Faculty Profiles - MARUYAMA, Shoichi

Papers - MARUYAMA, Shoichi

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Urinary Basigin/CD147 is a useful marker of acute T cell-mediated rejection in kidney transplant recipients Open Access

Futamura, K; Tsujita, M; Kosugi, T; Ryuge, A; Okada, M; Hiramitsu, T; Narumi, S; Takeda, A; Watarai, Y; Morozumi, K; Maruyama, S

RENAL FAILURE Vol. 47 ( 1 ) page： 2479574 2025.12

Urinary presepsin can efficiently detect T-cell-mediated rejection in patients who have undergone kidney transplantation

Kawazoe, T; Tanaka, A; Furuhashi, K; Hattori, K; Onogi, C; Owaki, A; Kato, A; Watanabe, Y; Koshi-Ito, E; Kato, N; Kosugi, T; Sano, Y; Ishida, S; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2025.4

Ameliorative Effect of an Anti-microRNA-21 Oligonucleotide on Animal and Human Models of Cystic Kidney Disease. Open Access

Noda Y, Kato N, Sato F, Suzuki Y, Tsubota S, Kitai H, Komatsu S, Tanaka A, Sato Y, Maeda K, Furuhashi K, Ishimoto T, Kosugi T, Yamaguchi T, Nagao S, Kamiya Y, Kadomatsu K, Asanuma H, Maruyama S

Kidney360 2025.4

Recurrent localized fever caused by cryoglobulinemic vasculitis following hemodialysis: A case report

Kojima, M; Shibata, M; Tomita, S; Ueda, R; Kasai, R; Yamamoto, E; Ban, AYK; Suzuki, S; Maruyama, S

CEN CASE REPORTS Vol. 14 ( 2 ) page： 151 - 156 2025.4

MPO-ANCA-positive rapidly progressive glomerulonephritis after COVID-19 vaccination during treatment of plaque psoriasis with bimekizumab

Sugiura, T; Doke, T; Tanaka, A; Sato, Y; Maeda, K; Furuhashi, K; Kato, N; Kosugi, T; Maruyama, S

CEN CASE REPORTS Vol. 14 ( 2 ) page： 194 - 199 2025.4

Establishing Cross-Specialty Expert Consensus on the Optimal Management of Hyperkalemia in Patients With Heart Failure and Chronic Kidney Disease Open Access

Kitai Takeshi, Maruyama Shoichi, Kuwahara Koichiro, Tamura Kouichi, Kinugawa Koichiro, Kashihara Naoki

Circulation Journal Vol. 89 ( 4 ) page： 470 - 478 2025.4

Language：English Publisher：The Japanese Circulation Society

Background: Patients with both heart failure (HF) and chronic kidney disease (CKD) are often treated with renin-angiotensin-aldosterone system inhibitors (RAASi), but these drugs can cause hyperkalemia, which may lead to their reduction or discontinuation, resulting in the loss of their beneficial effects. Approaches to managing RAASi-induced hyperkalemia are discordant, so in this study we aimed to establish a cross-specialty consensus on the optimal approach to managing hyperkalemia in patients with HF and CKD.Methods and Results: The study used a modified Delphi methodology. A steering committee of Japanese cardiologists and nephrologists drafted 26 consensus statements, which were used to create a survey, distributed across Japan. A total of 250 responses were received. Consensus, defined as 75% agreement, was achieved for 21/26 (81%) statements. Respondents agreed on the importance of effective hyperkalemia management based on serum potassium levels and supported the use of potassium binders (PBs), particularly novel PBs such as sodium zirconium cyclosilicate, to treat hyperkalemia while maintaining RAASi therapy. However, when potassium levels exceed 6.0 mEq/L, reduction or discontinuation of RAASi may be considered based on individual risk factors.Conclusions: This consensus provides proposals that may help support the optimal management of RAASi-induced hyperkalemia in Japanese patients with HF and CKD. It highlights the importance of treating hyperkalemia alongside optimal RAASi therapy.

DOI： 10.1253/circj.CJ-24-0844

Real-world safety profile of eculizumab in patients with paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, or generalized myasthenia gravis: an integrated analysis of post-marketing surveillance in Japan ( vol 118, pg 419, 2023)

Nishimura, JI; Kawaguchi, T; Ito, S; Murai, H; Shimono, A; Matsuda, T; Fukamizu, Y; Akiyama, H; Hayashi, H; Nakano, T; Maruyama, S

INTERNATIONAL JOURNAL OF HEMATOLOGY Vol. 121 ( 4 ) page： 560 - 562 2025.4

Temporal changes of the life and renal prognoses of patients with rapidly progressive glomerulonephritis in Japan, 1989-2019 Open Access

Nakajima, K; Kaneko, S; Usui, J; Tsuboi, N; Sugiyama, H; Maruyama, S; Isaka, Y; Narita, I; Yamagata, K

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2025.3

In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney Open Access

Tsuboi, T; Hattori, K; Ishimoto, T; Imai, K; Doke, T; Hagita, J; Ariyoshi, J; Furuhashi, K; Kato, N; Ito, Y; Kamiya, Y; Asanuma, H; Maruyama, S

MOLECULAR THERAPY NUCLEIC ACIDS Vol. 36 ( 1 ) page： 102387 2025.3

A digest of the clinical practice guideline for pediatric idiopathic nephrotic syndrome 2020 updated: medical therapy

Hamada, R; Kaku, Y; Inaba, A; Kaito, H; Kimata, T; Kondo, S; Sako, M; Sato, M; Sugimoto, K; Tanaka, S; Nagaoka, Y; Nozu, K; Hashimoto, J; Miura, K; Yamamoto, M; Kawai, F; Maruyama, S; Ishikura, K

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2025.3

Plasma Metabolite Profiles Between In-Center Daytime Extended-Hours and Conventional Hemodialysis Open Access

Takami, N; Okazaki, M; Ozeki, T; Imaizumi, T; Nishibori, N; Kurasawa, S; Hishida, M; Akiyama, S; Saito, R; Hirayama, A; Kasuga, H; Kaneda, F; Maruyama, S

KIDNEY360 Vol. 6 ( 3 ) page： 420 - 431 2025.3

Clinically meaningful eGFR slope as a surrogate endpoint differs across CKD stages and slope evaluation periods: the CKD-JAC study Open Access

Imaizumi, T; Komaba, H; Hamano, T; Nangaku, M; Murotani, K; Hasegawa, T; Fujii, N; Nitta, K; Isaka, Y; Wada, T; Maruyama, S; Fukagawa, M

CLINICAL KIDNEY JOURNAL Vol. 18 ( 2 ) page： sfae398 2025.2

Unexpected Hypotension in a Female Patient with Fabry Disease: Switching from Agalsidase α to β after Long-term ERT Open Access

Sugiura Takuya, Muto Reiko, Amano Tatsuaki, Kamiya Fumitaka, Sato Yuka, Maeda Kayaho, Saito Shoji, Katsuno Takayuki, Kato Noritoshi, Higashi Michiko, Numaguchi Atsushi, Matsuda Naoyuki, Sugiura Kazumitsu, Maruyama Shoichi

Internal Medicine Vol. advpub ( 0 ) 2025.2

Language：English Publisher：The Japanese Society of Internal Medicine

Fabry disease (FD) is a rare X-linked lysosomal storage disorder. Enzyme replacement therapies (ERT), such as agalsidase α and β, are available treatment options. While infusion-related reactions (IRRs) are known to occur at the initiation of ERT owing to immune responses, there is limited information on IRRs during long-term ERT. We report the case of a female patient with Fabry disease who developed unexpected hypotension after six years of stable treatment with agalsidase α, leading to a switch to agalsidase β. Continuous monitoring may be essential to identify potential IRRs in female patients with Fabry disease receiving long-term ERT.

DOI： 10.2169/internalmedicine.4685-24

Longitudinal impact of extended-hours hemodialysis with a liberalized diet on nutritional status and survival outcomes: findings from the LIBERTY cohort Open Access

Imaizumi, T; Okazaki, M; Hishida, M; Kurasawa, S; Nishibori, N; Nakamura, Y; Ishikawa, S; Suzuki, K; Takeda, Y; Otobe, Y; Kondo, T; Kaneda, F; Kaneda, H; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2025.1

Association between Serum Zinc Levels and Trabecular Bone Scores among Patients Undergoing Chronic Hemodialysis

Hori, M; Takahashi, H; Kondo, C; Takeda, A; Morozumi, K; Maruyama, S

AMERICAN JOURNAL OF NEPHROLOGY page： 1 - 7 2025.1

Development and validation of an algorithm for identifying patients undergoing dialysis from patients with advanced chronic kidney disease Open Access

Imaizumi, T; Yokota, T; Funakoshi, K; Yasuda, K; Hattori, A; Morohashi, A; Kusakabe, T; Shojima, M; Nagamine, S; Nakano, T; Huang, Y; Morinaga, H; Ohta, M; Nagashima, S; Inoue, R; Nakamura, N; Ota, H; Maruyama, T; Gobara, H; Endoh, A; Ando, M; Shiratori, Y; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2025.1

Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance

Furuhashi, K; Kakiuchi, M; Ueda, R; Oda, H; Ummarino, S; Ebralidze, AK; Bassal, MA; Meng, C; Sato, T; Lyu, J; Han, MG; Maruyama, S; Watanabe, Y; Sawa, Y; Kato, D; Wake, H; Reizis, B; Frangos, JA; Owens, DM; Tenen, DG; Ghiran, IC; Robson, SC; Fujisaki, J

NATURE Vol. 638 ( 8049 ) page： 206 - 215 2025.1

Randomised, double-blind study to evaluate the efficacy of rituximab in the treatment of idiopathic membranous nephropathy: A clinical trial protocol. Open Access

Shimizu S, Tanaka A, Matsuyama N, Kinoshita F, Furuhashi K, Maruyama S, PRIME Study Group

PloS one Vol. 20 ( 3 ) page： e0320070 2025

Factors associated with awareness of chronic kidney disease, and impact of awareness on renal prognosis Open Access

Hattori, A; Imaizumi, T; Toda, T; Sakurai, D; Takai, N; Miki, T; Maekawa, M; Kato, S; Hagiwara, Y; Yoshida, Y; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY 2024.12

SUrvey of renal Biopsy registry database and Anticancer dRUg therapy in Japan (SUBARU-J study) Open Access

Kuwabara, T; Miyasato, Y; Kanki, T; Mizumoto, T; Matsubara, T; Sawa, N; Sugiyama, H; Maruyama, S; Sato, H; Tsukamoto, T; Murata, T; Miyazaki, M; Imasawa, T; Mukoyama, M; Murakami, N; Jhaveri, KD; Yanagita, M; JSN Onconephrology Working Grp

CLINICAL KIDNEY JOURNAL Vol. 17 ( 12 ) page： sfae327 2024.12

Urinary presepsin is a novel biomarker capable of directly assessing monocyte/macrophage infiltration in kidney diseases Open Access

Niwa, S; Tanaka, A; Furuhashi, K; Hattori, K; Onogi, C; Sunohara, K; Owaki, A; Kato, A; Kawazoe, T; Watanabe, Y; Koshi-Ito, E; Kato, N; Kosugi, T; Maruyama, S

SCIENTIFIC REPORTS Vol. 14 ( 1 ) page： 30088 2024.12

Association between alpha blocker use and the risk of fractures in patients with chronic kidney disease: a cohort study Open Access

Sunohara, K; Onogi, C; Tanaka, A; Furuhashi, K; Matsumoto, J; Hattori, K; Owaki, A; Kato, A; Kawazoe, T; Watanabe, Y; Koshi-Ito, E; Maruyama, S

BMC NEPHROLOGY Vol. 25 ( 1 ) page： 442 2024.12

Effect of tonsillectomy combined with steroid pulse therapy upon IgA nephropathy depending on proteinuria status at diagnosis: a nationwide multicenter cohort study in Japan Open Access

Komatsu, H; Fujimoto, S; Sato, Y; Yasuda, T; Yasuda, Y; Matsuzaki, K; Hirano, K; Kawamura, T; Yokoo, T; Suzuki, Y; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 28 ( 12 ) page： 1272 - 1281 2024.12

A case of non-traumatic rectus sheath hematoma in a post-kidney transplant patient undergoing catheter embolization during anticoagulation treatment for atrial fibrillation Open Access

Fujieda, K; Saito, S; Tanaka, A; Furuhashi, K; Ozeki, T; Yasuda, Y; Sano, Y; Ishida, S; Maruyama, S

CEN CASE REPORTS Vol. 13 ( 6 ) page： 528 - 533 2024.12

Associations of anaemia and iron deficiency with health-related quality of life in patients with chronic kidney disease stage G3b-5 in Japan: sub analysis of the Reach-J CKD cohort study Open Access

Okubo, R; Ohigashi, T; Kondo, M; Tsunoda, R; Kai, HRYS; Saito, C; Hoshino, J; Okada, H; Narita, I; Maruyama, S; Wada, T; Yamagata, K

BMC NEPHROLOGY Vol. 25 ( 1 ) page： 414 2024.11

Association between proteinuria and mineral metabolism disorders in chronic kidney disease: the Japan chronic kidney disease database extension (J-CKD-DB-Ex) Open Access

Shimamoto, S; Nakahara, T; Yamada, S; Nagasu, H; Kishi, S; Nakashima, N; Tsuruya, K; Okada, H; Tamura, K; Narita, I; Maruyama, S; Yano, Y; Yokoo, T; Wada, T; Wada, J; Kanda, E; Kataoka, H; Nangaku, M; Kashihara, N; Nakano, T

SCIENTIFIC REPORTS Vol. 14 ( 1 ) page： 27481 2024.11

Physical activity and renal outcome in diabetic and non-diabetic patients with chronic kidney disease stage G3b to G5 Open Access

Hoshino, J; Ohigashi, T; Tsunoda, R; Ito, Y; Kai, H; Saito, C; Okada, H; Narita, I; Wada, T; Maruyama, S; Pisoni, R; Pecoits, R; Yamagata, K

SCIENTIFIC REPORTS Vol. 14 ( 1 ) page： 26378 2024.11

Eculizumab for adult patients with atypical haemolytic-uraemic syndrome: full dataset analysis of Japanese post-marketing surveillance Open Access

Maruyama, S; Ikeda, Y; Kaname, S; Kato, N; Matsumoto, M; Ishikawa, Y; Shimono, A; Miyakawa, Y; Nangaku, M; Shibagaki, Y; Okada, H

JOURNAL OF NEPHROLOGY Vol. 37 ( 8 ) page： 2181 - 2190 2024.11

Analysis of the impact of obesity on the prognosis of IgA nephropathy according to renal function and sex

Ariyasu, Y; Torikoshi, K; Tsukamoto, T; Yasuda, T; Yasuda, Y; Matsuzaki, K; Hirano, K; Kawamura, T; Yokoo, T; Maruyama, S; Suzuki, Y; Muso, E

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 28 ( 11 ) page： 1155 - 1167 2024.11

Safety and Tolerability of Adipose-Derived Mesenchymal Stem Cell (ADR-001) Therapy for IgA Nephropathy Open Access

Tanaka, A; Furuhashi, K; Fujieda, K; Horinouchi, A; Maeda, K; Saito, S; Mimura, T; Saka, Y; Naruse, T; Ishimoto, T; Kato, N; Kosugi, T; Kinoshita, F; Kuwatsuka, Y; Nakai, Y; Maruyama, S

KIDNEY360 Vol. 5 ( 11 ) page： 1692 - 1705 2024.11

Correlation between a 2-week change in platelet count and clinical outcomes after the initiation of ravulizumab treatment in adult patients with atypical hemolytic uremic syndrome: post-hoc analysis of the phase III trial Open Access

Matsumoto, M; Shimono, A; Yokosawa, J; Hirose, K; Wang, ED; Maruyama, S

THROMBOSIS JOURNAL Vol. 22 ( 1 ) page： 93 2024.10

C1q Binding Ability for Prior Risk Assessment of Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation Open Access

Miwa, Y; Iwasaki, K; Murotani, K; Okada, M; Nagasaka, T; Watarai, Y; Takeda, A; Shizuku, M; Ashimine, S; Ishiyama, K; Maruyama, S; Kobayashi, T

TRANSPLANT INTERNATIONAL Vol. 37 page： 13407 2024.10

A case of late-onset organizing pneumonia following COVID-19 infection in a post-kidney transplant patient Reviewed Open Access

Fujieda, K; Saito, S; Tanaka, A; Furuhashi, K; Yasuda, Y; Sano, Y; Kato, M; Maruyama, S

CEN Case Rep Vol. 13 ( 5 ) page： 346 - 350 2024.10

Association of Proteinuria Remission and Its Timing with Kidney Outcomes in Patients with Focal Segmental Glomerulosclerosis

Kawaguchi, T; Imasawa, T; Kadomura, M; Kitamura, H; Ozeki, T; Katafuchi, R; Oka, K; Furuichi, K; Isaka, Y; Sato, H; Sugiyama, H; Maruyama, S

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Vol. 35 ( 10 ) 2024.10

Tiopronin-induced Membranous Nephropathy Presenting with IgG4-predominant Staining Pattern Open Access

Yamashita Jumpei, Hirakawa Yosuke, Sato Yusuke, Abe Hiroyuki, Akiyama Shin'ichi, Maruyama Shoichi, Kume Haruki, Nangaku Masaomi

Internal Medicine Vol. 64 ( 7 ) page： 1079 - 1083 2024.9

Language：English Publisher：The Japanese Society of Internal Medicine

Tiopronin is a key drug used to treat cystinuria. A 41-year-old Japanese woman with cystinuria presented with eyelid edema and weight gain after the administration of tiopronin. Her serum albumin was 1.8 g/dL and her urinary protein level was 5.5 g/gCre. After cessation of tiopronin, she achieved remission of nephrotic syndrome (NS). Secondary NS due to tiopronin was evident based on the clinical course and laboratory values. A kidney biopsy showed membranous nephropathy (MN), and an immunofluorescence analysis revealed strong deposition of immunoglobulin G4 (IgG4). However, a previous case report of tiopronin-induced MN showed staining for IgG1 and IgG3. This case report suggests a novel etiology for tiopronin-induced MN.

DOI： 10.2169/internalmedicine.4047-24

Cardiovascular, renal and mortality risk by the KDIGO heatmap in Japan Open Access

Maruyama, S; Tanaka, T; Akiyama, H; Hoshino, M; Inokuchi, S; Kaneko, S; Shimamoto, K; Ozaki, A

CLINICAL KIDNEY JOURNAL Vol. 17 ( 8 ) page： sfae228 2024.8

Annual trends in atypical haemolytic uremic syndrome management in Japan and factors influencing early diagnosis and treatment: a retrospective study Open Access

Tatematsu, Y; Imaizumi, T; Michihata, N; Kato, N; Kumazawa, R; Matsui, H; Fushimi, K; Yasunaga, H; Maruyama, S

SCIENTIFIC REPORTS Vol. 14 ( 1 ) page： 18265 2024.8

Changes in antibody titer after four and five doses of the SARS-CoV-2 vaccine in Japanese post-kidney transplant patients Reviewed

Fujieda, K; Tanaka, A; Kikuchi, R; Takai, N; Saito, S; Yasuda, Y; Sano, Y; Kato, M; Furuhashi, K; Maruyama, S

Ther Apher Dial Vol. 28 ( 4 ) page： 489 - 498 2024.8

Importance of education on steroid cover: a case of hyponatremia after dental extraction with local anesthesia in a patient with idiopathic hypopituitarism Reviewed Open Access

Nakamura, Y; Saito, S; Okada, N; Yamakawa, T; Maruyama, S

CEN Case Rep Vol. 13 ( 4 ) page： 308 - 309 2024.8

Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease. Reviewed

Kishi S, Nakashima T, Goto T, Nagasu H, Brooks CR, Okada H, Tamura K, Nakano T, Narita I, Maruyama S, Yano Y, Yokoo T, Wada T, Wada J, Nangaku M, Kashihara N

Clin Exp Nephrol Vol. 28 ( 8 ) page： 784 - 792 2024.8

Prognosis of microscopic polyangiitis is well predictable in the first 2 weeks of treatment Open Access

Owaki, A; Tanaka, A; Furuhashi, K; Watanabe, Y; Koshi-Ito, E; Imaizumi, T; Maruyama, S

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 28 ( 7 ) page： 701 - 706 2024.7

Factors affecting the sodium-glucose cotransporter 2 inhibitors-related initial decline in glomerular filtration rate and its possible effect on kidney outcome in chronic kidney disease with type 2 diabetes: The Japan Chronic Kidney Disease Database

Kanaoka, T; Wakui, H; Yano, Y; Nagasu, H; Kanegae, H; Nangaku, M; Hirakawa, Y; Nakagawa, N; Wada, J; Tsuruya, K; Nakano, T; Maruyama, S; Wada, T; Konishi, M; Nagahiro, T; Yamagata, K; Narita, I; Yanagita, M; Terada, Y; Araki, S; Emoto, M; Okada, H; Isaka, Y; Suzuki, Y; Yokoo, T; Kataoka, H; Kanda, E; Kashihara, N; Tamura, K

DIABETES OBESITY & METABOLISM Vol. 26 ( 7 ) page： 2905 - 2914 2024.7

Detecting and exploring kidney-derived extracellular vesicles in plasma Reviewed Open Access

Komatsu, S; Kato, N; Kitai, H; Funahashi, Y; Noda, Y; Tsubota, S; Tanaka, A; Sato, Y; Maeda, K; Saito, S; Furuhashi, K; Ishimoto, T; Kosugi, T; Maruyama, S; Kadomatsu, K

Clin Exp Nephrol Vol. 28 ( 7 ) page： 617 - 628 2024.7

Ferroelectric polycrystalline Bi2SiO5 thin films on Pt-covered Si substrates prepared by pulsed laser deposition combined with post-annealing

Takahashi, H; Maruyama, S; Naganuma, H; Taniguchi, H; Takahashi, R; Yasui, S; Kaminaga, K; Matsumoto, Y

JOURNAL OF ALLOYS AND COMPOUNDS Vol. 988 2024.6

Association of calciprotein particles with serum phosphorus among patients undergoing conventional and extended-hours haemodialysis Open Access

Nishibori, N; Okazaki, M; Miura, Y; Hishida, M; Kurasawa, S; Imaizumi, T; Kato, N; Kosugi, T; Kuro-o, M; Kasuga, H; Kaneda, F; Maruyama, S

CLINICAL KIDNEY JOURNAL Vol. 17 ( 6 ) page： sfae121 2024.6

Effects of empagliflozin in patients with chronic kidney disease from Japan: exploratory analyses from EMPA-KIDNEY Open Access

Nangaku, M; Herrington, WG; Goto, S; Maruyama, S; Kashihara, N; Ueki, K; Wada, J; Watada, H; Nakashima, E; Lee, RYF; Massey, D; Mayne, KJ; Tomita, A; Haynes, R; Hauske, SJ; Kadowaki, T

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 28 ( 6 ) page： 588 - 595 2024.6

Association between Serum 25-Hydroxyvitamin D Levels and Sarcopenia in Patients Undergoing Chronic Haemodialysis

Hori, M; Takahashi, H; Kondo, C; Hayashi, F; Tokoroyama, S; Mori, Y; Tsujita, M; Shirasawa, Y; Takeda, A; Morozumi, K; Maruyama, S

AMERICAN JOURNAL OF NEPHROLOGY Vol. 55 ( 3 ) page： 399 - 405 2024.6

Clinical impact of proteinuria and hematuria remission criteria in IgA nephropathy patients defined by the Japanese Society of Nephrology Open Access

Yasuda, Y; Kaihan, AB; Kaihan, AN; Tanaka, A; Imaizumi, T; Maeda, K; Kato, N; Kosugi, T; Maruyama, S

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 39 2024.5

Evaluating the associations between compliance with CKD guideline component metrics and renal outcomes Open Access

Nyma, Z; Kitaoka, K; Yano, Y; Kanegae, H; Bayaraa, N; Kishi, S; Nagasu, H; Nakano, T; Wada, J; Maruyama, S; Nakagawa, N; Tamura, K; Yokoo, T; Yanagita, M; Narita, I; Yamagata, K; Wada, T; Tsuruya, K; Nakashima, N; Isaka, Y; Nangaku, M; Kashihara, N; Okada, H

SCIENTIFIC REPORTS Vol. 14 ( 1 ) page： 11481 2024.5

Relationship between peak aortic jet velocity and progression of aortic stenosis in patients undergoing hemodialysis. Reviewed

Kurasawa S, Imaizumi T, Kondo T, Hishida M, Okazaki M, Nishibori N, Takeda Y, Kasuga H, Maruyama S

Int J Cardiol Vol. 402 page： 131822 2024.5

SUrvey of renal Biopsy database and Anti-cancer dRUg therapy in Japan (SUBARU-J study)

Kuwabara, T; Miyasato, Y; Kanki, T; Mizumoto, T; Matsubara, T; Sawa, N; Sugiyama, H; Maruyama, S; Mukoyama, M; Murakami, N; Jhaveri, K; Yanagita, M

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 39 page： I984 - I985 2024.5

Influence of SGLT2I on tubulointerstitium in DKD patients with moderate renal dysfunction

Murakami, K; Kato, S; Sugaya, T; Kuwatsuka, Y; Ando, M; Maruyama, S

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 39 page： I110 - I111 2024.5

Interstitial fibrosis and tubular atrophy of immune checkpoint inhibitor-related interstitial nephritis associate mortality and kidney prognosis

Matsubara, T; Yamamoto, S; Kuwabara, T; Miyazawa, S; Miyasato, Y; Sawa, N; Sugiyama, H; Maruyama, S; Mukoyama, M; Yanagita, M

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 39 page： I680 - I680 2024.5

Safety and Tolerability of adipose-derived mesenchymal stem cell "ADR-001" in the treatment of immunoglobulin A nephropathy

Maruyama, S; Tanaka, A; Furuhashi, K; Fujieda, K; Maeda, K; Mimura, T; Saka, Y; Naruse, T; Ishimoto, T; Kosugi, T

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 39 page： I740 - I740 2024.5

Development and validation of risk prediction models according to different clinical settings of IgA nephropathy: nationwide multicenter cohort study

Hirano, K; Ikenoue, T; Yasuda, T; Yasuda, Y; Maruyama, S; Yokoo, T; Suzuki, H; Suzuki, Y; Fukuma, S

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 39 page： I679 - I679 2024.5

Association between anemia/iron deficiency and health-related quality of life in patients with advanced CKD: the Reach-J CKD cohort study

Okubo, R; Ohigashi, T; Kondo, M; Tsunoda, R; Kai, H; Saito, C; Okada, H; Narita, I; Hoshino, J; Maruyama, S; Wada, T; Yamagata, K

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 39 page： I2374 - I2374 2024.5

Calciprotein particles and phosphorus in conventional and extended-hours hemodialysis

Nishibori, N; Okazaki, M; Imaizumi, T; Miura, Y; Kuro-O, M; Kasuga, H; Kaneda, F; Maruyama, S

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 39 page： I2538 - I2538 2024.5

Cardiovascular, renal and mortality risk by the KDIGO risk classification: the first observational study in Japan

