Updated on 2024/03/20

写真a

 
KOTANI, Tomomi
 
Organization
Nagoya University Hospital Maternity and Perinatal Care Center Professor of hospital
Title
Professor of hospital
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 2002.3   名古屋大学 ) 

Research Interests 6

  1. preterm delovary

  2. preeclampsia

  3. invsion of trophoblast

  4. fetal development

  5. perinatal brain damage

  6. perinatal mental health

Research Areas 1

  1. Others / Others  / perinatology

Current Research Project and SDGs 4

  1. 胎内炎症曝露が及ぼすエピジェネティック変化とその制御

  2. 妊産婦前向きコホート研究の成果を用いた要介入群の同定法と支援策の開発

  3. 新規自己抗体標的抗原に着目した自己免疫関連生殖機能障害の病態解明と早期診断法確立

  4. Maternal-fetal boundary surface environment strategy

Research History 1

  1. Nagoya University   Nagoya University Hospital Maternity and Perinatal Care Center   Associate professor

    2018.7

Education 1

  1. Nagoya University   Graduate School, Division of Medicine

    1999.4 - 2002.3

      More details

    Country: Japan

Professional Memberships 1

  1. 日本産婦人科学会、日本周産期.新生児学会、日本胎盤学会、日本人類遺伝学会、日本内分泌学会

    2006.4 - 2010.3

Committee Memberships 1

  1. 産婦人科診療ガイドライン委員会   委員  

    2014.4 - 2017.3   

 

Papers 156

  1. Postpartum and interpregnancy care of women with a history of hypertensive disorders of pregnancy. Reviewed

    Ushida T, Tano S, Imai K, Matsuo S, Kajiyama H, Kotani T

    Hypertension research : official journal of the Japanese Society of Hypertension     2024.3

     More details

    Authorship:Last author   Language:English  

    DOI: 10.1038/s41440-024-01641-7

    PubMed

  2. Predicting preterm birth within 2 weeks in asymptomatic women with a short cervix: Combined effects of cervicovaginal fluid cytokine levels and fetal fibronectin test Reviewed

    Ohori, Y; Imai, K; Tano, S; Owaki, T; Miki, R; Nozaki, Y; Ushida, T; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH     2024.1

     More details

    Authorship:Last author   Language:English  

    DOI: 10.1111/jog.15889

    Web of Science

    PubMed

  3. Antenatal prediction models for outcomes of extremely and very preterm infants based on machine learning. Reviewed

    Ushida T, Kotani T, Baba J, Imai K, Moriyama Y, Nakano-Kobayashi T, Iitani Y, Nakamura N, Hayakawa M, Kajiyama H, Neonatal Research Network of Japan

    Archives of gynecology and obstetrics   Vol. 308 ( 6 ) page: 1755 - 1763   2023.12

     More details

  4. New-onset postpartum hypertension in women without a history of hypertensive disorders of pregnancy: a multicenter study in Japan Reviewed

    Ushida, T; Nakamura, N; Katsuki, S; Mizutani, H; Iitani, Y; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    HYPERTENSION RESEARCH   Vol. 46 ( 12 ) page: 2583 - 2592   2023.12

     More details

    Authorship:Last author   Language:English  

    DOI: 10.1038/s41440-023-01372-1

    Web of Science

    PubMed

  5. Sex-specific differences in head circumference of term singletons after assisted reproductive technology: a multicentre study in Japan Reviewed

    Matsuo, S; Ushida, T; Tano, S; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    REPRODUCTIVE BIOMEDICINE ONLINE   Vol. 47 ( 6 ) page: 103331   2023.12

     More details

    Authorship:Last author   Language:English  

    DOI: 10.1016/j.rbmo.2023.103331

    Web of Science

    PubMed

  6. Predictive performance of Shock Index for postpartum hemorrhage during cesarean delivery. Reviewed

    Mizutani H, Ushida T, Ozeki K, Tano S, Iitani Y, Imai K, Nishiwaki K, Kajiyama H, Kotani T

    International journal of obstetric anesthesia     page: 103957   2023.11

     More details

    Authorship:Last author   Language:English  

    DOI: 10.1016/j.ijoa.2023.103957

    PubMed

  7. Long-term effects of gestational weight gain on mortality Invited

    Kotani, T; Tano, S

    LANCET   Vol. 402 ( 10415 ) page: 1809 - 1811   2023.11

     More details

    Authorship:Lead author, Corresponding author   Language:English  

    DOI: 10.1016/S0140-6736(23)01837-8

    Web of Science

    PubMed

  8. Antenatal corticosteroids and outcomes of small for gestational age infants born at 24-31 gestational weeks: a population-based propensity score matching analysis Reviewed

    Ushida, T; Nakatochi, M; Kobayashi, Y; Nakamura, N; Fuma, K; Iitani, Y; Imai, K; Sato, Y; Hayakawa, M; Kajiyama, H; Kotani, T; Japan, NRNO

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 308 ( 5 ) page: 1463 - 1471   2023.11

     More details

    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00404-022-06834-4

    Web of Science

    PubMed

  9. Interleukin-17A stimulation induces alterations in Microglial microRNA expression profiles Reviewed

    Iitani, Y; Miki, R; Imai, K; Fuma, K; Ushida, T; Tano, S; Yoshida, K; Yokoi, A; Kajiyama, H; Kotani, T

    PEDIATRIC RESEARCH   Vol. 95 ( 1 ) page: 167 - 173   2023.9

     More details

    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41390-023-02825-6

    Web of Science

    PubMed

  10. Comparison of the efficacy between controlled-release dinoprostone delivery system (PROPESS) and Cook's double balloon catheter plus oxytocin: A retrospective single-center study in Japan Reviewed

    Imai, K; Nozaki, Y; Ushida, T; Tano, S; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 9 ) page: 2317 - 2323   2023.9

     More details

    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15734

    Web of Science

    PubMed

  11. The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset Reviewed

    Yoshihara, M; Mizutani, S; Matsumoto, K; Kato, Y; Masuo, Y; Harumasa, A; Iyoshi, S; Tano, S; Mizutani, H; Kotani, T; Mizutani, E; Shibata, K; Kajiyama, H

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X   Vol. 19   page: 100210   2023.9

     More details

  12. Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model Reviewed

    Nakamura, N; Ushida, T; Onoda, A; Ueda, K; Miura, R; Suzuki, T; Katsuki, S; Mizutani, H; Yoshida, K; Tano, S; Iitani, Y; Imai, K; Hayakawa, M; Kajiyama, H; Sato, Y; Kotani, T

    FRONTIERS IN PEDIATRICS   Vol. 11   page: 1168173   2023.7

     More details

    Authorship:Last author   Language:English  

    DOI: 10.3389/fped.2023.1168173

    Web of Science

    PubMed

  13. Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study Reviewed

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakamura, N; Iitani, Y; Moriyama, Y; Emoto, R; Kato, S; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Matsui, S; Kajiyama, H

    DIABETOLOGY & METABOLIC SYNDROME   Vol. 15 ( 1 ) page: 123   2023.6

     More details

    Authorship:Corresponding author   Language:English  

    DOI: 10.1186/s13098-023-01103-z

    Web of Science

    PubMed

  14. Intrauterine exposure to chorioamnionitis and neuroanatomical alterations at term-equivalent age in preterm infants Reviewed

    Nosaka, R; Ushida, T; Kidokoro, H; Kawaguchi, M; Shiraki, A; Iitani, Y; Imai, K; Nakamura, N; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS     2023.5

     More details

    Authorship:Last author   Language:English  

    DOI: 10.1007/s00404-023-07064-y

    Web of Science

    PubMed

  15. Clinical significances of Bishop score and vaginal bleeding to controlled-release dinoprostone delivery system (PROPESS) efficacy for cervical ripening: A retrospective single-center study in Japan. Reviewed

    The journal of obstetrics and gynaecology research   Vol. 49 ( 4 ) page: 1154 - 1160   2023.4

     More details

    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15575

    Web of Science

    PubMed

  16. Antenatal corticosteroids-to-delivery interval associates cord blood S100B levels. Reviewed

    The journal of obstetrics and gynaecology research   Vol. 49 ( 4 ) page: 1129 - 1136   2023.4

     More details

    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15582

    Web of Science

    PubMed

  17. Trend changes in age-related body mass index gain after coronavirus disease 2019 pandemic in Japan: a multicenter retrospective cohort study. Reviewed

    Reproductive biology and endocrinology : RB&E   Vol. 21 ( 1 ) page: 7   2023.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12958-023-01061-1

    Web of Science

    PubMed

  18. Prenatal diagnosis of distal 13q deletion syndrome in a fetus with esophageal atresia: a case report and review of the literature. Reviewed

    Journal of medical case reports   Vol. 16 ( 1 ) page: 481   2022.12

     More details

  19. Aberrant inflammation in rat pregnancy leads to cardiometabolic alterations in their offspring and intrauterine growth restriction in the F2 generation Reviewed International coauthorship

    Ushida, T; Cotechini, T; Protopapas, N; Atallah, A; Collyer, C; Toews, AJ; Macdonald-Goodfellow, SK; Tse, MY; Winn, LM; Pang, SC; Adams, MA; Othman, M; Kotani, T; Kajiyama, H; Graham, CH

    JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE   Vol. 13 ( 6 ) page: 706 - 718   2022.12

     More details

  20. A case of non-immune hydrops fetalis with maternal mirror syndrome diagnosed by trio-based exome sequencing: An autopsy case report and literature review. Reviewed

    Molecular genetics and metabolism reports   Vol. 33   page: 100925   2022.12

     More details

  21. Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells Reviewed

    Aoki, C; Imai, K; Mizutani, T; Sugiyama, D; Miki, R; Koya, Y; Kobayashi, T; Ushida, T; Iitani, Y; Nakamura, N; Owaki, T; Nishikawa, H; Toyokuni, S; Kajiyama, H; Kotani, T

    LIFE SCIENCES   Vol. 308   page: 120955   2022.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lfs.2022.120955

    Web of Science

    PubMed

  22. Optimal annual body mass index change for preventing spontaneous preterm birth in a subsequent pregnancy. Reviewed

    Scientific reports   Vol. 12 ( 1 ) page: 17502   2022.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-22495-4

