Updated on 2023/09/12

写真a

 
KOTANI, Tomomi
 
Organization
Nagoya University Hospital Maternity and Perinatal Care Center Professor of hospital
Title
Professor of hospital
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 2002.3   名古屋大学 ) 

Research Interests 6

  1. preterm delovary

  2. preeclampsia

  3. invsion of trophoblast

  4. fetal development

  5. perinatal brain damage

  6. perinatal mental health

Research Areas 1

  1. Others / Others  / perinatology

Current Research Project and SDGs 3

  1. 胎内炎症曝露が及ぼすエピジェネティック変化とその制御

  2. 妊産婦前向きコホート研究の成果を用いた要介入群の同定法と支援策の開発

  3. 新規自己抗体標的抗原に着目した自己免疫関連生殖機能障害の病態解明と早期診断法確立

Research History 1

  1. Nagoya University   Nagoya University Hospital Maternity and Perinatal Care Center   Associate professor

    2018.7

Education 1

  1. Nagoya University   Graduate School, Division of Medicine

    1999.4 - 2002.3

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    Country: Japan

Professional Memberships 1

  1. 日本産婦人科学会、日本周産期.新生児学会、日本胎盤学会、日本人類遺伝学会、日本内分泌学会

    2006.4 - 2010.3

Committee Memberships 1

  1. 産婦人科診療ガイドライン委員会   委員  

    2014.4 - 2017.3   

 

Papers 152

  1. New-onset postpartum hypertension in women without a history of hypertensive disorders of pregnancy: a multicenter study in Japan

    Ushida Takafumi, Nakamura Noriyuki, Katsuki Satoru, Mizutani Hidesuke, Iitani Yukako, Imai Kenji, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi

    HYPERTENSION RESEARCH     2023.7

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  2. Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model

    Nakamura Noriyuki, Ushida Takafumi, Onoda Atsuto, Ueda Kazuto, Miura Ryosuke, Suzuki Toshihiko, Katsuki Satoru, Mizutani Hidesuke, Yoshida Kosuke, Tano Sho, Iitani Yukako, Imai Kenji, Hayakawa Masahiro, Kajiyama Hiroaki, Sato Yoshiaki, Kotani Tomomi

    FRONTIERS IN PEDIATRICS   Vol. 11   page: 1168173   2023.7

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  3. Comparison of the efficacy between controlled-release dinoprostone delivery system (PROPESS) and Cook's double balloon catheter plus oxytocin: A retrospective single-center study in Japan

    Imai Kenji, Nozaki Yuki, Ushida Takafumi, Tano Sho, Kajiyama Hiroaki, Kotani Tomomi

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 9 ) page: 2317 - 2323   2023.6

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  4. Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study

    Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakamura Noriyuki, Iitani Yukako, Moriyama Yoshinori, Emoto Ryo, Kato Sawako, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Matsui Shigeyuki, Kajiyama Hiroaki

    DIABETOLOGY & METABOLIC SYNDROME   Vol. 15 ( 1 ) page: 123   2023.6

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  5. Intrauterine exposure to chorioamnionitis and neuroanatomical alterations at term-equivalent age in preterm infants

    Nosaka Rena, Ushida Takafumi, Kidokoro Hiroyuki, Kawaguchi Masahiro, Shiraki Anna, Iitani Yukako, Imai Kenji, Nakamura Noriyuki, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS     2023.5

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  6. Antenatal corticosteroids-to-delivery interval associates cord blood S100B levels. Reviewed

    The journal of obstetrics and gynaecology research     2023.2

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15582

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  7. Clinical significances of Bishop score and vaginal bleeding to controlled-release dinoprostone delivery system (PROPESS) efficacy for cervical ripening: A retrospective single-center study in Japan. Reviewed

    The journal of obstetrics and gynaecology research     2023.2

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15575

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  8. Trend changes in age-related body mass index gain after coronavirus disease 2019 pandemic in Japan: a multicenter retrospective cohort study. Reviewed

    Reproductive biology and endocrinology : RB&E   Vol. 21 ( 1 ) page: 7   2023.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12958-023-01061-1

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  9. Prenatal diagnosis of distal 13q deletion syndrome in a fetus with esophageal atresia: a case report and review of the literature. Reviewed

    Journal of medical case reports   Vol. 16 ( 1 ) page: 481   2022.12

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    Authorship:Lead author, Corresponding author   Language:English  

    DOI: 10.1186/s13256-022-03713-z

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  10. Antenatal prediction models for outcomes of extremely and very preterm infants based on machine learning. Reviewed

    Ushida T, Kotani T, Baba J, Imai K, Moriyama Y, Nakano-Kobayashi T, Iitani Y, Nakamura N, Hayakawa M, Kajiyama H, Neonatal Research Network of Japan

    Archives of gynecology and obstetrics     2022.12

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    Language:English  

    DOI: 10.1007/s00404-022-06865-x

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  11. Aberrant inflammation in rat pregnancy leads to cardiometabolic alterations in their offspring and intrauterine growth restriction in the F2 generation Reviewed International coauthorship

    Ushida Takafumi, Cotechini Tiziana, Protopapas Nicole, Atallah Aline, Collyer Charlotte, Toews Alexa J., Macdonald-Goodfellow Shannyn K., Tse M. Yat, Winn Louise M., Pang Stephen C., Adams Michael A., Othman Maha, Kotani Tomomi, Kajiyama Hiroaki, Graham Charles H.

    JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE     page: 1 - 13   2022.12

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  12. Antenatal corticosteroids and outcomes of small for gestational age infants born at 24-31 gestational weeks: a population-based propensity score matching analysis. Reviewed

    Ushida T, Nakatochi M, Kobayashi Y, Nakamura N, Fuma K, Iitani Y, Imai K, Sato Y, Hayakawa M, Kajiyama H, Kotani T, Neonatal Research Network of Japan

    Archives of gynecology and obstetrics     2022.11

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00404-022-06834-4

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  13. Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells Reviewed

    Aoki Chieko, Imai Kenji, Mizutani Teruyuki, Sugiyama Daisuke, Miki Rika, Koya Yoshihiro, Kobayashi Tomoko, Ushida Takafumi, Iitani Yukako, Nakamura Noriyuki, Owaki Taro, Nishikawa Hiroyoshi, Toyokuni Shinya, Kajiyama Hiroaki, Kotani Tomomi

    LIFE SCIENCES   Vol. 308   page: 120955   2022.11

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lfs.2022.120955

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  14. Optimal annual body mass index change for preventing spontaneous preterm birth in a subsequent pregnancy. Reviewed

    Scientific reports   Vol. 12 ( 1 ) page: 17502   2022.10

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-22495-4

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  15. 5p deletion with congenital diaphragmatic hernia: a case report. Reviewed

    Kotani T, Ushida T, Nakamura N, Imai K, Iitani Y, Tano S, Iwagaki S, Takahashi Y, Ito M, Hayakawa M, Kajiyama H

    Journal of medical case reports   Vol. 16 ( 1 ) page: 390   2022.10

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    Authorship:Lead author, Corresponding author   Language:English  

    DOI: 10.1186/s13256-022-03579-1

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  16. A case of non-immune hydrops fetalis with maternal mirror syndrome diagnosed by trio-based exome sequencing: An autopsy case report and literature review. Reviewed

    Molecular genetics and metabolism reports   Vol. 33   page: 100925   2022.10

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    Authorship:Corresponding author   Language:English  

    DOI: 10.1016/j.ymgmr.2022.100925

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  17. Severe Congenital Diaphragmatic Hernia With Trisomy 9: A Case Report and Review of the Literature.

    Fuma K, Kotani T, Nakamura N, Ushida T, Kajiyama H

    Cureus   Vol. 14 ( 8 ) page: e28395   2022.8

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    Authorship:Corresponding author   Language:English  

    DOI: 10.7759/cureus.28395

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  18. Impact of hypertensive disorders of pregnancy on respiratory outcomes in extremely and very preterm infants: A population-based study in Japan Reviewed

    Ushida Takafumi, Nakamura Noriyuki, Nakatochi Masahiro, Kobayashi Yumiko, Sato Yoshiaki, Iitani Yukako, Imai Kenji, Nakano-Kobayashi Tomoko, Hayakawa Masahiro, Kajiyama Hiroaki, Kotani Tomomi, Neonatal Res Network Japan Neonatal Research Network of Japan

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 29   page: 54 - 60   2022.8

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.preghy.2022.06.003

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  19. Machine learning prediction models for postpartum depression: A multicenter study in Japan Reviewed

    Matsuo Seiko, Ushida Takafumi, Emoto Ryo, Moriyama Yoshinori, Iitani Yukako, Nakamura Noriyuki, Imai Kenji, Nakano-Kobayashi Tomoko, Yoshida Shigeru, Yamashita Mamoru, Matsui Shigeyuki, Kajiyama Hiroaki, Kotani Tomomi

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1775 - 1785   2022.7

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15266

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  20. Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb) Reviewed

    Maki Shintaro, Tanaka Hiroaki, Takakura Sho, Nii Masafumi, Tanaka Kayo, Ogura Toru, Kotera Mayumi, Nishimura Yuki, Tamaru Satoshi, Ushida Takafumi, Tanaka Yasuhiro, Kikuchi Norihiko, Kinjo Tadatsugu, Kawamura Hiroshi, Takano Mayumi, Nakamura Koji, Suga Sachie, Kasai Michi, Yasui Osamu, Nagao Kenji, Maegawa Yuka, Kotani Tomomi, Endo Masayuki, Yasuhi Ichiro, Aoki Shigeru, Aoki Yoichi, Yoshida Yoshio, Nakata Masahiko, Sekizawa Akihiko, Ikeda Tomoaki

    BMJ OPEN   Vol. 12 ( 6 ) page: e054925   2022.6

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  21. Intrauterine exposure to hypertensive disorders of pregnancy and postnatal growth in extremely and very preterm infants Reviewed

    Ushida Takafumi, Kotani Tomomi, Nakatochi Masahiro, Kobayashi Yumiko, Nakamura Noriyuki, Imai Kenji, Iitani Yukako, Nakano-Kobayashi Tomoko, Hayakawa Masahiro, Kajiyama Hiroaki

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 28   page: 174 - 179   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.preghy.2022.05.007

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  22. Reassessing the duration of each stage of labor and their relation to postpartum hemorrhage in the current Japanese population Reviewed

