研究者詳細 - 丸山　彰一

論文 - 丸山　彰一

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Urinary Basigin/CD147 is a useful marker of acute T cell-mediated rejection in kidney transplant recipients Open Access

Futamura, K; Tsujita, M; Kosugi, T; Ryuge, A; Okada, M; Hiramitsu, T; Narumi, S; Takeda, A; Watarai, Y; Morozumi, K; Maruyama, S

RENAL FAILURE 47 巻 ( 1 ) 頁： 2479574 2025年12月

Urinary presepsin can efficiently detect T-cell-mediated rejection in patients who have undergone kidney transplantation

Kawazoe, T; Tanaka, A; Furuhashi, K; Hattori, K; Onogi, C; Owaki, A; Kato, A; Watanabe, Y; Koshi-Ito, E; Kato, N; Kosugi, T; Sano, Y; Ishida, S; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2025年4月

Ameliorative Effect of an Anti-microRNA-21 Oligonucleotide on Animal and Human Models of Cystic Kidney Disease. Open Access

Noda Y, Kato N, Sato F, Suzuki Y, Tsubota S, Kitai H, Komatsu S, Tanaka A, Sato Y, Maeda K, Furuhashi K, Ishimoto T, Kosugi T, Yamaguchi T, Nagao S, Kamiya Y, Kadomatsu K, Asanuma H, Maruyama S

Kidney360 2025年4月

Recurrent localized fever caused by cryoglobulinemic vasculitis following hemodialysis: A case report

Kojima, M; Shibata, M; Tomita, S; Ueda, R; Kasai, R; Yamamoto, E; Ban, AYK; Suzuki, S; Maruyama, S

CEN CASE REPORTS 14 巻 ( 2 ) 頁： 151 - 156 2025年4月

MPO-ANCA-positive rapidly progressive glomerulonephritis after COVID-19 vaccination during treatment of plaque psoriasis with bimekizumab

Sugiura, T; Doke, T; Tanaka, A; Sato, Y; Maeda, K; Furuhashi, K; Kato, N; Kosugi, T; Maruyama, S

CEN CASE REPORTS 14 巻 ( 2 ) 頁： 194 - 199 2025年4月

Establishing Cross-Specialty Expert Consensus on the Optimal Management of Hyperkalemia in Patients With Heart Failure and Chronic Kidney Disease Open Access

Kitai, T; Maruyama, S; Kuwahara, K; Tamura, K; Kinugawa, K; Kashihara, N

CIRCULATION JOURNAL 89 巻 ( 4 ) 頁： 470 - 478 2025年4月

Real-world safety profile of eculizumab in patients with paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, or generalized myasthenia gravis: an integrated analysis of post-marketing surveillance in Japan ( vol 118, pg 419, 2023)

Nishimura, JI; Kawaguchi, T; Ito, S; Murai, H; Shimono, A; Matsuda, T; Fukamizu, Y; Akiyama, H; Hayashi, H; Nakano, T; Maruyama, S

INTERNATIONAL JOURNAL OF HEMATOLOGY 121 巻 ( 4 ) 頁： 560 - 562 2025年4月

Temporal changes of the life and renal prognoses of patients with rapidly progressive glomerulonephritis in Japan, 1989-2019 Open Access

Nakajima, K; Kaneko, S; Usui, J; Tsuboi, N; Sugiyama, H; Maruyama, S; Isaka, Y; Narita, I; Yamagata, K

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2025年3月

In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney Open Access

Tsuboi, T; Hattori, K; Ishimoto, T; Imai, K; Doke, T; Hagita, J; Ariyoshi, J; Furuhashi, K; Kato, N; Ito, Y; Kamiya, Y; Asanuma, H; Maruyama, S

MOLECULAR THERAPY NUCLEIC ACIDS 36 巻 ( 1 ) 頁： 102387 2025年3月

A digest of the clinical practice guideline for pediatric idiopathic nephrotic syndrome 2020 updated: medical therapy

Hamada, R; Kaku, Y; Inaba, A; Kaito, H; Kimata, T; Kondo, S; Sako, M; Sato, M; Sugimoto, K; Tanaka, S; Nagaoka, Y; Nozu, K; Hashimoto, J; Miura, K; Yamamoto, M; Kawai, F; Maruyama, S; Ishikura, K

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2025年3月

Plasma Metabolite Profiles Between In-Center Daytime Extended-Hours and Conventional Hemodialysis Open Access

Takami, N; Okazaki, M; Ozeki, T; Imaizumi, T; Nishibori, N; Kurasawa, S; Hishida, M; Akiyama, S; Saito, R; Hirayama, A; Kasuga, H; Kaneda, F; Maruyama, S

KIDNEY360 6 巻 ( 3 ) 頁： 420 - 431 2025年3月

Clinically meaningful eGFR slope as a surrogate endpoint differs across CKD stages and slope evaluation periods: the CKD-JAC study Open Access

Imaizumi, T; Komaba, H; Hamano, T; Nangaku, M; Murotani, K; Hasegawa, T; Fujii, N; Nitta, K; Isaka, Y; Wada, T; Maruyama, S; Fukagawa, M

CLINICAL KIDNEY JOURNAL 18 巻 ( 2 ) 頁： sfae398 2025年2月

Unexpected Hypotension in a Female Patient with Fabry Disease: Switching from Agalsidase α to β after Long-term ERT Open Access

Sugiura, T; Muto, R; Amano, T; Kamiya, F; Sato, Y; Maeda, K; Saito, S; Katsuno, T; Kato, N; Higashi, M; Numaguchi, A; Matsuda, N; Sugiura, K; Maruyama, S

INTERNAL MEDICINE advpub 巻 ( 0 ) 2025年2月

Longitudinal impact of extended-hours hemodialysis with a liberalized diet on nutritional status and survival outcomes: findings from the LIBERTY cohort Open Access

Imaizumi, T; Okazaki, M; Hishida, M; Kurasawa, S; Nishibori, N; Nakamura, Y; Ishikawa, S; Suzuki, K; Takeda, Y; Otobe, Y; Kondo, T; Kaneda, F; Kaneda, H; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2025年1月

Association between Serum Zinc Levels and Trabecular Bone Scores among Patients Undergoing Chronic Hemodialysis

Hori, M; Takahashi, H; Kondo, C; Takeda, A; Morozumi, K; Maruyama, S

AMERICAN JOURNAL OF NEPHROLOGY 頁： 1 - 7 2025年1月

Development and validation of an algorithm for identifying patients undergoing dialysis from patients with advanced chronic kidney disease Open Access

Imaizumi, T; Yokota, T; Funakoshi, K; Yasuda, K; Hattori, A; Morohashi, A; Kusakabe, T; Shojima, M; Nagamine, S; Nakano, T; Huang, Y; Morinaga, H; Ohta, M; Nagashima, S; Inoue, R; Nakamura, N; Ota, H; Maruyama, T; Gobara, H; Endoh, A; Ando, M; Shiratori, Y; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2025年1月

Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance

Furuhashi, K; Kakiuchi, M; Ueda, R; Oda, H; Ummarino, S; Ebralidze, AK; Bassal, MA; Meng, C; Sato, T; Lyu, J; Han, MG; Maruyama, S; Watanabe, Y; Sawa, Y; Kato, D; Wake, H; Reizis, B; Frangos, JA; Owens, DM; Tenen, DG; Ghiran, IC; Robson, SC; Fujisaki, J

NATURE 638 巻 ( 8049 ) 頁： 206 - 215 2025年1月

Randomised, double-blind study to evaluate the efficacy of rituximab in the treatment of idiopathic membranous nephropathy: A clinical trial protocol. Open Access

Shimizu S, Tanaka A, Matsuyama N, Kinoshita F, Furuhashi K, Maruyama S, PRIME Study Group

PloS one 20 巻 ( 3 ) 頁： e0320070 2025年

Factors associated with awareness of chronic kidney disease, and impact of awareness on renal prognosis Open Access

Hattori, A; Imaizumi, T; Toda, T; Sakurai, D; Takai, N; Miki, T; Maekawa, M; Kato, S; Hagiwara, Y; Yoshida, Y; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2024年12月

SUrvey of renal Biopsy registry database and Anticancer dRUg therapy in Japan (SUBARU-J study) Open Access

Kuwabara, T; Miyasato, Y; Kanki, T; Mizumoto, T; Matsubara, T; Sawa, N; Sugiyama, H; Maruyama, S; Sato, H; Tsukamoto, T; Murata, T; Miyazaki, M; Imasawa, T; Mukoyama, M; Murakami, N; Jhaveri, KD; Yanagita, M; JSN Onconephrology Working Grp

CLINICAL KIDNEY JOURNAL 17 巻 ( 12 ) 頁： sfae327 2024年12月

Urinary presepsin is a novel biomarker capable of directly assessing monocyte/macrophage infiltration in kidney diseases Open Access

Niwa, S; Tanaka, A; Furuhashi, K; Hattori, K; Onogi, C; Sunohara, K; Owaki, A; Kato, A; Kawazoe, T; Watanabe, Y; Koshi-Ito, E; Kato, N; Kosugi, T; Maruyama, S

SCIENTIFIC REPORTS 14 巻 ( 1 ) 頁： 30088 2024年12月

Association between alpha blocker use and the risk of fractures in patients with chronic kidney disease: a cohort study Open Access

Sunohara, K; Onogi, C; Tanaka, A; Furuhashi, K; Matsumoto, J; Hattori, K; Owaki, A; Kato, A; Kawazoe, T; Watanabe, Y; Koshi-Ito, E; Maruyama, S

BMC NEPHROLOGY 25 巻 ( 1 ) 頁： 442 2024年12月

Effect of tonsillectomy combined with steroid pulse therapy upon IgA nephropathy depending on proteinuria status at diagnosis: a nationwide multicenter cohort study in Japan Open Access

Komatsu, H; Fujimoto, S; Sato, Y; Yasuda, T; Yasuda, Y; Matsuzaki, K; Hirano, K; Kawamura, T; Yokoo, T; Suzuki, Y; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 28 巻 ( 12 ) 頁： 1272 - 1281 2024年12月

A case of non-traumatic rectus sheath hematoma in a post-kidney transplant patient undergoing catheter embolization during anticoagulation treatment for atrial fibrillation Open Access

Fujieda, K; Saito, S; Tanaka, A; Furuhashi, K; Ozeki, T; Yasuda, Y; Sano, Y; Ishida, S; Maruyama, S

CEN CASE REPORTS 13 巻 ( 6 ) 頁： 528 - 533 2024年12月

Associations of anaemia and iron deficiency with health-related quality of life in patients with chronic kidney disease stage G3b-5 in Japan: sub analysis of the Reach-J CKD cohort study Open Access

Okubo, R; Ohigashi, T; Kondo, M; Tsunoda, R; Kai, HRYS; Saito, C; Hoshino, J; Okada, H; Narita, I; Maruyama, S; Wada, T; Yamagata, K

BMC NEPHROLOGY 25 巻 ( 1 ) 頁： 414 2024年11月

Association between proteinuria and mineral metabolism disorders in chronic kidney disease: the Japan chronic kidney disease database extension (J-CKD-DB-Ex) Open Access

Shimamoto, S; Nakahara, T; Yamada, S; Nagasu, H; Kishi, S; Nakashima, N; Tsuruya, K; Okada, H; Tamura, K; Narita, I; Maruyama, S; Yano, Y; Yokoo, T; Wada, T; Wada, J; Kanda, E; Kataoka, H; Nangaku, M; Kashihara, N; Nakano, T

SCIENTIFIC REPORTS 14 巻 ( 1 ) 頁： 27481 2024年11月

Physical activity and renal outcome in diabetic and non-diabetic patients with chronic kidney disease stage G3b to G5 Open Access

Hoshino, J; Ohigashi, T; Tsunoda, R; Ito, Y; Kai, H; Saito, C; Okada, H; Narita, I; Wada, T; Maruyama, S; Pisoni, R; Pecoits, R; Yamagata, K

SCIENTIFIC REPORTS 14 巻 ( 1 ) 頁： 26378 2024年11月

Eculizumab for adult patients with atypical haemolytic-uraemic syndrome: full dataset analysis of Japanese post-marketing surveillance Open Access

Maruyama, S; Ikeda, Y; Kaname, S; Kato, N; Matsumoto, M; Ishikawa, Y; Shimono, A; Miyakawa, Y; Nangaku, M; Shibagaki, Y; Okada, H

JOURNAL OF NEPHROLOGY 37 巻 ( 8 ) 頁： 2181 - 2190 2024年11月

Analysis of the impact of obesity on the prognosis of IgA nephropathy according to renal function and sex

Ariyasu, Y; Torikoshi, K; Tsukamoto, T; Yasuda, T; Yasuda, Y; Matsuzaki, K; Hirano, K; Kawamura, T; Yokoo, T; Maruyama, S; Suzuki, Y; Muso, E

CLINICAL AND EXPERIMENTAL NEPHROLOGY 28 巻 ( 11 ) 頁： 1155 - 1167 2024年11月

Safety and Tolerability of Adipose-Derived Mesenchymal Stem Cell (ADR-001) Therapy for IgA Nephropathy Open Access

Tanaka, A; Furuhashi, K; Fujieda, K; Horinouchi, A; Maeda, K; Saito, S; Mimura, T; Saka, Y; Naruse, T; Ishimoto, T; Kato, N; Kosugi, T; Kinoshita, F; Kuwatsuka, Y; Nakai, Y; Maruyama, S

KIDNEY360 5 巻 ( 11 ) 頁： 1692 - 1705 2024年11月

Correlation between a 2-week change in platelet count and clinical outcomes after the initiation of ravulizumab treatment in adult patients with atypical hemolytic uremic syndrome: post-hoc analysis of the phase III trial Open Access

Matsumoto, M; Shimono, A; Yokosawa, J; Hirose, K; Wang, ED; Maruyama, S

THROMBOSIS JOURNAL 22 巻 ( 1 ) 頁： 93 2024年10月

C1q Binding Ability for Prior Risk Assessment of Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation Open Access

Miwa, Y; Iwasaki, K; Murotani, K; Okada, M; Nagasaka, T; Watarai, Y; Takeda, A; Shizuku, M; Ashimine, S; Ishiyama, K; Maruyama, S; Kobayashi, T

TRANSPLANT INTERNATIONAL 37 巻頁： 13407 2024年10月

A case of late-onset organizing pneumonia following COVID-19 infection in a post-kidney transplant patient 査読有り Open Access

Fujieda, K; Saito, S; Tanaka, A; Furuhashi, K; Yasuda, Y; Sano, Y; Kato, M; Maruyama, S

CEN CASE REPORTS 13 巻 ( 5 ) 頁： 346 - 350 2024年10月

Association of Proteinuria Remission and Its Timing with Kidney Outcomes in Patients with Focal Segmental Glomerulosclerosis

Kawaguchi, T; Imasawa, T; Kadomura, M; Kitamura, H; Ozeki, T; Katafuchi, R; Oka, K; Furuichi, K; Isaka, Y; Sato, H; Sugiyama, H; Maruyama, S

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 35 巻 ( 10 ) 2024年10月

A Case of Tiopronin-induced Membranous Nephropathy Presenting with IgG4-predominant Staining Pattern Open Access

Yamashita, J; Hirakawa, Y; Sato, Y; Abe, H; Akiyama, S; Maruyama, S; Kume, H; Nangaku, M

INTERNAL MEDICINE 64 巻 ( 7 ) 頁： 1079 - 1083 2024年9月

Cardiovascular, renal and mortality risk by the KDIGO heatmap in Japan Open Access

Maruyama, S; Tanaka, T; Akiyama, H; Hoshino, M; Inokuchi, S; Kaneko, S; Shimamoto, K; Ozaki, A

CLINICAL KIDNEY JOURNAL 17 巻 ( 8 ) 頁： sfae228 2024年8月

Annual trends in atypical haemolytic uremic syndrome management in Japan and factors influencing early diagnosis and treatment: a retrospective study Open Access

Tatematsu, Y; Imaizumi, T; Michihata, N; Kato, N; Kumazawa, R; Matsui, H; Fushimi, K; Yasunaga, H; Maruyama, S

SCIENTIFIC REPORTS 14 巻 ( 1 ) 頁： 18265 2024年8月

Changes in antibody titer after four and five doses of the SARS-CoV-2 vaccine in Japanese post-kidney transplant patients 査読有り

Fujieda, K; Tanaka, A; Kikuchi, R; Takai, N; Saito, S; Yasuda, Y; Sano, Y; Kato, M; Furuhashi, K; Maruyama, S

THERAPEUTIC APHERESIS AND DIALYSIS 28 巻 ( 4 ) 頁： 489 - 498 2024年8月

Importance of education on steroid cover: a case of hyponatremia after dental extraction with local anesthesia in a patient with idiopathic hypopituitarism 査読有り Open Access

Nakamura, Y; Saito, S; Okada, N; Yamakawa, T; Maruyama, S

CEN CASE REPORTS 13 巻 ( 4 ) 頁： 308 - 309 2024年8月

Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease 査読有り

Kishi, S; Nakashima, T; Goto, T; Nagasu, H; Brooks, CR; Okada, H; Tamura, K; Nakano, T; Narita, I; Maruyama, S; Yano, Y; Yokoo, T; Wada, T; Wada, J; Nangaku, M; Kashihara, N

CLINICAL AND EXPERIMENTAL NEPHROLOGY 28 巻 ( 8 ) 頁： 784 - 792 2024年8月

Prognosis of microscopic polyangiitis is well predictable in the first 2 weeks of treatment Open Access

Owaki, A; Tanaka, A; Furuhashi, K; Watanabe, Y; Koshi-Ito, E; Imaizumi, T; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 28 巻 ( 7 ) 頁： 701 - 706 2024年7月

Factors affecting the sodium-glucose cotransporter 2 inhibitors-related initial decline in glomerular filtration rate and its possible effect on kidney outcome in chronic kidney disease with type 2 diabetes: The Japan Chronic Kidney Disease Database

Kanaoka, T; Wakui, H; Yano, Y; Nagasu, H; Kanegae, H; Nangaku, M; Hirakawa, Y; Nakagawa, N; Wada, J; Tsuruya, K; Nakano, T; Maruyama, S; Wada, T; Konishi, M; Nagahiro, T; Yamagata, K; Narita, I; Yanagita, M; Terada, Y; Araki, S; Emoto, M; Okada, H; Isaka, Y; Suzuki, Y; Yokoo, T; Kataoka, H; Kanda, E; Kashihara, N; Tamura, K

DIABETES OBESITY & METABOLISM 26 巻 ( 7 ) 頁： 2905 - 2914 2024年7月

Detecting and exploring kidney-derived extracellular vesicles in plasma 査読有り Open Access

Komatsu, S; Kato, N; Kitai, H; Funahashi, Y; Noda, Y; Tsubota, S; Tanaka, A; Sato, Y; Maeda, K; Saito, S; Furuhashi, K; Ishimoto, T; Kosugi, T; Maruyama, S; Kadomatsu, K

CLINICAL AND EXPERIMENTAL NEPHROLOGY 28 巻 ( 7 ) 頁： 617 - 628 2024年7月

Ferroelectric polycrystalline Bi2SiO5 thin films on Pt-covered Si substrates prepared by pulsed laser deposition combined with post-annealing

Takahashi, H; Maruyama, S; Naganuma, H; Taniguchi, H; Takahashi, R; Yasui, S; Kaminaga, K; Matsumoto, Y

JOURNAL OF ALLOYS AND COMPOUNDS 988 巻 2024年6月

Association of calciprotein particles with serum phosphorus among patients undergoing conventional and extended-hours haemodialysis Open Access

Nishibori, N; Okazaki, M; Miura, Y; Hishida, M; Kurasawa, S; Imaizumi, T; Kato, N; Kosugi, T; Kuro-o, M; Kasuga, H; Kaneda, F; Maruyama, S

CLINICAL KIDNEY JOURNAL 17 巻 ( 6 ) 頁： sfae121 2024年6月

Effects of empagliflozin in patients with chronic kidney disease from Japan: exploratory analyses from EMPA-KIDNEY Open Access

Nangaku, M; Herrington, WG; Goto, S; Maruyama, S; Kashihara, N; Ueki, K; Wada, J; Watada, H; Nakashima, E; Lee, RYF; Massey, D; Mayne, KJ; Tomita, A; Haynes, R; Hauske, SJ; Kadowaki, T

CLINICAL AND EXPERIMENTAL NEPHROLOGY 28 巻 ( 6 ) 頁： 588 - 595 2024年6月

Association between Serum 25-Hydroxyvitamin D Levels and Sarcopenia in Patients Undergoing Chronic Haemodialysis

Hori, M; Takahashi, H; Kondo, C; Hayashi, F; Tokoroyama, S; Mori, Y; Tsujita, M; Shirasawa, Y; Takeda, A; Morozumi, K; Maruyama, S

AMERICAN JOURNAL OF NEPHROLOGY 55 巻 ( 3 ) 頁： 399 - 405 2024年6月

Clinical impact of proteinuria and hematuria remission criteria in IgA nephropathy patients defined by the Japanese Society of Nephrology Open Access

Yasuda, Y; Kaihan, AB; Kaihan, AN; Tanaka, A; Imaizumi, T; Maeda, K; Kato, N; Kosugi, T; Maruyama, S

NEPHROLOGY DIALYSIS TRANSPLANTATION 39 巻 2024年5月

Evaluating the associations between compliance with CKD guideline component metrics and renal outcomes Open Access

Nyma, Z; Kitaoka, K; Yano, Y; Kanegae, H; Bayaraa, N; Kishi, S; Nagasu, H; Nakano, T; Wada, J; Maruyama, S; Nakagawa, N; Tamura, K; Yokoo, T; Yanagita, M; Narita, I; Yamagata, K; Wada, T; Tsuruya, K; Nakashima, N; Isaka, Y; Nangaku, M; Kashihara, N; Okada, H

SCIENTIFIC REPORTS 14 巻 ( 1 ) 頁： 11481 2024年5月

Relationship between peak aortic jet velocity and progression of aortic stenosis in patients undergoing hemodialysis 査読有り

Kurasawa, S; Imaizumi, T; Kondo, T; Hishida, M; Okazaki, M; Nishibori, N; Takeda, Y; Kasuga, H; Maruyama, S

INTERNATIONAL JOURNAL OF CARDIOLOGY 402 巻頁： 131822 2024年5月

SUrvey of renal Biopsy database and Anti-cancer dRUg therapy in Japan (SUBARU-J study)

Kuwabara, T; Miyasato, Y; Kanki, T; Mizumoto, T; Matsubara, T; Sawa, N; Sugiyama, H; Maruyama, S; Mukoyama, M; Murakami, N; Jhaveri, K; Yanagita, M

NEPHROLOGY DIALYSIS TRANSPLANTATION 39 巻頁： I984 - I985 2024年5月

Safety and Tolerability of adipose-derived mesenchymal stem cell "ADR-001" in the treatment of immunoglobulin A nephropathy

Maruyama, S; Tanaka, A; Furuhashi, K; Fujieda, K; Maeda, K; Mimura, T; Saka, Y; Naruse, T; Ishimoto, T; Kosugi, T

NEPHROLOGY DIALYSIS TRANSPLANTATION 39 巻頁： I740 - I740 2024年5月

Interstitial fibrosis and tubular atrophy of immune checkpoint inhibitor-related interstitial nephritis associate mortality and kidney prognosis

Matsubara, T; Yamamoto, S; Kuwabara, T; Miyazawa, S; Miyasato, Y; Sawa, N; Sugiyama, H; Maruyama, S; Mukoyama, M; Yanagita, M

NEPHROLOGY DIALYSIS TRANSPLANTATION 39 巻頁： I680 - I680 2024年5月

Association between anemia/iron deficiency and health-related quality of life in patients with advanced CKD: the Reach-J CKD cohort study

Okubo, R; Ohigashi, T; Kondo, M; Tsunoda, R; Kai, H; Saito, C; Okada, H; Narita, I; Hoshino, J; Maruyama, S; Wada, T; Yamagata, K

NEPHROLOGY DIALYSIS TRANSPLANTATION 39 巻頁： I2374 - I2374 2024年5月

Calciprotein particles and phosphorus in conventional and extended-hours hemodialysis

Nishibori, N; Okazaki, M; Imaizumi, T; Miura, Y; Kuro-O, M; Kasuga, H; Kaneda, F; Maruyama, S

NEPHROLOGY DIALYSIS TRANSPLANTATION 39 巻頁： I2538 - I2538 2024年5月

Cardiovascular, renal and mortality risk by the KDIGO risk classification: the first observational study in Japan

Maruyama, S; Akiyama, H; Ozaki, A; Tanaka, T

NEPHROLOGY DIALYSIS TRANSPLANTATION 39 巻頁： I1017 - I1019 2024年5月

Characteristics of patients with aHUS who discontinued dialysis after eculizumab treatment: sub-analysis of post-marketing surveillance in Japan

Ito, S; Matsumoto, M; Shimono, A; Teranishi, H; Maruyama, S

NEPHROLOGY DIALYSIS TRANSPLANTATION 39 巻頁： I1899 - I1899 2024年5月

Clinical impact of proteinuria and hematuria remission criteria in IgA nephropathy patients defined by the Japanese Society of Nephrology

Yasuda, Y; Kaihan, AB; Kaihan, AN; Tanaka, A; Imaizumi, T; Maeda, K; Kato, N; Kosugi, T; Maruyama, S

NEPHROLOGY DIALYSIS TRANSPLANTATION 39 巻頁： I736 - I737 2024年5月

Development and validation of risk prediction models according to different clinical settings of IgA nephropathy: nationwide multicenter cohort study

Hirano, K; Ikenoue, T; Yasuda, T; Yasuda, Y; Maruyama, S; Yokoo, T; Suzuki, H; Suzuki, Y; Fukuma, S