    Web of Science

    PubMed

  23. 5p deletion with congenital diaphragmatic hernia: a case report Reviewed

    Kotani, T; Ushida, T; Nakamura, N; Imai, K; Iitani, Y; Tano, S; Iwagaki, S; Takahashi, Y; Ito, M; Hayakawa, M; Kajiyama, H

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 16 ( 1 ) page: 390   2022.10

     More details

  24. Severe Congenital Diaphragmatic Hernia With Trisomy 9: A Case Report and Review of the Literature

    Fuma, K; Kotani, T; Nakamura, N; Ushida, T; Kajiyama, H

    CUREUS JOURNAL OF MEDICAL SCIENCE   Vol. 14 ( 8 ) page: e28395   2022.8

     More details

  25. Impact of hypertensive disorders of pregnancy on respiratory outcomes in extremely and very preterm infants: A population-based study in Japan Reviewed

    Ushida, T; Nakamura, N; Nakatochi, M; Kobayashi, Y; Sato, Y; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H; Kotani, T

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 29   page: 54 - 60   2022.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.preghy.2022.06.003

    Web of Science

    PubMed

  26. Reassessing the duration of each stage of labor and their relation to postpartum hemorrhage in the current Japanese population Reviewed

    Ushida, T; Matsuo, S; Nakamura, N; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1760 - 1767   2022.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15280

    Web of Science

    PubMed

  27. Machine learning prediction models for postpartum depression: A multicenter study in Japan Reviewed

    Matsuo, S; Ushida, T; Emoto, R; Moriyama, Y; Iitani, Y; Nakamura, N; Imai, K; Nakano-Kobayashi, T; Yoshida, S; Yamashita, M; Matsui, S; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1775 - 1785   2022.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15266

    Web of Science

    PubMed

  28. The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia Reviewed

    Aoki, C; Imai, K; Owaki, T; Kobayashi-Nakano, T; Ushida, T; Iitani, Y; Nakamura, N; Kajiyama, H; Kotani, T

    MEDICINA-LITHUANIA   Vol. 58 ( 6 )   2022.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/medicina58060731

    Web of Science

    PubMed

  29. Intrauterine exposure to hypertensive disorders of pregnancy and postnatal growth in extremely and very preterm infants Reviewed

    Ushida, T; Kotani, T; Nakatochi, M; Kobayashi, Y; Nakamura, N; Imai, K; Iitani, Y; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 28   page: 174 - 179   2022.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.preghy.2022.05.007

    Web of Science

    PubMed

  30. Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb) Reviewed

    Maki, S; Tanaka, H; Takakura, S; Nii, M; Tanaka, K; Ogura, T; Kotera, M; Nishimura, Y; Tamaru, S; Ushida, T; Tanaka, Y; Kikuchi, N; Kinjo, T; Kawamura, H; Takano, M; Nakamura, K; Suga, S; Kasai, M; Yasui, O; Nagao, K; Maegawa, Y; Kotani, T; Endo, M; Yasuhi, I; Aoki, S; Aoki, Y; Yoshida, Y; Nakata, M; Sekizawa, A; Ikeda, T

    BMJ OPEN   Vol. 12 ( 6 ) page: e054925   2022.6

     More details

  31. Prevalence of common aneuploidy in twin pregnancies Reviewed

    Konishi, A; Samura, O; Muromoto, J; Okamoto, Y; Takahashi, H; Kasai, Y; Ichikawa, M; Yamada, N; Kato, N; Sato, H; Hamada, H; Nakanami, N; Machi, M; Ichizuka, K; Sunami, R; Tanaka, T; Yonetani, N; Kamei, Y; Nagamatsu, T; Matsumoto, M; Tairaku, S; Fujiwara, A; Nakamura, H; Harada, T; Watanabe, T; Sasaki, S; Kawaguchi, S; Minami, S; Ogawa, M; Miura, K; Suzumori, N; Kojima, J; Kotani, T; Sasaki, R; Baba, T; Toyofuku, A; Endo, M; Takeshita, N; Taketani, T; Sase, M; Matsubara, K; Hayata, K; Hamada, Y; Egawa, M; Kakinuma, T; Matsushima, S; Kitagawa, M; Shiga, T; Kurashina, R; Hamada, H; Takagi, H; Kondo, A; Miharu, N; Yamashita, M; Horiya, M; Morimoto, K; Takahashi, K; Okamoto, A; Sekizawa, A; Sago, H

    JOURNAL OF HUMAN GENETICS   Vol. 67 ( 5 ) page: 261 - 265   2022.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s10038-021-01001-0

    Web of Science

    PubMed

  32. Pregnancy Outcomes in Women with Thyroid Diseases Reviewed

    Kotani, T; Imai, K; Ushida, T; Moriyama, Y; Nakano-Kobayashi, T; Osuka, S; Tsuda, H; Sumigama, S; Yamamoto, E; Kinoshita, F; Hirakawa, A; Iwase, A; Kikkawa, F; Kajiyama, H

    JMA JOURNAL   Vol. 5 ( 2 ) page: 216 - 223   2022.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.31662/jmaj.2021-0191

    Web of Science

    PubMed

  33. Assessment of placental abruption with diffusion-weighted imaging Reviewed

    Mizutani, T; Kotani, T; Kato, N; Imai, K; Ushida, T; Nakano-Kobayashi, T; Kinoshita, Y; Ito, M; Kinoshita, F; Yamamuro, O; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 4 ) page: 930 - 937   2022.4

     More details

  34. Crosstalk between foetal vasoactive peptide hormones and placental aminopeptidases regulates placental blood flow: Its significance in preeclampsia Reviewed

    Yoshihara, M; Mizutani, S; Matsumoto, K; Kato, Y; Masuo, Y; Tano, S; Mizutani, H; Kotani, T; Mizutani, E; Shibata, K; Kajiyama, H

    PLACENTA   Vol. 121   page: 32 - 39   2022.4

     More details

  35. Annual Body Mass Index Gain and Risk of Gestational Diabetes Mellitus in a Subsequent Pregnancy

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Iitani, Y; Kinoshita, F; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    FRONTIERS IN ENDOCRINOLOGY   Vol. 13   page: 815390   2022.3

     More details

  36. Effects of evidence-based ICU care on long-term outcomes of patients with sepsis or septic shock (ILOSS): protocol for a multicentre prospective observational cohort study in Japan

    Liu, KB; Kotani, T; Nakamura, K; Chihiro, T; Morita, Y; Ishii, K; Fujizuka, K; Yasumura, D; Taniguchi, D; Hamagami, T; Shimojo, N; Nitta, M; Hongo, T; Akieda, K; Atsuo, M; Kaneko, T; Sakuda, Y; Andoh, K; Nagatomi, A; Tanaka, Y; Irie, Y; Kamijo, H; Hanazawa, M; Kasugai, D; Ayaka, M; Oike, K; Lefor, AK; Takahashi, K; Katsukawa, H; Ogura, T

    BMJ OPEN   Vol. 12 ( 3 ) page: e054478   2022.3

     More details

  37. Pre-pregnancy sleep duration and postpartum depression: a multicenter study in Japan Reviewed

    Matsuo, S; Ushida, T; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    ARCHIVES OF WOMENS MENTAL HEALTH   Vol. 25 ( 1 ) page: 181 - 189   2022.2

     More details

  38. Clinical guide for women with mental health problems during the perinatal period Reviewed

    Shimoya, K; Kotani, T; Satoh, S; Suzuki, S; Kashima, H; Ogasawara, K; Ozaki, N; Suzuki, E; Tachibana, Y; Suzuki, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 1 ) page: 20 - 33   2022.1

     More details

  39. Liver transaminase levels during pregnancy: a Japanese multicenter study

    Ushida, T; Kotani, T; Kinoshita, F; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE   Vol. 35 ( 25 ) page: 5761 - 5767   2022

     More details

  40. Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study Reviewed

    Katsuki, S; Ushida, T; Kidokoro, H; Nakamura, N; Iitani, Y; Fuma, K; Imai, K; Nakano-Kobayashi, T; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    EARLY HUMAN DEVELOPMENT   Vol. 163   page: 105479   2021.12

     More details

  41. 高次医療機関における母体血を用いた出生前遺伝学的検査導入前後での羊水染色体検査状況の検討 Reviewed

    橋本 佑樹, 村松 友佳子, 伊藤 美春, 齊藤 明子, 佐藤 義朗, 牛田 貴文, 小谷 友美, 早川 昌弘

    日本周産期・新生児医学会誌     2021.12

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

  42. Stepwise Treatment for Abnormally Invasive Placenta with Placenta Previa Reviewed

    Sumigama, S; Kotani, T; Hayakawa, H

    SURGERY JOURNAL   Vol. 07 ( Suppl 1 ) page: S20 - S27   2021.12

     More details

  43. Prevalence and risk factors of labor-onset hypertension: A multicenter study in Japan Reviewed

    Ushida, T; Kotani, T; Imai, K; Nakano-Kobayashi, T; Iitani, Y; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 26   page: 48 - 53   2021.12

     More details

  44. Annual body mass index gain and risk of hypertensive disorders of pregnancy in a subsequent pregnancy Reviewed

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Iitani, Y; Kinoshita, F; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 22519   2021.11

     More details

  45. Tadalafil treatment for preeclampsia (medication in preeclampsia; MIE): a multicenter phase II clinical trial

    Furuhashi, F; Tanaka, H; Maki, S; Tsuji, M; Magawa, S; Kaneda, MK; Nii, M; Tanaka, K; Ogura, T; Nishimura, Y; Endoh, M; Kimura, T; Kotani, T; Sekizawa, A; Ikeda, T

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE   Vol. 34 ( 22 ) page: 3709 - 3715   2021.11

     More details

  46. Manual removal of the placenta and postpartum hemorrhage: A multicenter retrospective study Reviewed

    Fujita, K; Ushida, T; Imai, K; Nakano-Kobayashi, T; Iitani, Y; Matsuo, S; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 11 ) page: 3867 - 3874   2021.11

