JOURNAL OF HEPATOLOGY   75 巻   頁: S787 - S788   2021年7月

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    記述言語:日本語  

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  51. Endoscopic papillectomy for ampullary adenoma and early adenocarcinoma: Analysis of factors related to treatment outcome and long-term prognosis

    Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Tanaka Hiroyuki, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Hashimoto Senju, Itoh Akihiro, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY   33 巻 ( 5 ) 頁: 858 - 869   2021年7月

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    記述言語:日本語  

    DOI: 10.1111/den.13881

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  52. Lewis score on capsule endoscopy can predict the prognosis in patients with small bowel lesions of Crohn's disease

    Nishikawa Takahiro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 巻 ( 7 ) 頁: 1851 - 1858   2021年7月

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    記述言語:日本語  

    DOI: 10.1111/jgh.15366

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  53. Quality of Life in patients with nonalcoholic fatty liver disease: Structure and related factors focusing on illness uncertainty

    Ozawa Naoki, Sato Kazuki, Sugimura Ayumi, Maki Shigeyoshi, Tanaka Taku, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro, Ishikawa Tetsuya, Ando Shoko

    JAPAN JOURNAL OF NURSING SCIENCE   18 巻 ( 3 ) 頁: e12415   2021年7月

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    記述言語:日本語  

    DOI: 10.1111/jjns.12415

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  54. An initial trial of quantitative evaluation of autoimmune pancreatitis using shear wave elastography and shear wave dispersion in transabdominal ultrasound

    Suzuki Hirotaka, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Uetsuki Kota, Yashika Jun, Yamada Kenta, Yoshikawa Masakatsu, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Fujishiro Mitsuhiro

    PANCREATOLOGY   21 巻 ( 4 ) 頁: 682 - 687   2021年6月

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  55. Immunohistochemical staining for IMP3 in patients with duodenal papilla tumors: assessment of the potential for diagnosing endoscopic resectability and predicting prognosis

    Tanaka Hiroyuki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Ishikawa Eri, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Shimoyama Yoshie, Miyahara Ryoji, Kawabe Naoto, Kuzuya Teiji, Hashimoto Senju, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   21 巻 ( 1 ) 頁: 224   2021年5月

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  56. Measurement of fasting breath hydrogen concentration as a simple diagnostic method for pancreatic exocrine insufficiency

    Uetsuki Kota, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Yamamoto Kenta, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   21 巻 ( 1 ) 頁: 211   2021年5月

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  57. Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in Haemophiliacs

    Yamamoto Takafumi, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    ANTICANCER RESEARCH   41 巻 ( 5 ) 頁: 2569 - 2573   2021年5月

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  58. Clinical Features of Ischemic Enteritis Diagnosed by Double-Balloon Endoscopy

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Ishikawa Takuya, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2021 巻   頁: 8875564   2021年4月

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    記述言語:日本語  

    DOI: 10.1155/2021/8875564

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  59. Variability measurements provide additional value to shear wave elastography in the diagnosis of pancreatic cancer

    Yoshikawa Masakatsu, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kinoshita Fumie, Kawashima Hiroki, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   11 巻 ( 1 ) 頁: 7409   2021年4月

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  60. Filtrated Adipose Tissue-Derived Mesenchymal Stem Cell Lysate Ameliorates Experimental Acute Colitis in Mice

    Nishikawa Takahiro, Maeda Keiko, Nakamura Masanao, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Ito Takanori, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Miyahara Ryoji, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Yamamoto Tokunori, Matsumoto Seiji, Hotta Yuji, Fujishiro Mitsuhiro

    DIGESTIVE DISEASES AND SCIENCES   66 巻 ( 4 ) 頁: 1034 - 1044   2021年4月

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  61. Impact of visceral fat accumulation on the prognosis of patients with cirrhosis

    Ishizu Yoji, Ishigami Masatoshi, Honda Takashi, Imai Norihiro, Ito Takanori, Yamamoto Kenta, Fujishiro Mitsuhiro

    CLINICAL NUTRITION ESPEN   42 巻   頁: 354 - 360   2021年4月

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  62. The epidemiology of NAFLD and lean NAFLD in Japan: a meta-analysis with individual and forecasting analysis, 1995-2040

    Ito Takanori, Ishigami Masatoshi, Zou Biyao, Tanaka Taku, Takahashi Hirokazu, Kurosaki Masayuki, Maeda Mayumi, Thin Khin Naing, Tanaka Kenichi, Takahashi Yuka, Itoh Yoshito, Oniki Kentaro, Seko Yuya, Saruwatari Junji, Kawanaka Miwa, Atsukawa Masanori, Hyogo Hideyuki, Ono Masafumi, Ogawa Eiichi, Barnett Scott D., Stave Christopher D., Cheung Ramsey C., Fujishiro Mitsuhiro, Eguchi Yuichiro, Toyoda Hidenori, Nguyen Mindie H.

    HEPATOLOGY INTERNATIONAL   15 巻 ( 2 ) 頁: 366 - 379   2021年4月

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  63. Endoscopic ultrasound elastography for small solid pancreatic lesions with or without main pancreatic duct dilatation

    Kataoka Kunio, Ishikawa Takuya, Ohno Eizaburo, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Kawashima Hiroki, Hirooka Yoshiki, Fujishiro Mitsuhiro

    PANCREATOLOGY   21 巻 ( 2 ) 頁: 451 - 458   2021年3月

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  64. Simplification of balloon-occluded retrograde transcatheter obliteration procedure using a coaxial double balloon catheter compared with a single-balloon catheter

    Ishizu Yoji, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ito Takanori, Komada Tomohiro, Fujishiro Mitsuhiro

    JAPANESE JOURNAL OF RADIOLOGY   39 巻 ( 3 ) 頁: 296 - 302   2021年3月

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  65. The relationship between oral-origin bacteria in the fecal microbiome and albumin-bilirubin grade in patients with hepatitis C

    Yamamoto Kenta, Honda Takashi, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Nakamura Masanao, Miyahara Ryoji, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   36 巻 ( 3 ) 頁: 790 - 799   2021年3月

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    記述言語:日本語  

    DOI: 10.1111/jgh.15206

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  66. Utility of multiphase contrast enhancement patterns on CEH-EUS for the differential diagnosis of IPMN-derived and conventional pancreatic cancer

    Yashika Jun, Ohno Eizaburo, Ishikawa Takuya, Iida Tadashi, Suzuki Hirotaka, Uetsuki Kota, Yamada Kenta, Yoshikawa Masakatsu, Gibo Noriaki, Shimoyama Yoshie, Ishikawa Eri, Furukawa Kazuhiro, Nakamura Masanao, Honda Takashi, Ishigami Masatoshi, Hirooka Yoshiki, Kawashima Hiroki, Fujishiro Mitsuhiro

    PANCREATOLOGY   21 巻 ( 2 ) 頁: 390 - 396   2021年3月

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  67. Diagnostic yield of colon capsule endoscopy for Crohn's disease lesions in the whole gastrointestinal tract

    Yamada Keisaku, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   21 巻 ( 1 ) 頁: 75   2021年2月

  68. Ustekinumab is effective against small bowel lesions in Crohn's disease: two case reports

    Murate Kentaro, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    CLINICAL JOURNAL OF GASTROENTEROLOGY   14 巻 ( 1 ) 頁: 129 - 135   2021年2月

  69. Hepatitis B Core-Related Antigen to Indicate High Viral Load: Systematic Review and Meta-Analysis of 10,397 Individual Participants