NEPHROLOGY DIALYSIS TRANSPLANTATION 39 巻頁： I679 - I679 2024年5月

Influence of SGLT2I on tubulointerstitium in DKD patients with moderate renal dysfunction

Murakami, K; Kato, S; Sugaya, T; Kuwatsuka, Y; Ando, M; Maruyama, S

NEPHROLOGY DIALYSIS TRANSPLANTATION 39 巻頁： I110 - I111 2024年5月

Rationale and design of the Japanese Biomarkers in Nephrotic Syndrome (J-MARINE) study 査読有り

Kurasawa, S; Kato, S; Ozeki, T; Akiyama, S; Ishimoto, T; Mizuno, M; Tsuboi, N; Kato, N; Kosugi, T; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 28 巻 ( 5 ) 頁： 431 - 439 2024年5月

Macrophage-1 antigen exacerbates histone-induced acute lung injury and promotes neutrophil extracellular trap formation 査読有り Open Access

Mizuno, T; Nagano, F; Takahashi, K; Yamada, S; Fruhashi, K; Maruyama, S; Tsuboi, N

FEBS OPEN BIO 14 巻 ( 4 ) 頁： 574 - 583 2024年4月

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits and atypical pathological findings treated with corticosteroid and rituximab 査読有り Open Access

Mori, M; Tanaka, A; Maeda, K; Saito, S; Furuhashi, K; Maruyama, S

CEN CASE REPORTS 13 巻 ( 2 ) 頁： 128 - 134 2024年4月

Case report: A family of atypical hemolytic uremic syndrome involving a CFH::CFHR1 fusion gene and CFHR3-1-4-2 gene duplication 査読有り Open Access

Tasaki, Y; Tsujimoto, H; Yokoyama, T; Sugimoto, N; Kitajima, S; Fujii, H; Hidaka, Y; Kato, N; Maruyama, S; Inoue, N; Wada, T

FRONTIERS IN IMMUNOLOGY 15 巻頁： 1360855 2024年3月

Association between stopping renin-angiotensin system inhibitors immediately before hemodialysis initiation and subsequent cardiovascular events 査読有り Open Access

Nakamura, Y; Inaguma, D; Imaizumi, T; Kurasawa, S; Hishida, M; Okazaki, M; Fujishima, Y; Nishibori, N; Suzuki, K; Takeda, Y; Maruyama, S

HYPERTENSION RESEARCH 47 巻 ( 5 ) 頁： 1372 - 1379 2024年3月

Population characteristics and diagnosis rate of chronic kidney disease by eGFR and proteinuria in Japanese clinical practice: an observational database study 査読有り Open Access

Tanaka, T; Maruyama, S; Chishima, N; Akiyama, H; Shimamoto, K; Inokuchi, S; Yokota, K; Ozaki, A

SCIENTIFIC REPORTS 14 巻 ( 1 ) 頁： 5172 2024年3月

特集出血傾向あるいは血栓傾向をきたす血小板減少症と血小板機能異常症【血栓傾向をきたす血小板減少症】非典型溶血性尿毒症症候群(aHUS)

加藤規利, 立枩良崇, 丸山彰一

医学のあゆみ 288 巻 ( 8 ) 頁： 656 - 660 2024年2月

Impact of an angulated aorto-septal relationship on cardio-cerebrovascular outcomes in patients undergoing hemodialysis 査読有り Open Access

Nakayama, T; Yamamoto, J; Ozeki, T; Tokoroyama, S; Mori, Y; Hori, M; Tsujita, M; Shirasawa, Y; Takeda, A; Kondo, C; Murata, M; Suzuki, S; Kinoshita, Y; Fukuda, M; Ueki, T; Ikehara, N; Sugiura, M; Goto, T; Hashimoto, H; Yajima, K; Maruyama, S; Koyama, H; Morozumi, K; Seo, Y

PLOS ONE 19 巻 ( 2 ) 頁： e0298637 2024年2月

Mortality and hyperkalaemia-associated hospitalisation in patients with chronic kidney disease: comparison of sodium zirconium cyclosilicate and sodium/calcium polystyrene sulfonate 査読有り Open Access

Onogi, C; Watanabe, Y; Tanaka, A; Furuhashi, K; Maruyama, S

CLINICAL KIDNEY JOURNAL 17 巻 ( 2 ) 頁： sfae021 2024年2月

Clinical characteristics of anti-GBM disease with thrombotic microangiopathy: a case report and literature review 査読有り Open Access

Nakamura, Y; Kato, N; Tatematsu, Y; Arai, Y; Mori, N; Shibata, K; Yamazaki, M; Yasui, H; Fujiwara, S; Yamakawa, T; Maruyama, S

CEN CASE REPORTS 13 巻 ( 1 ) 頁： 37 - 44 2024年2月

Establishment of an adverse effect prevention protocol on plasma exchange using fresh frozen plasma prior to ABO-incompatible living donor kidney transplantation at our hospital 査読有り

Tanaka, A; Watanabe, Y; Furuhashi, K; Saito, S; Yasuda, Y; Kosugi, T; Sano, Y; Kato, M; Maruyama, S

THERAPEUTIC APHERESIS AND DIALYSIS 28 巻 ( 1 ) 頁： 152 - 157 2024年2月

Clinicopathological prognostic stratification for proteinuria and kidney survival in IgA nephropathy: a Japanese prospective cohort study 査読有り Open Access

Koike, K; Kawamura, T; Hirano, K; Nishikawa, M; Shimizu, A; Joh, K; Katafuchi, R; Hashiguchi, A; Yano, Y; Matsuzaki, K; Matsushima, M; Tsuboi, N; Maruyama, S; Narita, I; Yokoo, T; Suzuki, Y

CLINICAL KIDNEY JOURNAL 17 巻 ( 1 ) 頁： sfad294 2024年1月

Overlapping Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy with Mutation in CFI in a Japanese Patient: A Case Report Open Access

Osawa, K; Yamamoto, S; Yamano, Y; Kita, A; Okamoto, K; Kato, N; Tatematsu, Y; Kojima, F; Ohya, M; Hara, S; Murata, SI; Inoue, N; Maruyama, S; Araki, SI

INTERNAL MEDICINE 63 巻 ( 12 ) 頁： 1777 - 1782 2024年

当院における移植後悪性腫瘍の検討 Open Access

佐野優太, 石田昇平, 佐野友康, 井上聡, 木村友和, 松川宜久, 尾関貴哉, 田中彰仁, 丸山彰一, 赤松秀輔

移植 59 巻 ( Supplement ) 頁： s326_2 - s326_2 2024年

記述言語：日本語出版者・発行元：一般社団法人日本移植学会

本邦の2010年～2020年における腎移植レシピエントの死亡原因として悪性腫瘍は第1位(16.6%)であり、免疫抑制下におかれる腎移植患者は悪性腫瘍発生の高リスクとされ、悪性腫瘍の発生状況や対策は重要な課題である。2002年より2022年12月までに当院で施行した腎移植179例を対象としレトロスペクティブに検討した。悪性腫瘍は15例（8.4%）に１７種の癌が発生した。内訳は腎癌5例、大腸癌3例、膵癌2例、子宮体癌１例、前立腺癌1例、膀胱癌1例、胃癌1例、肝細胞癌1例、慢性骨髄性白血病1例、甲状腺癌1例であった。癌発症群は発症なし群と比較して、レシピエント年齢が高く、献腎移植、急性拒絶反応が多く、観察期間が長かった。また癌発症群では生存率が低かったが、生着率（death-censored）には差がなかった。癌発症例のうち癌死は4例（26.7%）であった。全例death with functioning graftであった。腎移植後は悪性腫瘍の発生率が上がり、また死亡率も高く注意が必要である。定期的な健診や予防が推奨される。当院における腎移植後悪性腫瘍の発生状況につき若干の文献的考察を加え報告する。

DOI： 10.11386/jst.59.supplement_s326_2

Open Access

CiNii Research

Complement terminal pathway inhibition reduces peritoneal injuries in a rat peritonitis model 査読有り Open Access

Kamegai, N; Kim, H; Suzuki, Y; Fukui, S; Kojima, H; Maruyama, S; Morgan, BP; Zelek, WM; Mizuno, M

CLINICAL AND EXPERIMENTAL IMMUNOLOGY 214 巻 ( 2 ) 頁： 209 - 218 2023年12月

Association between serum iron markers, iron supplementation and cardiovascular morbidity in pre-dialysis chronic kidney disease 査読有り Open Access

Hasegawa, T; Imaizumi, T; Hamano, T; Murotani, K; Fujii, N; Komaba, H; Ando, M; Maruyama, S; Nangaku, M; Nitta, K; Hirakata, H; Isaka, Y; Wada, T; Fukagawa, M

NEPHROLOGY DIALYSIS TRANSPLANTATION 38 巻 ( 12 ) 頁： 2713 - 2722 2023年12月

Current status of low-density lipoprotein apheresis treatment for patients with peripheral artery disease and chronic kidney disease in Japanese clinical database 査読有り

Watanabe, Y; Tanaka, A; Furuhashi, K; Maruyama, S

THERAPEUTIC APHERESIS AND DIALYSIS 27 巻 ( 6 ) 頁： 1000 - 1009 2023年12月

Coexistence of low muscle mass and osteoporosis as a predictor of fragility fractures in long-term kidney transplant recipients 査読有り

Hori, M; Takahashi, H; Kondo, C; Matsuoka, Y; Tsujita, M; Nishihira, M; Uchida, K; Takeda, A; Morozumi, K; Maruyama, S

AMERICAN JOURNAL OF NEPHROLOGY 54 巻 ( 11-12 ) 頁： 489 - 497 2023年12月

Basigin is released in extracellular vesicles derived from the renal tubular epithelium in response to albuminuria 査読有り Open Access

Watanabe, T; Maeda, K; Kato, N; Seko, H; Sugimura, M; Sato, Y; Ryuge, A; Kato, S; Kadomatsu, K; Maruyama, S; Kosugi, T

NEPHROLOGY 28 巻 ( 11 ) 頁： 629 - 638 2023年11月

Mesenchymal stem/stromal cells generated from induced pluripotent stem cells are highly resistant to senescence 査読有り Open Access

Aoi, T; Tanaka, A; Furuhashi, K; Ikeya, M; Shimizu, A; Arioka, Y; Kushima, I; Ozaki, N; Maruyama, S

NAGOYA JOURNAL OF MEDICAL SCIENCE 85 巻 ( 4 ) 頁： 682 - 690 2023年11月

Relationship between the lower limit of systolic blood pressure target and kidney function decline in advanced chronic kidney disease: an instrumental variable analysis from the REACH-J CKD cohort study 査読有り

Kurasawa, S; Yasuda, Y; Kato, S; Maruyama, S; Okada, H; Kashihara, N; Narita, I; Wada, T; Yamagata, K

HYPERTENSION RESEARCH 46 巻 ( 11 ) 頁： 2478 - 2487 2023年11月

Reduced Glycolytic ATP Production Is Responsible for Irreversible Podocyte Injury in Nephrotic Syndrome

Sugimura, M; Maeda, K; Sato, Y; Kato, N; Kosugi, T; Maruyama, S

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 34 巻 ( 11 ) 頁： 298 - 298 2023年11月

Associations of corticosteroid therapy and tonsillectomy with kidney survival in a multicenter prospective study for IgA nephropathy 査読有り Open Access

Kawamura, T; Hirano, K; Koike, K; Nishikawa, M; Shimizu, A; Joh, K; Katafuchi, R; Hashiguchi, A; Matsuzaki, K; Maruyama, S; Tsuboi, N; Narita, I; Yano, Y; Yokoo, T; Suzuki, Y

SCIENTIFIC REPORTS 13 巻 ( 1 ) 頁： 18455 2023年10月

Novel function of transglutaminase 2 in extracellular histone-induced acute lung injury 査読有り

Mizuno, T; Nagano, F; Ito, Y; Tatsukawa, H; Shinoda, Y; Takeuchi, T; Takahashi, K; Tsuboi, N; Nagamatsu, T; Yamada, S; Maruyama, S; Hitomi, K

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 678 巻頁： 179 - 185 2023年10月

Nishimura, JI; Kawaguchi, T; Ito, S; Murai, H; Shimono, A; Matsuda, T; Fukamizu, Y; Akiyama, H; Hayashi, H; Nakano, T; Maruyama, S

INTERNATIONAL JOURNAL OF HEMATOLOGY 118 巻 ( 4 ) 頁： 419 - 431 2023年10月

The association of low serum magnesium levels with frailty among hemodialysis patients 査読有り Open Access

Hori, M; Yasuda, K; Takahashi, H; Morozumi, K; Maruyama, S

SCIENTIFIC REPORTS 13 巻 ( 1 ) 頁： 14982 2023年9月

Higher hemoglobin levels using darbepoetin alfa and kidney outcomes in advanced chronic kidney disease without diabetes: a prespecified secondary analysis of the PREDICT trial 査読有り Open Access

Maruyama, S; Kurasawa, S; Hayashi, T; Nangaku, M; Narita, I; Hirakata, H; Tanabe, K; Morita, S; Tsubakihara, Y; Imai, E; Akizawa, T; PREDICT Investigators

CLINICAL AND EXPERIMENTAL NEPHROLOGY 27 巻 ( 9 ) 頁： 757 - 766 2023年9月

Introduction

Kanetsuna, Y; Maruyama, S

NEPHRON 147 Suppl 1 巻頁： 5 2023年8月

Association of kidney function with cancer incidence and its influence on cancer risk of smoking: The Japan Multi-Institutional Collaborative Cohort Study 査読有り

Kurasawa, S; Imaizumi, T; Maruyama, S; Tanaka, K; Kubo, Y; Nagayoshi, M; Ikezaki, H; Suzuki, S; Koyama, T; Koriyama, C; Kadota, A; Katsuura-Kamano, S; Kuriki, K; Wakai, K; Matsuo, K

INTERNATIONAL JOURNAL OF CANCER 153 巻 ( 4 ) 頁： 732 - 741 2023年8月

Rationale and study design of a randomized controlled trial to investigate the renoprotective effect of canagliflozin assessed by test of renal hemodynamics in diabetic kidney disease (the FAGOTTO study) 査読有り Open Access

Kato, S; Kuwatsuka, Y; Ando, M; Tatematsu, Y; Nishibori, N; Maruyama, S

BMC NEPHROLOGY 24 巻 ( 1 ) 頁： 228 2023年8月

IgA-dominant glomerulonephritis with DNAJB9-negative fibrillar polytypic immunoglobulin deposits in the subepithelium 査読有り Open Access

Muto, R; Maeda, K; Fukui, S; Saito, S; Kato, N; Kosugi, T; Shimizu, A; Maruyama, S

CEN CASE REPORTS 12 巻 ( 3 ) 頁： 323 - 328 2023年8月

Clinical Course of Adult FSGS and Minimal Change Disease in North American and Japanese Cohorts 査読有り Open Access

Ozeki, T; Gillespie, BW; Larkina, M; Maruyama, S; Alakwaa, F; Kretzler, M; Mariani, LH

KIDNEY360 4 巻 ( 7 ) 頁： 924 - 934 2023年7月

Number of calcified aortic valve leaflets: natural history and prognostic value in patients undergoing haemodialysis 査読有り Open Access

Kurasawa, S; Okazaki, M; Imaizumi, T; Kondo, T; Hishida, M; Nishibori, N; Takeda, Y; Kasuga, H; Maruyama, S

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING 24 巻 ( 7 ) 頁： 909 - 920 2023年6月

Profiling of kidney involvement in systemic lupus erythematosus by deep learning using the National Database of Designated Incurable Diseases of Japan 査読有り Open Access

Kimura, T; Ikeuchi, H; Yoshino, M; Sakate, R; Maruyama, S; Narita, I; Hiromura, K

CLINICAL AND EXPERIMENTAL NEPHROLOGY 27 巻 ( 6 ) 頁： 519 - 527 2023年6月

Relapse of atypical hemolytic uremic syndrome triggered by COVID-19: a lesson for the clinical nephrologist 査読有り Open Access

Uwatoko, R; Shindo, M; Hashimoto, N; Iio, R; Ueda, Y; Tatematsu, Y; Kato, N; Maruyama, S; Hayashi, T

JOURNAL OF NEPHROLOGY 36 巻 ( 5 ) 頁： 1439 - 1442 2023年6月

Peritoneal Expression of Membrane Complement Regulators Is Decreased in Peritoneal Dialysis Patients with Infected Peritonitis 査読有り Open Access

Fukui, S; Mizuno, M; Tawada, M; Suzuki, Y; Kojima, H; Matsukawa, Y; Imai, M; Kim, H; Kinashi, H; Mizutani, M; Minoshima, K; Maruyama, S; Ito, Y

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24 巻 ( 11 ) 頁： 9146 2023年5月

TOPICS 腎臓内科学脂肪由来間葉系幹細胞による重症腎炎改善メカニズムの解明

古橋和拡, 田中章仁, 丸山彰一

医学のあゆみ 285 巻 ( 8 ) 頁： 755 - 756 2023年5月

Prognosis and incidence of infections in chronic kidney disease patients with membranous nephropathy enrolled in a large Japanese clinical claims database 査読有り Open Access

Matsuzaki, T; Watanabe, Y; Tanaka, A; Furuhashi, K; Saito, S; Maruyama, S

BMC NEPHROLOGY 24 巻 ( 1 ) 頁： 126 2023年5月

Excess risk of cardiovascular events in patients in the United States vs. Japan with chronic kidney disease is mediated mainly by left ventricular structure and function 査読有り Open Access

Imaizumi, T; Fujii, N; Hamano, T; Yang, W; Taguri, M; Kansal, M; Mehta, R; Shafi, T; Taliercio, J; Go, A; Rao, PDRA; Hamm, LL; Deo, R; Maruyama, S; Fukagawa, M; Feldman, HI

KIDNEY INTERNATIONAL 103 巻 ( 5 ) 頁： 949 - 961 2023年5月

Application of a scoring system in Japanese patients diagnosed with atypical hemolytic uremic syndrome to assess the relationship between the score and clinical responses to eculizumab 査読有り Open Access

Wada, H; Teranishi, H; Shimono, A; Kato, N; Maruyama, S; Matsumoto, M

THROMBOSIS JOURNAL 21 巻 ( 1 ) 頁： 43 2023年4月

Effect of Low-Density Lipoprotein Apheresis on Quality of Life in Patients with Diabetes, Proteinuria, and Hypercholesterolemia 査読有り

Hara, A; Wada, T; Muso, E; Maruyama, S; Kato, S; Furuichi, K; Yoshimura, K; Toyama, T; Sakai, N; Suzuki, H; Tsukamoto, T; Miyazaki, M; Sato, E; Abe, M; Shibagaki, Y; Narita, I; Goto, S; Sakamaki, Y; Yokoyama, H; Mori, N; Tanaka, S; Yuzawa, Y; Hasegawa, M; Matsubara, T; Wada, J; Tanabe, K; Masutani, K; Abe, Y; Tsuruya, K; Fujimoto, S; Iwatsubo, S; Tsuda, A; Suzuki, H; Kasuno, K; Terada, Y; Nakata, T; Iino, N; Sofue, T; Miyata, H; Nakano, T; Ohtake, T; Kobayashi, S

BLOOD PURIFICATION 52 巻 ( 4 ) 頁： 373 - 381 2023年4月

Prognostic factors of IgA nephropathy presenting with mild proteinuria at the time of diagnosis (a multicenter cohort study) 査読有り Open Access

Shirai, S; Yasuda, T; Kumagai, H; Matsunobu, H; Ichikawa, D; Shibagaki, Y; Yasuda, Y; Matsuzaki, K; Hirano, K; Kawamura, T; Suzuki, Y; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 27 巻 ( 4 ) 頁： 340 - 348 2023年4月

Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells 査読有り Open Access

Imai, K; Ishimoto, T; Doke, T; Tsuboi, T; Watanabe, Y; Katsushima, K; Suzuki, M; Oishi, H; Furuhashi, K; Ito, Y; Kondo, Y; Maruyama, S

MOLECULAR THERAPY NUCLEIC ACIDS 31 巻頁： 139 - 150 2023年3月

Serum and plasma levels of Ba, but not those of soluble C5b-9, might be affected by renal function in chronic kidney disease patients 査読有り Open Access

Yamane, R; Yasuda, Y; Oshima, A; Suzuki, Y; Kojima, H; Kim, H; Fukui, S; Maruyama, S; Ito, Y; Mizuno, M

BMC NEPHROLOGY 24 巻 ( 1 ) 頁： 26 2023年2月

Non-A Blood Type Is a Risk Factor for Poor Cardio-Cerebrovascular Outcomes in Patients Undergoing Dialysis 査読有り Open Access

Nakayama, T; Yamamoto, J; Ozeki, T; Tsuruta, Y; Yokoi, M; Aoi, T; Mori, Y; Hori, M; Tsujita, M; Shirasawa, Y; Kondo, C; Yasuda, K; Murata, M; Kinoshita, Y; Suzuki, S; Fukuda, M; Yamazaki, C; Ikehara, N; Sugiura, M; Goto, T; Hashimoto, H; Yajima, K; Maruyama, S; Morozumi, K; Seo, Y

BIOMEDICINES 11 巻 ( 2 ) 頁： 592 2023年2月

Assessment of Antibody-Titer Changes after Second and Third Severe Acute Respiratory Syndrome Coronavirus 2 mRNA Vaccination in Japanese Post-Kidney-Transplant Patients 査読有り Open Access

Fujieda, K; Tanaka, A; Kikuchi, R; Takai, N; Saito, S; Yasuda, Y; Fujita, T; Kato, M; Furuhashi, K; Maruyama, S

VACCINES 11 巻 ( 1 ) 頁： 134 2023年1月

腎移植後ガンシクロビル耐性サイトメガロウイルス感染となった2例

佐野優太, 石田昇平, 佐野友康, 加藤真史, 田中章仁, 齋藤尚二, 安田宜成, 丸山彰一, 赤松秀輔

移植 58 巻 ( Supplement ) 頁： s274_2 - s274_2 2023年

記述言語：日本語出版者・発行元：一般社団法人日本移植学会

サイトメガロウイルス(CMV)感染症は最も頻度が高く重要な移植後ウイルス感染症である。治療にはまずガンシクロビル(GCV)、バルガンシクロビル(VGCV)が使用されるが、今回移植後GCV耐性CMV感染となり、ホスカルネットナトリウムにて治癒した2例を経験したので報告する。症例1:50代男性。X-17年より血液透析導入。Caroli病による頻回の胆管炎で入院を繰り返していた。ドナーは50代女性。原疾患は脳出血。脳死下肝腎同時移植施行。S-Cre1.00mg/dl前後で安定し、特記合併症なく術後約一か月で退院となった。CMV抗体陽性。術後7か月後、CMV感染となりVGCV内服開始。内服開始後もCMV感染の改善見られず、GCV耐性が判明しホスカルネットナトリウム投与開始。特記合併症なく治癒した。症例2:40代男性。X年、悪性高血圧による慢性腎不全にて血液透析導入。母親をドナーとした生体腎移植施行。S-Cre2.00mg/dl前後で安定し、特記合併症なく術後約一か月で退院となった。レシピエントCMV抗体陰性、ドナーCMV抗体陽性であったためVGCV予防内服を開始した。術後6か月後、CMV感染となりVGCV内服を治療量へ増やした。内服開始後もCMV感染の改善見られず、GCV耐性が判明しホスカルネットナトリウム投与開始。特記合併症なく治癒した。今回、移植後GCV耐性CMVに対してホスカルネットナトリムを使用し、特記問題なく治癒した症例を経験したので若干の文献的考察を加えて報告する。

DOI： 10.11386/jst.58.supplement_s274_2

CiNii Research

生体腎移植ドナーにおける腎提供後のフォローアップの重要性

安田宜成, 田中章仁, 齋藤尚二, 加藤規利, 小杉智規, 佐野優太, 加藤真史, 丸山彰一

移植 58 巻 ( Supplement ) 頁： s248_3 - s248_3 2023年

記述言語：日本語出版者・発行元：一般社団法人日本移植学会

【目的】日本透析医学会の統計調査では慢性維持透析患者107 人（0.043％）が腎移植ドナーとしての腎提供ありと回答した。名古屋大学の生体腎移植ドナーの予後を調査した。【方法】対象は1998年以降に名古屋大学で生体腎移植のため腎提供したドナー167名。内2020～22年に受診した138名の最終診察時のCKD重症度分類を調査した。受診がない29名について背景を調査した。【結果】生体腎移植ドナーのGFR区分はG2:18名（13.0％）、G3a:74名（53.6％）、G3b:44名（31.9％）G4:2名（1.5％）、蛋白尿区分はA1:103名（74.6％）、A2:25名（18.1％）、A3:5名（3.6％）、未測定5名（3.6％）であった。G4の1名は73歳男性で腎提供前の2回の実測Ｃｃｒ平均は126.15ｍＬ/分であったが腎提供後に高血圧を合併し、腎提供後15年以上の経過で大動脈瘤手術を受けていた。残る1名は80歳女性で腎提供前の実測GFRは113.9で、腎提供後も10年以上安定していたが、急性腎障害後に腎機能が低下した。A3の4名では、腎提供前の高血圧合併2名、肥満1名だった。

DOI： 10.11386/jst.58.supplement_s248_3

CiNii Research

Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury Due to Unexpected Drug Abuse Open Access

Sato, N; Inagaki, K; Takanashi, M; Muto, R; Kato, N; Maruyama, S; Akahori, T

INTERNAL MEDICINE 62 巻 ( 19 ) 頁： 2865 - 2870 2023年

Recurrent Cerebrovascular Complications under Enzyme Replacement Therapy in a Patient with Fabry Disease on Peritoneal Dialysis Open Access

Muto, R; Suzuki, Y; Shimizu, H; Yasuda, K; Ishimoto, T; Maruyama, S; Ito, Y; Mizuno, M