     More details

  47. Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction Reviewed

    Nomoto, M; Kotani, T; Miki, R; Ushida, T; Imai, K; Iitani, Y; Tano, S; Wang, JW; Moriyama, Y; Kobayashi, T; Mimura, N; Iriyama, T; Kikkawa, F; Kajiyama, H

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 69 ( 3 ) page: 280 - 285   2021.11

     More details

  48. Current Issues within the Perinatal Mental Health Care System in Aichi Prefecture, Japan: A Cross-Sectional Questionnaire Survey Reviewed

    Fujita, K; Kotani, T; Moriyama, Y; Ushida, T; Imai, K; Kobayashi-Nakano, T; Kato, N; Kano, T; Kikkawa, F; Kajiyama, H

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH   Vol. 18 ( 17 )   2021.9

     More details

  49. Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia Reviewed

    Miura, M; Imai, K; Tsuda, H; Miki, R; Tano, S; Ito, Y; Hirako-Takamura, S; Moriyama, Y; Ushida, T; Iitani, Y; Nakano-Kobayashi, T; Toyokuni, S; Kajiyama, H; Kotani, T

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 22 ( 17 )   2021.9

     More details

  50. Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study Reviewed

    Ushida, T; Kidokoro, H; Nakamura, N; Katsuki, S; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 25   page: 143 - 149   2021.8

     More details

  51. Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia. Reviewed International coauthorship

    Deprest JA, Nicolaides KH, Benachi A, Gratacos E, Ryan G, Persico N, Sago H, Johnson A, Wielgoś M, Berg C, Van Calster B, Russo FM; TOTAL Trial for Severe Hypoplasia Investigators.

    N Engl J Med   Vol. 385 ( 2 ) page: 107 - 118   2021.7

     More details

    Language:English  

  52. Antenatal prediction models for short- and medium-term outcomes in preterm infants

    Ushida, T; Moriyama, Y; Nakatochi, M; Kobayashi, Y; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Hayakawa, M; Kajiyama, H; Kotani, T

    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA   Vol. 100 ( 6 ) page: 1089 - 1096   2021.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/aogs.14136

    Web of Science

    PubMed

  53. Platelet counts during normal pregnancies and pregnancies complicated with hypertensive disorders Reviewed

    Ushida, T; Kotani, T; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Kinoshita, F; Nakamura, N; Iitani, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 24   page: 73 - 78   2021.6

     More details

  54. Assessment of myocardial performance index in late-onset fetal growth restriction Reviewed International coauthorship

    Nguyen, TTN; Kotani, T; Imai, K; Ushida, T; Moriyama, Y; Kobayashi, T; Niimi, K; Sumigama, S; Yamamoto, E; Vo, VD; Le, MT; Le, LH; Nguyen, DN; Nguyen, VQH; Truong, QV; Cao, NT; Kikkawa, F

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 2 ) page: 259 - 268   2021.5

     More details

  55. Postpartum alterations following inflammation in rat pregnancy: a discovery proteomic analysis Reviewed International coauthorship

    Ushida, T; Kotani, T; Moriyama, Y; Hindmarch, CCT; Cotechini, T; Imai, K; Nakano-Kobayashi, T; Kajiyama, H; Graham, CH

    REPRODUCTION   Vol. 161 ( 5 ) page: 513 - 522   2021.5

     More details

  56. Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia

    Ito, Y; Tsuda, H; Imai, K; Miki, R; Miura, M; Tachi, A; Tano, S; Hirako-Takamura, S; Moriyama, Y; Ushida, T; Kobayashi, T; Sumigama, S; Kajiyama, H; Kikkawa, F; Kotani, T

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 700   page: 108769   2021.3

     More details

  57. Trisomy 5p with bilateral congenital diaphragmatic hernia: a case report

    Nakamura, N; Ushida, T; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Osuka, S; Goto, M; Kajiyama, H; Asada, H; Hayakawa, M; Kotani, T

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 15 ( 1 ) page: 114   2021.3

     More details

  58. Maternal low birth weight and hypertensive disorders of pregnancy

    Ushida, T; Kotani, T; Kinoshita, F; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 23   page: 5 - 10   2021.3

     More details

  59. Shock Index and Postpartum Hemorrhage in Vaginal Deliveries: A Multicenter Retrospective Study

    Ushida, T; Kotani, T; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H; Kikkawa, F

    SHOCK   Vol. 55 ( 3 ) page: 332 - 337   2021.3

     More details

  60. Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage

    Owaki, T; Imai, K; Miki, R; Niwa, Y; Kotani, T; Nakano-Kobayashi, T; Ushida, T; Kajiyama, H

    CYTOKINE   Vol. 138   page: 155406   2021.2

     More details

  61. Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy

    Nakamura, N; Ushida, T; Nakatochi, M; Kobayashi, Y; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H; Kikkawa, F; Kotani, T

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 1729   2021.1

     More details

  62. Very Low Levels of Serum Anti-Mullerian Hormone as a Possible Marker for Follicle Growth in Patients with Primary Ovarian Insufficiency Under Hormone Replacement Therapy

    Kasahara, Y; Osuka, S; Bayasula; Nakanishi, N; Murase, T; Nakamura, T; Goto, M; Kotani, T; Iwase, A; Kikkawa, F

    REPRODUCTIVE SCIENCES   Vol. 28 ( 1 ) page: 31 - 36   2021.1

     More details

  63. Feasibility and outcomes of fetoscopic endoluminal tracheal occlusion for severe congenital diaphragmatic hernia: A Japanese experience

    Wada, S; Ozawa, K; Sugibayashi, R; Suyama, F; Amari, S; Ito, Y; Kanamori, Y; Okuyama, H; Usui, N; Sasahara, J; Kotani, T; Hayakawa, M; Kato, K; Taguchi, T; Endo, M; Sago, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 46 ( 12 ) page: 2598 - 2604   2020.12

     More details

  64. Focal Adhesion Kinase-Mediated Sequences, Including Cell Adhesion, Inflammatory Response, and Fibrosis, as a Therapeutic Target in Endometriosis

    Nagai, T; Ishida, C; Nakamura, T; Iwase, A; Mori, M; Murase, T; Bayasula; Osuka, S; Takikawa, S; Goto, M; Kotani, T; Kikkawa, F

    REPRODUCTIVE SCIENCES   Vol. 27 ( 7 ) page: 1400 - 1410   2020.7

     More details

  65. Antenatal corticosteroids and preterm offspring outcomes in hypertensive disorders of pregnancy: A Japanese cohort study

    Ushida, T; Kotani, T; Hayakawa, M; Hirakawa, A; Sadachi, R; Nakamura, N; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Kikkawa, F

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 9312   2020.6

     More details

  66. Antenatal Corticosteroids and Outcomes in Preterm Twins

    Ushida, T; Kotani, T; Sadachi, R; Hirakawa, A; Hayakawa, M; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Kikkawa, F

    OBSTETRICS AND GYNECOLOGY   Vol. 135 ( 6 ) page: 1387 - 1397   2020.6

     More details

  67. A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia

    Tachi, A; Moriyama, Y; Tsuda, H; Miki, R; Ushidai, T; Miura, M; Ito, Y; Imail, K; Nakano-Kobayashi, I; Hayakawa, M; Kikkawa, F; Kotani, T

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 345 - 354   2020.5

     More details

  68. The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study.

    Yamamoto E, Trinh TD, Sekiya Y, Tamakoshi K, Nguyen XP, Nishino K, Niimi K, Kotani T, Kajiyama H, Shibata K, Le QT, Kikkawa F

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 183 - 191   2020.5

     More details

    Language:English  

    DOI: 10.18999/nagjms.82.2.183

    PubMed

  69. Determination of the cytokine levels in fetal pleural effusion and their association with fetal/neonatal findings

    Imai, K; Kotani, T; Tsuda, H; Kobayashi, T; Ushida, T; Moriyama, Y; Kikkawa, F

    CYTOKINE   Vol. 127   page: 154945   2020.3

     More details

  70. Two-photon microscopic observation of cell-production dynamics in the developing mammalian neocortex in utero

    Kawasoe, R; Shinoda, T; Hattori, Y; Nakagawa, M; Pham, TQ; Tanaka, Y; Sagou, K; Saito, K; Katsuki, S; Kotani, T; Sano, A; Fujimori, T; Miyata, T

    DEVELOPMENT GROWTH & DIFFERENTIATION   Vol. 62 ( 2 ) page: 118 - 128   2020.2

     More details

  71. Outcome of cesarean scar pregnancy treated with local methotrexate injection

    Tam, LM; Kotani, T; Linh, TM; Thu, PTM; Khanh, TV; Anh, NTK; Nguyen, NTT; Moriyama, Y; Yamamoto, E; Huy, NVQ; Vinh, TQ; Thanh, CN; Kikkawa, F

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 1 ) page: 15 - 23   2020.2

     More details

  72. The efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide and actinomycin D in patients with choriocarcinoma and high-risk gestational trophoblastic neoplasia

    Sato, S; Yamamoto, E; Niimi, K; Ino, K; Nishino, K; Suzuki, S; Kotani, T; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 203 - 209   2020.1

     More details

  73. Adverse effects of endometriosis on pregnancy: a case-control study

    Miura, M; Ushida, T; Imai, K; Wang, JW; Moriyama, Y; Nakano-Kobayashi, T; Osuka, S; Kikkawa, F; Kotani, T

    BMC PREGNANCY AND CHILDBIRTH   Vol. 19 ( 1 ) page: 373   2019.10

     More details

  74. A pitfall in diagnosing fetal abdominal lymphangioma: A report of two cases.

    Niwa Y, Imai K, Kotani T, Nakano T, Ushida T, Moriyama Y, Kikkawa F

    Journal of clinical ultrasound : JCU   Vol. 47 ( 8 ) page: 494 - 496   2019.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcu.22756

    Web of Science

    PubMed

  75. Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy.

    Ishiguro T, Sugiyama Y, Ueda K, Muramatsu Y, Tsuda H, Kotani T, Michigami T, Tachikawa K, Akiyama T, Hayakawa M

    Brain & development   Vol. 41 ( 8 ) page: 721 - 725   2019.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.braindev.2019.03.015

    Web of Science

    PubMed

  76. Maternal protein S activity is associated with massive hemorrhage during caesarean section: retrospective case-control study.