    Ushida Takafumi, Matsuo Seiko, Nakamura Noriyuki, Iitani Yukako, Imai Kenji, Nakano-Kobayashi Tomoko, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1760 - 1767   2022.6

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15280

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  23. The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia Reviewed

    Aoki Chieko, Imai Kenji, Owaki Taro, Kobayashi-Nakano Tomoko, Ushida Takafumi, Iitani Yukako, Nakamura Noriyuki, Kajiyama Hiroaki, Kotani Tomomi

    MEDICINA-LITHUANIA   Vol. 58 ( 6 )   2022.5

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/medicina58060731

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  24. Prevalence of common aneuploidy in twin pregnancies Reviewed

    Konishi Akiko, Samura Osamu, Muromoto Jin, Okamoto Yoko, Takahashi Hironori, Kasai Yasuyo, Ichikawa Mayuko, Yamada Naoki, Kato Noriko, Sato Hiroshi, Hamada Hiromi, Nakanami Naoyuki, Machi Maya, Ichizuka Kiyotake, Sunami Rei, Tanaka Toshitaka, Yonetani Naoto, Kamei Yoshimasa, Nagamatsu Takeshi, Matsumoto Mariko, Tairaku Shinya, Fujiwara Arisa, Nakamura Hiroaki, Harada Takashi, Watanabe Takafumi, Sasaki Shoko, Kawaguchi Satoshi, Minami Sawako, Ogawa Masaki, Miura Kiyonori, Suzumori Nobuhiro, Kojima Junya, Kotani Tomomi, Sasaki Rumi, Baba Tsukasa, Toyofuku Aya, Endo Masayuki, Takeshita Naoki, Taketani Takeshi, Sase Masakatsu, Matsubara Keiichi, Hayata Kei, Hamada Yoshinobu, Egawa Makiko, Kakinuma Toshiyuki, Matsushima Sachio, Kitagawa Michihiro, Shiga Tomomi, Kurashina Ryuhei, Hamada Hironori, Takagi Hiroaki, Kondo Akane, Miharu Norio, Yamashita Michiko, Horiya Madoka, Morimoto Keiji, Takahashi Ken, Okamoto Aikou, Sekizawa Akihiko, Sago Haruhiko

    JOURNAL OF HUMAN GENETICS   Vol. 67 ( 5 ) page: 261 - 265   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s10038-021-01001-0

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  25. Pregnancy Outcomes in Women with Thyroid Diseases. Reviewed

    Kotani T, Imai K, Ushida T, Moriyama Y, Nakano-Kobayashi T, Osuka S, Tsuda H, Sumigama S, Yamamoto E, Kinoshita F, Hirakawa A, Iwase A, Kikkawa F, Kajiyama H

    JMA journal   Vol. 5 ( 2 ) page: 216 - 223   2022.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.31662/jmaj.2021-0191

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  26. Assessment of placental abruption with diffusion-weighted imaging Reviewed

    Mizutani Teruyuki, Kotani Tomomi, Kato Noriko, Imai Kenji, Ushida Takafumi, Nakano-Kobayashi Tomoko, Kinoshita Yoshimi, Ito Masato, Kinoshita Fumie, Yamamuro Osamu, Kajiyama Hiroaki

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH     2022.4

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    Authorship:Corresponding author   Language:English  

    DOI: 10.1111/jog.15183

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  27. Crosstalk between foetal vasoactive peptide hormones and placental aminopeptidases regulates placental blood flow: Its significance in preeclampsia. Reviewed

    Yoshihara M, Mizutani S, Matsumoto K, Kato Y, Masuo Y, Tano S, Mizutani H, Kotani T, Mizutani E, Shibata K, Kajiyama H

    Placenta   Vol. 121   page: 32 - 39   2022.4

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    DOI: 10.1016/j.placenta.2022.02.016

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  28. Annual Body Mass Index Gain and Risk of Gestational Diabetes Mellitus in a Subsequent Pregnancy

    Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Iitani Yukako, Kinoshita Fumie, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Kajiyama Hiroaki

    FRONTIERS IN ENDOCRINOLOGY   Vol. 13   page: 815390   2022.3

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  29. Pre-pregnancy sleep duration and postpartum depression: a multicenter study in Japan Reviewed

    Matsuo Seiko, Ushida Takafumi, Iitani Yukako, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi

    ARCHIVES OF WOMENS MENTAL HEALTH   Vol. 25 ( 1 ) page: 181 - 189   2022.2

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    Authorship:Last author   Language:English  

    DOI: 10.1007/s00737-021-01136-1

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  30. Clinical guide for women with mental health problems during the perinatal period Reviewed

    Shimoya Koichiro, Kotani Tomomi, Satoh Shoji, Suzuki Shunji, Kashima Haruo, Ogasawara Kazuyoshi, Ozaki Norio, Suzuki Eiji, Tachibana Yoshiyuki, Suzuki Toshihito

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 1 ) page: 20 - 33   2022.1

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  31. Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study Reviewed

    Katsuki Satoru, Ushida Takafumi, Kidokoro Hiroyuki, Nakamura Noriyuki, Iitani Yukako, Fuma Kazuya, Imai Kenji, Nakano-Kobayashi Tomoko, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi

    EARLY HUMAN DEVELOPMENT   Vol. 163   page: 105479   2021.12

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    Authorship:Last author   Language:English  

    DOI: 10.1016/j.earlhumdev.2021.105479

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  32. Prevalence and risk factors of labor-onset hypertension: A multicenter study in Japan Reviewed

    Ushida Takafumi, Kotani Tomomi, Imai Kenji, Nakano-Kobayashi Tomoko, Iitani Yukako, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 26   page: 48 - 53   2021.12

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  33. 高次医療機関における母体血を用いた出生前遺伝学的検査導入前後での羊水染色体検査状況の検討 Reviewed

    橋本 佑樹, 村松 友佳子, 伊藤 美春, 齊藤 明子, 佐藤 義朗, 牛田 貴文, 小谷 友美, 早川 昌弘

    日本周産期・新生児医学会誌     2021.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  34. Stepwise Treatment for Abnormally Invasive Placenta with Placenta Previa Reviewed

    Sumigama Seiji, Kotani Tomomi, Hayakawa Hiromi

    SURGERY JOURNAL   Vol. 07 ( Suppl 1 ) page: S20 - S27   2021.12

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  35. Annual body mass index gain and risk of hypertensive disorders of pregnancy in a subsequent pregnancy Reviewed

    Tano Sho, Kotani Tomomi, Ushida Takafumi, Yoshihara Masato, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Iitani Yukako, Kinoshita Fumie, Yoshida Shigeru, Yamashita Mamoru, Kishigami Yasuyuki, Oguchi Hidenori, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 22519   2021.11

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    Authorship:Corresponding author   Language:English  

    DOI: 10.1038/s41598-021-01976-y

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  36. Manual removal of the placenta and postpartum hemorrhage: A multicenter retrospective study Reviewed

    Fujita Kei, Ushida Takafumi, Imai Kenji, Nakano-Kobayashi Tomoko, Iitani Yukako, Matsuo Seiko, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kotani Tomomi

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 11 ) page: 3867 - 3874   2021.11

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    Authorship:Last author   Language:English  

    DOI: 10.1111/jog.15004

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  37. Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction Reviewed

    Nomoto Masataka, Kotani Tomomi, Miki Rika, Ushida Takafumi, Imai Kenji, Iitani Yukako, Tano Sho, Wang Jingwen, Moriyama Yoshinori, Kobayashi Tomoko, Mimura Nobuko, Iriyama Takayuki, Kikkawa Fumitaka, Kajiyama Hiroaki

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 69 ( 3 ) page: 280 - 285   2021.11

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    Authorship:Corresponding author   Language:English  

    DOI: 10.3164/jcbn.21-37

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  38. Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia Reviewed

    Miura Mayo, Imai Kenji, Tsuda Hiroyuki, Miki Rika, Tano Sho, Ito Yumiko, Hirako-Takamura Shima, Moriyama Yoshinori, Ushida Takafumi, Iitani Yukako, Nakano-Kobayashi Tomoko, Toyokuni Shinya, Kajiyama Hiroaki, Kotani Tomomi

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 22 ( 17 )   2021.9

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  39. Current Issues within the Perinatal Mental Health Care System in Aichi Prefecture, Japan: A Cross-Sectional Questionnaire Survey Reviewed

    Fujita Kei, Kotani Tomomi, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Kobayashi-Nakano Tomoko, Kato Noriko, Kano Takeo, Kikkawa Fumitaka, Kajiyama Hiroaki

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH   Vol. 18 ( 17 )   2021.9

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  40. Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study Reviewed

    Ushida Takafumi, Kidokoro Hiroyuki, Nakamura Noriyuki, Katsuki Satoru, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 25   page: 143 - 149   2021.8

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    Authorship:Last author   Language:English  

    DOI: 10.1016/j.preghy.2021.06.003

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  41. Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia. Reviewed International coauthorship

    Deprest JA, Nicolaides KH, Benachi A, Gratacos E, Ryan G, Persico N, Sago H, Johnson A, Wielgoś M, Berg C, Van Calster B, Russo FM; TOTAL Trial for Severe Hypoplasia Investigators.

    N Engl J Med   Vol. 385 ( 2 ) page: 107 - 118   2021.7

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  42. Antenatal prediction models for short- and medium-term outcomes in preterm infants

    Ushida Takafumi, Moriyama Yoshinori, Nakatochi Masahiro, Kobayashi Yumiko, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Hayakawa Masahiro, Kajiyama Hiroaki, Kotani Tomomi

    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA   Vol. 100 ( 6 ) page: 1089 - 1096   2021.6

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/aogs.14136

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  43. Platelet counts during normal pregnancies and pregnancies complicated with hypertensive disorders Reviewed

    Ushida Takafumi, Kotani Tomomi, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Kinoshita Fumie, Nakamura Noriyuki, Iitani Yukako, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 24   page: 73 - 78   2021.6

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  44. Assessment of myocardial performance index in late-onset fetal growth restriction Reviewed International coauthorship

    Tran Thao Nguyen Nguyen, Kotani Tomomi, Imai Kenji, Ushida Takafumi, Moriyama Yoshinori, Kobayashi Tomoko, Niimi Kaoru, Sumigama Seiji, Yamamoto Eiko, Van Duc Vo, Minh Tam Le, Lam Huong Le, Dac Nguyen Nguyen, Vu Quoc Huy Nguyen, Quang Vinh Truong, Ngoc Thanh Cao, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 2 ) page: 259 - 268   2021.5

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    Authorship:Corresponding author   Language:English  

    DOI: 10.18999/nagjms.83.2.259

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  45. Postpartum alterations following inflammation in rat pregnancy: a discovery proteomic analysis Reviewed International coauthorship

    Ushida Takafumi, Kotani Tomomi, Moriyama Yoshinori, Hindmarch Charles C. T., Cotechini Tiziana, Imai Kenji, Nakano-Kobayashi Tomoko, Kajiyama Hiroaki, Graham Charles H.