Maruyama, S; Akiyama, H; Ozaki, A; Tanaka, T

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 39 page： I1017 - I1019 2024.5

Characteristics of patients with aHUS who discontinued dialysis after eculizumab treatment: sub-analysis of post-marketing surveillance in Japan

Ito, S; Matsumoto, M; Shimono, A; Teranishi, H; Maruyama, S

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 39 page： I1899 - I1899 2024.5

Clinical impact of proteinuria and hematuria remission criteria in IgA nephropathy patients defined by the Japanese Society of Nephrology

Yasuda, Y; Kaihan, AB; Kaihan, AN; Tanaka, A; Imaizumi, T; Maeda, K; Kato, N; Kosugi, T; Maruyama, S

NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 39 page： I736 - I737 2024.5

Rationale and design of the Japanese Biomarkers in Nephrotic Syndrome (J-MARINE) study Reviewed

Kurasawa, S; Kato, S; Ozeki, T; Akiyama, S; Ishimoto, T; Mizuno, M; Tsuboi, N; Kato, N; Kosugi, T; Maruyama, S

Clin Exp Nephrol Vol. 28 ( 5 ) page： 431 - 439 2024.5

Macrophage-1 antigen exacerbates histone-induced acute lung injury and promotes neutrophil extracellular trap formation Reviewed Open Access

Mizuno, T; Nagano, F; Takahashi, K; Yamada, S; Fruhashi, K; Maruyama, S; Tsuboi, N

FEBS Open Bio Vol. 14 ( 4 ) page： 574 - 583 2024.4

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits and atypical pathological findings treated with corticosteroid and rituximab Reviewed Open Access

Mori, M; Tanaka, A; Maeda, K; Saito, S; Furuhashi, K; Maruyama, S

CEN Case Rep Vol. 13 ( 2 ) page： 128 - 134 2024.4

Case report: A family of atypical hemolytic uremic syndrome involving a CFH::CFHR1 fusion gene and CFHR3-1-4-2 gene duplication Reviewed Open Access

Tasaki, Y; Tsujimoto, H; Yokoyama, T; Sugimoto, N; Kitajima, S; Fujii, H; Hidaka, Y; Kato, N; Maruyama, S; Inoue, N; Wada, T

Front Immunol Vol. 15 page： 1360855 2024.3

Association between stopping renin-angiotensin system inhibitors immediately before hemodialysis initiation and subsequent cardiovascular events Reviewed Open Access

Nakamura, Y; Inaguma, D; Imaizumi, T; Kurasawa, S; Hishida, M; Okazaki, M; Fujishima, Y; Nishibori, N; Suzuki, K; Takeda, Y; Maruyama, S

Hypertens Res Vol. 47 ( 5 ) page： 1372 - 1379 2024.3

Population characteristics and diagnosis rate of chronic kidney disease by eGFR and proteinuria in Japanese clinical practice: an observational database study Reviewed Open Access

Tanaka, T; Maruyama, S; Chishima, N; Akiyama, H; Shimamoto, K; Inokuchi, S; Yokota, K; Ozaki, A

Sci Rep Vol. 14 ( 1 ) page： 5172 2024.3

特集出血傾向あるいは血栓傾向をきたす血小板減少症と血小板機能異常症【血栓傾向をきたす血小板減少症】非典型溶血性尿毒症症候群(aHUS)

加藤規利, 立枩良崇, 丸山彰一

医学のあゆみ Vol. 288 ( 8 ) page： 656 - 660 2024.2

Impact of an angulated aorto-septal relationship on cardio-cerebrovascular outcomes in patients undergoing hemodialysis. Reviewed Open Access

Nakayama T, Yamamoto J, Ozeki T, Tokoroyama S, Mori Y, Hori M, Tsujita M, Shirasawa Y, Takeda A, Kondo C, Murata M, Suzuki S, Kinoshita Y, Fukuda M, Ueki T, Ikehara N, Sugiura M, Goto T, Hashimoto H, Yajima K, Maruyama S, Koyama H, Morozumi K, Seo Y

PloS one Vol. 19 ( 2 ) page： e0298637 2024.2

Mortality and hyperkalaemia-associated hospitalisation in patients with chronic kidney disease: comparison of sodium zirconium cyclosilicate and sodium/calcium polystyrene sulfonate Reviewed Open Access

Onogi, C; Watanabe, Y; Tanaka, A; Furuhashi, K; Maruyama, S

Clin Kidney J Vol. 17 ( 2 ) page： sfae021 2024.2

Clinical characteristics of anti-GBM disease with thrombotic microangiopathy: a case report and literature review Reviewed Open Access

Nakamura, Y; Kato, N; Tatematsu, Y; Arai, Y; Mori, N; Shibata, K; Yamazaki, M; Yasui, H; Fujiwara, S; Yamakawa, T; Maruyama, S

CEN Case Rep Vol. 13 ( 1 ) page： 37 - 44 2024.2

Establishment of an adverse effect prevention protocol on plasma exchange using fresh frozen plasma prior to ABO-incompatible living donor kidney transplantation at our hospital Reviewed

Tanaka, A; Watanabe, Y; Furuhashi, K; Saito, S; Yasuda, Y; Kosugi, T; Sano, Y; Kato, M; Maruyama, S

Ther Apher Dial Vol. 28 ( 1 ) page： 152 - 157 2024.2

Clinicopathological prognostic stratification for proteinuria and kidney survival in IgA nephropathy: a Japanese prospective cohort study Reviewed Open Access

Koike, K; Kawamura, T; Hirano, K; Nishikawa, M; Shimizu, A; Joh, K; Katafuchi, R; Hashiguchi, A; Yano, Y; Matsuzaki, K; Matsushima, M; Tsuboi, N; Maruyama, S; Narita, I; Yokoo, T; Suzuki, Y

Clin Kidney J Vol. 17 ( 1 ) page： sfad294 2024.1

Overlapping Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy with Mutation in CFI in a Japanese Patient: A Case Report Open Access

Osawa Kosuke, Yamamoto Shuto, Yamano Yukiko, Kita Ayako, Okamoto Kota, Kato Noritoshi, Tatematsu Yoshitaka, Kojima Fumiyoshi, Ohya Masaki, Hara Shigeo, Murata Shin-ichi, Inoue Norimitsu, Maruyama Shoichi, Araki Shin-ichi

Internal Medicine Vol. 63 ( 12 ) page： 1777 - 1782 2024

Language：English Publisher：The Japanese Society of Internal Medicine

A 34-year-old Japanese man presented with blurred vision, headache, nausea, anemia, thrombocytopenia, and severe renal dysfunction. Thrombotic microangiopathy was initially suspected to have been caused by malignant hypertension. Antihypertensive medications did not improve his thrombocytopenia or renal dysfunction, and other diseases causing thrombotic microangiopathy were ruled out. Therefore, the patient was diagnosed with atypical hemolytic uremic syndrome. A renal biopsy revealed an overlap of thrombotic microangiopathy and C3 glomerulopathy. Genetic testing revealed c.848A>G (p.Asp283Gly), a missense heterozygous variant in the gene encoding complement factor I. Overlapping atypical hemolytic uremic syndrome and C3 glomerulopathy with complement factor I mutation is very rare, especially in Japan.

DOI： 10.2169/internalmedicine.2713-23

当院における移植後悪性腫瘍の検討 Open Access

佐野優太, 石田昇平, 佐野友康, 井上聡, 木村友和, 松川宜久, 尾関貴哉, 田中彰仁, 丸山彰一, 赤松秀輔

移植 Vol. 59 ( Supplement ) page： s326_2 - s326_2 2024

Language：Japanese Publisher：一般社団法人日本移植学会

本邦の2010年～2020年における腎移植レシピエントの死亡原因として悪性腫瘍は第1位(16.6%)であり、免疫抑制下におかれる腎移植患者は悪性腫瘍発生の高リスクとされ、悪性腫瘍の発生状況や対策は重要な課題である。2002年より2022年12月までに当院で施行した腎移植179例を対象としレトロスペクティブに検討した。悪性腫瘍は15例（8.4%）に１７種の癌が発生した。内訳は腎癌5例、大腸癌3例、膵癌2例、子宮体癌１例、前立腺癌1例、膀胱癌1例、胃癌1例、肝細胞癌1例、慢性骨髄性白血病1例、甲状腺癌1例であった。癌発症群は発症なし群と比較して、レシピエント年齢が高く、献腎移植、急性拒絶反応が多く、観察期間が長かった。また癌発症群では生存率が低かったが、生着率（death-censored）には差がなかった。癌発症例のうち癌死は4例（26.7%）であった。全例death with functioning graftであった。腎移植後は悪性腫瘍の発生率が上がり、また死亡率も高く注意が必要である。定期的な健診や予防が推奨される。当院における腎移植後悪性腫瘍の発生状況につき若干の文献的考察を加え報告する。

DOI： 10.11386/jst.59.supplement_s326_2

Open Access

CiNii Research

Complement terminal pathway inhibition reduces peritoneal injuries in a rat peritonitis model Reviewed Open Access

Kamegai, N; Kim, H; Suzuki, Y; Fukui, S; Kojima, H; Maruyama, S; Morgan, BP; Zelek, WM; Mizuno, M

Clin Exp Immunol Vol. 214 ( 2 ) page： 209 - 218 2023.12

Association between serum iron markers, iron supplementation and cardiovascular morbidity in pre-dialysis chronic kidney disease. Reviewed Open Access

Hasegawa T, Imaizumi T, Hamano T, Murotani K, Fujii N, Komaba H, Ando M, Maruyama S, Nangaku M, Nitta K, Hirakata H, Isaka Y, Wada T, Fukagawa M.

Nephrol Dial Transplant Vol. 38 ( 12 ) page： 2713 - 2722 2023.12

Current status of low-density lipoprotein apheresis treatment for patients with peripheral artery disease and chronic kidney disease in Japanese clinical database Reviewed

Watanabe, Y; Tanaka, A; Furuhashi, K; Maruyama, S

Ther Apher Dial Vol. 27 ( 6 ) page： 1000 - 1009 2023.12

Coexistence of low muscle mass and osteoporosis as a predictor of fragility fractures in long-term kidney transplant recipients Reviewed

Hori, M; Takahashi, H; Kondo, C; Matsuoka, Y; Tsujita, M; Nishihira, M; Uchida, K; Takeda, A; Morozumi, K; Maruyama, S

Am J Nephrol Vol. 54 ( 11-12 ) page： 489 - 497 2023.12

Basigin is released in extracellular vesicles derived from the renal tubular epithelium in response to albuminuria Reviewed Open Access

Watanabe, T; Maeda, K; Kato, N; Seko, H; Sugimura, M; Sato, Y; Ryuge, A; Kato, S; Kadomatsu, K; Maruyama, S; Kosugi, T

Nephrology (Carlton) Vol. 28 ( 11 ) page： 629 - 638 2023.11

Mesenchymal stem/stromal cells generated from induced pluripotent stem cells are highly resistant to senescence Reviewed Open Access

Aoi, T; Tanaka, A; Furuhashi, K; Ikeya, M; Shimizu, A; Arioka, Y; Kushima, I; Ozaki, N; Maruyama, S

Nagoya J Med Sci Vol. 85 ( 4 ) page： 682 - 690 2023.11

Relationship between the lower limit of systolic blood pressure target and kidney function decline in advanced chronic kidney disease: an instrumental variable analysis from the REACH-J CKD cohort study Reviewed

Kurasawa, S; Yasuda, Y; Kato, S; Maruyama, S; Okada, H; Kashihara, N; Narita, I; Wada, T; Yamagata, K

Hypertens Res Vol. 46 ( 11 ) page： 2478 - 2487 2023.11

Reduced Glycolytic ATP Production Is Responsible for Irreversible Podocyte Injury in Nephrotic Syndrome

Sugimura, M; Maeda, K; Sato, Y; Kato, N; Kosugi, T; Maruyama, S

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Vol. 34 ( 11 ) page： 298 - 298 2023.11

Associations of corticosteroid therapy and tonsillectomy with kidney survival in a multicenter prospective study for IgA nephropathy Reviewed Open Access

Kawamura, T; Hirano, K; Koike, K; Nishikawa, M; Shimizu, A; Joh, K; Katafuchi, R; Hashiguchi, A; Matsuzaki, K; Maruyama, S; Tsuboi, N; Narita, I; Yano, Y; Yokoo, T; Suzuki, Y

Sci Rep Vol. 13 ( 1 ) page： 18455 2023.10

Novel function of transglutaminase 2 in extracellular histone-induced acute lung injury Reviewed

Mizuno, T; Nagano, F; Ito, Y; Tatsukawa, H; Shinoda, Y; Takeuchi, T; Takahashi, K; Tsuboi, N; Nagamatsu, T; Yamada, S; Maruyama, S; Hitomi, K

Biochem Biophys Res Commun Vol. 678 page： 179 - 185 2023.10

Nishimura, JI; Kawaguchi, T; Ito, S; Murai, H; Shimono, A; Matsuda, T; Fukamizu, Y; Akiyama, H; Hayashi, H; Nakano, T; Maruyama, S

Int J Hematol Vol. 118 ( 4 ) page： 419 - 431 2023.10

The association of low serum magnesium levels with frailty among hemodialysis patients Reviewed Open Access

Hori, M; Yasuda, K; Takahashi, H; Morozumi, K; Maruyama, S

Sci Rep Vol. 13 ( 1 ) page： 14982 2023.9

Higher hemoglobin levels using darbepoetin alfa and kidney outcomes in advanced chronic kidney disease without diabetes: a prespecified secondary analysis of the PREDICT trial Reviewed Open Access

Maruyama, S; Kurasawa, S; Hayashi, T; Nangaku, M; Narita, I; Hirakata, H; Tanabe, K; Morita, S; Tsubakihara, Y; Imai, E; Akizawa, T; PREDICT Investigators

Clin Exp Nephrol Vol. 27 ( 9 ) page： 757 - 766 2023.9

Introduction

Kanetsuna, Y; Maruyama, S

NEPHRON Vol. 147 Suppl 1 page： 5 2023.8

Association of kidney function with cancer incidence and its influence on cancer risk of smoking: The Japan Multi-Institutional Collaborative Cohort Study Reviewed

Kurasawa, S; Imaizumi, T; Maruyama, S; Tanaka, K; Kubo, Y; Nagayoshi, M; Ikezaki, H; Suzuki, S; Koyama, T; Koriyama, C; Kadota, A; Katsuura-Kamano, S; Kuriki, K; Wakai, K; Matsuo, K

Int J Cancer Vol. 153 ( 4 ) page： 732 - 741 2023.8

Rationale and study design of a randomized controlled trial to investigate the renoprotective effect of canagliflozin assessed by test of renal hemodynamics in diabetic kidney disease (the FAGOTTO study) Reviewed Open Access

Kato, S; Kuwatsuka, Y; Ando, M; Tatematsu, Y; Nishibori, N; Maruyama, S

BMC Nephrol Vol. 24 ( 1 ) page： 228 2023.8

IgA-dominant glomerulonephritis with DNAJB9-negative fibrillar polytypic immunoglobulin deposits in the subepithelium Reviewed Open Access

Muto, R; Maeda, K; Fukui, S; Saito, S; Kato, N; Kosugi, T; Shimizu, A; Maruyama, S

CEN Case Rep Vol. 12 ( 3 ) page： 323 - 328 2023.8

Clinical Course of Adult FSGS and Minimal Change Disease in North American and Japanese Cohorts Reviewed Open Access

Ozeki, T; Gillespie, BW; Larkina, M; Maruyama, S; Alakwaa, F; Kretzler, M; Mariani, LH

Kidney360 Vol. 4 ( 7 ) page： 924 - 934 2023.7

Number of calcified aortic valve leaflets: natural history and prognostic value in patients undergoing haemodialysis Reviewed Open Access

Kurasawa, S; Okazaki, M; Imaizumi, T; Kondo, T; Hishida, M; Nishibori, N; Takeda, Y; Kasuga, H; Maruyama, S

Eur Heart J Cardiovasc Imaging Vol. 24 ( 7 ) page： 909 - 920 2023.6

Profiling of kidney involvement in systemic lupus erythematosus by deep learning using the National Database of Designated Incurable Diseases of Japan Reviewed Open Access

Kimura, T; Ikeuchi, H; Yoshino, M; Sakate, R; Maruyama, S; Narita, I; Hiromura, K

Clin Exp Nephrol Vol. 27 ( 6 ) page： 519 - 527 2023.6

Relapse of atypical hemolytic uremic syndrome triggered by COVID-19: a lesson for the clinical nephrologist Reviewed Open Access

Uwatoko, R; Shindo, M; Hashimoto, N; Iio, R; Ueda, Y; Tatematsu, Y; Kato, N; Maruyama, S; Hayashi, T

J Nephrol Vol. 36 ( 5 ) page： 1439 - 1442 2023.6

Peritoneal Expression of Membrane Complement Regulators Is Decreased in Peritoneal Dialysis Patients with Infected Peritonitis Reviewed Open Access

Fukui, S; Mizuno, M; Tawada, M; Suzuki, Y; Kojima, H; Matsukawa, Y; Imai, M; Kim, H; Kinashi, H; Mizutani, M; Minoshima, K; Maruyama, S; Ito, Y

Int J Mol Sci Vol. 24 ( 11 ) page： 9146 2023.5

TOPICS 腎臓内科学脂肪由来間葉系幹細胞による重症腎炎改善メカニズムの解明

古橋和拡, 田中章仁, 丸山彰一

医学のあゆみ Vol. 285 ( 8 ) page： 755 - 756 2023.5

Prognosis and incidence of infections in chronic kidney disease patients with membranous nephropathy enrolled in a large Japanese clinical claims database Reviewed Open Access

Matsuzaki, T; Watanabe, Y; Tanaka, A; Furuhashi, K; Saito, S; Maruyama, S

BMC Nephrol Vol. 24 ( 1 ) page： 126 2023.5

Excess risk of cardiovascular events in patients in the United States vs. Japan with chronic kidney disease is mediated mainly by left ventricular structure and function Reviewed Open Access

Imaizumi, T; Fujii, N; Hamano, T; Yang, W; Taguri, M; Kansal, M; Mehta, R; Shafi, T; Taliercio, J; Go, A; Rao, PDRA; Hamm, LL; Deo, R; Maruyama, S; Fukagawa, M; Feldman, HI

Kidney Int Vol. 103 ( 5 ) page： 949 - 961 2023.5

Application of a scoring system in Japanese patients diagnosed with atypical hemolytic uremic syndrome to assess the relationship between the score and clinical responses to eculizumab Reviewed Open Access

Wada, H; Teranishi, H; Shimono, A; Kato, N; Maruyama, S; Matsumoto, M

Thromb J Vol. 21 ( 1 ) page： 43 2023.4

Effect of Low-Density Lipoprotein Apheresis on Quality of Life in Patients with Diabetes, Proteinuria, and Hypercholesterolemia Reviewed

Hara, A; Wada, T; Muso, E; Maruyama, S; Kato, S; Furuichi, K; Yoshimura, K; Toyama, T; Sakai, N; Suzuki, H; Tsukamoto, T; Miyazaki, M; Sato, E; Abe, M; Shibagaki, Y; Narita, I; Goto, S; Sakamaki, Y; Yokoyama, H; Mori, N; Tanaka, S; Yuzawa, Y; Hasegawa, M; Matsubara, T; Wada, J; Tanabe, K; Masutani, K; Abe, Y; Tsuruya, K; Fujimoto, S; Iwatsubo, S; Tsuda, A; Suzuki, H; Kasuno, K; Terada, Y; Nakata, T; Iino, N; Sofue, T; Miyata, H; Nakano, T; Ohtake, T; Kobayashi, S

Blood Purif Vol. 52 ( 4 ) page： 373 - 381 2023.4

Prognostic factors of IgA nephropathy presenting with mild proteinuria at the time of diagnosis (a multicenter cohort study) Reviewed Open Access

Shirai, S; Yasuda, T; Kumagai, H; Matsunobu, H; Ichikawa, D; Shibagaki, Y; Yasuda, Y; Matsuzaki, K; Hirano, K; Kawamura, T; Suzuki, Y; Maruyama, S

Clin Exp Nephrol Vol. 27 ( 4 ) page： 340 - 348 2023.4

Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells Reviewed Open Access

Imai, K; Ishimoto, T; Doke, T; Tsuboi, T; Watanabe, Y; Katsushima, K; Suzuki, M; Oishi, H; Furuhashi, K; Ito, Y; Kondo, Y; Maruyama, S

Mol Ther Nucleic Acids Vol. 31 page： 139 - 150 2023.3

Serum and plasma levels of Ba, but not those of soluble C5b-9, might be affected by renal function in chronic kidney disease patients Reviewed Open Access

Yamane, R; Yasuda, Y; Oshima, A; Suzuki, Y; Kojima, H; Kim, H; Fukui, S; Maruyama, S; Ito, Y; Mizuno, M

BMC Nephrol Vol. 24 ( 1 ) page： 26 2023.2

Non-A Blood Type Is a Risk Factor for Poor Cardio-Cerebrovascular Outcomes in Patients Undergoing Dialysis Reviewed Open Access

Nakayama, T; Yamamoto, J; Ozeki, T; Tsuruta, Y; Yokoi, M; Aoi, T; Mori, Y; Hori, M; Tsujita, M; Shirasawa, Y; Kondo, C; Yasuda, K; Murata, M; Kinoshita, Y; Suzuki, S; Fukuda, M; Yamazaki, C; Ikehara, N; Sugiura, M; Goto, T; Hashimoto, H; Yajima, K; Maruyama, S; Morozumi, K; Seo, Y

Biomedicines Vol. 11 ( 2 ) page： 592 2023.2

Assessment of Antibody-Titer Changes after Second and Third Severe Acute Respiratory Syndrome Coronavirus 2 mRNA Vaccination in Japanese Post-Kidney-Transplant Patients Reviewed Open Access

Fujieda, K; Tanaka, A; Kikuchi, R; Takai, N; Saito, S; Yasuda, Y; Fujita, T; Kato, M; Furuhashi, K; Maruyama, S

Vaccines (Basel) Vol. 11 ( 1 ) page： 134 2023.1

腎移植後ガンシクロビル耐性サイトメガロウイルス感染となった2例

佐野優太, 石田昇平, 佐野友康, 加藤真史, 田中章仁, 齋藤尚二, 安田宜成, 丸山彰一, 赤松秀輔

移植 Vol. 58 ( Supplement ) page： s274_2 - s274_2 2023

Language：Japanese Publisher：一般社団法人日本移植学会

サイトメガロウイルス(CMV)感染症は最も頻度が高く重要な移植後ウイルス感染症である。治療にはまずガンシクロビル(GCV)、バルガンシクロビル(VGCV)が使用されるが、今回移植後GCV耐性CMV感染となり、ホスカルネットナトリウムにて治癒した2例を経験したので報告する。症例1:50代男性。X-17年より血液透析導入。Caroli病による頻回の胆管炎で入院を繰り返していた。ドナーは50代女性。原疾患は脳出血。脳死下肝腎同時移植施行。S-Cre1.00mg/dl前後で安定し、特記合併症なく術後約一か月で退院となった。CMV抗体陽性。術後7か月後、CMV感染となりVGCV内服開始。内服開始後もCMV感染の改善見られず、GCV耐性が判明しホスカルネットナトリウム投与開始。特記合併症なく治癒した。症例2:40代男性。X年、悪性高血圧による慢性腎不全にて血液透析導入。母親をドナーとした生体腎移植施行。S-Cre2.00mg/dl前後で安定し、特記合併症なく術後約一か月で退院となった。レシピエントCMV抗体陰性、ドナーCMV抗体陽性であったためVGCV予防内服を開始した。術後6か月後、CMV感染となりVGCV内服を治療量へ増やした。内服開始後もCMV感染の改善見られず、GCV耐性が判明しホスカルネットナトリウム投与開始。特記合併症なく治癒した。今回、移植後GCV耐性CMVに対してホスカルネットナトリムを使用し、特記問題なく治癒した症例を経験したので若干の文献的考察を加えて報告する。

DOI： 10.11386/jst.58.supplement_s274_2

CiNii Research

生体腎移植ドナーにおける腎提供後のフォローアップの重要性

安田宜成, 田中章仁, 齋藤尚二, 加藤規利, 小杉智規, 佐野優太, 加藤真史, 丸山彰一

移植 Vol. 58 ( Supplement ) page： s248_3 - s248_3 2023

Language：Japanese Publisher：一般社団法人日本移植学会

【目的】日本透析医学会の統計調査では慢性維持透析患者107 人（0.043％）が腎移植ドナーとしての腎提供ありと回答した。名古屋大学の生体腎移植ドナーの予後を調査した。【方法】対象は1998年以降に名古屋大学で生体腎移植のため腎提供したドナー167名。内2020～22年に受診した138名の最終診察時のCKD重症度分類を調査した。受診がない29名について背景を調査した。【結果】生体腎移植ドナーのGFR区分はG2:18名（13.0％）、G3a:74名（53.6％）、G3b:44名（31.9％）G4:2名（1.5％）、蛋白尿区分はA1:103名（74.6％）、A2:25名（18.1％）、A3:5名（3.6％）、未測定5名（3.6％）であった。G4の1名は73歳男性で腎提供前の2回の実測Ｃｃｒ平均は126.15ｍＬ/分であったが腎提供後に高血圧を合併し、腎提供後15年以上の経過で大動脈瘤手術を受けていた。残る1名は80歳女性で腎提供前の実測GFRは113.9で、腎提供後も10年以上安定していたが、急性腎障害後に腎機能が低下した。A3の4名では、腎提供前の高血圧合併2名、肥満1名だった。

DOI： 10.11386/jst.58.supplement_s248_3

CiNii Research

Efficacy of On-line Hemodiafiltration for Rhabdomyolysis Presenting with Acute Kidney Injury Due to Unexpected Drug Abuse Open Access

Sato Naokazu, Inagaki Koji, Takanashi Masahiro, Muto Reiko, Kato Noritoshi, Maruyama Shoichi, Akahori Toshiyuki

Internal Medicine Vol. 62 ( 19 ) page： 2865 - 2870 2023

Language：English Publisher：The Japanese Society of Internal Medicine

Myoglobin is a well-known cause of acute kidney injury (AKI) due to rhabdomyolysis. However, whether or not removing serum myoglobin by on-line hemodiafiltration (OHDF) improves the kidney function remains unclear. We herein report a patient with a history of methamphetamine abuse who developed AKI due to rhabdomyolysis. A urinalysis and blood collection results obtained before and after OHDF demonstrated that OHDF improved the kidney function by removing a large amount of serum myoglobin rather than via urinary excretion. In conclusion, OHDF may prevent AKI progression effectively when the urine volume is insufficient.