    Imai K, Kotani T, Nakano T, Ushida T, Hirakawa A, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 32 ( 16 ) page: 2633 - 2637   2019.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14767058.2018.1443067

    Web of Science

    PubMed

  77. Feasibility of using a handheld tissue hardness meter to quantify uterine contractions and its clinical application for obstetric bleeding management

    Imai Kenji, Kotani Tomomi, Ushida Takafumi, Moriyama Yoshinori, Nakano Tomoko, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 39 ( 6 ) page: 757 - 762   2019.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/01443615.2019.1581748

    Web of Science

    PubMed

  78. Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia.

    Iriyama T, Wang G, Yoshikawa M, Mimura N, Matsui H, Sayama S, Kumasawa K, Nagamatsu T, Koga K, Kotani T, Niimi K, Yamamoto E, Kellems RE, Xia Y, Osuga Y, Fujii T

    Scientific reports   Vol. 9 ( 1 ) page: 10107   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-019-46660-4

    Web of Science

    PubMed

  79. Serological screening of immunoglobulin M and immunoglobulin G during pregnancy for predicting congenital cytomegalovirus infection

    Torii, Y; Yoshida, S; Yanase, Y; Mitsui, T; Horiba, K; Okumura, T; Takeuchi, S; Suzuki, T; Kawada, J; Kotani, T; Yamashita, M; Ito, Y

    BMC PREGNANCY AND CHILDBIRTH   Vol. 19 ( 1 ) page: 205   2019.6

     More details

  80. Safety Evaluation of Tadalafil Treatment for Fetuses with Early-Onset Growth Restriction (TADAFER): Results from the Phase II Trial

    Maki, S; Tanaka, H; Tsuji, M; Furuhashi, F; Magawa, S; Kaneda, MK; Nii, M; Tanaka, K; Kondo, E; Tamaru, S; Ogura, T; Nishimura, Y; Endoh, M; Kimura, T; Kotani, T; Sekizawa, A; Ikeda, T

    JOURNAL OF CLINICAL MEDICINE   Vol. 8 ( 6 )   2019.6

     More details

  81. Somatic symptom disorder manifested as acute abdominal pain during pregnancy preceding perinatal depression: a case report.

    Moriyama Y, Imai K, Nakano T, Kotani T, Kikkawa F

    Archives of women's mental health   Vol. 22 ( 2 ) page: 301 - 304   2019.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00737-018-0863-9

    Web of Science

    PubMed

  82. Relationship between cytokine profiles of cord blood and cord S100B levels in preterm infants

    Niwa, Y; Imai, K; Kotani, T; Miki, R; Nakano, T; Ushida, T; Moriyama, Y; Kikkawa, F

    EARLY HUMAN DEVELOPMENT   Vol. 129   page: 65 - 70   2019.2

     More details

  83. Isolation of group B <i>Streptococcus</i> with reduced β-lactam susceptibility from pregnant women

    Moroi, H; Kimura, K; Kotani, T; Tsuda, H; Banno, H; Jin, W; Wachino, J; Yamada, K; Mitsui, T; Yamashita, M; Kikkawa, F; Arakawa, Y

    EMERGING MICROBES & INFECTIONS   Vol. 8 ( 1 ) page: 2 - 7   2019.1

     More details

  84. The role of E2F8 in the human placenta

    Mizuno Masako, Miki Rika, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Niimi Kaoru, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Senga Takeshi, Iwase Akira, Kikkawa Fumitaka, Kotani Tomomi

    MOLECULAR MEDICINE REPORTS   Vol. 19 ( 1 ) page: 293 - 301   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/mmr.2018.9617

    Web of Science

    PubMed

  85. Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders

    Matsukawa, S; Sumigama, S; Kotani, T; Wang, JW; Miki, R; Moriyama, Y; Nakano, T; Mano, Y; Tsuda, H; Tamakoshi, K; Kikkawa, F

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 84 ( 4 ) page: 396 - 406   2019

     More details

  86. Clinical utility and limitations of FibCare (R) for the rapid measurement of fibrinogen concentrations: The first clinical experience

    Imai Kenji, Kotani Tomomi, Nakano Tomoko, Ushida Takafumi, Kikkawa Fumitaka

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   Vol. 57 ( 6 ) page: 899 - 900   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tjog.2018.10.024

    Web of Science

    PubMed

  87. A rare pseudo tumour in the extraembryonic coelom in first trimester of pregnancy: ultrasound and pathology.

    Sumigama S, Enomoto A, Matsukawa S, Ushida T, Imai K, Nakano T, Kotani T, Kikkawa F

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     page: 1-2   2018.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/01443615.2018.1511971

    PubMed

  88. Protective effects of mangafodipir against chemotherapy-induced ovarian damage in mice

    Qin, Y; Iwase, A; Murase, T; Bayasula; Ishida, C; Kato, N; Nakamura, T; Osuka, S; Takikawa, S; Goto, M; Kotani, T; Kikkawa, F

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 16 ( 1 ) page: 106   2018.10

     More details

  89. TADAFER II: Tadalafil treatment for fetal growth restriction - a study protocol for a multicenter randomised controlled phase II trial

    Umekawa Takashi, Maki Shintaro, Kubo Michiko, Tanaka Hiroaki, Nii Masafumi, Tanaka Kayo, Osato Kazuhiro, Kamimoto Yuki, Tamaru Satoshi, Ogura Toru, Nishimura Yuki, Kodera Mayumi, Minamide Chisato, Nishikawa Masakatsu, Endoh Masayuki, Kimura Tadashi, Kotani Tomomi, Nakamura Masamitsu, Sekizawa Akihiko, Ikeda Tomoaki

    BMJ OPEN   Vol. 8 ( 10 ) page: e020948   2018.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/bmjopen-2017-020948

    Web of Science

    PubMed

  90. The impact of fertility treatment on the neonatal respiratory outcomes and amniotic lamellar body counts in twin pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 484   page: 192 - 196   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cca.2018.05.060

    Web of Science

    PubMed

  91. The rate of neonatal respiratory distress syndrome/transient tachypnea in the newborn and the amniotic lamellar body count in twin pregnancies compared with singleton pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 484   page: 293 - 297   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cca.2018.06.015

    Web of Science

    PubMed

  92. Thyroid Autoantibodies do not Impair the Ovarian Reserve in Euthyroid Infertile Women: A Cross-Sectional Study

    Osuka Satoko, Iwase Akira, Goto Maki, Takikawa Sachiko, Nakamura Tomoko, Murase Tomohiko, Kato Nao, Bayasula, Kotani Tomomi, Kikkawa Fumitaka

    HORMONE AND METABOLIC RESEARCH   Vol. 50 ( 7 ) page: 537 - 542   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/a-0637-9430

    Web of Science

    PubMed

  93. Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model

    Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Ushida Takafumi, Iwase Akira, Nagai Taku, Toyokuni Shinya, Suzumura Akio, Kikkawa Fumitaka

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 9221   2018.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-27626-4

    Web of Science

    PubMed

  94. Effect of molecular hydrogen on uterine inflammation during preterm labour

    Nakano Tomoko, Kotani Tomomi, Imai Kenji, Iitani Yukako, Ushida Takafumi, Tsuda Hiroyuki, Li Hua, Iwase Akira, Toyokuni Shinya, Kikkawa Fumitaka

    BIOMEDICAL REPORTS   Vol. 8 ( 5 ) page: 454 - 460   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/br.2018.1082

    Web of Science

    PubMed

  95. Dengue fever during pregnancy.

    Tien Dat T, Kotani T, Yamamoto E, Shibata K, Moriyama Y, Tsuda H, Yamashita M, Kajiyama H, Duc Thien Minh D, Quang Thanh L, Kikkawa F

    Nagoya journal of medical science   Vol. 80 ( 2 ) page: 241 - 247   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagims.80.2.241

    Web of Science

    PubMed

  96. Altered proteomic profile in umbilical arterial serum from mothers with schizophrenia.

    Moriyama Y, Kotani T, Ushida T, Imai K, Nakano T, Tsuda H, Kikkawa F

    Schizophrenia research     2018.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.schres.2018.02.024

    PubMed

  97. Follicle dynamics: visualization and analysis of follicle growth and maturation using murine ovarian tissue culture.

    Murase T, Iwase A, Komatsu K, Bayasula, Nakamura T, Osuka S, Takikawa S, Goto M, Kotani T, Kikkawa F

    Journal of assisted reproduction and genetics   Vol. 35 ( 2 ) page: 339-343   2018.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10815-017-1073-5

    PubMed

  98. The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis.

    Moroi H, Kotani T, Miki R, Tsuda H, Mizuno M, Ito Y, Ushida T, Imai K, Nakano T, Li H, Sumigama S, Yamamoto E, Iwase A, Kikkawa F

    Journal of clinical biochemistry and nutrition   Vol. 62 ( 1 ) page: 63 - 67   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3164/jcbn.16-103

    Web of Science

    PubMed

  99. Simulation training is useful for shortening the decision-to-delivery interval in cases of emergent cesarean section.