INTERNAL MEDICINE 62 巻 ( 3 ) 頁： 565 - 569 2023年

The Impact of Liver Chemistries on Respiratory Failure among Hemodialysis Patients with COVID-19 during the Omicron Wave Open Access

Hori, M; Yasuda, K; Takahashi, H; Aoi, T; Mori, Y; Tsujita, M; Shirasawa, Y; Kondo, C; Hashimoto, T; Koyama, H; Morozumi, K; Maruyama, S

INTERNAL MEDICINE 62 巻 ( 18 ) 頁： 2617 - 2625 2023年

Long-term peritoneal dialysate exposure modulates expression of membrane complement regulators in human peritoneal mesothelial cells 査読有り Open Access

Kobayashi, K; Ozeki, T; Kim, H; Imai, M; Kojima, H; Iguchi, D; Fukui, S; Suzuki, M; Suzuki, Y; Maruyama, S; Ito, Y; Mizuno, M

FRONTIERS IN MEDICINE 9 巻頁： 972592 2022年12月

Deep learning analysis of clinical course of primary nephrotic syndrome: Japan Nephrotic Syndrome Cohort Study (JNSCS) 査読有り Open Access

Kimura, T; Yamamoto, R; Yoshino, M; Sakate, R; Imai, E; Maruyama, S; Yokoyama, H; Sugiyama, H; Nitta, K; Tsukamoto, T; Uchida, S; Takeda, A; Sato, T; Wada, T; Hayashi, H; Akai, Y; Fukunaga, M; Tsuruya, K; Masutani, K; Konta, T; Shoji, T; Hiramatsu, T; Goto, S; Tamai, H; Nishio, S; Nagai, K; Yamagata, K; Yasuda, H; Ichida, S; Naruse, T; Nishino, T; Sobajima, H; Akahori, T; Ito, T; Terada, Y; Katafuchi, R; Fujimoto, S; Okada, H; Mimura, T; Suzuki, S; Saka, Y; Sofue, T; Kitagawa, K; Fujita, Y; Mizutani, M; Kashihara, N; Sato, H; Narita, I; Isaka, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 26 巻 ( 12 ) 頁： 1170 - 1179 2022年12月

Predicting oxygen requirements in patients with coronavirus disease 2019 using an artificial intelligence-clinician model based on local non-image data 査読有り Open Access

Muto, R; Fukuta, S; Watanabe, T; Shindo, Y; Kanemitsu, Y; Kajikawa, S; Yonezawa, T; Inoue, T; Ichihashi, T; Shiratori, Y; Maruyama, S

FRONTIERS IN MEDICINE 9 巻頁： 1042067 2022年11月

Systematic characterization of seed overlap microRNA cotargeting associated with lupus pathogenesis 査読有り Open Access

Kitai, H; Kato, N; Ogami, K; Komatsu, S; Watanabe, Y; Yoshino, S; Koshi, E; Tsubota, S; Funahashi, Y; Maeda, T; Furuhashi, K; Ishimoto, T; Kosugi, T; Maruyama, S; Kadomatsu, K; Suzuki, H

BMC BIOLOGY 20 巻 ( 1 ) 頁： 248 2022年11月

Influence of COVID-19 on the 10-year carbon footprint of the Nagoya University Hospital and medical research centre 査読有り Open Access

Morooka, H; Yamamoto, T; Tanaka, A; Furuhashi, K; Miyagawa, Y; Maruyama, S

GLOBALIZATION AND HEALTH 18 巻 ( 1 ) 頁： 92 2022年11月

Identifying high-risk population of depression: association between metabolic syndrome and depression using a health checkup and claims database 査読有り Open Access

Imaizumi, T; Toda, T; Maekawa, M; Sakurai, D; Hagiwara, Y; Yoshida, Y; Ando, M; Maruyama, S

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 18577 2022年11月

Impact of Urinary Protein Examination on Early Diagnosis of CKD: A Nationwide Hospital-Based Observational Study in Japan, REAL-CKD

Maruyama, S; Tanaka, T; Takeda, M; Morita, N; Yajima, T

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 33 巻 ( 11 ) 頁： 301 - 301 2022年11月

Acute Kidney Injury and Remission of Proteinuria in Minimal Change Disease 査読有り Open Access

Yamamoto, R; Imai, E; Maruyama, S; Yokoyama, H; Sugiyama, H; Takeda, A; Uchida, S; Tsukamoto, T; Tsuruya, K; Akai, Y; Nitta, K; Fukunaga, M; Hayashi, H; Shoji, T; Masutani, K; Konta, T; Katafuchi, R; Nishio, S; Wada, T; Goto, S; Tamai, H; Shirasaki, A; Nagai, K; Nishino, T; Yamagata, K; Kazama, JJ; Hiromura, K; Yasuda, H; Sofue, T; Fujimoto, S; Mizutani, M; Naruse, T; Hiramatsu, T; Morozumi, K; Sobajima, H; Saka, Y; Ishimura, E; Ito, T; Ichikawa, D; Shigematsu, T; Sato, H; Narita, I; Yoshitaka, I

KIDNEY INTERNATIONAL REPORTS 7 巻 ( 10 ) 頁： 2283 - 2288 2022年10月

A nationwide analysis of renal and patient outcomes for adults with lupus nephritis in Japan 査読有り

Ikeuchi, H; Sugiyama, H; Sato, H; Yokoyama, H; Maruyama, S; Mukoyama, M; Hayashi, H; Tsukamoto, T; Fukuda, M; Yamagata, K; Ishikawa, E; Uchida, K; Kamijo, Y; Nakagawa, N; Tsuruya, K; Nojima, Y; Hiromura, K

CLINICAL AND EXPERIMENTAL NEPHROLOGY 26 巻 ( 9 ) 頁： 898 - 908 2022年9月

New-onset and relapse of nephrotic syndrome following COVID-19 vaccination: a questionnaire survey in Japan 査読有り Open Access

Nakagawa, N; Maruyama, S; Kashihara, N; Narita, I; Isaka, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 26 巻 ( 9 ) 頁： 909 - 916 2022年9月

Impact of etelcalcetide on fibroblast growth factor-23 and calciprotein particles in patients with secondary hyperparathyroidism undergoing haemodialysis 査読有り Open Access

Hashimoto, Y; Kato, S; Kuro-o, M; Miura, Y; Itano, Y; Ando, M; Kuwatsuka, Y; Maruyama, S

NEPHROLOGY 27 巻 ( 9 ) 頁： 763 - 770 2022年9月

Mesenchymal stem cells exert renoprotection via extracellular vesicle-mediated modulation of M2 macrophages and spleen-kidney network 査読有り Open Access

Shimamura, Y; Furuhashi, K; Tanaka, A; Karasawa, M; Nozaki, T; Komatsu, S; Watanabe, K; Shimizu, A; Minatoguchi, S; Matsuyama, M; Sawa, Y; Tsuboi, N; Ishimoto, T; Suzuki, H; Maruyama, S

COMMUNICATIONS BIOLOGY 5 巻 ( 1 ) 頁： 753 2022年7月

Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study 査読有り Open Access

Yamamoto, R; Imai, E; Maruyama, S; Yokoyama, H; Sugiyama, H; Takeda, A; Uchida, S; Tsukamoto, T; Tsuruya, K; Akai, Y; Nitta, K; Fukunaga, M; Hayashi, H; Masutani, K; Wada, T; Konta, T; Katafuchi, R; Nishio, S; Goto, S; Tamai, H; Shirasaki, A; Shoji, T; Nagai, K; Nishino, T; Yamagata, K; Kazama, JJ; Hiromura, K; Yasuda, H; Mizutani, M; Naruse, T; Hiramatsu, T; Morozumi, K; Sobajima, H; Saka, Y; Ishimura, E; Ichikawa, D; Shigematsu, T; Sofue, T; Fujimoto, S; Ito, T; Sato, H; Narita, I; Isaka, Y

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 9782 2022年6月

Mortality and Cardiovascular Events in Patients With Chronic Kidney Disease and Sleep Apnea Syndrome Open Access

Watanabe, Y; Tanaka, A; Furuhashi, K; Saito, S; Maruyama, S

FRONTIERS IN MEDICINE 9 巻頁： 899359 2022年5月

Protocol for a Phase 1, Open-Label, Multiple-Center, Dose-Escalation Study to Evaluate the Safety and Tolerability of ADR-001 in the Treatment of Immunoglobulin A Nephropathy Open Access

Tanaka, A; Furuhashi, K; Fujieda, K; Maeda, K; Saito, S; Mimura, T; Saka, Y; Naruse, T; Ishimoto, T; Kosugi, T; Kinoshita, F; Kuwatsuka, Y; Shimizu, S; Nakai, Y; Maruyama, S

FRONTIERS IN MEDICINE 9 巻頁： 883168 2022年5月

Effects of bone turnover status on the efficacy and safety of denosumab among haemodialysis patients 査読有り Open Access

Hori, M; Yasuda, K; Takahashi, H; Kondo, C; Shirasawa, Y; Ishimaru, Y; Sekiya, Y; Morozumi, K; Maruyama, S

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 7781 2022年5月

Antibody response to double SARS-CoV-2 mRNA vaccination in Japanese kidney transplant recipients 査読有り Open Access

Fujieda, K; Tanaka, A; Kikuchi, R; Takai, N; Saito, S; Yasuda, Y; Fujita, T; Kato, M; Furuhashi, K; Maruyama, S

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 6850 2022年4月

Time to remission of proteinuria and incidence of relapse in patients with steroid-sensitive minimal change disease and focal segmental glomerulosclerosis: the Japan Nephrotic Syndrome Cohort Study. 査読有り

Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Takeda A, Tsukamoto T, Uchida S, Tsuruya K, Shoji T, Hayashi H, Akai Y, Fukunaga M, Konta T, Nishio S, Goto S, Tamai H, Nagai K, Katafuchi R, Masutani K, Wada T, Nishino T, Shirasaki A, Sobajima H, Nitta K, Yamagata K, Kazama JJ, Hiromura K, Yasuda H, Mizutani M, Akahori T, Naruse T, Hiramatsu T, Morozumi K, Mimura T, Saka Y, Ishimura E, Hasegawa H, Ichikawa D, Shigematsu T, Sato H, Narita I, Isaka Y, Japan Nephrotic Syndrome Cohort Study investigators.

J Nephrol 35 巻 ( 4 ) 頁： 1135 - 1144 2022年4月

A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts. 査読有り

Minatoguchi S, Saito S, Furuhashi K, Sawa Y, Okazaki M, Shimamura Y, Kaihan AB, Hashimoto Y, Yasuda Y, Hara A, Mizutani Y, Ando R, Kato N, Ishimoto T, Tsuboi N, Esaki N, Matsuyama M, Shiraki Y, Kobayashi H, Asai N, Enomoto A, Maruyama S

Sci Rep 12 巻 ( 1 ) 頁： 5389 2022年3月

Biopsy-proven CKD etiology and outcomes: Chronic Kidney Disease Japan Cohort (CKD-JAC) study. 査読有り

Hamano T, Imaizumi T, Hasegawa T, Fujii N, Komaba H, Ando M, Nangaku M, Nitta K, Hirakata H, Isaka Y, Wada T, Maruyama S, Fukagawa M

Nephrol Dial Transplant 38 巻 ( 2 ) 頁： 384 - 395 2022年3月

Lateral spine dual-energy X-ray absorptiometry and the risk of fragility fractures in long-term kidney graft recipients 査読有り

Hori Mayuko, Yasuda Kaoru, Takahashi Hiroshi, Matsuoka Yutaka, Tsujita Makoto, Nishihira Morikuni, Uchida Kazuharu, Morozumi Kunio, Maruyama Shoichi

Related information 26 巻 ( 7 ) 頁： 724 - 732 2022年3月

Impact of left ventricular hypertrophy on clinical outcomes in patients with dialysis: a single-center study in Japan 査読有り

Nakayama Takafumi, Yamamoto Junki, Ozeki Toshikazu, Yasuda Kaoru, Yamazaki Chikao, Ito Tsuyoshi, Goto Toshihiko, Maruyama Shoichi, Morozumi Kunio, Seo Yoshihiro

J Med Ultrason (2001) 49 巻 ( 2 ) 頁： 241 - 252 2022年3月

Long-term Effectiveness of a Primary Care Practice Facilitation Program for Chronic Kidney Disease Management: An Extended Follow-up of a Cluster-Randomized FROM-J Study. 査読有り

Imasawa T, Saito C, Kai H, Iseki K, Kazama JJ, Shibagaki Y, Sugiyama H, Nagata D, Narita I, Nishino T, Hasegawa H, Honda H, Maruyama S, Miyazaki M, Mukoyama M, Yasuda H, Wada T, Ishikawa Y, Tsunoda R, Nagai K, Okubo R, Kondo M, Hoshino J, Yamagata K

Nephrol Dial Transplant 38 巻 ( 1 ) 頁： 158 - 166 2022年2月

Clustering phosphate and iron-related markers and prognosis in dialysis patients 査読有り Open Access

Morooka, H; Tanaka, A; Inaguma, D; Maruyama, S

CLINICAL KIDNEY JOURNAL 15 巻 ( 2 ) 頁： 328 - 337 2022年2月

Favorable therapeutic efficacy of low-density lipoprotein apheresis for nephrotic syndrome with impaired renal function. 査読有り

Muso E, Sakai S, Ogura Y, Yukawa S, Nishizawa Y, Yorioka N, Saito T, Mune M, Sugiyama S, Iino Y, Hirano T, Hattori M, Watanabe T, Yokoyama H, Sato H, Uchida S, Wada T, Shoji T, Oda H, Mori K, Kimura H, Ito O, Nishiyama A, Maruyama S, Inagi R, Fujimoto S, Tsukamoto T, Suzuki Y, Honda H, Babazono T, Tsuruya K, Yuzawa Y

Ther Apher Dial 26 巻 ( 1 ) 頁： 220 - 228 2022年2月

Sex differences in clinical outcomes in Japanese incident dialysis patients: a prospective observational multicenter study 査読有り

Kozaki Yohei, Morinaga Takatoshi, Fukatsu Atsushi, Ito Takeshi, Ishimoto Takuji, Kosugi Tomoki, Inaguma Daijo, Tamai Hirofumi, Maruyama Shoichi

Clin Exp Nephrol 26 巻 ( 5 ) 頁： 466 - 475 2022年1月

Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones 査読有り

Nagano Fumihiko, Mizuno Tomohiro, Imai Masaki, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Mizuno Masashi

FEBS Open Bio 12 巻 ( 1 ) 頁： 192 - 202 2022年1月

Increased Monocyte/Lymphocyte Ratio as Risk Marker for Cardiovascular Events and Infectious Disease Hospitalization in Dialysis Patients. 査読有り

Muto R, Kato S, Lindholm B, Qureshi AR, Ishimoto T, Kosugi T, Maruyama S

Blood Purif 51 巻 ( 9 ) 頁： 747 - 755 2021年11月

The 30-year Natural History of Non-classic Fabry Disease with an R112H Mutation. 査読有り

Muto R, Inagaki K, Kato N, Maruyama S, Akahori T

Intern Med 61 巻 ( 11 ) 頁： 1727 - 1730 2021年11月

Kidney Outcomes Associated With SGLT2 Inhibitors Versus Other Glucose-Lowering Drugs in Real-world Clinical Practice: The Japan Chronic Kidney Disease Database. 査読有り

Nagasu H, Yano Y, Kanegae H, Heerspink HJL, Nangaku M, Hirakawa Y, Sugawara Y, Nakagawa N, Tani Y, Wada J, Sugiyama H, Tsuruya K, Nakano T, Maruyama S, Wada T, Yamagata K, Narita I, Tamura K, Yanagita M, Terada Y, Shigematsu T, Sofue T, Ito T, Okada H, Nakashima N, Kataoka H, Ohe K, Okada M, Itano S, Nishiyama A, Kanda E, Ueki K, Kashihara N

Diabetes Care 44 巻 ( 11 ) 頁： 2542 - 2551 2021年11月

X-chromosome inactivation patterns in females with Fabry disease examined by both ultra-deep RNA sequencing and methylation-dependent assay 査読有り

Rossanti Rini, Nozu Kandai, Fukunaga Atsushi, Nagano China, Horinouchi Tomoko, Yamamura Tomohiko, Sakakibara Nana, Minamikawa Shogo, Ishiko Shinya, Aoto Yuya, Okada Eri, Ninchoji Takeshi, Kato Noritoshi, Maruyama Shoichi, Kono Keiji, Nishi Shinichi, Iijima Kazumoto, Fujii Hideki

Clin Exp Nephrol 25 巻 ( 11 ) 頁： 1224 - 1230 2021年11月

Abnormal magnesium levels and their impact on death and acute kidney injury in critically ill children 査読有り

Morooka Hikaru, Tanaka Akihito, Kasugai Daisuke, Ozaki Masayuki, Numaguchi Atsushi, Maruyama Shoichi

Pediatr Nephrol 37 巻 ( 5 ) 頁： 1157 - 1165 2021年10月

Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis 査読有り Open Access

Ryuge, A; Kosugi, T; Maeda, K; Banno, R; Gou, Y; Zaitsu, K; Ito, T; Sato, Y; Hirayama, A; Tsubota, S; Honda, T; Nakajima, K; Ozaki, T; Kondoh, K; Takahashi, K; Kato, N; Ishimoto, T; Soga, T; Nakagawa, T; Koike, T; Arima, H; Yuzawa, Y; Minokoshi, Y; Maruyama, S; Kadomatsu, K

JCI INSIGHT 6 巻 ( 20 ) 頁： e142464 2021年10月

Effect of body mass index on the association between alcohol consumption and the development of chronic kidney disease 査読有り

Hashimoto Yusaku, Imaizumi Takahiro, Kato Sawako, Yasuda Yoshinari, Ishimoto Takuji, Kawashiri Hiroaki, Hori Akihiro, Maruyama Shoichi

Sci Rep 11 巻 ( 1 ) 頁： 20440 2021年10月

Epidemiology and temporal changes in the prognosis of rapidly progressive glomerulonephritis in Japan: a nationwide 1989-2015 survey 査読有り

Kaneko Shuzo, Yamagata Kunihiro, Usui Joichi, Tsuboi Naotake, Sugiyama Hitoshi, Maruyama Shoichi, Narita Ichiei

Clin Exp Nephrol 26 巻 ( 3 ) 頁： 234 - 246 2021年10月

Kidney biopsy guidebook 2020 in Japan (vol 25, pg 325, 2021) 査読有り

Ubara Yoshifumi, Kawaguchi Takehiko, Nagasawa Tasuku, Miura Kenichiro, Katsuno Takayuki, Morikawa Takashi, Ishikawa Eiji, Ogura Masao, Matsumura Hideki, Kurayama Ryota, Matsumoto Shinsuke, Marui Yuhji, Hara Shigeo, Maruyama Shoichi, Narita Ichiei, Okada Hirokazu, Tsuruya Kazuhiko

Clin Exp Nephrol 25 巻 ( 10 ) 頁： 1161 - 1161 2021年10月

Urinary Metabolome Analyses of Patients with Acute Kidney Injury Using Capillary Electrophoresis-Mass Spectrometry 査読有り

Saito Rintaro, Hirayama Akiyoshi, Akiba Arisa, Kamei Yushi, Kato Yuyu, Ikeda Satsuki, Kwan Brian, Pu Minya, Natarajan Loki, Shinjo Hibiki, Akiyama Shin'ichi, Tomita Masaru, Soga Tomoyoshi, Maruyama Shoichi

Metabolites 11 巻 ( 10 ) 頁： 671 2021年10月

The Alteration of Neutrophil Nuclear Morphology: A Potential Predictor for Corticosteroid Response in IgA Nephropathy

Muto, R; Kato, S; Maruyama, S

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 32 巻 ( 10 ) 頁： 821 - 821 2021年10月

Eculizumab for Treatment of Recurrent Pregnancy-Triggered Atypical Hemolytic-Uremic Syndrome with a Mutation in Complement 3: A Case Report

Miyabe, Y; Nakai, A; Watanabe, K; Karasawa, K; Kato, N; Maruyama, S; Moriyama, T; Nitta, K

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 32 巻 ( 10 ) 頁： 826 - 827 2021年10月

A Case of TAFRO Syndrome with Two Consecutive Renal Biopsies Following the Pathological Course of the Kidney

Kato, N; Hasegawa, T; Muto, R; Tanaka, A; Sato, Y; Maeda, K; Furuhashi, K; Saito, S; Kosugi, T; Maruyama, S

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 32 巻 ( 10 ) 頁： 823 - 824 2021年10月

Demographic, clinical characteristics and treatment outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulonephritis in Japan: A retrospective analysis of data from the Japan Renal Biopsy Registry 査読有り

Nakagawa Naoki, Mizuno Masashi, Kato Sawako, Maruyama Shoichi, Sato Hiroshi, Nakaya Izaya, Sugiyama Hitoshi, Fujimoto Shouichi, Miura Kenichiro, Matsumura Chieko, Gotoh Yoshimitsu, Suzuki Hitoshi, Kuroki Aki, Yoshino Atsunori, Nakatani Shinya, Hiromura Keiju, Yamamoto Ryohei, Yokoyama Hitoshi, Narita Ichiei, Isaka Yoshitaka

PLoS One 16 巻 ( 9 ) 頁： e0257397 2021年9月

Focal segmental glomerulosclerosis histologic variants and renal outcomes based on nephrotic syndrome, immunosuppression and proteinuria remission. 査読有り

Kawaguchi T, Imasawa T, Kadomura M, Kitamura H, Maruyama S, Ozeki T, Katafuchi R, Oka K, Isaka Y, Yokoyama H, Sugiyama H, Sato H

Nephrol Dial Transplant 37 巻 ( 9 ) 頁： 1679 - 1690 2021年9月

Factors predicting decline in renal function and kidney volume growth in autosomal dominant polycystic kidney disease: a prospective cohort study (Japanese Polycystic Kidney Disease registry: J-PKD) 査読有り

Uchiyama Kiyotaka, Mochizuki Toshio, Shimada Yosuke, Nishio Saori, Kataoka Hiroshi, Mitobe Michihiro, Tsuchiya Ken, Hanaoka Kazushige, Ubara Yoshifumi, Suwabe Tatsuya, Sekine Akinari, Nutahara Kikuo, Tsuruya Kazuhiko, Ishimura Eiji, Nakatani Shinya, Sofue Tadashi, Tanaka Satoshi, Narita Ichiei, Maruyama Shoichi, Horie Shigeo, Muto Satoru

Clin Exp Nephrol 25 巻 ( 9 ) 頁： 970 - 980 2021年9月

Roles of glomerular endothelial hyaluronan in the development of proteinuria 査読有り Open Access

Asai, A; Hatayama, N; Kamiya, K; Yamauchi, M; Kinashi, H; Yamaguchi, M; Katsuno, T; Nobata, H; Watanabe, K; Wakatsuki, A; Aten, J; Maruyama, S; Ishimoto, T; Hirai, S; Naito, M; Ito, Y

PHYSIOLOGICAL REPORTS 9 巻 ( 17 ) 頁： e15019 2021年9月

Low-GDP, pH-neutral solutions preserve peritoneal endothelial glycocalyx during long-term peritoneal dialysis 査読有り

Sugiyama Naoya, Tawada Mitsuhiro, Sun Ting, Suzuki Yasuhiro, Kinashi Hiroshi, Yamaguchi Makoto, Katsuno Takayuki, Aten Jan, Vlahu Carmen A., van Kuppevelt Toin H., Takei Yoshifumi, Ishimoto Takuji, Maruyama Shoichi, Mizuno Masashi, Ito Yasuhiko

Clin Exp Nephrol 25 巻 ( 9 ) 頁： 1035 - 1046 2021年9月

All-cause and cardiovascular mortality in patients undergoing hemodialysis with aortic sclerosis and mild-to-moderate aortic stenosis: A cohort study 査読有り

Kurasawa Shimon, Hishida Manabu, Imaizumi Takahiro, Okazaki Masaki, Nishibori Nobuhiro, Kondo Toru, Kasuga Hirotake, Maruyama Shoichi

Atherosclerosis 331 巻頁： 12 - 19 2021年8月

Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP(+) regulatory T cells 査読有り

Satoh Kazuki, Kobayashi Yoichi, Fujimaki Kaori, Hayashi Shinko, Ishida Saori, Sugiyama Daisuke, Sato Takahiko, Lim Kyungtaek, Miyamoto Megumi, Kozuma Shiho, Kadokura Michinori, Wakita Kenichi, Hata Masato, Hirahara Kazuki, Amano Masato, Watanabe Ichiro, Okamoto Atsushi, Tuettenberg Andrea, Jonuleit Helmut, Tanemura Atsushi, Maruyama Shoichi, Agatsuma Toshinori, Wada Teiji, Nishikawa Hiroyoshi

Int Immunol 33 巻 ( 8 ) 頁： 435 - 446 2021年8月

Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity 査読有り

Kobayashi Azusa, Ito Ayaka, Shirakawa Ibuki, Tamura Atsushi, Tomono Susumu, Shindou Hideo, Hedde Per Niklas, Tanaka Miyako, Tsuboi Naotake, Ishimoto Takuji, Akashi-Takamura Sachiko, Maruyama Shoichi, Suganami Takayoshi

Front Immunol 12 巻頁： 650856 2021年6月

C1 inhibitor mitigates peritoneal injury in zymosan-induced peritonitis 査読有り

Ozeki Toshikazu, Mizuno Masashi, Iguchi Daiki, Kojima Hiroshi, Kim Hangsoo, Suzuki Yasuhiro, Kinashi Hiroshi, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko

American journal of physiology. Renal physiology 320 巻 ( 6 ) 頁： F1123 - F1132 2021年6月

Impact of serum magnesium and bone mineral density on systemic fractures in chronic hemodialysis patients 査読有り

