Updated on 2021/03/18

写真a

 
KOJIMA, Toshihisa
 
Organization
Graduate School of Medicine Program in Integrated Medicine Biomedical Regulation Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor
External link

Degree 1

  1. 医学博士 ( 1998.3   名古屋大学 ) 

Research Interests 1

  1. 軟骨代謝関節リウマチ骨代謝

Research Areas 1

  1. Life Science / Orthopedics

Current Research Project and SDGs 3

  1. Creation of evidence fro treatment of RA

  2. Exploring pathogenesis of OA

  3. Exploring pathogenesis of RA

Research History 8

  1. Nagoya University Graduate school of Medicine   Rheumatology/Orthopedic Surgery   Associate professor

    2018.8

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    Country:Japan

  2. 名古屋大学医学部整形外科 講師

    2010.1

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    Country:Japan

  3. 名古屋大学医学部整形外科 助教

    2007.4 - 2009.12

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    Country:Japan

  4. 名古屋大学医学部整形外科 助手

    2004.4 - 2007.3

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    Country:Japan

  5. 名古屋大学医学部整形外科 非常勤医員

    2000.10 - 2004.3

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    Country:Japan

  6. 国保坂下病院整形外科 副部長

    2000.4 - 2000.9

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    Country:Japan

  7. Shiriners Hospital, Joint Diseases Laboratory, Mcgill University (Montreal. Canada) Postdoctoral fellow

    1998.4 - 2000.3

  8. 半田市立半田病院整形外科 医師

    1992.4 - 1994.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences   Orthopaedics

    1994.4 - 1998.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1984.4 - 1990.3

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    Country: Japan

Professional Memberships 3

  1. The Japanese Orthopaedic Association

  2. Japan College of Rheumatology

    2006.4

  3. The Japanese Society of Cartilage Metabolism

 

Papers 114

  1. Prediction of progression of damage to articular cartilage 2 years after anterior cruciate ligament reconstruction: use of aggrecan and type II collagen biomarkers in a retrospective observational study

    Sobue Yasumori, Kojima Toshihisa, Kurokouchi Kazutoshi, Takahashi Shigeo, Yoshida Hiroaki, Poole Robin, Ishiguro Naoki

    ARTHRITIS RESEARCH & THERAPY   Vol. 19 ( 1 ) page: 265   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13075-017-1471-1

    Web of Science

    PubMed

  2. Validation and reliability of the Timed Up and Go test for measuring objective functional impairment in patients with long-standing rheumatoid arthritis: a cross-sectional study.

    Kojima T, Ishikawa H, Tanaka S, Haga N, Nishida K, Yukioka M, Hashimoto J, Miyahara H, Niki Y, Kimura T, Oda H, Asai S, Funahashi K, Kojima M, Ishiguro N

    International journal of rheumatic diseases     2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1756-185X.13237

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  3. Characteristics of functional impairment in patients with long-standing rheumatoid arthritis based on range of motion of joints: Baseline data from a multicenter prospective observational cohort study to evaluate the effectiveness of joint surgery in the treat-to-target era.

    Kojima T, Ishikawa H, Tanaka S, Haga N, Nishida K, Yukioka M, Hashimoto J, Miyahara H, Niki Y, Kimura T, Oda H, Asai S, Funahashi K, Kojima M, Ishiguro N

    Modern rheumatology     page: 1-8   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14397595.2017.1349593

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  4. Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study.

    Asai S, Fujibayashi T, Oguchi T, Hanabayashi M, Hayashi M, Matsubara H, Ito T, Yabe Y, Watanabe T, Hirano Y, Kanayama Y, Kaneko A, Kato T, Takagi H, Takahashi N, Funahashi K, Takemoto T, Asai N, Watanabe T, Ishiguro N, Kojima T

    Modern rheumatology     page: 1-6   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14397595.2017.1332558

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  5. Two cases of autoimmune pulmonary alveolar proteinosis with rheumatoid arthritis

    Ito Satoru, Wakahara Keiko, Kojima Toshihisa, Takahashi Nobunori, Nishiwaki Kimitoshi, Yamaguchi Etsuro, Hasegawa Yoshinori

    ALLERGOLOGY INTERNATIONAL   Vol. 66 ( 3 ) page: 507-509   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.alit.2017.02.002

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  6. Two cases of autoimmune pulmonary alveolar proteinosis with rheumatoid arthritis. Reviewed

    Ito S, Wakahara K, Kojima T, Takahashi N, Nishiwaki K, Yamaguchi E, Hasegawa Y.

    Allergology International     2017.2

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    DOI: 10.1016/j.alit.2017.02.002.

  7. Laterality of radiographic osteoarthritis of the knee

    Komatsu Daigo, Ikeuchi Kazuma, Kojima Toshihisa, Takegami Yasuhiko, Amano Takafumi, Tsuboi Masaki, Ishiguro Naoki, Hasegawa Yukiharu

    LATERALITY   Vol. 22 ( 3 ) page: 340-353   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/1357650X.2016.1199560

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  8. Integrating patients' perceptions into clinical practice guidelines for the management of rheumatoid arthritis in Japan

    Kojima Masayo, Nakayama Takeo, Otani Takashi, Hasegawa Mieko, Kawahito Yutaka, Kaneko Yuko, Kishimoto Mitsumasa, Hirata Shintaro, Seto Yohei, Endo Hirahito, Ito Hiromu, Kojima Toshihisa, Nishida Keiichiro, Matsushita Isao, Tsutani Kiichiro, Igarashi Ataru, Kamatani Naoyuki, Miyasaka Nobuyuki, Yamanaka Hisashi

    MODERN RHEUMATOLOGY   Vol. 27 ( 6 ) page: 924-929   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14397595.2016.1276511

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  9. Absence of a relationship between joint space narrowing and osteophyte formation in early knee osteoarthritis among Japanese community-dwelling elderly individuals: A cross-sectional study. Reviewed

    Komatsu D, Hasegawa Y, Kojima T, Seki T, Higuchi Y, Ishiguro N

    Modern Rheumatology   Vol. 14   page: 1-8   2016.10

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  10. Mechanical stress loading induces CD44 cleavage in human chondrocytic HCS-2/8 cells. Reviewed

    Kobayakawa T, Takahashi N, Sobue Y, Terabe K, Ishiguro N, Kojima T.

    Biochemical and Biophysical Research Communications   Vol. 478 ( 3 ) page: 1230-1235   2016.9

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  11. Validity of radiographic assessment of the knee joint space using automatic image analysis. Reviewed

    Komatsu D, Hasegawa Y, Kojima T, Seki T, Ikeuchi K, Takegami Y, Amano T, Higuchi Y, Kasai T, Ishiguro N.

    Modern Rheumatology   Vol. 26 ( 5 ) page: 761-766   2016.9

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  12. Hyaluronan Oligosaccharides Induce MMP-1 and -3 via Transcriptional Activation of NF-κB and p38 MAPK in Rheumatoid Synovial Fibroblasts. Reviewed

    Hanabayashi M, Takahashi N, Sobue Y, Hirabara S, Ishiguro N, Kojima T.

    PLOS ONE   Vol. 11 ( 8 )   2016.8

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    DOI: 10.1371/journal.pone.0161875

  13. Simvastatin inhibits CD44 fragmentation in chondrocytes. Reviewed

    Terabe K, Takahashi N, Takemoto T, Knudson W, Ishiguro N, Kojima T.

    Archives of Biochemistry and Biophysics   Vol. 604   page: 1-10   2016.8

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  14. Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study. Reviewed

    Hattori Y, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Terabe K, Yabe Y, Miyake H, Kato T, Takagi H, Hayashi M, Ito T, Kanayama Y, Oguchi T, Takahashi N, Ishikawa H, Funahashi K, Ishiguro N.

    The Journal of Rheumatology   Vol. 43 ( 8 ) page: 1475-1479   2016.8

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  15. Laterality of radiographic osteoarthritis of the knee. Reviewed

    Komatsu D, Ikeuchi K, Kojima T, Takegami Y, Amano T, Tsuboi M, Ishiguro N, Hasegawa Y.

    Laterality   Vol. 27   page: 1-14   2016.6

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  16. Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages. Reviewed

    Matsumoto T, Takahashi N, Kojima T, Yoshioka Y, Ishikawa J, Furukawa K, Ono K, Sawada M, Ishiguro N, Yamamoto A.

    Arthritis Research & Therapy   Vol. 18 ( 1 ) page: 133   2016.6

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  17. Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts. Reviewed

    Watanabe T, Takahashi N, Hirabara S, Ishiguro N, Kojima T.

    PLOS ONE   Vol. 11 ( 4 )   2016.4

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    DOI: 10.1371/journal.pone.0153142

  18. Improved safety of biologic therapy for rheumatoid arthritis over the 8-year period since implementation in Japan: long-term results from a multicenter observational cohort study. Reviewed

    Kojima T, Takahashi N, Funahashi K, Asai S, Terabe K, Kaneko A, Hirano Y, Hayashi M, Miyake H, Oguchi T, Takagi H, Kanayama Y, Yabe Y, Watanabe T, Fujibayashi T, Shioura T, Ito T, Yoshioka Y, Ishikawa H, Asai N, Takemoto T, Kojima M, Ishiguro N.

    Clinical Rheumatology   Vol. 35 ( 4 ) page: 863-871   2016.4

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  19. Predictive factors for achieving low disease activity at 52 weeks after switching from tumor necrosis factor inhibitors to abatacept: results from a multicenter observational cohort study of Japanese patients.

    Kojima T, Takahashi N, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Shioura T, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Terabe K, Takemoto T, Asai N, Ishiguro.

    Clinical Rheumatology   Vol. 35 ( 1 ) page: 219-225   2016.1

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  20. Predictive factors for achieving low disease activity at 52 weeks after switching from tumor necrosis factor inhibitors to abatacept: results from a multicenter observational cohort study of Japanese patients.

    Kojima T, Takahashi N, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Shioura T, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Terabe K, Takemoto T, Asai N, and Ishiguro N.

    Clinical Rheumatology   Vol. 35   page: 219-225   2016

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  21. Concomitant Methotrexate Protects Against Total Knee Arthroplasty in Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitors.

    Asai S, Takahashi N, Funahashi K, Yoshioka Y, Takemoto T, Terabe K, Asai N, Ishiguro N, Kojima T.

    The Journal of Rheumatology   Vol. 42 ( 12 ) page: 2255-2260   2015.12

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  22. Patient-reported outcomes as assessment tools and predictors of long-term prognosis: a 7-year follow-up study of patients with rheumatoid arthritis.

    Kojima M, Kojima T, Suzuki S, Takahashi N, Funahashi K, Asai S, Yoshioka Y, Terabe K, Asai N, Takemoto T, Ishiguro N.

    International Journal of Rheumatic Diseases     2015.11

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    DOI: 10.1111/1756-185X.12789.