DOI： 10.2169/internalmedicine.1107-22

Recurrent Cerebrovascular Complications under Enzyme Replacement Therapy in a Patient with Fabry Disease on Peritoneal Dialysis Open Access

Muto Reiko, Suzuki Yasuhiro, Shimizu Hideaki, Yasuda Kaoru, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko, Mizuno Masashi

Internal Medicine Vol. 62 ( 3 ) page： 565 - 569 2023

Language：English Publisher：The Japanese Society of Internal Medicine

Fabry disease is an X-linked lysosomal storage disorder due to mutations in the alpha-galactosidase A gene, which leads to the accumulation of globotriaosylceramide in various organs. In Fabry disease with end-stage renal disease (ESRD), cerebrovascular events are lethal, even with enzyme replacement therapy (ERT). However, the utility of biomarkers to evaluate the ERT response is unclear. We herein report a case of recurrent cerebrovascular complications under ERT in a Fabry disease patient, progressing to ESRD on peritoneal dialysis. Further studies are warranted, but Fabry disease patients with ESRD receiving ERT might need careful long-term follow-up in cases with cerebrovascular manifestations.

DOI： 10.2169/internalmedicine.0185-22

The Impact of Liver Chemistries on Respiratory Failure among Hemodialysis Patients with COVID-19 during the Omicron Wave Open Access

Hori Mayuko, Yasuda Kaoru, Takahashi Hiroshi, Aoi Tomonori, Mori Yoshiko, Tsujita Makoto, Shirasawa Yuichi, Kondo Chika, Hashimoto Takashi, Koyama Hiroichi, Morozumi Kunio, Maruyama Shoichi

Internal Medicine Vol. 62 ( 18 ) page： 2617 - 2625 2023

Language：English Publisher：The Japanese Society of Internal Medicine

Objective Although the coronavirus disease 2019 (COVID-19) Omicron variant causes less severe symptoms than previous variants, early indicators for respiratory failure are needed in hemodialysis patients, who have a higher mortality rate than the general population. Liver chemistries are known to reflect the severity of COVID-19 in the general population. This study explored the early indicators for worsened respiratory failure based on patient characteristics, including liver chemistries. Methods This retrospective study included 117 patients admitted for COVID-19 during the Omicron wave. Respiratory failure was defined as oxygen requirement during treatment. Information on the symptoms and clinical characteristics, including liver chemistries [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)], at admission was collected. Results Thirty-five patients (29.9%) required oxygen supply during treatment. In the multivariate logistic regression analyses, AST [odds ratio (OR) 1.06, 95% confidence interval (CI) 1.00-1.13, p=0.029], ALT (OR 1.09, 95% CI 1.02-1.18, p=0.009), and moderate COVID-19 illness (Model including AST, OR 6.95, 95% CI 2.23-23.17, p<0.001; Model including ALT, OR 7.19, 95% CI 2.21-25.22, p=0.001) were independent predictors for respiratory failure. Based on the cutoff values determined by the receiver operating characteristic curve, higher AST (≥23 IU/L) and ALT levels (≥14 IU/L) were also independently associated with respiratory failure (higher AST: 64.3% vs. 18.8%, OR 3.44, 95% CI 1.08-11.10, p=0.035; higher ALT: 48.8% vs. 19.7%, OR 4.23, 95% CI 1.34-14.52, p=0.013, respectively). Conclusion The measurement of AST and ALT levels at baseline may help predict oxygen requirement in hemodialysis patients with COVID-19.

DOI： 10.2169/internalmedicine.2115-23

Long-term peritoneal dialysate exposure modulates expression of membrane complement regulators in human peritoneal mesothelial cells Reviewed Open Access

Kobayashi, K; Ozeki, T; Kim, H; Imai, M; Kojima, H; Iguchi, D; Fukui, S; Suzuki, M; Suzuki, Y; Maruyama, S; Ito, Y; Mizuno, M

Front Med Vol. 9 page： 972592 2022.12

Deep learning analysis of clinical course of primary nephrotic syndrome: Japan Nephrotic Syndrome Cohort Study (JNSCS) Reviewed Open Access

Kimura, T; Yamamoto, R; Yoshino, M; Sakate, R; Imai, E; Maruyama, S; Yokoyama, H; Sugiyama, H; Nitta, K; Tsukamoto, T; Uchida, S; Takeda, A; Sato, T; Wada, T; Hayashi, H; Akai, Y; Fukunaga, M; Tsuruya, K; Masutani, K; Konta, T; Shoji, T; Hiramatsu, T; Goto, S; Tamai, H; Nishio, S; Nagai, K; Yamagata, K; Yasuda, H; Ichida, S; Naruse, T; Nishino, T; Sobajima, H; Akahori, T; Ito, T; Terada, Y; Katafuchi, R; Fujimoto, S; Okada, H; Mimura, T; Suzuki, S; Saka, Y; Sofue, T; Kitagawa, K; Fujita, Y; Mizutani, M; Kashihara, N; Sato, H; Narita, I; Isaka, Y

Clin Exp Nephrol Vol. 26 ( 12 ) page： 1170 - 1179 2022.12

Predicting oxygen requirements in patients with coronavirus disease 2019 using an artificial intelligence-clinician model based on local non-image data Reviewed Open Access

Muto, R; Fukuta, S; Watanabe, T; Shindo, Y; Kanemitsu, Y; Kajikawa, S; Yonezawa, T; Inoue, T; Ichihashi, T; Shiratori, Y; Maruyama, S

Front Med Vol. 9 page： 1042067 2022.11

Systematic characterization of seed overlap microRNA cotargeting associated with lupus pathogenesis Reviewed Open Access

Kitai, H; Kato, N; Ogami, K; Komatsu, S; Watanabe, Y; Yoshino, S; Koshi, E; Tsubota, S; Funahashi, Y; Maeda, T; Furuhashi, K; Ishimoto, T; Kosugi, T; Maruyama, S; Kadomatsu, K; Suzuki, HI

BMC Biol Vol. 20 ( 1 ) page： 248 2022.11

Influence of COVID-19 on the 10-year carbon footprint of the Nagoya University Hospital and medical research centre Reviewed Open Access

Morooka, H; Yamamoto, T; Tanaka, A; Furuhashi, K; Miyagawa, Y; Maruyama, S

Global Health Vol. 18 ( 1 ) page： 92 2022.11

Identifying high-risk population of depression: association between metabolic syndrome and depression using a health checkup and claims database Reviewed Open Access

Imaizumi, T; Toda, T; Maekawa, M; Sakurai, D; Hagiwara, Y; Yoshida, Y; Ando, M; Maruyama, S

Sci Rep Vol. 12 ( 1 ) page： 18577 2022.11

Impact of Urinary Protein Examination on Early Diagnosis of CKD: A Nationwide Hospital-Based Observational Study in Japan, REAL-CKD

Maruyama, S; Tanaka, T; Takeda, M; Morita, N; Yajima, T

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Vol. 33 ( 11 ) page： 301 - 301 2022.11

Acute Kidney Injury and Remission of Proteinuria in Minimal Change Disease. Reviewed Open Access

Yamamoto, R; Imai, E; Maruyama, S; Yokoyama, H; Sugiyama, H; Takeda, A; Uchida, S; Tsukamoto, T; Tsuruya, K; Akai, Y; Nitta, K; Fukunaga, M; Hayashi, H; Shoji, T; Masutani, K; Konta, T; Katafuchi, R; Nishio, S; Wada, T; Goto, S; Tamai, H; Shirasaki, A; Nagai, K; Nishino, T; Yamagata, K; Kazama, JJ; Hiromura, K; Yasuda, H; Sofue, T; Fujimoto, S; Mizutani, M; Naruse, T; Hiramatsu, T; Morozumi, K; Sobajima, H; Saka, Y; Ishimura, E; Ito, T; Ichikawa, D; Shigematsu, T; Sato, H; Narita, I; Yoshitaka, I

Kidney Int Rep Vol. 7 ( 10 ) page： 2283 - 2288 2022.10

A nationwide analysis of renal and patient outcomes for adults with lupus nephritis in Japan Reviewed

Ikeuchi, H; Sugiyama, H; Sato, H; Yokoyama, H; Maruyama, S; Mukoyama, M; Hayashi, H; Tsukamoto, T; Fukuda, M; Yamagata, K; Ishikawa, E; Uchida, K; Kamijo, Y; Nakagawa, N; Tsuruya, K; Nojima, Y; Hiromura, K

Actions Vol. 26 ( 9 ) page： 898 - 908 2022.9

Impact of etelcalcetide on fibroblast growth factor-23 and calciprotein particles in patients with secondary hyperparathyroidism undergoing haemodialysis Reviewed Open Access

Hashimoto, Y; Kato, S; Kuro-o, M; Miura, Y; Itano, Y; Ando, M; Kuwatsuka, Y; Maruyama, S

Nephrology (Carlton) Vol. 27 ( 9 ) page： 763 - 770 2022.9

New-onset and relapse of nephrotic syndrome following COVID-19 vaccination: a questionnaire survey in Japan Reviewed Open Access

Nakagawa, N; Maruyama, S; Kashihara, N; Narita, I; Isaka, Y

Vol. 26 ( 9 ) page： 909 - 916 2022.9

Mesenchymal stem cells exert renoprotection via extracellular vesicle-mediated modulation of M2 macrophages and spleen-kidney network Reviewed Open Access

Shimamura, Y; Furuhashi, K; Tanaka, A; Karasawa, M; Nozaki, T; Komatsu, S; Watanabe, K; Shimizu, A; Minatoguchi, S; Matsuyama, M; Sawa, Y; Tsuboi, N; Ishimoto, T; Suzuki, HI; Maruyama, S

Vol. 5 ( 1 ) page： 753 2022.7

Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study Reviewed Open Access

Yamamoto, R; Imai, E; Maruyama, S; Yokoyama, H; Sugiyama, H; Takeda, A; Uchida, S; Tsukamoto, T; Tsuruya, K; Akai, Y; Nitta, K; Fukunaga, M; Hayashi, H; Masutani, K; Wada, T; Konta, T; Katafuchi, R; Nishio, S; Goto, S; Tamai, H; Shirasaki, A; Shoji, T; Nagai, K; Nishino, T; Yamagata, K; Kazama, JJ; Hiromura, K; Yasuda, H; Mizutani, M; Naruse, T; Hiramatsu, T; Morozumi, K; Sobajima, H; Saka, Y; Ishimura, E; Ichikawa, D; Shigematsu, T; Sofue, T; Fujimoto, S; Ito, T; Sato, H; Narita, I; Isaka, Y

Sci Rep Vol. 12 ( 1 ) page： 9782 2022.6

Mortality and Cardiovascular Events in Patients With Chronic Kidney Disease and Sleep Apnea Syndrome Open Access

Watanabe, Y; Tanaka, A; Furuhashi, K; Saito, S; Maruyama, S

FRONTIERS IN MEDICINE Vol. 9 page： 899359 2022.5

Protocol for a Phase 1, Open-Label, Multiple-Center, Dose-Escalation Study to Evaluate the Safety and Tolerability of ADR-001 in the Treatment of Immunoglobulin A Nephropathy Open Access

Tanaka, A; Furuhashi, K; Fujieda, K; Maeda, K; Saito, S; Mimura, T; Saka, Y; Naruse, T; Ishimoto, T; Kosugi, T; Kinoshita, F; Kuwatsuka, Y; Shimizu, S; Nakai, Y; Maruyama, S

FRONTIERS IN MEDICINE Vol. 9 page： 883168 2022.5

Effects of bone turnover status on the efficacy and safety of denosumab among haemodialysis patients Reviewed Open Access

Hori, M; Yasuda, K; Takahashi, H; Kondo, C; Shirasawa, Y; Ishimaru, Y; Sekiya, Y; Morozumi, K; Maruyama, S

Sci Rep Vol. 12 ( 1 ) page： 7781 2022.5

Antibody response to double SARS-CoV-2 mRNA vaccination in Japanese kidney transplant recipients Reviewed Open Access

Fujieda, K; Tanaka, A; Kikuchi, R; Takai, N; Saito, S; Yasuda, Y; Fujita, T; Kato, M; Furuhashi, K; Maruyama, S

Sci Rep Vol. 12 ( 1 ) page： 6850 2022.4

Time to remission of proteinuria and incidence of relapse in patients with steroid-sensitive minimal change disease and focal segmental glomerulosclerosis: the Japan Nephrotic Syndrome Cohort Study. Reviewed

Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Takeda A, Tsukamoto T, Uchida S, Tsuruya K, Shoji T, Hayashi H, Akai Y, Fukunaga M, Konta T, Nishio S, Goto S, Tamai H, Nagai K, Katafuchi R, Masutani K, Wada T, Nishino T, Shirasaki A, Sobajima H, Nitta K, Yamagata K, Kazama JJ, Hiromura K, Yasuda H, Mizutani M, Akahori T, Naruse T, Hiramatsu T, Morozumi K, Mimura T, Saka Y, Ishimura E, Hasegawa H, Ichikawa D, Shigematsu T, Sato H, Narita I, Isaka Y, Japan Nephrotic Syndrome Cohort Study investigators.

J Nephrol Vol. 35 ( 4 ) page： 1135 - 1144 2022.4

A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts. Reviewed

Minatoguchi S, Saito S, Furuhashi K, Sawa Y, Okazaki M, Shimamura Y, Kaihan AB, Hashimoto Y, Yasuda Y, Hara A, Mizutani Y, Ando R, Kato N, Ishimoto T, Tsuboi N, Esaki N, Matsuyama M, Shiraki Y, Kobayashi H, Asai N, Enomoto A, Maruyama S

Sci Rep Vol. 12 ( 1 ) page： 5389 2022.3

Biopsy-proven CKD etiology and outcomes: Chronic Kidney Disease Japan Cohort (CKD-JAC) study. Reviewed

Hamano T, Imaizumi T, Hasegawa T, Fujii N, Komaba H, Ando M, Nangaku M, Nitta K, Hirakata H, Isaka Y, Wada T, Maruyama S, Fukagawa M

Nephrol Dial Transplant Vol. 38 ( 2 ) page： 384 - 395 2022.3

Lateral spine dual-energy X-ray absorptiometry and the risk of fragility fractures in long-term kidney graft recipients Reviewed

Hori Mayuko, Yasuda Kaoru, Takahashi Hiroshi, Matsuoka Yutaka, Tsujita Makoto, Nishihira Morikuni, Uchida Kazuharu, Morozumi Kunio, Maruyama Shoichi

Related information Vol. 26 ( 7 ) page： 724 - 732 2022.3

Impact of left ventricular hypertrophy on clinical outcomes in patients with dialysis: a single-center study in Japan Reviewed

Nakayama Takafumi, Yamamoto Junki, Ozeki Toshikazu, Yasuda Kaoru, Yamazaki Chikao, Ito Tsuyoshi, Goto Toshihiko, Maruyama Shoichi, Morozumi Kunio, Seo Yoshihiro

J Med Ultrason (2001) Vol. 49 ( 2 ) page： 241 - 252 2022.3

Long-term Effectiveness of a Primary Care Practice Facilitation Program for Chronic Kidney Disease Management: An Extended Follow-up of a Cluster-Randomized FROM-J Study. Reviewed

Imasawa T, Saito C, Kai H, Iseki K, Kazama JJ, Shibagaki Y, Sugiyama H, Nagata D, Narita I, Nishino T, Hasegawa H, Honda H, Maruyama S, Miyazaki M, Mukoyama M, Yasuda H, Wada T, Ishikawa Y, Tsunoda R, Nagai K, Okubo R, Kondo M, Hoshino J, Yamagata K

Nephrol Dial Transplant Vol. 38 ( 1 ) page： 158 - 166 2022.2

Clustering phosphate and iron-related markers and prognosis in dialysis patients Reviewed Open Access

Morooka, H; Tanaka, A; Inaguma, D; Maruyama, S

Global Health Vol. 15 ( 2 ) page： 328 - 337 2022.2

Favorable therapeutic efficacy of low-density lipoprotein apheresis for nephrotic syndrome with impaired renal function. Reviewed

Muso E, Sakai S, Ogura Y, Yukawa S, Nishizawa Y, Yorioka N, Saito T, Mune M, Sugiyama S, Iino Y, Hirano T, Hattori M, Watanabe T, Yokoyama H, Sato H, Uchida S, Wada T, Shoji T, Oda H, Mori K, Kimura H, Ito O, Nishiyama A, Maruyama S, Inagi R, Fujimoto S, Tsukamoto T, Suzuki Y, Honda H, Babazono T, Tsuruya K, Yuzawa Y

Ther Apher Dial Vol. 26 ( 1 ) page： 220 - 228 2022.2

Sex differences in clinical outcomes in Japanese incident dialysis patients: a prospective observational multicenter study Reviewed

Kozaki Yohei, Morinaga Takatoshi, Fukatsu Atsushi, Ito Takeshi, Ishimoto Takuji, Kosugi Tomoki, Inaguma Daijo, Tamai Hirofumi, Maruyama Shoichi

Clin Exp Nephrol Vol. 26 ( 5 ) page： 466 - 475 2022.1

Expression of a Crry/p65 is reduced in acute lung injury induced by extracellular histones Reviewed

Nagano Fumihiko, Mizuno Tomohiro, Imai Masaki, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Mizuno Masashi

FEBS Open Bio Vol. 12 ( 1 ) page： 192 - 202 2022.1

Increased Monocyte/Lymphocyte Ratio as Risk Marker for Cardiovascular Events and Infectious Disease Hospitalization in Dialysis Patients. Reviewed

Muto R, Kato S, Lindholm B, Qureshi AR, Ishimoto T, Kosugi T, Maruyama S

Blood Purif Vol. 51 ( 9 ) page： 747 - 755 2021.11

The 30-year Natural History of Non-classic Fabry Disease with an R112H Mutation. Reviewed

Muto R, Inagaki K, Kato N, Maruyama S, Akahori T

Intern Med Vol. 61 ( 11 ) page： 1727 - 1730 2021.11

X-chromosome inactivation patterns in females with Fabry disease examined by both ultra-deep RNA sequencing and methylation-dependent assay Reviewed

Rossanti Rini, Nozu Kandai, Fukunaga Atsushi, Nagano China, Horinouchi Tomoko, Yamamura Tomohiko, Sakakibara Nana, Minamikawa Shogo, Ishiko Shinya, Aoto Yuya, Okada Eri, Ninchoji Takeshi, Kato Noritoshi, Maruyama Shoichi, Kono Keiji, Nishi Shinichi, Iijima Kazumoto, Fujii Hideki

Clin Exp Nephrol Vol. 25 ( 11 ) page： 1224 - 1230 2021.11

Kidney Outcomes Associated With SGLT2 Inhibitors Versus Other Glucose-Lowering Drugs in Real-world Clinical Practice: The Japan Chronic Kidney Disease Database. Reviewed

Nagasu H, Yano Y, Kanegae H, Heerspink HJL, Nangaku M, Hirakawa Y, Sugawara Y, Nakagawa N, Tani Y, Wada J, Sugiyama H, Tsuruya K, Nakano T, Maruyama S, Wada T, Yamagata K, Narita I, Tamura K, Yanagita M, Terada Y, Shigematsu T, Sofue T, Ito T, Okada H, Nakashima N, Kataoka H, Ohe K, Okada M, Itano S, Nishiyama A, Kanda E, Ueki K, Kashihara N

Diabetes Care Vol. 44 ( 11 ) page： 2542 - 2551 2021.11

Abnormal magnesium levels and their impact on death and acute kidney injury in critically ill children Reviewed

Morooka Hikaru, Tanaka Akihito, Kasugai Daisuke, Ozaki Masayuki, Numaguchi Atsushi, Maruyama Shoichi

Pediatr Nephrol Vol. 37 ( 5 ) page： 1157 - 1165 2021.10

Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis Reviewed Open Access

Ryuge, A; Kosugi, T; Maeda, K; Banno, R; Gou, Y; Zaitsu, K; Ito, T; Sato, Y; Hirayama, A; Tsubota, S; Honda, T; Nakajima, K; Ozaki, T; Kondoh, K; Takahashi, K; Kato, N; Ishimoto, T; Soga, T; Nakagawa, T; Koike, T; Arima, H; Yuzawa, Y; Minokoshi, Y; Maruyama, S; Kadomatsu, K

JCI Insight Vol. 6 ( 20 ) page： e142464 2021.10

Effect of body mass index on the association between alcohol consumption and the development of chronic kidney disease Reviewed

Hashimoto Yusaku, Imaizumi Takahiro, Kato Sawako, Yasuda Yoshinari, Ishimoto Takuji, Kawashiri Hiroaki, Hori Akihiro, Maruyama Shoichi

Sci Rep Vol. 11 ( 1 ) page： 20440 2021.10

Epidemiology and temporal changes in the prognosis of rapidly progressive glomerulonephritis in Japan: a nationwide 1989-2015 survey Reviewed

Kaneko Shuzo, Yamagata Kunihiro, Usui Joichi, Tsuboi Naotake, Sugiyama Hitoshi, Maruyama Shoichi, Narita Ichiei

Clin Exp Nephrol Vol. 26 ( 3 ) page： 234 - 246 2021.10

Kidney biopsy guidebook 2020 in Japan (vol 25, pg 325, 2021) Reviewed

Ubara Yoshifumi, Kawaguchi Takehiko, Nagasawa Tasuku, Miura Kenichiro, Katsuno Takayuki, Morikawa Takashi, Ishikawa Eiji, Ogura Masao, Matsumura Hideki, Kurayama Ryota, Matsumoto Shinsuke, Marui Yuhji, Hara Shigeo, Maruyama Shoichi, Narita Ichiei, Okada Hirokazu, Tsuruya Kazuhiko

Clin Exp Nephrol Vol. 25 ( 10 ) page： 1161 - 1161 2021.10

Urinary Metabolome Analyses of Patients with Acute Kidney Injury Using Capillary Electrophoresis-Mass Spectrometry Reviewed

Saito Rintaro, Hirayama Akiyoshi, Akiba Arisa, Kamei Yushi, Kato Yuyu, Ikeda Satsuki, Kwan Brian, Pu Minya, Natarajan Loki, Shinjo Hibiki, Akiyama Shin'ichi, Tomita Masaru, Soga Tomoyoshi, Maruyama Shoichi

Metabolites Vol. 11 ( 10 ) page： 671 2021.10

The Alteration of Neutrophil Nuclear Morphology: A Potential Predictor for Corticosteroid Response in IgA Nephropathy

Muto, R; Kato, S; Maruyama, S

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Vol. 32 ( 10 ) page： 821 - 821 2021.10

Eculizumab for Treatment of Recurrent Pregnancy-Triggered Atypical Hemolytic-Uremic Syndrome with a Mutation in Complement 3: A Case Report

Miyabe, Y; Nakai, A; Watanabe, K; Karasawa, K; Kato, N; Maruyama, S; Moriyama, T; Nitta, K

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Vol. 32 ( 10 ) page： 826 - 827 2021.10

A Case of TAFRO Syndrome with Two Consecutive Renal Biopsies Following the Pathological Course of the Kidney

Kato, N; Hasegawa, T; Muto, R; Tanaka, A; Sato, Y; Maeda, K; Furuhashi, K; Saito, S; Kosugi, T; Maruyama, S

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Vol. 32 ( 10 ) page： 823 - 824 2021.10

Demographic, clinical characteristics and treatment outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulonephritis in Japan: A retrospective analysis of data from the Japan Renal Biopsy Registry Reviewed

Nakagawa Naoki, Mizuno Masashi, Kato Sawako, Maruyama Shoichi, Sato Hiroshi, Nakaya Izaya, Sugiyama Hitoshi, Fujimoto Shouichi, Miura Kenichiro, Matsumura Chieko, Gotoh Yoshimitsu, Suzuki Hitoshi, Kuroki Aki, Yoshino Atsunori, Nakatani Shinya, Hiromura Keiju, Yamamoto Ryohei, Yokoyama Hitoshi, Narita Ichiei, Isaka Yoshitaka

PLoS One Vol. 16 ( 9 ) page： e0257397 2021.9

Focal segmental glomerulosclerosis histologic variants and renal outcomes based on nephrotic syndrome, immunosuppression and proteinuria remission. Reviewed

Kawaguchi T, Imasawa T, Kadomura M, Kitamura H, Maruyama S, Ozeki T, Katafuchi R, Oka K, Isaka Y, Yokoyama H, Sugiyama H, Sato H

Nephrol Dial Transplant Vol. 37 ( 9 ) page： 1679 - 1690 2021.9

Factors predicting decline in renal function and kidney volume growth in autosomal dominant polycystic kidney disease: a prospective cohort study (Japanese Polycystic Kidney Disease registry: J-PKD) Reviewed

Uchiyama Kiyotaka, Mochizuki Toshio, Shimada Yosuke, Nishio Saori, Kataoka Hiroshi, Mitobe Michihiro, Tsuchiya Ken, Hanaoka Kazushige, Ubara Yoshifumi, Suwabe Tatsuya, Sekine Akinari, Nutahara Kikuo, Tsuruya Kazuhiko, Ishimura Eiji, Nakatani Shinya, Sofue Tadashi, Tanaka Satoshi, Narita Ichiei, Maruyama Shoichi, Horie Shigeo, Muto Satoru

Clin Exp Nephrol Vol. 25 ( 9 ) page： 970 - 980 2021.9

Roles of glomerular endothelial hyaluronan in the development of proteinuria Reviewed Open Access

Asai, A; Hatayama, N; Kamiya, K; Yamauchi, M; Kinashi, H; Yamaguchi, M; Katsuno, T; Nobata, H; Watanabe, K; Wakatsuki, A; Aten, J; Maruyama, S; Ishimoto, T; Hirai, S; Naito, M; Ito, Y

Physiol Rep Vol. 9 ( 17 ) page： e15019 2021.9

Low-GDP, pH-neutral solutions preserve peritoneal endothelial glycocalyx during long-term peritoneal dialysis Reviewed

Sugiyama Naoya, Tawada Mitsuhiro, Sun Ting, Suzuki Yasuhiro, Kinashi Hiroshi, Yamaguchi Makoto, Katsuno Takayuki, Aten Jan, Vlahu Carmen A., van Kuppevelt Toin H., Takei Yoshifumi, Ishimoto Takuji, Maruyama Shoichi, Mizuno Masashi, Ito Yasuhiko

Clin Exp Nephrol Vol. 25 ( 9 ) page： 1035 - 1046 2021.9

All-cause and cardiovascular mortality in patients undergoing hemodialysis with aortic sclerosis and mild-to-moderate aortic stenosis: A cohort study Reviewed

Kurasawa Shimon, Hishida Manabu, Imaizumi Takahiro, Okazaki Masaki, Nishibori Nobuhiro, Kondo Toru, Kasuga Hirotake, Maruyama Shoichi

Atherosclerosis Vol. 331 page： 12 - 19 2021.8

Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP(+) regulatory T cells Reviewed

Satoh Kazuki, Kobayashi Yoichi, Fujimaki Kaori, Hayashi Shinko, Ishida Saori, Sugiyama Daisuke, Sato Takahiko, Lim Kyungtaek, Miyamoto Megumi, Kozuma Shiho, Kadokura Michinori, Wakita Kenichi, Hata Masato, Hirahara Kazuki, Amano Masato, Watanabe Ichiro, Okamoto Atsushi, Tuettenberg Andrea, Jonuleit Helmut, Tanemura Atsushi, Maruyama Shoichi, Agatsuma Toshinori, Wada Teiji, Nishikawa Hiroyoshi

Int Immunol Vol. 33 ( 8 ) page： 435 - 446 2021.8

Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity Reviewed

Kobayashi Azusa, Ito Ayaka, Shirakawa Ibuki, Tamura Atsushi, Tomono Susumu, Shindou Hideo, Hedde Per Niklas, Tanaka Miyako, Tsuboi Naotake, Ishimoto Takuji, Akashi-Takamura Sachiko, Maruyama Shoichi, Suganami Takayoshi