Hori Mayuko, Yasuda Kaoru, Takahashi Hiroshi, Yamazaki Chikao, Morozumi Kunio, Maruyama Shoichi

PLoS One 16 巻 ( 5 ) 頁： e0251912 2021年5月

Relationship between mortality and use of sodium bicarbonate at the time of dialysis initiation: a prospective observational study 査読有り Open Access

Morooka, H; Yamamoto, J; Tanaka, A; Inaguma, D; Maruyama, S

BMC NEPHROLOGY 22 巻 ( 1 ) 頁： 118 2021年4月

Efficacy of favipiravir for an end stage renal disease patient on maintenance hemodialysis infected with novel coronavirus disease 2019 査読有り Open Access

Koshi, E; Saito, S; Okazaki, M; Toyama, Y; Ishimoto, T; Kosugi, T; Hiraiwa, H; Jingushi, N; Yamamoto, T; Ozaki, M; Goto, Y; Numaguchi, A; Miyagawa, Y; Kato, I; Tetsuka, N; Yagi, T; Maruyama, S

CEN CASE REPORTS 10 巻 ( 1 ) 頁： 126 - 131 2021年2月

Relationship between selection of dosage forms of vitamin D receptor activators and short-term survival of patients on hemodialysis 査読有り

Koshi-Ito Eri, Inaguma Daijo, Koide Shigehisa, Takahashi Kazuo, Hayashi Hiroki, Tsuboi Naotake, Hasegawa Midori, Maruyama Shoichi, Yuzawa Yukio

Ren Fail 43 巻 ( 1 ) 頁： 1528 - 1538 2021年1月

Development of entrustable professional activities for residents rotating nephrology department in a Japanese university hospital: a Delphi study 査読有り

Tanaka Akihito, Kondo Takeshi, Urushibara-Miyachi Yuka, Maruyama Shoichi, Nishigori Hiroshi

BMJ Open 11 巻 ( 8 ) 頁： e047923 2021年

A nationwide cross-sectional analysis of thrombotic microangiopathy in the Japan Renal Biopsy Registry (J-RBR) 査読有り

Katsuno T, Ito Y, Kagami S, Kitamura H, Maruyama S, Shimizu A, Sugiyama H, Sato H, Yokoyama H, Kashihara N

Clin Exp Nephrol 24 巻 ( 9 ) 頁： 789 - 797 2020年9月

Additional prognostic value of toe-brachial index beyond ankle-brachial index in hemodialysis patients 査読有り Open Access

Hishida, M; Imaizumi, T; Menez, S; Okazaki, M; Akiyama, S; Kasuga, H; Ishigami, J; Maruyama, S; Matsushita, K

BMC NEPHROLOGY 21 巻 ( 1 ) 頁： 353 2020年8月

糸球体腎炎・ネフローゼ症候群の診断と治療の進歩

丸山彰一

日本内科学会雑誌 109 巻 ( 5 ) 頁： 877 - 880 2020年5月

Clinical Impact of Urinary CD11b and CD163 on the Renal Outcomes of Anti-neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis 査読有り

Yokoe Y, Tsuboi N, Imaizumi T, Kitagawa A, Karasawa M, Ozeki T, Endo N, Sawa Y, Kato S, Katsuno T, Maruyama S, Yamagata K, Usui J, Nagata M, Sada KE, Sugiyama H, Amano K, Arimura Y, Atsumi T, Yuzawa Y, Dobashi H, Takasaki Y, Harigai M, Hasegawa H, Makino H, Matsuo S

Nephrol Dial Transplant. 36 巻 ( 8 ) 頁： 1452 - 1463 2020年

Chronological change of renal pathological findings in the proliferative glomerulonephritis with monoclonal IgG deposits considered to have recurred early after kidney transplantation. 査読有り

Katsuno T, Kato M, Fujita T, Tsuboi N, Hattori R, Ito Y, Maruyama S

CEN case reports 8 巻 ( 3 ) 頁： 151 - 158 2019年8月

Clinical impact of endocapillary proliferation with modified cutoff points in IgA nephropathy patients 査読有り Open Access

Kaihan, AB; Yasuda, Y; Imaizumi, T; Inagaki, K; Ozeki, T; Hishida, M; Katsuno, T; Tsuboi, N; Maruyama, S

PLOS ONE 14 巻 ( 3 ) 頁： e0214414 2019年3月

Urinary levels of the leukocyte surface molecule CD11b associate with glomerular inflammation in lupus nephritis 査読有り Open Access

Kitagawa, A; Tsuboi, N; Yokoe, Y; Katsuno, T; Ikeuchi, H; Kajiyama, H; Endo, N; Sawa, Y; Suwa, J; Sugiyama, Y; Hachiya, A; Mimura, T; Hiromura, K; Maruyama, S

KIDNEY INTERNATIONAL 95 巻 ( 3 ) 頁： 680 - 692 2019年3月

Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study 査読有り Open Access

Katsuno, T; Masuda, T; Saito, S; Kato, N; Ishimoto, T; Kato, S; Kosugi, T; Tsuboi, N; Kitamura, H; Tsuzuki, T; Ito, Y; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 23 巻 ( 2 ) 頁： 207 - 214 2019年2月

Safety and effectiveness of eculizumab for pediatric patients with atypical hemolytic-uremic syndrome in Japan: interim analysis of post-marketing surveillance 査読有り Open Access

Ito, S; Hidaka, Y; Inoue, N; Kaname, S; Kato, H; Matsumoto, M; Miyakawa, Y; Mizuno, M; Okada, H; Shimono, A; Matsuda, T; Maruyama, S; Fujimura, Y; Nangaku, M; Kagami, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 23 巻 ( 1 ) 頁： 112 - 121 2019年1月

Differences in peritoneal solute transport rates in peritoneal dialysis 査読有り

Asano, M; Ishii, T; Hirayama, A; Mizuno, M; Suzuki, Y; Sakata, F; Akiyama, S; Maruyama, S; Soga, T; Kinashi, H; Katsuno, T; Ito, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 23 巻 ( 1 ) 頁： 122 - 134 2019年1月

Safety and effectiveness of eculizumab for adult patients with atypical hemolytic-uremic syndrome in Japan: interim analysis of post-marketing surveillance 査読有り Open Access

Kato, H; Miyakawa, Y; Hidaka, Y; Inoue, N; Ito, S; Kagami, S; Kaname, S; Matsumoto, M; Mizuno, M; Matsuda, T; Shimono, A; Maruyama, S; Fujimura, Y; Nangaku, M; Okada, H

CLINICAL AND EXPERIMENTAL NEPHROLOGY 23 巻 ( 1 ) 頁： 65 - 75 2019年1月

Anti-C5a complementary peptide mitigates zymosan-induced severe peritonitis with fibrotic encapsulation in rats pretreated with methylglyoxal 査読有り Open Access

Iguchi, D; Mizuno, M; Suzuki, Y; Sakata, F; Maruyama, S; Okada, A; Okada, H; Ito, Y

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 315 巻 ( 6 ) 頁： F1732 - F1746 2018年12月

Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial 査読有り Open Access

Kimura, K; Hosoya, T; Uchida, S; Inaba, M; Makino, H; Maruyama, S; Ito, S; Yamamoto, T; Tomino, Y; Ohno, I; Shibagaki, Y; Iimuro, S; Imai, N; Kuwabara, M; Hayakawa, H; Ohtsu, H; Ohashi, Y

AMERICAN JOURNAL OF KIDNEY DISEASES 72 巻 ( 6 ) 頁： 798 - 810 2018年12月

Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis 査読有り Open Access

Katsuno, T; Ozaki, T; Ozeki, T; Hachiya, A; Kim, H; Kato, N; Ishimoto, T; Kato, S; Kosugi, T; Tsuboi, N; Mizuno, M; Ito, Y; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 22 巻 ( 6 ) 頁： 1341 - 1350 2018年12月

Chronic Inflammatory Demyelinating Polyneuropathy With Concurrent Membranous Nephropathy: An Anti-paranode and Podocyte Protein Antibody Study and Literature Survey 査読有り Open Access

Hashimoto, Y; Ogata, H; Yamasaki, R; Sasaguri, T; Ko, S; Yamashita, K; Xu, Z; Matsushita, T; Tateishi, T; Akiyama, S; Maruyama, S; Yamamoto, A; Kira, J

FRONTIERS IN NEUROLOGY 9 巻頁： 997 2018年11月

Thrombotic microangiopathy on kidney biopsy in a patient with TAFRO syndrome. 査読有り

Ozeki T, Tsuji M, Yamamoto J, Shigematsu C, Maruyama S

CEN case reports 7 巻 ( 2 ) 頁： 243 - 247 2018年11月

Renoprotective effects of topiroxostat for Hyperuricaemic patients with overt diabetic nephropathy study (ETUDE study): A prospective, randomized, multicentre clinical trial 査読有り Open Access

Mizukoshi, T; Kato, S; Ando, M; Sobajima, H; Ohashi, N; Naruse, T; Saka, Y; Shimizu, H; Nagata, T; Maruyama, S

NEPHROLOGY 23 巻 ( 11 ) 頁： 1023 - 1030 2018年11月

Smoking Is a Risk Factor for Relapse of Antimyeloperoxidase Antibodies-Associated Vasculitis 査読有り

Yamaguchi, M; Ando, M; Katsuno, T; Tsuboi, N; Maruyama, S

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY 24 巻 ( 7 ) 頁： 361 - 367 2018年10月

Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cell, but not Adipose Tissue-Derived Stem Cell, Ameliorated the Neonatal Hypoxic-Ischemic Brain Injury by Changing Cerebral Inflammatory State in Rat 査読有り Open Access

Sugiyama, Y; Sato, Y; Kitase, Y; Suzuki, T; Kondo, T; Mikrogeorgiou, A; Horinouchi, A; Maruyama, S; Shimoyama, Y; Tsuji, M; Suzuki, S; Yamamoto, T; Hayakawa, M

FRONTIERS IN NEUROLOGY 9 巻頁： 757 2018年9月

Clinical impact of endocapillary proliferation according to the Oxford classification among adults with Henoch- Schonlein purpura nephritis: a multicenter retrospective cohort study 査読有り Open Access

Inagaki, K; Kaihan, AB; Hachiya, A; Ozeki, T; Ando, M; Kato, S; Yasuda, Y; Maruyama, S

BMC NEPHROLOGY 19 巻 ( 1 ) 頁： 208 2018年8月

CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease 査読有り Open Access

Maeda, K; Otomo, K; Yoshida, N; Abu-Asab, MS; Ichinose, K; Nishino, T; Kono, M; Ferretti, A; Bhargava, R; Maruyama, S; Bickerton, S; Fahmy, TM; Tsokos, MG; Tsokos, GC

JOURNAL OF CLINICAL INVESTIGATION 128 巻 ( 8 ) 頁： 3445 - 3459 2018年8月

The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases 査読有り Open Access

Mori, Y; Masuda, T; Kosugi, T; Yoshioka, T; Hori, M; Nagaya, H; Maeda, K; Sato, Y; Kojima, H; Kato, N; Ishimoto, T; Katsuno, T; Yuzawa, Y; Kadomatsu, K; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 22 巻 ( 4 ) 頁： 815 - 824 2018年8月

Clinical features and pathogenesis of membranoproliferative glomerulonephritis: a nationwide analysis of the Japan renal biopsy registry from 2007 to 2015 査読有り Open Access

Nakagawa, N; Hasebe, N; Hattori, M; Nagata, M; Yokoyama, H; Sato, H; Sugiyama, H; Shimizu, A; Isaka, Y; Maruyama, S; Narita, I

CLINICAL AND EXPERIMENTAL NEPHROLOGY 22 巻 ( 4 ) 頁： 797 - 807 2018年8月

A consensus statement on health-care transition of patients with childhood-onset chronic kidney diseases: providing adequate medical care in adolescence and young adulthood 査読有り Open Access

Kubota, W; Honda, M; Okada, H; Hattori, M; Iwano, M; Akioka, Y; Ashida, A; Kawasaki, Y; Kiyomoto, H; Sako, M; Terada, Y; Hirano, D; Fujieda, M; Fujimoto, S; Masaki, T; Ito, S; Uemura, O; Gotoh, Y; Komatsu, Y; Nishi, S; Maru, M; Narita, I; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 22 巻 ( 4 ) 頁： 743 - 751 2018年8月

Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice 査読有り Open Access

Doke, T; Ishimoto, T; Hayasaki, T; Ikeda, S; Hasebe, M; Hirayama, A; Soga, T; Kato, N; Kosugi, T; Tsuboi, N; Lanaspa, MA; Johnson, RJ; Kadomatsu, K; Maruyama, S

METABOLISM-CLINICAL AND EXPERIMENTAL 85 巻頁： 161 - 170 2018年8月

Urinary protein and renal prognosis in idiopathic membranous nephropathy: a multicenter retrospective cohort study in Japan 査読有り Open Access

Yamaguchi, M; Ando, M; Katsuno, T; Tsuboi, N; Maruyama, S

RENAL FAILURE 40 巻 ( 1 ) 頁： 435 - 441 2018年7月

Treatment patterns and steroid dose for adult minimal change disease relapses: A retrospective cohort study 査読有り Open Access

Ozeki, T; Ando, M; Yamaguchi, M; Katsuno, T; Kato, S; Yasuda, Y; Tsuboi, N; Maruyama, S

PLOS ONE 13 巻 ( 6 ) 頁： e0199228 2018年6月

Rationale and study design of a clinical trial to assess the effects of LDL apheresis on proteinuria in diabetic patients with severe proteinuria and dyslipidemia 査読有り

Wada Takashi, Muso Eri, Maruyama Shoichi, Hara Akinori, Furuichi Kengo, Yoshimura Kenichi, Miyazaki Mariko, Sato Eiichi, Abe Masanori, Shibagaki Yugo, Narita Ichiei, Yokoyama Hitoshi, Mori Noriko, Yuzawa Yukio, Matsubara Takeshi, Tsukamoto Tatsuo, Wada Jun, Ito Takafumi, Masutani Kosuke, Tsuruya Kazuhiko, Fujimoto Shoichi, Tsuda Akihiro, Suzuki Hitoshi, Kasuno Kenji, Terada Yoshio, Nakata Takeshi, Iino Noriaki, Kobayashi Shuzo

CLINICAL AND EXPERIMENTAL NEPHROLOGY 22 巻 ( 3 ) 頁： 591 - 596 2018年6月

Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schonlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registry (J-RBR) 査読有り Open Access

Komatsu, H; Fujimoto, S; Maruyama, S; Mukoyama, M; Sugiyama, H; Tsuruya, K; Sato, H; Soma, J; Yano, J; Itano, S; Nishino, T; Sato, T; Narita, I; Yokoyama, H

PLOS ONE 13 巻 ( 5 ) 頁： e0196955 2018年5月

Chondroitin sulfate protects vascular endothelial cells from toxicities of extracellular histones 査読有り

Nagano, F; Mizuno, T; Mizumoto, S; Yoshioka, K; Takahashi, K; Tsuboi, N; Maruyama, S; Yamada, S; Nagamatsu, T

EUROPEAN JOURNAL OF PHARMACOLOGY 826 巻頁： 48 - 55 2018年5月

Lifestyle intervention using Internet of Things (IoT) for the elderly: A study protocol for a randomized control trial (the BEST-LIFE study) 査読有り Open Access

Kato, S; Ando, M; Kondo, T; Yoshida, Y; Honda, H; Maruyama, S

NAGOYA JOURNAL OF MEDICAL SCIENCE 80 巻 ( 2 ) 頁： 175 - 182 2018年5月

Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS 査読有り

Shimizu, M; Furuichi, K; Toyama, T; Funamoto, T; Kitajima, S; Hara, A; Ogawa, D; Koya, D; Ikeda, K; Koshino, Y; Kurokawa, Y; Abe, H; Mori, K; Nakayama, M; Konishi, Y; Samejima, Ki; Matsui, M; Yamauchi, H; Gohda, T; Fukami, K; Nagata, D; Yamazaki, H; Yuzawa, Y; Suzuki, Y; Fujimoto, S; Maruyama, S; Kato, S; Naito, T; Yoshimura, K; Yokoyama, H; Wada, T

CLINICAL AND EXPERIMENTAL NEPHROLOGY 22 巻 ( 2 ) 頁： 377 - 387 2018年4月

Unfavorable effects of history of volume overload and late referral to a nephrologist on mortality in patients initiating dialysis: a multicenter prospective cohort study in Japan 査読有り Open Access

Okazaki, M; Inaguma, D; Imaizumi, T; Kada, A; Yaomura, T; Tsuboi, N; Maruyama, S

BMC NEPHROLOGY 19 巻 ( 1 ) 頁： 65 2018年3月

TGF-β1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis 査読有り

Kariya, T; Nishimura, H; Mizuno, M; Suzuki, Y; Matsukawa, Y; Sakata, F; Maruyama, S; Takei, Y; Ito, Y

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 314 巻 ( 2 ) 頁： F167 - F180 2018年2月

Rationale and design of oBservational clinical Research In chronic kidney disease patients with renal anemia: renal proGnosis in patients with Hyporesponsive anemia To Erythropoiesis-stimulating agents, darbepoetiN alfa (BRIGHTEN Trial) 査読有り Open Access

Kato, H; Nangaku, M; Hirakata, H; Wada, T; Hayashi, T; Sato, H; Yamazaki, Y; Masaki, T; Kagimura, T; Yamamoto, H; Hase, H; Kamouchi, M; Imai, E; Mizuno, K; Iwasaki, M; Akizawa, T; Tsubakihara, Y; Maruyama, S; Narita, I

CLINICAL AND EXPERIMENTAL NEPHROLOGY 22 巻 ( 1 ) 頁： 78 - 84 2018年2月

CLINICAL AND EXPERIMENTAL NEPHROLOGY 22 巻 ( 1 ) 頁： 85 - 86 2018年2月

Effect of dietary energy and polymorphisms in &ITBRAP&IT and &ITGHRL&IT on obesity and metabolic traits 査読有り

Imaizumi, T; Ando, M; Nakatochi, M; Yasuda, Y; Honda, H; Kuwatsuka, Y; Kato, S; Kondo, T; Iwata, M; Nakashima, T; Yasui, H; Takamatsu, H; Okajima, H; Yoshida, Y; Maruyama, S

OBESITY RESEARCH & CLINICAL PRACTICE 12 巻 ( 1 ) 頁： 39 - 48 2018年1月

Urinary and circulating levels of the anti-angiogenic isoform of vascular endothelial growth factor-A in patients with chronic kidney disease 査読有り

Kikuchi, R; Yasuda, Y; Nakatochi, M; Shibata, Y; Hara, T; Suzuki, A; Imaizumi, T; Suzuki, S; Ishii, H; Takeshita, K; Matsushita, T; Maruyama, S; Murohara, T

CLINICA CHIMICA ACTA 475 巻頁： 102 - 108 2017年12月

The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients 査読有り

Kaihan, AB; Yasuda, Y; Katsuno, T; Kato, S; Imaizumi, T; Ozeki, T; Hishida, M; Nagata, T; Ando, M; Tsuboi, N; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 21 巻 ( 6 ) 頁： 986 - 994 2017年12月

Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome 査読有り Open Access

Saito, T; Iwano, M; Matsumoto, K; Mitarai, T; Yokoyama, H; Yorioka, N; Nishi, S; Yoshimura, A; Sato, H; Ogahara, S; Sasatomi, Y; Kataoka, Y; Ueda, S; Koyama, A; Maruyama, S; Nangaku, M; Imai, E; Matsuo, S; Tomino, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 21 巻 ( 6 ) 頁： 961 - 970 2017年12月

Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission 査読有り Open Access

Inagaki, K; Yasuda, Y; Ando, M; Kaihan, AB; Hachiya, A; Ozeki, T; Hishida, M; Imaizumi, T; Katsuno, T; Kato, S; Tsuboi, N; Maruyama, S

PLOS ONE 12 巻 ( 11 ) 頁： e0187607 2017年11月

Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers 査読有り Open Access

Kubo, Y; Imaizumi, T; Ando, M; Nakatochi, M; Yasuda, Y; Honda, H; Kuwatsuka, Y; Kato, S; Kikuchi, K; Kondo, T; Iwata, M; Nakashima, T; Yasui, H; Takamatsu, H; Okajima, H; Yoshida, Y; Maruyama, S

PLOS ONE 12 巻 ( 10 ) 頁： e0185476 2017年10月

Efficacy of urinary midkine as a biomarker in patients with acute kidney injury 査読有り Open Access

Hayashi, H; Sato, W; Kosugi, T; Nishimura, K; Sugiyama, D; Asano, N; Ikematsu, S; Komori, K; Nishiwaki, K; Kadomatsu, K; Matsuo, S; Maruyama, S; Yuzawa, Y

CLINICAL AND EXPERIMENTAL NEPHROLOGY 21 巻 ( 4 ) 頁： 597 - 607 2017年8月

Randomized controlled trial for assessment of Internet of Things system to guide intensive glucose control in diabetes outpatients: Nagoya Health Navigator Study protocol 査読有り Open Access

Onoue, T; Goto, M; Kobayashi, T; Tominaga, T; Ando, M; Honda, H; Yoshida, Y; Tosaki, T; Yokoi, H; Kato, S; Maruyama, S; Arima, H

NAGOYA JOURNAL OF MEDICAL SCIENCE 79 巻 ( 3 ) 頁： 323 - 329 2017年8月

Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice 査読有り Open Access

Yashima, A; Mizuno, M; Yuzawa, Y; Shimada, K; Suzuki, N; Tawada, H; Sato, W; Tsuboi, N; Maruyama, S; Ito, Y; Matsuo, S; Ohno, T

CLINICAL AND EXPERIMENTAL NEPHROLOGY 21 巻 ( 4 ) 頁： 589 - 596 2017年8月

Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice 査読有り Open Access

Tomita, T; Arai, S; Kitada, K; Mizuno, M; Suzuki, Y; Sakata, F; Nakano, D; Hiramoto, E; Takei, Y; Maruyama, S; Nishiyama, A; Matsuo, S; Miyazaki, T; Ito, Y

SCIENTIFIC REPORTS 7 巻 ( 1 ) 頁： 6450 2017年7月

Long-term renal survival of γ3-heavy chain deposition disease: a case report 査読有り Open Access

Katsuno, T; Mizuno, S; Mabuchi, M; Tsuboi, N; Komatsuda, A; Maruyama, S

BMC NEPHROLOGY 18 巻 ( 1 ) 頁： 239 2017年7月

Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers 査読有り

Imaizumi, T; Ando, M; Nakatochi, M; Maruyama, S; Yasuda, Y; Honda, H; Kuwatsuka, Y; Kato, S; Kondo, T; Iwata, M; Nakashima, T; Yasui, H; Takamatsu, H; Okajima, H; Yoshida, Y; Matsuo, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 21 巻 ( 3 ) 頁： 457 - 464 2017年6月

Sodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice 査読有り Open Access

Sakata, F; Ito, Y; Mizuno, M; Sawai, A; Suzuki, Y; Tomita, T; Tawada, M; Tanaka, A; Hirayama, A; Sagara, A; Wada, T; Maruyama, S; Soga, T; Matsuo, S; Imai, E; Takei, Y

LABORATORY INVESTIGATION 97 巻 ( 4 ) 頁： 432 - 446 2017年4月

Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis 査読有り Open Access

Masuda, T; Maeda, K; Sato, W; Kosugi, T; Sato, Y; Kojima, H; Kato, N; Ishimoto, T; Tsuboi, N; Uchimura, K; Yuzawa, Y; Maruyama, S; Kadomatsu, K

AMERICAN JOURNAL OF PATHOLOGY 187 巻 ( 4 ) 頁： 740 - 751 2017年4月

Postpartum atypical hemolytic uremic syndrome with complement factor H mutation complicated by reversible cerebrovascular constriction syndrome successfully treated with eculizumab 査読有り

Yamaguchi, M; Hori, M; Hiroshi, N; Maruyama, S

THROMBOSIS RESEARCH 151 巻頁： 79 - 81 2017年3月

Complement component 5 promotes lethal thrombosis 査読有り Open Access

Mizuno, T; Yoshioka, K; Mizuno, M; Shimizu, M; Nagano, F; Okuda, T; Tsuboi, N; Maruyama, S; Nagamatsu, T; Imai, M

SCIENTIFIC REPORTS 7 巻頁： 42714 2017年2月

High Levels of Soluble C5b-9 Complex in Dialysis Fluid May Predict Poor Prognosis in Peritonitis in Peritoneal Dialysis Patients 査読有り Open Access

Mizuno, M; Suzuki, Y; Higashide, K; Sei, Y; Iguchi, D; Sakata, F; Horie, M; Maruyama, S; Matsuo, S; Morgan, BP; Ito, Y

PLOS ONE 12 巻 ( 1 ) 頁： e0169111 2017年1月

The Type of Vascular Access and the Incidence of Mortality in Japanese Dialysis Patients 査読有り

Ozeki Toshikazu, Shimizu Hideaki, Fujita Yoshiro, Inaguma Daijo, Maruyama Shoichi, Ohyama Yukako, Minatoguchi Shun, Murai Yukari, Terashita Maho, Tagaya Tomoki

Internal Medicine 56 巻 ( 5 ) 頁： 481 - 485 2017年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Japanese Society of Internal Medicine

Objective The National Kidney Foundation (NKF) Kidney Disease Outcome Quality Initiative (KDOQI) guidelines have recommended the use of arteriovenous fistula (AVF) at the initiation of dialysis. However, there are significant differences in the dialysis environments of Japan and the United States, and there are few people who receive hemodialysis via a central venous catheter (CVC) in Japan. The aim of the present study was to examine the association between the type of vascular access at the initiation of dialysis and the incidence of mortality in Japan. Methods This study was a prospective, multicenter, cohort study. The data was collected by the Aichi Cohort study of Prognosis in Patients newly initiated into dialysis (AICOPP) in which 18 Japanese tertiary care centers participated. The present study enrolled 1,524 patients who were newly introduced to dialysis (the patients started maintenance dialysis between October 2011 and September 2013). After excluding 183 patients with missing data, 1,341 patients were enrolled. The Cox proportional hazards model was used to evaluate mortality based on the type of vascular access. The types of vascular access were divided into four categories: AVF, arteriovenous graft (AVG), CVC changed to AVF during the course (CAVF), CVC changed to AVG during the course (CAVG). Results A multivariate analysis revealed that AVG, CAVF and CAVG were associated with a higher risk of mortality in comparison to AVF [hazard ratio (HR), 1.60; p=0.048; HR, 2.26; p=0.003; and HR, 2.45; p=0.001, respectively]. Conclusion The research proved that the survival rate among patients in whom hemodialysis was initiated with AVF was significantly higher than that in patients in whom hemodialysis was initiated with AVG or CVC.