    REPRODUCTION   Vol. 161 ( 5 ) page: 513 - 522   2021.5

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  46. Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia

    Ito Yumiko, Tsuda Hiroyuki, Imai Kenji, Miki Rika, Miura Mayo, Tachi Asuka, Tano Sho, Hirako-Takamura Shima, Moriyama Yoshinori, Ushida Takafumi, Kobayashi Tomoko, Sumigama Seiji, Kajiyama Hiroaki, Kikkawa Fumitaka, Kotani Tomomi

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 700   2021.3

  47. Trisomy 5p with bilateral congenital diaphragmatic hernia: a case report

    Nakamura Noriyuki, Ushida Takafumi, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Osuka Satoko, Goto Maki, Kajiyama Hiroaki, Asada Hideyuki, Hayakawa Masahiro, Kotani Tomomi

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 15 ( 1 ) page: 114   2021.3

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  48. Maternal low birth weight and hypertensive disorders of pregnancy

    Ushida Takafumi, Kotani Tomomi, Kinoshita Fumie, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 23   page: 5 - 10   2021.3

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  49. Shock Index and Postpartum Hemorrhage in Vaginal Deliveries: A Multicenter Retrospective Study

    Ushida Takafumi, Kotani Tomomi, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki, Kikkawa Fumitaka

    SHOCK   Vol. 55 ( 3 ) page: 332 - 337   2021.3

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  50. Liver transaminase levels during pregnancy: a Japanese multicenter study

    Ushida Takafumi, Kotani Tomomi, Kinoshita Fumie, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE     2021.2

  51. Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage

    Owaki Taro, Imai Kenji, Miki Rika, Niwa Yuri, Kotani Tomomi, Nakano-Kobayashi Tomoko, Ushida Takafumi, Kajiyama Hiroaki

    CYTOKINE   Vol. 138   2021.2

  52. Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy

    Nakamura Noriyuki, Ushida Takafumi, Nakatochi Masahiro, Kobayashi Yumiko, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Hayakawa Masahiro, Kajiyama Hiroaki, Kikkawa Fumitaka, Kotani Tomomi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 )   2021.1

  53. Very Low Levels of Serum Anti-Mullerian Hormone as a Possible Marker for Follicle Growth in Patients with Primary Ovarian Insufficiency Under Hormone Replacement Therapy

    Kasahara Yukiyo, Osuka Satoko, Bayasula, Nakanishi Natsuki, Murase Tomohiko, Nakamura Tomoko, Goto Maki, Kotani Tomomi, Iwase Akira, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 28 ( 1 ) page: 31 - 36   2021.1

  54. Feasibility and outcomes of fetoscopic endoluminal tracheal occlusion for severe congenital diaphragmatic hernia: A Japanese experience

    Wada Seiji, Ozawa Katsusuke, Sugibayashi Rika, Suyama Fumio, Amari Shoichiro, Ito Yushi, Kanamori Yutaka, Okuyama Hiroomi, Usui Noriaki, Sasahara Jun, Kotani Tomomi, Hayakawa Masahiro, Kato Kiyoko, Taguchi Tomoaki, Endo Masayuki, Sago Haruhiko

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 46 ( 12 ) page: 2598 - 2604   2020.12

  55. Focal Adhesion Kinase-Mediated Sequences, Including Cell Adhesion, Inflammatory Response, and Fibrosis, as a Therapeutic Target in Endometriosis

    Nagai Takashi, Ishida Chiharu, Nakamura Tomoko, Iwase Akira, Mori Masahiko, Murase Tomohiko, Bayasula, Osuka Satoko, Takikawa Sachiko, Goto Maki, Kotani Tomomi, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 27 ( 7 ) page: 1400 - 1410   2020.7

  56. Antenatal corticosteroids and preterm offspring outcomes in hypertensive disorders of pregnancy: A Japanese cohort study

    Ushida Takafumi, Kotani Tomomi, Hayakawa Masahiro, Hirakawa Akihiro, Sadachi Ryo, Nakamura Noriyuki, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Kikkawa Fumitaka

    SCIENTIFIC REPORTS   Vol. 10 ( 1 )   2020.6

  57. Antenatal Corticosteroids and Outcomes in Preterm Twins

    Ushida Takafumi, Kotani Tomomi, Sadachi Ryo, Hirakawa Akihiro, Hayakawa Masahiro, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Kikkawa Fumitaka

    OBSTETRICS AND GYNECOLOGY   Vol. 135 ( 6 ) page: 1387 - 1397   2020.6

  58. A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia

    Tachi Asuka, Moriyama Yoshinori, Tsuda Hiroyuki, Miki Rika, Ushidai Takafumi, Miura Mayo, Ito Yumiko, Imail Kenji, Nakano-Kobayashi Ibmoko, Hayakawa Masahiro, Kikkawa Fumitaka, Kotani Tomomi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 345 - 354   2020.5

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  59. The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study.