Front Immunol Vol. 12 page： 650856 2021.6

C1 inhibitor mitigates peritoneal injury in zymosan-induced peritonitis Reviewed

Ozeki Toshikazu, Mizuno Masashi, Iguchi Daiki, Kojima Hiroshi, Kim Hangsoo, Suzuki Yasuhiro, Kinashi Hiroshi, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko

American journal of physiology. Renal physiology Vol. 320 ( 6 ) page： F1123 - F1132 2021.6

Impact of serum magnesium and bone mineral density on systemic fractures in chronic hemodialysis patients Reviewed

Hori Mayuko, Yasuda Kaoru, Takahashi Hiroshi, Yamazaki Chikao, Morozumi Kunio, Maruyama Shoichi

PLoS One Vol. 16 ( 5 ) page： e0251912 2021.5

Relationship between mortality and use of sodium bicarbonate at the time of dialysis initiation: a prospective observational study Reviewed Open Access

Morooka, H; Yamamoto, J; Tanaka, A; Inaguma, D; Maruyama, S

BMC Nephrol Vol. 22 ( 1 ) page： 118 2021.4

Efficacy of favipiravir for an end stage renal disease patient on maintenance hemodialysis infected with novel coronavirus disease 2019 Reviewed Open Access

Koshi, E; Saito, S; Okazaki, M; Toyama, Y; Ishimoto, T; Kosugi, T; Hiraiwa, H; Jingushi, N; Yamamoto, T; Ozaki, M; Goto, Y; Numaguchi, A; Miyagawa, Y; Kato, I; Tetsuka, N; Yagi, T; Maruyama, S

CEN Case Rep Vol. 10 ( 1 ) page： 126 - 131 2021.2

Relationship between selection of dosage forms of vitamin D receptor activators and short-term survival of patients on hemodialysis Reviewed

Koshi-Ito Eri, Inaguma Daijo, Koide Shigehisa, Takahashi Kazuo, Hayashi Hiroki, Tsuboi Naotake, Hasegawa Midori, Maruyama Shoichi, Yuzawa Yukio

Ren Fail Vol. 43 ( 1 ) page： 1528 - 1538 2021.1

Development of entrustable professional activities for residents rotating nephrology department in a Japanese university hospital: a Delphi study Reviewed

Tanaka Akihito, Kondo Takeshi, Urushibara-Miyachi Yuka, Maruyama Shoichi, Nishigori Hiroshi

BMJ Open Vol. 11 ( 8 ) page： e047923 2021

A nationwide cross-sectional analysis of thrombotic microangiopathy in the Japan Renal Biopsy Registry (J-RBR) Reviewed

Katsuno T, Ito Y, Kagami S, Kitamura H, Maruyama S, Shimizu A, Sugiyama H, Sato H, Yokoyama H, Kashihara N

Clin Exp Nephrol Vol. 24 ( 9 ) page： 789 - 797 2020.9

Additional prognostic value of toe-brachial index beyond ankle-brachial index in hemodialysis patients Reviewed Open Access

Hishida, M; Imaizumi, T; Menez, S; Okazaki, M; Akiyama, S; Kasuga, H; Ishigami, J; Maruyama, S; Matsushita, K

BMC Nephrol Vol. 21 ( 1 ) page： 353 2020.8

Progress in Diagnosis and Treatment of Glomerulonephritis・Nephrotic Syndrome

Maruyama Shoichi

Nihon Naika Gakkai Zasshi Vol. 109 ( 5 ) page： 877 - 880 2020.5

Clinical Impact of Urinary CD11b and CD163 on the Renal Outcomes of Anti-neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis Reviewed

Yokoe Y, Tsuboi N, Imaizumi T, Kitagawa A, Karasawa M, Ozeki T, Endo N, Sawa Y, Kato S, Katsuno T, Maruyama S, Yamagata K, Usui J, Nagata M, Sada KE, Sugiyama H, Amano K, Arimura Y, Atsumi T, Yuzawa Y, Dobashi H, Takasaki Y, Harigai M, Hasegawa H, Makino H, Matsuo S

Nephrol Dial Transplant. Vol. 36 ( 8 ) page： 1452 - 1463 2020

Chronological change of renal pathological findings in the proliferative glomerulonephritis with monoclonal IgG deposits considered to have recurred early after kidney transplantation Reviewed

Katsuno Takayuki, Kato Masashi, Fujita Takashi, Tsuboi Naotake, Hattori Ryohei, Ito Yasuhiko, Maruyama Shoichi

CEN Case Rep Vol. 8 ( 3 ) page： 151 - 158 2019.8

Clinical impact of endocapillary proliferation with modified cutoff points in IgA nephropathy patients Reviewed Open Access

Kaihan Ahmad Baseer, Yasuda Yoshinari, Imaizumi Takahiro, Inagaki Koji, Ozeki Takaya, Hishida Manabu, Katsuno Takayuki, Tsuboi Naotake, Maruyama Shoichi

PLoS One Vol. 14 ( 3 ) page： e0214414 2019.3

Urinary levels of the leukocyte surface molecule CD11b associate with glomerular inflammation in lupus nephritis Reviewed Open Access

Kitagawa Akimitsu, Tsuboi Naotake, Yokoe Yuki, Katsuno Takayuki, Ikeuchi Hidekazu, Kajiyama Hiroshi, Endo Nobuhide, Sawa Yuriko, Suwa Junya, Sugiyama Yutaka, Hachiya Asaka, Mimura Toshihide, Hiromura Keiju, Maruyama Shoichi

Kidney Int Vol. 95 ( 3 ) page： 680 - 692 2019.3

Therapeutic efficacy of rituximab for the management of adult-onset steroid-dependent nephrotic syndrome: a retrospective study. Reviewed Open Access

Katsuno T, Masuda T, Saito S, Kato N, Ishimoto T, Kato S, Kosugi T, Tsuboi N, Kitamura H, Tsuzuki T, Ito Y, Maruyama S

Clin Exp Nephrol Vol. 23 ( 2 ) page： 207 - 214 2019.2

Safety and effectiveness of eculizumab for pediatric patients with atypical hemolytic-uremic syndrome in Japan: interim analysis of post-marketing surveillance. Reviewed Open Access

Ito S, Hidaka Y, Inoue N, Kaname S, Kato H, Matsumoto M, Miyakawa Y, Mizuno M, Okada H, Shimono A, Matsuda T, Maruyama S, Fujimura Y, Nangaku M, Kagami S

Clin Exp Nephrol Vol. 23 ( 1 ) page： 112 - 121 2019.1

Differences in peritoneal solute transport rates in peritoneal dialysis. Reviewed

Asano M, Ishii T, Hirayama A, Mizuno M, Suzuki Y, Sakata F, Akiyama SI, Maruyama S, Soga T, Kinashi H, Katsuno T, Ito Y

Clin Exp Nephrol Vol. 23 ( 1 ) page： 122 - 134 2019.1

Safety and effectiveness of eculizumab for adult patients with atypical hemolytic-uremic syndrome in Japan: interim analysis of post-marketing surveillance. Reviewed Open Access

Kato H, Miyakawa Y, Hidaka Y, Inoue N, Ito S, Kagami S, Kaname S, Matsumoto M, Mizuno M, Matsuda T, Shimono A, Maruyama S, Fujimura Y, Nangaku M, Okada H

Clin Exp Nephrol Vol. 23 ( 1 ) page： 65 - 75 2019.1

Anti-C5a complementary peptide mitigates zymosan-induced severe peritonitis with fibrotic encapsulation in rat pretreated with methylglyoxal. Reviewed Open Access

Iguchi D, Mizuno M, Suzuki Y, Sakata F, Maruyama S, Okada A, Okada H, Ito Y

American journal of physiology. Renal physiology Vol. 315 ( 6 ) page： F1732 - F1746 2018.12

Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis. Reviewed Open Access

Katsuno T, Ozaki T, Ozeki T, Hachiya A, Kim H, Kato N, Ishimoto T, Kato S, Kosugi T, Tsuboi N, Mizuno M, Ito Y, Maruyama S

Clin Exp Nephrol Vol. 22 ( 6 ) page： 1341 - 1350 2018.12

Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial. Reviewed Open Access

Kimura K, Hosoya T, Uchida S, Inaba M, Makino H, Maruyama S, Ito S, Yamamoto T, Tomino Y, Ohno I, Shibagaki Y, Iimuro S, Imai N, Kuwabara M, Hayakawa H, Ohtsu H, Ohashi Y, FEATHER Study Investigators.

American journal of kidney diseases : the official journal of the National Kidney Foundation Vol. 72 ( 6 ) page： 798 - 810 2018.12

Chronic Inflammatory Demyelinating Polyneuropathy With Concurrent Membranous Nephropathy: An Anti-paranode and Podocyte Protein Antibody Study and Literature Survey Reviewed Open Access

Hashimoto Yu, Ogata Hidenori, Yamasaki Ryo, Sasaguri Takakazu, Ko Senri, Yamashita Kenichiro, Xu Zhang, Matsushita Takuya, Tateishi Takahisa, Akiyama Shin'ichi, Maruyama Shoichi, Yamamoto Akifumi, Kira Jun-ichi

FRONTIERS IN NEUROLOGY Vol. 9 page： 997 2018.11

Thrombotic microangiopathy on kidney biopsy in a patient with TAFRO syndrome. Reviewed

Ozeki T, Tsuji M, Yamamoto J, Shigematsu C, Maruyama S

CEN case reports Vol. 7 ( 2 ) page： 243 - 247 2018.11

Renoprotective effects of topiroxostat for hyperuremic patients with overt diabetic nephropathy study (ETUDE Study): A prospective, randomized, multicenter clinical trial. Reviewed Open Access

Mizukoshi T, Kato S, Ando M, Sobajima H, Ohashi N, Naruse T, Saka Y, Shimizu H, Nagata T, Maruyama S

Nephrology (Carlton, Vic.) Vol. 23 ( 11 ) page： 1023 - 1030 2018.11

Smoking Is a Risk Factor for Relapse of Antimyeloperoxidase Antibodies-Associated Vasculitis. Reviewed

Yamaguchi M, Ando M, Katsuno T, Tsuboi N, Maruyama S

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases Vol. 24 ( 7 ) page： 361 - 367 2018.10

Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cell, but not Adipose Tissue-Derived Stem Cell, Ameliorated the Neonatal Hypoxic-Ischemic Brain Injury by Changing Cerebral Inflammatory State in Rat Reviewed Open Access

Sugiyama Yuichiro, Sato Yoshiaki, Kitase Yuma, Suzuki Toshihiko, Kondo Taiki, Mikrogeorgiou Alkisti, Horinouchi Asuka, Maruyama Shoichi, Shimoyama Yoshie, Tsuji Masahiro, Suzuki Satoshi, Yamamoto Tokunori, Hayakawa Masahiro

FRONTIERS IN NEUROLOGY Vol. 9 page： 757 2018.9

Clinical impact of endocapillary proliferation according to the Oxford classification among adults with Henoch- Schonlein purpura nephritis: a multicenter retrospective cohort study Reviewed Open Access

Inagaki Koji, Kaihan Ahmad Baseer, Hachiya Asaka, Ozeki Takaya, Ando Masahiko, Kato Sawako, Yasuda Yoshinari, Maruyama Shoichi

BMC NEPHROLOGY Vol. 19 ( 1 ) page： 208 2018.8

CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease Reviewed Open Access

Maeda Kayaho, Otomo Kotaro, Yoshida Nobuya, Abu-Asab Mones S., Ichinose Kunihiro, Nishino Tomoya, Kono Michihito, Ferretti Andrew, Bhargava Rhea, Maruyama Shoichi, Bickerton Sean, Fahmy Tarek M., Tsokos Maria G., Tsokos George C.

JOURNAL OF CLINICAL INVESTIGATION Vol. 128 ( 8 ) page： 3445 - 3459 2018.8

The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases. Reviewed Open Access

Mori Yoshiko, Masuda Tomohiro, Kosugi Tomoki, Yoshioka Tomoki, Hori Mayuko, Nagaya Hiroshi, Maeda Kayaho, Sato Yuka, Kojima Hiroshi, Kato Noritoshi, Ishimoto Takuji, Katsuno Takayuki, Yuzawa Yukio, Kadomatsu Kenji, Maruyama Shoichi

Clin Exp Nephrol Vol. 22 ( 4 ) page： 815 - 824 2018.8

Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice. Reviewed Open Access

Doke T, Ishimoto T, Hayasaki T, Ikeda S, Hasebe M, Hirayama A, Soga T, Kato N, Kosugi T, Tsuboi N, Lanaspa MA, Johnson RJ, Kadomatsu K, Maruyama S

Metabolism: clinical and experimental Vol. 85 page： 161 - 170 2018.8

Clinical features and pathogenesis of membranoproliferative glomerulonephritis: a nationwide analysis of the Japan renal biopsy registry from 2007 to 2015 Reviewed Open Access

Nakagawa Naoki, Hasebe Naoyuki, Hattori Motoshi, Nagata Michio, Yokoyama Hitoshi, Sato Hiroshi, Sugiyama Hitoshi, Shimizu Akira, Isaka Yoshitaka, Maruyama Shoichi, Narita Ichiei

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 22 ( 4 ) page： 797 - 807 2018.8

A consensus statement on health-care transition of patients with childhood-onset chronic kidney diseases: providing adequate medical care in adolescence and young adulthood Reviewed Open Access

Kubota Wataru, Honda Masataka, Okada Hirokazu, Hattori Motoshi, Iwano Masayuki, Akioka Yuko, Ashida Akira, Kawasaki Yukihiko, Kiyomoto Hideyasu, Sako Mayumi, Terada Yoshio, Hirano Daishi, Fujieda Mikiya, Fujimoto Shouichi, Masaki Takao, Ito Shuichi, Uemura Osamu, Gotoh Yoshimitsu, Komatsu Yasuhiro, Nishi Shinichi, Maru Mitsue, Narita Ichiei, Maruyama Shoichi

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 22 ( 4 ) page： 743 - 751 2018.8

Urinary protein and renal prognosis in idiopathic membranous nephropathy: a multicenter retrospective cohort study in Japan Reviewed Open Access

Yamaguchi Makoto, Ando Masahiko, Katsuno Takayuki, Tsuboi Naotake, Maruyama Shoichi

RENAL FAILURE Vol. 40 ( 1 ) page： 435 - 441 2018.7

Treatment patterns and steroid dose for adult minimal change disease relapses: A retrospective cohort study Reviewed Open Access

Ozeki Takaya, Ando Masahiko, Yamaguchi Makoto, Katsuno Takayuki, Kato Sawako, Yasuda Yoshinari, Tsuboi Naotake, Maruyama Shoichi

PLOS ONE Vol. 13 ( 6 ) page： e0199228 2018.6

Rationale and study design of a clinical trial to assess the effects of LDL apheresis on proteinuria in diabetic patients with severe proteinuria and dyslipidemia Reviewed

Wada Takashi, Muso Eri, Maruyama Shoichi, Hara Akinori, Furuichi Kengo, Yoshimura Kenichi, Miyazaki Mariko, Sato Eiichi, Abe Masanori, Shibagaki Yugo, Narita Ichiei, Yokoyama Hitoshi, Mori Noriko, Yuzawa Yukio, Matsubara Takeshi, Tsukamoto Tatsuo, Wada Jun, Ito Takafumi, Masutani Kosuke, Tsuruya Kazuhiko, Fujimoto Shoichi, Tsuda Akihiro, Suzuki Hitoshi, Kasuno Kenji, Terada Yoshio, Nakata Takeshi, Iino Noriaki, Kobayashi Shuzo

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 22 ( 3 ) page： 591 - 596 2018.6

Distinct characteristics and outcomes in elderly-onset IgA vasculitis (Henoch-Schonlein purpura) with nephritis: Nationwide cohort study of data from the Japan Renal Biopsy Registry (J-RBR) Reviewed Open Access

Komatsu Hiroyuki, Fujimoto Shouichi, Maruyama Shoichi, Mukoyama Masashi, Sugiyama Hitoshi, Tsuruya Kazuhiko, Sato Hiroshi, Soma Jun, Yano Junko, Itano Seiji, Nishino Tomoya, Sato Toshinobu, Narita Ichiei, Yokoyama Hitoshi

PLOS ONE Vol. 13 ( 5 ) page： e0196955 2018.5

Chondroitin sulfate protects vascular endothelial cells from toxicities of extracellular histones Reviewed

Nagano Fumihiko, Mizuno Tomohiro, Mizumoto Shuji, Yoshioka Kengo, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Yamada Shuhei, Nagamatsu Tadashi

EUROPEAN JOURNAL OF PHARMACOLOGY Vol. 826 page： 48 - 55 2018.5

Lifestyle intervention using Internet of Things (IoT) for the elderly: A study protocol for a randomized control trial (the BEST-LIFE study) Reviewed Open Access

Kato Sawako, Ando Masahiko, Kondo Takaaki, Yoshida Yasuko, Honda Hiroyuki, Maruyama Shoichi

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 2 ) page： 175 - 182 2018.5

Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS Reviewed

Shimizu Miho, Furuichi Kengo, Toyama Tadashi, Funamoto Tomoaki, Kitajima Shinji, Hara Akinori, Ogawa Daisuke, Koya Daisuke, Ikeda Kenzo, Koshino Yoshitaka, Kurokawa Yukie, Abe Hideharu, Mori Kiyoshi, Nakayama Masaaki, Konishi Yoshio, Samejima Ken-ichi, Matsui Masaru, Yamauchi Hiroyuki, Gohda Tomohito, Fukami Kei, Nagata Daisuke, Yamazaki Hidenori, Yuzawa Yukio, Suzuki Yoshiki, Fujimoto Shouichi, Maruyama Shoichi, Kato Sawako, Naito Takero, Yoshimura Kenichi, Yokoyama Hitoshi, Wada Takashi

Clin Exp Nephrol Vol. 22 ( 2 ) page： 377 - 387 2018.4

Unfavorable effects of history of volume overload and late referral to a nephrologist on mortality in patients initiating dialysis: a multicenter prospective cohort study in Japan Reviewed Open Access

Okazaki Masaki, Inaguma Daijo, Imaizumi Takahiro, Kada Akiko, Yaomura Takaaki, Tsuboi Naotake, Maruyama Shoichi

BMC NEPHROLOGY Vol. 19 ( 1 ) page： 65 2018.3

TGF-beta 1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis Reviewed

Kariya Tetsuyoshi, Nishimura Hayato, Mizuno Masashi, Suzuki Yasuhiro, Matsukawa Yoshihisa, Sakata Fumiko, Maruyama Shoichi, Takei Yoshifumi, Ito Yasuhiko

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY Vol. 314 ( 2 ) page： F167 - F180 2018.2

Rationale and design of oBservational clinical Research In chronic kidney disease patients with renal anemia: renal proGnosis in patients with Hyporesponsive anemia To Erythropoiesis-stimulating agents, darbepoetiN alfa (BRIGHTEN Trial) Reviewed Open Access

Kato Hideki, Nangaku Masaomi, Hirakata Hideki, Wada Takashi, Hayashi Terumasa, Sato Hiroshi, Yamazaki Yasushi, Masaki Takao, Kagimura Tatsuo, Yamamoto Hiroyasu, Hase Hiroki, Kamouchi Masahiro, Imai Enyu, Mizuno Kyoichi, Iwasaki Manabu, Akizawa Tadao, Tsubakihara Yoshiharu, Maruyama Shoichi, Narita Ichiei

Clin Exp Nephrol Vol. 22 ( 1 ) page： 78 - 84 2018.2

Kato, H; Nangaku, M; Hirakata, H; Wada, T; Hayashi, T; Sato, H; Yamazaki, Y; Masaki, T; Kagimura, T; Yamamoto, H; Hase, H; Kamouchi, M; Imai, E; Mizuno, K; Iwasaki, M; Akizawa, T; Tsubakihara, Y; Maruyama, S; Narita, I

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 22 ( 1 ) page： 85 - 86 2018.2

Effect of dietary energy and polymorphisms in BRAP and GHRL on obesity and metabolic traits. Reviewed

Imaizumi Takahiro, Ando Masahiko, Nakatochi Masahiro, Yasuda Yoshinari, Honda Hiroyuki, Kuwatsuka Yachiyo, Kato Sawako, Kondo Takaaki, Iwata Masamitsu, Nakashima Toru, Yasui Hiroshi, Takamatsu Hideki, Okajima Hiroshi, Yoshida Yasuko, Maruyama Shoichi

Obes Res Clin Pract Vol. 12 ( 1 ) page： 39 - 48 2018.1

Urinary and circulating levels of the anti-angiogenic isoform of vascular endothelial growth factor-A in patients with chronic kidney disease Reviewed

Kikuchi Ryosuke, Yasuda Yoshinari, Nakatochi Masahiro, Shibata Yohei, Hara Toshiaki, Suzuki Atsuo, Imaizumi Takahiro, Suzuki Susumu, Ishii Hideki, Takeshita Kyosuke, Matsushita Tadashi, Maruyama Shoichi, Murohara Toyoaki

Clin Chim Acta Vol. 475 page： 102 - 108 2017.12

The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients Reviewed

Kaihan Ahmad Baseer, Yasuda Yoshinari, Katsuno Takayuki, Kato Sawako, Imaizumi Takahiro, Ozeki Takaya, Hishida Manabu, Nagata Takanobu, Ando Masahiko, Tsuboi Naotake, Maruyama Shoichi

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 21 ( 6 ) page： 986 - 994 2017.12

Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome Reviewed Open Access

Saito Takao, Iwano Masayuki, Matsumoto Koichi, Mitarai Tetsuya, Yokoyama Hitoshi, Yorioka Noriaki, Nishi Shinichi, Yoshimura Ashio, Sato Hiroshi, Ogahara Satoru, Sasatomi Yoshie, Kataoka Yasufumi, Ueda Shiro, Koyama Akio, Maruyama Shoichi, Nangaku Masaomi, Imai Enyu, Matsuo Seiichi, Tomino Yasuhiko

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 21 ( 6 ) page： 961 - 970 2017.12

Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission Reviewed Open Access

Inagaki Koji, Yasuda Yoshinari, Ando Masahiko, Kaihan Ahmad Baseer, Hachiya Asaka, Ozeki Takaya, Hishida Manabu, Imaizumi Takahiro, Katsuno Takayuki, Kato Sawako, Tsuboi Naotake, Maruyama Shoichi

PLOS ONE Vol. 12 ( 11 ) page： e0187607 2017.11

Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers Reviewed Open Access

Kubo Yoko, Imaizumi Takahiro, Ando Masahiko, Nakatochi Masahiro, Yasuda Yoshinari, Honda Hiroyuki, Kuwatsuka Yachiyo, Kato Sawako, Kikuchi Kyoko, Kondo Takaaki, Iwata Masamitsu, Nakashima Toru, Yasui Hiroshi, Takamatsu Hideki, Okajima Hiroshi, Yoshida Yasuko, Maruyama Shoichi

PLOS ONE Vol. 12 ( 10 ) page： e0185476 2017.10

Efficacy of urinary midkine as a biomarker in patients with acute kidney injury Reviewed Open Access

Hayashi Hiroki, Sato Waichi, Kosugi Tomoki, Nishimura Kunihiro, Sugiyama Daisuke, Asano Naoko, Ikematsu Shinya, Komori Kimihiro, Nishiwaki Kimitoshi, Kadomatsu Kenji, Matsuo Seiichi, Maruyama Shoichi, Yuzawa Yukio

Clin Exp Nephrol Vol. 21 ( 4 ) page： 597 - 607 2017.8

Randomized controlled trial for assessment of Internet of Things system to guide intensive glucose control in diabetes outpatients: Nagoya Health Navigator Study protocol Reviewed Open Access

Onoue Takeshi, Goto Motomitsu, Kobayashi Tomoko, Tominaga Takashi, Ando Masahiko, Honda Hiroyuki, Yoshida Yasuko, Tosaki Takahiro, Yokoi Hisashi, Kato Sawako, Maruyama Shoichi, Arima Hiroshi

Nagoya J Med Sci Vol. 79 ( 3 ) page： 323 - 329 2017.8

Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice Reviewed Open Access

Yashima Akihito, Mizuno Masashi, Yuzawa Yukio, Shimada Koki, Suzuki Norihiko, Tawada Hideo, Sato Waichi, Tsuboi Naotake, Maruyama Shoichi, Ito Yasuhiko, Matsuo Seiichi, Ohno Tamio

Clin Exp Nephrol Vol. 21 ( 4 ) page： 589 - 596 2017.8

Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice Reviewed Open Access

Tomita Takako, Arai Satoko, Kitada Kento, Mizuno Masashi, Suzuki Yasuhiro, Sakata Fumiko, Nakano Daisuke, Hiramoto Emiri, Takei Yoshifumi, Maruyama Shoichi, Nishiyama Akira, Matsuo Seiichi, Miyazaki Toru, Ito Yasuhiko

Sci Rep Vol. 7 ( 1 ) page： 6450 2017.7

Long-term renal survival of gamma 3-heavy chain deposition disease: a case report Reviewed Open Access

Katsuno Takayuki, Mizuno Shige, Mabuchi Masatsuna, Tsuboi Naotake, Komatsuda Atsushi, Maruyama Shoichi

BMC NEPHROLOGY Vol. 18 ( 1 ) page： 239 2017.7

Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers Reviewed

Imaizumi Takahiro, Ando Masahiko, Nakatochi Masahiro, Maruyama Shoichi, Yasuda Yoshinari, Honda Hiroyuki, Kuwatsuka Yachiyo, Kato Sawako, Kondo Takaaki, Iwata Masamitsu, Nakashima Toru, Yasui Hiroshi, Takamatsu Hideki, Okajima Hiroshi, Yoshida Yasuko, Matsuo Seiichi

Clin Exp Nephrol Vol. 21 ( 3 ) page： 457 - 464 2017.6

Sodium chloride promotes tissue inflammation via osmotic stimuli in subtotal-nephrectomized mice Reviewed Open Access

Sakata Fumiko, Ito Yasuhiko, Mizuno Masashi, Sawai Akiho, Suzuki Yasuhiro, Tomita Takako, Tawada Mitsuhiro, Tanaka Akio, Hirayama Akiyoshi, Sagara Akihiro, Wada Takashi, Maruyama Shoichi, Soga Tomoyoshi, Matsuo Seiichi, Imai Enyu, Takei Yoshifumi

LABORATORY INVESTIGATION Vol. 97 ( 4 ) page： 432 - 446 2017.4

Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis Reviewed Open Access

Masuda Tomohiro, Maeda Kayaho, Sato Waichi, Kosugi Tomoki, Sato Yuka, Kojima Hiroshi, Kato Noritoshi, Ishimoto Takuji, Tsuboi Naotake, Uchimura Kenji, Yuzawa Yukio, Maruyama Shoichi, Kadomatsu Kenji

Am J Pathol Vol. 187 ( 4 ) page： 740 - 751 2017.4

Postpartum atypical hemolytic uremic syndrome with complement factor H mutation complicated by reversible cerebrovascular constriction syndrome successfully treated with eculizumab Reviewed

Yamaguchi Makoto, Hori Mayuko, Hiroshi Nagaya, Maruyama Shoichi

Thromb Res Vol. 151 page： 79 - 81 2017.3

Complement component 5 promotes lethal thrombosis Reviewed Open Access

Mizuno Tomohiro, Yoshioka Kengo, Mizuno Masashi, Shimizu Mie, Nagano Fumihiko, Okuda Tomoyuki, Tsuboi Naotake, Maruyama Shoichi, Nagamatsu Tadashi, Imai Masaki

SCIENTIFIC REPORTS Vol. 7 page： 42714 2017.2

High Levels of Soluble C5b-9 Complex in Dialysis Fluid May Predict Poor Prognosis in Peritonitis in Peritoneal Dialysis Patients Reviewed Open Access

Mizuno Masashi, Suzuki Yasuhiro, Higashide Keiko, Sei Yumi, Iguchi Daiki, Sakata Fumiko, Horie Masanobu, Maruyama Shoichi, Matsuo Seiichi, Morgan B. Paul, Ito Yasuhiko

PLOS ONE Vol. 12 ( 1 ) page： e0169111 2017.1

The Type of Vascular Access and the Incidence of Mortality in Japanese Dialysis Patients Reviewed

Ozeki Toshikazu, Shimizu Hideaki, Fujita Yoshiro, Inaguma Daijo, Maruyama Shoichi, Ohyama Yukako, Minatoguchi Shun, Murai Yukari, Terashita Maho, Tagaya Tomoki

Internal Medicine Vol. 56 ( 5 ) page： 481 - 485 2017

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

Objective The National Kidney Foundation (NKF) Kidney Disease Outcome Quality Initiative (KDOQI) guidelines have recommended the use of arteriovenous fistula (AVF) at the initiation of dialysis. However, there are significant differences in the dialysis environments of Japan and the United States, and there are few people who receive hemodialysis via a central venous catheter (CVC) in Japan. The aim of the present study was to examine the association between the type of vascular access at the initiation of dialysis and the incidence of mortality in Japan. Methods This study was a prospective, multicenter, cohort study. The data was collected by the Aichi Cohort study of Prognosis in Patients newly initiated into dialysis (AICOPP) in which 18 Japanese tertiary care centers participated. The present study enrolled 1,524 patients who were newly introduced to dialysis (the patients started maintenance dialysis between October 2011 and September 2013). After excluding 183 patients with missing data, 1,341 patients were enrolled. The Cox proportional hazards model was used to evaluate mortality based on the type of vascular access. The types of vascular access were divided into four categories: AVF, arteriovenous graft (AVG), CVC changed to AVF during the course (CAVF), CVC changed to AVG during the course (CAVG). Results A multivariate analysis revealed that AVG, CAVF and CAVG were associated with a higher risk of mortality in comparison to AVF [hazard ratio (HR), 1.60; p=0.048; HR, 2.26; p=0.003; and HR, 2.45; p=0.001, respectively]. Conclusion The research proved that the survival rate among patients in whom hemodialysis was initiated with AVF was significantly higher than that in patients in whom hemodialysis was initiated with AVG or CVC.