DOI： 10.2169/internalmedicine.56.7563

Web of Science

PubMed

CiNii Research

Single-dose Rituximab Therapy for Refractory Idiopathic Membranous Nephropathy: A Single-center Experience 査読有り

Katsuno Takayuki, Ozaki Takenori, Kim Hangsoo, Kato Noritoshi, Suzuki Yasuhiro, Akiyama Shinichi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Ito Yasuhiko, Maruyama Shoichi

Intern Med 56 巻 ( 13 ) 頁： 1679 - 1686 2017年

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Japanese Society of Internal Medicine

To date, a recognized treatment for refractory membranous nephropathy (MN) has not been established. Recently, several reports have indicated the efficacy of rituximab as a novel treatment option. However, only a few published accounts exist of rituximab therapy for idiopathic MN (IMN) in the Asian population. We present the cases of three IMN patients who were treated with single-dose rituximab after they showed no response to conventional therapies, including corticosteroids, cyclosporine, cyclophosphamide, mizoribine, and mycophenolate mofetil. Although one case showed no response, a complete or incomplete remission was achieved in the other two cases. Rituximab may therefore be a beneficial treatment option for IMN.

DOI： 10.2169/internalmedicine.56.7908

Web of Science

PubMed

CiNii Research

Kidney biopsy guidebook 2020 in Japan 査読有り

Clin Exp Nephrol 25 巻 ( 4 ) 頁： 325 - 364 2021年4月

Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer. 査読有り

Inamori K, Togashi Y, Fukuoka S, Akagi K, Ogasawara K, Irie T, Motooka D, Kobayashi Y, Sugiyama D, Kojima M, Shiiya N, Nakamura S, Maruyama S, Suzuki Y, Ito M, Nishikawa H

JCI Insight 6 巻 ( 9 ) 頁： e137365 2021年3月

Vascular endothelial growth factor (VEGF)-A and VEGF-A(165)b are associated with time to remission of granulomatosis with polyangiitis in a nationwide Japanese prospective cohort study 査読有り

Kikuchi Ryosuke, Tsuboi Naotake, Sada Ken-Ei, Nakatochi Masahiro, Yokoe Yuki, Suzuki Atsuo, Maruyama Shoichi, Murohara Toyoaki, Matsushita Tadashi, Amano Koichi, Atsumi Tatsuya, Takasaki Yoshinari, Ito Satoshi, Hasegawa Hitoshi, Dobashi Hiroaki, Ito Takafumi, Makino Hirofumi, Matsuo Seiichi

Ann Clin Bioche 58 巻 ( 2 ) 頁： 86 - 94 2021年3月

Refractory Hypotension Caused by Selenium Deficiency in a Patient on Peritoneal Dialysis. 査読有り

Ryuge A, Kim H, Suzuki Y, Okazaki M, Kojima H, Saito S, Kato N, Ishimoto T, Kosugi T, Maruyama S, Mizuno M

Intern Med 60 巻 ( 15 ) 頁： 2461 - 2464 2021年2月

Glucocorticoid treatment is associated with ICU-acquired hypernatremia: a nested case-control study 査読有り

Imaizumi Takahiro, Nakatochi Masahiro, Fujita Yoshiro, Yamamoto Rie, Watanabe Kennshi, Maekawa Michitaka, Yamawaka Taishi, Katsuno Takayuki, Maruyama Shoichi

Clin Exp Nephrol 25 巻 ( 2 ) 頁： 131 - 139 2021年2月

Initial responsiveness to darbepoetin alfa and its contributing factors in non-dialysis chronic kidney disease patients in Japan 査読有り

Hayashi Terumasa, Kato Hideki, Tanabe Kenichiro, Nangaku Masaomi, Hirakata Hideki, Wada Takashi, Sato Hiroshi, Yamazaki Yasushi, Masaki Takao, Kagimura Tatsuo, Yamamoto Hiroyasu, Hase Hiroki, Kamouchi Masahiro, Imai Enyu, Mizuno Kyoichi, Iwasaki Manabu, Akizawa Tadao, Tsubakihara Yoshiharu, Maruyama Shoichi, Narita Ichiei

Clin Exp Nephrol 25 巻 ( 2 ) 頁： 110 - 119 2021年2月

Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease 査読有り

Ozeki Takaya, Maruyama Shoichi, Imasawa Toshiyuki, Kawaguchi Takehiko, Kitamura Hiroshi, Kadomura Moritoshi, Katafuchi Ritsuko, Oka Kazumasa, Yokoyama Hitoshi, Sugiyama Hitoshi, Sato Hiroshi

Sci Rep 11 巻 ( 1 ) 頁： 2602 2021年1月

Cardiovascular disease history and β-blocker prescription patterns among Japanese and American patients with CKD: a cross-sectional study of the CRIC and CKD-JAC studies. 査読有り

Imaizumi Takahiro, Hamano Takayuki, Fujii Naohiko, Huang Jing, Xie Dawei, Ricardo Ana C., He Jiang, Soliman Elsayed Z., Kusek John W., Nessel Lisa, Yang Wei, Maruyama Shoichi, Fukagawa Masafumi, Feldman Harold I.

Hypertens Res 44 巻 ( 6 ) 頁： 700 - 710 2021年1月

The ISN/RPS 2016 classification predicts renal prognosis in patients with first-onset class III/IV lupus nephritis 査読有り

Hachiya Asaka, Karasawa Munetoshi, Imaizumi Takahiro, Kato Noritoshi, Katsuno Takayuki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Maruyama Shoichi

Sci Rep 11 巻 ( 1 ) 頁： 1525 2021年1月

Nephrotic syndrome with focal segmental glomerular lesions unclassified by Columbia classification; Pathology and clinical implication 査読有り

Ozeki Takaya, Nagata Michio, Katsuno Takayuki, Inagaki Koji, Goto Kazunori, Kato Sawako, Yasuda Yoshinari, Tsuboi Naotake, Maruyama Shoichi

PLoS One 16 巻 ( 1 ) 頁： e0244677 2021年1月

Effects of LDL apheresis on proteinuria in patients with diabetes mellitus, severe proteinuria, and dyslipidemia 査読有り

Wada Takashi, Hara Akinori, Muso Eri, Maruyama Shoichi, Kato Sawako, Furuichi Kengo, Yoshimura Kenichi, Toyama Tadashi, Sakai Norihiko, Suzuki Hiroyuki, Tsukamoto Tatsuo, Miyazaki Mariko, Sato Eiichi, Abe Masanori, Shibagaki Yugo, Narita Ichiei, Goto Shin, Sakamaki Yuichi, Yokoyama Hitoshi, Mori Noriko, Yuzawa Yukio, Hasegawa Midori, Matsubara Takeshi, Wada Jun, Tanabe Katsuyuki, Masutani Kosuke, Abe Yasuhiro, Tsuruya Kazuhiko, Fujimoto Shouichi, Iwatsubo Shuji, Tsuda Akihiro, Suzuki Hitoshi, Kasuno Kenji, Terada Yoshio, Nakata Takeshi, Iino Noriaki, Sofue Tadashi, Miyata Hitomi, Nakano Toshiaki, Ohtake Takayasu, Kobayashi Shuzo

Clin Exp Nephrol 25 巻 ( 1 ) 頁： 1 - 8 2021年1月

Impact of the number of steroid pulses in tonsillectomy combined with steroid pulse therapy: a nationwide retrospective study in Japan 査読有り

Moriyama Takahito, Kataoka Hiroshi, Nitta Kosaku, Hirano Keita, Matsuzaki Keiichi, Yasuda Takashi, Yasuda Yoshinari, Koike Kentaro, Maruyama Shoichi, Yokoo Takashi, Matsuo Seiichi, Kawamura Tetsuya, Suzuki Yusuke

Clin Exp Nephrol 25 巻 ( 1 ) 頁： 19 - 27 2021年1月

Oral Antibiotics are Effective for Preventing Colonoscopy-associated Peritonitis as a Preemptive Therapy in Patients on Peritoneal Dialysis 査読有り

Suzuki Yasuhiro, Mizuno Masashi, Kojima Hiroshi, Sato Yuka, Kim Hangsoo, Kinashi Hiroshi, Katsuno Takayuki, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko

Intern Med 60 巻 ( 3 ) 頁： 353 - 356 2021年

Acquired Fanconi Syndrome in a Patient with Nontyphoidal Salmonella Bacteremia 査読有り

Ryuge Akihiro, Saito Shoji, Morioka Hiroshi, Hachiya Asaka, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi

Intern Med 60 巻 ( 5 ) 頁： 761 - 764 2021年

Validity of "One-size-fits-all" Approaches for the National Health Screening and Education Program: A Large-Scale Cohort Study of Corporate Insurance Beneficiaries. 査読有り

Kikuchi K, Imaizumi T, Ando M, Kato S, Kondo T, Honda H, Yoshida Y, Maruyama S

Intern Med 60 巻 ( 11 ) 頁： 1681 - 1689 2020年12月

A Prospective, Randomized Clinical Trial of Etelcalcetide in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism (the DUET Trial) 査読有り

Itano Yuya, Kato Sawako, Tsuboi Masato, Kasuga Hirotake, Tsuruta Yoshinari, Sato Fumihiko, Hishida Manabu, Ishimoto Takuji, Kosugi Tomoki, Ando Masahiko, Kuwatsuka Yachiyo, Maruyama Shoichi

Kidney Int Rep 5 巻 ( 12 ) 頁： 2168 - 2177 2020年12月

High urinary glucose is associated with improved renal prognosis in patients with diabetes mellitus 査読有り

Itano Yuya, Sobajima Hiroshi, Ohashi Norimi, Shibata Taiga, Fujiya Atsushi, Nagata Takanobu, Ando Masahiko, Imaizumi Takahiro, Kubo Yoko, Ozeki Takaya, Katsuno Takayuki, Kato Sawako, Yasuda Yoshinari, Maruyama Shoichi

J Diabetes Investig 12 巻 ( 6 ) 頁： 998 - 1006 2020年11月

Long-term changes in renal function after treatment initiation and the importance of early diagnosis in maintaining renal function among IgG4-related tubulointerstitial nephritis patients in Japan 査読有り

Arai Haruna, Ogata Soshiro, Ozeki Takaya, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Inaguma Daijo, Hasegawa Midori, Yuzawa Yukio, Hayashi Hiroki

Arthritis Res Ther 22 巻 ( 1 ) 頁： 261 2020年11月

C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury. 査読有り

Tanaka M, Saka-Tanaka M, Ochi K, Fujieda K, Sugiura Y, Miyamoto T, Kohda H, Ito A, Miyazawa T, Matsumoto A, Aoe S, Miyamoto Y, Tsuboi N, Maruyama S, Suematsu M, Yamasaki S, Ogawa Y, Suganami T

J Exp Med 217 巻 ( 11 ) 頁： e20192230 2020年11月

The revised version 2018 of the nationwide web-based registry system for kidney diseases in Japan: Japan Renal Biopsy Registry and Japan Kidney Disease Registry. 査読有り

Ozeki T, Maruyama S, Nagata M, Shimizu A, Sugiyama H, Sato H, Yokoyama H, Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology.

Clin Exp Nephrol 24 巻 ( 11 ) 頁： 1058 - 1068 2020年11月

Prognostic Impact of Parameters of Metabolic Acidosis in Critically Ill Children with Acute Kidney Injury: A Retrospective Observational Analysis Using the PIC Database 査読有り

Morooka Hikaru, Kasugai Daisuke, Tanaka Akihito, Ozaki Masayuki, Numaguchi Atsushi, Maruyama Shoichi

Diagnostics (Basel) 10 巻 ( 11 ) 頁： 937 2020年11月

Prevalences of hyperuricemia and electrolyte abnormalities in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB) 査読有り

Sofue Tadashi, Nakagawa Naoki, Kanda Eiichiro, Nagasu Hajime, Matsushita Kunihiro, Nangaku Masaomi, Maruyama Shoichi, Wada Takashi, Terada Yoshio, Yamagata Kunihiro, Narita Ichiei, Yanagita Motoko, Sugiyama Hitoshi, Shigematsu Takashi, Ito Takafumi, Tamura Kouichi, Isaka Yoshitaka, Okada Hirokazu, Tsuruya Kazuhiko, Yokoyama Hitoshi, Nakashima Naoki, Kataoka Hiromi, Ohe Kazuhiko, Okada Mihoko, Kashihara Naoki

PLoS One 15 巻 ( 10 ) 頁： e0240402 2020年10月

Better remission rates in elderly Japanese patients with primary membranous nephropathy in nationwide real-world practice: The Japan Nephrotic Syndrome Cohort Study (JNSCS). 査読有り

Yokoyama H, Yamamoto R, Imai E, Maruyama S, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Fukami K, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Terada Y, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Furuichi K, Fujimoto K, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y

Clin Exp Nephrol 24 巻 ( 10 ) 頁： 893 - 909 2020年10月

Temporal change in life and renal prognosis of rapidly progressive glomerulonephritis in Japan via nationwide questionnaire survey (vol 23, pg 573, 2019) 査読有り

Yamagata Kunihiro, Usui Joichi, Sugiyama Hitoshi, Maruyama Shoichi, Narita Ichiei

Clin Exp Nephrol 24 巻 ( 10 ) 頁： 976 - 977 2020年10月

Comprehensive Dipeptide Profiling and Quantitation by Capillary Electrophoresis and Liquid Chromatography Coupled with Tandem Mass Spectrometry 査読有り

Ozawa Hitoshi, Hirayama Akiyoshi, Ishikawa Takamasa, Kudo Ryuhei, Maruyama Midori, Shoji Futaba, Doke Tomohito, Ishimoto Takuji, Maruyama Shoichi, Soga Tomoyoshi, Tomita Masaru

Anal Chem 92 巻 ( 14 ) 頁： 9799 - 9806 2020年7月

Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB). 査読有り

Sofue T, Nakagawa N, Kanda E, Nagasu H, Matsushita K, Nangaku M, Maruyama S, Wada T, Terada Y, Yamagata K, Narita I, Yanagita M, Sugiyama H, Shigematsu T, Ito T, Tamura K, Isaka Y, Okada H, Tsuruya K, Yokoyama H, Nakashima N, Kataoka H, Ohe K, Okada M, Kashihara N

PLoS One 15 巻 ( 7 ) 頁： e0236132 2020年7月

Impact of old age on the association between in-center extended-hours hemodialysis and mortality in patients on incident hemodialysis 査読有り

Okazaki Masaki, Inaguma Daijo, Imaizumi Takahiro, Hishida Manabu, Kurasawa Shimon, Kubo Yoko, Kato Sawako, Yasuda Yoshinari, Katsuno Takayuki, Kaneda Fumika, Maruyama Shoichi

PLoS One 15 巻 ( 7 ) 頁： e0235900 2020年7月

Complement profile in microscopic polyangiitis and granulomatosis with polyangiitis: analysis using sera from a nationwide prospective cohort study 査読有り

Fukui S., Ichinose K., Sada K-E, Miyamoto J., Harigai M., Amano K., Atsumi T., Takasaki Y., Dobashi H., Arimura Y., Hasegawa H., Yuzawa Y., Yamagata K., Tsuboi N., Maruyama S., Matsuo S., Makino H., Maeda T., Kawakami A.

Scand J Rheumatol 49 巻 ( 4 ) 頁： 301 - 311 2020年7月

Incidence of remission and relapse of proteinuria, end-stage kidney disease, mortality, and major outcomes in primary nephrotic syndrome: the Japan Nephrotic Syndrome Cohort Study (JNSCS). 査読有り

Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Terada Y, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y

Clin Exp Nephrol 24 巻 ( 6 ) 頁： 526 - 540 2020年6月

Darbepoetin Alfa in Patients with Advanced CKD without Diabetes: Randomized, Controlled Trial. 査読有り

Hayashi T, Maruyama S, Nangaku M, Narita I, Hirakata H, Tanabe K, Morita S, Tsubakihara Y, Imai E, Akizawa T, PREDICT Investigators.

Clin J Am Soc Nephrol 15 巻 ( 5 ) 頁： 608 - 615 2020年5月

A nationwide survey on clinical practice patterns and bleeding complications of percutaneous native kidney biopsy in Japan. 査読有り

Kawaguchi T, Nagasawsa T, Tsuruya K, Miura K, Katsuno T, Morikawa T, Ishikawa E, Ogura M, Matsumura H, Kurayama R, Matsumoto S, Marui Y, Hara S, Maruyama S, Narita I, Okada H, Ubara Y, Committee of Practical Guide for Kidney Biopsy 2019.

Clin Exp Nephrol 24 巻 ( 5 ) 頁： 389 - 401 2020年5月

J-CKD-DB: a nationwide multicentre electronic health record-based chronic kidney disease database in Japan. 査読有り

Nakagawa N, Sofue T, Kanda E, Nagasu H, Matsushita K, Nangaku M, Maruyama S, Wada T, Terada Y, Yamagata K, Narita I, Yanagita M, Sugiyama H, Shigematsu T, Ito T, Tamura K, Isaka Y, Okada H, Tsuruya K, Yokoyama H, Nakashima N, Kataoka H, Ohe K, Okada M, Kashihara N

Sci Rep 10 巻 ( 1 ) 頁： 7351 2020年4月

Inter-leg systolic blood pressure difference predicts cardiovascular events and mortality in incident hemodialysis patients 査読有り

Kato Sawako, Lindholm Bengt, Qureshi Abdul Rashid, Mukai Hideyuki, Yuzawa Yukio, Maruyama Shoichi

Int J Artif Organs 43 巻 ( 4 ) 頁： 217 - 224 2020年4月

Survival Benefit of Maintained or Increased Body Mass Index in Patients Undergoing Extended-Hours Hemodialysis Without Dietary Restrictions 査読有り

Hishida Manabu, Imaizumi Takahiro, Nishiyama Toshiro, Okazaki Masaki, Kaihan Ahmad Baseer, Kato Sawako, Kubo Yoko, Ando Masahiko, Kaneda Hiroshi, Maruyama Shoichi

J Ren Nutr 30 巻 ( 2 ) 頁： 154 - 162 2020年3月

Pharmacological monitoring of antiepileptic drugs in epilepsy patients on haemodialysis 査読有り

Araki Kunihiko, Nakamura Tomohiko, Takeuchi Yuko, Morozumi Saori, Horie Katsunori, Kobayashi Yasushi, Kawakami Osamu, Sobue Fumio, Ueda Takuya, Hamada Kensuke, Ando Tetsuo, Inoue Yushi, Yasui Keizo, Morozumi Kunio, Maruyama Shoichi, Katsuno Masahisa

Epileptic Disord 22 巻 ( 1 ) 頁： 90 - 102 2020年2月

Effectiveness of Lifestyle Intervention Using the Internet of Things System for Individuals with Early Type 2 Diabetes Mellitus 査読有り

Kato Sawako, Ando Masahiko, Honda Hiroyuki, Yoshida Yasuko, Imaizumi Takahiro, Yamamoto Naoki, Maruyama Shoichi

Intern Med 59 巻 ( 1 ) 頁： 45 - 53 2020年

Ectopic Relapse of Anti-neutrophil Cytoplasmic Antibody-associated Pituitary Vasculitis with No Elevation of Anti-neutrophil Cytoplasmic Antibodies after Renal Remission. 査読有り

Muto R, Inagaki K, Sato N, Sameshima T, Nagakura Y, Baba S, Kato N, Maruyama S, Akahori T

Intern Med 59 巻 ( 24 ) 頁： 3187 - 3193 2020年

Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia 査読有り

Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

Intern Med 59 巻 ( 5 ) 頁： 683 - 687 2020年

Peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study 査読有り

Morooka Hikaru, Tanaka Akihito, Inaguma Daijo, Maruyama Shoichi

BMJ Open 10 巻 ( 12 ) 頁： e042315 2020年

Lower levels of proteinuria are associated with elevated mortality in incident dialysis patients 査読有り

Hishida Manabu, Shafi Tariq, Appel Lawrence J., Maruyama Shoichi, Inaguma Daijo, Matsushita Kunihiro

PLoS One 14 巻 ( 12 ) 頁： e0226866 2019年12月

Excessive salt intake increases peritoneal solute transport rate via local tonicity-responsive enhancer binding protein in subtotal nephrectomized mice 査読有り

Sun Ting, Sakata Fumiko, Ishii Takako, Tawada Mitsuhiro, Suzuki Yasuhiro, Kinashi Hiroshi, Katsuno Takayuki, Takei Yoshifumi, Maruyama Shoichi, Mizuno Masashi, Ito Yasuhiko

Nephrol Dial Transplant 34 巻 ( 12 ) 頁： 2031 - 2042 2019年12月

Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure 査読有り

Sato Yuka, Roncal-Jimenez Carlos A., Andres-Hernando Ana, Jensen Thomas, Tolan Dean R., Sanchez-Lozada Laura G., Newman Lee S., Butler-Dawson Jaime, Sorensen Cecilia, Glaser Jason, Miyazaki Makoto, Diaz Henry F., Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Garcia Gabriela E., Lanaspa Miguel A., Johnson Richard J.

American journal of physiology. Renal physiology 317 巻 ( 5 ) 頁： F1111 - F1121 2019年11月

Variations in actual practice patterns and their deviations from the clinical practice guidelines for nephrotic syndrome in Japan: certified nephrologists' questionnaire survey 査読有り

Niihata Kakuya, Nishiwaki Hiroki, Kurita Noriaki, Okada Hirokazu, Maruyama Shoichi, Narita Ichiei, Shibagaki Yugo, Nakaya Izaya

Clin Exp Nephrol 23 巻 ( 11 ) 頁： 1288 - 1297 2019年11月

Circulating levels of CD34(+) cells predict longterm cardiovascular outcomes in patients on maintenance hemodialysis 査読有り

Kaihan Ahmad Baseer, Hishida Manabu, Imaizumi Takahiro, Okazaki Masaki, Kaihan Ahmad Naseer, Katsuno Takayuki, Taguchi Akihiko, Yasuda Yoshinari, Tsuboi Naotake, Kosugi Tomoki, Maruyama Shoichi

PLoS One 14 巻 ( 10 ) 頁： e0223390 2019年10月

Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase 査読有り

Hayasaki Takahiro, Ishimoto Takuji, Doke Tomohito, Hirayama Akiyoshi, Soga Tomoyoshi, Furuhashi Kazuhiro, Kato Noritoshi, Kosugi Tomoki, Tsuboi Naotake, Lanaspa Miguel A., Johnson Richard J., Maruyama Shoichi, Kadomatsu Kenji

J Nutr Biochem 71 巻頁： 54 - 62 2019年9月

Connective tissue growth factor is correlated with peritoneal lymphangiogenesis 査読有り

Kinashi Hiroshi, Toda Naohiro, Sun Ting, Nguyen Tri Q., Suzuki Yasuhiro, Katsuno Takayuki, Yokoi Hideki, Aten Jan, Mizuno Masashi, Maruyama Shoichi, Yanagita Motoko, Goldschmeding Roel, Ito Yasuhiko

Sci Rep 9 巻 ( 1 ) 頁： 12175 2019年8月

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction 査読有り

Hara Akitoshi, Kobayashi Hiroki, Asai Naoya, Saito Shigeyoshi, Higuchi Takahiro, Kato Katsuhiro, Okumura Takahiro, Bando Yasuko K., Takefuji Mikito, Mizutani Yasuyuki, Miyai Yuki, Saito Shoji, Maruyama Shoichi, Maeda Keiko, Ouchi Noriyuki, Nagasaka Arata, Miyata Takaki, Mii Shinji, Kioka Noriyuki, Worthley Daniel L., Murohara Toyoaki, Takahashi Masahide, Enomoto Atsushi

Circ Res 125 巻 ( 4 ) 頁： 414 - 430 2019年8月

miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury 査読有り

Funahashi Yoshio, Kato Noritoshi, Masuda Tomohiro, Nishio Fumitoshi, Kitai Hiroki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Matsuda Naoyuki, Maruyama Shoichi, Kadomatsu Kenji

Lab Invest 99 巻 ( 8 ) 頁： 1130 - 1142 2019年8月

The effect of maintaining high hemoglobin levels on long-term kidney function in kidney transplant recipients: a randomized controlled trial 査読有り

Tsujita Makoto, Kosugi Tomoki, Goto Norihiko, Futamura Kenta, Nishihira Morikuni, Okada Manabu, Hiramitsu Takahisa, Narumi Shunji, Uchida Kazuharu, Takeda Asami, Morozumi Kunio, Maruyama Shoichi, Watarai Yoshihiko

Nephrol Dial Transplant 34 巻 ( 8 ) 頁： 1409 - 1416 2019年8月

CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling 査読有り

Yoshioka Tomoki, Kosugi Tomoki, Masuda Tomohiro, Watanabe Tomoharu, Ryuge Akihiro, Nagaya Hiroshi, Maeda Kayaho, Sato Yuka, Katsuno Takayuki, Kato Noritoshi, Ishimoto Takuji, Yuzawa Yukio, Maruyama Shoichi, Kadomatsu Kenji

Am J Pathol 189 巻 ( 7 ) 頁： 1338 - 1350 2019年7月

Association Between Tonsillectomy and Outcomes in Patients With Immunoglobulin A Nephropathy 査読有り

Hirano Keita, Matsuzaki Keiichi, Yasuda Takashi, Nishikawa Masako, Yasuda Yoshinari, Koike Kentaro, Maruyama Shoichi, Yokoo Takashi, Matsuo Seiichi, Kawamura Tetsuya, Suzuki Yusuke

JAMA Netw Open 2 巻 ( 5 ) 頁： e194772 2019年5月

Effects of long-term treatment with low-GDP, pH-neutral solutions on peritoneal membranes in peritoneal dialysis patients 査読有り

Tawada Mitsuhiro, Hamada Chieko, Suzuki Yasuhiro, Sakata Fumiko, Sun Ting, Kinashi Hiroshi, Katsuno Takayuki, Takei Yoshifumi, Maruyama Shoichi, Honda Kazuho, Mizuno Masashi, Ito Yasuhiko

Clin Exp Nephrol 23 巻 ( 5 ) 頁： 689 - 699 2019年5月

Temporal change in life and renal prognosis of rapidly progressive glomerulonephritis in Japan via nationwide questionnaire survey. 査読有り

Yamagata K, Usui J, Sugiyama H, Maruyama S, Narita I

Clin Exp Nephrol 23 巻 ( 4 ) 頁： 573 - 575 2019年4月

A grading system that predicts the risk of dialysis induction in IgA nephropathy patients based on the combination of the clinical and histological severity. 査読有り

Okonogi H, Kawamura T, Joh K, Koike K, Miyazaki Y, Ogura M, Tsuboi N, Hirano K, Matsushima M, Yokoo T, Horikoshi S, Suzuki Y, Yasuda T, Shirai S, Shibata T, Hattori M, Akioka Y, Katafuchi R, Hashiguchi A, Hisano S, Shimizu A, Kimura K, Maruyama S, Matsuo S, Tomino Y, Special IgA Nephropathy Study Group.