    Yamamoto E, Trinh TD, Sekiya Y, Tamakoshi K, Nguyen XP, Nishino K, Niimi K, Kotani T, Kajiyama H, Shibata K, Le QT, Kikkawa F

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 183 - 191   2020.5

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    DOI: 10.18999/nagjms.82.2.183

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  60. Determination of the cytokine levels in fetal pleural effusion and their association with fetal/neonatal findings

    Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Kobayashi Tomoko, Ushida Takafumi, Moriyama Yoshinori, Kikkawa Fumitaka

    CYTOKINE   Vol. 127   2020.3

  61. Two-photon microscopic observation of cell-production dynamics in the developing mammalian neocortex in utero

    Kawasoe Ryotaro, Shinoda Tomoyasu, Hattori Yuki, Nakagawa Mami, Pham Trung Quang, Tanaka Yoshihiro, Sagou Ken, Saito Kanako, Katsuki Satoru, Kotani Tomomi, Sano Akihito, Fujimori Toshihiko, Miyata Takaki

    DEVELOPMENT GROWTH & DIFFERENTIATION   Vol. 62 ( 2 ) page: 118 - 128   2020.2

  62. Outcome of cesarean scar pregnancy treated with local methotrexate injection

    Le Minh Tam, Kotani Tomomi, Tran Manh Linh, Phan Thi Minh Thu, Tran Viet Khanh, Nguyen Thi Kim Anh, Nguyen Tran Thao Nguyen, Moriyama Yoshinori, Yamamoto Eiko, Nguyen Vu Quoc Huy, Truong Quang Vinh, Cao Ngoc Thanh, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 1 ) page: 15 - 23   2020.2

  63. The efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide and actinomycin D in patients with choriocarcinoma and high-risk gestational trophoblastic neoplasia

    Sato Shizuka, Yamamoto Eiko, Niimi Kaoru, Ino Kazuhiko, Nishino Kimihiro, Suzuki Shiro, Kotani Tomomi, Kajiyama Hiroaki, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 203 - 209   2020.1

  64. Determinants of gait independence after mechanical ventilation in the intensive care unit: a Japanese multicenter retrospective exploratory cohort study

    Watanabe Shinichi, Kotani Toru, Taito Shunsuke, Ota Kohei, Ishii Kenzo, Ono Mika, Katsukawa Hajime, Kozu Ryo, Morita Yasunari, Arakawa Ritsuro, Suzuki Shuichi

    JOURNAL OF INTENSIVE CARE   Vol. 7 ( 1 )   2019.11

  65. Tadalafil treatment for preeclampsia (medication in preeclampsia; MIE): a multicenter phase II clinical trial

    Furuhashi Fumi, Tanaka Hiroaki, Maki Shintaro, Tsuji Makoto, Magawa Shoichi, Kaneda Michiko K., Nii Masafumi, Tanaka Kayo, Ogura Toru, Nishimura Yuki, Endoh Masayuki, Kimura Tadashi, Kotani Tomomi, Sekizawa Akihiko, Ikeda Tomoaki

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE     2019.11

  66. Adverse effects of endometriosis on pregnancy: a case-control study

    Miura Mayo, Ushida Takafumi, Imai Kenji, Wang Jingwen, Moriyama Yoshinori, Nakano-Kobayashi Tomoko, Osuka Satoko, Kikkawa Fumitaka, Kotani Tomomi

    BMC PREGNANCY AND CHILDBIRTH   Vol. 19 ( 1 )   2019.10

  67. A pitfall in diagnosing fetal abdominal lymphangioma: A report of two cases.

    Niwa Y, Imai K, Kotani T, Nakano T, Ushida T, Moriyama Y, Kikkawa F

    Journal of clinical ultrasound : JCU   Vol. 47 ( 8 ) page: 494 - 496   2019.10

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    DOI: 10.1002/jcu.22756

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  68. Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy.

    Ishiguro T, Sugiyama Y, Ueda K, Muramatsu Y, Tsuda H, Kotani T, Michigami T, Tachikawa K, Akiyama T, Hayakawa M

    Brain & development   Vol. 41 ( 8 ) page: 721 - 725   2019.9

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    DOI: 10.1016/j.braindev.2019.03.015

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  69. Maternal protein S activity is associated with massive hemorrhage during caesarean section: retrospective case-control study.

    Imai K, Kotani T, Nakano T, Ushida T, Hirakawa A, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 32 ( 16 ) page: 2633 - 2637   2019.8

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    DOI: 10.1080/14767058.2018.1443067

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  70. Feasibility of using a handheld tissue hardness meter to quantify uterine contractions and its clinical application for obstetric bleeding management

    Imai Kenji, Kotani Tomomi, Ushida Takafumi, Moriyama Yoshinori, Nakano Tomoko, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 39 ( 6 ) page: 757 - 762   2019.8

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    DOI: 10.1080/01443615.2019.1581748

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  71. Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia.