  23. The process of collecting and evaluating evidences for the development of Guidelines for the management of rheumatoid arthritis, Japan College of Rheumatology 2014: Utilization of GRADE approach.

    Kojima M, Nakayama T, Kawahito Y, Kaneko Y, Kishimoto M, Hirata S, Seto Y, Endo H, Ito H, Kojima T, Nishida K, Matsushita I, Tsutani K, Igarashi A, Kamatani N, Hasegawa M, Miyasaka N, Yamanaka H.

    Modern Rheumatology   Vol. 12   page: 1-5   2015.8

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  24. Disease activity early in treatment as a predictor of future low disease activity in RA patients treated with iguratimod.

    Yoshioka Y, Takahashi N, Kaneko A, Hirano Y, Kanayama Y, Kanda H, Takagi H, Ito T, Kato T, Saito K, Funahashi K, Asai S, Takemoto T, Terabe K, Asai N, Ishiguro N, Kojima T.

    Modern Rheumatology   Vol. 3   page: 1-6   2015.7

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  25. Concomitant methotrexate and tacrolimus augment the clinical response to abatacept in patients with rheumatoid arthritis with a prior history of biological DMARD use. Reviewed

    Takahashi N, Fujibayashi T, Kida D, Hirano Y, Kato T, Kato D, Saito K, Kaneko A, Yabe Y, Takagi H, Oguchi T, Miyake H, Watanabe T, Hayashi M, Kanayama Y, Funahashi K, Hanabayashi M, Hirabara S, Asai S, Takemoto T, Terabe K, Asai N, Yoshioka Y, Ishiguro N, Kojima T.

    Rheumatol Int.     page: Epub ahead of print   2015.5

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  26. Use of a 12-week observational period for predicting low disease activity at 52 weeks in RA patients treated with abatacept: a retrospective observational study based on data from a Japanese multicentre registry study. Reviewed

    Takahashi N, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Fukaya N, Hayashi M, Tsuboi S, Kanayama Y, Funahashi K, Hanabayashi M, Hirabara S, Asai S, Yoshioka Y, Ishiguro N.

    Rheumatology (Oxford).   Vol. 54 ( 5 ) page: 854-9   2015.5

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  27. Longterm efficacy and safety of abatacept in patients with rheumatoid arthritis treated in routine clinical practice: effect of concomitant methotrexate after 24 weeks. Reviewed

    Takahashi N, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Takemoto T, Terabe K, Asai N, Ishiguro N.

    J Rheumatol.   Vol. 42 ( 5 ) page: 786-93   2015.5

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  28. Effects of concomitant methotrexate on large joint replacement in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors: A multicenter retrospective cohort study in Japan. Reviewed

    Asai S, Kojima T, Oguchi T, Kaneko A, Hirano Y, Yabe Y, Kanayama Y, Takahashi N, Funahashi K, Hanabayashi M, Hirabara S, Yoshioka Y, Takemoto T, Terabe K, Asai N, Ishiguro N.

    Arthritis Care Res (Hoboken).     page: Epub ahead of print   2015.4

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  29. Comparison of efficacy and safety of tacrolimus and methotrexate in combination with abatacept in patients with rheumatoid arthritis; a retrospective observational study in the TBC Registry. Reviewed

    Fujibayashi T, Takahashi N, Kida D, Kaneko A, Hirano Y, Fukaya N, Yabe Y, Oguchi T, Tsuboi S, Miyake H, Takemoto T, Kawasaki M, Ishiguro N, Kojima T.

    Mod Rheumatol.     page: Epub ahead of print   2015.4

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  30. 最新 整形外科医が知っておきたい薬の使い方「II. 関節リウマチ JAK阻害薬(トファシチニブ)」

    小嶋俊久

    関節外科 基礎と臨床   Vol. 34   page: 10月増刊号   2015

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  31. 特集 日本リウマチ学会関節リウマチ診療ガイドライン2014 シムジアⓇ皮下注200mgシリンジ(セルトリズマブ ペゴル)使用生成調査の中間成績に基づく安全性「関節リウマチ診療ガイドライン2014におけるリハビリテーションの意義とその位置づけ」

    小嶋俊久

    Rheumatology Clinical Research   Vol. 4 ( 2 ) page: 33-36   2015

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  32. 特集 関節リウマチ:関節リウマチに対する手術治療の変化と展望―薬物治療の進歩の中で―

    小嶋 俊久

    Pharma Medica   Vol. 32 ( 12 ) page: 49-52   2014.12

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  33. 第4章ガイドライン作成に用いた資料一覧①エビデンスのまとめ

    小嶋 俊久

    関節リウマチ診療ガイドライン2014     page: 163,166,168,170,176,178,180,182   2014.10

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  34. Drug retention rates of second biologic agents after switching from tumor necrosis factor inhibitors for rheumatoid arthritis in Japanese patients on low-dose methotrexate or without methotrexate. Reviewed

    Kobayakawa T, Kojima T, Takahashi N, Hayashi M, Yabe Y, Kaneko A, Shioura T, Saito K, Hirano Y, Kanayama Y, Miyake H, Asai N, Funahashi K, Hirabara S, Hanabayashi M, Asai S, Ishiguro N.

    Mod Rheumatol.     page: Epub ahead of print   2014.9

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  35. Clinical efficacy of abatacept, tocilizumab, and etanercept in Japanese rheumatoid arthritis patients with inadequate response to anti-TNF monoclonal antibodies. Reviewed

    Hirabara S, Takahashi N, Fukaya N, Miyake H, Yabe Y, Kaneko A, Ito T, Oguchi T, Kida D, Hirano Y, Fujibayashi T, Sugiura F, Hayashi M, Funahashi K, Hanabayashi M, Asai S, Ishiguro N, Kojima T.

    Clin Rheumatol.   Vol. 33 ( 9 ) page: 1247-54   2014.9

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  36. Importance of methotrexate therapy concomitant with tocilizumab treatment in achieving better clinical outcomes for rheumatoid arthritis patients with high disease activity: an observational cohort study. Reviewed

    Kojima T, Yabe Y, Kaneko A, Takahashi N, Funahashi K, Kato D, Hanabayashi M, Asai S, Hirabara S, Asai N, Hirano Y, Hayashi M, Miyake H, Kojima M, Ishiguro N.

    Rheumatology (Oxford).     page: Epub ahead of print   2014.8

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  37. Longterm retention rate and risk factor for discontinuation due to insufficient efficacy and adverse events in Japanese patients with rheumatoid arthritis receiving etanercept therapy. Reviewed

    Matsubara H, Kojima T, Kaneko A, Hirano Y, Ishikawa H, Hattori Y, Miyake H, Oguchi T, Takagi H, Yabe Y, Kato T, Ito T, Fukaya N, Kanayama Y, Shioura T, Hayashi M, Fujibayashi T, Takahashi N, Funahashi K, Kato D, Hanabayashi M, Terabe K, Ishiguro N.

    J Rheumatol.   Vol. 41 ( 8 ) page: 1583-9   2014.8

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  38. (特集)人工関節の有用性と問題点【生物学的製剤使用下の人工関節の課題】

    小嶋 俊久

    リウマチ科   Vol. 51 ( 6 ) page: 664-7   2014.6

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  39. Alexithymia, Depression, Inflammation and Pain in Patients with Rheumatoid Reviewed

    Masayo Kojima MD, PhD, Toshihisa Kojima MD, PhD, Sadao Suzuki MD, PhD,Nobunori Takahashi MD, PhD, Koji Funahashi MD, PhD, Daizo Kato MD, Masahiro Hanabayashi MD, Shinya Hirabara MD, PhD, Shuji Asai MD, PhD, and Naoki Ishiguro MD, PhD

    Arthritis Care & Research   Vol. 66 ( 5 ) page: 679-86   2014.5

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  40. 関節リウマチ治療全体での手術の位置づけー今後の手術療法とはー

    小嶋 俊久

    分子リウマチ治療   Vol. 7 ( 2 ) page: 1-4   2014.5

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  41. 特集 関節リウマチ-診断と治療の進歩 整形外科的治療 滑膜切除術、関節形成術

    小嶋 俊久

    CURRENT THERAPY   Vol. 32 ( 5 ) page: 60-64   2014.5

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  42. VI関節リウマチの検査・診断 5.鑑別診断が必要な疾患(9)変形性関節症

    小嶋 俊久

    日本臨床 増刊号 最新関節リウマチ学   Vol. 72 ( 増刊号3 ) page: 335-8   2014.4

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  43. 特集関節破壊のバイオマーカー 関節疾患におけるII型コラーゲン分解産物(C2C)の軟骨破壊マーカーとしての意義

    小嶋 俊久

    Keynote R・A   Vol. 2 ( 2 ) page: 19-21   2014.4

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  44. (特集)手指の変形性関節症【軟骨代謝マーカー:コラーゲンおよびアグリカンを中心に】

    小嶋 俊久

    リウマチ科   Vol. 51 ( 2 ) page: 162-8   2014.2

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  45. リウマチ日常診療においてQOLを患者がiPadで回答する”問診票システム”をFileMakerで構築

    小嶋 俊久

    Innervision 別冊付録ヘルスケアIT活用情報誌Itvision   Vol. 29   page: 38-9   2014.2

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  46. 日常診療へのプラス イグラチモドの使い方

    小嶋 俊久

    リウマチクリニック   Vol. 19   page: 12-3   2014.2

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  47. Journal Club Toll-like receptor 4 in bone marrow-derived cells as well as tissue-resident cells participate in aggravating autoimmune destructive arthritis. ○ Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin:data from CHECK, a cohort study of early osteoarthritis.

    小嶋 俊久

    分子リウマチ治療   Vol. 7 ( 1 ) page: 47   2014.1

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  48. Highlight Series 第2回 Clinical Highlight

    小嶋 俊久

    Keynote R・A   Vol. 2 ( 1 ) page: 42-5   2014.1

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  49. Clinical efficacy of abatacept compared to adalimumab and tocilizumab in rheumatoid arthritis patients with high disease activity. Reviewed

    Clin Rheumatol.   Vol. 33 ( 1 ) page: 39-47   2014.1

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  50. (整形トピックス)関節疾患におけるII型コラーゲン分解産物による軟骨破壊モニターの意義

    小嶋俊久

    整形外科   Vol. 64 ( 12 ) page: 1284   2013.11

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  51. Monitoring C-reactive protein levels to predict favourable clinical outcomes from tocilizumab treatment in patients with rheumatoid arthritis. Reviewed

    Toshihisa Kojima, Yuichiro Yabe, Atsushi Kaneko, Yuji Hirano, Hisato Ishikawa, Masatoshi Hayashi, Hiroyuki Miyake, Hideki Takagi, Takefumi Kato, Kenya Terabe, Tsuyoshi Wanatabe, Hiroki Tsuchiya, Daihei Kida, Tomone Shioura, Koji Funahashi, Daizo Kato, Hiroyuki Matsubara, Nobunori Takahashi, Yosuke Hattori, Nobuyuki Asai, and Naoki Ishiguro

    Mod Rheumatol.   Vol. 23 ( 5 ) page: 977-85   2013.9

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  52. Twenty-four-week clinical results of adalimumab therapy in Japanese patients with rheumatoid arthritis: retrospective analysis for the best use of adalimumab in daily practice. Reviewed

    Kaneko A, Hirano Y, Fujibayashi T, Hattori Y, Terabe K, Kojima T, Ishiguro N.