Clin Exp Nephrol 23 巻 ( 1 ) 頁： 16 - 25 2019年1月

Increase of Eosinophil in Dialysate During Induction of Peritoneal Dialysis. 査読有り

Shigemoto Emi, Mizuno Masashi, Suzuki Yasuhiro, Kobayashi Kazuma, Sakata Fumiko, Kariya Tetsuyoshi, Katsuno Takayuki, Maruyama Shoichi, Ito Yasuhiko

Perit Dial Int 39 巻 ( 1 ) 頁： 90 - 92 2019年

Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease 査読有り

Ozeki Takaya, Katsuno Takayuki, Hayashi Hiroki, Kato Sawako, Yasuda Yoshinari, Ando Masahiko, Tsuboi Naotake, Hagiwara Daisuke, Arima Hiroshi, Maruyama Shoichi

Am J Nephrol 49 巻 ( 1 ) 頁： 54 - 63 2019年

Regional variations in immunosuppressive therapy in patients with primary nephrotic syndrome: the Japan nephrotic syndrome cohort study. 査読有り

Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Fukami K, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Yoshio T, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y

Clin Exp Nephrol 22 巻 ( 6 ) 頁： 1266 - 1280 2018年12月

A Refractory Case of Secondary Membranous Nephropathy Concurrent with IgG4-related Tubulointerstitial Nephritis. 査読有り

Arai H, Toda N, Kamimatsuse R, Nishioka K, Endo S, Akiyama S, Maruyama S, Matsubara T, Yokoi H, Yanagita M

Internal medicine (Tokyo, Japan) 57 巻 ( 19 ) 頁： 2873 - 2877 2018年10月

The association between intensive care unit-acquired hypernatraemia and mortality in critically ill patients with cerebrovascular diseases: a single-centre cohort study in Japan. 査読有り

Imaizumi T, Nakatochi M, Fujita Y, Nomura R, Watanabe K, Maekawa M, Yamakawa T, Katsuno T, Maruyama S

BMJ open 7 巻 ( 8 ) 頁： e016248 2017年8月

Calcineurin Inhibitor-Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report 査読有り

Ishida S., Kato M., Fujita T., Funahashi Y., Sassa N., Matsukawa Y., Yoshino Y., Yamamoto T., Katsuno T., Maruyama S., Gotoh M.

Transplant Proc 49 巻 ( 1 ) 頁： 163 - 166 2017年

Clinical guides for atypical hemolytic uremic syndrome in Japan. 査読有り

Kato H, Nangaku M, Hataya H, Sawai T, Ashida A, Fujimaru R, Hidaka Y, Kaname S, Maruyama S, Yasuda T, Yoshida Y, Ito S, Hattori M, Miyakawa Y, Fujimura Y, Okada H, Kagami S; Joint Committee for the Revision of Clinical Guides of Atypical Hemolytic Uremic Syndrome in Japan.

Clin Exp Nephrol 20 巻 ( 4 ) 頁： 536 - 543 2016年9月

Antineutrophil Cytoplasmic Antibody-associated Vasculitis Superimposed on Infection-related Glomerulonephritis Secondary to Pulmonary Mycobacterium avium Complex Infection. 査読有り

Asano S, Mizuno S, Okachi S, Aso H, Wakahara K, Hashimoto N, Ito S, Kozaki Y, Katsuno T, Maruyama S, Hasegawa Y.

Intern Med 55 巻 ( 17 ) 頁： 2439 - 2445 2016年8月

Clinical guides for atypical hemolytic uremic syndrome in Japan. 査読有り

Pediatr Int 58 巻 ( 7 ) 頁： 549 - 555 2016年8月

Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report. 査読有り

Kubota K, Hoshino J, Ueno T, Mise K, Hazue R, Sekine A, Yabuuchi J, Yamanouchi M, Suwabe T, Kikuchi K, Sumida K, Hayami N, Sawa N, Takaichi K, Fujii T, Ohashi K, Akiyama S, Maruyama S, Ubara Y.

Case Rep Nephrol Dial 6 巻 ( 2 ) 頁： 76 - 82 2016年7月

Urinary soluble CD163 level reflects glomerular inflammation in human lupus nephritis. 査読有り

Endo N, Tsuboi N, Furuhashi K, Shi Y, Du Q, Abe T, Hori M, Imaizumi T, Kim H, Katsuno T, Ozaki T, Kosugi T, Matsuo S, Maruyama S.

Nephrol Dial Transplant 31 巻 ( 12 ) 頁： 2023 - 2033 2016年5月

Randomized control trial for the assessment of the anti-albuminuric effects of topiroxostat in hyperuricemic patients with diabetic nephropathy (the ETUDE study). 査読有り

Kato S, Ando M, Mizukoshi T, Nagata T, Katsuno T, Kosugi T, Tsuboi N, Maruyama S.

Nagoya J Med Sci 78 巻 ( 2 ) 頁： 135 - 142 2016年5月

Association between 24h Urinary Sodium and Potassium Excretion and Estimated Glomerular Filtration Rate (eGFR) Decline or Death in Patients with Diabetes Mellitus and eGFR More than 30 ml/min/1.73m2. 査読有り

Nagata T, Sobajima H, Ohashi N, Hirakawa A, Katsuno T, Yasuda Y, Matsuo S, Tsuboi N, Maruyama S.

PLoS One 11 巻 ( 5 ) 頁： e0152306 2016年5月

Ischemic Acute Tubular Necrosis due to Diltiazem Overdose. 査読有り

Ryuge A, Shimizu H, Ohyama Y, Yamaguchi M, Nomura A, Maruyama S, Kitamura H, Fujita Y.

Intern Med 55 巻 ( 9 ) 頁： 1149 - 1151 2016年5月

High Ferritin Level and Malnutrition Predict High Risk of Infection-Related Hospitalization in Incident Dialysis Patients: A Japanese Prospective Cohort Study. 査読有り

Kato S, Lindholm B, Yuzawa Y, Tsuruta Y, Nakauchi K, Yasuda K, Sugiura S, Morozumi K, Tsuboi N, Maruyama S.

Blood Purif 42 巻 ( 1 ) 頁： 56 - 63 2016年4月

The effectiveness and safety of modest exercise in Japanese patients with chronickidney disease: a single-armed interventional study. 査読有り

Masami Hamada, Yoshinari Yasuda, Sawako Kato, Hiroki Arafuka, Motomitsu Goto, Mutsuharu Hayashi, Etsuko Kajita, Shoichi Maruyama

Clin Exp Nephrol 20 巻 ( 2 ) 頁： 204 - 211 2016年4月

Identification of C1q as a Binding Protein for Advanced Glycation End Products. 査読有り

Chikazawa M, Shibata T, Hatasa Y, Hirose S, Otaki N, Nakashima F, Ito M, Machida S, Maruyama S, Uchida K.

Biochemistry 55 巻 ( 3 ) 頁： 435 - 446 2016年1月

Urinary Podocalyxin as a Biomarker to Diagnose Membranous Nephropathy. 査読有り

Imaizumi T, Nakatochi M, Akiyama S, Yamaguchi M, Kurosawa H, Hirayama Y, Katsuno T, Tsuboi N, Hara M, Maruyama S.

PLoS One 11 巻 ( 9 ) 頁： e0163507 2016年

Vascular Endothelial Cell Injury Is an Important Factor in the Development of Encapsulating Peritoneal Sclerosis in Long-Term Peritoneal Dialysis Patients. 査読有り

Tawada M, Ito Y, Hamada C, Honda K, Mizuno M, Suzuki Y, Sakata F, Terabayashi T, Matsukawa Y, Maruyama S, Imai E, Matsuo S, Takei Y.

PLoS One 11 巻 ( 4 ) 頁： e0154644 2016年

In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy. 査読有り

Serino G, Pesce F, Sallustio F, De Palma G, Cox SN, Curci C, Zaza G, Lai KN, Leung JC, Tang SC, Papagianni A, Stangou M, Goumenos D, Gerolymos M, Takahashi K, Yuzawa Y, Maruyama S, Imai E, Schena FP.

Kidney Int 89 巻 ( 3 ) 頁： 683 - 692 2015年11月

Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease. 査読有り

Kato S, Shiels PG, McGuinness D, Lindholm B, Stenvinkel P, Nordfors L, Qureshi AR, Yuzawa Y, Matsuo S, Maruyama S.

Blood Purif 41 巻 ( 1-3 ) 頁： 25 - 33 2015年10月

Neutrophil/lymphocyte ratio as a predictor of cardiovascular events in incident dialysis patients: a Japanese prospective cohort study. 査読有り

Abe T1, Kato S, Tsuruta Y, Sugiura S, Katsuno T, Kosugi T, Tsuboi N, Matsuo S, Maruyama S.

Clin Exp Nephrol 19 巻 ( 4 ) 頁： 718 - 724 2015年10月

Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury. 査読有り

Hattori Y, Kim H, Tsuboi N, Yamamoto A, Akiyama S, Shi Y, Katsuno T, Kosugi T, Ueda M, Matsuo S, Maruyama S.

PLoS One 10 巻 ( 10 ) 頁： e0140121 2015年10月

Increase of Antimyeloperoxidase Antineutrophil Cytoplasmic Antibody (ANCA) in Patients with Renal ANCA-associated Vasculitis: Association with Risk to Relapse. 査読有り

Yamaguchi M, Ando M, Kato S, Katsuno T, Kato N, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S.

J Rheumatol 42 巻 ( 10 ) 頁： 1853 - 1860 2015年10月

Impact of abdominal aortic calcification on long-term cardiovascular outcomes in patients with chronic kidney disease. 査読有り

Tatami Y, Yasuda Y, Suzuki S, Ishii H, Sawai A, Shibata Y, Ota T, Shibata K, Niwa M, Morimoto R, Hayashi M, Kato S, Maruyama S, Murohara T.

Atherosclerosis 243 巻 ( 2 ) 頁： 349 - 355 2015年10月

Impact of non-invasive cardiovascular screening programs as a predictor of cardiovascular events among asymptomatic chronic kidney disease patients. 査読有り

Sawai A, Yasuda Y, Suzuki S, Ishii H, Goto M, Kato S, Hayashi M, Maruyama S, Murohara T, Oiso Y, Matsuo S.

Clin Exp Nephrol 20 巻 ( 3 ) 頁： 416 - 424 2015年9月

Association of Estimated Glomerular Filtration Rate and Proteinuria With Lipid-Rich Plaque in Coronary Artery Disease. 査読有り

Shimbo Y, Suzuki S, Ishii H, Shibata Y, Tatami Y, Harata S, Osugi N, Ota T, Tanaka A, Shibata K, Mizukoshi T, Yasuda Y, Maruyama S, Murohara T.

Circ J 79 巻 ( 10 ) 頁： 2263 - 2270 2015年9月

Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy. 査読有り

Akiyama S, Akiyama M, Imai E, Ozaki T, Matsuo S, Maruyama S.

Clin Exp Nephrol 19 巻 ( 4 ) 頁： 653 - 660 2015年8月

Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids. 査読有り

Sato Y, Sato W, Maruyama S, Wilcox CS, Falck JR, Masuda T, Kosugi T, Kojima H, Maeda K, Furuhashi K, Ando M, Imai E, Matsuo S, Kadomatsu K.

J Am Soc Nephrol 26 巻 ( 8 ) 頁： 1806 - 1815 2015年8月

CD147 (EMMPRIN/Basigin) in kidney diseases: from an inflammation and immune system viewpoint. 査読有り

Kosugi T1, Maeda K1, Sato W1, Maruyama S1, Kadomatsu K2.

Nephrol Dial Transplant 30 巻 ( 7 ) 頁： 1097 - 1103 2015年7月

Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy. 査読有り

Sei Y, Mizuno M, Suzuki Y, Imai M, Higashide K, Harris CL, Sakata F, Iguchi D, Fujiwara M, Kodera Y, Maruyama S, Matsuo S, Ito Y.

Mol Immunol 65 巻 ( 2 ) 頁： 302 - 309 2015年6月

Relationship between abdominal aortic and coronary artery calcification as detected by computed tomography in chronic kidney disease patients. 査読有り

Takayama Y, Yasuda Y, Suzuki S, Shibata Y, Tatami Y, Shibata K, Niwa M, Sawai A, Morimoto R, Kato S, Ishii H, Maruyama S, Murohara T.

Heart Vessels 31 巻 ( 7 ) 頁： 1030 - 1037 2015年6月

Longitudinal Study of the Decline in Renal Function in Healthy Subjects. 査読有り

Baba M, Shimbo T, Horio M, Ando M, Yasuda Y, Komatsu Y, Masuda K, Matsuo S, Maruyama S.

PLoS One 10 巻 ( 6 ) 頁： e0129036 2015年6月

Clinical impact of kidney function on presepsin levels. 査読有り

Nagata T, Yasuda Y, Ando M, Abe T, Katsuno T, Kato S, Tsuboi N, Matsuo S, Maruyama S.

PLoS One 10 巻 ( 6 ) 頁： e0129159 2015年6月

Rationale and study design of a randomized controlled trial to assess the effects of maintaining hemoglobin levels using darbepoetin alfa on prevention of development of end-stage kidney disease in non-diabetic CKD patients (PREDICT Trial). 査読有り

Imai E, Maruyama S, Nangaku M, Hirakata H, Hayashi T, Narita I, Kono H, Nakatani E, Morita S, Tsubakihara Y, Akizawa T.

Clin Exp Nephrol 20 巻 ( 1 ) 頁： 71 - 76 2015年6月

CD147/Basigin limits lupus nephritis and TH 17 cell differentiation by inhibiting the IL-6/STAT3 pathway. 査読有り

Maeda K, Kosugi T, Sato W, Kojima H, Sato Y, Kamimura D, Kato N, Tsuboi N, Yuzawa Y, Matsuo S, Murakami M, Maruyama S, Kadomatsu K.

Arthritis Rheum 67 巻 ( 8 ) 頁： 2185 - 2195 2015年5月

Functional Difference Between Membrane-Bound and Soluble Human Thrombomodulin. 査読有り

Miwa Y, Yazaki S, Iwamoto M, Suzuki S, Iwasaki K, Haneda M, Yamamoto K, Maruyama S, Onishi A, Kobayashi T.

Transplantation 99 巻 ( 4 ) 頁： 702 - 709 2015年4月

Vascular endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury. 査読有り

Terabayashi T, Ito Y, Mizuno M, Suzuki Y, Kinashi H, Sakata F, Tomita T, Iguchi D, Tawada M, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.

Lab Invest 95 巻 ( 9 ) 頁： 1029 - 1043 2015年4月

Renal function evaluation in patients with cancer who were scheduled to receive carboplatin or S-1. 査読有り

Shibata K, Yasuda Y, Kobayashi R, Ando Y, Shimokata T, Kamiya H, Hayashi M, Maruyama S, Matsuo S, Nakao M, Tsuchiya T, Teramachi H.

Clin Exp Nephrol 19 巻 ( 6 ) 頁： 1107 - 1113 2015年4月

The efficacy of tolvaptan as a diuretic for chronic kidney disease patients. 査読有り

Tanaka A, Katsuno T, Ozaki T, Sakata F, Kato N, Suzuki Y, Kosugi T, Kato S, Tsuboi N, Sato W, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S.

Acta Cardiol 70 巻 ( 2 ) 頁： 217 - 223 2015年4月

Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial. 査読有り

Kato S, Maruyama S, Makino H, Wada J, Ogawa D, Uzu T, Araki H, Koya D, Kanasaki K, Oiso Y, Goto M, Nishiyama A, Kobori H, Imai E, Ando M, Matsuo S.

Clin Exp Nephrol 19 巻 ( 6 ) 頁： 1098 - 1106 2015年3月

Identification of an Interaction between VWF rs7965413 and Platelet Count as a Novel Risk Marker for Metabolic Syndrome: An Extensive Search of Candidate Polymorphisms in a Case-Control Study. 査読有り

Nakatochi M, Ushida Y, Yasuda Y, Yoshida Y, Kawai S, Kato R, Nakashima T, Iwata M, Kuwatsuka Y, Ando M, Hamajima N, Kondo T, Oda H, Hayashi M, Kato S, Yamaguchi M, Maruyama S, Matsuo S, Honda H.

PLoS One 10 巻 ( 2 ) 頁： e0117591 2015年

A ray of light in the dark: alternative approaches to the assessment and treatment of ischemic nephropathy. 査読有り

Tsuboi N, Maruyama S, Matsuo S, Imai E.

Nephrol Dial Transplant 29 巻 ( 2 ) 頁： 228 - 231 2014年

Pristane-induced granulocyte recruitment promotes phenotypic conversion of macrophages and protects against diffuse pulmonary hemorrhage in Mac-1 deficiency. 査読有り

Shi Y1, Tsuboi N2, Furuhashi K3, Du Q1, Horinouchi A1, Maeda K1, Kosugi T1, Matsuo S1, Maruyama S1.

J Immunol 193 巻 ( 10 ) 頁： 5129 - 5139 2014年

CD147/basigin reflects renal dysfunction in patients with acute kidney injury. 査読有り

Nagaya H1, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.

Clin Exp Nephrol 18 巻 ( 5 ) 頁： 746 - 754 2014年

Smoking is a risk factor for the progression of idiopathic membranous nephropathy. 査読有り

Yamaguchi M1, Ando M2, Yamamoto R3, Akiyama S1, Kato S1, Katsuno T1, Kosugi T1, Sato W1, Tsuboi N1, Yasuda Y1, Mizuno M1, Ito Y1, Matsuo S1, Maruyama S1.

PLoS One 9 巻 ( 6 ) 頁： e100835 2014年

Plasma CD147 reflects histological features in patients with lupus nephritis. 査読有り

Maeda-Hori M1, Kosugi T, Kojima H, Sato W, Inaba S, Maeda K, Nagaya H, Sato Y, Ishimoto T, Ozaki T, Tsuboi N, Muro Y, Yuzawa Y, Imai E, Johnson RJ, Matsuo S, Kadomatsu K, Maruyama S.

Lupus 23 巻 ( 4 ) 頁： 342 - 352 2014年

A multicenter cross-sectional study of circulating soluble urokinase receptor in Japanese patients with glomerular disease. 査読有り

Wada T, Nangaku M, Maruyama S, Imai E, Shoji K, Kato S, Endo T, Muso E, Kamata K, Yokoyama H, Fujimoto K, Obata Y, Nishino T, Kato H, Uchida S, Sasatomi Y, Saito T, Matsuo S.

Kidney Int 85 巻 ( 3 ) 頁： 641 - 648 2014年

Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation. 査読有り

Kim H, Mizuno M, Furuhashi K, Katsuno T, Ozaki T, Yasuda K, Tsuboi N, Sato W, Suzuki Y, Matsuo S, Ito Y, Maruyama S.

Cytotherapy 16 巻 ( 3 ) 頁： 357 - 368 2014年

Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis. 査読有り

Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K.

Am J Pathol 182 巻 ( 2 ) 頁： 410 - 419 2013年

Perforative peritonitis caused by appendicitis in a patient on peritoneal dialysis. 査読有り

Mizuno M, Suzuki Y, Nonaka K, Sei Y, Maruyama S, Matsuo S, Ito Y.

Intern Med 52 巻 ( 11 ) 頁： 1177 - 1181 2013年

Anti-C5a complementary peptide ameliorates acute peritoneal injuries induced by neutralization of Crry and CD59. 査読有り

Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y.

Am J Physiol Renal Physiol 305 巻 ( 11 ) 頁： F1603 - 1616 2013年

Serum-Starved Adipose-Derived Stromal Cells Ameliorate Crescentic GN by Promoting Immunoregulatory Macrophages. 査読有り

Furuhashi K, Tsuboi N, Shimizu A, Katsuno T, Kim H, Saka Y, Ozaki T, Sado Y, Imai E, Matsuo S, Maruyama S.

J Am Soc Nephrol 24 巻 ( 4 ) 頁： 587 - 603 2013年

Multi-specificity of IgM antibodies raised against advanced glycation end products: Involvement of electronegative potential of antigens. 査読有り

Chikazawa M, Otaki N, Shibata T, Miyashita H, Kawai Y, Maruyama S, Toyokuni S, Kitaura Y, Matsuda T, Uchida K.

J Biol Chem 288 巻 ( 19 ) 頁： 13204 - 13214 2013年

Association of cardiac valvular calcifications and C-reactive protein with cardiovascular mortality in incident hemodialysis patients: a Japanese cohort study. 査読有り

Takahashi H, Ishii H, Aoyama T, Kamoi D, Kasuga H, Ito Y, Yasuda K, Tanaka M, Yoshikawa D, Maruyama S, Matsuo S, Murohara T, Yuzawa Y.

Am J Kidney Dis 61 巻 ( 2 ) 頁： 254 - 261 2013年

TGF-beta1 Promotes Lymphangiogenesis during Peritoneal Fibrosis. 査読有り

Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.

J Am Soc Nephrol 24 巻 ( 10 ) 頁： 1627 - 1642 2013年

Aliskiren-induced chyloperitoneum in a patient on peritoneal dialysis. 査読有り

Saka Y, Tachi H, Sakurai H, Tawada M, Sawai A, Shimamura Y, Mizuno M, Maruyama S, Matsuo S, Ito Y.

Perit Dial Int 32 巻 ( 1 ) 頁： 111 - 113 2012年

Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis. 査読有り

Nishiwaki S, Nakayama T, Saito S, Mizuno H, Ozaki T, Takahashi Y, Maruyama S, Nishida T, Murata M, Kojima S, Naoe T.

Int J Hematol 96 巻 ( 3 ) 頁： 295 - 300 2012年

Impact of diabetes and glycaemic control on peripheral artery disease in Japanese patients with end-stage renal disease: long-term follow-up study from the beginning of haemodialysis. 査読有り

Ishii H, Kumada Y, Takahashi H, Toriyama T, Aoyama T, Tanaka M, Yoshikawa D, Hayashi M, Kasuga H, Yasuda Y, Maruyama S, Matsubara T, Matsuo S, Murohara T.

Diabetologia 55 巻 ( 5 ) 頁： 1304 - 1309 2012年

Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. 査読有り

Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ.

P Natl Acad Sci USA 109 巻 ( 11 ) 頁： 4320 - 4325 2012年

DNA hypermethylation and inflammatory markers in incident Japanese dialysis patients. 査読有り

Kato S, Lindholm B, Stenvinkel P, Ekström TJ, Luttropp K, Yuzawa Y, Yasuda Y, Tsuruta Y, Maruyama S.

Nephron Extra 2 巻 ( 1 ) 頁： 159 - 168 2012年

Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats. 査読有り

Katsuno T, Ozaki T, Saka Y, Furuhashi K, Kim H, Yasuda K, Yamamoto T, Sato W, Tsuboi N, Mizuno M, Ito Y, Imai E, Matsuo S, Maruyama S.

Cell Transplant 22 巻 ( 2 ) 頁： 287 - 289 2012年

Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy. 査読有り

Hirayama A, Nakashima E, Sugimoto M, Akiyama SI, Sato W, Maruyama S, Matsuo S, Tomita M, Yuzawa Y, Soga T.

Anal Bioanal Chem 404 巻 ( 10 ) 頁： 3101 - 3109 2012年

Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis. 査読有り

Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.

Nephrol Dial Transplant 27 巻 ( 6 ) 頁： 2511 - 2516 2012年

Distribution of hydrogen sulfide (H(2)S)-producing enzymes and the roles of the H(2)S donor sodium hydrosulfide in diabetic nephropathy. 査読有り

Yamamoto J, Sato W, Kosugi T, Yamamoto T, Kimura T, Taniguchi S, Kojima H, Maruyama S, Imai E, Matsuo S, Yuzawa Y, Niki I.