DOI： 10.2169/internalmedicine.56.7563

Web of Science

PubMed

CiNii Research

Single-dose Rituximab Therapy for Refractory Idiopathic Membranous Nephropathy: A Single-center Experience Reviewed

Katsuno Takayuki, Ozaki Takenori, Kim Hangsoo, Kato Noritoshi, Suzuki Yasuhiro, Akiyama Shinichi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Ito Yasuhiko, Maruyama Shoichi

Intern Med Vol. 56 ( 13 ) page： 1679 - 1686 2017

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Society of Internal Medicine

To date, a recognized treatment for refractory membranous nephropathy (MN) has not been established. Recently, several reports have indicated the efficacy of rituximab as a novel treatment option. However, only a few published accounts exist of rituximab therapy for idiopathic MN (IMN) in the Asian population. We present the cases of three IMN patients who were treated with single-dose rituximab after they showed no response to conventional therapies, including corticosteroids, cyclosporine, cyclophosphamide, mizoribine, and mycophenolate mofetil. Although one case showed no response, a complete or incomplete remission was achieved in the other two cases. Rituximab may therefore be a beneficial treatment option for IMN.

DOI： 10.2169/internalmedicine.56.7908

Web of Science

PubMed

CiNii Research

Kidney biopsy guidebook 2020 in Japan Reviewed

Clin Exp Nephrol Vol. 25 ( 4 ) page： 325 - 364 2021.4

Importance of lymph node immune responses in MSI-H/dMMR colorectal cancer. Reviewed

Inamori K, Togashi Y, Fukuoka S, Akagi K, Ogasawara K, Irie T, Motooka D, Kobayashi Y, Sugiyama D, Kojima M, Shiiya N, Nakamura S, Maruyama S, Suzuki Y, Ito M, Nishikawa H

JCI Insight Vol. 6 ( 9 ) page： e137365 2021.3

Vascular endothelial growth factor (VEGF)-A and VEGF-A(165)b are associated with time to remission of granulomatosis with polyangiitis in a nationwide Japanese prospective cohort study Reviewed

Kikuchi Ryosuke, Tsuboi Naotake, Sada Ken-Ei, Nakatochi Masahiro, Yokoe Yuki, Suzuki Atsuo, Maruyama Shoichi, Murohara Toyoaki, Matsushita Tadashi, Amano Koichi, Atsumi Tatsuya, Takasaki Yoshinari, Ito Satoshi, Hasegawa Hitoshi, Dobashi Hiroaki, Ito Takafumi, Makino Hirofumi, Matsuo Seiichi

Ann Clin Bioche Vol. 58 ( 2 ) page： 86 - 94 2021.3

Refractory Hypotension Caused by Selenium Deficiency in a Patient on Peritoneal Dialysis. Reviewed

Ryuge A, Kim H, Suzuki Y, Okazaki M, Kojima H, Saito S, Kato N, Ishimoto T, Kosugi T, Maruyama S, Mizuno M

Intern Med Vol. 60 ( 15 ) page： 2461 - 2464 2021.2

Initial responsiveness to darbepoetin alfa and its contributing factors in non-dialysis chronic kidney disease patients in Japan Reviewed

Hayashi Terumasa, Kato Hideki, Tanabe Kenichiro, Nangaku Masaomi, Hirakata Hideki, Wada Takashi, Sato Hiroshi, Yamazaki Yasushi, Masaki Takao, Kagimura Tatsuo, Yamamoto Hiroyasu, Hase Hiroki, Kamouchi Masahiro, Imai Enyu, Mizuno Kyoichi, Iwasaki Manabu, Akizawa Tadao, Tsubakihara Yoshiharu, Maruyama Shoichi, Narita Ichiei

Clin Exp Nephrol Vol. 25 ( 2 ) page： 110 - 119 2021.2

Glucocorticoid treatment is associated with ICU-acquired hypernatremia: a nested case-control study Reviewed

Imaizumi Takahiro, Nakatochi Masahiro, Fujita Yoshiro, Yamamoto Rie, Watanabe Kennshi, Maekawa Michitaka, Yamawaka Taishi, Katsuno Takayuki, Maruyama Shoichi

Clin Exp Nephrol Vol. 25 ( 2 ) page： 131 - 139 2021.2

Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease Reviewed

Ozeki Takaya, Maruyama Shoichi, Imasawa Toshiyuki, Kawaguchi Takehiko, Kitamura Hiroshi, Kadomura Moritoshi, Katafuchi Ritsuko, Oka Kazumasa, Yokoyama Hitoshi, Sugiyama Hitoshi, Sato Hiroshi

Sci Rep Vol. 11 ( 1 ) page： 2602 2021.1

Cardiovascular disease history and β-blocker prescription patterns among Japanese and American patients with CKD: a cross-sectional study of the CRIC and CKD-JAC studies. Reviewed

Imaizumi Takahiro, Hamano Takayuki, Fujii Naohiko, Huang Jing, Xie Dawei, Ricardo Ana C., He Jiang, Soliman Elsayed Z., Kusek John W., Nessel Lisa, Yang Wei, Maruyama Shoichi, Fukagawa Masafumi, Feldman Harold I.

Hypertens Res Vol. 44 ( 6 ) page： 700 - 710 2021.1

The ISN/RPS 2016 classification predicts renal prognosis in patients with first-onset class III/IV lupus nephritis Reviewed

Hachiya Asaka, Karasawa Munetoshi, Imaizumi Takahiro, Kato Noritoshi, Katsuno Takayuki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Maruyama Shoichi

Sci Rep Vol. 11 ( 1 ) page： 1525 2021.1

Nephrotic syndrome with focal segmental glomerular lesions unclassified by Columbia classification; Pathology and clinical implication Reviewed

Ozeki Takaya, Nagata Michio, Katsuno Takayuki, Inagaki Koji, Goto Kazunori, Kato Sawako, Yasuda Yoshinari, Tsuboi Naotake, Maruyama Shoichi

PLoS One Vol. 16 ( 1 ) page： e0244677 2021.1

Effects of LDL apheresis on proteinuria in patients with diabetes mellitus, severe proteinuria, and dyslipidemia Reviewed

Wada Takashi, Hara Akinori, Muso Eri, Maruyama Shoichi, Kato Sawako, Furuichi Kengo, Yoshimura Kenichi, Toyama Tadashi, Sakai Norihiko, Suzuki Hiroyuki, Tsukamoto Tatsuo, Miyazaki Mariko, Sato Eiichi, Abe Masanori, Shibagaki Yugo, Narita Ichiei, Goto Shin, Sakamaki Yuichi, Yokoyama Hitoshi, Mori Noriko, Yuzawa Yukio, Hasegawa Midori, Matsubara Takeshi, Wada Jun, Tanabe Katsuyuki, Masutani Kosuke, Abe Yasuhiro, Tsuruya Kazuhiko, Fujimoto Shouichi, Iwatsubo Shuji, Tsuda Akihiro, Suzuki Hitoshi, Kasuno Kenji, Terada Yoshio, Nakata Takeshi, Iino Noriaki, Sofue Tadashi, Miyata Hitomi, Nakano Toshiaki, Ohtake Takayasu, Kobayashi Shuzo

Clin Exp Nephrol Vol. 25 ( 1 ) page： 1 - 8 2021.1

Impact of the number of steroid pulses in tonsillectomy combined with steroid pulse therapy: a nationwide retrospective study in Japan Reviewed

Moriyama Takahito, Kataoka Hiroshi, Nitta Kosaku, Hirano Keita, Matsuzaki Keiichi, Yasuda Takashi, Yasuda Yoshinari, Koike Kentaro, Maruyama Shoichi, Yokoo Takashi, Matsuo Seiichi, Kawamura Tetsuya, Suzuki Yusuke

Clin Exp Nephrol Vol. 25 ( 1 ) page： 19 - 27 2021.1

Oral Antibiotics are Effective for Preventing Colonoscopy-associated Peritonitis as a Preemptive Therapy in Patients on Peritoneal Dialysis Reviewed

Suzuki Yasuhiro, Mizuno Masashi, Kojima Hiroshi, Sato Yuka, Kim Hangsoo, Kinashi Hiroshi, Katsuno Takayuki, Ishimoto Takuji, Maruyama Shoichi, Ito Yasuhiko

Intern Med Vol. 60 ( 3 ) page： 353 - 356 2021

Acquired Fanconi Syndrome in a Patient with Nontyphoidal Salmonella Bacteremia Reviewed

Ryuge Akihiro, Saito Shoji, Morioka Hiroshi, Hachiya Asaka, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi

Intern Med Vol. 60 ( 5 ) page： 761 - 764 2021

Validity of "One-size-fits-all" Approaches for the National Health Screening and Education Program: A Large-Scale Cohort Study of Corporate Insurance Beneficiaries. Reviewed

Kikuchi K, Imaizumi T, Ando M, Kato S, Kondo T, Honda H, Yoshida Y, Maruyama S

Intern Med Vol. 60 ( 11 ) page： 1681 - 1689 2020.12

A Prospective, Randomized Clinical Trial of Etelcalcetide in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism (the DUET Trial) Reviewed

Itano Yuya, Kato Sawako, Tsuboi Masato, Kasuga Hirotake, Tsuruta Yoshinari, Sato Fumihiko, Hishida Manabu, Ishimoto Takuji, Kosugi Tomoki, Ando Masahiko, Kuwatsuka Yachiyo, Maruyama Shoichi

Kidney Int Rep Vol. 5 ( 12 ) page： 2168 - 2177 2020.12

High urinary glucose is associated with improved renal prognosis in patients with diabetes mellitus Reviewed

Itano Yuya, Sobajima Hiroshi, Ohashi Norimi, Shibata Taiga, Fujiya Atsushi, Nagata Takanobu, Ando Masahiko, Imaizumi Takahiro, Kubo Yoko, Ozeki Takaya, Katsuno Takayuki, Kato Sawako, Yasuda Yoshinari, Maruyama Shoichi

J Diabetes Investig Vol. 12 ( 6 ) page： 998 - 1006 2020.11

Long-term changes in renal function after treatment initiation and the importance of early diagnosis in maintaining renal function among IgG4-related tubulointerstitial nephritis patients in Japan Reviewed

Arai Haruna, Ogata Soshiro, Ozeki Takaya, Takahashi Kazuo, Tsuboi Naotake, Maruyama Shoichi, Inaguma Daijo, Hasegawa Midori, Yuzawa Yukio, Hayashi Hiroki

Arthritis Res Ther Vol. 22 ( 1 ) page： 261 2020.11

C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury. Reviewed

Tanaka M, Saka-Tanaka M, Ochi K, Fujieda K, Sugiura Y, Miyamoto T, Kohda H, Ito A, Miyazawa T, Matsumoto A, Aoe S, Miyamoto Y, Tsuboi N, Maruyama S, Suematsu M, Yamasaki S, Ogawa Y, Suganami T

J Exp Med Vol. 217 ( 11 ) page： e20192230 2020.11

The revised version 2018 of the nationwide web-based registry system for kidney diseases in Japan: Japan Renal Biopsy Registry and Japan Kidney Disease Registry. Reviewed

Ozeki T, Maruyama S, Nagata M, Shimizu A, Sugiyama H, Sato H, Yokoyama H, Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology.

Clin Exp Nephrol Vol. 24 ( 11 ) page： 1058 - 1068 2020.11

Prognostic Impact of Parameters of Metabolic Acidosis in Critically Ill Children with Acute Kidney Injury: A Retrospective Observational Analysis Using the PIC Database Reviewed

Morooka Hikaru, Kasugai Daisuke, Tanaka Akihito, Ozaki Masayuki, Numaguchi Atsushi, Maruyama Shoichi

Diagnostics (Basel) Vol. 10 ( 11 ) page： 937 2020.11

Prevalences of hyperuricemia and electrolyte abnormalities in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB) Reviewed

Sofue Tadashi, Nakagawa Naoki, Kanda Eiichiro, Nagasu Hajime, Matsushita Kunihiro, Nangaku Masaomi, Maruyama Shoichi, Wada Takashi, Terada Yoshio, Yamagata Kunihiro, Narita Ichiei, Yanagita Motoko, Sugiyama Hitoshi, Shigematsu Takashi, Ito Takafumi, Tamura Kouichi, Isaka Yoshitaka, Okada Hirokazu, Tsuruya Kazuhiko, Yokoyama Hitoshi, Nakashima Naoki, Kataoka Hiromi, Ohe Kazuhiko, Okada Mihoko, Kashihara Naoki

PLoS One Vol. 15 ( 10 ) page： e0240402 2020.10

Better remission rates in elderly Japanese patients with primary membranous nephropathy in nationwide real-world practice: The Japan Nephrotic Syndrome Cohort Study (JNSCS). Reviewed

Yokoyama H, Yamamoto R, Imai E, Maruyama S, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Fukami K, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Terada Y, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Furuichi K, Fujimoto K, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y

Clin Exp Nephrol Vol. 24 ( 10 ) page： 893 - 909 2020.10

Temporal change in life and renal prognosis of rapidly progressive glomerulonephritis in Japan via nationwide questionnaire survey (vol 23, pg 573, 2019) Reviewed

Yamagata Kunihiro, Usui Joichi, Sugiyama Hitoshi, Maruyama Shoichi, Narita Ichiei

Clin Exp Nephrol Vol. 24 ( 10 ) page： 976 - 977 2020.10

Comprehensive Dipeptide Profiling and Quantitation by Capillary Electrophoresis and Liquid Chromatography Coupled with Tandem Mass Spectrometry Reviewed

Ozawa Hitoshi, Hirayama Akiyoshi, Ishikawa Takamasa, Kudo Ryuhei, Maruyama Midori, Shoji Futaba, Doke Tomohito, Ishimoto Takuji, Maruyama Shoichi, Soga Tomoyoshi, Tomita Masaru

Anal Chem Vol. 92 ( 14 ) page： 9799 - 9806 2020.7

Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB). Reviewed

Sofue T, Nakagawa N, Kanda E, Nagasu H, Matsushita K, Nangaku M, Maruyama S, Wada T, Terada Y, Yamagata K, Narita I, Yanagita M, Sugiyama H, Shigematsu T, Ito T, Tamura K, Isaka Y, Okada H, Tsuruya K, Yokoyama H, Nakashima N, Kataoka H, Ohe K, Okada M, Kashihara N

PLoS One Vol. 15 ( 7 ) page： e0236132 2020.7

Impact of old age on the association between in-center extended-hours hemodialysis and mortality in patients on incident hemodialysis Reviewed

Okazaki Masaki, Inaguma Daijo, Imaizumi Takahiro, Hishida Manabu, Kurasawa Shimon, Kubo Yoko, Kato Sawako, Yasuda Yoshinari, Katsuno Takayuki, Kaneda Fumika, Maruyama Shoichi

PLoS One Vol. 15 ( 7 ) page： e0235900 2020.7

Complement profile in microscopic polyangiitis and granulomatosis with polyangiitis: analysis using sera from a nationwide prospective cohort study Reviewed

Fukui S., Ichinose K., Sada K-E, Miyamoto J., Harigai M., Amano K., Atsumi T., Takasaki Y., Dobashi H., Arimura Y., Hasegawa H., Yuzawa Y., Yamagata K., Tsuboi N., Maruyama S., Matsuo S., Makino H., Maeda T., Kawakami A.

Scand J Rheumatol Vol. 49 ( 4 ) page： 301 - 311 2020.7

Incidence of remission and relapse of proteinuria, end-stage kidney disease, mortality, and major outcomes in primary nephrotic syndrome: the Japan Nephrotic Syndrome Cohort Study (JNSCS). Reviewed

Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Terada Y, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y

Clin Exp Nephrol Vol. 24 ( 6 ) page： 526 - 540 2020.6

Darbepoetin Alfa in Patients with Advanced CKD without Diabetes: Randomized, Controlled Trial. Reviewed

Hayashi T, Maruyama S, Nangaku M, Narita I, Hirakata H, Tanabe K, Morita S, Tsubakihara Y, Imai E, Akizawa T, PREDICT Investigators.

Clin J Am Soc Nephrol Vol. 15 ( 5 ) page： 608 - 615 2020.5

A nationwide survey on clinical practice patterns and bleeding complications of percutaneous native kidney biopsy in Japan. Reviewed

Kawaguchi T, Nagasawsa T, Tsuruya K, Miura K, Katsuno T, Morikawa T, Ishikawa E, Ogura M, Matsumura H, Kurayama R, Matsumoto S, Marui Y, Hara S, Maruyama S, Narita I, Okada H, Ubara Y, Committee of Practical Guide for Kidney Biopsy 2019.

Clin Exp Nephrol Vol. 24 ( 5 ) page： 389 - 401 2020.5

J-CKD-DB: a nationwide multicentre electronic health record-based chronic kidney disease database in Japan. Reviewed

Nakagawa N, Sofue T, Kanda E, Nagasu H, Matsushita K, Nangaku M, Maruyama S, Wada T, Terada Y, Yamagata K, Narita I, Yanagita M, Sugiyama H, Shigematsu T, Ito T, Tamura K, Isaka Y, Okada H, Tsuruya K, Yokoyama H, Nakashima N, Kataoka H, Ohe K, Okada M, Kashihara N

Sci Rep Vol. 10 ( 1 ) page： 7351 2020.4

Inter-leg systolic blood pressure difference predicts cardiovascular events and mortality in incident hemodialysis patients Reviewed

Kato Sawako, Lindholm Bengt, Qureshi Abdul Rashid, Mukai Hideyuki, Yuzawa Yukio, Maruyama Shoichi

Int J Artif Organs Vol. 43 ( 4 ) page： 217 - 224 2020.4

Survival Benefit of Maintained or Increased Body Mass Index in Patients Undergoing Extended-Hours Hemodialysis Without Dietary Restrictions Reviewed

Hishida Manabu, Imaizumi Takahiro, Nishiyama Toshiro, Okazaki Masaki, Kaihan Ahmad Baseer, Kato Sawako, Kubo Yoko, Ando Masahiko, Kaneda Hiroshi, Maruyama Shoichi

J Ren Nutr Vol. 30 ( 2 ) page： 154 - 162 2020.3

Pharmacological monitoring of antiepileptic drugs in epilepsy patients on haemodialysis Reviewed

Araki Kunihiko, Nakamura Tomohiko, Takeuchi Yuko, Morozumi Saori, Horie Katsunori, Kobayashi Yasushi, Kawakami Osamu, Sobue Fumio, Ueda Takuya, Hamada Kensuke, Ando Tetsuo, Inoue Yushi, Yasui Keizo, Morozumi Kunio, Maruyama Shoichi, Katsuno Masahisa

Epileptic Disord Vol. 22 ( 1 ) page： 90 - 102 2020.2

Effectiveness of Lifestyle Intervention Using the Internet of Things System for Individuals with Early Type 2 Diabetes Mellitus Reviewed

Kato Sawako, Ando Masahiko, Honda Hiroyuki, Yoshida Yasuko, Imaizumi Takahiro, Yamamoto Naoki, Maruyama Shoichi

Intern Med Vol. 59 ( 1 ) page： 45 - 53 2020

Ectopic Relapse of Anti-neutrophil Cytoplasmic Antibody-associated Pituitary Vasculitis with No Elevation of Anti-neutrophil Cytoplasmic Antibodies after Renal Remission. Reviewed

Muto R, Inagaki K, Sato N, Sameshima T, Nagakura Y, Baba S, Kato N, Maruyama S, Akahori T

Intern Med Vol. 59 ( 24 ) page： 3187 - 3193 2020

Successful Introduction of Peritoneal Dialysis in an End-stage Renal Failure Patient with Idiopathic Aplastic Anemia Reviewed

Suzuki Yasuhiro, Mizuno Masashi, Sakata Fumiko, Kojima Hiroshi, Sato Yuka, Kishimoto Mayuko, Suzuki Nobuaki, Kinashi Hiroshi, Saito Shoji, Katsuno Takayuki, Kosugi Tomoki, Maruyama Shoichi, Murata Makoto, Kiyoi Hitoshi, Ito Yasuhiko

Intern Med Vol. 59 ( 5 ) page： 683 - 687 2020

Peripheral artery disease at the time of dialysis initiation and mortality: a prospective observational multicenter study Reviewed

Morooka Hikaru, Tanaka Akihito, Inaguma Daijo, Maruyama Shoichi

BMJ Open Vol. 10 ( 12 ) page： e042315 2020

Lower levels of proteinuria are associated with elevated mortality in incident dialysis patients Reviewed

Hishida Manabu, Shafi Tariq, Appel Lawrence J., Maruyama Shoichi, Inaguma Daijo, Matsushita Kunihiro

PLoS One Vol. 14 ( 12 ) page： e0226866 2019.12

Excessive salt intake increases peritoneal solute transport rate via local tonicity-responsive enhancer binding protein in subtotal nephrectomized mice Reviewed

Sun Ting, Sakata Fumiko, Ishii Takako, Tawada Mitsuhiro, Suzuki Yasuhiro, Kinashi Hiroshi, Katsuno Takayuki, Takei Yoshifumi, Maruyama Shoichi, Mizuno Masashi, Ito Yasuhiko

Nephrol Dial Transplant Vol. 34 ( 12 ) page： 2031 - 2042 2019.12

Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure Reviewed

Sato Yuka, Roncal-Jimenez Carlos A., Andres-Hernando Ana, Jensen Thomas, Tolan Dean R., Sanchez-Lozada Laura G., Newman Lee S., Butler-Dawson Jaime, Sorensen Cecilia, Glaser Jason, Miyazaki Makoto, Diaz Henry F., Ishimoto Takuji, Kosugi Tomoki, Maruyama Shoichi, Garcia Gabriela E., Lanaspa Miguel A., Johnson Richard J.