    Yoshida Kyoko, Desbiolles Alice, Feldman Sarah F., Ahn Sang Hoon, Alidjinou Enagnon K., Atsukawa Masanori, Bocket Laurence, Brunetto Maurizia R., Buti Maria, Carey Ivana, Caviglia Gian Paolo, Chen En-Qiang, Cornberg Markus, Enomoto Masaru, Honda Masao, Zu Siederdissen Christoph Hoener, Ishigami Masatoshi, Janssen Harry L. A., Maasoumy Benjamin, Matsui Takeshi, Matsumoto Akihiro, Nishiguchi Shuhei, Riveiro-Barciela Mar, Takaki Akinobu, Tangkijvanich Pisit, Toyoda Hidenori, van Campenhout Margo J. H., Wang Bo, Wei Lai, Yang Hwai- I, Yano Yoshihiko, Yatsuhashi Hiroshi, Yuen Man-Fung, Tanaka Eiji, Lemoine Maud, Tanaka Yasuhito, Shimakawa Yusuke

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   19 巻 ( 1 ) 頁: 46 - +   2021年1月

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  70. Safety and efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma patients with haemophilia

    Yamamoto Takafumi, Imai Norihiro, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Okamoto Shuichi, Kanematsu Takeshi, Suzuki Nobuaki, Matsushita Tadashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    HAEMOPHILIA   27 巻 ( 1 ) 頁: 100 - 107   2021年1月

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    記述言語:日本語  

    DOI: 10.1111/hae.14220

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  71. Systematic review and meta-analysis of the diagnostic and therapeutic yield of small bowel endoscopy in patients with overt small bowel bleeding

    Uchida Genta, Nakamura Masanao, Yamamura Takeshi, Furukawa Kazuhiro, Kawashima Hiroki, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    DIGESTIVE ENDOSCOPY   33 巻 ( 1 ) 頁: 66 - 82   2021年1月

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    記述言語:日本語  

    DOI: 10.1111/den.13669

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  72. Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional Cure

    Honda Takashi, Yamada Norie, Murayama Asako, Shiina Masaaki, Aly Hussein Hassan, Kato Asuka, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Ishigami Masatoshi, Murakami Yoshiki, Tanaka Tomohisa, Moriishi Kohji, Nishitsuji Hironori, Shimotohno Kunitada, Ishikawa Tetsuya, Fujishiro Mitsuhiro, Muramatsu Masamichi, Wakita Takaji, Kato Takanobu

    CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY   12 巻 ( 5 ) 頁: 1583 - 1598   2021年

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  73. Progression After Molecular Targeted Agents: Hepatic Arterial Changes and Transarterial Chemoembolization in Hepatocellular Carcinoma

    Matsuda Noritaka, Imai Norihiro, Kuzuya Teiji, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    IN VIVO   35 巻 ( 2 ) 頁: 1185 - 1189   2021年

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    記述言語:日本語  

    DOI: 10.21873/invivo.12367

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  74. The microbiome can predict mucosal healing in small intestine in patients with Crohn's disease

    Hattori Shun, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Yamamoto Kenta, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY   55 巻 ( 12 ) 頁: 1138 - 1149   2020年12月

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  75. Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy

    Niwa Yoshiki, Nakamura Masanao, Kawashima Hiroki, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ishikawa Takuya, Kakushima Naomi, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Ishigami Masatoshi, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   26 巻 ( 42 ) 頁: 6669 - 6678   2020年11月

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  76. AMINO ACID POLYMORPHISM IN HEPATITIS B VIRUS ASSOCIATED WITH NATURAL CLEARANCE OF HBV DNA AND HBsAg

    Honda Takashi, Yamada None, Murayama Asako, Kato Asuka, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Ishigami Masatoshi, Murakami Yoshiki, Ishikawa Tetsuya, Fujishiro Mitsuhiro, Kato Takanobu

    HEPATOLOGY   72 巻   頁: 508A - 509A   2020年11月

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  77. Endoscopic Activity and Serum TNF-alpha Level at Baseline Are Associated With Clinical Response to Ustekinumab in Crohn's Disease Patients

    Murate Kentaro, Maeda Keiko, Nakamura Masanao, Sugiyama Daisuke, Wada Hirotaka, Yamamura Takeshi, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Miyahara Ryoji, Ishigami Masatoshi, Nishikawa Hiroyoshi, Fujishiro Mitsuhiro

    INFLAMMATORY BOWEL DISEASES   26 巻 ( 11 ) 頁: 1669 - 1681   2020年11月

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    記述言語:日本語  

    DOI: 10.1093/ibd/izaa086

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  78. GUT MICROBIOTA ASSOCIATED WITH THE DIFFERENCE BETWEEN PATIENTS WITH AND WITHOUT HEPATOCELLULAR CARCINOMA IN CHRONIC LIVER DISEASE

    Honda Takashi, Ishigami Masatoshi, Yamamoto Kenta, Ito Takanori, Imai Norihiro, Ishizu Yoji, Fujishiro Mitsuhiro

    HEPATOLOGY   72 巻   頁: 370A - 370A   2020年11月

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  79. IMPROVEMENT OF LIVER FUNCTIONAL RESERVE AFTER SVR IN HCV-PATIENTS WITH COMPENSATED, SEVERE FIBROSIS BY IFN-FREE, DAA COMBINATION TREATMENT-IMPACT OF PRETREATMENT SERUM AFP LEVELS

    Ishigami Masatoshi, Honda Takashi, Ishizu Yoji, Imai Norihiro, Ito Takanori, Yamamoto Kenta, Fujishiro Mitsuhiro

    HEPATOLOGY   72 巻   頁: 564A - 565A   2020年11月

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  80. SAFETY AND EFFICACY OF PERCUTANEOUS RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA PATIENTS WITH HEMOPHILIA

    Yamamoto Takafumi, Ishigami Masatoshi, Yamamoto Kenta, Ito Takanori, Imai Norihiro, Lshizu Yoji, Honda Takashi, Fujishiro Mitsuhiro

    HEPATOLOGY   72 巻   頁: 705A - 706A   2020年11月

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  81. THE EPIDEMIOLOGY OF NAFLD AND LEAN NAFLD IN JAPAN: A SYSTEMATIC REVIEW AND META-ANALYSIS WITH INDIVIDUAL PATIENT LEVEL DATA AND FORECASTING, 1995-2040

    Ito Takanori, Ishigami Masatoshi, Zou Biyao, Tanaka Taku, Takahashi Hirokazu, Kurosaki Masayuki, Maeda Mayumi, Thin Khin Naing, Tanaka Kenichi, Takahashi Yuka, Itoh Yoshito, Oniki Kentaro, Seko Yuya, Saruwatari Junji, Kawanaka Miwa, Atsukawa Masanori, Hyogo Hideyuki, Ono Masafumi, Ogawa Eiichi, Barnette Scott D., Stave Christopher Donald, Cheung Ramsey, Fujishiro Mitsuhiro, Eguchi Yuichiro, Toyoda Hidenori, Nguyen Mindie H.

    HEPATOLOGY   72 巻   頁: 999 - 999   2020年11月

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  82. The albumin-bilirubin score as a predictor of outcomes in Japanese patients with PBC: an analysis using time-dependent ROC

    Ito Takanori, Ishigami Masatoshi, Morooka Hikaru, Yamamoto Kenta, Imai Norihiro, Ishizu Yoji, Honda Takashi, Nishimura Daisaku, Tada Toshifumi, Yasuda Satoshi, Toyoda Hidenori, Kumada Takashi, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁: 17812   2020年10月

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  83. Drug-Induced Liver Injury by Checkpoint Inhibitors: Benefit of a Causality Assessment Tool

    Weber Sabine, Benesic Andreas, Ishigami Masatoshi, Gerbes Alexander L.