Clin Exp Nephrol 17 巻 ( 1 ) 頁： 32 - 40 2012年

Combined Values of Serum Albumin, C-Reactive Protein and Body Mass Index at Dialysis Initiation Accurately Predicts Long-Term Mortality. 査読有り

Takahashi R, Ito Y, Takahashi H, Ishii H, Kasuga H, Mizuno M, Suzuki Y, Yuzawa Y, Maruyama S, Murohara T, Imai E, Matsuo S.

Am J Nephrol 36 巻 ( 2 ) 頁： 136 - 143 2012年

Autologous cell therapy for cisplatin-induced acute kidney injury by using non-expanded adipose tissue-derived cells. 査読有り

Yasuda K, Ozaki T, Saka Y, Yamamoto T, Gotoh M, Ito Y, Yuzawa Y, Matsuo S, Maruyama S.

Cytotherapy 14 巻 ( 9 ) 頁： 1089 - 1100 2012年

Complete remission within 2 years predicts a good prognosis after methylprednisolone pulse therapy in patients with IgA nephropathy. 査読有り

Tatematsu M, Yasuda Y, Morita Y, Sakamoto I, Kurata K, Naruse T, Yamamoto R, Tsuboi N, Sato W, Imai E, Matsuo S, Maruyama S.

Clin Exp Nephrol 16 巻 ( 6 ) 頁： 883 - 891 2012年

microRNA-Induced IgA Nephropathy. 査読有り

Imai E, Maruyama S.

J Am Soc Nephrol 23 巻 ( 5 ) 頁： 765 - 766 2012年

A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin. 査読有り

Ito I, Ito Y, Mizuno M, Suzuki Y, Yasuda K, Ozaki T, Kosugi T, Yasuda Y, Sato W, Tsuboi N, Maruyama S, Imai E, Matsuo S.

Clin Exp Nephrol 16 巻 ( 3 ) 頁： 490 - 494 2012年

Percutaneous coronary intervention with bare metal stent vs. drug-eluting stent in hemodialysis patients. 査読有り

Ishii H, Toriyama T, Aoyama T, Takahashi H, Tanaka M, Yoshikawa D, Hayashi M, Yasuda Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Circ J 76 巻 ( 7 ) 頁： 1609 - 1615 2012年

Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction. 査読有り

Suzuki Y, Ito Y, Mizuno M, Kinashi H, Sawai A, Noda Y, Mizuno T, Shimizu H, Fujita Y, Matsui K, Maruyama S, Imai E, Matsuo S, Takei Y.

Kidney int 81 巻 ( 9 ) 頁： 865 - 879 2012年

Production of cloned pigs expressing human thrombomodulin in endothelial cells. 査読有り

Satoko Yazaki, Masaki Iwamoto, Akira Onishi, Yuko Miwa, Michiko Hashimoto, Takatsugu Oishi, Shunichi Suzuki, Dai-ichiro Fuchimoto, Shoichiro Sembon, Tadashi Furusawa, DaGe Liu, Takaharu Nagasaka, Takafumi Kuzuya, Haruko Ogawa, Koji Yamamoto, Kenta Iwasaki, Masataka Haneda, Shoichi Maruyama, and Takaaki Kobayashi

Xenotransplantation 19 巻 ( 2 ) 頁： 82 - 91 2012年

Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin. 査読有り

Kato K, Kosugi T, Sato W, Arata-Kawai H, Ozaki T, Tsuboi N, Ito I, Tawada H, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.

Clin Exp Nephrol 15 巻 ( 3 ) 頁： 346 - 354 2011年

Functional consequences of inhibiting exocytosis of Weibel-Palade bodies in acute renal ischemia. 査読有り

Yasuda K, Vasko R, Hayek P, Ratliff B, Bicer H, Mares J, Maruyama S, Bertuglia S, Mascagni P, Goligorsky MS.

Am J Physiol Renal Physiol 302 巻 ( 6 ) 頁： F713 - 721 2011年

A case of perforative peritonitis caused by a piece of bamboo in a patient on peritoneal dialysis. 査読有り

Suzuki Y, Mizuno M, Nakashima R, Hiramatsu H, Toda S, Sato W, Tsuboi N, Ito I, Maruyama S, Imai E, Matsuo S, Ito Y.

Clin Exp Nephrol 15 巻 ( 6 ) 頁： 962 - 965 2011年

Validation of the equations for estimating daily sodium excretion from spot urine in patients with chronic kidney disease. 査読有り

Imai E, Yasuda Y, Horio M, Shibata K, Kato S, Mizutani Y, Imai J, Hayashi M, Kamiya H, Oiso Y, Murohara T, Maruyama S, Matsuo S.

Clin Exp Nephrol 15 巻 ( 6 ) 頁： 861 - 867 2011年

Low-serum culture system improves the adipogenic ability of visceral adipose tissue-derived stromal cells. 査読有り

Nagasaki H, Shang Q, Suzuki T, Hashimoto H, Yoshimura T, Kondo TA, Ozaki T, Maruyama S, Jomori T, Oiso Y, Hamada Y.

Cell Biol Int 35 巻 ( 6 ) 頁： 559 - 568 2011年

A Case of Acute Renal Failure Caused by Cholesterol Embolization after Carotid Artery Stenting that was Improved by Peritoneal Dialysis. 査読有り

Mizuno M, Ito Y, Hayasaki T, Suzuki Y, Hiramatsu H, Toda S, Mizuno T, Tatematsu M, Ozaki T, Yasuda Y, Sato W, Tsuboi N, Ito I, Maruyama S, Imai E, Matsuo S.

Intern Med 50 巻 ( 16 ) 頁： 1719 - 1723 2011年

Association of Adiponectin with Carotid Arteriosclerosis in Predialysis Chronic Kidney Disease. 査読有り

Hayashi M, Shibata R, Takahashi H, Ishii H, Aoyama T, Kasuga H, Yamada S, Ohashi K, Maruyama S, Matsuo S, Ouchi N, Murohara T, Toriyama T.

Am J Nephrol 34 巻 ( 3 ) 頁： 249 - 255 2011年

Tunneling nanotubes mediate rescue of prematurely senescent endothelial cells by endothelial progenitors: exchange of lysosomal pool. 査読有り

Yasuda K, Khandare A, Burianovskyy L, Maruyama S, Zhang F, Nasjletti A, Goligorsky MS.

Aging (Albany NY) 3 巻 ( 6 ) 頁： 597 - 608 2011年

Increased urethral resistance by periurethral injection of low serum cultured adipose-derived mesenchymal stromal cells in rats. 査読有り

Watanabe T, Maruyama S, Yamamoto T, Kamo I, Yasuda K, Saka Y, Ozaki T, Yuzawa Y, Matsuo S, Gotoh M.

Int J Urol 18 巻 ( 9 ) 頁： 659 - 666 2011年

Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan. 査読有り

Mizuno M, Ito Y, Tanaka A, Suzuki Y, Hiramatsu H, Watanabe M, Tsuruta Y, Matsuoka T, Ito I, Tamai H, Kasuga H, Shimizu H, Kurata H, Inaguma D, Hiramatsu T, Horie M, Naruse T, Maruyama S, Imai E, Yuzawa Y, Matsuo S.

Clin Exp Nephrol 15 巻 ( 5 ) 頁： 727 - 737 2011年

Adipose-derived stromal cells cultured in a low-serum medium, but not bone marrow-derived stromal cells, impede xenoantibody production. 査読有り

Saka Y, Furuhashi K, Katsuno T, Kim H, Ozaki T, Iwasaki K, Haneda M, Sato W, Tsuboi N, Ito Y, Matsuo S, Kobayashi T, Maruyama S.

Xenotransplantation 18 巻 ( 3 ) 頁： 196 - 208 2011年

Atrial natriuretic peptide ameliorates peritoneal fibrosis in rat peritonitis model. 査読有り

Kato H, Mizuno T, Mizuno M, Sawai A, Suzuki Y, Kinashi H, Nagura F, Maruyama S, Noda Y, Yamada K, Matsuo S, Ito Y.

Nephrol Dial Transplant 27 巻 ( 2 ) 頁： 526 - 536 2011年

Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. 査読有り

Kato N, Kosugi T, Sato W, Ishimoto T, Kojima H, Sato Y, Sakamoto K, Maruyama S, Yuzawa Y, Matsuo S, Kadomatsu K.

Am J Pathol 178 巻 ( 2 ) 頁： 572 - 579 2011年

Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney. 査読有り

Saito S, Murakumo Y, Tsuzuki T, Dambara A, Kato T, Enomoto A, Asai N, Maruyama S, Matsuo S, Takahashi M.

Hum Pathol 42 巻 ( 6 ) 頁： 848 - 858 2011年

A case of fulminant peritonitis caused by Streptococcus mitis in a patient on peritoneal dialysis. 査読有り

Mizuno M, Ito Y, Masuda T, Toda S, Hiramatsu H, Suzuki Y, Ozaki T, Yasuda Y, Ito I, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.

Intern Med 50 巻 ( 5 ) 頁： 471 - 474 2011年

Prognostic Value of Reduced Left Ventricular Ejection Fraction at Start of Hemodialysis Therapy on Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients. 査読有り

Yamada S, Ishii H, Takahashi H, Aoyama T, Morita Y, Kasuga H, Kimura K, Ito Y, Takahashi R, Toriyama T, Yasuda Y, Hayashi M, Kamiya H, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Clinical journal of the American Society of Nephrology 5 巻 ( 10 ) 頁： 1793 - 1798 2010年7月

Acute kidney injury presenting a feature of leukemic infiltration during therapy for chronic myelogenous leukemia. 査読有り

Yuzawa Y, Sato W, Masuda T, Hamada Y, Tatematsu M, Yasuda Y, Ozaki T, Ito I, Mizuno M, Maruyama S, Ito Y, Matsuo S

Internal Medicine 49 巻 ( 12 ) 頁： 1139 - 1142 2010年6月

Effects of oral cilostazol 100 mg BID on long-term patency after percutaneous transluminal angioplasty in patients with femoropopliteal disease undergoing hemodialysis: a retrospective chart review in Japanese patients. 査読有り

Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Tanaka M, Kamoi D, Kawamura Y, Yamada S, Hayashi M, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Clinical therapeutics 32 巻 ( 1 ) 頁： 24 - 33 2010年6月

Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysis. 査読有り

Fadini GP, Maruyama S, Ozaki T, Taguchi A, Meigs J, Dimmeler S, Zeiher AM, de Kreutzenberg S, Avogaro A, Nickenig G, Schmidt-Lucke C, Werner N.

PLoS One 5 巻 ( 7 ) 頁： e11488 2010年6月

Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. 査読有り

Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S.

American journal of physiology-Renal physiology 297 巻 ( 6 ) 頁： F1510 - 1517 2009年12月

Successful cross-breeding of cloned pigs expressing endo-beta-galactosidase C and human decay accelerating factor. 査読有り

Yazaki S, Iwamoto M, Onishi A, Miwa Y, Suzuki S, Fuchimoto D, Sembon S, Furusawa T, Hashimoto M, Oishi T, Liu D, Nagasaka T, Kuzuya T, Maruyama S, Ogawa H, Kadomatsu K, Uchida K, Nakao A, Kobayashi T

Xenotransplantation 16 巻 ( 6 ) 頁： 511 - 521 2009年9月

Prognostic values of C-reactive protein levels on clinical outcome after implantation of sirolimus-eluting stents in patients on hemodialysis. 査読有り

Ishii H, Toriyama T, Aoyama T, Takahashi H, Amano T, Hayashi M, Tanaka M, Kawamura Y, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Circulation: Cardiovascular Interventions 2 巻 ( 6 ) 頁： 513 - 518 2009年9月

Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic haemodialysis. 査読有り

Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Amano T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Nephrology dialysis transplantation 24 巻 ( 5 ) 頁： 1562 - 1567 2009年8月

A murine model of neonatal diabetes mellitus in Glis3-deficient mice. 査読有り

Watanabe N, Hiramatsu K, Miyamoto R, Yasuda K, Suzuki N, Oshima N, Kiyonari H, Shiba D, Nishio S, Mochizuki T, Yokoyama T, Maruyama S, Matsuo S, Wakamatsu Y, Hashimoto H.

FEBS Letter 583 巻 ( 12 ) 頁： 2108 - 2113 2009年6月

Novel culture system of mesenchymal stromal cells from human subcutaneous adipose tissue. 査読有り

Iwashima S, Ozaki T, Maruyama S, Saka Y, Kobori M, Omae K, Yamaguchi H, Niimi T, Toriyama K, Kamei Y, Torii S, Murohara T, Yuzawa Y, Kitagawa Y, Matsuo S.

Stem Cells and Development 18 巻 ( 4 ) 頁： 533 - 543 2009年5月

The growth factor midkine regulates the renin-angiotensin system in mice. 査読有り

Hobo A, Yuzawa Y, Kosugi T, Kato N, Asai N, Sato W, Maruyama S, Ito Y, Kobori H, Ikematsu S, Nishiyama A, Matsuo S, Kadomatsu K.

Journal of Clinical Investigation 19 巻 ( 6 ) 頁： 1616 - 1625 2009年5月

Lymphatic vessels develop during tubulointerstitial fibrosis. 査読有り

Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Tanaka A, Maruyama S, Takei Y, Yuzawa Y, Matsuo S.

Kidney International 75 巻 ( 8 ) 頁： 828 - 823 2009年4月

Kidney regeneration through nephron neogenesis in medaka. 査読有り

Watanabe N, Kato M, Suzuki N, Inoue C, Fedorova S, Hashimoto H, Maruyama S, Matsuo S, Wakamatsu Y.

Development Growth and Differentiation 51 巻 ( 2 ) 頁： 135 - 143 2009年2月

Removal of blood group A/B antigen in organs by ex vivo and in vivo administration of endo-beta-galactosidase (ABase) for ABO-incompatible transplantation. 査読有り

Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Li YT, Onishi A, Iwamoto M, Kuzuya T, Kadomatsu K, Uchida K, Nakao A.

Transplant immunology 20 巻 ( 3 ) 頁： 132 - 138 2008年10月

Efficiency of laparoscopic-assisted renal biopsy. 査読有り

Anas CM, Hattori R, Morita Y, Matsukawa Y, Komatsu T, Yoshino Y, Maruyama S, Yuzawa Y, Matsuo S, Gotoh M.

Clinical Nephrology 70 巻 ( 3 ) 頁： 203 - 209 2008年9月

Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients. 査読有り

Shoichi Maruyama1, Akihiko Taguchi2, Shigejiro Iwashima1, Takenori Ozaki1, Kaoru Yasuda1, Akie Kikuchi-Taura3, Toshihiro Soma3, Hideki Ishii4, Toyoaki Murohara4, Hiroshi Takahashi5, Hirotake Kasuga5, Yoshitaka Kumada6, Takanobu Toriyama5, Yasuhiko Ito1, Hirohisa Kawahara5, Yukio Yuzawa1 and Seiichi Matsuo1

Kidney international 74 巻 ( 12 ) 頁： 1603 - 1609 2008年8月

Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure. 査読有り

Ozaki T, Anas C, Maruyama S, Yamamoto T, Yasuda K, Morita Y, Ito Y, Gotoh M, Yuzawa Y, Matsuo S.

Nephrology dialysis transplantation 23 巻 ( 1 ) 頁： 110 - 119 2008年6月

Long-term outcome of percutaneous transluminal angioplasty in chronic haemodialysis patients with peripheral arterial disease. 査読有り

Kumada Y, Aoyama T, Ishii H, Tanaka M, Kawamura Y, Takahashi H, Toriyama T, Aoyama T, Yuzawa Y, Maruyama S, Matsuo S, Murohara T.

Nephrology dialysis transplantation 23 巻 ( 10 ) 頁： 3996 - 4001 2008年

Overexpression of Calmodulin in Pancreatic {beta} Cells Induces Diabetic Nephropathy. 査読有り

Yuzawa Y, Niki I, Kosugi T, Maruyama S, Yoshida F, Takeda M, Tagawa Y, Kaneko Y, Kimura T, Kato N, Yamamoto J, Sato W, Nakagawa T, Matsuo S.

Journal of the American Society of Nephrology 19 巻 ( 9 ) 頁： 1701 - 1711 2008年

Cilostazol Improves Long-Term Patency after Percutaneous Transluminal Angioplasty in Hemodialysis Patients with Peripheral Artery Disease. 査読有り

Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Yamada S, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Clinical journal of the American Society of Nephrology 3 巻 ( 4 ) 頁： 1034 - 1040 2008年

Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. 査読有り

Nishimura H, Ito Y, Mizuno M, Tanaka A, Morita Y, Maruyama S, Yuzawa Y, Matsuo S.

American journal of physiology. Renal physiology 294 巻 ( 5 ) 頁： F1084 - 1093 2008年

Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis. 査読有り

Aoyama T, Ishii H, Toriyama T, Takahashi H, Kasuga H, Murakami R, Amano T,Uetani T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T

Circulation journal 72 巻 ( 1 ) 頁： 56 - 60 2008年

High mobility group box chromosomal protein 1 in patients with renal diseases. 査読有り

Fumihiko Sato, Shoichi Maruyama, Hiroki Hayashi, Izumi Sakamoto, Shingo Yamada, Tomonori Uchimura, Yoshiki Morita, Yasuhiko Ito, Yukio Yuzawa, Ikuro Maruyama, Seiichi Matsuo

Nephron Clinical Practice 108 巻 ( 3 ) 頁： c194 - c201 2008年

Lipid droplet-associated proteins protect renal tubular cells from fatty acid-induced apoptosis. 査読有り

Urahama Y, Ohsaki Y, Fujita Y,Maruyama S, Yuzawa Y, Matsuo S, Fujimoto T.

Ameircan journal of Pathology 173 巻 ( 5 ) 頁： 1286 - 1294 2008年

Alternative strategy for overcoming ABO incompatibility. 査読有り

Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Li YT, Onishi A, Kuzuya T, Kadomatsu K, Uchida K, Nakao A.

Transplantation. 83 巻 ( 9 ) 頁： 1284 - 1286 2007年5月

Efficacy of oral nicorandil in patients with end-stage renal disease: a retrospective chart review after coronary angioplasty in Japanese patients receiving hemodialysis. 査読有り

Ishii H, Toriyama T, Aoyama T, Takahashi H, Yamada S, Kasuga H, Ichimiya S, Kanashiro M, Mitsuhashi H, Maruyama S, Matsuo S, Naruse K, Matsubara T, Murohara T.

Clin Ther. 29 巻 ( 1 ) 頁： 110 - 122 2007年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Patients receiving hemodialysis for end-stage renal disease (ESRD) are at high risk for death from ischemic heart disease (IHD). Nicorandil, a hybrid compound of adenosine triphosphate-sensitive potassium channel opener and nitric oxide donor, has been reported to improve the clinical prognosis of patients with IHD. OBJECTIVE: This study sought to investigate the efficacy of oral nicorandil in reducing the risks for cardiovascular events (CVEs) and CVE-related death in patients receiving hemodialysis for ESRD after undergoing percutaneous coronary intervention (PCI) for angina pectoris. METHODS: For this retrospective chart review, we used data from telephone interviews and medical charts from 3 hospitals in Japan. Data from patients aged <80 years who were receiving hemodialysis for ESRD and who had undergone successful PCI for angina between January 1999 and December 2004 were included in the analysis. Patients were stratified based on status of nicorandil treatment before PCI, as follows: patients receiving nicorandil 5 mg PO TID (the recommended dosage in Japan) for >1 month before PCI (nicorandil group) or those who did not receive nicorandil (control group). We investigated 6-year follow-up data on the primary end point, defined as CVEs (ie, unplanned hospital admission for worsening anginal status, or CVE-related death). The secondary end point was CVE-related death. After the data were initially analyzed, we performed a propensity-matched analysis to minimize selection bias. RESULTS: Data from 356 patients were included in the study (235 men, 121 women; mean [SD] age, 69 [9] years; mean [SD] weight, 52.3 [9.1] kg; nicorandil group, 198 patients; control group, 158 patients). According to the estimated propensity scores, 107 patients from each group were matched. There were no differences between the 2 groups in the baseline characteristics. On propensity-matched patient analysis, the estimated rates of patients who were CVE-free at 6 years were 3

DOI： 10.1016/j.clinthera.2007.12.020

PubMed

Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity: value of highly expressed hDAF for xenotransplantation. 査読有り

Liu D, Kobayashi T, Onishi A, Furusawa T, Iwamoto M, Suzuki S, Miwa Y, Nagasaka T, Maruyama S, Kadomatsu K, Uchida K, Nakao A.

Xenotransplantation. 14 巻 ( 1 ) 頁： 67 - 73 2007年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Although the successful production of alpha1,3-galactosyltransferase-knockout (GT-KO) pigs has increased expectations of clinical xenotransplantation, additional modifications of genetically engineered pigs are still being explored, because even GT-KO pigs are incapable of inhibiting the host's immunological response completely. One of the potential candidates is a complement-regulatory protein, such as human decay-accelerating factor (hDAF). However, there are few reports on how high the expression level of hDAF in pig cells would be required for suppression of complement activation. The purpose of this study was to examine the relationship between the level of hDAF expression and its inhibitory effect on human serum cytotoxicity. METHODS: An expression (pCAGGS) vector containing the hDAF gene was transfected into pig fibroblasts using an electroporation system (Gene Pulser II). Forty-eight to fifty-two hours after transfection, the cells were stained with FITC-labeled anti-hDAF antibody and then applied to the cell sorter. hDAF-transfected cells with various expression levels were collected by gating on fluorescence intensity. The level of hDAF expression was determined relative to that in human control endothelial cells. Collected cells expressing x1, x5, x10, x15 and x30 hDAF were incubated into 96-well plates for 16 h, and the cells were subjected to 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide (MTT) assay. RESULTS: hDAF expression levels in transfected cells at the time of MTT assay (16 h after sorting) were comparable to those immediately after sorting. hDAF expression in pig cells five times higher than in human endothelial cells was effective in inhibiting complement-dependent cytotoxicity of most human sera. However, 15- to 30-fold expression of hDAF was required for effective inhibition of human sera with the highest cytotoxic capacity. CONCLUSIONS: A much higher level of hDAF expression in pig cells than previously considered

DOI： 10.1111/j.1399-3089.2006.00365.x

PubMed

Effects of olprinone, a phosphodiesterase III inhibitor, on ischemic acute renal failure. 査読有り

Anas C, Ozaki T, Maruyama S, Yamamoto T, Gotoh M, Ono Y, Matsuo S

International journal of Urology 14 巻 ( 3 ) 頁： 219 - 225 2007年

Comparison of percutaneous coronary intervention with medication in the treatment of coronary artery disease in hemodialysis patients. 査読有り

Yasuda K, Kasuga H, Aoyama T, Takahashi H, Toriyama T, Kawade Y, Iwashima S, Yamada S, Kawahara H, Maruyama S, Yuzawa Y, Ishii H, Murohara T, Matsuo S

Journal of the American Society of Nephrology 17 巻 ( 8 ) 頁： 2322 - 2332 2006年8月

Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70. 査読有り

Suzuki S, Maruyama S, Sato W, Morita Y, Sato F, Miki Y, Kato S, Katsuno M, Sobue G, Yuzawa Y, Matsuo S

Kidney international 67 巻 ( 6 ) 頁： 2210 - 2220 2005年6月

Caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF. 査読有り

Fujita Y, Maruyama S, Kogo H, Matsuo S, Fujimoto T

Kidney international 66 巻 ( 5 ) 頁： 1794 - 1804 2004年11月

In vivo gene transfer of endo-beta-galactosidase C removes alphaGal antigen on erythrocytes and endothelial cells of the organs. 査読有り

Miki Y, Maruyama S, Liu D, Kobayashi T, Sato F, Shimizu H, Kato S, Sato W, Morita Y, Yuzawa Y, Muramatsu T, Matsuo S.

Xenotransplantation. 11 巻 ( 5 ) 頁： 444 - 451 2004年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The presence of Galalpha1-3Galbeta1-4GlcNAc (alphaGal) in pigs is a formidable barrier for pig-to-primate xenotransplantation. We have reported that administration of recombinant endo-beta-galactosidase C (EndoGalC) removes alphaGal on porcine erythrocytes and kidneys. The present study examined the effects of EndoGalC gene therapy on alphaGal suppression. METHODS: Naked plasmid DNA encoding Igkappa-EndoGalC was given to rats by rapid tail vein injection. The expression of alphaGal in the heart and kidney were studied by lectin staining followed by computer-assisted quantitative analyses. alphaGal expression on erythrocytes was determined by flow cytometric analyses. Enzymatic activity of EndoGalC in the serum was also determined by evaluating the capacity of EndoGalC in removing alphaGal epitopes. Elimination of alphaGal was further studied by injecting antibodies against alphaGal to rats 2 days after the gene transfer. RESULTS: Administration of 1 mg of Igkappa-EndoGalC/pCAGGS plasmid eliminated alphaGal from the vascular endothelium of the heart and kidney on day 1 and day 2. Between days 4 and 7, alphaGal started to reappear, but remained suppressed. No serious adverse effect was observed in rats treated with EndoGalC. Flow cytometric analyses showed that EndoGalC digested 97% of alphaGal on erythrocytes when measured 4 days after the gene transfer. Enzymatic activity of EndoGalC in the serum peaked on day 1, and significant levels were still observed on day 7. When antibodies against alphaGal were given, rats treated with EndoGalC showed no change, while all control rats died within 40 min. CONCLUSIONS: The present study demonstrates the potential of an EndoGalC gene transfer, using a hydrodynamics-based delivery system, in eliminating alphaGal from endothelial cells in vivo. The results also ensured that EndoGalC is not harmful suggesting that the production of pigs overexpressing EndoGalC would be a reasonable alternative to pigs deficient in alph

DOI： 10.1111/j.1399-3089.2004.00163.x

PubMed

Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4. 査読有り

Kato S, Yuzawa Y, Tsuboi N, Maruyama S, Morita Y, Matsuguchi T, Matsuo S.