American journal of physiology. Renal physiology Vol. 317 ( 5 ) page： F1111 - F1121 2019.11

Variations in actual practice patterns and their deviations from the clinical practice guidelines for nephrotic syndrome in Japan: certified nephrologists' questionnaire survey Reviewed

Niihata Kakuya, Nishiwaki Hiroki, Kurita Noriaki, Okada Hirokazu, Maruyama Shoichi, Narita Ichiei, Shibagaki Yugo, Nakaya Izaya

Clin Exp Nephrol Vol. 23 ( 11 ) page： 1288 - 1297 2019.11

Circulating levels of CD34(+) cells predict longterm cardiovascular outcomes in patients on maintenance hemodialysis Reviewed

Kaihan Ahmad Baseer, Hishida Manabu, Imaizumi Takahiro, Okazaki Masaki, Kaihan Ahmad Naseer, Katsuno Takayuki, Taguchi Akihiko, Yasuda Yoshinari, Tsuboi Naotake, Kosugi Tomoki, Maruyama Shoichi

PLoS One Vol. 14 ( 10 ) page： e0223390 2019.10

Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase Reviewed

Hayasaki Takahiro, Ishimoto Takuji, Doke Tomohito, Hirayama Akiyoshi, Soga Tomoyoshi, Furuhashi Kazuhiro, Kato Noritoshi, Kosugi Tomoki, Tsuboi Naotake, Lanaspa Miguel A., Johnson Richard J., Maruyama Shoichi, Kadomatsu Kenji

J Nutr Biochem Vol. 71 page： 54 - 62 2019.9

Connective tissue growth factor is correlated with peritoneal lymphangiogenesis Reviewed

Kinashi Hiroshi, Toda Naohiro, Sun Ting, Nguyen Tri Q., Suzuki Yasuhiro, Katsuno Takayuki, Yokoi Hideki, Aten Jan, Mizuno Masashi, Maruyama Shoichi, Yanagita Motoko, Goldschmeding Roel, Ito Yasuhiko

Sci Rep Vol. 9 ( 1 ) page： 12175 2019.8

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction Reviewed

Hara Akitoshi, Kobayashi Hiroki, Asai Naoya, Saito Shigeyoshi, Higuchi Takahiro, Kato Katsuhiro, Okumura Takahiro, Bando Yasuko K., Takefuji Mikito, Mizutani Yasuyuki, Miyai Yuki, Saito Shoji, Maruyama Shoichi, Maeda Keiko, Ouchi Noriyuki, Nagasaka Arata, Miyata Takaki, Mii Shinji, Kioka Noriyuki, Worthley Daniel L., Murohara Toyoaki, Takahashi Masahide, Enomoto Atsushi

Circ Res Vol. 125 ( 4 ) page： 414 - 430 2019.8

miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury Reviewed

Funahashi Yoshio, Kato Noritoshi, Masuda Tomohiro, Nishio Fumitoshi, Kitai Hiroki, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Matsuda Naoyuki, Maruyama Shoichi, Kadomatsu Kenji

Lab Invest Vol. 99 ( 8 ) page： 1130 - 1142 2019.8

The effect of maintaining high hemoglobin levels on long-term kidney function in kidney transplant recipients: a randomized controlled trial Reviewed

Tsujita Makoto, Kosugi Tomoki, Goto Norihiko, Futamura Kenta, Nishihira Morikuni, Okada Manabu, Hiramitsu Takahisa, Narumi Shunji, Uchida Kazuharu, Takeda Asami, Morozumi Kunio, Maruyama Shoichi, Watarai Yoshihiko

Nephrol Dial Transplant Vol. 34 ( 8 ) page： 1409 - 1416 2019.8

CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling Reviewed

Yoshioka Tomoki, Kosugi Tomoki, Masuda Tomohiro, Watanabe Tomoharu, Ryuge Akihiro, Nagaya Hiroshi, Maeda Kayaho, Sato Yuka, Katsuno Takayuki, Kato Noritoshi, Ishimoto Takuji, Yuzawa Yukio, Maruyama Shoichi, Kadomatsu Kenji

Am J Pathol Vol. 189 ( 7 ) page： 1338 - 1350 2019.7

Association Between Tonsillectomy and Outcomes in Patients With Immunoglobulin A Nephropathy Reviewed

Hirano Keita, Matsuzaki Keiichi, Yasuda Takashi, Nishikawa Masako, Yasuda Yoshinari, Koike Kentaro, Maruyama Shoichi, Yokoo Takashi, Matsuo Seiichi, Kawamura Tetsuya, Suzuki Yusuke

JAMA Netw Open Vol. 2 ( 5 ) page： e194772 2019.5

Effects of long-term treatment with low-GDP, pH-neutral solutions on peritoneal membranes in peritoneal dialysis patients Reviewed

Tawada Mitsuhiro, Hamada Chieko, Suzuki Yasuhiro, Sakata Fumiko, Sun Ting, Kinashi Hiroshi, Katsuno Takayuki, Takei Yoshifumi, Maruyama Shoichi, Honda Kazuho, Mizuno Masashi, Ito Yasuhiko

Clin Exp Nephrol Vol. 23 ( 5 ) page： 689 - 699 2019.5

Temporal change in life and renal prognosis of rapidly progressive glomerulonephritis in Japan via nationwide questionnaire survey. Reviewed

Yamagata K, Usui J, Sugiyama H, Maruyama S, Narita I

Clin Exp Nephrol Vol. 23 ( 4 ) page： 573 - 575 2019.4

A grading system that predicts the risk of dialysis induction in IgA nephropathy patients based on the combination of the clinical and histological severity. Reviewed

Okonogi H, Kawamura T, Joh K, Koike K, Miyazaki Y, Ogura M, Tsuboi N, Hirano K, Matsushima M, Yokoo T, Horikoshi S, Suzuki Y, Yasuda T, Shirai S, Shibata T, Hattori M, Akioka Y, Katafuchi R, Hashiguchi A, Hisano S, Shimizu A, Kimura K, Maruyama S, Matsuo S, Tomino Y, Special IgA Nephropathy Study Group.

Clin Exp Nephrol Vol. 23 ( 1 ) page： 16 - 25 2019.1

Increase of Eosinophil in Dialysate During Induction of Peritoneal Dialysis. Reviewed

Shigemoto Emi, Mizuno Masashi, Suzuki Yasuhiro, Kobayashi Kazuma, Sakata Fumiko, Kariya Tetsuyoshi, Katsuno Takayuki, Maruyama Shoichi, Ito Yasuhiko

Perit Dial Int Vol. 39 ( 1 ) page： 90 - 92 2019

Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease Reviewed

Ozeki Takaya, Katsuno Takayuki, Hayashi Hiroki, Kato Sawako, Yasuda Yoshinari, Ando Masahiko, Tsuboi Naotake, Hagiwara Daisuke, Arima Hiroshi, Maruyama Shoichi

Am J Nephrol Vol. 49 ( 1 ) page： 54 - 63 2019

Regional variations in immunosuppressive therapy in patients with primary nephrotic syndrome: the Japan nephrotic syndrome cohort study. Reviewed

Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Nitta K, Tsukamoto T, Uchida S, Takeda A, Sato T, Wada T, Hayashi H, Akai Y, Fukunaga M, Tsuruya K, Masutani K, Konta T, Shoji T, Hiramatsu T, Goto S, Tamai H, Nishio S, Shirasaki A, Nagai K, Yamagata K, Hasegawa H, Yasuda H, Ichida S, Naruse T, Fukami K, Nishino T, Sobajima H, Tanaka S, Akahori T, Ito T, Yoshio T, Katafuchi R, Fujimoto S, Okada H, Ishimura E, Kazama JJ, Hiromura K, Mimura T, Suzuki S, Saka Y, Sofue T, Suzuki Y, Shibagaki Y, Kitagawa K, Morozumi K, Fujita Y, Mizutani M, Shigematsu T, Kashihara N, Sato H, Matsuo S, Narita I, Isaka Y

Clin Exp Nephrol Vol. 22 ( 6 ) page： 1266 - 1280 2018.12

A Refractory Case of Secondary Membranous Nephropathy Concurrent with IgG4-related Tubulointerstitial Nephritis. Reviewed

Arai H, Toda N, Kamimatsuse R, Nishioka K, Endo S, Akiyama S, Maruyama S, Matsubara T, Yokoi H, Yanagita M

Internal medicine (Tokyo, Japan) Vol. 57 ( 19 ) page： 2873 - 2877 2018.10

The association between intensive care unit-acquired hypernatraemia and mortality in critically ill patients with cerebrovascular diseases: a single-centre cohort study in Japan. Reviewed

Imaizumi T, Nakatochi M, Fujita Y, Nomura R, Watanabe K, Maekawa M, Yamakawa T, Katsuno T, Maruyama S

BMJ open Vol. 7 ( 8 ) page： e016248 2017.8

Calcineurin Inhibitor-Induced Pain Syndrome in ABO-Incompatible Living Kidney Transplantation: A Case Report Reviewed

Ishida S., Kato M., Fujita T., Funahashi Y., Sassa N., Matsukawa Y., Yoshino Y., Yamamoto T., Katsuno T., Maruyama S., Gotoh M.

Transplant Proc Vol. 49 ( 1 ) page： 163 - 166 2017

Clinical guides for atypical hemolytic uremic syndrome in Japan. Reviewed

Kato H, Nangaku M, Hataya H, Sawai T, Ashida A, Fujimaru R, Hidaka Y, Kaname S, Maruyama S, Yasuda T, Yoshida Y, Ito S, Hattori M, Miyakawa Y, Fujimura Y, Okada H, Kagami S; Joint Committee for the Revision of Clinical Guides of Atypical Hemolytic Uremic Syndrome in Japan.

Clin Exp Nephrol Vol. 20 ( 4 ) page： 536 - 543 2016.9

Antineutrophil Cytoplasmic Antibody-associated Vasculitis Superimposed on Infection-related Glomerulonephritis Secondary to Pulmonary Mycobacterium avium Complex Infection. Reviewed

Asano S, Mizuno S, Okachi S, Aso H, Wakahara K, Hashimoto N, Ito S, Kozaki Y, Katsuno T, Maruyama S, Hasegawa Y.

Intern Med Vol. 55 ( 17 ) page： 2439 - 2445 2016.8

Clinical guides for atypical hemolytic uremic syndrome in Japan. Reviewed

Pediatr Int Vol. 58 ( 7 ) page： 549 - 555 2016.8

Phospholipase A2 Receptor-Positive Idiopathic Membranous Glomerulonephritis with Onset at 95 Years: Case Report. Reviewed

Kubota K, Hoshino J, Ueno T, Mise K, Hazue R, Sekine A, Yabuuchi J, Yamanouchi M, Suwabe T, Kikuchi K, Sumida K, Hayami N, Sawa N, Takaichi K, Fujii T, Ohashi K, Akiyama S, Maruyama S, Ubara Y.

Case Rep Nephrol Dial Vol. 6 ( 2 ) page： 76 - 82 2016.7

Urinary soluble CD163 level reflects glomerular inflammation in human lupus nephritis. Reviewed

Endo N, Tsuboi N, Furuhashi K, Shi Y, Du Q, Abe T, Hori M, Imaizumi T, Kim H, Katsuno T, Ozaki T, Kosugi T, Matsuo S, Maruyama S.

Nephrol Dial Transplant Vol. 31 ( 12 ) page： 2023 - 2033 2016.5

Randomized control trial for the assessment of the anti-albuminuric effects of topiroxostat in hyperuricemic patients with diabetic nephropathy (the ETUDE study). Reviewed

Kato S, Ando M, Mizukoshi T, Nagata T, Katsuno T, Kosugi T, Tsuboi N, Maruyama S.

Nagoya J Med Sci Vol. 78 ( 2 ) page： 135 - 142 2016.5

Association between 24h Urinary Sodium and Potassium Excretion and Estimated Glomerular Filtration Rate (eGFR) Decline or Death in Patients with Diabetes Mellitus and eGFR More than 30 ml/min/1.73m2. Reviewed

Nagata T, Sobajima H, Ohashi N, Hirakawa A, Katsuno T, Yasuda Y, Matsuo S, Tsuboi N, Maruyama S.

PLoS One Vol. 11 ( 5 ) page： e0152306 2016.5

Ischemic Acute Tubular Necrosis due to Diltiazem Overdose. Reviewed

Ryuge A, Shimizu H, Ohyama Y, Yamaguchi M, Nomura A, Maruyama S, Kitamura H, Fujita Y.

Intern Med Vol. 55 ( 9 ) page： 1149 - 1151 2016.5

High Ferritin Level and Malnutrition Predict High Risk of Infection-Related Hospitalization in Incident Dialysis Patients: A Japanese Prospective Cohort Study. Reviewed

Kato S, Lindholm B, Yuzawa Y, Tsuruta Y, Nakauchi K, Yasuda K, Sugiura S, Morozumi K, Tsuboi N, Maruyama S.

Blood Purif Vol. 42 ( 1 ) page： 56 - 63 2016.4

The effectiveness and safety of modest exercise in Japanese patients with chronickidney disease: a single-armed interventional study. Reviewed

Masami Hamada, Yoshinari Yasuda, Sawako Kato, Hiroki Arafuka, Motomitsu Goto, Mutsuharu Hayashi, Etsuko Kajita, Shoichi Maruyama

Clin Exp Nephrol Vol. 20 ( 2 ) page： 204 - 211 2016.4

Identification of C1q as a Binding Protein for Advanced Glycation End Products. Reviewed

Chikazawa M, Shibata T, Hatasa Y, Hirose S, Otaki N, Nakashima F, Ito M, Machida S, Maruyama S, Uchida K.

Biochemistry Vol. 55 ( 3 ) page： 435 - 446 2016.1

Urinary Podocalyxin as a Biomarker to Diagnose Membranous Nephropathy. Reviewed

Imaizumi T, Nakatochi M, Akiyama S, Yamaguchi M, Kurosawa H, Hirayama Y, Katsuno T, Tsuboi N, Hara M, Maruyama S.

PLoS One Vol. 11 ( 9 ) page： e0163507 2016

Vascular Endothelial Cell Injury Is an Important Factor in the Development of Encapsulating Peritoneal Sclerosis in Long-Term Peritoneal Dialysis Patients. Reviewed

Tawada M, Ito Y, Hamada C, Honda K, Mizuno M, Suzuki Y, Sakata F, Terabayashi T, Matsukawa Y, Maruyama S, Imai E, Matsuo S, Takei Y.

PLoS One Vol. 11 ( 4 ) page： e0154644 2016

In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy. Reviewed

Serino G, Pesce F, Sallustio F, De Palma G, Cox SN, Curci C, Zaza G, Lai KN, Leung JC, Tang SC, Papagianni A, Stangou M, Goumenos D, Gerolymos M, Takahashi K, Yuzawa Y, Maruyama S, Imai E, Schena FP.

Kidney Int Vol. 89 ( 3 ) page： 683 - 692 2015.11

Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease. Reviewed

Kato S, Shiels PG, McGuinness D, Lindholm B, Stenvinkel P, Nordfors L, Qureshi AR, Yuzawa Y, Matsuo S, Maruyama S.

Blood Purif Vol. 41 ( 1-3 ) page： 25 - 33 2015.10

Therapeutic Potential of Stem Cells from Human Exfoliated Deciduous Teeth in Models of Acute Kidney Injury. Reviewed

Hattori Y, Kim H, Tsuboi N, Yamamoto A, Akiyama S, Shi Y, Katsuno T, Kosugi T, Ueda M, Matsuo S, Maruyama S.

PLoS One Vol. 10 ( 10 ) page： e0140121 2015.10

Increase of Antimyeloperoxidase Antineutrophil Cytoplasmic Antibody (ANCA) in Patients with Renal ANCA-associated Vasculitis: Association with Risk to Relapse. Reviewed

Yamaguchi M, Ando M, Kato S, Katsuno T, Kato N, Kosugi T, Sato W, Tsuboi N, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S.

J Rheumatol Vol. 42 ( 10 ) page： 1853 - 1860 2015.10

Impact of abdominal aortic calcification on long-term cardiovascular outcomes in patients with chronic kidney disease. Reviewed

Tatami Y, Yasuda Y, Suzuki S, Ishii H, Sawai A, Shibata Y, Ota T, Shibata K, Niwa M, Morimoto R, Hayashi M, Kato S, Maruyama S, Murohara T.

Atherosclerosis Vol. 243 ( 2 ) page： 349 - 355 2015.10

Neutrophil/lymphocyte ratio as a predictor of cardiovascular events in incident dialysis patients: a Japanese prospective cohort study. Reviewed

Abe T1, Kato S, Tsuruta Y, Sugiura S, Katsuno T, Kosugi T, Tsuboi N, Matsuo S, Maruyama S.

Clin Exp Nephrol Vol. 19 ( 4 ) page： 718 - 724 2015.10

Impact of non-invasive cardiovascular screening programs as a predictor of cardiovascular events among asymptomatic chronic kidney disease patients. Reviewed

Sawai A, Yasuda Y, Suzuki S, Ishii H, Goto M, Kato S, Hayashi M, Maruyama S, Murohara T, Oiso Y, Matsuo S.

Clin Exp Nephrol Vol. 20 ( 3 ) page： 416 - 424 2015.9

Association of Estimated Glomerular Filtration Rate and Proteinuria With Lipid-Rich Plaque in Coronary Artery Disease. Reviewed

Shimbo Y, Suzuki S, Ishii H, Shibata Y, Tatami Y, Harata S, Osugi N, Ota T, Tanaka A, Shibata K, Mizukoshi T, Yasuda Y, Maruyama S, Murohara T.

Circ J Vol. 79 ( 10 ) page： 2263 - 2270 2015.9

Prevalence of anti-phospholipase A2 receptor antibodies in Japanese patients with membranous nephropathy. Reviewed

Akiyama S, Akiyama M, Imai E, Ozaki T, Matsuo S, Maruyama S.

Clin Exp Nephrol Vol. 19 ( 4 ) page： 653 - 660 2015.8

Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids. Reviewed

Sato Y, Sato W, Maruyama S, Wilcox CS, Falck JR, Masuda T, Kosugi T, Kojima H, Maeda K, Furuhashi K, Ando M, Imai E, Matsuo S, Kadomatsu K.

J Am Soc Nephrol Vol. 26 ( 8 ) page： 1806 - 1815 2015.8

CD147 (EMMPRIN/Basigin) in kidney diseases: from an inflammation and immune system viewpoint. Reviewed

Kosugi T1, Maeda K1, Sato W1, Maruyama S1, Kadomatsu K2.

Nephrol Dial Transplant Vol. 30 ( 7 ) page： 1097 - 1103 2015.7

Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy. Reviewed

Sei Y, Mizuno M, Suzuki Y, Imai M, Higashide K, Harris CL, Sakata F, Iguchi D, Fujiwara M, Kodera Y, Maruyama S, Matsuo S, Ito Y.

Mol Immunol Vol. 65 ( 2 ) page： 302 - 309 2015.6

Rationale and study design of a randomized controlled trial to assess the effects of maintaining hemoglobin levels using darbepoetin alfa on prevention of development of end-stage kidney disease in non-diabetic CKD patients (PREDICT Trial). Reviewed

Imai E, Maruyama S, Nangaku M, Hirakata H, Hayashi T, Narita I, Kono H, Nakatani E, Morita S, Tsubakihara Y, Akizawa T.

Clin Exp Nephrol Vol. 20 ( 1 ) page： 71 - 76 2015.6

Relationship between abdominal aortic and coronary artery calcification as detected by computed tomography in chronic kidney disease patients. Reviewed

Takayama Y, Yasuda Y, Suzuki S, Shibata Y, Tatami Y, Shibata K, Niwa M, Sawai A, Morimoto R, Kato S, Ishii H, Maruyama S, Murohara T.

Heart Vessels Vol. 31 ( 7 ) page： 1030 - 1037 2015.6

Clinical impact of kidney function on presepsin levels. Reviewed

Nagata T, Yasuda Y, Ando M, Abe T, Katsuno T, Kato S, Tsuboi N, Matsuo S, Maruyama S.

PLoS One Vol. 10 ( 6 ) page： e0129159 2015.6

Longitudinal Study of the Decline in Renal Function in Healthy Subjects. Reviewed

Baba M, Shimbo T, Horio M, Ando M, Yasuda Y, Komatsu Y, Masuda K, Matsuo S, Maruyama S.

PLoS One Vol. 10 ( 6 ) page： e0129036 2015.6

CD147/Basigin limits lupus nephritis and TH 17 cell differentiation by inhibiting the IL-6/STAT3 pathway. Reviewed

Maeda K, Kosugi T, Sato W, Kojima H, Sato Y, Kamimura D, Kato N, Tsuboi N, Yuzawa Y, Matsuo S, Murakami M, Maruyama S, Kadomatsu K.

Arthritis Rheum Vol. 67 ( 8 ) page： 2185 - 2195 2015.5

Functional Difference Between Membrane-Bound and Soluble Human Thrombomodulin. Reviewed

Miwa Y, Yazaki S, Iwamoto M, Suzuki S, Iwasaki K, Haneda M, Yamamoto K, Maruyama S, Onishi A, Kobayashi T.

Transplantation Vol. 99 ( 4 ) page： 702 - 709 2015.4

The efficacy of tolvaptan as a diuretic for chronic kidney disease patients. Reviewed

Tanaka A, Katsuno T, Ozaki T, Sakata F, Kato N, Suzuki Y, Kosugi T, Kato S, Tsuboi N, Sato W, Yasuda Y, Mizuno M, Ito Y, Matsuo S, Maruyama S.

Acta Cardiol Vol. 70 ( 2 ) page： 217 - 223 2015.4

Vascular endothelial growth factor receptor-3 is a novel target to improve net ultrafiltration in methylglyoxal-induced peritoneal injury. Reviewed

Terabayashi T, Ito Y, Mizuno M, Suzuki Y, Kinashi H, Sakata F, Tomita T, Iguchi D, Tawada M, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.

Lab Invest Vol. 95 ( 9 ) page： 1029 - 1043 2015.4

Renal function evaluation in patients with cancer who were scheduled to receive carboplatin or S-1. Reviewed

Shibata K, Yasuda Y, Kobayashi R, Ando Y, Shimokata T, Kamiya H, Hayashi M, Maruyama S, Matsuo S, Nakao M, Tsuchiya T, Teramachi H.

Clin Exp Nephrol Vol. 19 ( 6 ) page： 1107 - 1113 2015.4

Anti-albuminuric effects of spironolactone in patients with type 2 diabetic nephropathy: a multicenter, randomized clinical trial. Reviewed

Kato S, Maruyama S, Makino H, Wada J, Ogawa D, Uzu T, Araki H, Koya D, Kanasaki K, Oiso Y, Goto M, Nishiyama A, Kobori H, Imai E, Ando M, Matsuo S.

Clin Exp Nephrol Vol. 19 ( 6 ) page： 1098 - 1106 2015.3

Identification of an Interaction between VWF rs7965413 and Platelet Count as a Novel Risk Marker for Metabolic Syndrome: An Extensive Search of Candidate Polymorphisms in a Case-Control Study. Reviewed

Nakatochi M, Ushida Y, Yasuda Y, Yoshida Y, Kawai S, Kato R, Nakashima T, Iwata M, Kuwatsuka Y, Ando M, Hamajima N, Kondo T, Oda H, Hayashi M, Kato S, Yamaguchi M, Maruyama S, Matsuo S, Honda H.

PLoS One Vol. 10 ( 2 ) page： e0117591 2015

Pristane-induced granulocyte recruitment promotes phenotypic conversion of macrophages and protects against diffuse pulmonary hemorrhage in Mac-1 deficiency. Reviewed

Shi Y1, Tsuboi N2, Furuhashi K3, Du Q1, Horinouchi A1, Maeda K1, Kosugi T1, Matsuo S1, Maruyama S1.

J Immunol Vol. 193 ( 10 ) page： 5129 - 5139 2014

CD147/basigin reflects renal dysfunction in patients with acute kidney injury. Reviewed

Nagaya H1, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.

Clin Exp Nephrol Vol. 18 ( 5 ) page： 746 - 754 2014

Smoking is a risk factor for the progression of idiopathic membranous nephropathy. Reviewed

Yamaguchi M1, Ando M2, Yamamoto R3, Akiyama S1, Kato S1, Katsuno T1, Kosugi T1, Sato W1, Tsuboi N1, Yasuda Y1, Mizuno M1, Ito Y1, Matsuo S1, Maruyama S1.

PLoS One Vol. 9 ( 6 ) page： e100835 2014

Plasma CD147 reflects histological features in patients with lupus nephritis. Reviewed

Maeda-Hori M1, Kosugi T, Kojima H, Sato W, Inaba S, Maeda K, Nagaya H, Sato Y, Ishimoto T, Ozaki T, Tsuboi N, Muro Y, Yuzawa Y, Imai E, Johnson RJ, Matsuo S, Kadomatsu K, Maruyama S.

Lupus Vol. 23 ( 4 ) page： 342 - 352 2014

A multicenter cross-sectional study of circulating soluble urokinase receptor in Japanese patients with glomerular disease. Reviewed

Wada T, Nangaku M, Maruyama S, Imai E, Shoji K, Kato S, Endo T, Muso E, Kamata K, Yokoyama H, Fujimoto K, Obata Y, Nishino T, Kato H, Uchida S, Sasatomi Y, Saito T, Matsuo S.

Kidney Int Vol. 85 ( 3 ) page： 641 - 648 2014

Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation. Reviewed

Kim H, Mizuno M, Furuhashi K, Katsuno T, Ozaki T, Yasuda K, Tsuboi N, Sato W, Suzuki Y, Matsuo S, Ito Y, Maruyama S.

Cytotherapy Vol. 16 ( 3 ) page： 357 - 368 2014

A ray of light in the dark: alternative approaches to the assessment and treatment of ischemic nephropathy. Reviewed

Tsuboi N, Maruyama S, Matsuo S, Imai E.

Nephrol Dial Transplant Vol. 29 ( 2 ) page： 228 - 231 2014

Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis. Reviewed

Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K.

Am J Pathol Vol. 182 ( 2 ) page： 410 - 419 2013

TGF-beta1 Promotes Lymphangiogenesis during Peritoneal Fibrosis. Reviewed

Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y.

J Am Soc Nephrol Vol. 24 ( 10 ) page： 1627 - 1642 2013

Perforative peritonitis caused by appendicitis in a patient on peritoneal dialysis. Reviewed

Mizuno M, Suzuki Y, Nonaka K, Sei Y, Maruyama S, Matsuo S, Ito Y.

Intern Med Vol. 52 ( 11 ) page： 1177 - 1181 2013

Anti-C5a complementary peptide ameliorates acute peritoneal injuries induced by neutralization of Crry and CD59. Reviewed

Mizuno T, Mizuno M, Imai M, Suzuki Y, Kushida M, Noda Y, Maruyama S, Okada H, Okada N, Matsuo S, Ito Y.

Am J Physiol Renal Physiol Vol. 305 ( 11 ) page： F1603 - 1616 2013

Serum-Starved Adipose-Derived Stromal Cells Ameliorate Crescentic GN by Promoting Immunoregulatory Macrophages. Reviewed

Furuhashi K, Tsuboi N, Shimizu A, Katsuno T, Kim H, Saka Y, Ozaki T, Sado Y, Imai E, Matsuo S, Maruyama S.

J Am Soc Nephrol Vol. 24 ( 4 ) page： 587 - 603 2013

Multi-specificity of IgM antibodies raised against advanced glycation end products: Involvement of electronegative potential of antigens. Reviewed

Chikazawa M, Otaki N, Shibata T, Miyashita H, Kawai Y, Maruyama S, Toyokuni S, Kitaura Y, Matsuda T, Uchida K.

J Biol Chem Vol. 288 ( 19 ) page： 13204 - 13214 2013

Association of cardiac valvular calcifications and C-reactive protein with cardiovascular mortality in incident hemodialysis patients: a Japanese cohort study. Reviewed

Takahashi H, Ishii H, Aoyama T, Kamoi D, Kasuga H, Ito Y, Yasuda K, Tanaka M, Yoshikawa D, Maruyama S, Matsuo S, Murohara T, Yuzawa Y.

Am J Kidney Dis Vol. 61 ( 2 ) page： 254 - 261 2013

Aliskiren-induced chyloperitoneum in a patient on peritoneal dialysis. Reviewed

Saka Y, Tachi H, Sakurai H, Tawada M, Sawai A, Shimamura Y, Mizuno M, Maruyama S, Matsuo S, Ito Y.

Perit Dial Int Vol. 32 ( 1 ) page： 111 - 113 2012

Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis. Reviewed

Nishiwaki S, Nakayama T, Saito S, Mizuno H, Ozaki T, Takahashi Y, Maruyama S, Nishida T, Murata M, Kojima S, Naoe T.

Int J Hematol Vol. 96 ( 3 ) page： 295 - 300 2012

Impact of diabetes and glycaemic control on peripheral artery disease in Japanese patients with end-stage renal disease: long-term follow-up study from the beginning of haemodialysis. Reviewed

Ishii H, Kumada Y, Takahashi H, Toriyama T, Aoyama T, Tanaka M, Yoshikawa D, Hayashi M, Kasuga H, Yasuda Y, Maruyama S, Matsubara T, Matsuo S, Murohara T.

Diabetologia Vol. 55 ( 5 ) page： 1304 - 1309 2012

Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Reviewed

Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ.

P Natl Acad Sci USA Vol. 109 ( 11 ) page： 4320 - 4325 2012

DNA hypermethylation and inflammatory markers in incident Japanese dialysis patients. Reviewed

Kato S, Lindholm B, Stenvinkel P, Ekström TJ, Luttropp K, Yuzawa Y, Yasuda Y, Tsuruta Y, Maruyama S.