    HEPATOLOGY COMMUNICATIONS   4 巻 ( 10 ) 頁: 1552 - 1554   2020年10月

  84. What is the role of measuring shear wave dispersion using shear wave elastography in pancreatic parenchyma?

    Suzuki Hirotaka, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Hashimoto Senju, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    JOURNAL OF MEDICAL ULTRASONICS   47 巻 ( 4 ) 頁: 575 - 581   2020年10月

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  85. Efficacy and Safety of Sorafenib in Unresectable Hepatocellular Carcinoma with Bile Duct Invasion

    Tanaka Taku, Kuzuya Teiji, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishikawa Tetsuya, Fujishiro Mitsuhiro

    ONCOLOGY   98 巻 ( 9 ) 頁: 621 - 629   2020年9月

  86. Revisiting the indications for liver transplantation in cirrhotic patients considering the long-term outcomes of cirrhotic patients

    Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Kamei Hideya, Ogura Yasuhiro, Fujishiro Mitsuhiro

    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES   27 巻 ( 9 ) 頁: 655 - 662   2020年9月

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    記述言語:日本語  

    DOI: 10.1002/jhbp.777

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  87. Limitation of non-transplant treatment and proper timing for liver transplantation in patients with hepatocellular carcinoma considering long-term survival

    Nomura Aya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Kamei Hideya, Onishi Yasuharu, Ogura Yasuhiro, Fujishiro Mitsuhiro

    MEDICINE   99 巻 ( 28 ) 頁: e21161   2020年7月

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  88. Serum Nutritional Markers as Prognostic Factors for Hepatic and Extrahepatic Carcinogenesis in Japanese Patients with Nonalcoholic Fatty Liver Disease

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishikawa Tetsuya, Toyoda Hidenori, Kumada Takashi, Fujishiro Mitsuhiro

    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL   72 巻 ( 5 ) 頁: 884 - 891   2020年7月

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  89. Complete response of advanced hepatocellular carcinoma achieved by sorafenib dose re-escalation after failure of long-term low-dose-sorafenib treatment combined with transcatheter arterial chemoembolization: a case report

    Muto Hisanori, Kuzuya Teiji, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishikawa Tetsuya, Ishigami Masatoshi, Fujishiro Mitsuhiro

    CLINICAL JOURNAL OF GASTROENTEROLOGY   13 巻 ( 3 ) 頁: 397 - 402   2020年6月

  90. Correlation of serum zinc levels with pathological and laboratory findings in patients with nonalcoholic fatty liver disease

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishikawa Tetsuya, Toyoda Hidenori, Kumada Takashi, Fujishiro Mitsuhiro

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY   32 巻 ( 6 ) 頁: 748 - 753   2020年6月

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  91. Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies

    Mizuno Kazuyuki, Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Kawashima Hiroki, Inukai Yosuke, Toyoda Hidenori, Yokota Kenji, Hase Tetsunari, Maeda Osamu, Kiyoi Hitoshi, Nagino Masato, Hibi Hideharu, Kodera Yasuhiro, Fujimoto Yasushi, Sone Michihiko, Gotoh Momokazu, Ando Yuichi, Akiyama Masashi, Hasegawa Yoshinori, Fujishiro Mitsuhiro

    JOURNAL OF GASTROENTEROLOGY   55 巻 ( 6 ) 頁: 653 - 661   2020年6月

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  92. Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta -Analysis

    Taylor Rod S., Taylor Rebecca J., Bayliss Sue, Hagstrom Hannes, Nasr Patrik, Schattenberg Jorn M., Ishigami Masatoshi, Toyoda Hidenori, Wong Vincent Wai-Sun, Peleg Noam, Shlomai Amir, Sebastiani Giada, Seko Yuya, Bhala Neeraj, Younossi Zobair M., Anstee Quentin M., McPherson Stuart, Newsome Philip N.

    GASTROENTEROLOGY   158 巻 ( 6 ) 頁: 1611 - +   2020年5月

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  93. Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.

    Taylor RS, Taylor RJ, Bayliss S, Hagström H, Nasr P, Schattenberg JM, Ishigami M, Toyoda H, Wai-Sun Wong V, Peleg N, Shlomai A, Sebastiani G, Seko Y, Bhala N, Younossi ZM, Anstee QM, McPherson S, Newsome PN

    Gastroenterology   158 巻 ( 6 ) 頁: 1611 - 1625.e12   2020年5月

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    記述言語:英語  

    DOI: 10.1053/j.gastro.2020.01.043

    PubMed

  94. Nonexposed wall-inversion surgery as a novel local resection method for neoplasms in the gastrointestinal tract

    Fujishiro Mitsuhiro, Furukawa Kazuhiro, Yamamura Takeshi, Nakamura Masanao, Honda Takashi, Maeda Osamu, Ishigami Masatoshi, Kawashima Hiroki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   82 巻 ( 2 ) 頁: 175 - 182   2020年5月

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  95. Initial Experience of Ramucirumab Treatment After Lenvatinib Failure for Patients With Advanced Hepatocellular Carcinoma

    Kuzuya Teiji, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishikawa Tetsuya, Fujishiro Mitsuhiro

    ANTICANCER RESEARCH   40 巻 ( 4 ) 頁: 2089 - 2093   2020年4月

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  96. Sorafenib vs. Lenvatinib as First-line Therapy for Advanced Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis

    Kuzuya Teiji, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishikawa Tetsuya, Fujishiro Mitsuhiro

    ANTICANCER RESEARCH   40 巻 ( 4 ) 頁: 2283 - 2290   2020年4月

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  97. Diagnosis of vascular invasion in pancreatic ductal adenocarcinoma using endoscopic ultrasound elastography

    Yamada Kenta, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Tanaka Hiroyuki, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    BMC GASTROENTEROLOGY   20 巻 ( 1 ) 頁: 81   2020年3月

  98. Double-balloon endoscopic retrograde cholangiopancreatography for patients who underwent liver operation: A retrospective study

    Nishio Ryo, Kawashima Hiroki, Nakamura Masanao, Ohno Eizaburo, Ishikawa Takuya, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Tanaka Hiroyuki, Sakai Daisuke, Miyahara Ryoji, Ishigami Masatoshi, Hirooka Yoshiki, Fujishiro Mitsuhiro

    WORLD JOURNAL OF GASTROENTEROLOGY   26 巻 ( 10 ) 頁: 1056 - 1066   2020年3月

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  99. Favorable radiological antitumor response at 2 weeks after starting lenvatinib for patients with advanced hepatocellular carcinoma

    Kuzuya Teiji, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishikawa Tetsuya, Fujishiro Mitsuhiro

    HEPATOLOGY RESEARCH   50 巻 ( 3 ) 頁: 374 - 381   2020年3月

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    記述言語:日本語  

    DOI: 10.1111/hepr.13452

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  100. Relationship Between Adverse Events and Microbiomes in Advanced Hepatocellular Carcinoma Patients Treated With Sorafenib

    Yamamoto Kenta, Kuzuya Teiji, Honda Takashi, Ito Takanori, Ishizu Yoji, Nakamura Masanao, Miyahara Ryoji, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    ANTICANCER RESEARCH   40 巻 ( 2 ) 頁: 665 - 676   2020年2月