J Am Soc Nephrol. 15 巻 ( 5 ) 頁： 1289 - 1299 2004年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

Acute peritonitis, in which peritoneal mesothelial cells are directly exposed to bacterial components, is a major cause of peritoneal dysfunction in continuous ambulatory peritoneal dialysis patients. We have previously shown that Toll-like receptors (TLR) are expressed in kidney cells, and LPS induces TLR4-dependent chemokine production in tubular epithelial cells. The present work was designed to investigate the involvement of TLR, especially TLR4, in the lipid A-mediated chemokine production by murine peritoneal mesothelial cells (MPMC). A primary cell culture of MPMC from C3H/HeN mice (wild-type mice; LPS sensitive) and from C3H/HeJ mice (containing a point mutation of TLR4; LPS hyposensitive) was established. The expression profile of the TLR family and their accessory molecules, CD14 and MD-2, which are requisite for the LPS signaling pathway, was examined by RT-PCR, Northern blot test, and immunohistochemical staining. Synthetic lipid A-mediated chemokine production by MPMC was studied. The involvement of MAP kinase family (ERK, JNK, and p38 mitogen-activated protein kinase) and nuclear factor (NF)-kappaB in these processes was also studied. MPMC constitutively express TLR4, CD14, and MD-2. A prominent induction of monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein (MIP)-2 by MPMC was detected after lipid A stimulation and was strictly dependent on TLR4. Furthermore, TLR4-dependent chemokine production followed by leukocyte influx into the peritoneal cavity was also confirmed in vivo after stimulation with LPS. mRNA expression of MCP-1 was abolished by NF-kappaB inhibition, but were not affected by the inhibition of ERK, JNK, or p38. As compared with MCP-1, MIP-2 mRNA expression was inhibited by a high dose of curcumin but not by NF-kappaB decoy oligodeoxynucleotide and individual inhibitions of MAP kinase, suggesting that the additional signaling pathway with NF-kappaB might be involved in mRNA expression of MIP-2. These show that TLR

PubMed

The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. 査読有り

Liu MC, Maruyama S, Mizuno M, Morita Y, Hanaki S, Yuzawa Y, Matsuo S.

Clin Exp Nephrol. 7 巻 ( 3 ) 頁： 186 - 194 2003年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Although Aristolochia manshuriensis (AM), which was incriminated in the Japanese variety of Chinese herbs nephropathy, has been recently shown to be nephrotoxic in rats, less is known about whether this toxicity is attributable to its aristolochic acids (AA). We compared the renal effect of AM with that of Akebia quinata (AQ), which has similar components to AM but is free of AA; we also compared this effect of AM with that of pure AA, and studied its possible mechanism. METHODS: In study 1, rats were divided into four groups. Each group was orally given either 0.4 g of AM, 4 g of AM, or 4 g of AQ per day, or vehicle, for 5 days. In study 2, rats were given 4 g of AM (which contained 4 mg of AA), or 4 mg of pure AA per day, or vehicle, for 5 days. Renal function, and renal histology were evaluated on day 5 in study 1 and on days 1, 3, 5, and 14 in study 2. In study 2, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) and proliferating cell nuclear antigen (PCNA) staining were also performed. In study 3, rats were treated in the same way as in study 2, but were all killed on day 5. Concentrations of AA (I + II) were measured in serum and urine in study 2, and in the kidney, lung, heart, liver, and spleen in study 3. RESULTS: In study 1, only the rats that received 4 g/day of AM developed tubular necrosis, azotemia, proteinuria, and glucosuria. In study 2, both AM- and AA-treated rats showed progressive tubular damage, decreased renal function, and increased urinary protein excretion. The degree of these alterations was comparable in the AM and AA groups. Moreover, the concentrations of AA (I + II), in serum, urine, and kidney were also comparable in the AM- and AA-treated rats. High levels of AA were detected in the lung and kidney. Apoptotic tubular cells increased on day 5 and had decreased by day 14 after the withdrawal of AM or AA. Meanwhile, proliferating tubular cells progressively increased from day 3 to day 14. C

DOI： 10.1007/s10157-003-0229-z

PubMed

Non-dipping is a potent predictor of cardiovascular mortality and is associated with autonomic dysfunction in haemodialysis patients. 査読有り

Liu M, Takahashi H, Morita Y, Maruyama S, Mizuno M, Yuzawa Y, Watanabe M, Toriyama T, Kawahara H, Matsuo S.

Nephrol Dial Transplant. 18 巻 ( 3 ) 頁： 563 - 569 2003年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Lack of nocturnal blood pressure (BP) fall (non-dipping) is common among haemodialysis (HD) patients, but much less is known regarding its association with cardiovascular (CV) disease morbidity and mortality. METHODS: Eighty HD patients initially underwent 24 h ambulatory BP monitoring (ABPM), and then they were defined as either 'dippers' (n=24, nocturnal BP fall > or = 10%) or 'non-dippers' (n=56, fall <10%). Coronary angiography was performed in the patients who had signs and/or symptoms of coronary artery disease (CAD). Twenty-four hour ambulatory ECG was recorded in 20 dippers and 20 non-dipper HD patients, and in 20 normal subjects. All patients were followed for up to 5.8 years (33.0+/-19.1 months). The outcome events studied were the hospitalisations due to CV diseases and CV death. RESULTS: Compared with dippers, non-dippers initially had a higher incidence of coronary artery stenosis (P<0.05) along with left ventricular asynergy (both Ps<0.01). The circadian rhythm of autonomic function was impaired in non-dippers. The incidences of CV events and CV deaths were 3.5 and 9 times higher in non-dippers than in dippers. The cumulative CV event-free survival and CV survival rates were lower in non-dippers than in dippers (P=0.02 and P=0.005, respectively). Based on Cox analysis, non-dipping was associated positively with CV events and CV mortality [hazard ratio (HR) 2.46, 95% CI 1.02-5.92, P=0.038 and HR 9.62, 95% CI 1.23-75.42, P=0.031, respectively]. Meanwhile, nocturnal systolic BP fall, diurnal systolic BP and diurnal pulse pressure were negatively associated with CV event/death. The clinic BP was not associated with CV event/death. CONCLUSIONS: The non-dipping phenomenon is closely related to a high incidence of CV diseases, a poor long-term survival and profound autonomic dysfunction. ABPM is useful in predicting long-term CV prognosis in HD patients.

DOI： 10.1093/ndt/18.3.563

PubMed

Proteinuria and tubulointerstitial injury: the causative factors for the progression of renal diseases. 査読有り

Matsuo S, Morita Y, Maruyama S, Manchang L, Yuzawa Y.

Contrib Nephrol. 139 巻頁： 20 - 31 2003年

P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction. 査読有り

Naruse T, Yuzawa Y, Akahori T, Mizuno M, Maruyama S, Kannagi R, Hotta N, Matsuo S.

Kidney Int. 62 巻 ( 1 ) 頁： 94 - 105 2002年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Interstitial infiltration of macrophages (Mø) is one of the main causal factors for the tubulointerstitial injury. However, precise mechanisms of Mø infiltration into tubulointerstitium have not been fully explored. The purposes of this study were to assess the role of selectins in the acute infiltration of Mø in rats with unilateral ureteral obstruction (UUO) and to evaluate the role of vasa recta, that is, whether they facilitate massive influx of Mø into the interstitium by functioning as specialized vessels. METHODS: To evaluate the role of selectins in Mø infiltration into tubulointerstitium, the expression of selectins and L-selectin ligands was examined by immunohistochemistry and immunoelectron microscopy. The functional role of P-selectin in vasa recta was studied by Stamper-Woodruff assay, in vivo p-Mø migration assay and in vivo blocking experiments with the monoclonal antibody (mAb) ARP2-4. RESULTS: Selective expression of P-selectin was detected in vasa recta as early as one hour after UUO, and the expression increased thereafter for 96 hours. In contrast, endothelial expression of L-selectin ligands and E-selectin were not detectable. In the Stamper-Woodruff assay on kidney sections of rats with UUO, the adhesion of isolated rat peritoneal Mø (p-Mø) to vasa recta was significantly inhibited by the mAb ARP2-4 (P-selectin blocker; P < 0.01), but not by mAb ARE-5 (E-selectin blocker) or rLECIg (rat L-selectin chimeric protein). In the in vivo transfer experiments with fluorescein-labeled p-Mø into rats 48 hours after UUO, labeled p-Mø had accumulated around vasa recta at three minutes and had infiltrated predominantly into the outer medulla at 180 minutes. The number of labeled p-Mø was reduced when the rats were pretreated with ARP2-4 (P < 0.01). Finally, ARP2-4 (10 mg/kg), injected 15 minutes before UUO, reduced the number of infiltrated Mø (P < 0.01). CONCLU

DOI： 10.1046/j.1523-1755.2002.00419.x

PubMed

Effects of human soluble thrombomodulin on experimental glomerulonephritis. 査読有り

Ikeguchi H, Maruyama S, Morita Y, Fujita Y, Kato T, Natori Y, Akatsu H, Campbell W, Okada N, Okada H, Yuzawa Y, Matsuo S.

Kidney Int. 61 巻 ( 2 ) 頁： 490 - 501 2002年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Coagulation and inflammation are both important processes that contribute to glomerular injury. The present study was performed to evaluate the effects of recombinant human soluble thrombomodulin (RHS-TM) in a lethal model of thrombotic glomerulonephritis and to investigate the possible mechanisms. METHODS: Thrombotic glomerulonephritis was induced in rats by administration of lipopolysaccharide and rabbit anti-rat glomerular basement membrane antibody. One hour later, RHS-TM or heparin was administered, and the histological findings, renal functions, and coagulation parameters were evaluated. To evaluate the contribution of carboxypeptidase R (CPR) to the results obtained in rats treated with RHS-TM, plasma CPR levels were measured. Then, carboxypeptidase inhibitor (CPI), which prevents the function of CPR, was administered. RESULTS: Massive glomerular thrombosis and lung hemorrhage developed within five hours of disease induction, and all rats died within 24 hours. RHS-TM (3 mg/kg) prevented the progression of the disease and all rats survived. Heparin (250 U/kg/h) showed similar anti-thrombotic effect, but induced massive hemorrhage in the lungs or stomach. RHS-TM attenuated leukocyte/neutrophil infiltration in the glomerulus but heparin did not, suggesting that RHS-TM has anti-inflammatory properties. CPR levels in plasma were about threefold higher in rats treated with RHS-TM compared to those in rats treated with heparin. Furthermore, the inhibitory effect of RHS-TM on leukocyte/neutrophil infiltration was significantly diminished by injection of CPI. CONCLUSION: RHS-TM effectively attenuates the injuries of thrombotic glomerulonephritis in rats. The results indicate that RHS-TM, in addition to its anti-thrombotic action, may exert its anti-inflammatory properties by converting proCPR to CPR, which then inactivates anaphylatoxins. RHS-TM is a potential novel therapeutic tool for thrombotic glomerular injury and related disorders.

DOI： 10.1046/j.1523-1755.2002.00160.x

PubMed

Membranous glomerulopathy with Bowman's capsular and tubular basement membrane deposits. 査読有り

Markowitz GS, Kambham N, Maruyama S, Appel GB, Cohen DJ, Kim RC, Andres GA, D'Agati VD.

Clin Nephrol. 54 巻 ( 6 ) 頁： 478 - 486 2000年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Bowman's capsular and tubular basement membrane (TBM) deposits are an extremely unusual finding in non-lupus membranous glomerulopathy (MGN). We report three atypical cases of MGN with abundant Bowman's capsular and TBM deposits. In two cases, MGN was idiopathic; in the third case, MGN occurred in the renal allograft in the setting of HCV seropositivity. In addition to the usual glomerular capillary wall deposits, immunofluorescence and electron microscopy revealed extensive immune deposits within Bowman's capsule and TBMs, predominantly at the base of parietal and tubular epithelial cells. These cases suggest a potential pathomechanism of autoantibody to secreted epithelial antigens shared by visceral, parietal, and tubular epithelial cells. In all three cases, indirect immunofluorescence was unable to detect autoantibody to normal renal epithelial or matrix constituents. Furthermore, ELISA was unable to demonstrate circulating antibody to major extracellular matrix components. The implications of these findings for the pathogenesis of MGN are explored.

PubMed

Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. 査読有り

Biancone L, Cantaluppi V, Segoloni G, Boccellino M, Del Sorbo L, Conaldi PG, Tjoelker LW, Maruyama S, Cantu E, Stern D, Andres G, Camussi G.

Transplantation. 70 巻 ( 8 ) 頁： 1198 - 1205 2000年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Platelet-activating factor (PAF) is a phospholipid mediator of inflammation which has been implicated in rejection. The interaction of anti-alpha-galactosyl natural antibodies (anti-alpha gal Abs) with endothelial cells is the initial step for the development of xenograft rejection. In our study, we stimulated porcine aortic endothelial cells (PAEC) with anti-alpha gal IgG to investigate the synthesis of PAF from PAEC and its biological consequences. METHODS AND RESULTS: PAF was extracted and chromatographically purified from cultured PAEC stimulated with baboon anti-alpha gal Abs. The Abs induced a dose-dependent synthesis of PAF peaking after 30 min of incubation, and decreasing thereafter. Concomitant cell shape change, motility, and cytoskeleton redistribution were observed. These events were prevented by addition of a panel of PAF-receptor antagonists. An SV40 T-large antigen-immortalized PAEC line was engineered to express PAF acetyl-hydrolase (PAF-AH) cDNA, the major PAF-inactivating enzyme. These transfected cells exposed to anti-alpha gal Abs showed reduced cell contraction and motility compared with empty vector-transfected cells. Moreover, in PAEC stimulated with anti-alpha gal Abs, the synthesis of PAF promoted the adhesion of a monocytic cell line as shown by the inhibitory effect of PAF-receptor antagonists and of PAF-AH expression. Finally, studies on cell monolayer demonstrated an enhanced permeability 48 hr after exposure to anti-alpha gal Abs, and this increase was prevented by PAF-inactivation and by PAF-receptor blockade. CONCLUSIONS: These results demonstrate that on stimulation with anti-alpha gal Abs, PAEC synthetize PAF which can contribute to several vascular events involved in xenograft rejection.

DOI： 10.1097/00007890-200010270-00013

PubMed

alpha-galactosyl epitopes on glycoproteins of porcine renal extracellular matrix. 査読有り

Maruyama S, Cantu E 3rd, Galili U, D'Agati V, Godman G, Stern DM, Andres G

Kidney Int. 57 巻 ( 2 ) 頁： 655 - 663 2000年2月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The pig is the donor animal of choice for human xenotransplantation. In the most relevant pig-to-baboon model, pig organs transplanted into baboons are hyperacutely rejected by natural xenoantibodies, which mainly bind to alpha-galactosyl (alphaGal) epitopes expressed at the surface of endothelial cells. Recent advances in controlling hyperacute rejection have led to improved survival of these xenografts, and it is now important to identify alphaGal binding sites in other cells and tissues that may be subject to immunologic attack. To this end, we have studied whether alphaGal antibodies bind to glycated proteins of the extracellular matrix in the kidney and other organs most likely to be used for human xenotransplantation. METHODS: High-titer anti-alphaGal antibodies, similar to human natural xenoantibodies, were prepared in baboons, and their reactivity with components of pig extracellular matrix was tested by serology and immunohistology. RESULTS: The antibodies recognized epitopes of immobilized murine, bovine or porcine thyroglobulin, laminin, heparan sulfate proteoglycans, and fibronectin. In sections of pig tissue, the antibodies bound to endothelial and certain epithelial cells, as shown in previous studies, and also to mesenchymal cells, basement membranes, and extracellular matrices, in which they colocalized with matrix glycoproteins, especially laminin and heparan sulfate proteoglycans. CONCLUSIONS: These results suggest that when pig xenografts can be made to survive for prolonged periods, the reactivity of alphaGal antibody with matrix molecules can induce basement membrane and matrix lesions similar to those induced in laboratory animals by antilaminin and antiheparan sulfate proteoglycans antibodies.

DOI： 10.1046/j.1523-1755.2000.00887.x

PubMed

Differential expression of alpha-GAL epitopes (Galalpha1-3Galbeta1-4GlcNAc-R) on pig and mouse organs. 査読有り

Tanemura M, Maruyama S, Galili U

Transplantation. 69 巻 ( 1 ) 頁： 187 - 190 2000年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Expression of the alpha-gal epitope in mice can be completely eliminated by disruption of the alpha1,3 galactosyltransferase gene. As an initial step for assessing the feasibility of this approach in the pig, it was of interest to compare the expression of alpha-gal epitopes in pig and mouse organs. METHODS: Membranes from pig and mouse organ homogenates were analyzed for alpha-gal epitope expression by Western blots, enzyme-linked immunosorbent assay (ELISA), immunostaining of tissues, and ELISA inhibition assay. RESULTS: Immunostaining of Western blots with human anti-Gal detected alpha-gal epitopes on glycoproteins from pig organs but not on glycoproteins from the corresponding mouse organs. ELISA with membrane homogenates and immunostaining of tissue sections demonstrated a much higher binding of human anti-Gal to alpha-gal epitopes on pig membranes than on mouse membranes. ELISA inhibition assay with monoclonal anti-Gal indicated that alpha-gal epitope expression in pig organs is up to 500-fold higher than in mouse organs. CONCLUSION: Expression of alpha-gal epitopes in pig organs is many fold higher than in mouse organs. The abundance of these epitopes in pigs raises the question of whether pigs can properly develop without expression of alpha-gal epitopes.

DOI： 10.1097/00007890-200001150-00034

PubMed

Interaction of baboon anti-alpha-galactosyl antibody with pig tissues. 査読有り

Maruyama S, Cantu E 3rd, DeMartino C, Wang CY, Chen J, Al-Mohanna F, NakeebSM, D'Agati V, Pernis B, Galili U, Godman G, Stern DM, Andres G

Am J Pathol. 155 巻 ( 5 ) 頁： 1635 - 1649 1999年11月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

As barriers to xenotransplantation are surmounted, such as suppression of hyperacute rejection allowing improved graft survival, it becomes important to define longer-term host-xenograft interactions. To this end we have prepared in baboons high titer anti-alpha-Galactosyl (alphaGal) and anti-porcine aortic endothelial cell antibodies, similar to human natural xenoantibodies and reactive with epitopes of thyroglobulin, laminin, and heparan sulfate proteoglycans. When injected into pigs with a protocol similar to that used in the rat to show the nephritogenic potential of heterologous anti-laminin and anti-heparan sulfate proteoglycan antibodies, baboon immunoglobulins bound first to renal vascular endothelium, and later to interstitial cells, especially fibroblasts and macrophages, and to antigens in basement membranes and extracellular matrix, where they colocalized with laminin- and heparan sulfate proteoglycan-antibodies, and with bound Griffonia simplicifolia B4. A similar binding was observed in other organs. The pigs did not develop an acute complement-dependent inflammation, but rather chronic lesions of the basement membranes and the extracellular matrix. Incubation of renal fibroblasts with baboon anti-alpha-Galactosyl antibodies resulted in increased synthesis of transforming growth factor-beta and collagen, suggesting a possible basis for the fibrotic response. The results demonstrate that in this experimental model a consequence of alphaGal antibody interaction with porcine tissues, is immunoreactivity with alphaGal on matrix molecules and interstitial cells, priming mechanisms leading to fibrosis resembling that in chronic allograft rejection. The possibility that similar lesions may develop in long-surviving pig xenografts is discussed.

DOI： 10.1016/s0002-9440(10)65479-x.

PubMed

Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme: considerations on its relevance to the pathogenesis of human idiopathic membranous glomerulonephritis. 査読有り

Maruyama S, Cantu E 3rd, Demartino C, Vladutiu A, Caldwell PR, Wang CY,D'Agati V, Godman G, Stern DM, Andres G

J Am Soc Nephrol. 10 巻 ( 10 ) 頁： 2102 - 2108 1999年10月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

In the course of studies on the humoral consequences of swine to primate xenotransplantation, the investigators induced formation of glomerular subepithelial immune deposits and tubular lesions in pigs injected with heterologous antibody to angiotensin-converting enzyme. This study describes the morphology of the lesions, discusses their mechanism, explains their relevance for understanding the pathogenesis of human idiopathic membranous glomerulonephritis, and proposes future directions for investigations.

DOI： 10.1681/ASN.V10102102

PubMed

Alpha-galactosyl antibody redistributes alpha-galactosyl at the surface of pig blood and endothelial cells. 査読有り

Maruyama S, Cantu E3rd, Pernis B, Galili U, Godman G, Stern DM, Andres G

Transpl Immunol. 7 巻 ( 2 ) 頁： 101 - 106 1999年6月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

The interaction of antibodies with cell surface antigens may induce redistribution of immune complexes, followed by antigen depletion, with increased resistance to injurious effect of antibody and complement (antigenic modulation). Human natural antibodies to Gal alpha 1,3Gal beta 1,4GlcNAc-R (alpha Gal) epitopes expressed at the surface of pig cells are a major obstacle to xenotransplantation. Recent studies have shown that these antibodies do not modulate alpha Gal, but the morphological consequences of the antigen-antibody interaction are unknown. Pig blood and endothelial cells, were exposed to baboon alpha-Gal antibodies, and studied by immunofluorescence and phase contrast microscopy, flow cytometry, and inhibition enzyme-linked immunosorbent assay. In cells studied at 4 degrees C or fixed, alpha Gal was diffusely expressed at the surface. After cross-linking at 37 degrees C, antigenic modulation did not occur, but granular redistribution of alpha Gal immune complexes was seen in all cell types. In other systems a similar redistribution is known to induce perturbation of the plasma membrane/cytoskeletal structure with changes in adhesive properties, gene regulation, and T cell activation, which could be important if pig xenografts will be made to survive for prolonged periods.

DOI： 10.1016/s0966-3274(99)80026-4

PubMed

Role of complement in acute tubulointerstitial injury of rats with aminonucleoside nephrosis. 査読有り

Nomura A, Morita Y, Maruyama S, Hotta N, Nadai M, Wang L, Hasegawa T, Matsuo S

Am J Pathol. 151 巻 ( 2 ) 頁： 539 - 547 1997年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

The present work was designed to elucidate the in vivo role of complement in the proteinuria-associated tubulointerstitial injury. Rats were intravenously injected with puromycin aminonucleoside, and massive proteinuria was observed within 5 days. Prominent tubulointerstitial injury characterized by proximal tubular degeneration, tubular dilatation, and leukocyte infiltration were observed 7 days after injection. C3 and C5b-9 were observed in the luminal side of proximal tubular cells. Renal function, assessed by inulin and para-aminohippurate clearance, was significantly decreased. To-assess the role of complement in this model, rats were injected with either cobra venom factor or soluble recombinant human complement receptor type 1 starting at day 3. These manipulations significantly improved tubulointerstitial pathology and para-aminohippurate clearance without affecting the degree of proteinuria. Deposition of C3 and C5b-9 was not detected in the kidney of rats depleted of complement by cobra venom factor. In rats treated with soluble complement receptor, C3 was still detected in the tubules, but deposition of C5b-9 was not observed. Soluble complement receptor was detected at the site of C3 deposition and in the urine. These data strongly suggest that complement plays a pivotal role in proteinuria-associated tubulointerstitial injury and that systemic complement depletion or inhibition of complement in the tubular lumen may diminish the tubulointerstitial damage.

PubMed

Detection of ret homodimers in MEN 2A-associated pheochromocytomas. 査読有り

Wada M, Asai N, Tsuzuki T, Maruyama S, Ohiwa M, Imai T, Funahashi H, Takagi H, Takahashi M

Biochem Biophys Res Commun 218 巻 ( 2 ) 頁： 606 - 609 1996年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Using transfection of NIH 3T3 cells, we have recently demonstrated that multiple endocrine neoplasia (MEN) 2A mutations activate the c-Ret protein by inducing its disulfide-linked homodimerization on the cell surface. To investigate whether the homodimers are present in original tumors, the expression of the c-Ret protein was analyzed in eight sporadic and two MEN 2A-associated pheochromocytomas, the latter two of which contained mutations in cysteine 618 or 634 of Ret. The c-Ret protein was expressed at variable levels in all pheochromocytomas examined. By labeling the c-Ret protein immunoprecipitated from tumor tissues with [gamma-32P]ATP in vitro, its homodimers were detected in pheochromocytomas from MEN 2A patients but not in a sporadic tumor. This result represents the first demonstration of Ret homodimers in original tumors.

DOI： 10.1006/bbrc.1996.0107

PubMed

Germ line mutations of the ret proto-oncogene in Japanese patients with multiple endocrine neoplasia type 2A and type 2B. 査読有り

Maruyama S, Iwashita T, Imai T, Funahashi H, Ceccherini I, Luo Y, Romeo G, Matsuo S, Matsuyama M, Takahashi M

Jpn J Cancer Res 85 巻 ( 9 ) 頁： 879 - 882 1994年9月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

We investigated mutations of the ret proto-oncogene in Japanese patients with multiple endocrine neoplasia (MEN) type 2A and type 2B. DNAs from pheochromocytomas and/or medullary thyroid carcinomas (MTCs) of five MEN 2A and three MEN 2B patients were amplified by a polymerase chain reaction (PCR) and analyzed. Tumors of four MEN 2A patients had missense mutations in Cys 634 in the extracellular domain of the ret proto-oncogene. The same mutations were detected in normal tissues of the patients, indicating that the mutations had arisen in the germ line. Using a reverse transcriptase(RT)-PCR, both normal and mutant transcripts of the ret proto-oncogene were detected in a tumor of one patient with MEN 2A mutation. In addition, three MEN 2B patients examined had the same point mutation (ATG-->ACG) at codon 918 in the tyrosine kinase domain of the ret proto-oncogene. Since all mutations identified in this study generated new restriction enzyme sites or eliminated a restriction site, the mutant alleles of affected family members could be readily detected without sequencing.

DOI： 10.1111/j.1349-7006.1994.tb02962.x

PubMed

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