    Mod Rheumatol.   Vol. 23 ( 3 ) page: 466-77   2013.9

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  53. No increased mortality in patients with rheumatoid arthritis treated with biologics: results from the biologics register of six rheumatology institutes in Japan. Reviewed

    Nakajima A, Saito K, Kojima T, Amano K, Yoshio T, Fukuda W, Inoue E, Taniguchi A, Momohara S, Minota S, Takeuchi T, Ishiguro N, Tanaka Y, Yamanaka H.

    Mod Rheumatol.   Vol. 23 ( 5 ) page: 945-52   2013.9

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  54. A Fatal Case of Relapsing Pneumonia Caused by Legionella pneumophila in a Patient with Rheumatoid Arthritis After Two Injections of Adalimumub. Reviewed

    Hayashi M, Kuraishi H, Masubuchi T, Furihata K, Aida Y, Kobayakawa T, Deguchi M, Kojima T, Ishiguro N, Kanamono T.

    Clin Clin Med Insights Case Rep.   Vol. 6   page: 101-6   2013.6

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  55. 特集【TNFα阻害薬の10年】関節手術を減らすことができたか

    小嶋俊久

    分子リウマチ治療   Vol. 6 ( 3 ) page: 19-21   2013.6

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  56. (最新基礎科学)【知っておきたい】JAK阻害剤トファシチニブ(tofacitinib)

    小嶋俊久

    臨床整形外科   Vol. 48 ( 6 ) page: 564-569   2013.6

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  57. Relationship between pre-radiographic cartilage damage following anterior cruciate ligament injury and biomarkers of cartilage turnover in clinical practice: a cross-sectional observational study. Reviewed

    Yoshida H, Kojima T, Kurokouchi K, Takahashi S, Hanamura H, Kojima M, Poole AR, Ishiguro N

    Osteoarthritis Cartilage.   Vol. 21 ( 6 ) page: 831-8   2013.6

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  58. Hyaluronan inhibits TLR-4 dependent cathepsin K and matrix metalloproteinase 1 expression in human fibroblasts. Reviewed

    Hirabara S, Kojima T, Takahashi N, Hanabayashi M, Ishiguro N.

    Biochem Biophys Res Commun.   Vol. 430 ( 2 ) page: 519-22   2013.1

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  59. (特集)関節リウマチ治療における生物学的製剤治療-薬剤中止寛解の可能性を中心に-【バイオフリー寛解がいいのか、長期継続がいいのか-現在の治療成績から考える-】

    小嶋俊久、石黒直樹

    リウマチ科   Vol. 48 ( 6 ) page: 664-668   2012.12

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  60. 特集:最新の疾患バイオマーカー研究 II.疾患バイオマーカーの基礎研究 その他の疾患バイオマーカーの基礎研究 骨関節疾患

    小嶋俊久、石黒直樹

    日本臨床   Vol. 70 ( 5 ) page: 796-801   2012.5

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  61. A selective estrogen receptor modulator inhibits tumor necrosis factor-α-induced apoptosis through the ERK1/2 signaling pathway in human chondrocytes. Reviewed

    Hattori Y, Kojima T, Kato D, Matsubara H, Takigawa M, Ishiguro N.

    Biochem Biophys Res Commun.   Vol. 421 ( 3 ) page: 418-24   2012.5

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  62. (特集)RAの新分類基準の時代におけるリウマチ性疾患の鑑別【変形性関節症と高齢発症RAの鑑別】

    小嶋俊久

    リウマチ科   Vol. 47 ( 4 ) page: 324-27   2012.4

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  63. A review of tocilizumab treatment in 122 rheumatoid arthritis patients included in the Tsurumai Biologics Communication Registry (TBCR) Study. Reviewed

    Yabe Y, Kojima T, Kaneko A, Asai N, Kobayakawa T, Ishiguro N.

    Mod Rheumatol.   Vol. 23 ( 2 ) page: 245-53   2012.4

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  64. Pneumococcal polyarticular septic arthritis after a single infusion of infliximab in a rheumatoid arthritis patient: a case report. Reviewed

    Hayashi M, Kojima T, Funahashi K, Kato D, Matsubara H, Shioura T, Kanayama Y, Hirano Y, Deguchi M, Kanamono T, Ishiguro N.

    J Med Case Reports.   Vol. 6 ( 1 ) page: 81   2012.3

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  65. (連載)X線診断Q&A

    小嶋俊久

    整形外科   Vol. 63 ( 2 ) page: 159-60   2012.2

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  66. Pneumocystis jirovecii pneumonia associated with etanercept treatment in patients with rheumatoid arthritis: a retrospective review of 15 cases and analysis of risk factors. Reviewed

    Tanaka M, Sakai R, Koike R, Komano Y, Nanki T, Sakai F, Sugiyama H, Matsushima H, Kojima T, Ohta S, Ishibe Y, Sawabe T, Ota Y, Ohishi K, Miyazato H, Nonomura Y, Saito K, Tanaka Y, Nagasawa H, Takeuchi T, Nakajima A, Ohtsubo H, Onishi M, Goto Y, Dobashi H, Miyasaka N, Harigai M.

    Mod Rheumatol.   Vol. 22 ( 6 ) page: 849-858   2012.2

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  67. Twenty-four-week clinical results of adalimumab therapy in Japanese patients with rheumatoid arthritis: retrospective analysis for the best use of adalimumab in daily practice. Reviewed

    Kaneko A, Hirano Y, Fujibayashi T, Hattori Y, Terabe K, Kojima T, Ishiguro N.

    Mod Rheumatol.     page: ahead of print   2012

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  68. Monitoring C-reactive protein levels to predict favourable clinical outcomes from tocilizumab treatment in patients with rheumatoid arthritis. Reviewed

    Toshihisa Kojima, Yuichiro Yabe, Atsushi Kaneko, Yuji Hirano, Hisato Ishikawa, Masatoshi Hayashi, Hiroyuki Miyake, Hideki Takagi, Takefumi Kato, Kenya Terabe, Tsuyoshi Wanatabe, Hiroki Tsuchiya, Daihei Kida, Tomone Shioura, Koji Funahashi, Daizo Kato, Hiroyuki Matsubara, Nobunori Takahashi, Yosuke Hattori, Nobuyuki Asai, and Naoki Ishiguro

    Mod Rheumatol.     page: in press   2012

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  69. No increased mortality in patients with rheumatoid arthritis treated with biologics: results from the biologics register of six rheumatology institutes in Japan. Reviewed

    Nakajima A, Saito K, Kojima T, Amano K, Yoshio T, Fukuda W, Inoue E, Taniguchi A, Momohara S, Minota S, Takeuchi T, Ishiguro N, Tanaka Y, Yamanaka H.

    Mod Rheumatol.     page: in press   2012

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  70. Clinical efficacy of abatacept in Japanese rheumatoid arthritis patients. Reviewed

    Takahashi N, Kojima T, Terabe K, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Fukaya N, Ishikawa H, Hayashi M, Tsuboi S, Kato D, Funahashi K, Matsubara H, Hattori Y, Hanabayashi M, Hirabara S, Yoshioka Y, Ishiguro N.

    Mod Rheumatol.     page: ahead of print   2012

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  71. Anti-tumour necrosis factor therapy in rheumatoid arthritis patients with a history of deep prosthetic joint infection: a report of four cases. Reviewed

    Hirano Y, Kojima T, Kanayama Y, Shioura T, Hayashi M, Tsuboi S, Ishiguro N

    Mod Rheumatol.   Vol. 21 ( 5 ) page: 542-7   2011.10

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  72. 肩関節周囲炎とRAの肩関節炎の鑑別法法を教えてください〜高齢発症、大関節症状主体のRAの診断について

    小嶋俊久、石黒直樹

    Frontiers in Rheumatology & Clinical Immunology   Vol. 5 ( 2 ) page: 2011-2015   2011

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  73. Keratan sulfate and related murine glycosylation can suppress murine cartilage damage in vitro and in vivo. Reviewed

    Hayashi M, Kadomatsu K, Kojima T, Ishiguro N.

    Biochem Biophys Res Commun     page: ahead of print   2011

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  74. 手術治療周術期に関するTNF阻害薬使用のガイドライン

    小嶋俊久

    分子リウマチ治療   Vol. 4 ( 2 ) page: 31-34   2011

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  75. 関節リウマチと炎症性疾患―診断と治療のゴール

    小嶋俊久

    Orthopaedics   Vol. 24 ( 5 ) page: 111-118   2011

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  76. Early aggressive intervention with tocilizumab for rheumatoid arthritis increases remission rate defined using a Boolean approach in clinical practice. Reviewed

    Toshihisa Kojima,Atsushi Kaneko,Yuji Hirano,Hisato Ishikawa,Hiroyuki Miyake,Hideki Takagi,Yuichiro Yabe,Takefumi Kato,Kenya Terabe,Naoki Fukaya,Hiroki Tsuchiya,Tomone Shioura,Koji Funahashi,Masatoshi Hayashi,Daizo Kato,Hiroyuki Matsubara,Naoki Ishiguro

    Mod Rheumatol.     page: ahead of print   2011

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  77. Effect of total arthroplasty combined with anti-tumor necrosis factor agents in attenuating systemic disease activity in patients with rheumatoid arthritis. Reviewed

    Masatoshi Hayashi,Toshihisa Kojima,Koji Funahashi,Daizo Kato,Hiroyuki Matsubara,Tomone Shioura,Yasuhide Kanayama,Yuji Hirano,Naoki Ishiguro

    Mod Rheumatol.     page: ahead of print   2011

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  78. Study protocol of a multicenter registry of patients with rheumatoid arthritis starting biologic therapy in Japan:Tsurumai Biologics Communication Registry (TBCR) Study. Reviewed

    Toshihisa Kojima,Atsushi Kaneko,Yuji Hirano,Hisato Ishikawa,Hiroyuki Miyake,Takeshi Oguchi,Hideki Takagi,Yuichiro Yabe,Takefumi Kato,Takayasu Ito,Kenya Terabe,Naoki Fukaya,Yasuhide Kanayama,Tomone Shioura,Koji Funahashi,Masatoshi Hayashi,Daizo Kato,Hiroyuki Matsubara,Takayoshi Fujibayashi,Masayo Kojima,Naoki Ishiguro;for the TBC

    Mod Rheumatol.     page: ahead of print   2011

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  79. 最新の関節リウマチ治療の考え方ー早期診断と寛解を目指す治療ー

    小嶋俊久、石黒直樹

    現代醫學   Vol. 58 ( 2 ) page: 277-284   2010.12

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  80. Influences of anti-tumour necrosis factor agents on postoperative recovery in patients with rheumatoid arthritis. Reviewed

    Hirano Y, Kojima T, Kanayama Y, et al.