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  101. Usefulness of Endoscopic Ultrasound Elastography Combined With the Strain Ratio in the Estimation of Treatment Effect in Autoimmune Pancreatitis

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Tanaka Hiroyuki, Maeda Keiko, Sawada Tsunaki, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Fujishiro Mitsuhiro

    PANCREAS   49 巻 ( 2 ) 頁: E21 - E22   2020年2月

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  102. Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects

    Kawakubo Mitsuhiro, Tanaka Miyako, Ochi Kozue, Watanabe Akiko, Saka-Tanaka Marie, Kanamori Yohei, Yoshioka Naoki, Yamashita Satoko, Goto Moritaka, Itoh Michiko, Shirakawa Ibuki, Kanai Sayaka, Suzuki Hiromi, Sawada Makoto, Ito Ayaka, Ishigami Masatoshi, Fujishiro Mitsuhiro, Arima Hiroshi, Ogawa Yoshihiro, Suganami Takayoshi

    SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁: 983   2020年1月

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  103. Effect of weight change and lifestyle modifications on the development or remission of nonalcoholic fatty liver disease: sex-specific analysis

    Yoshioka Naoki, Ishigami Masatoshi, Watanabe Yasuko, Sumi Hajime, Doisaki Masao, Yamaguchi Takeo, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishikawa Tetsuya, Haruta Jun-ichi, Fujishiro Mitsuhiro

    SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁: 481   2020年1月

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  104. Rapid increase of platelet counts during antiviral therapy in patients with hepatitis C virus infection

    Ishizu Yoji, Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Kuzuya Teiji, Ito Takanori, Fujishiro Mitsuhiro

    HEPATOLOGY RESEARCH   50 巻 ( 1 ) 頁: 47 - 56   2020年1月

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    記述言語:日本語  

    DOI: 10.1111/hepr.13426

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  105. A Prospective Study of Factors Associated with Abdominal Pain in Patients during Unsedated Colonoscopy Using a Magnifying Endoscope

    Suzuki Hiroto, Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Takuya, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    INTERNAL MEDICINE   59 巻 ( 15 ) 頁: 1795 - 1801   2020年

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  106. Refractory Ulcerative Colitis Improved by Scheduled Combination Therapy of Vedolizumab and Granulocyte and Monocyte Adsorptive Apheresis

    Nakamura Masanao, Yamamura Takeshi, Maeda Keiko, Sawada Tsunaki, Mizutani Yasuyuki, Ishikawa Eri, Ohashi Ayako, Kajikawa Go, Furukawa Kazuhiro, Ohno Eizaburo, Honda Takashi, Kawashima Hiroki, Ishigami Masatoshi, Fujishiro Mitsuhiro

    INTERNAL MEDICINE   59 巻 ( 23 ) 頁: 3009 - 3014   2020年

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  107. Sarcopenia impairs health-related quality of life in cirrhotic patients

    Ando Yusuke, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishikawa Tetsuya, Fujishiro Mitsuhiro

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY   31 巻 ( 12 ) 頁: 1550 - 1556   2019年12月

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  108. CHANGES OF MICROBIOTA AFTER HEPATITIS C VIRUS ERADICATION

    Honda Takashi, Ishigami Masatoshi, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Fujishiro Mitsuhiro

    HEPATOLOGY   70 巻   頁: 1160A - 1161A   2019年10月

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  109. DO HEPATOLOGISTS FOLLOW-UP LOW REPLICATIVE HEPATITIS B VIRUS INACTIVE CARRIERS EFFECTIVELY? A MULTI-CENTER STUDY WITH 2,640 HBV PATIENTS IDENTIFIED AT THEIR INITIAL VISITS

    Matono Tomomitsu, Isomoto Hajime, Inoue Takako, Tanaka Yasuhito, Ishigami Masatoshi, Suetsugu Atsushi, Enomoto Masaru, Sato Syuuichi, Sakai Akito, Hidaka Isao, Ogawa Koji, Inoue Jun, Kondo Yasuteru, Ide Tatsuya, Kakizaki Satoru, Kobayashi Yoshimasa, Genda Takuya, Korenaga Masaaki

    HEPATOLOGY   70 巻   頁: 588A - 588A   2019年10月

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    記述言語:日本語  

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  110. Increased hardness of the underlying pancreas correlates with the presence of intraductal papillary-mucinous neoplasm in a limited number of cases

    Koya Toshinari, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi, Hirooka Yoshiki

    JOURNAL OF MEDICAL ULTRASONICS   46 巻 ( 4 ) 頁: 441 - 447   2019年10月

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  111. NON-INVASIVE SCREENING FOR DETECTING ESOPHAGOGASTRIC VARICES IN CHILDREN WITH BILIARY ATRESIA

    Yokoyama Shinya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Shirota Chiyoe, Uchida Hiroo, Fujishiro Mitsuhiro

    HEPATOLOGY   70 巻   頁: 200A - 200A   2019年10月

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  112. INDICATION FOR HCC TREATMENT IN RECENT ERA-PROPOSAL OF THE NEW PRIORITY FOR LIVER TRANSPLANTATION IN PATIENTS WITH HCC

    Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Fujishiro Mitsuhiro

    HEPATOLOGY   70 巻   頁: 543A - 544A   2019年10月

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    記述言語:日本語  

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  113. Spleen stiffness by 2-D shear wave elastography is the most accurate predictor of high-risk esophagogastric varices in children with biliary atresia

    Yokoyama Shinya, Ishigami Masatoshi, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ito Takanori, Hirooka Yoshiki, Tanaka Yujiro, Tainaka Takahisa, Shirota Chiyoe, Chiba Kosuke, Uchida Hiroo, Fujishiro Mitsuhiro

    HEPATOLOGY RESEARCH   49 巻 ( 10 ) 頁: 1162 - 1168   2019年10月

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    記述言語:日本語  

    DOI: 10.1111/hepr.13381

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  114. UTILITY OF THE ALBUMIN-BILIRUBIN SCORE FOR PREDICTING PROGNOSIS IN JAPANESE PATIENTS WITH PRIMARY BILIARY CHOLANGITIS: AN ANALYSIS USING TIME-DEPENDENT RECEIVER OPERATING CHARACTERISTICS

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Yasuda Satoshi, Toyoda Hidenori, Kumada Takashi, Fujishiro Mitsuhiro

    HEPATOLOGY   70 巻   頁: 789A - 790A   2019年10月

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    記述言語:日本語  

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  115. Antifibrotic Effects of 1,25(OH)(2)D-3 on Nonalcoholic Steatohepatitis in Female Mice

    Ma Lingyun, Ishigami Masatoshi, Honda Takashi, Yokoyama Shinya, Yamamoto Kenta, Ishizu Yoji, Kuzuya Teiji, Hayashi Kazuhiko, Hirooka Yoshiki, Goto Hidemi

    DIGESTIVE DISEASES AND SCIENCES   64 巻 ( 9 ) 頁: 2581 - 2590   2019年9月

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  116. Clinical characteristics and outcomes of candidates for second-line therapy, including regorafenib and ramucirumab, for advanced hepatocellular carcinoma after sorafenib treatment

    Kuzuya Teiji, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishikawa Tetsuya, Hirooka Yoshiki, Fujishiro Mitsuhiro

    HEPATOLOGY RESEARCH   49 巻 ( 9 ) 頁: 1054 - 1065   2019年9月

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    記述言語:日本語  

    DOI: 10.1111/hepr.13358

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  117. The relationship between portal hypertension and the microbiome

    Yamamoto K., Honda T., Hattori S., Pu L. Zorron Cheng Tao, Ito T., Yamamura T., Ishizu Y., Kuzuya T., Ishigami M., Fujishiro M.