    Iitani Y, Tsuda H, Ito Y, Moriyama Y, Nakano T, Imai K, Kotani T, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 31 ( 23 ) page: 3128 - 3132   2018

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14767058.2017.1365126

    Web of Science

    PubMed

  100. Association of serum asymmetric dimethylarginine, homocysteine, and L-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy

    Maruta Ei, Wang Jingwen, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Imai Kenji, Sumigama Seiji, Niwa Yoshimitsu, Mitsui Takashi, Yoshida Shigeru, Yamashita Mamoru, Nawa Akihiro, Tamakoshi Koji, Kajiyama Hiroaki, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 475   page: 70 - 77   2017.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cca.2017.10.007

    Web of Science

    PubMed

  101. Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114)

    Hirako Shima, Tsuda Hiroyuki, Ito Fumiya, Okazaki Yasumasa, Hirayama Tasuku, Nagasawa Hideko, Nakano Tomoko, Imai Kenji, Kotani Tomomi, Kikkawa Fumitaka, Toyokuni Shinya

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 61 ( 3 ) page: 176 - 182   2017.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3164/jcbn.17-17

    Web of Science

    PubMed

  102. Establishment and characterization of cell lines derived from complete hydatidiform mole

    Yamamoto Eiko, Niimi Kaoru, Kiyono Tohru, Yamamoto Toshimichi, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   Vol. 40 ( 3 ) page: 614 - 622   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ijmm.2017.3067

    Web of Science

    PubMed

  103. ABERRANT MATERNAL INFLAMMATION IN PREGNANCY LEADS TO PERSISTENCE OF RISK FACTORS FOR CARDIOVASCULAR DISEASE IN THE OFFSPRING

    Ushida Takafumi, Macdonald-Goodfellow Shannyn, Tse M. Yat, Winn Louise, Pang Stephen, Adams Michael, Kotani Tomomi, Kikkawa Fumitaka, Graham Charles

    PLACENTA   Vol. 57   page: 243 - 243   2017.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.placenta.2017.07.074

    Web of Science

  104. PERSISTENCE OF RISK FACTORS ASSOCIATED WITH MATERNAL CARDIOVASCULAR DISEASE FOLLOWING ABERRANT INFLAMMATION IN RAT PREGNANCY

    Ushida, T; Macdonald-Goodfellow, S; Quadri, A; Tse, MY; Winn, L; Pang, S; Adams, M; Kotani, T; Kikkawa, F; Graham, C

    PLACENTA   Vol. 57   page: 279 - 279   2017.9

  105. Persistence of risk factors associated with maternal cardiovascular disease following aberrant inflammation in rat pregnancy

    Ushida Takafumi, Macdonald-Goodfellow Shannyn K., Quadri Allegra, Tse M. Yat, Winn Louise M., Pang Stephen C., Adams Michael A., Kotani Tomomi, Kikkawa Fumitaka, Graham Charles H.

    BIOLOGY OF REPRODUCTION   Vol. 97 ( 1 ) page: 143 - 152   2017.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/biolre/iox072

    Web of Science

    PubMed

  106. c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling. Reviewed

    Sekiya Y, Yamamoto E, Niimi K, Nishino K, Nakamura K, Kotani T, Kajiyama H, Shibata K, Kikkawa F

    Oncology   Vol. 92 ( 5 )   2017.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000458529

    PubMed

  107. A Novel Approach to Detecting Postpartum Hemorrhage Using Contrast-Enhanced Ultrasound. Reviewed

    Imai K, Kotani T, Tsuda H, Nakano T, Hirakawa A, Kikkawa F

    Ultrasound in medicine & biology   Vol. 43 ( 3 ) page: 615-620   2017.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ultrasmedbio.2016.11.008

    PubMed

  108. Observed-to-expected MRI fetal lung volume can predict long-term lung morbidity in infants with congenital diaphragmatic hernia. Reviewed

    Tsuda H, Kotani T, Miura M, Ito Y, Hirako S, Nakano T, Imai K, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 30 ( 13 ) page: 1509 - 1513   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14767058.2017.1299126

    Web of Science

    PubMed

  109. A large mediastinal tumour invading into the liver with foetal hydrops: A rare case of infantile myofibromatosis

    Ushida Takafumi, Tsuda Hiroyuki, Takahara Taishi, Takahashi Yuichiro, Kotani Tomomi, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 37 ( 6 ) page: 821 - 823   2017

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/01443615.2017.1303468

    Web of Science

    PubMed

  110. Kisspeptin in the hypothalamus of two rat models of polycystic ovary syndrome. Reviewed

    Osuka S, Iwase A, Nakahara T, Kondo M, Saito A, Bayasula, Nakamura T, Takikawa S, Goto M, Kotani T, Kikkawa F

    Endocrinology     page: en20161333   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2016-1333

    PubMed

  111. Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single-institution experience. Reviewed

    Tamauchi S, Kajiyama H, Sakata J, Sekiya R, Suzuki S, Mizuno M, Utsumi F, Niimi K, Kotani T, Shibata K, Kikkawa F

    The journal of obstetrics and gynaecology research   Vol. 42 ( 12 ) page: 1796-1801   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.13100

    PubMed

  112. Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. Reviewed

    Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y, Wang J, Miki R, Yamamoto E, Iwase A, Bando YK, Hirayama M, Ohno K, Toyokuni S, Kikkawa F

    Free radical biology & medicine   Vol. 101   page: 524-533   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.freeradbiomed.2016.10.491

    PubMed

  113. Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model Reviewed

    Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y3, Wang J4, Miki R4, Yamamoto E5, Iwase A1, Bando YK6, Hirayama M7, Ohno K7, Toyokuni S8, Kikkawa F1.

    Free Radic Biol Med   Vol. 101   page: 524-533   2016.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 0.1016/j.freeradbiomed.2016.10.491.

  114. Lipocalin 2 as a new biomarker for fetal lung hypoplasia in congenital diaphragmatic hernia. Reviewed

    Tsuda H, Kotani T, Nakano T, Imai K, Hirako S, Li H, Kikkawa F

    Clinica chimica acta; international journal of clinical chemistry   Vol. 462   page: 71-76   2016.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cca.2016.08.023

    PubMed

  115. Serum pentraxin 3 as a possible marker for mature cystic teratomas. Reviewed

    Ishida C, Iwase A, Osuka S, Goto M, Takikawa S, Nakamura T, Kotani T, Kikkawa F

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology   Vol. 32 ( 9 ) page: 733-736   2016.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/09513590.2016.1157862

    PubMed

  116. Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia. Reviewed

    Hirako S, Tsuda H, Kotani T, Sumigama S, Mano Y, Nakano T, Imai K, Li H, Toyokuni S, Kikkawa F

    Phytotherapy research : PTR   Vol. 30 ( 9 ) page: 1474-80   2016.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ptr.5645

    PubMed

  117. Increase of kisspeptin-positive cells in the hypothalamus of a rat model of polycystic ovary syndrome. Reviewed

    Kondo M, Osuka S, Iwase A, Nakahara T, Saito A, Bayasula, Nakamura T, Goto M, Kotani T, Kikkawa F

    Metabolic brain disease   Vol. 31 ( 3 ) page: 673-81   2016.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11011-016-9807-0

    PubMed

  118. Severe Hemoperitoneum During Pregnancy with Obstructed Hemivagina and Ipsilateral Renal Anomaly Syndrome: A Case Report. Reviewed

    Muraoka A, Tsuda H, Kotani T, Kikkawa F

    The Journal of reproductive medicine   Vol. 61 ( 5-6 ) page: 290-4   2016.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

  119. Pain-reducing anesthesia prevents oxidative stress in human term placenta. Reviewed

    Tsuzuki Y, Yamashita Y, Hattori Y, Hua Li G, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S, Nishiwaki K, Toyokuni S

    Journal of clinical biochemistry and nutrition   Vol. 58 ( 2 ) page: 156-60   2016.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3164/jcbn.15-138

    PubMed

  120. Efficacy and safety of daikenchuto (TJ-100) in pregnant women with constipation. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Hayakawa H, Kikkawa F

    Taiwanese journal of obstetrics & gynecology   Vol. 55 ( 1 ) page: 26-9   2016.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tjog.2015.12.003

    PubMed

  121. Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia. Reviewed

    Imai K, Kotani T, Tsuda H, Mano Y, Nakano T, Ushida T, Li H, Miki R, Sumigama S, Iwase A, Hirakawa A, Ohno K, Toyokuni S, Takeuchi H, Mizuno T, Suzumura A, Kikkawa F

    Free radical biology & medicine   Vol. 91   page: 154-63   2016.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.freeradbiomed.2015.12.015

    PubMed

  122. Relationship between the cortisol levels in umbilical cord blood and neonatal RDS/TTN in twin pregnancies. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Nakano T, Hua L, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 29 ( 13 ) page: 2151-6   2016

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/14767058.2015.1077510

    PubMed

  123. Risk assessment for neonatal RDS/TTN using gestational age and the amniotic lamellar body count in twin pregnancies. Reviewed

    Tsuda H, Hirakawa A, Kotani T, Sumigama S, Mano Y, Nakano T, Imai K, Kawabata I, Takahashi Y, Iwagaki S, Kikkawa F

    Clinica chimica acta; international journal of clinical chemistry   Vol. 451 ( Pt B ) page: 301-4   2015.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cca.2015.10.013

    PubMed

  124. Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury. Reviewed

    Nakano T, Kotani T, Mano Y, Tsuda H, Imai K, Ushida T, Li H, Miki R, Sumigama S, Sato Y, Iwase A, Hirakawa A, Asai M, Toyokuni S, Kikkawa F

    Journal of clinical biochemistry and nutrition   Vol. 57 ( 3 ) page: 178-82   2015.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3164/jcbn.15-90

    PubMed

  125. Is the serum l-arginine level during early pregnancy a predictor of pregnancy-induced hypertension? Reviewed

    Wang J, Kotani T, Tsuda H, Mano Y, Sumigama S, Li H, Komatsu K, Miki R, Maruta E, Niwa Y, Mitsui T, Yoshida S, Yamashita M, Tamakoshi K, Kikkawa F

    Journal of clinical biochemistry and nutrition   Vol. 57 ( 1 ) page: 74-81   2015.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3164/jcbn.14-104

    PubMed

  126. Impact of warning bleeding on the cortisol level in the fetus and neonatal RDS/TTN in cases of placenta previa. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Hua L, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 28 ( 9 ) page: 1057-60   2015.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/14767058.2014.942632

    PubMed

  127. Viral load in children with congenital cytomegalovirus infection identified on newborn hearing screening. Reviewed

    Kawada J, Torii Y, Kawano Y, Suzuki M, Kamiya Y, Kotani T, Kikkawa F, Kimura H, Ito Y

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology   Vol. 65   page: 41-5   2015.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jcv.2015.01.015

    PubMed

  128. CYP51A1 induced by growth differentiation factor 9 and follicle-stimulating hormone in granulosa cells is a possible predictor for unfertilization. Reviewed

    Nakamura T, Iwase A, Bayasula B, Nagatomo Y, Kondo M, Nakahara T, Takikawa S, Goto M, Kotani T, Kiyono T, Kikkawa F