    Clin Rheumatol.   Vol. 29 ( 5 ) page: 495-500   2010

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  81. Radiographic progression of cervical lesions in patients with rheumatoid arthritis receiving infliximab treatment. Reviewed

    Kanayama Y, Kojima T, Hirano Y, et al.

    Mod Rheumatol.   Vol. 20 ( 3 ) page: 273-279   2010

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  82. Exploring the link between depression and rheumatoid arthritis: prospects for optimal therapeutic success. Reviewed

    Kojima M, Kojima T, Ishiguro N, Furukawa T.

    Int. J. Clin. Rheumatol.   Vol. 5   page: 273-275   2010

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  83. A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab Reviewed

    Sugiura F, Kojima T, Oguchi T, Urata S, Yuzawa Y, Sakakibara A, Hayashi H, Ishiguro N

    Modern Rheumatology   Vol. 19 ( 3 ) page: 323-328   2009

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  84. *Depression, inflammation, and pain in patients with rheumatoid arthritis. Reviewed

    Kojima M, Kojima T, Suzuki S, Oguchi T, Oba M, Tsuchiya H, et al

    Arthritis Rheum   Vol. 61   page: 1018-1024   2009

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  85. *Psychosocial factors, disease status, and quality of life in patients with rheumatoid arthritis Reviewed

    Kojima M, Kojima T, Suzuki S, Oguchi T, Oba M, Tsuchiya H, et al

    J Psychosom Res   Vol. 67 ( 5 ) page: 425-431   2009

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  86. *Roles of metalloproteinase-3 and aggrecanase1 nd 2 in aggrecn cleavage during human meniscus degeneration Reviewed

    Ishihara G, Kojima T, Saito Y, Ishiguro N

    Orthopedic Reviews   Vol. 1   page: e14-16   2009

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  87. *Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model. Reviewed

    Fujibayashi T, Hashimoto N, Jijiwa M, Hasegawa Y, Kojima T

    BMC Pulm Med   Vol. 9   page: 45   2009

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  88. A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab. Reviewed

    Sugiura F, Kojima T, Oguchi T, Urata S, Yuzawa Y, Sakakibara A, et al.

    Modern Rheumatology   Vol. 19   page: 199-203   2009

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  89. 整形外科での生物学的製剤の使い分け Reviewed

    小嶋俊久、石黒直樹

    Monthly Book Orthopaedics   Vol. 22   page: 47-52   2009

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  90. 生物学的製剤と人工関節感染 Reviewed

    小嶋俊久、石黒直樹

    整形外科   Vol. 60   page: 869-873   2009

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  91. 生物学的製剤をどう使い分けるか?整形外科医の視点から Reviewed

    小嶋俊久、石黒直樹

    分子リウマチ治療   Vol. 2   page: 58-62   2009

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  92. 関節破壊進行例に対して Reviewed

    小嶋俊久

    分子リウマチ治療   Vol. 2   page: 37-39   2009

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  93. 特集「変形性膝関節症の基礎と臨床」 3.変形性膝関節症の臨床的病態 Reviewed

    小嶋俊久、石黒直樹

    THE BONE   Vol. 23   page: 51-54   2009

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  94. 関節リウマチ患者の呼吸器に関する調査 Reviewed

    平野裕司、小嶋俊久、金山康秀、石川尚人、石黒直樹

    中部リウマチ   Vol. 39   page: 84-85   2008

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  95. 関節の構造と機能 Reviewed

    小嶋俊久、石黒直樹

    CLINICIAN   Vol. 572   page: 12-16   2008

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  96. 特集:変形性関節症の最新知見 OAの診断 2)OAに対するbiomarkerの有用性:軟骨代謝マーカー:コラーゲン代謝を中心に Reviewed

    小嶋俊久、石黒直樹

    Osteoarthritis Update   Vol. 1   page: 22-25   2008

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  97. 関節リウマチ治療の新展開 Reviewed

    石黒直樹、小嶋俊久、杉浦文昭、土屋廣起、石川尚人

    日整会誌   Vol. 82   page: 224-229   2008

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  98. Infliximab投与症例におけるRA頸椎病変についての検討 Reviewed

    金山康秀、小嶋俊久、平野裕司、石川尚人、石黒直樹

    中部リウマチ   Vol. 39   page: 84-85   2008

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  99. リウマチ関連項目の有用性評価(第2報) 生物学的製剤投与下のリウマチ関連項目の動態について Reviewed

    牧邨舞、松本祐之、安藤善孝、森下芳孝、浅井正樹、高松純樹、小嶋俊久、石黒直樹

    医学検査   Vol. 57   page: 177-181   2008

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  100. Correlation between parathyroid hormone, bone alkaline phosphatase, and N-telopeptide of type I collagen in diabetic and non-diabetic haemodialysis patients Reviewed

    Takahashi N, Kojima T, Ogawa H, Ishiguro, N

    Nephrology   Vol. 12   page: 539-545   2007

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  101. *Influences of menopause, aging, and gender on the cleavage of type II collagen in cartilage in relationship to bone turnover. Reviewed

    Kojima T, Kojima M, Noda K, Ishiguro N, Poole AR.

    Menopause   Vol. 15   page: 133-137   2007

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  102. インフリキシマブ投与時のバイタルサインとクリニカル・パス Reviewed

    平野裕司、小嶋俊久、金山康秀、石川尚人、石黒直樹

    骨・関節・靱帯   Vol. 20   page: 673-681   2007

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  103. リウマチ性疾患における軟骨破壊 Reviewed

    小嶋俊久、石黒直樹

    臨牀と研究   Vol. 84   page: 1410-1416   2007

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  104. 軟骨代謝マーカーによる関節疾患の評価:コラーゲン代謝を中心に Reviewed

    小嶋俊久、石黒直樹

    分子リウマチ   Vol. 4   page: 91-96   2007

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  105. 軟骨代謝マーカー:コラーゲン代謝を中心に

    小嶋俊久

      Vol. 16   page: 126-131   2006

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  106. 当院でのインフリキシマブ使用経験

    杉浦文昭、小嶋俊久、大場満成、土屋廣起、石黒直樹

    中部リウマチ   Vol. 37   page: 18-19   2006

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  107. Anaphylactic reaction to infliximab in two rheumatoid arthritis patients who had previously received infliximab and resumed Reviewed

    Sugiura F, Kojima T, Oba M, Tsuchiya H, Ishiguro N

    Mod Rheumatol   Vol. 15 ( 3 ) page: 201-203   2005.1

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  108. 最新の薬物療法について-新規リウマチ治療薬の開発:新しい生物学的製剤

    小嶋俊久

    現代医学   Vol. 53   page: 215-220   2005

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  109. 関節リウマチ治療における医療連携

    小嶋俊久、 石黒直樹

    実験医療   Vol. 677   page: 19-26   2005

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  110. 変形性関節症における関節軟骨の変性

    石黒直樹、小嶋俊久

    関節外科   Vol. 23   page: 19-24   2004

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  111. Proteolysis of the collagen fibril in osteoarthritis Reviewed

    Poole AR, Nelson F, Dahlberg L, Tchetina E, Kobayashi M, Yasuda T, Squires G, Kojima T, Wu w, Billinghurst RC

    Biochem Soc Symp   Vol. 70   page: 115-123   2003

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  112. 軟骨の細胞生物学と病態

    石黒直樹、小嶋俊久

      Vol. 21   page: 39-43   2003

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  113. Mechanism of cartilage destruction in osteoarthritis Reviewed

    Ishiguro N, Kojima T, Poole AR

    Nagoya J Med Sci   Vol. 65   page: 73-84   2002

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  114. TypeⅡ collagen degradation and its regulation in articular cartilage in osteoarthritis Reviewed

    Poole AR, Kobayashi M, Yasuda T, Laverty S, Mwale F, Kojima T, T Sakai, C Wahl S El-Maadawy, G Webb, Tchetina, W Wu

    Ann Rheum Dis   Vol. 61 Suppl 2   page: ⅱ78-81   2002

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▼display all

Books 9

  1. 特集○×クイズで学んじゃおう!こんなに変わった関節リウマチ最新知識5「薬物治療の○×クイズ5」

    小嶋俊久( Role: Sole author)

    メディカ出版  2016.9 

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    Language:Japanese

  2. 高齢者RAにおいては,治療が困難であることと早期の関節破壊という前提をまず認識することが大事です。

    小嶋俊久( Role: Sole author)

    メディカルレビュー社  2016.6 

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    Language:Japanese

  3. 特集プライマリケア医もできる!関節リウマチ診療<関節リウマチ治療各論-エビデンスも踏まえて>進歩した薬物療法下における手術治療のタイミング:四肢関節から頸椎病変も含めて

    小嶋俊久( Role: Sole author)

    南江堂  2016.5 

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    Language:Japanese

  4. 関節リウマチ治療実践バイブル「I 押さえておくべき基本知識 6. 関節の構造と機能」

    小嶋俊久、石黒直樹( Role: Joint author)

    南江堂  2013 

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    Language:Japanese

  5. 関節リウマチ治療実践バイブル「Ⅶ ケースから学ぶ上手な薬物療法 3. etanerceptが効果的であったケース〔ケース1/ケース2/ケース3〕」

    小嶋俊久( Role: Sole author)

    南江堂  2013 

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    Language:Japanese

  6. リウマチ科「(特集)RAの新分類基準の時代におけるリウマチ性疾患の鑑別【変形性関節症と高齢発症RAの鑑別】」

    小嶋俊久、石黒直樹( Role: Joint author)

    医薬ジャーナル社  2012.5 

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    Language:Japanese

  7. 最新関節リウマチ治療:生物学的製剤の使い方と注意点

    小嶋俊久、石黒直樹( Role: Joint author)

    メジカルビュー社  2007 

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    Language:Japanese

    (生物学的製剤による治療法 副作用と対処法)

  8. 最新関節リウマチ治療:生物学的製剤の使い方と注意点

    小嶋俊久、石黒直樹( Role: Joint author)

    メジカルビュー社  2007 

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    Language:Japanese

    (生物学的製剤 メリット、デメリット)

  9. 最新関節リウマチ治療:生物学的製剤の使い方と注意点

    石黒直樹、小嶋俊久( Role: Joint author)

    メジカルビュー社  2007 

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    Language:Japanese

    (生物学的製剤 作用メカニズム)

▼display all

MISC 22

  1. Association between chest computed tomography findings and respiratory adverse events in rheumatoid arthritis patients undergoing long-term biological therapy. Reviewed

    Matsumoto T, Iwano S, Takahashi N, Asai S, Watanabe T, Asai N, Sobue Y, Ito S, Ishiguro N, Kojima T