Nephron Extra Vol. 2 ( 1 ) page： 159 - 168 2012

Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats. Reviewed

Katsuno T, Ozaki T, Saka Y, Furuhashi K, Kim H, Yasuda K, Yamamoto T, Sato W, Tsuboi N, Mizuno M, Ito Y, Imai E, Matsuo S, Maruyama S.

Cell Transplant Vol. 22 ( 2 ) page： 287 - 289 2012

Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy. Reviewed

Hirayama A, Nakashima E, Sugimoto M, Akiyama SI, Sato W, Maruyama S, Matsuo S, Tomita M, Yuzawa Y, Soga T.

Anal Bioanal Chem Vol. 404 ( 10 ) page： 3101 - 3109 2012

Asymptomatic diverticulosis identified by computed tomography is not a risk factor for enteric peritonitis. Reviewed

Toda S, Ito Y, Mizuno M, Suzuki Y, Ito I, Hiramatsu H, Ozaki T, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.

Nephrol Dial Transplant Vol. 27 ( 6 ) page： 2511 - 2516 2012

Distribution of hydrogen sulfide (H(2)S)-producing enzymes and the roles of the H(2)S donor sodium hydrosulfide in diabetic nephropathy. Reviewed

Yamamoto J, Sato W, Kosugi T, Yamamoto T, Kimura T, Taniguchi S, Kojima H, Maruyama S, Imai E, Matsuo S, Yuzawa Y, Niki I.

Clin Exp Nephrol Vol. 17 ( 1 ) page： 32 - 40 2012

Combined Values of Serum Albumin, C-Reactive Protein and Body Mass Index at Dialysis Initiation Accurately Predicts Long-Term Mortality. Reviewed

Takahashi R, Ito Y, Takahashi H, Ishii H, Kasuga H, Mizuno M, Suzuki Y, Yuzawa Y, Maruyama S, Murohara T, Imai E, Matsuo S.

Am J Nephrol Vol. 36 ( 2 ) page： 136 - 143 2012

Autologous cell therapy for cisplatin-induced acute kidney injury by using non-expanded adipose tissue-derived cells. Reviewed

Yasuda K, Ozaki T, Saka Y, Yamamoto T, Gotoh M, Ito Y, Yuzawa Y, Matsuo S, Maruyama S.

Cytotherapy Vol. 14 ( 9 ) page： 1089 - 1100 2012

Complete remission within 2 years predicts a good prognosis after methylprednisolone pulse therapy in patients with IgA nephropathy. Reviewed

Tatematsu M, Yasuda Y, Morita Y, Sakamoto I, Kurata K, Naruse T, Yamamoto R, Tsuboi N, Sato W, Imai E, Matsuo S, Maruyama S.

Clin Exp Nephrol Vol. 16 ( 6 ) page： 883 - 891 2012

microRNA-Induced IgA Nephropathy. Reviewed

Imai E, Maruyama S.

J Am Soc Nephrol Vol. 23 ( 5 ) page： 765 - 766 2012

A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin. Reviewed

Ito I, Ito Y, Mizuno M, Suzuki Y, Yasuda K, Ozaki T, Kosugi T, Yasuda Y, Sato W, Tsuboi N, Maruyama S, Imai E, Matsuo S.

Clin Exp Nephrol Vol. 16 ( 3 ) page： 490 - 494 2012

Percutaneous coronary intervention with bare metal stent vs. drug-eluting stent in hemodialysis patients. Reviewed

Ishii H, Toriyama T, Aoyama T, Takahashi H, Tanaka M, Yoshikawa D, Hayashi M, Yasuda Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Circ J Vol. 76 ( 7 ) page： 1609 - 1615 2012

Transforming growth factor-β induces vascular endothelial growth factor-C expression leading to lymphangiogenesis in rat unilateral ureteral obstruction. Reviewed

Suzuki Y, Ito Y, Mizuno M, Kinashi H, Sawai A, Noda Y, Mizuno T, Shimizu H, Fujita Y, Matsui K, Maruyama S, Imai E, Matsuo S, Takei Y.

Kidney int Vol. 81 ( 9 ) page： 865 - 879 2012

Production of cloned pigs expressing human thrombomodulin in endothelial cells. Reviewed

Satoko Yazaki, Masaki Iwamoto, Akira Onishi, Yuko Miwa, Michiko Hashimoto, Takatsugu Oishi, Shunichi Suzuki, Dai-ichiro Fuchimoto, Shoichiro Sembon, Tadashi Furusawa, DaGe Liu, Takaharu Nagasaka, Takafumi Kuzuya, Haruko Ogawa, Koji Yamamoto, Kenta Iwasaki, Masataka Haneda, Shoichi Maruyama, and Takaaki Kobayashi

Xenotransplantation Vol. 19 ( 2 ) page： 82 - 91 2012

Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin. Reviewed

Kato K, Kosugi T, Sato W, Arata-Kawai H, Ozaki T, Tsuboi N, Ito I, Tawada H, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.

Clin Exp Nephrol Vol. 15 ( 3 ) page： 346 - 354 2011

Functional consequences of inhibiting exocytosis of Weibel-Palade bodies in acute renal ischemia. Reviewed

Yasuda K, Vasko R, Hayek P, Ratliff B, Bicer H, Mares J, Maruyama S, Bertuglia S, Mascagni P, Goligorsky MS.

Am J Physiol Renal Physiol Vol. 302 ( 6 ) page： F713 - 721 2011

A case of perforative peritonitis caused by a piece of bamboo in a patient on peritoneal dialysis. Reviewed

Suzuki Y, Mizuno M, Nakashima R, Hiramatsu H, Toda S, Sato W, Tsuboi N, Ito I, Maruyama S, Imai E, Matsuo S, Ito Y.

Clin Exp Nephrol Vol. 15 ( 6 ) page： 962 - 965 2011

Validation of the equations for estimating daily sodium excretion from spot urine in patients with chronic kidney disease. Reviewed

Imai E, Yasuda Y, Horio M, Shibata K, Kato S, Mizutani Y, Imai J, Hayashi M, Kamiya H, Oiso Y, Murohara T, Maruyama S, Matsuo S.

Clin Exp Nephrol Vol. 15 ( 6 ) page： 861 - 867 2011

Low-serum culture system improves the adipogenic ability of visceral adipose tissue-derived stromal cells. Reviewed

Nagasaki H, Shang Q, Suzuki T, Hashimoto H, Yoshimura T, Kondo TA, Ozaki T, Maruyama S, Jomori T, Oiso Y, Hamada Y.

Cell Biol Int Vol. 35 ( 6 ) page： 559 - 568 2011

A Case of Acute Renal Failure Caused by Cholesterol Embolization after Carotid Artery Stenting that was Improved by Peritoneal Dialysis. Reviewed

Mizuno M, Ito Y, Hayasaki T, Suzuki Y, Hiramatsu H, Toda S, Mizuno T, Tatematsu M, Ozaki T, Yasuda Y, Sato W, Tsuboi N, Ito I, Maruyama S, Imai E, Matsuo S.

Intern Med Vol. 50 ( 16 ) page： 1719 - 1723 2011

Association of Adiponectin with Carotid Arteriosclerosis in Predialysis Chronic Kidney Disease. Reviewed

Hayashi M, Shibata R, Takahashi H, Ishii H, Aoyama T, Kasuga H, Yamada S, Ohashi K, Maruyama S, Matsuo S, Ouchi N, Murohara T, Toriyama T.

Am J Nephrol Vol. 34 ( 3 ) page： 249 - 255 2011

Tunneling nanotubes mediate rescue of prematurely senescent endothelial cells by endothelial progenitors: exchange of lysosomal pool. Reviewed

Yasuda K, Khandare A, Burianovskyy L, Maruyama S, Zhang F, Nasjletti A, Goligorsky MS.

Aging (Albany NY) Vol. 3 ( 6 ) page： 597 - 608 2011

Increased urethral resistance by periurethral injection of low serum cultured adipose-derived mesenchymal stromal cells in rats. Reviewed

Watanabe T, Maruyama S, Yamamoto T, Kamo I, Yasuda K, Saka Y, Ozaki T, Yuzawa Y, Matsuo S, Gotoh M.

Int J Urol Vol. 18 ( 9 ) page： 659 - 666 2011

Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan. Reviewed

Mizuno M, Ito Y, Tanaka A, Suzuki Y, Hiramatsu H, Watanabe M, Tsuruta Y, Matsuoka T, Ito I, Tamai H, Kasuga H, Shimizu H, Kurata H, Inaguma D, Hiramatsu T, Horie M, Naruse T, Maruyama S, Imai E, Yuzawa Y, Matsuo S.

Clin Exp Nephrol Vol. 15 ( 5 ) page： 727 - 737 2011

Adipose-derived stromal cells cultured in a low-serum medium, but not bone marrow-derived stromal cells, impede xenoantibody production. Reviewed

Saka Y, Furuhashi K, Katsuno T, Kim H, Ozaki T, Iwasaki K, Haneda M, Sato W, Tsuboi N, Ito Y, Matsuo S, Kobayashi T, Maruyama S.

Xenotransplantation Vol. 18 ( 3 ) page： 196 - 208 2011

Atrial natriuretic peptide ameliorates peritoneal fibrosis in rat peritonitis model. Reviewed

Kato H, Mizuno T, Mizuno M, Sawai A, Suzuki Y, Kinashi H, Nagura F, Maruyama S, Noda Y, Yamada K, Matsuo S, Ito Y.

Nephrol Dial Transplant Vol. 27 ( 2 ) page： 526 - 536 2011

Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. Reviewed

Kato N, Kosugi T, Sato W, Ishimoto T, Kojima H, Sato Y, Sakamoto K, Maruyama S, Yuzawa Y, Matsuo S, Kadomatsu K.

Am J Pathol Vol. 178 ( 2 ) page： 572 - 579 2011

Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney. Reviewed

Saito S, Murakumo Y, Tsuzuki T, Dambara A, Kato T, Enomoto A, Asai N, Maruyama S, Matsuo S, Takahashi M.

Hum Pathol Vol. 42 ( 6 ) page： 848 - 858 2011

A case of fulminant peritonitis caused by Streptococcus mitis in a patient on peritoneal dialysis. Reviewed

Mizuno M, Ito Y, Masuda T, Toda S, Hiramatsu H, Suzuki Y, Ozaki T, Yasuda Y, Ito I, Tsuboi N, Sato W, Maruyama S, Imai E, Matsuo S.

Intern Med Vol. 50 ( 5 ) page： 471 - 474 2011

Prognostic Value of Reduced Left Ventricular Ejection Fraction at Start of Hemodialysis Therapy on Cardiovascular and All-Cause Mortality in End-Stage Renal Disease Patients. Reviewed

Yamada S, Ishii H, Takahashi H, Aoyama T, Morita Y, Kasuga H, Kimura K, Ito Y, Takahashi R, Toriyama T, Yasuda Y, Hayashi M, Kamiya H, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Clinical journal of the American Society of Nephrology Vol. 5 ( 10 ) page： 1793 - 1798 2010.7

Acute kidney injury presenting a feature of leukemic infiltration during therapy for chronic myelogenous leukemia. Reviewed

Yuzawa Y, Sato W, Masuda T, Hamada Y, Tatematsu M, Yasuda Y, Ozaki T, Ito I, Mizuno M, Maruyama S, Ito Y, Matsuo S

Internal Medicine Vol. 49 ( 12 ) page： 1139 - 1142 2010.6

Effects of oral cilostazol 100 mg BID on long-term patency after percutaneous transluminal angioplasty in patients with femoropopliteal disease undergoing hemodialysis: a retrospective chart review in Japanese patients. Reviewed

Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Tanaka M, Kamoi D, Kawamura Y, Yamada S, Hayashi M, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Clinical therapeutics Vol. 32 ( 1 ) page： 24 - 33 2010.6

Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysis. Reviewed

Fadini GP, Maruyama S, Ozaki T, Taguchi A, Meigs J, Dimmeler S, Zeiher AM, de Kreutzenberg S, Avogaro A, Nickenig G, Schmidt-Lucke C, Werner N.

PLoS One Vol. 5 ( 7 ) page： e11488 2010.6

Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. Reviewed

Kurata K, Maruyama S, Kato S, Sato W, Yamamoto J, Ozaki T, Nitta A, Nabeshima T, Morita Y, Mizuno M, Ito Y, Yuzawa Y, Matsuo S.

American journal of physiology-Renal physiology Vol. 297 ( 6 ) page： F1510 - 1517 2009.12

Successful cross-breeding of cloned pigs expressing endo-beta-galactosidase C and human decay accelerating factor. Reviewed

Yazaki S, Iwamoto M, Onishi A, Miwa Y, Suzuki S, Fuchimoto D, Sembon S, Furusawa T, Hashimoto M, Oishi T, Liu D, Nagasaka T, Kuzuya T, Maruyama S, Ogawa H, Kadomatsu K, Uchida K, Nakao A, Kobayashi T

Xenotransplantation Vol. 16 ( 6 ) page： 511 - 521 2009.9

Prognostic values of C-reactive protein levels on clinical outcome after implantation of sirolimus-eluting stents in patients on hemodialysis. Reviewed

Ishii H, Toriyama T, Aoyama T, Takahashi H, Amano T, Hayashi M, Tanaka M, Kawamura Y, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Circulation: Cardiovascular Interventions Vol. 2 ( 6 ) page： 513 - 518 2009.9

Aortic valvular calcification predicts restenosis after implantation of drug-eluting stents in patients on chronic haemodialysis. Reviewed

Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Amano T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Nephrology dialysis transplantation Vol. 24 ( 5 ) page： 1562 - 1567 2009.8

A murine model of neonatal diabetes mellitus in Glis3-deficient mice. Reviewed

Watanabe N, Hiramatsu K, Miyamoto R, Yasuda K, Suzuki N, Oshima N, Kiyonari H, Shiba D, Nishio S, Mochizuki T, Yokoyama T, Maruyama S, Matsuo S, Wakamatsu Y, Hashimoto H.

FEBS Letter Vol. 583 ( 12 ) page： 2108 - 2113 2009.6

Novel culture system of mesenchymal stromal cells from human subcutaneous adipose tissue. Reviewed

Iwashima S, Ozaki T, Maruyama S, Saka Y, Kobori M, Omae K, Yamaguchi H, Niimi T, Toriyama K, Kamei Y, Torii S, Murohara T, Yuzawa Y, Kitagawa Y, Matsuo S.

Stem Cells and Development Vol. 18 ( 4 ) page： 533 - 543 2009.5

The growth factor midkine regulates the renin-angiotensin system in mice. Reviewed

Hobo A, Yuzawa Y, Kosugi T, Kato N, Asai N, Sato W, Maruyama S, Ito Y, Kobori H, Ikematsu S, Nishiyama A, Matsuo S, Kadomatsu K.

Journal of Clinical Investigation Vol. 19 ( 6 ) page： 1616 - 1625 2009.5

Lymphatic vessels develop during tubulointerstitial fibrosis. Reviewed

Sakamoto I, Ito Y, Mizuno M, Suzuki Y, Sawai A, Tanaka A, Maruyama S, Takei Y, Yuzawa Y, Matsuo S.

Kidney International Vol. 75 ( 8 ) page： 828 - 823 2009.4

Kidney regeneration through nephron neogenesis in medaka. Reviewed

Watanabe N, Kato M, Suzuki N, Inoue C, Fedorova S, Hashimoto H, Maruyama S, Matsuo S, Wakamatsu Y.

Development Growth and Differentiation Vol. 51 ( 2 ) page： 135 - 143 2009.2

Removal of blood group A/B antigen in organs by ex vivo and in vivo administration of endo-beta-galactosidase (ABase) for ABO-incompatible transplantation. Reviewed

Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Li YT, Onishi A, Iwamoto M, Kuzuya T, Kadomatsu K, Uchida K, Nakao A.

Transplant immunology Vol. 20 ( 3 ) page： 132 - 138 2008.10

Efficiency of laparoscopic-assisted renal biopsy. Reviewed

Anas CM, Hattori R, Morita Y, Matsukawa Y, Komatsu T, Yoshino Y, Maruyama S, Yuzawa Y, Matsuo S, Gotoh M.

Clinical Nephrology Vol. 70 ( 3 ) page： 203 - 209 2008.9

Low circulating CD34+ cell count is associated with poor prognosis in chronic hemodialysis patients. Reviewed

Shoichi Maruyama1, Akihiko Taguchi2, Shigejiro Iwashima1, Takenori Ozaki1, Kaoru Yasuda1, Akie Kikuchi-Taura3, Toshihiro Soma3, Hideki Ishii4, Toyoaki Murohara4, Hiroshi Takahashi5, Hirotake Kasuga5, Yoshitaka Kumada6, Takanobu Toriyama5, Yasuhiko Ito1, Hirohisa Kawahara5, Yukio Yuzawa1 and Seiichi Matsuo1

Kidney international Vol. 74 ( 12 ) page： 1603 - 1609 2008.8

Intrarenal administration of recombinant human soluble thrombomodulin ameliorates ischaemic acute renal failure. Reviewed

Ozaki T, Anas C, Maruyama S, Yamamoto T, Yasuda K, Morita Y, Ito Y, Gotoh M, Yuzawa Y, Matsuo S.

Nephrology dialysis transplantation Vol. 23 ( 1 ) page： 110 - 119 2008.6

Lipid droplet-associated proteins protect renal tubular cells from fatty acid-induced apoptosis. Reviewed

Urahama Y, Ohsaki Y, Fujita Y,Maruyama S, Yuzawa Y, Matsuo S, Fujimoto T.

Ameircan journal of Pathology Vol. 173 ( 5 ) page： 1286 - 1294 2008

Long-term outcome of percutaneous transluminal angioplasty in chronic haemodialysis patients with peripheral arterial disease. Reviewed

Kumada Y, Aoyama T, Ishii H, Tanaka M, Kawamura Y, Takahashi H, Toriyama T, Aoyama T, Yuzawa Y, Maruyama S, Matsuo S, Murohara T.

Nephrology dialysis transplantation Vol. 23 ( 10 ) page： 3996 - 4001 2008

Overexpression of Calmodulin in Pancreatic {beta} Cells Induces Diabetic Nephropathy. Reviewed

Yuzawa Y, Niki I, Kosugi T, Maruyama S, Yoshida F, Takeda M, Tagawa Y, Kaneko Y, Kimura T, Kato N, Yamamoto J, Sato W, Nakagawa T, Matsuo S.

Journal of the American Society of Nephrology Vol. 19 ( 9 ) page： 1701 - 1711 2008

Cilostazol Improves Long-Term Patency after Percutaneous Transluminal Angioplasty in Hemodialysis Patients with Peripheral Artery Disease. Reviewed

Ishii H, Kumada Y, Toriyama T, Aoyama T, Takahashi H, Yamada S, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T.

Clinical journal of the American Society of Nephrology Vol. 3 ( 4 ) page： 1034 - 1040 2008

Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. Reviewed

Nishimura H, Ito Y, Mizuno M, Tanaka A, Morita Y, Maruyama S, Yuzawa Y, Matsuo S.

American journal of physiology. Renal physiology Vol. 294 ( 5 ) page： F1084 - 1093 2008

Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis. Reviewed

Aoyama T, Ishii H, Toriyama T, Takahashi H, Kasuga H, Murakami R, Amano T,Uetani T, Yasuda Y, Yuzawa Y, Maruyama S, Matsuo S, Matsubara T, Murohara T

Circulation journal Vol. 72 ( 1 ) page： 56 - 60 2008

High mobility group box chromosomal protein 1 in patients with renal diseases. Reviewed

Fumihiko Sato, Shoichi Maruyama, Hiroki Hayashi, Izumi Sakamoto, Shingo Yamada, Tomonori Uchimura, Yoshiki Morita, Yasuhiko Ito, Yukio Yuzawa, Ikuro Maruyama, Seiichi Matsuo

Nephron Clinical Practice Vol. 108 ( 3 ) page： c194 - c201 2008

Alternative strategy for overcoming ABO incompatibility. Reviewed

Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Li YT, Onishi A, Kuzuya T, Kadomatsu K, Uchida K, Nakao A.

Transplantation. Vol. 83 ( 9 ) page： 1284 - 1286 2007.5

Efficacy of oral nicorandil in patients with end-stage renal disease: a retrospective chart review after coronary angioplasty in Japanese patients receiving hemodialysis. Reviewed

Ishii H, Toriyama T, Aoyama T, Takahashi H, Yamada S, Kasuga H, Ichimiya S, Kanashiro M, Mitsuhashi H, Maruyama S, Matsuo S, Naruse K, Matsubara T, Murohara T.

Clin Ther. Vol. 29 ( 1 ) page： 110 - 122 2007.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Patients receiving hemodialysis for end-stage renal disease (ESRD) are at high risk for death from ischemic heart disease (IHD). Nicorandil, a hybrid compound of adenosine triphosphate-sensitive potassium channel opener and nitric oxide donor, has been reported to improve the clinical prognosis of patients with IHD. OBJECTIVE: This study sought to investigate the efficacy of oral nicorandil in reducing the risks for cardiovascular events (CVEs) and CVE-related death in patients receiving hemodialysis for ESRD after undergoing percutaneous coronary intervention (PCI) for angina pectoris. METHODS: For this retrospective chart review, we used data from telephone interviews and medical charts from 3 hospitals in Japan. Data from patients aged <80 years who were receiving hemodialysis for ESRD and who had undergone successful PCI for angina between January 1999 and December 2004 were included in the analysis. Patients were stratified based on status of nicorandil treatment before PCI, as follows: patients receiving nicorandil 5 mg PO TID (the recommended dosage in Japan) for >1 month before PCI (nicorandil group) or those who did not receive nicorandil (control group). We investigated 6-year follow-up data on the primary end point, defined as CVEs (ie, unplanned hospital admission for worsening anginal status, or CVE-related death). The secondary end point was CVE-related death. After the data were initially analyzed, we performed a propensity-matched analysis to minimize selection bias. RESULTS: Data from 356 patients were included in the study (235 men, 121 women; mean [SD] age, 69 [9] years; mean [SD] weight, 52.3 [9.1] kg; nicorandil group, 198 patients; control group, 158 patients). According to the estimated propensity scores, 107 patients from each group were matched. There were no differences between the 2 groups in the baseline characteristics. On propensity-matched patient analysis, the estimated rates of patients who were CVE-free at 6 years were 3

DOI： 10.1016/j.clinthera.2007.12.020

PubMed

Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity: value of highly expressed hDAF for xenotransplantation. Reviewed

Liu D, Kobayashi T, Onishi A, Furusawa T, Iwamoto M, Suzuki S, Miwa Y, Nagasaka T, Maruyama S, Kadomatsu K, Uchida K, Nakao A.

Xenotransplantation. Vol. 14 ( 1 ) page： 67 - 73 2007.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Although the successful production of alpha1,3-galactosyltransferase-knockout (GT-KO) pigs has increased expectations of clinical xenotransplantation, additional modifications of genetically engineered pigs are still being explored, because even GT-KO pigs are incapable of inhibiting the host's immunological response completely. One of the potential candidates is a complement-regulatory protein, such as human decay-accelerating factor (hDAF). However, there are few reports on how high the expression level of hDAF in pig cells would be required for suppression of complement activation. The purpose of this study was to examine the relationship between the level of hDAF expression and its inhibitory effect on human serum cytotoxicity. METHODS: An expression (pCAGGS) vector containing the hDAF gene was transfected into pig fibroblasts using an electroporation system (Gene Pulser II). Forty-eight to fifty-two hours after transfection, the cells were stained with FITC-labeled anti-hDAF antibody and then applied to the cell sorter. hDAF-transfected cells with various expression levels were collected by gating on fluorescence intensity. The level of hDAF expression was determined relative to that in human control endothelial cells. Collected cells expressing x1, x5, x10, x15 and x30 hDAF were incubated into 96-well plates for 16 h, and the cells were subjected to 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide (MTT) assay. RESULTS: hDAF expression levels in transfected cells at the time of MTT assay (16 h after sorting) were comparable to those immediately after sorting. hDAF expression in pig cells five times higher than in human endothelial cells was effective in inhibiting complement-dependent cytotoxicity of most human sera. However, 15- to 30-fold expression of hDAF was required for effective inhibition of human sera with the highest cytotoxic capacity. CONCLUSIONS: A much higher level of hDAF expression in pig cells than previously considered

DOI： 10.1111/j.1399-3089.2006.00365.x

PubMed

Effects of olprinone, a phosphodiesterase III inhibitor, on ischemic acute renal failure. Reviewed

Anas C, Ozaki T, Maruyama S, Yamamoto T, Gotoh M, Ono Y, Matsuo S

International journal of Urology Vol. 14 ( 3 ) page： 219 - 225 2007

Comparison of percutaneous coronary intervention with medication in the treatment of coronary artery disease in hemodialysis patients. Reviewed

Yasuda K, Kasuga H, Aoyama T, Takahashi H, Toriyama T, Kawade Y, Iwashima S, Yamada S, Kawahara H, Maruyama S, Yuzawa Y, Ishii H, Murohara T, Matsuo S

Journal of the American Society of Nephrology Vol. 17 ( 8 ) page： 2322 - 2332 2006.8

Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70. Reviewed

Suzuki S, Maruyama S, Sato W, Morita Y, Sato F, Miki Y, Kato S, Katsuno M, Sobue G, Yuzawa Y, Matsuo S

Kidney international Vol. 67 ( 6 ) page： 2210 - 2220 2005.6

Caveolin-1 in mesangial cells suppresses MAP kinase activation and cell proliferation induced by bFGF and PDGF. Reviewed

Fujita Y, Maruyama S, Kogo H, Matsuo S, Fujimoto T

Kidney international Vol. 66 ( 5 ) page： 1794 - 1804 2004.11

In vivo gene transfer of endo-beta-galactosidase C removes alphaGal antigen on erythrocytes and endothelial cells of the organs. Reviewed

Miki Y, Maruyama S, Liu D, Kobayashi T, Sato F, Shimizu H, Kato S, Sato W, Morita Y, Yuzawa Y, Muramatsu T, Matsuo S.