    Reproductive sciences (Thousand Oaks, Calif.)   Vol. 22 ( 3 ) page: 377-84   2015.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1933719114529375

    PubMed

  129. Amniotic lamellar body count: predicting and distinguishing neonatal respiratory complications in twin pregnancies. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Kawabata I, Takahashi Y, Iwagaki S, Hirakawa A, Kikkawa F

    Clinica chimica acta; international journal of clinical chemistry   Vol. 441   page: 75-8   2015.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cca.2014.12.019

    PubMed

  130. Catalytic ferrous iron in amniotic fluid as a predictive marker of human maternal-fetal disorders. Reviewed

    Hattori Y, Mukaide T, Jiang L, Kotani T, Tsuda H, Mano Y, Sumigama S, Hirayama T, Nagasawa H, Kikkawa F, Toyokuni S

    Journal of clinical biochemistry and nutrition   Vol. 56 ( 1 ) page: 57-63   2015.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3164/jcbn.14-82

    PubMed

  131. Administration of umbilical cord blood cells transiently decreased hypoxic-ischemic brain injury in neonatal rats. Reviewed

    Hattori T, Sato Y, Kondo T, Ichinohashi Y, Sugiyama Y, Yamamoto M, Kotani T, Hirata H, Hirakawa A, Suzuki S, Tsuji M, Ikeda T, Nakanishi K, Kojima S, Blomgren K, Hayakawa M

    Developmental neuroscience   Vol. 37 ( 2 ) page: 95-104   2015

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000368396

    PubMed

  132. Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition. Reviewed

    Minakami H, Maeda T, Fujii T, Hamada H, Iitsuka Y, Itakura A, Itoh H, Iwashita M, Kanagawa T, Kanai M, Kasuga Y, Kawabata M, Kobayashi K, Kotani T, Kudo Y, Makino Y, Matsubara S, Matsuda H, Miura K, Murakoshi T, Murotsuki J, Ohkuchi A, Ohno Y, Ohshiba Y, Satoh S, Sekizawa A, Sugiura M, Suzuki S, Takahashi T, Tsukahara Y, Unno N, Yoshikawa H

    The journal of obstetrics and gynaecology research   Vol. 40 ( 6 ) page: 1469-99   2014.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.12419

    PubMed

  133. Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Reviewed

    Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, Ohno K, Kikkawa F, Toyokuni S

    Free radical biology & medicine   Vol. 69   page: 324-30   2014.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.freeradbiomed.2014.01.037

    PubMed

  134. Effect of placenta previa on neonatal respiratory disorders and amniotic lamellar body counts at 36-38weeks of gestation. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Hua L, Hayakawa H, Hayakawa M, Sato Y, Kikkawa F

    Early human development   Vol. 90 ( 1 ) page: 51-4   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.earlhumdev.2013.10.005

    PubMed

  135. Possible involvement of CD10 in the development of endometriosis due to its inhibitory effects on CD44-dependent cell adhesion. Reviewed

    Iwase A, Kotani T, Goto M, Kobayashi H, Takikawa S, Nakahara T, Nakamura T, Kondo M, Bayasula, Nagatomo Y, Kikkawa F

    Reproductive sciences (Thousand Oaks, Calif.)   Vol. 21 ( 1 ) page: 82-8   2014.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1933719113488449

    PubMed

  136. Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor.

    Kotani T, Iwase A, Tsuda H, Mano Y, Yamamoto E, Nakano T, Hasegawa Y, Li H, Sumigama S, Itakura A, Kikkawa F

    Biol Reprod   Vol. 89 ( 3 )   2013.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1095/biolreprod.

  137. A proteomic analysis of human follicular fluid: comparison between fertilized oocytes and non-fertilized oocytes in the same patient. Reviewed

    Bayasula, Iwase A, Kobayashi H, Goto M, Nakahara T, Nakamura T, Kondo M, Nagatomo Y, Kotani T, Kikkawa F

    Journal of assisted reproduction and genetics   Vol. 30 ( 9 ) page: 1231-8   2013.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10815-013-0004-3

    PubMed

  138. Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. Reviewed

    Kotani T, Iwase A, Tsuda H, Mano Y, Yamamoto E, Nakano T, Hasegawa Y, Li H, Sumigama S, Itakura A, Kikkawa F

    Biology of reproduction   Vol. 89 ( 3 ) page: 52   2013.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1095/biolreprod.113.108480

    PubMed

  139. The expression and characterization of endoglin in uterine leiomyosarcoma. Reviewed

    Mitsui H, Shibata K, Mano Y, Suzuki S, Umezu T, Mizuno M, Yamamoto E, Kajiyama H, Kotani T, Senga T, Kikkawa F

    Clinical & experimental metastasis   Vol. 30 ( 6 ) page: 731-40   2013.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10585-013-9574-9

    PubMed

  140. Amniotic lamellar body count and congenital diaphragmatic hernia in humans and in a rat model. Reviewed

    Watanabe Y, Tsuda H, Kotani T, Sumigama S, Mano Y, Hayakawa M, Sato Y, Kikkawa F

    Pediatric research   Vol. 73 ( 3 ) page: 344-8   2013.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/pr.2012.187

    PubMed

  141. Mucinous cystic neoplasm of the pancreas with severe dysplasia during pregnancy: case report and review of the literature. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Shimoyama Y, Kikkawa F

    Taiwanese journal of obstetrics & gynecology   Vol. 51 ( 4 ) page: 635-8   2012.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tjog.2012.09.022

    PubMed

  142. A case report of placental mesenchymal dysplasia with an increased VEGF-D expression.

    Kotani T, Sumigama S, Tsuda H, Mano Y, Yamamoto E, Iwase A, Shimoyama Y, Nagasaka T, Hayakawa H, Yamamoto T, Ino K, Kikkawa F.

    Placenta   Vol. 33 ( 10 ) page: 888-91   2012.10

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  143. Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway. Reviewed

    Nakahara T, Iwase A, Nakamura T, Kondo M, Bayasula, Kobayashi H, Takikawa S, Manabe S, Goto M, Kotani T, Kikkawa F

    Fertility and sterility   Vol. 98 ( 4 ) page: 1001-8.e1   2012.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.fertnstert.2012.06.008

    PubMed

  144. Validity of lamellar body count as a fetal lung maturity assessment in twin pregnancy. Reviewed

    Tsuda H, Kotani T, Sumigama S, Kawabata I, Takahashi Y, Iwagaki S, Kigoshi K, Kikkawa F

    Twin research and human genetics : the official journal of the International Society for Twin Studies   Vol. 15 ( 4 ) page: 547-9   2012.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1017/thg.2012.29

    PubMed

  145. Establishment of a human nonluteinized granulosa cell line that transitions from the gonadotropin-independent to the gonadotropin-dependent status. Reviewed

    Bayasula, Iwase A, Kiyono T, Takikawa S, Goto M, Nakamura T, Nagatomo Y, Nakahara T, Kotani T, Kobayashi H, Kondo M, Manabe S, Kikkawa F

    Endocrinology   Vol. 153 ( 6 ) page: 2851-60   2012.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2011-1810

    PubMed

  146. Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptides. Reviewed

      Vol. 7 ( 8 ) page: e43745   2012

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0043745

    PubMed

  147. The loss of endoglin promotes the invasion of extravillous trophoblasts. Reviewed

    Mano Y, Kotani T, Shibata K, Matsumura H, Tsuda H, Sumigama S, Yamamoto E, Iwase A, Senga T, Kikkawa F

    Endocrinology   Vol. 152 ( 11 ) page: 4386-94   2011.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2011-1088

    PubMed

  148. Maternal mental disorders and pregnancy outcomes: a clinical study in a Japanese population. Reviewed

    Hironaka M, Kotani T, Sumigama S, Tsuda H, Mano Y, Hayakawa H, Tanaka S, Ozaki N, Tamakoshi K, Kikkawa F

    The journal of obstetrics and gynaecology research   Vol. 37 ( 10 ) page: 1283-9   2011.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1447-0756.2010.01512.x

    PubMed

  149. Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment. Reviewed

    Iwase A, Goto M, Manabe S, Hirokawa W, Kobayashi H, Nakahara T, Takikawa S, Kotani T, Sumigama S, Tsuda H, Nakayama T, Suzuki N, Matsushita T, Kikkawa F

    Fertility and sterility   Vol. 95 ( 6 ) page: 2124.e5-7   2011.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.fertnstert.2011.01.011

    PubMed

  150. Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN). Reviewed

    Tsuda H, Takahashi Y, Iwagaki S, Uchida Y, Kawabata I, Hayakawa M, Sumigama S, Hayakawa H, Kotani T, Kikkawa F

    Journal of perinatal medicine   Vol. 39 ( 3 ) page: 245-50   2011.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1515/JPM.2011.006

    PubMed

  151. Intra-amniotic infection increases amniotic lamellar body count before 34 weeks of gestation. Reviewed

    Tsuda H, Takahashi Y, Iwagaki S, Kawabata I, Hayakawa H, Kotani T, Shibata K, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 23 ( 10 ) page: 1230-6   2010.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/14767051003615442

    PubMed

  152. Elevated levels of aldosterone in the amniotic fluid was observed in two cases of congenital mesoblastic nephroma. Reviewed

    Kotani T, Sumigama S, Hayakawa H, Mano Y, Tsuda H, Sugiyama C, Kawachi F, Hironaka M, Kato T, Kaneko K, Hayakawa M, Kikkawa F.