    International journal of rheumatic diseases     2018.11

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    Language:English  

    DOI: 10.1111/1756-185X.13434

    PubMed

  2. Target setting for lower limb joint surgery using the Timed Up and Go test in patients with rheumatoid arthritis: A prospective cohort study. Reviewed

    Kojima T, Ishikawa H, Tanaka S, Haga N, Nishida K, Yukioka M, Hashimoto J, Miyahara H, Niki Y, Kimura T, Oda H, Asai S, Funahashi K, Kojima M, Ishiguro N

    International journal of rheumatic diseases   Vol. 21 ( 10 ) page: 1801-1808   2018.10

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    Language:English  

    DOI: 10.1111/1756-185X.13394

    PubMed

  3. Clinical effectiveness and long-term retention of abatacept in elderly rheumatoid arthritis patients: Results from a multicenter registry system. Reviewed

    Takahashi N, Kojima T, Kida D, Kaneko A, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Hanabayashi M, Kato T, Funahashi K, Hayashi M, Tsuboi S, Kanayama Y, Sobue Y, Asai N, Matsumoto T, Watanabe T, Asai S, Ishiguro N

    Modern rheumatology     page: 1-23   2018.9

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    Language:English  

    DOI: 10.1080/14397595.2018.1525019

    PubMed

  4. Effect of subcutaneous tocilizumab treatment on work/housework status in biologic-naïve rheumatoid arthritis patients using inverse probability of treatment weighting: FIRST ACT-SC study. Reviewed

      Vol. 20 ( 1 ) page: 151   2018.7

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    Language:English  

    DOI: 10.1186/s13075-018-1647-3

    PubMed

  5. Overall benefits provided by orthopedic surgical intervention in patients with rheumatoid arthritis. Reviewed

    Ishikawa H, Abe A, Kojima T, Kojima M, Ishiguro N, Nomura Y, Otani H, Hasegawa E, Kobayashi D, Ito S, Nakazono K, Murasawa A

    Modern rheumatology     page: 1-9   2018.4

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    Language:English  

    DOI: 10.1080/14397595.2018.1457468

    PubMed

  6. High rate of improvement in serum matrix metalloproteinase-3 levels at 4 weeks predicts remission at 52 weeks in RA patients treated with adalimumab. Reviewed

    Hattori Y, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Oguchi T, Kanayama Y, Miyake H, Kato T, Takagi H, Hayashi M, Ito T, Shioura T, Takahashi N, Ishikawa H, Funahashi K, Ishiguro N

    Modern rheumatology   Vol. 28 ( 1 ) page: 119-125   2018.1

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    Language:English  

    DOI: 10.1080/14397595.2017.1317320

    PubMed

  7. Patient-reported outcomes as assessment tools and predictors of long-term prognosis: a 7-year follow-up study of patients with rheumatoid arthritis.

    Kojima M, Kojima T, Suzuki S, Takahashi N, Funahashi K, Asai S, Yoshioka Y, Terabe K, Asai N, Takemoto T, Ishiguro N

    International journal of rheumatic diseases   Vol. 20 ( 9 ) page: 1193-1200   2017.9

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    Language:English  

    DOI: 10.1111/1756-185X.12789

    PubMed

  8. Absence of a relationship between joint space narrowing and osteophyte formation in early knee osteoarthritis among Japanese community-dwelling elderly individuals: A cross-sectional study. Reviewed

    Komatsu D, Hasegawa Y, Kojima T, Seki T, Higuchi Y, Ishiguro N

    Modern rheumatology   Vol. 27 ( 4 ) page: 675-682   2017.7

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    Language:English  

    DOI: 10.1080/14397595.2016.1232775

    PubMed

  9. Improved diagnosis of common bile duct stone with single-shot balanced turbo field-echo sequence in MRCP. Reviewed

    Noda Y, Goshima S, Kojima T, Kawaguchi S, Kawada H, Kawai N, Koyasu H, Matsuo M, Bae KT

    Abdominal radiology (New York)   Vol. 42 ( 4 ) page: 1183-1188   2017.4

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    Language:English  

    DOI: 10.1007/s00261-016-0990-6

    PubMed

  10. Red degeneration of a uterine fibroid following the administration of gonadotropin releasing hormone agonists. Reviewed

    Hachiya K, Kato H, Kawaguchi S, Kojima T, Nishikawa Y, Fujiwara S, Matsuo M

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology   Vol. 36 ( 8 ) page: 1018-1019   2016.11

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    Language:English  

    DOI: 10.1080/01443615.2016.1234449

    PubMed

  11. Mechanical stress loading induces CD44 cleavage in human chondrocytic HCS-2/8 cells. Reviewed

    Kobayakawa T, Takahashi N, Sobue Y, Terabe K, Ishiguro N, Kojima T

    Biochemical and biophysical research communications   Vol. 478 ( 3 ) page: 1230-5   2016.9

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    Language:English  

    DOI: 10.1016/j.bbrc.2016.08.099

    PubMed

  12. Validity of radiographic assessment of the knee joint space using automatic image analysis.

    Komatsu D, Hasegawa Y, Kojima T, Seki T, Ikeuchi K, Takegami Y, Amano T, Higuchi Y, Kasai T, Ishiguro N

    Modern rheumatology   Vol. 26 ( 5 ) page: 761-6   2016.9

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    DOI: 10.3109/14397595.2015.1130679

    PubMed

  13. Simvastatin inhibits CD44 fragmentation in chondrocytes. Reviewed

    Terabe K, Takahashi N, Takemoto T, Knudson W, Ishiguro N, Kojima T

    Archives of biochemistry and biophysics   Vol. 604   page: 1-10   2016.8

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    Language:English  

    DOI: 10.1016/j.abb.2016.05.019

    PubMed

  14. Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study. Reviewed

    Hattori Y, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Terabe K, Yabe Y, Miyake H, Kato T, Takagi H, Hayashi M, Ito T, Kanayama Y, Oguchi T, Takahashi N, Ishikawa H, Funahashi K, Ishiguro N

    The Journal of rheumatology   Vol. 43 ( 8 ) page: 1475-9   2016.8

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    Language:English  

    DOI: 10.3899/jrheum.151006

    PubMed

  15. Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages. Reviewed

    Matsumoto T, Takahashi N, Kojima T, Yoshioka Y, Ishikawa J, Furukawa K, Ono K, Sawada M, Ishiguro N, Yamamoto A

    Arthritis research & therapy   Vol. 18 ( 1 ) page: 133   2016.6

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    Language:English  

    DOI: 10.1186/s13075-016-1035-9

    PubMed

  16. Usefulness of T2*-weighted MRI in the detection of adnexal torsion. Reviewed

    Kawai N, Kato H, Kanematsu M, Kawaguchi S, Kojima T, Furui T, Morishige K, Matsuo M

    Acta radiologica open   Vol. 5 ( 6 ) page: 2058460116645375   2016.6

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    DOI: 10.1177/2058460116645375

    PubMed

  17. Improved safety of biologic therapy for rheumatoid arthritis over the 8-year period since implementation in Japan: long-term results from a multicenter observational cohort study.

    Kojima T, Takahashi N, Funahashi K, Asai S, Terabe K, Kaneko A, Hirano Y, Hayashi M, Miyake H, Oguchi T, Takagi H, Kanayama Y, Yabe Y, Watanabe T, Fujibayashi T, Shioura T, Ito T, Yoshioka Y, Ishikawa H, Asai N, Takemoto T, Kojima M, Ishiguro N

    Clinical rheumatology   Vol. 35 ( 4 ) page: 863-71   2016.4

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    Language:English  

    DOI: 10.1007/s10067-016-3201-5

    PubMed

  18. Predictive factors for achieving low disease activity at 52 weeks after switching from tumor necrosis factor inhibitors to abatacept: results from a multicenter observational cohort study of Japanese patients.

    Kojima T, Takahashi N, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Watanabe T, Hayashi M, Shioura T, Kanayama Y, Funahashi K, Asai S, Yoshioka Y, Terabe K, Takemoto T, Asai N, Ishiguro N

    Clinical rheumatology   Vol. 35 ( 1 ) page: 219-25   2016.1

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    Language:English  

    DOI: 10.1007/s10067-015-3135-3

    PubMed

  19. The process of collecting and evaluating evidences for the development of Guidelines for the management of rheumatoid arthritis, Japan College of Rheumatology 2014: Utilization of GRADE approach.

    Kojima M, Nakayama T, Kawahito Y, Kaneko Y, Kishimoto M, Hirata S, Seto Y, Endo H, Ito H, Kojima T, Nishida K, Matsushita I, Tsutani K, Igarashi A, Kamatani N, Hasegawa M, Miyasaka N, Yamanaka H

    Modern rheumatology   Vol. 26 ( 2 ) page: 175-9   2016

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    DOI: 10.3109/14397595.2015.1069474

    PubMed

  20. Disease activity early in treatment as a predictor of future low disease activity in RA patients treated with iguratimod.

    Yoshioka Y, Takahashi N, Kaneko A, Hirano Y, Kanayama Y, Kanda H, Takagi H, Ito T, Kato T, Saito K, Funahashi K, Asai S, Takemoto T, Terabe K, Asai N, Ishiguro N, Kojima T

    Modern rheumatology   Vol. 26 ( 2 ) page: 169-74   2016

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    Language:English  

    DOI: 10.3109/14397595.2015.1069475

    PubMed

  21. Respiratory mechanics measured by forced oscillation technique in rheumatoid arthritis-related pulmonary abnormalities: frequency-dependence, heterogeneity and effects of smoking.

    Sokai R, Ito S, Iwano S, Uchida A, Aso H, Kondo M, Ishiguro N, Kojima T, Hasegawa Y

    SpringerPlus   Vol. 5   page: 335   2016

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    Language:English  

    DOI: 10.1186/s40064-016-1952-8

    PubMed

  22. Concomitant Methotrexate Protects Against Total Knee Arthroplasty in Patients with Rheumatoid Arthritis Treated with Tumor Necrosis Factor Inhibitors.