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻   頁: 106 - 107   2019年9月

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    記述言語:日本語  

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  118. THE PROPAGATION DISPLAY METHOD IMPROVES THE REPRODUCIBILITY OF PANCREATIC SHEAR WAVE ELASTOGRAPHY

    Hashizume Kiyotaka, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kawai Manabu, Suhara Hiroki, Takeyama Tomoaki, Koya Toshinari, Tanaka Hiroyuki, Sakai Daisuke, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Kuwahara Takamichi, Hashimoto Senju, Goto Hidemi

    ULTRASOUND IN MEDICINE AND BIOLOGY   45 巻 ( 8 ) 頁: 2242 - 2247   2019年8月

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  119. Comparison of 8-and 10-mm diameter fully covered self-expandable metal stents: A multicenter prospective study in patients with distal malignant biliary obstruction

    Kawashima Hiroki, Hashimoto Senju, Ohno Eizaburo, Ishikawa Takuya, Morishima Tomomasa, Matsubara Hiroshi, Sugimoto Hiroyuki, Nonogaki Koji, Kanamori Akira, Hara Kazuo, Kuwahara Takamichi, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Ando Masahiko, Hirooka Yoshiki

    DIGESTIVE ENDOSCOPY   31 巻 ( 4 ) 頁: 439 - 447   2019年7月

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    記述言語:日本語  

    DOI: 10.1111/den.13366

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  120. Efficacy and safety of glecaprevir and pibrentasvir treatment for 8 or 12weeks in patients with recurrent hepatitis C after liver transplantation: a Japanese multicenter experience

    Ueda Yoshihide, Kobayashi Tsuyoshi, Ikegami Toru, Miuma Satoshi, Mizuno Shugo, Akamatsu Nobuhisa, Takaki Akinobu, Ishigami Masatoshi, Takatsuki Mitsuhisa, Sugawara Yasuhiko, Maehara Yoshihiko, Uemoto Shinji, Seno Hiroshi

    JOURNAL OF GASTROENTEROLOGY   54 巻 ( 7 ) 頁: 660 - 666   2019年7月

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  121. Association between core mutations and annual decline rate of HBVDNA and HBsAg in chronic hepatitis B patients treated with nucleoside analogue

    Honda Takashi, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Fujishiro Mitsuhiro

    JOURNAL OF HEPATOLOGY   70 巻 ( 1 ) 頁: E258 - E258   2019年4月

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    記述言語:日本語  

    Web of Science

  122. Association between gut microbiota and hepatocellular carcinoma in patients with chronic liver disease

    Honda Takashi, Ishigami Masatoshi, Yamamoto Kenta, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Fujishiro Mitsuhiro

    JOURNAL OF HEPATOLOGY   70 巻 ( 1 ) 頁: E512 - E513   2019年4月

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    記述言語:日本語  

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  123. Serum Zinc levels as a prognostic factor for extra-hepatic carcinogenesis in Japanese patients with non-alcoholic liver disease

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Fujishiro Mitsuhiro

    JOURNAL OF HEPATOLOGY   70 巻 ( 1 ) 頁: E298 - E298   2019年4月

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    記述言語:日本語  

    Web of Science

  124. The early clinical response at 2 weeks of lenvatinib therapy for patients with advanced HCC

    Kuzuya Teiji, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Honda Takashi, Fujishiro Mitsuhiro

    JOURNAL OF HEPATOLOGY   70 巻 ( 1 ) 頁: E611 - E611   2019年4月

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    記述言語:日本語  

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  125. The optimal cut-off points of FIB-4 index for predicting the incidences of HCC and extra-hepatic malignancies in biopsyproven Japanese NAFLD patients

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Fujishiro Mitsuhiro

    JOURNAL OF HEPATOLOGY   70 巻 ( 1 ) 頁: E775 - E775   2019年4月

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    記述言語:日本語  

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  126. Complete response by vitamin K2 analog monotherapy in sorafenib-failure advanced hepatocellular carcinoma: A case report

    Kuzuya Teiji, Ishigami Masatoshi, Ishizu Yoji, Honda Takashi, Hayashi Kazuhiko, Ishikawa Tetsuya, Hirooka Yoshiki, Goto Hidemi

    HEPATOLOGY RESEARCH   49 巻 ( 3 ) 頁: 360 - 364   2019年3月

  127. Influence of proton pump inhibitors on microbiota in chronic liver disease patients

    Yamamoto Kenta, Ishigami Masatoshi, Honda Takashi, Takeyama Tomoaki, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Hayashi Kazuhiko, Goto Hidemi, Hirooka Yoshiki

    HEPATOLOGY INTERNATIONAL   13 巻 ( 2 ) 頁: 234 - 244   2019年3月

  128. Successful treatment of esophageal bleeding due to rupture of major aortopulmonary collateral arteries by transcatheter arterial embolization

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Matsushima Masaya, Kato Taichi, Hirooka Yoshiki

    CLINICAL JOURNAL OF GASTROENTEROLOGY   12 巻 ( 1 ) 頁: 20 - 24   2019年2月

  129. Utility and limitations of noninvasive fibrosis markers for predicting prognosis in biopsy-proven Japanese non-alcoholic fatty liver disease patients

    Ito Takanori, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hayashi Kazuhiko, Nishimura Daisaku, Toyoda Hidenori, Kumada Takashi, Goto Hidemi, Hirooka Yoshiki

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   34 巻 ( 1 ) 頁: 207 - 214   2019年1月

  130. Transabdominal ultrasound elastography of the esophagogastric junction predicts reflux esophagitis

    Suhara Hiroki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi

    JOURNAL OF MEDICAL ULTRASONICS   46 巻 ( 1 ) 頁: 99 - 104   2019年1月

  131. Clinical Impact of EUS-Guided Fine Needle Biopsy Using a Novel Franseen Needle for Histological Assessment of Pancreatic Diseases

    Ishikawa Takuya, Kawashima Hiroki, Ohno Eizaburo, Tanaka Hiroyuki, Sakai Daisuke, Iida Tadashi, Nishio Ryo, Yamamura Takeshi, Furukawa Kazuhiro, Nakamura Masanao, Miyahara Ryoji, Hashimoto Senju, Ishigami Masatoshi, Hirooka Yoshiki

    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2019 巻   頁: 8581743   2019年

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    記述言語:日本語  

    DOI: 10.1155/2019/8581743

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  132. Successful Treatment of Hepatocellular Carcinoma with Regorafenib after Sorafenib-induced Hypersensitivity

    Yoshioka Naoki, Kuzuya Teiji, Ito Takanori, Ishizu Yoji, Honda Takashi, Ishikawa Tetsuya, Ishigami Masatoshi, Fujishiro Mitsuhiro

    INTERNAL MEDICINE   58 巻 ( 19 ) 頁: 2803 - 2808   2019年

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  133. The Prevalence of Mixed Hepatitis C Virus Genotype Infection and Its Effect on the Response to Direct-Acting Antivirals Therapy

    Hayashi Kazuhiko, Tachi Kosuke, Shimizu Yuko, Nagano Kenichi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishigami Masatoshi, Hirooka Yoshiki, Hattori Masashi, Goto Hidemi

    INTERVIROLOGY   62 巻 ( 1 ) 頁: 23 - 29   2019年

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    記述言語:日本語  

    DOI: 10.1159/000499691

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  134. Late relapse of hepatitis C virus in patients with sustained virological response after daclatasvir and asunaprevir therapy