    Ultrasound Obstet Gynecol.   Vol. 36 ( 2 ) page: 256-8   2010.8

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  153. Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells. Reviewed

    Morimitsu A, Sumigama S, Kotani T, Mano Y, Suzuki K, Araki-Taguchi M, Yamamoto E, Hayakawa H, Okada M, Itakura A, Kikkawa F

    Gynecologic and obstetric investigation   Vol. 69 ( 1 ) page: 67-72   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000257663

    PubMed

  154. *Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line Reviewed

    Kotani T, Iwase A, Ino K, Sumigama S, Yamamoto E, Hayakawa H, Nagasaka T, Itakura A, Nomura S, Kikkawa F

    Endocrinology   Vol. 150 ( 9 ) page: 4376-4385   2009.9

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    The reduced migration/invasion of extravillous trophoblasts (EVTs) is a key feature of the genesis of preeclampsia. We and others previously reported that transcriptional factors activator protein-2 (AP-2) alpha and AP-2gamma act as suppressors of tumor invasion. The present study examined the expressions of AP-2alpha and AP-2gamma in preeclamptic placenta vs. control placenta and investigated their effect on the function of EVTs. The expressions of AP-2alpha and AP-2gamma were elevated in the preeclamptic placentas in comparison with the gestational age-matched control placentas. Their expressions also increased in EVTs of the preeclamptic placentas. Thereafter, we transfected AP-2alpha or AP-2gamma into human EVT cell line, HTR-8/SVneo. The overexpression of AP-2alpha or AP-2gamma decreased the migratory and invasive abilities in HTR-8/SVneo cells. This was followed by the reduction of protease activated receptor-1 and matrix metalloproteinases and a significant induction of plasminogen activator inhibitor-1 and the tissue inhibitor of metalloproteinase-1. AP-2alpha and AP-2gamma were weakly expressed in the cultured EVTs and HTR-8/SVneo cells, whereas they were induced by TNF-alpha, which increases in preeclamptic placenta and impairs trophoblast invasion. In the presence of TNF-alpha, the invasion of the HTR-8/SVneo cells was partially restored by a blocking of AP-2 induction using small interfering RNA of AP-2. The present data suggest that AP-2 may suppress trophoblast migration and invasion, thus leading to a shallow placentation in preeclampsia.

  155. Placenta previa increta/percreta in Japan: a retrospective study of ultrasound findings, management and clinical course. Reviewed

    Sumigama S, Itakura A, Ota T, Okada M, Kotani T, Hayakawa H, Yoshida K, Ishikawa K, Hayashi K, Kurauchi O, Yamada S, Nakamura H, Matsusawa K, Sakakibara K, Ito M, Kawai M, Kikkawa F

    The journal of obstetrics and gynaecology research   Vol. 33 ( 5 ) page: 606-11   2007.10

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1447-0756.2007.00619.x

    PubMed

  156. Placental leucine aminopeptidase might regulate the effects of oxytocin with resolution in endothelial cells. Reviewed

    Sano M, Itakura A, Ito M, Takeuchi M, Okada M, Kotani T, Mizutani S, Kikkawa F

    Medical science monitor : international medical journal of experimental and clinical research   Vol. 11 ( 7 ) page: BR195-9   2005.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

▼display all

Books 12

  1. 精神疾患合併妊娠

    ( Role: Contributor)

    2023.12  ( ISBN:978-4-8404-8442-8

     More details

    Total pages:416   Language:Japanese Book type:Textbook, survey, introduction

  2. 【各種診療ガイドラインにみる挙児希望女性の合併症・併存疾患の取り扱い-プレコンセプションから妊娠・出産まで-】精神疾患 International journal

    佐藤 昌司, 小谷 友美( Role: Joint author)

    産婦人科の実際  2023.4 

     More details

    Responsible for pages:393-399   Language:Japanese Book type:Scholarly book

    DOI: 10.18888/sp.0000002523

  3. 今日の治療指針私はこう治療している2023

    ( Role: Contributor)

    2023.1 

     More details

    Language:Japanese

  4. 治療法の再整理とアップデートのために 専門家による私の治療 産褥乳腺炎(解説)

    小谷友美( Role: Sole author)

    日本医事新報  2022.12 

     More details

    Responsible for pages:50   Language:Japanese

  5. 【帝王切開分娩のすべて-この1冊でわかるNew Normal Standard】術式の工夫 子宮筋層縫合術の工夫 縫合不全・瘢痕部菲薄化の予防のために(解説)

    小谷友美 牛田貴文( Role: Joint author)

    2022.12 

     More details

    Responsible for pages:1196-1201   Language:Japanese

    DOI: 10.11477/mf.1409210835

  6. 【産婦人科における素朴な疑問と解説(2)産科編】Rh式血液型不適合妊娠よりずっと頻度が高いABO式血液型不適合妊娠でトラブルが少ないのはなぜ?(解説)

    田野翔 小谷友美( Role: Joint author)

    産科と婦人科  2022.11 

     More details

    Responsible for pages:1201-1205   Language:Japanese

  7. 【生殖医療の安全性-どんなリスクと留意点があるのか?】受精卵,児・家族への影響 先天性心疾患と循環器系異常(解説)

    森本 美仁, 小谷 友美, 加藤 太一

    臨床婦人科産科  2022.11 

     More details

    Responsible for pages:1123-1128   Language:Japanese

  8. 【見て、聞いて、触って、身体所見から考える妊産褥婦の異常とその対応】帯下が多い、臭う(解説)

    松尾聖子 小谷友美( Role: Joint author)

    周産期医学   2022.8 

     More details

    Responsible for pages:1145-1147   Language:Japanese

  9. 【子宮内膜症の最新知識-この1冊で重要ポイントを網羅する】周産期予後 子宮内膜症・子宮腺筋症女性における周産期合併症リスクの考察(解説)

    小谷友美 牛田貴文( Role: Joint author)

    2022.7 

     More details

    Responsible for pages:670-675   Language:Japanese

    DOI: 10.11477/mf.1409210741

  10. 今日の治療指針私はこう治療している2022

    小谷友美( Role: Contributor ,  妊娠悪阻)

    医学書院  2022.1 

     More details

    Responsible for pages:1381-1382  

  11. 胎児超音波診断を活かす-産科医と新生児科医からの情報提供-

    小谷友美、伊藤美春(胸腔内疾患 先天性横隔膜ヘルニア)

    周産期医学  2021.9 

  12. 【周産期の周辺を強化する-プレコンセプションケアと産後ケアの充実に向けて】

    小谷友美.(他科と連携したプレコンセプションケアと産後ケア 精神科医/心療内科医・公認心理師との連携 産婦人科から.)

    周産期医学  2021.4 

▼display all

Presentations 5

  1. 胎児期の環境がこころの発達に及ぼす影響 Invited

    小谷友美

    超早産児神経発達症研究会 2023年度セミナー 

     More details

    Event date: 2023.9

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  2. 学会の取り組み 精神疾患を合併した、或いは合併の可能性のある妊産婦の診療ガイドの活用法 Invited

    小谷友美

    母と子のメンタルヘルス研修会(入門編)  2023.6.3 

     More details

    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  3. 妊産婦の不安によりそう NIPTの運用  Invited

    小谷友美

    愛知県周産期協議会専門相談研修会  2023.3.9 

     More details

    Event date: 2023.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  4. 胎児期の管理 胎内炎症が神経発達に及ぼす影響 Invited

    小谷友美

    第1回超早産児神経発達症研究会セミナー   2022.9.25 

     More details

    Event date: 2022.9

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  5. メンタル不調の妊産婦さんへの支援を考える Invited

    小谷友美

    愛知県産婦人科医会 MCMC母と子のメンタルヘルス研修会(入門編)  2022.7.2 

     More details

    Event date: 2022.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

Research Project for Joint Research, Competitive Funding, etc. 2

  1. 妊娠高血圧症候群の成因へのエンドグリンの関与の解明

    2011.4

    神澤医学研究振興財団第15回研究助成金 

      More details

    Grant type:Competitive

    妊娠高血圧症候群は、未だに母児ともに予後不良な疾患である。児は子宮内胎児発育遅延を合併し、新生児医
    療の進歩によりその生存率は改善したものの、脳障害などの後遺障害が問題となる。他方、母体では、HELLP
    症候群や脳血管障害といった重篤な合併症が問題となっている。脳血管障害は、我が国の妊産婦死亡原因の約
    25%を占めることが明らかとなり、その管理に関心が高まっている。病態は絨毛外絨毛細胞(EVT)の母体脱落
    膜への浸潤不全による胎盤低形成にあるとされるものの、未だ不明な点が多いために、有効な予防法や治療法
    が確立されていない。我々は、癌研究領域でのendoglinが細胞浸潤へ関与するという報告およびに妊娠高血圧
    症候群胎盤ではendoglin発現が増加するという報告に着目し、endoglinが胎盤低形成に関与しているという
    仮説をたてた。Endoglinが低酸素やTGF-といった胎盤低形成因子によって発現増加するという報告や、ラッ
    ト動物実験でその注入によりHELLP症候群モデルを作成したという報告もあり、本研究では、成因を解明する
    と同時に、重篤な合併症の発症予測・予防法を確立し、妊娠高血圧症候群の予後の向上を目指したい。

  2. 胎盤プロテアーゼとその転写因子AP-2からみた妊娠中毒症の病態解明と治療法の展開

    2002.4 - 2004.12

    財団法人 日母おぎゃー献金基金 

      More details

    Grant type:Competitive

    転写因子が妊娠高血圧症候群の病態に関与しており、よりその機構を明らかにすることにより、妊娠高血圧症候群の発症予防にも応用できる可能性が示唆された

KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. Interdisciplinary research toward the feto-maternal interface environmental strategies with targeted proteomics

    Grant number:23KK0157  2023.9 - 2027.3

    Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (International Collaborative Research)

      More details

    Authorship:Principal investigator 

    Grant amount:\21060000 ( Direct Cost: \16200000 、 Indirect Cost:\4860000 )

  2. 早産児の神経学的予後向上に向けた病態解明~腸脳相関に着目して~

    Grant number:22K09638  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    小谷 友美