    Asai S, Takahashi N, Funahashi K, Yoshioka Y, Takemoto T, Terabe K, Asai N, Ishiguro N, Kojima T

    The Journal of rheumatology   Vol. 42 ( 12 ) page: 2255-60   2015.12

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    Language:English  

    DOI: 10.3899/jrheum.150410

    PubMed

▼display all

Presentations 68

  1. Can we predict future cartilage damage from synovial fluid in anterior cruciate ligament reconstruction? International conference

    Yasumori Sobue, Toshihisa Kojima, Kazutoshi Kurokouchi, Shigeo Takahashi, Naoki Ishiguro

    The Orthopaedic Research Society 2017 Annual Meeting 

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    Event date: 2017.3

    Language:English   Presentation type:Poster presentation  

    Venue:San Diego Convention Center   Country:United States  

  2. ADAM10 inhibitor suppresses CD44 cleavage and chondrogenic dedifferentiation in bovine primary chondrocyte cells International conference

    Yasumori Sobue, Nobunori Takahashi, Naoki Ishiguro, Toshihisa Kojima

    The Orthopaedic Research Society 2017 Annual Meeting 

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    Event date: 2017.3

    Language:English   Presentation type:Poster presentation  

    Venue:San Diego Convention Center   Country:United States  

  3. 軟骨破壊メカニズム

    小嶋俊久,高橋伸典,祖父江康司,渡部達生,鈴木望人,石黒直樹

    第30回日本軟骨代謝学会 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:京都市勧業館みやこめっせ   Country:Japan  

  4. Characteristics of functional impairment in patients with long-standing rheumatoid arthritis based on range of motion of joints: multicenter prospective cohort study for evaluation of joint surgery on physical function International conference

    Toshihisa Kojima, Hajime Ishikawa, Sakae Tanaka, Nobuhiko Haga, Keiichiro Nishida, Masao Yukioka, Jun Hashimoto, Hisaaki Miyahara, Yasuo Niki, Tomoatu Kimura, Hiromi Oda, Masayo Kojima, Naoki Ishiguro

    American College of Rheumatology 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

    Venue:Walter E. Washington Convention Center   Country:United States  

  5. "Validation of index of activity speed (Time Up and Go test) for Outcome measure of patients International conference

    Toshihisa Kojima, Hajime Ishikawa, Sakae Tanaka, Nobuhiko Haga, Keiichiro Nishida, Masao Yukioka, Jun Hashimoto, Hisaaki Miyahara, Yasuo Niki, Tomoatu Kimura, Hiromi Oda, Masayo Kojima, Naoki Ishiguro

    Toshihisa Kojima, Hajime Ishikawa, Sakae Tanaka, Nobuhiko Haga, Keiichiro Nishida, Masao Yukioka, Jun Hashimoto, Hisaaki Miyahara, Yasuo Niki, Tomoatu Kimura, Hiromi Oda, Masayo Kojima, Naoki Ishiguro 

     More details

    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

    Venue:Walter E. Washington Convention Center   Country:United States  

  6. Predictive Value of Chest HRCT Findings for Respiratory Adverse Event among RA Patients Treated with Biological Therapy : Long-Term Results from an Observational Study International conference

    Takuya Matsumoto, Toshihisa Kojima, Nobunori Takahashi, Shuji Asai, Nobuyuki Asai, Tatsuo Watanabe, Yasumori Sobue, Naoki Ishiguro, Shingo Iwano, Satoru Ito

    American College of Rheumatology 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

    Venue:Walter E. Washington Convention Center   Country:United States  

  7. SERO-POSITIVITY FOR RHEUMATOID FACTOR IS AN INDEPENDENT PREDICTOR FOR ACHIEVEMENT OF GOOD EULAR RESPONSE AT 24 WEEKS IN ACPA POSITIVE RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT: RESULTS FROM JAPANESE MULTICENTER REGISTRY International conference

    Nobunori Takahashi, Toshihisa Kojima, Koji Funahashi, Naoki Ishiguro

    American College of Rheumatology 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

    Venue:Walter E. Washington Convention Center   Country:United States  

  8. リウマチ性疾患の疼痛マネージメント

    小嶋俊久

    第31回日本臨床リウマチ学会 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:京王プラザホテル   Country:Japan  

  9. 人工膝関節置換術による治療成績向上のために:可動域と動作速度から考える

    小嶋俊久

    第31回日本臨床リウマチ学会 

     More details

    Event date: 2016.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:京王プラザホテル   Country:Japan  

  10. Predictive Value of Chest HRCT Findings for Respiratory Adverse Event among RA Patients Treated with Biological Therapy : Long-Term Results from an Observational Study International conference

    Takuya Matsumoto, Toshihisa Kojima, Nobunori Takahashi, Shuji Asai, Nobuyuki Asai, Tatsuo Watanabe, Yasumori Sobue, Naoki Ishiguro, Shingo Iwano, Satoru Ito

    8th International Forum on Rheumatoid Arthritis 2016 

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    Event date: 2016.10

    Language:English   Presentation type:Poster presentation  

    Venue:Shinagawa Prince Hotel   Country:Japan  

  11. 名古屋大学医学部附属病院でのリウマチ治療におけるチーム医療

    小嶋俊久

    第28回中部リウマチ学会 日本リウマチ学会中部支部学術集会 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:ザ・グランユアーズフクイ( 旧 ホテルフジタ福井 宴会場 )   Country:Japan  

  12. Retention Rate of Biologic Agents after Remission Induced with and without Concomitant Glucocorticoid Treatment in Patients with Rheumatoid Arthritis: A Propensity Score Matched Analysis International conference

    Shuji Asai, Toshihisa Kojima, Nobunori Takahashi, Koji Funahashi, Naoki Ishiguro and TBCR study group

    The European League Against Rheumatism 

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    Event date: 2016.6

    Language:English   Presentation type:Poster presentation  

    Venue:Congress venue   Country:United Kingdom  

  13. SERO-POSITIVITY FOR RHEUMATOID FACTOR IS AN INDEPENDENT PREDICTOR FOR ACHIEVEMENT OF GOOD EULAR RESPONSE AT 24 WEEKS IN ACPA POSITIVE RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT: RESULTS FROM JAPANESE MULTICENTER REGISTRY International conference

    Nobunori Takahashi, Toshihisa Kojima, Koji Funahashi, Naoki Ishiguro

    The European League Against Rheumatism 

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    Event date: 2016.6

    Language:English   Presentation type:Poster presentation  

    Venue:Congress venue   Country:United Kingdom  

  14. THE VALIDATION ABOUT THE MEASUREMENT OF JOINT SPACE DISTANCE BY USING SUPER RESOLUTION IMAGE AND CURVE FITTING METHODS. International conference

    Koji Funahashi, T. Kojima, N. Takahashi, T. Goto, M. Shimizu, H. Kariya, N. Ishiguro

    The European League Against Rheumatism 

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    Event date: 2016.6

    Language:English   Presentation type:Poster presentation  

    Venue:Congress venue   Country:United Kingdom  

  15. Characteristics of functional impairment in patients with long-standing rheumatoid arthritis based on range of motion of joints: multicenter prospective cohort study for evaluation of joint surgery on physical function International conference

    Toshihisa Kojima, Hajime Ishikawa, Sakae Tanaka, Nobuhiko Haga, Keiichiro Nishida, Masao Yukioka, Jun Hashimoto, Hisaaki Miyahara, Yasuo Niki, Tomoatsu Kimura, Hiromi Oda, Masayo Kojima, Naoki Ishiguro

    The European League Against Rheumatism 

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    Event date: 2016.6

    Language:English   Presentation type:Poster presentation  

    Venue:Congress Venue   Country:United Kingdom  

  16. 現在そして今後のリウマチ治療を考える-生物学的製剤が教えてくれたこと-

    小嶋俊久

    第89回日本整形外科学会学術総会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:パシフィコ横浜及びヨコハマグランドインターコンチネンタルホテル   Country:Japan  

  17. 多関節障害RA患者の下肢機能評価-多施設共同研究手術治療における動作速度 Time Up and Go の数値目標としての意義-

    小嶋俊久,石川肇,西田圭一郎,田中栄,芳賀信彦,橋本淳,宮原寿明,二木康夫,小嶋雅代,石黒直樹

    第89回日本整形外科学会学術総会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜及びヨコハマグランドインターコンチネンタルホテル   Country:Japan  

  18. 周術期における生物学的製剤の使い方-RA手術にいたる患者背景をふまえて-

    小嶋俊久

    第89回日本整形外科学会学術総会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:パシフィコ横浜及びヨコハマグランドインターコンチネンタルホテル   Country:Japan  

  19. Importance of Monitoring of C-Reactive Protein during Treatment in RA Patients with Tocilizumab International conference

    T. Kojima , K. Funahashi , N. Takahashi , D. Kato , H. Matsubara , Y. Hattori, N. Ishiguro and TBCR study group

    eular2012 

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    Event date: 2012.6

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  20. 関節リウマチによる膝関節破壊に対する生物学的製剤の中期(5年)成績

    小嶋俊久、高橋伸典、舟橋康治、加藤大三、松原浩之、石黒直樹

    第85回日本整形外科学会 

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    Event date: 2012.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  21. 早期関節リウマチ診断における変形性関節症との鑑別

    小嶋俊久、高橋伸典、舟橋康治、加藤大三、松原浩之、石黒直樹

    第56回日本リウマチ学会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  22. 関節リウマチのTNFα阻害による効果不十分例におけるAbataceptの有効性Tsurumai Biologics Communication Registry(TBCR)登録例から

    小嶋俊久、高橋伸典、来田大平、金子敦史、平野裕司、林真利、矢部裕一朗、杉浦文昭、三宅洋之、土屋廣起、金山康秀、藤林孝義、渡辺剛、舟橋康治、加藤大三、松原浩之、服部陽介、吉岡裕、石黒直樹

    第56回日本リウマチ学会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  23. 高齢者における生物学的製剤治療の安全性ーTsurumi Biologics Communication Registry(TBCR)登録症例における肺関連有害事象の発生頻度からー

    小嶋俊久、金子敦史、平野裕司、林真利、矢部裕一朗、小口武、三宅洋之、高木英希、藤林孝義、渡辺剛、高橋伸典、舟橋康治、加藤大三、松原浩之、服部陽介、石川尚人、寺部健哉、石黒直樹

    第56回日本リウマチ学会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  24. OA発生要因とII型コラーゲン分解産物の関連

    小嶋俊久、岡敬之、吉村典子、Poole AR、石黒直樹

    第25回日本軟骨代謝学会 

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    Event date: 2012.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  25. Early Aggressive Intervention for Rheumatoid Arthritis Increases Rate of Remission Defined Using a Boolean Approach in Clinical Practice with Tocilizumab International conference

    Toshihisa Kojima

    ACR2011 

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    Event date: 2011.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  26. 関節リウマチ患者における血中II型コラーゲン分解産物の軟骨破壊マーカーとしての意義

    小嶋俊久、林真利、舟橋康治、加藤大三、松原浩之、石黒直樹、J.S.Mort、A.R.Poole

    第26回日本整形外科学会基礎学術集会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  27. 生物学的製剤使用中の有害事象発生の経年的変化―多施設生物学的製剤治療研究(TBC)登録症例から―

    小嶋俊久

    第23回中部リウマチ学会 

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    Event date: 2011.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  28. RA手術周術期での注意点—手術療法のrisk-benefitを考える―

    小嶋俊久、林真利、舟橋康治、加藤大三、松原浩之、石黒直樹

    第55回日本リウマチ学会 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  29. トシリズマブ治療時のCRPのモニタリングの意義―多施設共同研究(TBC)より―