Xenotransplantation. Vol. 11 ( 5 ) page： 444 - 451 2004.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The presence of Galalpha1-3Galbeta1-4GlcNAc (alphaGal) in pigs is a formidable barrier for pig-to-primate xenotransplantation. We have reported that administration of recombinant endo-beta-galactosidase C (EndoGalC) removes alphaGal on porcine erythrocytes and kidneys. The present study examined the effects of EndoGalC gene therapy on alphaGal suppression. METHODS: Naked plasmid DNA encoding Igkappa-EndoGalC was given to rats by rapid tail vein injection. The expression of alphaGal in the heart and kidney were studied by lectin staining followed by computer-assisted quantitative analyses. alphaGal expression on erythrocytes was determined by flow cytometric analyses. Enzymatic activity of EndoGalC in the serum was also determined by evaluating the capacity of EndoGalC in removing alphaGal epitopes. Elimination of alphaGal was further studied by injecting antibodies against alphaGal to rats 2 days after the gene transfer. RESULTS: Administration of 1 mg of Igkappa-EndoGalC/pCAGGS plasmid eliminated alphaGal from the vascular endothelium of the heart and kidney on day 1 and day 2. Between days 4 and 7, alphaGal started to reappear, but remained suppressed. No serious adverse effect was observed in rats treated with EndoGalC. Flow cytometric analyses showed that EndoGalC digested 97% of alphaGal on erythrocytes when measured 4 days after the gene transfer. Enzymatic activity of EndoGalC in the serum peaked on day 1, and significant levels were still observed on day 7. When antibodies against alphaGal were given, rats treated with EndoGalC showed no change, while all control rats died within 40 min. CONCLUSIONS: The present study demonstrates the potential of an EndoGalC gene transfer, using a hydrodynamics-based delivery system, in eliminating alphaGal from endothelial cells in vivo. The results also ensured that EndoGalC is not harmful suggesting that the production of pigs overexpressing EndoGalC would be a reasonable alternative to pigs deficient in alph

DOI： 10.1111/j.1399-3089.2004.00163.x

PubMed

Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4. Reviewed

Kato S, Yuzawa Y, Tsuboi N, Maruyama S, Morita Y, Matsuguchi T, Matsuo S.

J Am Soc Nephrol. Vol. 15 ( 5 ) page： 1289 - 1299 2004.5

Language：English Publishing type：Research paper (scientific journal)

Acute peritonitis, in which peritoneal mesothelial cells are directly exposed to bacterial components, is a major cause of peritoneal dysfunction in continuous ambulatory peritoneal dialysis patients. We have previously shown that Toll-like receptors (TLR) are expressed in kidney cells, and LPS induces TLR4-dependent chemokine production in tubular epithelial cells. The present work was designed to investigate the involvement of TLR, especially TLR4, in the lipid A-mediated chemokine production by murine peritoneal mesothelial cells (MPMC). A primary cell culture of MPMC from C3H/HeN mice (wild-type mice; LPS sensitive) and from C3H/HeJ mice (containing a point mutation of TLR4; LPS hyposensitive) was established. The expression profile of the TLR family and their accessory molecules, CD14 and MD-2, which are requisite for the LPS signaling pathway, was examined by RT-PCR, Northern blot test, and immunohistochemical staining. Synthetic lipid A-mediated chemokine production by MPMC was studied. The involvement of MAP kinase family (ERK, JNK, and p38 mitogen-activated protein kinase) and nuclear factor (NF)-kappaB in these processes was also studied. MPMC constitutively express TLR4, CD14, and MD-2. A prominent induction of monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein (MIP)-2 by MPMC was detected after lipid A stimulation and was strictly dependent on TLR4. Furthermore, TLR4-dependent chemokine production followed by leukocyte influx into the peritoneal cavity was also confirmed in vivo after stimulation with LPS. mRNA expression of MCP-1 was abolished by NF-kappaB inhibition, but were not affected by the inhibition of ERK, JNK, or p38. As compared with MCP-1, MIP-2 mRNA expression was inhibited by a high dose of curcumin but not by NF-kappaB decoy oligodeoxynucleotide and individual inhibitions of MAP kinase, suggesting that the additional signaling pathway with NF-kappaB might be involved in mRNA expression of MIP-2. These show that TLR

PubMed

The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. Reviewed

Liu MC, Maruyama S, Mizuno M, Morita Y, Hanaki S, Yuzawa Y, Matsuo S.

Clin Exp Nephrol. Vol. 7 ( 3 ) page： 186 - 194 2003.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Although Aristolochia manshuriensis (AM), which was incriminated in the Japanese variety of Chinese herbs nephropathy, has been recently shown to be nephrotoxic in rats, less is known about whether this toxicity is attributable to its aristolochic acids (AA). We compared the renal effect of AM with that of Akebia quinata (AQ), which has similar components to AM but is free of AA; we also compared this effect of AM with that of pure AA, and studied its possible mechanism. METHODS: In study 1, rats were divided into four groups. Each group was orally given either 0.4 g of AM, 4 g of AM, or 4 g of AQ per day, or vehicle, for 5 days. In study 2, rats were given 4 g of AM (which contained 4 mg of AA), or 4 mg of pure AA per day, or vehicle, for 5 days. Renal function, and renal histology were evaluated on day 5 in study 1 and on days 1, 3, 5, and 14 in study 2. In study 2, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) and proliferating cell nuclear antigen (PCNA) staining were also performed. In study 3, rats were treated in the same way as in study 2, but were all killed on day 5. Concentrations of AA (I + II) were measured in serum and urine in study 2, and in the kidney, lung, heart, liver, and spleen in study 3. RESULTS: In study 1, only the rats that received 4 g/day of AM developed tubular necrosis, azotemia, proteinuria, and glucosuria. In study 2, both AM- and AA-treated rats showed progressive tubular damage, decreased renal function, and increased urinary protein excretion. The degree of these alterations was comparable in the AM and AA groups. Moreover, the concentrations of AA (I + II), in serum, urine, and kidney were also comparable in the AM- and AA-treated rats. High levels of AA were detected in the lung and kidney. Apoptotic tubular cells increased on day 5 and had decreased by day 14 after the withdrawal of AM or AA. Meanwhile, proliferating tubular cells progressively increased from day 3 to day 14. C

DOI： 10.1007/s10157-003-0229-z

PubMed

Non-dipping is a potent predictor of cardiovascular mortality and is associated with autonomic dysfunction in haemodialysis patients. Reviewed

Liu M, Takahashi H, Morita Y, Maruyama S, Mizuno M, Yuzawa Y, Watanabe M, Toriyama T, Kawahara H, Matsuo S.

Nephrol Dial Transplant. Vol. 18 ( 3 ) page： 563 - 569 2003.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Lack of nocturnal blood pressure (BP) fall (non-dipping) is common among haemodialysis (HD) patients, but much less is known regarding its association with cardiovascular (CV) disease morbidity and mortality. METHODS: Eighty HD patients initially underwent 24 h ambulatory BP monitoring (ABPM), and then they were defined as either 'dippers' (n=24, nocturnal BP fall > or = 10%) or 'non-dippers' (n=56, fall <10%). Coronary angiography was performed in the patients who had signs and/or symptoms of coronary artery disease (CAD). Twenty-four hour ambulatory ECG was recorded in 20 dippers and 20 non-dipper HD patients, and in 20 normal subjects. All patients were followed for up to 5.8 years (33.0+/-19.1 months). The outcome events studied were the hospitalisations due to CV diseases and CV death. RESULTS: Compared with dippers, non-dippers initially had a higher incidence of coronary artery stenosis (P<0.05) along with left ventricular asynergy (both Ps<0.01). The circadian rhythm of autonomic function was impaired in non-dippers. The incidences of CV events and CV deaths were 3.5 and 9 times higher in non-dippers than in dippers. The cumulative CV event-free survival and CV survival rates were lower in non-dippers than in dippers (P=0.02 and P=0.005, respectively). Based on Cox analysis, non-dipping was associated positively with CV events and CV mortality [hazard ratio (HR) 2.46, 95% CI 1.02-5.92, P=0.038 and HR 9.62, 95% CI 1.23-75.42, P=0.031, respectively]. Meanwhile, nocturnal systolic BP fall, diurnal systolic BP and diurnal pulse pressure were negatively associated with CV event/death. The clinic BP was not associated with CV event/death. CONCLUSIONS: The non-dipping phenomenon is closely related to a high incidence of CV diseases, a poor long-term survival and profound autonomic dysfunction. ABPM is useful in predicting long-term CV prognosis in HD patients.

DOI： 10.1093/ndt/18.3.563

PubMed

Proteinuria and tubulointerstitial injury: the causative factors for the progression of renal diseases. Reviewed

Matsuo S, Morita Y, Maruyama S, Manchang L, Yuzawa Y.

Contrib Nephrol. Vol. 139 page： 20 - 31 2003

P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction. Reviewed

Naruse T, Yuzawa Y, Akahori T, Mizuno M, Maruyama S, Kannagi R, Hotta N, Matsuo S.

Kidney Int. Vol. 62 ( 1 ) page： 94 - 105 2002.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Interstitial infiltration of macrophages (Mø) is one of the main causal factors for the tubulointerstitial injury. However, precise mechanisms of Mø infiltration into tubulointerstitium have not been fully explored. The purposes of this study were to assess the role of selectins in the acute infiltration of Mø in rats with unilateral ureteral obstruction (UUO) and to evaluate the role of vasa recta, that is, whether they facilitate massive influx of Mø into the interstitium by functioning as specialized vessels. METHODS: To evaluate the role of selectins in Mø infiltration into tubulointerstitium, the expression of selectins and L-selectin ligands was examined by immunohistochemistry and immunoelectron microscopy. The functional role of P-selectin in vasa recta was studied by Stamper-Woodruff assay, in vivo p-Mø migration assay and in vivo blocking experiments with the monoclonal antibody (mAb) ARP2-4. RESULTS: Selective expression of P-selectin was detected in vasa recta as early as one hour after UUO, and the expression increased thereafter for 96 hours. In contrast, endothelial expression of L-selectin ligands and E-selectin were not detectable. In the Stamper-Woodruff assay on kidney sections of rats with UUO, the adhesion of isolated rat peritoneal Mø (p-Mø) to vasa recta was significantly inhibited by the mAb ARP2-4 (P-selectin blocker; P < 0.01), but not by mAb ARE-5 (E-selectin blocker) or rLECIg (rat L-selectin chimeric protein). In the in vivo transfer experiments with fluorescein-labeled p-Mø into rats 48 hours after UUO, labeled p-Mø had accumulated around vasa recta at three minutes and had infiltrated predominantly into the outer medulla at 180 minutes. The number of labeled p-Mø was reduced when the rats were pretreated with ARP2-4 (P < 0.01). Finally, ARP2-4 (10 mg/kg), injected 15 minutes before UUO, reduced the number of infiltrated Mø (P < 0.01). CONCLU

DOI： 10.1046/j.1523-1755.2002.00419.x

PubMed

Effects of human soluble thrombomodulin on experimental glomerulonephritis. Reviewed

Ikeguchi H, Maruyama S, Morita Y, Fujita Y, Kato T, Natori Y, Akatsu H, Campbell W, Okada N, Okada H, Yuzawa Y, Matsuo S.

Kidney Int. Vol. 61 ( 2 ) page： 490 - 501 2002.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Coagulation and inflammation are both important processes that contribute to glomerular injury. The present study was performed to evaluate the effects of recombinant human soluble thrombomodulin (RHS-TM) in a lethal model of thrombotic glomerulonephritis and to investigate the possible mechanisms. METHODS: Thrombotic glomerulonephritis was induced in rats by administration of lipopolysaccharide and rabbit anti-rat glomerular basement membrane antibody. One hour later, RHS-TM or heparin was administered, and the histological findings, renal functions, and coagulation parameters were evaluated. To evaluate the contribution of carboxypeptidase R (CPR) to the results obtained in rats treated with RHS-TM, plasma CPR levels were measured. Then, carboxypeptidase inhibitor (CPI), which prevents the function of CPR, was administered. RESULTS: Massive glomerular thrombosis and lung hemorrhage developed within five hours of disease induction, and all rats died within 24 hours. RHS-TM (3 mg/kg) prevented the progression of the disease and all rats survived. Heparin (250 U/kg/h) showed similar anti-thrombotic effect, but induced massive hemorrhage in the lungs or stomach. RHS-TM attenuated leukocyte/neutrophil infiltration in the glomerulus but heparin did not, suggesting that RHS-TM has anti-inflammatory properties. CPR levels in plasma were about threefold higher in rats treated with RHS-TM compared to those in rats treated with heparin. Furthermore, the inhibitory effect of RHS-TM on leukocyte/neutrophil infiltration was significantly diminished by injection of CPI. CONCLUSION: RHS-TM effectively attenuates the injuries of thrombotic glomerulonephritis in rats. The results indicate that RHS-TM, in addition to its anti-thrombotic action, may exert its anti-inflammatory properties by converting proCPR to CPR, which then inactivates anaphylatoxins. RHS-TM is a potential novel therapeutic tool for thrombotic glomerular injury and related disorders.

DOI： 10.1046/j.1523-1755.2002.00160.x

PubMed

Membranous glomerulopathy with Bowman's capsular and tubular basement membrane deposits. Reviewed

Markowitz GS, Kambham N, Maruyama S, Appel GB, Cohen DJ, Kim RC, Andres GA, D'Agati VD.

Clin Nephrol. Vol. 54 ( 6 ) page： 478 - 486 2000.12

Language：English Publishing type：Research paper (scientific journal)

Bowman's capsular and tubular basement membrane (TBM) deposits are an extremely unusual finding in non-lupus membranous glomerulopathy (MGN). We report three atypical cases of MGN with abundant Bowman's capsular and TBM deposits. In two cases, MGN was idiopathic; in the third case, MGN occurred in the renal allograft in the setting of HCV seropositivity. In addition to the usual glomerular capillary wall deposits, immunofluorescence and electron microscopy revealed extensive immune deposits within Bowman's capsule and TBMs, predominantly at the base of parietal and tubular epithelial cells. These cases suggest a potential pathomechanism of autoantibody to secreted epithelial antigens shared by visceral, parietal, and tubular epithelial cells. In all three cases, indirect immunofluorescence was unable to detect autoantibody to normal renal epithelial or matrix constituents. Furthermore, ELISA was unable to demonstrate circulating antibody to major extracellular matrix components. The implications of these findings for the pathogenesis of MGN are explored.

PubMed

Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. Reviewed

Biancone L, Cantaluppi V, Segoloni G, Boccellino M, Del Sorbo L, Conaldi PG, Tjoelker LW, Maruyama S, Cantu E, Stern D, Andres G, Camussi G.

Transplantation. Vol. 70 ( 8 ) page： 1198 - 1205 2000.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Platelet-activating factor (PAF) is a phospholipid mediator of inflammation which has been implicated in rejection. The interaction of anti-alpha-galactosyl natural antibodies (anti-alpha gal Abs) with endothelial cells is the initial step for the development of xenograft rejection. In our study, we stimulated porcine aortic endothelial cells (PAEC) with anti-alpha gal IgG to investigate the synthesis of PAF from PAEC and its biological consequences. METHODS AND RESULTS: PAF was extracted and chromatographically purified from cultured PAEC stimulated with baboon anti-alpha gal Abs. The Abs induced a dose-dependent synthesis of PAF peaking after 30 min of incubation, and decreasing thereafter. Concomitant cell shape change, motility, and cytoskeleton redistribution were observed. These events were prevented by addition of a panel of PAF-receptor antagonists. An SV40 T-large antigen-immortalized PAEC line was engineered to express PAF acetyl-hydrolase (PAF-AH) cDNA, the major PAF-inactivating enzyme. These transfected cells exposed to anti-alpha gal Abs showed reduced cell contraction and motility compared with empty vector-transfected cells. Moreover, in PAEC stimulated with anti-alpha gal Abs, the synthesis of PAF promoted the adhesion of a monocytic cell line as shown by the inhibitory effect of PAF-receptor antagonists and of PAF-AH expression. Finally, studies on cell monolayer demonstrated an enhanced permeability 48 hr after exposure to anti-alpha gal Abs, and this increase was prevented by PAF-inactivation and by PAF-receptor blockade. CONCLUSIONS: These results demonstrate that on stimulation with anti-alpha gal Abs, PAEC synthetize PAF which can contribute to several vascular events involved in xenograft rejection.

DOI： 10.1097/00007890-200010270-00013

PubMed

alpha-galactosyl epitopes on glycoproteins of porcine renal extracellular matrix. Reviewed

Maruyama S, Cantu E 3rd, Galili U, D'Agati V, Godman G, Stern DM, Andres G

Kidney Int. Vol. 57 ( 2 ) page： 655 - 663 2000.2

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The pig is the donor animal of choice for human xenotransplantation. In the most relevant pig-to-baboon model, pig organs transplanted into baboons are hyperacutely rejected by natural xenoantibodies, which mainly bind to alpha-galactosyl (alphaGal) epitopes expressed at the surface of endothelial cells. Recent advances in controlling hyperacute rejection have led to improved survival of these xenografts, and it is now important to identify alphaGal binding sites in other cells and tissues that may be subject to immunologic attack. To this end, we have studied whether alphaGal antibodies bind to glycated proteins of the extracellular matrix in the kidney and other organs most likely to be used for human xenotransplantation. METHODS: High-titer anti-alphaGal antibodies, similar to human natural xenoantibodies, were prepared in baboons, and their reactivity with components of pig extracellular matrix was tested by serology and immunohistology. RESULTS: The antibodies recognized epitopes of immobilized murine, bovine or porcine thyroglobulin, laminin, heparan sulfate proteoglycans, and fibronectin. In sections of pig tissue, the antibodies bound to endothelial and certain epithelial cells, as shown in previous studies, and also to mesenchymal cells, basement membranes, and extracellular matrices, in which they colocalized with matrix glycoproteins, especially laminin and heparan sulfate proteoglycans. CONCLUSIONS: These results suggest that when pig xenografts can be made to survive for prolonged periods, the reactivity of alphaGal antibody with matrix molecules can induce basement membrane and matrix lesions similar to those induced in laboratory animals by antilaminin and antiheparan sulfate proteoglycans antibodies.

DOI： 10.1046/j.1523-1755.2000.00887.x

PubMed

Differential expression of alpha-GAL epitopes (Galalpha1-3Galbeta1-4GlcNAc-R) on pig and mouse organs. Reviewed

Tanemura M, Maruyama S, Galili U

Transplantation. Vol. 69 ( 1 ) page： 187 - 190 2000.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Expression of the alpha-gal epitope in mice can be completely eliminated by disruption of the alpha1,3 galactosyltransferase gene. As an initial step for assessing the feasibility of this approach in the pig, it was of interest to compare the expression of alpha-gal epitopes in pig and mouse organs. METHODS: Membranes from pig and mouse organ homogenates were analyzed for alpha-gal epitope expression by Western blots, enzyme-linked immunosorbent assay (ELISA), immunostaining of tissues, and ELISA inhibition assay. RESULTS: Immunostaining of Western blots with human anti-Gal detected alpha-gal epitopes on glycoproteins from pig organs but not on glycoproteins from the corresponding mouse organs. ELISA with membrane homogenates and immunostaining of tissue sections demonstrated a much higher binding of human anti-Gal to alpha-gal epitopes on pig membranes than on mouse membranes. ELISA inhibition assay with monoclonal anti-Gal indicated that alpha-gal epitope expression in pig organs is up to 500-fold higher than in mouse organs. CONCLUSION: Expression of alpha-gal epitopes in pig organs is many fold higher than in mouse organs. The abundance of these epitopes in pigs raises the question of whether pigs can properly develop without expression of alpha-gal epitopes.

DOI： 10.1097/00007890-200001150-00034

PubMed

Interaction of baboon anti-alpha-galactosyl antibody with pig tissues. Reviewed

Maruyama S, Cantu E 3rd, DeMartino C, Wang CY, Chen J, Al-Mohanna F, NakeebSM, D'Agati V, Pernis B, Galili U, Godman G, Stern DM, Andres G

Am J Pathol. Vol. 155 ( 5 ) page： 1635 - 1649 1999.11

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

As barriers to xenotransplantation are surmounted, such as suppression of hyperacute rejection allowing improved graft survival, it becomes important to define longer-term host-xenograft interactions. To this end we have prepared in baboons high titer anti-alpha-Galactosyl (alphaGal) and anti-porcine aortic endothelial cell antibodies, similar to human natural xenoantibodies and reactive with epitopes of thyroglobulin, laminin, and heparan sulfate proteoglycans. When injected into pigs with a protocol similar to that used in the rat to show the nephritogenic potential of heterologous anti-laminin and anti-heparan sulfate proteoglycan antibodies, baboon immunoglobulins bound first to renal vascular endothelium, and later to interstitial cells, especially fibroblasts and macrophages, and to antigens in basement membranes and extracellular matrix, where they colocalized with laminin- and heparan sulfate proteoglycan-antibodies, and with bound Griffonia simplicifolia B4. A similar binding was observed in other organs. The pigs did not develop an acute complement-dependent inflammation, but rather chronic lesions of the basement membranes and the extracellular matrix. Incubation of renal fibroblasts with baboon anti-alpha-Galactosyl antibodies resulted in increased synthesis of transforming growth factor-beta and collagen, suggesting a possible basis for the fibrotic response. The results demonstrate that in this experimental model a consequence of alphaGal antibody interaction with porcine tissues, is immunoreactivity with alphaGal on matrix molecules and interstitial cells, priming mechanisms leading to fibrosis resembling that in chronic allograft rejection. The possibility that similar lesions may develop in long-surviving pig xenografts is discussed.

DOI： 10.1016/s0002-9440(10)65479-x.

PubMed

Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme: considerations on its relevance to the pathogenesis of human idiopathic membranous glomerulonephritis. Reviewed

Maruyama S, Cantu E 3rd, Demartino C, Vladutiu A, Caldwell PR, Wang CY,D'Agati V, Godman G, Stern DM, Andres G

J Am Soc Nephrol. Vol. 10 ( 10 ) page： 2102 - 2108 1999.10

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

In the course of studies on the humoral consequences of swine to primate xenotransplantation, the investigators induced formation of glomerular subepithelial immune deposits and tubular lesions in pigs injected with heterologous antibody to angiotensin-converting enzyme. This study describes the morphology of the lesions, discusses their mechanism, explains their relevance for understanding the pathogenesis of human idiopathic membranous glomerulonephritis, and proposes future directions for investigations.

DOI： 10.1681/ASN.V10102102

PubMed

Alpha-galactosyl antibody redistributes alpha-galactosyl at the surface of pig blood and endothelial cells. Reviewed

Maruyama S, Cantu E3rd, Pernis B, Galili U, Godman G, Stern DM, Andres G

Transpl Immunol. Vol. 7 ( 2 ) page： 101 - 106 1999.6

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

The interaction of antibodies with cell surface antigens may induce redistribution of immune complexes, followed by antigen depletion, with increased resistance to injurious effect of antibody and complement (antigenic modulation). Human natural antibodies to Gal alpha 1,3Gal beta 1,4GlcNAc-R (alpha Gal) epitopes expressed at the surface of pig cells are a major obstacle to xenotransplantation. Recent studies have shown that these antibodies do not modulate alpha Gal, but the morphological consequences of the antigen-antibody interaction are unknown. Pig blood and endothelial cells, were exposed to baboon alpha-Gal antibodies, and studied by immunofluorescence and phase contrast microscopy, flow cytometry, and inhibition enzyme-linked immunosorbent assay. In cells studied at 4 degrees C or fixed, alpha Gal was diffusely expressed at the surface. After cross-linking at 37 degrees C, antigenic modulation did not occur, but granular redistribution of alpha Gal immune complexes was seen in all cell types. In other systems a similar redistribution is known to induce perturbation of the plasma membrane/cytoskeletal structure with changes in adhesive properties, gene regulation, and T cell activation, which could be important if pig xenografts will be made to survive for prolonged periods.

DOI： 10.1016/s0966-3274(99)80026-4

PubMed

Role of complement in acute tubulointerstitial injury of rats with aminonucleoside nephrosis. Reviewed

Nomura A, Morita Y, Maruyama S, Hotta N, Nadai M, Wang L, Hasegawa T, Matsuo S

Am J Pathol. Vol. 151 ( 2 ) page： 539 - 547 1997.8

Language：English Publishing type：Research paper (scientific journal)

The present work was designed to elucidate the in vivo role of complement in the proteinuria-associated tubulointerstitial injury. Rats were intravenously injected with puromycin aminonucleoside, and massive proteinuria was observed within 5 days. Prominent tubulointerstitial injury characterized by proximal tubular degeneration, tubular dilatation, and leukocyte infiltration were observed 7 days after injection. C3 and C5b-9 were observed in the luminal side of proximal tubular cells. Renal function, assessed by inulin and para-aminohippurate clearance, was significantly decreased. To-assess the role of complement in this model, rats were injected with either cobra venom factor or soluble recombinant human complement receptor type 1 starting at day 3. These manipulations significantly improved tubulointerstitial pathology and para-aminohippurate clearance without affecting the degree of proteinuria. Deposition of C3 and C5b-9 was not detected in the kidney of rats depleted of complement by cobra venom factor. In rats treated with soluble complement receptor, C3 was still detected in the tubules, but deposition of C5b-9 was not observed. Soluble complement receptor was detected at the site of C3 deposition and in the urine. These data strongly suggest that complement plays a pivotal role in proteinuria-associated tubulointerstitial injury and that systemic complement depletion or inhibition of complement in the tubular lumen may diminish the tubulointerstitial damage.

PubMed

Detection of ret homodimers in MEN 2A-associated pheochromocytomas. Reviewed

Wada M, Asai N, Tsuzuki T, Maruyama S, Ohiwa M, Imai T, Funahashi H, Takagi H, Takahashi M

Biochem Biophys Res Commun Vol. 218 ( 2 ) page： 606 - 609 1996.1

Language：English Publishing type：Research paper (scientific journal)

Using transfection of NIH 3T3 cells, we have recently demonstrated that multiple endocrine neoplasia (MEN) 2A mutations activate the c-Ret protein by inducing its disulfide-linked homodimerization on the cell surface. To investigate whether the homodimers are present in original tumors, the expression of the c-Ret protein was analyzed in eight sporadic and two MEN 2A-associated pheochromocytomas, the latter two of which contained mutations in cysteine 618 or 634 of Ret. The c-Ret protein was expressed at variable levels in all pheochromocytomas examined. By labeling the c-Ret protein immunoprecipitated from tumor tissues with [gamma-32P]ATP in vitro, its homodimers were detected in pheochromocytomas from MEN 2A patients but not in a sporadic tumor. This result represents the first demonstration of Ret homodimers in original tumors.

DOI： 10.1006/bbrc.1996.0107

PubMed

Germ line mutations of the ret proto-oncogene in Japanese patients with multiple endocrine neoplasia type 2A and type 2B. Reviewed

Maruyama S, Iwashita T, Imai T, Funahashi H, Ceccherini I, Luo Y, Romeo G, Matsuo S, Matsuyama M, Takahashi M

Jpn J Cancer Res Vol. 85 ( 9 ) page： 879 - 882 1994.9

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

We investigated mutations of the ret proto-oncogene in Japanese patients with multiple endocrine neoplasia (MEN) type 2A and type 2B. DNAs from pheochromocytomas and/or medullary thyroid carcinomas (MTCs) of five MEN 2A and three MEN 2B patients were amplified by a polymerase chain reaction (PCR) and analyzed. Tumors of four MEN 2A patients had missense mutations in Cys 634 in the extracellular domain of the ret proto-oncogene. The same mutations were detected in normal tissues of the patients, indicating that the mutations had arisen in the germ line. Using a reverse transcriptase(RT)-PCR, both normal and mutant transcripts of the ret proto-oncogene were detected in a tumor of one patient with MEN 2A mutation. In addition, three MEN 2B patients examined had the same point mutation (ATG-->ACG) at codon 918 in the tyrosine kinase domain of the ret proto-oncogene. Since all mutations identified in this study generated new restriction enzyme sites or eliminated a restriction site, the mutant alleles of affected family members could be readily detected without sequencing.

DOI： 10.1111/j.1349-7006.1994.tb02962.x

PubMed

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