    Iriyama T, Wang G, Yoshikawa M, Mimura N, Matsui H, Sayama S, Kumasawa K, Nagamatsu T, Koga K, Kotani T, Niimi K, Yamamoto E, Kellems RE, Xia Y, Osuga Y, Fujii T

    Scientific reports   Vol. 9 ( 1 ) page: 10107   2019.7

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    DOI: 10.1038/s41598-019-46660-4

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  72. Serological screening of immunoglobulin M and immunoglobulin G during pregnancy for predicting congenital cytomegalovirus infection

    Torii Yuka, Yoshida Shigeru, Yanase Yoichiro, Mitsui Takashi, Horiba Kazuhiro, Okumura Toshihiko, Takeuchi Suguru, Suzuki Takako, Kawada Jun-ichi, Kotani Tomomi, Yamashita Mamoru, Ito Yoshinori

    BMC PREGNANCY AND CHILDBIRTH   Vol. 19   2019.6

  73. Safety Evaluation of Tadalafil Treatment for Fetuses with Early-Onset Growth Restriction (TADAFER): Results from the Phase II Trial

    Maki Shintaro, Tanaka Hiroaki, Tsuji Makoto, Furuhashi Fumi, Magawa Shoichi, Kaneda Michiko K., Nii Masafumi, Tanaka Kayo, Kondo Eiji, Tamaru Satoshi, Ogura Toru, Nishimura Yuki, Endoh Masayuki, Kimura Tadashi, Kotani Tomomi, Sekizawa Akihiko, Ikeda Tomoaki

    JOURNAL OF CLINICAL MEDICINE   Vol. 8 ( 6 )   2019.6

  74. Somatic symptom disorder manifested as acute abdominal pain during pregnancy preceding perinatal depression: a case report.

    Moriyama Y, Imai K, Nakano T, Kotani T, Kikkawa F

    Archives of women's mental health   Vol. 22 ( 2 ) page: 301 - 304   2019.4

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    DOI: 10.1007/s00737-018-0863-9

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  75. Relationship between cytokine profiles of cord blood and cord S100B levels in preterm infants

    Niwa Yuri, Imai Kenji, Kotani Tomomi, Miki Rika, Nakano Tomoko, Ushida Takafumi, Moriyama Yoshinori, Kikkawa Fumitaka

    EARLY HUMAN DEVELOPMENT   Vol. 129   page: 65 - 70   2019.2

  76. Isolation of group B Streptococcus with reduced beta-lactam susceptibility from pregnant women

    Moroi Hiroaki, Kimura Kouji, Kotani Tomomi, Tsuda Hiroyuki, Banno Hirotsugu, Jin Wanchun, Wachino Jun-ichi, Yamada Keiko, Mitsui Takashi, Yamashita Mamoru, Kikkawa Fumitaka, Arakawa Yoshichika

    EMERGING MICROBES & INFECTIONS   Vol. 8 ( 1 ) page: 2 - 7   2019.1

  77. The role of E2F8 in the human placenta

    Mizuno Masako, Miki Rika, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Niimi Kaoru, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Senga Takeshi, Iwase Akira, Kikkawa Fumitaka, Kotani Tomomi

    MOLECULAR MEDICINE REPORTS   Vol. 19 ( 1 ) page: 293 - 301   2019.1

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    DOI: 10.3892/mmr.2018.9617

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  78. Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders

    Matsukawa Satoshi, Sumigama Seiji, Kotani Tomomi, Wang Jingwen, Miki Rika, Moriyama Yoshinori, Nakano Tomoko, Mano Yukio, Tsuda Hiroyuki, Tamakoshi Koji, Kikkawa Fumitaka

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 84 ( 4 ) page: 396 - 406   2019

  79. Clinical utility and limitations of FibCare (R) for the rapid measurement of fibrinogen concentrations: The first clinical experience

    Imai Kenji, Kotani Tomomi, Nakano Tomoko, Ushida Takafumi, Kikkawa Fumitaka

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   Vol. 57 ( 6 ) page: 899 - 900   2018.12

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    DOI: 10.1016/j.tjog.2018.10.024

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  80. A rare pseudo tumour in the extraembryonic coelom in first trimester of pregnancy: ultrasound and pathology.

    Sumigama S, Enomoto A, Matsukawa S, Ushida T, Imai K, Nakano T, Kotani T, Kikkawa F

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     page: 1-2   2018.11

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    DOI: 10.1080/01443615.2018.1511971

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  81. Protective effects of mangafodipir against chemotherapy-induced ovarian damage in mice

    Qin Ying, Iwase Akira, Murase Tomohiko, Bayasula, Ishida Chiharu, Kato Nao, Nakamura Tomoko, Osuka Satoko, Takikawa Sachiko, Goto Maki, Kotani Tomomi, Kikkawa Fumitaka

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 16 ( 1 ) page: 106   2018.10

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  82. TADAFER II: Tadalafil treatment for fetal growth restriction - a study protocol for a multicenter randomised controlled phase II trial