    小嶋俊久、矢部裕一朗、林真利、舟橋康治、加藤大三、松原浩之、小早川知範、斉藤究、塩浦朋根、金子浩史、平野裕司、石黒直樹

    第55回日本リウマチ学会 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  30. 継続率からみた生物学的製剤の治療現状と予後予測—多施設(TBC)登録1481例より―

    小嶋俊久、林真利、舟橋康治、加藤大三、松原浩之、金子浩史、小口武、高木英希、矢部裕一朗、平野裕司、石川尚人、三宅洋之、藤林孝義、加藤武史、石黒直樹

    第55回日本リウマチ学会 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  31. 中高齢者の運動習慣と関節機能、軟骨代謝の関連

    小嶋俊久、岡敬行、吉村典子、Poole AR、石黒直樹

    第24回日本軟骨代謝学会 

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    Event date: 2011.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  32. The role of cathepsin K on IL-1-induced degradation of type II collagen in explants culture of human cartilage with measurement of cathepsin K-generated specific site International conference

    Toshihisa Kojima, Naoki Ishiguro, John S Mort, Anthony R Poole

    2011 Annual Meeting of the Orthopaedic Research Society 

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    Event date: 2011.1

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  33. II型コラーゲン分解におけるカテプシンKの役割ーコラゲナーゼによるII型コラーゲン分解、アグリカンの分解との比較ー

    小嶋俊久、John S. Mort、Anthony R. Poole、石黒直樹

    第25回日本整形外科学会基礎学術集会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  34. 関節リウマチのエタネルセプトによる治療状況ー2つの多施設共同研究からー

    第22回中部リウマチ学会 

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    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  35. Association of the Dysfunction of Upper Limbs with Depression in the Patients with Rheumatoid Arthritis Controlled to Low Disease Activity by Treatmento Using Infliximab Combined with MTX International conference

    eular2010 

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    Event date: 2010.6

    Language:English   Presentation type:Poster presentation  

  36. 人工関節置換術を施行した関節リウマチ患者の治療状況ー全国10000例の横断的疫学調査よりー

    小嶋俊久、荻野昇、森美賀子、石黒直樹、宮坂信之、山中寿、竹内勤、當間重人、山本一彦

    第83回日本整形外科学会 

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    Event date: 2010.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  37. 継続率からみた生物学的製剤治療の現状ー多施設研究グループ1185例からの検討ー

    小嶋俊久、金山康秀、塩浦朋根、林真利、舟橋康治、金子敦史、高木英希、三宅洋之、小口武、平野裕司、石川尚人、矢部裕一朗、石黒直樹

    第54回日本リウマチ学会 

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    Event date: 2010.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  38. カテプシンKによる尿中II型コラーゲン分解産物(C2K)の年齢、性による変化ーコラゲナーゼによる尿中II型コラーゲン分解産物(C2C)、NTxとの比較ー

    小嶋俊久、Mort JS、Poole AR、石黒直樹

    第23回日本軟骨代謝学会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  39. How Can WE Know the Response of Chondrocyte in Articular Cartilage to Pathological and Physiological Stimulation in vivo? ーRole of Clearvage of Type II Collagen by Collagenase in Osteoarthritisー International conference

    BMMP-10, EaST-1 

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    Event date: 2010.1

    Language:English   Presentation type:Oral presentation (general)  

  40. 生物学的製剤使用下の関節リウマチ患者QOLー疾患活動抑制下の抑うつ度と身体的機能評価との関連ー

    小嶋俊久、金山康秀、塩浦朋根、林真利、舟橋康治、石黒直樹

    第24回日本臨床リウマチ学会 

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    Event date: 2009.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  41. Raloxifeneによる骨芽細胞のアポトーシス抑制効果の検討

    第24回日本整形外科学会基礎学術集会 

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    Event date: 2009.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  42. Radiograhic progression of cervical lesions in patients with rheumatoid arthritis receiving infliximab treatment International conference

    73rd American College of Rheumatology Annual Scientific Meeting 

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    Event date: 2009.10

    Language:English   Presentation type:Oral presentation (general)  

  43. 多人工関節置換術施行患者の生命予後

    小嶋俊久 他

    第21回中部リウマチ学会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  44. Relationship between the expression of Toll Like Receptors and Degradation of Matrix in Osteoarthiritic Cartilage International conference

    2009Oeteoarthritis Research Society International 

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    Event date: 2009.9

    Language:English   Presentation type:Oral presentation (general)  

  45. TNFα阻害療法の効果:整形外科の立場から

    小嶋俊久、金山康秀、平野裕司、塩浦朋根、林真利、石黒直樹

    第53回日本リウマチ学会 

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    Event date: 2009.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  46. 関節炎モデルマウスにおけるケラタン硫酸の軟骨破壊抑制効果

    第22回日本軟骨代謝学会 

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    Event date: 2009.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  47. Influences of anti-TNF agents on healing of surgical wounds and postoperative recovery of patients with rheumatoid arthritis International conference

    72nd American College of Rheumatology Annual Scientific Meeting 

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    Event date: 2008.10

    Language:English   Presentation type:Oral presentation (general)  

  48. インフリキシマブ使用例における肺障害とその経過

    小嶋俊久、平野裕司、金山康秀、塩浦朋根、藤林孝義、石黒直樹

    第20回中部リウマチ学会 

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    Event date: 2008.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  49. 手術治療を行った関節リウマチ患者における生活の質、抑うつ度の検討

    小嶋俊久、金山康秀、平野裕司、石川尚人、小嶋雅代、石黒直樹

    第81回日本整形外科学会学術総会 

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    Event date: 2008.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  50. 手術療法を受けた関節リウマチ患者の抑うつ度

    小嶋俊久、金山康秀、平野裕司、石川尚人、石黒直樹

    第52回日本リウマチ学会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  51. 人工関節感染の治療:セメントレス人工股関節による人工関節感染後再置換術を行った関節リウマチの2例

    小嶋俊久

    第19回中部リウマチ学会 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  52. Psychological factors and disease status in rheumatoid arthritis patients International conference

    19th World Congress on Psychosomatic Medicine 

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    Event date: 2007.8

    Language:English   Presentation type:Oral presentation (general)  

  53. Pain, inflammation and psychosocial factors in rheumatoid arthritis patients International conference

    19th World Congress on Psychosomatic Medicine 

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    Event date: 2007.8

    Language:English   Presentation type:Oral presentation (general)  

  54. 関節リウマチ患者における疾患活動性、うつ度、QOL評価と精神医学的治療の意義

    小嶋俊久、金山康秀、石川尚人、高橋伸典、平野裕司、小嶋雅代、石黒直樹

    第80回日本整形外科学会学術総会 

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    Event date: 2007.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  55. 抑うつ度、生活の質から見た関節リウマチ治療における精神医学的アプローチの意義

    小嶋俊久、金山康秀、石川尚人、高橋伸典、平野裕司、石黒直樹

    第51回日本リウマチ学会 

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    Event date: 2007.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  56. Correlation between parathyroid hormone, bone alkaline phosphatase, and N-telopeptide of type I collagen in diabetic patients on regular hemodialysis, compared to non-diabetic patients International conference

    53rd Annual Meeting of the Orthopaedic Research Society 

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    Event date: 2007.2

    Language:English   Presentation type:Oral presentation (general)  

  57. The Role of Urokinase Type Plasminogen Activator-reseptor System on Activation of Matrixmetalloproteinases and Aggrecanases in Osteoarthritic Cartilage International conference

    American College of Rheumatology 2006 

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    Event date: 2006.11

    Language:English   Presentation type:Oral presentation (general)  

  58. 変形性関節症における軟骨変性とTypeⅡ Collagen分解との関連

    小嶋俊久

    第21回日本整形外科学会基礎学術集会 

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    Event date: 2006.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  59. 関節リウマチに対する人口膝関節置換術におけるナビゲーションの有用性

    小嶋俊久、大場満成、土屋廣起、杉浦文昭、石黒直樹

    第50回日本リウマチ学会 

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    Event date: 2006.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  60. Cartilage metabolism in hemodialysis patients International conference

    52 Annual Meeting of Orthopaedic Research Society 

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    Event date: 2006.3

    Language:English   Presentation type:Oral presentation (general)  

  61. Nuclear factor-k decoy inhibits aggrecanase expressions in synovial cells derived from rheumatoid arthritis International conference

    52 Annual Meeting of Orthopaedic Research Society 

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    Event date: 2006.3

    Language:English   Presentation type:Oral presentation (general)  

  62. 関節リウマチにおけるメソトレキセートによる治療効果とⅡ型コラーゲン分解との関連について

    小嶋俊久、金山康秀、大場満成、土屋廣起、杉浦文昭、AR Poole、石黒直樹

    第49回日本リウマチ学会 

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    Event date: 2005.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  63. 過度の運動負荷による骨軟骨破壊:骨代謝、軟骨破壊マーカーによる運動負荷の生体に対する影響の評価

    第19回日本整形外科学会基礎学術集会 

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    Event date: 2004.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  64. Role of clearvage of typeⅡ collagen by collagenase in osteoarthritis International conference

    5 Combined Meeting of Orthopedic Research Societies of the USA, Canada, Japan, and Europe 

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    Event date: 2004.10

    Language:English   Presentation type:Oral presentation (invited, special)  

  65. 関節リウマチ患者の主観的QOL規定要因に関する疫学的検討

    小嶋俊久、小嶋雅代、大場満成、土屋廣起、杉浦文昭、石黒直樹

    第48回日本リウマチ学会 

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    Event date: 2004.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  66. The role of clearvage of typeⅡ collagen by collagenases in cartilage destruction in osteoarthritis International conference

    13 International Rheumatology Symposium 

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    Event date: 2004.4

    Language:English   Presentation type:Oral presentation (general)  

  67. MMP/ADAMTSと軟骨破壊のメカニズム:酵素特異的分解産物による検討

    小嶋俊久、Poole AR、徳留信寛、石黒直樹

    第18回日本整形外科学会基礎学術集会 

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    Event date: 2003.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  68. Changes in Serum Levels of Collagenase-cleaved TypeⅡ Collagen with Disease in Rheumatoid Arthritis International conference

    American College of Rheumatology 2002 

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    Event date: 2002.10

    Language:English   Presentation type:Oral presentation (general)  

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Research Project for Joint Research, Competitive Funding, etc. 6

  1. 関節リウマチに対するトシリズマブ治療におけるメトトレキサート併用中止後の治療効果持続性 に関する研究

    2016.11 - 2018.3

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    IL-6受容体抗体トシリズマブとメトトレキサート併用療法により低疾患活動性を達成した関節リウマチ患者においてメトトレキサートを減量、休薬したときにどれだけ治療効果が維持されるかを検討する

  2. 我が国における関節リウマチ治療の標準化に関する多層的研究

    2014.4 - 2017.3

    科学技術振興調整費 

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    Grant type:Competitive

  3. 多関節障害重症RA患者に対する総合的関節機能再建治療法の検討と治療ガイドライン確立

    2012.4 - 2015.3

    科学技術振興調整費 

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    Grant type:Competitive

  4. 我が国における関節リウマチ治療の標準化に関する多層的研究

    2011.4 - 2014.3

    科学技術振興調整費 

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    Grant type:Competitive

  5. 高齢者の運動器疾患の調査とそれに係る新規長寿医療の開発

    2011.4 - 2012.3

    国内共同研究 

  6. 高齢者(認知症等の疾患等を有するものを含む.)における運動器疾患(骨折,関節疾患)に係る調査研究

    2009.8 - 2011.3

    国内共同研究 

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KAKENHI (Grants-in-Aid for Scientific Research) 9

  1. Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiation

    Grant number:16K10897  2016.4 - 2019.3

    Takahashi Nobunori

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    Authorship:Coinvestigator(s) 

    We mainly demonstrated that the fragment of cleaved CD44 (CD44-ICD) had a function to induce the de-differentiation of articular chondrocytes. We also demonstrated that the cartilage degradation in the conditional knock-out mice (Col2a1-cre; ADAM10) was apparently suppressed compared to that in the wild-type mice. The cleavage of CD44 can result in diminished extracellular matrix because of both decreased functional membranous receptor for hyaluronan and induction of de-differentiation by CD44-ICD.