    Hayashi Kazuhiko, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hirooka Yoshiki, Toyoda Hidenori, Kumada Takashi, Hattori Masashi, Katano Yoshiaki, Goto Hidemi

    JOURNAL OF VIRAL HEPATITIS   25 巻 ( 12 ) 頁: 1446 - 1451   2018年12月

  135. Utility of contrast-enhanced ultrasonography with perflubutane in evaluating indications for diagnostic percutaneous tumor biopsy in a case of hepatic sclerosed hemangioma

    Ando Yusuke, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hirooka Yoshiki

    CLINICAL JOURNAL OF GASTROENTEROLOGY   11 巻 ( 6 ) 頁: 514 - 520   2018年12月

  136. Substitutions in interferon sensitivity-determining region and hepatocarcinogenesis after hepatitis C virus eradication

    Yasuda Satoshi, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hayashi Kazuhiko, Toyoda Hidenori, Kumada Takashi, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 巻 ( 11 ) 頁: 1904 - 1911   2018年11月

  137. Association between Core Mutations Induced By Interferon Therapy and Annual Decline Rate of Hbvdna in Chronic Hepatitis B Patients

    Honda Takashi, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Hirooka Yoshiki

    HEPATOLOGY   68 巻   頁: 1233A - 1234A   2018年10月

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  138. Comparison of Gut Microbiota and Predicted Functional Metagenome in Hepatitis C Patients with and without Advanced Fibrosis Categorized By FIB4-Index

    Yamamoto Kenta, Ishigami Masatoshi, Ito Takanori, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hirooka Yoshiki

    HEPATOLOGY   68 巻   頁: 590A - 590A   2018年10月

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  139. Late Relapse and Molecular Analysis of Hepatitis C Virus in Patients with Sustained Virological Response By All Oral Direct Acting Antivirals Therapy

    Hayashi Kazuhiko, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Ishigami Masatoshi, Shimizu Yuko, Tachi Kousuke, Goto Hidemi

    HEPATOLOGY   68 巻   頁: 927A - 927A   2018年10月

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  140. Interferon-Free Antiviral Therapy Rapidly Improves Thrombocytopenia in Patients with Advanced Chronic Hepatitis C

    Ishizu Yoji, Ishigami Masatoshi, Ito Takanori, Kuzuya Teiji, Honda Takashi, Hirooka Yoshiki

    HEPATOLOGY   68 巻   頁: 1157A - 1158A   2018年10月

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  141. Skeletal muscle fat deposition is associated with hepatocellular carcinoma development in patients with chronic liver disease

    Tachi Yoshihiko, Kozuka Akihiro, Hirai Takanori, Kojima Yuko, Ishizu Yoji, Honda Takashi, Kuzuya Teiji, Hayashi Kazuhiko, Ishigami Masatoshi, Goto Hidemi

    NUTRITION   54 巻   頁: 83 - 88   2018年10月

  142. Predictive ability of shear wave elastography for pruritus in chronic hepatitis C patients with sustained virological response

    Tachi Yoshihiko, Hirai Takanori, Kojima Yuko, Ishizu Yoji, Honda Takashi, Kuzuya Teiji, Hayashi Kazuhiko, Ishigami Masatoshi, Goto Hidemi, Katano Yoshiaki

    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY   30 巻 ( 9 ) 頁: 1066 - 1072   2018年9月

  143. Effectiveness of a modified 6-Fr endoscopic nasobiliary drainage catheter for patients with preoperative perihilar cholangiocarcinoma

    Kawashima Hiroki, Hirooka Yoshiki, Ohno Eizaburo, Ishikawa Takuya, Miyahara Ryoji, Watanabe Osamu, Hayashi Kazuhiko, Ishigami Masatoshi, Hashimoto Senju, Ebata Tomoki, Nagino Masato, Goto Hidemi

    ENDOSCOPY INTERNATIONAL OPEN   6 巻 ( 8 ) 頁: E1020 - E1030   2018年8月

  144. Objective evaluation of blood flow in the small-intestinal villous: quantification of findings from dynamic endoscopy with concomitant narrow-band imaging

    Takeyama Tomoaki, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Ishigami Masatoshi, Goto Hidemi

    ENDOSCOPY INTERNATIONAL OPEN   6 巻 ( 8 ) 頁: E941 - E949   2018年8月

  145. Diagnostic Usefulness of APRI and FIB-4 for the Prediction of Liver Fibrosis After Liver Transplantation in Patients Infected with Hepatitis C Virus

    Imai H., Kamei H., Onishi Y., Ishizu Y., Ishigami M., Goto H., Ogura Y.

    TRANSPLANTATION PROCEEDINGS   50 巻 ( 5 ) 頁: 1431 - 1436   2018年6月

  146. Daclatasvir and asunaprevir treatment in patients infected by genotype 1b of hepatitis C virus with no or subtle resistant associated substitutions (RAS) in NS5A-Y93

    Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ishikawa Tetsuya, Nakano Isao, Urano Fumihiro, Kumada Takashi, Yoshioka Kentaro, Hirooka Yoshiki, Goto Hidemi

    JOURNAL OF MEDICAL VIROLOGY   90 巻 ( 4 ) 頁: 736 - 744   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jmv.24978

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  147. Naturally occurring drug resitance substitutions in the NS5A and NS5B regions in Hepatitis C virus genotype 2 and response to sofosbuvir plus ribavirin therapy

    Hayashi K., Ishigami M., Ishizu Y., Kazuya T., Honda T., Hirooka Y., Goto H.

    JOURNAL OF HEPATOLOGY   68 巻   頁: S297 - S297   2018年4月

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  148. Secreted ectodomain of SIGLEC-9 and MCP-1 ameliorate acute liver failure in rats by altering bone marrow macrophage polarity

    Ito T., Ishigami M., Yamamoto A., Ishizu Y., Kazuya T., Honda T., Hayashi K., Ishikawa T., Hirooka Y., Goto H.

    JOURNAL OF HEPATOLOGY   68 巻   頁: S614 - S614   2018年4月

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  149. Utility and limitation of non-invasive fibrosis markers for predicting the prognosis in biopsy-proven Japanese NAFLD patients

    Ito T., Ishigami M., Ishizu Y., Kazuya T., Honda T., Hayashi K., Ishikawa T., Hirooka Y., Goto H.

    JOURNAL OF HEPATOLOGY   68 巻   頁: S561 - S561   2018年4月

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  150. Cumulative incidence and risk factors for the development of hepatocellular carcinoma in patients with chronic hepatitis B who achieved sustained disappearance of viremia by nucleos(t)ide analog treatment

    Ando Yusuke, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hayashi Kazuhiko, Ishikawa Tetsuya, Nakano Isao, Hirooka Yoshiki, Goto Hidemi

    HEPATOLOGY RESEARCH   48 巻 ( 3 ) 頁: E240-E251   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/hepr.12976

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    PubMed

  151. Comparison of direct sequencing and Invader assay for Y93H mutation and response to interferon-free therapy in hepatitis C virus genotype 1b

    Hayashi Kazuhiko, Ishigami Masatoshi, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Kawashima Hiroki, Ishikawa Tetsuya, Tachi Yoshihiko, Hattori Masashi, Katano Yoshiaki, Goto Hidemi, Hirooka Yoshiki

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   33 巻 ( 1 ) 頁: 249-255   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jgh.13809

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  152. Functional Correlation Between the Pancreas and the Small Intestine in Humans: The First Evaluation Using a Newly Developed Enteroscopy