      More details

    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    近年、女性が多様な生き方を選択・実現できる社会へと変容し、晩産化や生殖補助医療による妊娠が増加している。さらに、食行動も変化している。これらの生活様式の変化は、妊娠高血圧腎症や早産など周産期合併症の発症リスクと関連する。本研究では、効率的な戦略として、妊娠前からの予防戦略を開発する。動物モデルや臨床検体を用いた解析を実施し、母体腸内細菌叢および関連する食行動などを統合的に理解する知見を確立し、最終的には、児の神経学的後遺症発症を防止する妊娠前からの介入法の開発を目指す。
    新生仔マウス脳より回収した初代培養ミクログリアにIL-17受容体の発現を確認し、IL-17A添加によるmiRNAの発現変化の解析を行ったところ、複数のmiRNAが発現量の差を認めた。validation解析でひとつの候補にしぼり、ターゲット解析で、ターゲット遺伝子の解析も行っている。このmiRNAと相同であるヒトのmiRNAも同様のターゲット遺伝子を有することも in silico解析で明らかとなり、臨床での知見に橋渡しとなる発見と考えている。これにより、maternal immune activation仮説のトリガーとして知られる母体のIL-17Aが胎仔脳に移行しミクログリアのエピジェネティック変化をもたらす機構の解明に寄与する知見と考え、現在結果を論文にまとめ投稿中である。LPS動物モデルにおけるミクログリアの解析でも、LPS誘導のMIAモデルでのCD11c発現ミクログリアの割合が生後の限定された時期に減少していることが判明した。現在、異常腸内細菌叢モデルとして、抗生剤投与モデルでの早産率が高くなることが判明したが、早産仔の生存率が低いため、異常腸内細菌叢モデルとして既報告のある、高脂肪食モデルを作成中である。母獣の腹腔内脂肪の増加を確認しており、プレコンセプションケアにつながる知見を期待している。高脂肪食モデルでは妊孕性が低下しており、妊娠率向上に向けて条件設定を行っている。さらに、胎内環境による児の神経発達への知見として、大うつ病妊婦から出生した児の臍帯血により胎内環境の影響を示唆する知見を得ており、論文投稿中である。
    ミクログリア細胞実験では、ヒトの知見につながる発見となった。動物モデルに関しては、LPSモデルにおける実験系でミクログリアの単離やその解析による結果が得られた。抗生剤投与モデルでの解析は中断しているが、高脂肪食モデルでの解析を新たに立ちあげ進行中である。
    異常腸内細菌叢モデルとして、抗生剤投与モデルから、高脂肪食モデルを作成に切り替えた。妊孕性低下が課題であるため、実験に使用するマウスの数を増加させ、獲得仔数を増加させる計画に切り替えた。高脂肪食への費用増加を抑えるため、既報告をもとに、最短の高脂肪食負荷期間に切り替え、費用の削減、研究時間の短縮を図っている。

  3. 新規自己抗体標的抗原に着目した自己免疫関連生殖機能障害の病態解明と早期診断法確立

    Grant number:20H03819  2020.4 - 2024.3

    科学研究費助成事業  基盤研究(B)

    岩瀬 明, 北原 慈和, 大須賀 智子, 小松 紘司, 小谷 友美

      More details

    Authorship:Coinvestigator(s) 

    不妊症・不育症には自己免疫疾患が合併することがあるが、その詳細は不明である。我々は患者血清中に存在する自己抗体とその標的タンパクProstate, ovary, testis, ankyrin domain family member F (POTEF)を同定した。POTEFは卵巣、胎盤に特異性高く発現し、自己免疫機序によるPOTEFの障害が卵巣機能不全、反復流産の病態であるという仮説をたてた。
    卵巣、胎盤におけるPOTEFの機能解析を行うとともに、抗POTE抗体をマウスに投与し、自己免疫機序による病態の再現が可能かどうか検証する。抗POTEF抗体のアッセイ系を用い臨床的検討もあわせて行う。
    今なお卵巣機能不全、反復流産といった治療困難な不妊症・不育症が存在する。これらの疾患には自己免疫疾患が合併することがあり、自己免疫機序が推定されているがその詳細は不明である。我々は、甲状腺自己抗体陽性卵巣機能不全患者血清中に卵巣顆粒膜細胞に反応する自己抗体を見出し、LC/MS/MSを用い、その標的タンパクProstate, ovary, testis, ankyrin domain family member F (POTEF)を同定した。
    昨年度までの研究で、POTEFがヒト卵巣顆粒膜細胞および卵母細胞で発現し、卵胞発育により発現が変化することを見出し、さらにin vitroの実験からPOTEF発現により細胞増殖が抑制されること、この機序にオートファジー抑制が関与することを実験的に証明した。加えて精製POTEFタンパクを使用したヒト血清中の抗POTEF抗体アッセイ系の基盤を確立した(予備実験の段階で特許出願中)。卵巣機能不全患者血清中の抗POTEF抗体価を測定したところ、正常卵巣機能女性より有意に高いという結果を得た。次にPOTEF発現と患者背景と不妊治療成績との関連を検討したが、体外受精患者顆粒膜細胞POTEF発現と患者背景、臨床成績との関連は見出せなかった。
    POTEFのプロモーター領域に卵巣分化に重要な転写因子FOXL2の結合部位があることをデータベース検索で見出した。前述の顆粒膜細胞でのFOXL2発現解析でPCOS患者で高値の傾向をみとめた。PCOS女性の卵巣切片を用いた評価では、FOXL2の核移行が阻害されていることを見出した。
    さらにFOXL2に関連し、初期卵胞のリクルートメント関連因子を探索したところ、タモキシフェンが関与することを見出し、動物実験により作用を検証した。
    初年度のPOTEF機能解析、2年目の臨床検体での解析は予定通りであった。3年目では甲状腺機能不全モデルマウスの作製にしたが、想定した表現型を得るために試行を繰り返している状態である。打開策として研究の方向性を再検討し、POTEF発現調節に関係すると推測されるFOXL2の発現解析、PCOS表現型との関連解析を並行してすすめている。
    令和5年度も引き続き甲状腺機能不全マウスを作製する。薬剤投与量・時期、アジュバントとなるサイログロブリン投与量・時期について再検討を行う。モデルマウスが得られた段階で、甲状腺機能低下と卵巣機能の関連について、卵巣でのPOTEの発現変化との関連を検証する。
    POTEF発現調節についてはFOXL2を中心に解析を行う。不死化顆粒膜細胞株を用いてFOXL2強制発現およびノックダウン株を作製し、POTEF依存性、非依存性の遺伝子発現および表現系変化を探索する。
    また、FOXL2発現とPCOSとの関連が示されたことをうけ、研究の展開を再構成する。具体的には、アンドロゲン投与によるPCOSモデル動物を作製し、その病態に関するFOXL2、POTEF発現との関連を解析する。さらにヒトPCOS女性から得られた卵巣切片を用い、免疫組織染色でFOXL2、POTEF発現を解析する。
    自己免疫性卵巣機能不全の原因因子としてのPOTEF解析研究から、FOXL2-POTEF系と各種卵巣疾患との関わりについて解析し幅広く研究を展開する。

  4. Epigenetic change by perinatal inflammation and its regulation

    Grant number:17K11230  2017.4 - 2020.3

    KOTANI TOMOMI

      More details

    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Preterm birth occurs by inflammation, and the fetus is affected by exposure to inflammation. In the present study, it was shown that exposure to inflammation in utero caused postnatal autism spectrum like findings, accompanied with several alterations in the brain tissues, amyglada, including microglial activation. Furthermore, some of the molecular mechanisms have been elucidated. In addition, as a preventive strategy against , the results suggesting that antenatal molecular hydrogen administration may prevent the development of postnatal neuropsychiatric disorders in preterm infants. Pregnant women with other inflammation related diseases will be also indicated as candidates for this preventive strategy, although further studies are needed.

  5. Interdisciplinary study of obstetric management and gynecological rare tumor in Vietnam

    Grant number:15H02660  2015.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    FUMITAKA KIKKAWA

      More details

    Authorship:Coinvestigator(s) 

    For the purpose of not only the development of obstetrics and gynecology in Vietnam, but also creation of evidence worldwide and building of medical research resources to Japan, we investigated obstetric management and gynecological rare tumor in Vietnam at several facilities in Vietnam. In the present study, several findings, which are related to improvement of mothers and children's prognosis,were gained. First, Pregnancy with dengue fever causes thrombocytopenia, which is at risk of postpartum hemorrhage. Second, cesarean section scar pregnancy with an increase in cesarean section rate in Vietnam, could be managed by medication for only selected patients. Third, evaluation of cardiac function by ultrasound examination for fetal growth restriction would be beneficial. Lastly, we found that there was a high secondary rate after molar pregnancy in Vietnam and preventive measures might improve it.

  6. 早産児の後遺症発症の減少を目指して~分子状水素を用いた新規治療法の開発~

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

    小谷 友美

      More details

    Authorship:Principal investigator 

  7. 妊娠高血圧症候群の病態機序へのスフィンゴシン1リン酸の関与の解明と治療への応用

    2008.4

    科学研究費補助金  基盤研究(C) 20599006

      More details

    Authorship:Principal investigator 

    妊娠高血圧症候群の病態へのスフィンゴシン1リン酸(S1P)の関与を証明し、S1P受容体をターゲットとした新しい治療法を提示することを目的としている。現在では、妊娠高血圧症候群は絨毛外栄養膜細胞(extravillous trophoblast, EVT)の母体脱落膜への浸潤不全によって発症するという説が有力であり、本研究では、S1PのEVT浸潤機能に対する直接作用についてその分子機構まで解明する。また、S1Pの主な供給源は血球系であるとされているが、本研究では、脱落膜のスフィンゴシンキナーゼ(SK)により合成されたS1PがEVTをパラクラインに刺激しその浸潤を調節しているという仮説を証明する。S1PによるEVT浸潤調節の役割を証明した後、妊娠高血圧症候群症例におけるこれらの物質の発現を正常妊娠症例と比較検討する。さらに、新規免疫抑制薬FTY720をはじめとするS1P受容体作動薬の投与がEVT浸潤調節機構に及ぼす影響についてもその分子機構まで証明し、その治療的応用の可能性を提示していく。

▼display all

 

Teaching Experience (On-campus) 9

  1. 出生前診断

    2023

  2. 先天性感染とメンタルヘルス

    2023

  3. 胎盤形成メカニズムとその異常

    2023

  4. 周産期ハイリスクケア論

    2023

  5. 出生前診断

    2022

  6. 胎盤形成のメカニズムと異常

    2022

  7. 母子感染の予防と治療・周産期メンタルヘルス

    2022

  8. 胎盤形成のメカニズムと異常

    2020

  9. 母子感染の予防と治療・周産期メンタルヘルス

    2020

▼display all