  2. 関節リウマチに対する抗RANKL抗体と炎症性サイトカイン阻害薬併用療法の治療効果

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  3. Inhibitory effects of combination therapy of denosumab, anti-RANKL antibody, and biological DMARD on bone and cartilage destruction in patients with rheumatoid arthritis

    Grant number:26462290  2014.4 - 2017.3

    Kojima Toshihisa

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    Authorship:Principal investigator 

    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    The purpose of this research project was to focus on the effect of antibody Denosumab on RANKL, which is particularly deeply related to bone resorption, and to elucidate the bone metabolism in rheumatoid arthritis (RA) and factors related to 1). The observation study of patients with Denosumab (TBCR-Bone), and 2). the specimen collection and analysis from RA surgical patients were encouraged. 1) About 76 registered RA patients were verified under real clinical practice up to 12 months, improved bone density, and suppression of bone metabolic markers were confirmed. The effects of disease activity were suggested. Ra-Bio, the steroid administration had no effect on Denosumab's effects. 2), bone cartilage collected during surgery from 25 patients, immunostaining and pathological evaluation of synovial membranes was performed.

  4. Transient receptor potential vanilloid 4 (TRPV4) plays a pivotal role in chondrogenic mechanotransduction in ATDC5 cells

    Grant number:26670660  2014.4 - 2016.3

    Naoki Ishiguro

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    Authorship:Coinvestigator(s) 

    The study aimed to determine the role of transient receptor potential vanilloid 4 (TRPV4) in the response to mechanical stress in chondrogenic cells. Sox9 and AGC mRNA levels were significantly higher in cells after mechanical stress loading compared to cells that were not stretched. Up-regulation of Sox9 mRNA induced by mechanical stress was attenuated by RR and TRPV4 siRNA. A pharmacological activator of TRPV4, 4α-phorbol 12, 13-didecanoate (4αPDD), increased chondrogenesis. The findings suggest that Ca2+ signaling activated by mechanical stress and regulated by TRPV4 promotes chondrogenesis in ATDC5 cells. This suggests that artificial activation of TRPV4 may serve as an intervention for treating osteoarthritis.

  5. Inhibition of CD44 cleavage suppresses the chondrocyte de-differentiation

    Grant number:25462366  2013.4 - 2016.3

    Takahashi Nobunori

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    Authorship:Coinvestigator(s) 

    We mainly demonstrated that the excess mechanical stress loading can induce the CD44 fragmentation via the activation of TRPV4, a primary mechano-receptor, and the increased ADAM10 expression. CD44 fragmentation results in decreased ‘functional’ hyaluronan receptors and increased CD44 intracellular domain, leading to the diminished extracellular matrix in a chondrocyte. We also demonstrated that we successfully suppress the CD44 fragmentation using a TRPV4 antagonist or ADAM10 inhibitors under the mechanical stress loading condition. We will be able to start the in vivo study using animal osteoarthritis models as a next step.

  6. Evidence based communication model: mixed method

    Grant number:21590708  2009.4 - 2014.3

    KOJIMA Masayo

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    The aim of this study is to explorer the differences between patients with rheumatoid arthritis (RA) and their doctors in preferences and attitudes toward treatments from various perspectives by using qualitative and epidemiological research methods.
    We conducted two focus groups with 11 patients and with 10 rheumatologists, respectively. The content analysis revealed that RA patients made efforts to get information about treatments and to have good communications with their doctors. Rheumatologists were also trying various approaches to help their patients make clinical decisions. Self-reported questionnaires were distributed to 110 doctors and 1100 patients, and returned from 101 doctors and 798 patients. Patients whose doctors reported that they always explained treatment goals to their patients and/ or who reported that they had talked about treatment goals with their doctors were more likely to be satisfied with the current treatments comparing to others.

  7. 軟骨細胞の代謝に対する各種薬剤の影響の検討―スクリーニングシステムの構築―

    Grant number:20659230  2008 - 2009

    石黒 直樹

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    Authorship:Coinvestigator(s) 

    sox9遺伝子のプロモーターのNCBIのデータベースから得たシークエンス情報を元にレポーター遺伝子を作成した。恒常的にsox9遺伝子が発現し、SOX9蛋白が合成されている事を確認した細胞株(HCS2/8)にウイルスベクターを用いてレポーター遺伝子を導入し、発現細胞を作成した。Sox9レポーター遺伝子導入発現細胞株において、導入前と変化無くsox9遺伝子が発現されている事を確認した。この細胞を用いて約2000種の薬物についてsox9遺伝子の発現に与える影響を調べた。このスクリーニングデータを基に発現量増強に働く薬剤を数種類選別した。これら薬剤についてHCS2/8、ヒト軟骨細胞において同様にsox9発現増強効果が認められた候補物質を数種類選別した。さらにSOX9の標的遺伝子であるType II collagen, Proteoglycan遺伝子についてmRNA発現量の変化をPCRで確認した。同時にWestern blotにてタンパク量の変化を確認した。これらスクリーニングデータを基に最終的に標的遺伝子の発現量を増加させた化合物2種類を選定した。これら化合物は共にSOX9の発現量を増加させると共にその下流にあると考えられるプロテオグリカン、type II collagenのmRNA発現、蛋白合成も増加させた。OA軟骨組織器官培養系において確認する必要がある。今後これら化合物については自然発症OA動物モデルなどで効果を確認する必要がある。これら物質は変形性関節症を始めとする各種関節症疾患の治療薬開発の糸口を提供する可能性がある。更に、骨折治癒過程が内軟骨性骨化によることを考えれば、骨折治癒促進作用についても十分に期待できる薬剤であると考えている。

  8. Midkine RNA interferance関節内投与による関節炎治療

    Grant number:18659440  2006 - 2007

    萌芽研究

    石黒 直樹

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    特定関節に対する関節注射による関節炎治療は整形外科特有で有用な治療法であり、現状でも広く行われている治療である。Midkineは炎症性細胞遊走に関わり、Knock-out mouseを用いた抗体起因性の関節炎モデルでは関節炎が抑制された。又、RA患者では関節液、血清中の濃度が上昇していた。炎症性細胞遊走や血管新生に関わるMidkineの抑制は関節炎症の治療法として有望であると思われる。阻害効果が強いとされるRNA干渉(RNA interference, RNAi)を用いたMidkine抑制による関節炎治療の可能性を検討した。関節内投与による関節炎抑制の目的達成に向けて、比較的不安定と考えられるsiRNAの導入効率について検討した。細胞培養実験でGFPラットから筋細胞、骨髄間葉系細胞、線維細胞を採取して培養、RNAiによるGFP阻害の最適なsiRNAデザインを複数候補決定した。培養細胞では固定標本作成後の蛍光顕微鏡下で観察して、GFP蛍光の消失によりsiRNAが導入されたこと、特に線維芽細胞でのRNAi発生が高率であることが確認できた。これは滑膜組織に導入効率が高い事を示唆する結果であった。複数種のsiRNAカクテルによる抑制を検討し、至適条件の設定に成功した。細胞培養条件での導入効率向上に成功した。更に動物実験での関節投与でsiRNAiの導入効率上昇を目的とした関節注射担体(carrier)の開発に向けた検討を行った。前述のGFP遺伝子に対するsiRNAを作成して、各種の導入方法を試みた。エレクトロポレーション、リポフェクション等と比較してアテロコラーゲンを担体とした場合が優れた導入効率を示した。投入効率評価には蛍光顕微鏡観察によって蛍光を観察することにより行った。更にRNA抽出後ライトサイクラーにて定量的RT-PCRを行い、GFP阻害効果を定量化して、抑制効果の定量化を行った。

  9. The application of osteoblast-like cells and platelet rich plasma gels transplantation for accelerating the bone regeneration in the distraction osteogenesis.

    Grant number:14370461  2002 - 2004

    ISHIGURO Naoki

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    Distraction osteogenesis has been successfully used for limb lengthening in patients with limb length discrepancy, severe short stature due to skeletal dysplasias. Although this treatment method is biological and has many advantages for these pathological conditions, the periods of external fixation and bone maturation is long which results in higher rates of complications such as pin track infection, joint contractures, pin loosening, delayed consolidations and fractures. The distraction osteogenesis is considered as bone regeneration models in human. So we developed rat models, and to investigate the possibility of accelerating bone formation of the distracted callus with usage of combination of cells and suitable scaffold. Bone marrow contains a population of multipotent mesenchymal stem cells(MSCs) that can be directed towards the osteogenic lineage in vitro if cultured in the presence of dexamethasone, β-glycerophosphate and ascorbic acid. Using the rat limb lengthening model, we revealed that transplantation of marrow derived osteoblast-like cells with collagen gel into the distracted callus promoted new bone formation and shortened the consolidation period. Also the hrFGF-2 and hrBMP-2 could stimulate the matrix synthesis and proliferation of this osteoblast-like cells derived from MSCs. The osteogenic potential of rat MSCs were reduced with passaging. In the P3 cells, osteogenic potential was severely suppressed. After acquiring these insights, we planed the clinical application of osteoblast-like cell transplantation. We started the clinical research of limb lengthening with osteoblast-like cells and plate rich plasma gels for achondroplasia and hypochondoroplasia patients under the supervision of institutional reviewer boards in Nagoya university hospital. Although the results were preliminary, transplantation of osteoblast-like cells and PRP could shorten the treatment period by acceleration of bone regeneration during distraction osteogenesis. It was clearly demantrated that eatablishiment of the culture conditions permitting the rapid expansion of MSCs is required for improvement of clinical results.

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Social Contribution 1

  1. リウマチ治療ガイドライン作成

    2011.4 - 2014.3

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    リウマチ治療ガイドライン作成を行った