    Hayashi Daijuro, Hirooka Yoshiki, Kawashima Hiroki, Ohno Eizaburo, Ishikawa Takuya, Kuwahara Takamichi, Kawai Manabu, Yamamura Takeshi, Furukawa Kazuhiro, Funasaka Kohei, Nakamura Masanao, Miyahara Ryoji, Watanabe Osamu, Ishigami Masatoshi, Hashimoto Senju, Goto Hidemi

    PANCREAS   47 巻 ( 5 ) 頁: 601 - 608   2018年

  153. Prognostic Factors Associated with Postprogression Survival in Advanced Hepatocellular Carcinoma Patients Treated with Sorafenib Not Eligible for Second-Line Regorafenib Treatment

    Kuzuya Teiji, Ishigami Masatoshi, Ishizu Yoji, Honda Takashi, Hayashi Kazuhiko, Ishikawa Tetsuya, Nakano Isao, Hirooka Yoshiki, Goto Hidemi

    ONCOLOGY   95 巻 ( 2 ) 頁: 91 - 99   2018年

  154. Pseudomembranous Invasive Tracheobronchial Aspergillosis with Fulminant Hepatitis and Hemophagocytic Syndrome

    Majima Suguru, Okachi Shotaro, Asano Motoyo, Wakahara Keiko, Hashimoto Naozumi, Sato Mitsuo, Ishigami Masatoshi, Hasegawa Yoshinori

    INTERNAL MEDICINE   57 巻 ( 16 ) 頁: 2371 - 2375   2018年

  155. Daclatasvir and asunaprevir treatment in patients with severe liver fibrosis by HCV genotype 1b infection: Real world data. 査読有り

    . Ishigami M, Hayashi K, Honda T, Kuzuya T, Ishizu Y, Ishikawa T, Nakano I, Urano F, Kumada T, Yoshioka K, Goto H, Hirooka Y.

    J Gastroenterol Hepatol   32 巻   頁: 1879-1886   2017年11月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

  156. Daclatasvir and asunaprevir treatment in patients with severe liver fibrosis by hepatitis C virus genotype 1b infection: Real-world data

    Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ishikawa Tetsuya, Nakano Isao, Urano Fumihiro, Kumada Takashi, Yoshioka Kentaro, Goto Hidemi, Hirooka Yoshiki

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 巻 ( 11 ) 頁: 1879-1886   2017年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/jgh.13779

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    PubMed

  157. Low skeletal muscle mass predicts early mortality in cirrhotic patients with acute variceal bleeding

    Ishizu Yoji, Ishigami Masatoshi, Kuzuya Teiji, Honda Takashi, Hayashi Kazuhiko, Ishikawa Tetsuya, Hirooka Yoshiki, Goto Hidemi

    NUTRITION   42 巻   頁: 87-91   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.nut.2017.06.004

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  158. Liver stiffness measurement predicts hepatocellular carcinoma development in patients treated with direct-acting antivirals

    Tachi Yoshihiko, Hirai Takanori, Kojima Yuko, Ishizu Yoji, Honda Takashi, Kuzuya Teiji, Hayashi Kazuhiko, Ishigami Masatoshi, Goto Hidemi

    JGH OPEN   1 巻 ( 1 ) 頁: 44 - 49   2017年9月

  159. Core I97L mutation in conjunction with P79Q is associated with persistent low HBV DNA and HBs antigen clearance in patients with chronic hepatitis B

    Honda T., Ishigami M., Ishizu Y., Kuzuya T., Hayashi K., Ishikawa T., Murakami Y., Iwadate M., Umeyama H., Toyoda H., Kumada T., Katano Y., Goto H., Hirooka Y.

    CLINICAL MICROBIOLOGY AND INFECTION   23 巻 ( 6 )   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.cmi.2016.12.014

    Web of Science

  160. Multifaceted therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for acute liver failure in rats

    Matsushita Yoshihiro, Ishigami Masatoshi, Matsubara Kohki, Kondo Megumi, Wakayama Hirotaka, Goto Hidemi, Ueda Minoru, Yamamoto Akihito

    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE   11 巻 ( 6 ) 頁: 1888-1896   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/term.2086

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  161. Real World Data of Daclatasvir and Asunaprevir Combination Therapy for HCV Genotype 1b Infection in Patients With Renal Dysfunction

    Ishigami Masatoshi, Hayashi Kazuhiko, Honda Takashi, Kuzuya Teiji, Ishizu Yoji, Ishikawa Tetsuya, Nakano Isao, Urano Fumihiro, Kumada Takashi, Yoshioka Kentaro, Goto Hidemi, Hirooka Yoshiki

    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY   15 巻 ( 5 ) 頁: 787 - 788   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.cgh.2016.12.009

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  162. Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice

    Honda Takashi, Ishigami Masatoshi, Luo Fangqiong, Lingyun Ma, Ishizu Yoji, Kuzuya Teiji, Hayashi Kazuhiko, Nakano Isao, Ishikawa Tetsuya, Feng Guo-Gang, Katano Yoshiaki, Kohama Tomoya, Kitaura Yasuyuki, Shimomura Yoshiharu, Goto Hidemi, Hirooka Yoshiki

    METABOLISM-CLINICAL AND EXPERIMENTAL   69 巻   頁: 177-187   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.metabol.2016.12.013

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  163. Secreted Ectodomain of SIGLEC-9 and MCP-1 Synergistically Improve Acute Liver Failure in Rats by Altering Macrophage Polarity

    Ito Takanori, Ishigami Masatoshi, Matsushita Yoshihiro, Hirata Marina, Matsubara Kohki, Ishikawa Tetsuya, Hibi Hideharu, Ueda Minoru, Hirooka Yoshiki, Goto Hidemi, Yamamoto Akihito

    SCIENTIFIC REPORTS   7 巻   頁: 44043   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/srep44043

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  164. Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells on Concanavalin A-Induced Acute Liver Injury in Mice.

    Yoshizumi Y, Yukawa H, Iwaki R, Fujinaka S, Kanou A, Kanou Y, Yamada T, Nakagawa S, Ohara T, Nakagiri K, Ogihara Y, Tsutsui Y, Hayashi Y, Ishigami M, Baba Y, Ishikawa T

    Cell medicine   9 巻 ( 1-2 ) 頁: 21 - 33   2017年1月

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  165. Phenotypes and Chronic Organ Damage May Be Different among Siblings with Wilson's Disease

    Yahata Shinsuke, Yung Seitetsu, Mandai Mari, Nagahara Takakazu, Kuzume Daisaku, Sakaeda Hiroshi, Wakusawa Shinya, Kato Ayako, Tatsumi Yasuaki, Kato Koichi, Hayashi Hisao, Isaji Ryohei, Sasaki Yoji, Yano Motoyoshi, Hayashi Kazuhiko, Ishigami Masatoshi, Goto Hidemi

    JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY   5 巻 ( 1 ) 頁: 27 - 30   2017年

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科研費 6

  1. 急性肝不全モデル動物における歯髄由来幹細胞の効果-肝臓における炎症と再生の相関

    2015年4月 - 2018年3月

    科学研究費補助金  基盤研究(C)

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    担当区分:研究代表者 

  2. 免疫学的劇症肝炎モデルマウスにおける新たな細胞治療の基礎的検討

    2012年4月 - 2015年3月

    科学研究費補助金  基盤研究(C)

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    担当区分:研究代表者 

  3. 炎症・ウイルス感染環境下での肝構成細胞の免疫・代謝応答の解析

    2011年4月 - 2014年3月

    科学研究費補助金  基盤研究(C)

    石川 哲也

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    担当区分:研究分担者 

  4. 急性肝不全モデル動物におけるMCP-1,sSiglec9の有用性

    研究課題/研究課題番号:18K07936  2018年4月 - 2022年3月

    科学研究費助成事業  基盤研究(C)

    石上 雅敏

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    担当区分:研究代表者 

    配分額:4420000円 ( 直接経費:3400000円 、 間接経費:1020000円 )

    本年度はMCP-1+sSiglec9の2因子投与による急性肝不全モデル動物における生存率向上の直接の作用機序として主に肝再生促進について着目、検討を行った。
    C57BL/6マウスに対し、2.0ml/kgの四塩化炭素(CCl4)投与による急性肝不全モデルマウスを使用。CCl4投与12時間後に薬剤介入し、36、48、60、72時間後にKi-67染色にて肝再生の評価を行った所、2因子投与群、control群とも血清ALT値に比例したKi-67染色の増強と、48、60時間後において強い発現上昇を認め、control群と比較して2因子投与群において発現上昇の強いことがわかった。また、48時間後においては2因子投与群ではcontrol群と比較して炎症抑制性マクロファージマーカーであるCD206、抗炎症サイトカインの一つであるTGF-βの発現増強が認められた。
    また、炎症を介さない肝再生に対する2因子の直接作用を検討するため、肝切除ラットモデルを用いてKi-67発現を検討、肝切除後24時間ではKi-67発現はほとんど見られないものの、48時間で発現が認められるようになった。また、肝切除直後に治療介入として歯髄幹細胞培養上清(SHED-CM)を投与、control群と比較した所、2群に大きな差は認められず、SHED-CM,2因子の作用は抗炎症作用と協調的に働いていることが示唆された。
    培養星細胞株であるLx-2において、SHED-CMの添加により、α-SMA発現の低下、HGF発現の上昇が見られることがわかり、星細胞を静止期に維持する作用があることが示唆された。また、SHED-CMの添加により、Hep-G2細胞のcell viabilityが促進されることが明らかとなり、肝細胞の再生促進を促す可能性があることが示唆された。
    本年度は汎用性検討ということでCCl4急性肝不全モデルマウスにおける検討を行ったが、D-galactosamine誘発ラットモデルの際に見られた炎症惹起型から炎症抑制型マクロファージへの形質転換による抗炎症作用が2因子投与とcontrol群では予想よりも明確な差が見られなかった。原因としてはモデル内の大きなばらつき、ならびにCCl4肝不全モデルにおいてのマクロファージの関与の程度等が考えられ、現在生存率の向上や肝再生促進作用の増強との乖離を検討している所である。
    また、2因子でうまく行かなかったモデルに対しては同時にそもそもの原点であるSHED-CMによるsSiglec-9、およびMCP-1以外の液性因子による作用発現の可能性も考慮しての検討も加えている。このため他モデルでの汎用性の検討に少し時間がかかっている。
    また、現在同時進行にてin vitroモデルによる星細胞の静止期維持作用、および肝再生促進作用の検討も行っている。現在初代肝細胞作成のための条件設定、および、SHED-CM以外に2因子での条件設定に少し時間がかかっている。
    次年度については、モデルの汎用性として新たによりヒトでも起こり得る薬剤性急性肝不全モデルとして有名なアセトアミノフェン(APAP)誘発モデルを使用、2因子の効果を検証する。具体的にはモデルの確立(APAP投与量、2因子投与タイミング)を行った後、炎症関連(TNF-α,TGF-β,IL-6,IL-1β,PAI-1,iNOS,VEGF)、再生関連(HGF),および現在メカニズムの主作用として推定されている抗炎症性マクロファージマーカー(Arginase-1,CD206)の遺伝子発現、またTUNEL染色によるアポトーシス、およびKi67による肝細胞増殖マーカーの免疫組織学的発現を2因子投与群とcontrol群で比較検討を行う。また、これらがすでに肝局在のマクロファージであるKuppfer細胞のレベルで働いているのか、あるいは炎症によって動員される骨髄単球由来のマクロファージの働きであるのかも同時に検討していきたい。
    再生メカニズムについては、動員される再生細胞が肝前駆細胞なのか、あるいは成熟肝細胞の分裂なのか、もしくはその両方なのかを明らかにするため前駆細胞のマーカーであるAFP,CK19発現、また成熟肝細胞のマーカーであるHNF-4α発現の遺伝子発現、およびKi-67との共染色による免疫組織学的検討を行っていく予定である。
    また、肝再生時に重要な液性因子であるHGF分泌の主たる細胞としては星細胞、特に静止期の星細胞が考えられている。2因子投与による静止期、および活性化星細胞の動態をdesmin,α-SMAの発現の有無で評価し、control群と比較する予定である。
    この新たなモデル確立、およびこれらの検討を2因子の他にSHED-CMでの検討でも予定していることから次年度使用額として計上を行っている。

  5. 非B非C型肝癌における腸内細菌叢と治療介入

    研究課題/研究課題番号:17K09418  2017年4月 - 2020年3月

    科学研究費助成事業  基盤研究(C)

    本多 隆, 後藤 秀実, 廣岡 芳樹, 石上 雅敏

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    担当区分:研究分担者 

    マウス肝癌発症モデルにおいてネットワーク解析により腸内細菌は相互に関係し、腫瘍形成や線維化と関連する複数の細菌が存在することを同定した。
    ヒトにおいて肝癌患者では非肝癌患者と比較しActiomyces属などが増加していた。非B非C型肝癌症例では非肝癌症例と比較してVeillonella属などが増加しており、口腔内常在菌など特定な腸内細菌が肝発癌例と非癌例の違いに関与している可能性が示唆された。
    肝癌の原因はHCV、HBVウイルスなどによるものが大多数であったが、ウイルスのコントロールが可能となってきたことから、それ以外の非B非C型肝癌が最近増加している。
    肝発癌促進因子として腸内細菌による肝臓への影響が考えられてきている。
    本研究においてマウスモデルにおける腸内細菌と肝遺伝子発現に関するネットワーク解析により腸内細菌は相互に関係し、腫瘍形成や線維化と関連する複数の細菌が存在することを同定した。またヒト肝疾患からの解析では口腔内常在菌などの腸内細菌叢の違いが肝発癌症例と非肝癌症例との違いに関与している可能性が示唆された。

  6. 急性肝不全モデル動物における歯髄由来幹細胞の効果-肝臓における炎症と再生の相関

    研究課題/研究課題番号:15K08996  2015年4月 - 2018年3月

    石上 雅敏

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    担当区分:研究代表者 

    配分額:4810000円 ( 直接経費:3700000円 、 間接経費:1110000円 )

    急性肝不全はその治癒には自力での肝再生が必要であるが、現在まだ臨床で使用可能な肝再生を誘導する薬剤が存在しない。
    そこで我々は、乳歯歯髄由来幹細胞の培養上清(SHED-CM)の効果を急性肝不全モデルラットにおいて検討、他の幹細胞と比較して高い効果を示した。また、歯髄幹細胞培養上清内に多く含まれる液性因子として、単球-マクロファージの遊走因子であるMCP-1とマクロファージを炎症惹起型から炎症抑制型への変換を行う因子である分泌型Siglec-9を見出し、この2つの液性因子のみでも炎症抑制、肝再生促進効果があることを見出した。
    これらの2因子は新たな急性肝不全治療薬として期待できるものと考える。

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