    Umekawa Takashi, Maki Shintaro, Kubo Michiko, Tanaka Hiroaki, Nii Masafumi, Tanaka Kayo, Osato Kazuhiro, Kamimoto Yuki, Tamaru Satoshi, Ogura Toru, Nishimura Yuki, Kodera Mayumi, Minamide Chisato, Nishikawa Masakatsu, Endoh Masayuki, Kimura Tadashi, Kotani Tomomi, Nakamura Masamitsu, Sekizawa Akihiko, Ikeda Tomoaki

    BMJ OPEN   Vol. 8 ( 10 ) page: e020948   2018.10

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    DOI: 10.1136/bmjopen-2017-020948

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  83. The impact of fertility treatment on the neonatal respiratory outcomes and amniotic lamellar body counts in twin pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 484   page: 192 - 196   2018.9

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    DOI: 10.1016/j.cca.2018.05.060

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  84. The rate of neonatal respiratory distress syndrome/transient tachypnea in the newborn and the amniotic lamellar body count in twin pregnancies compared with singleton pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 484   page: 293 - 297   2018.9

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    DOI: 10.1016/j.cca.2018.06.015

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  85. DRUG REPOSITIONING FOR SEARCH THE DRUG TO SUPPORT PLACENTAL GROWTH

    Nomoto Masataka, Kotani Tomomi, Mizutani Teruyuki, Moriyama Yoshinori, Ushida Takefumi, Imai Kenji, Nakano Tomoko, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E21 - E21   2018.9

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  86. Thyroid Autoantibodies do not Impair the Ovarian Reserve in Euthyroid Infertile Women: A Cross-Sectional Study

    Osuka Satoko, Iwase Akira, Goto Maki, Takikawa Sachiko, Nakamura Tomoko, Murase Tomohiko, Kato Nao, Bayasula, Kotani Tomomi, Kikkawa Fumitaka

    HORMONE AND METABOLIC RESEARCH   Vol. 50 ( 7 ) page: 537 - 542   2018.7

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    DOI: 10.1055/a-0637-9430

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  87. Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model

    Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Ushida Takafumi, Iwase Akira, Nagai Taku, Toyokuni Shinya, Suzumura Akio, Kikkawa Fumitaka

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 9221   2018.6

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    DOI: 10.1038/s41598-018-27626-4

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  88. Dengue fever during pregnancy

    Trinh Tien Dat, Kotani Tomomi, Yamamoto Eiko, Shibata Kiyosumi, Moriyama Yoshinori, Tsuda Hiroyuki, Yamashita Mamoru, Kajiyama Hiroaki, Dien Duc Thien Minh, Le Quang Thanh, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 2 ) page: 241-247   2018.5

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    DOI: 10.18999/nagims.80.2.241

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  89. Effect of molecular hydrogen on uterine inflammation during preterm labour

    Nakano Tomoko, Kotani Tomomi, Imai Kenji, Iitani Yukako, Ushida Takafumi, Tsuda Hiroyuki, Li Hua, Iwase Akira, Toyokuni Shinya, Kikkawa Fumitaka

    BIOMEDICAL REPORTS   Vol. 8 ( 5 ) page: 454 - 460   2018.5

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    DOI: 10.3892/br.2018.1082

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  90. Dengue fever during pregnancy.

    Tien Dat T, Kotani T, Yamamoto E, Shibata K, Moriyama Y, Tsuda H, Yamashita M, Kajiyama H, Duc Thien Minh D, Quang Thanh L, Kikkawa F

    Nagoya journal of medical science   Vol. 80 ( 2 ) page: 241-247   2018.5

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    DOI: 10.18999/nagjms.80.2.241

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  91. Altered proteomic profile in umbilical arterial serum from mothers with schizophrenia.

    Moriyama Y, Kotani T, Ushida T, Imai K, Nakano T, Tsuda H, Kikkawa F

    Schizophrenia research     2018.3

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    DOI: 10.1016/j.schres.2018.02.024

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  92. Follicle dynamics: visualization and analysis of follicle growth and maturation using murine ovarian tissue culture.

    Murase T, Iwase A, Komatsu K, Bayasula, Nakamura T, Osuka S, Takikawa S, Goto M, Kotani T, Kikkawa F

    Journal of assisted reproduction and genetics   Vol. 35 ( 2 ) page: 339-343   2018.2

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    DOI: 10.1007/s10815-017-1073-5

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  93. The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis.

    Moroi H, Kotani T, Miki R, Tsuda H, Mizuno M, Ito Y, Ushida T, Imai K, Nakano T, Li H, Sumigama S, Yamamoto E, Iwase A, Kikkawa F

    Journal of clinical biochemistry and nutrition   Vol. 62 ( 1 ) page: 63-67   2018.1

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    DOI: 10.3164/jcbn.16-103

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  94. Simulation training is useful for shortening the decision-to-delivery interval in cases of emergent cesarean section.

    Iitani Y, Tsuda H, Ito Y, Moriyama Y, Nakano T, Imai K, Kotani T, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 31 ( 23 ) page: 3128 - 3132   2018

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    DOI: 10.1080/14767058.2017.1365126

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  95. Association of serum asymmetric dimethylarginine, homocysteine, and L-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy

    Maruta Ei, Wang Jingwen, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Imai Kenji, Sumigama Seiji, Niwa Yoshimitsu, Mitsui Takashi, Yoshida Shigeru, Yamashita Mamoru, Nawa Akihiro, Tamakoshi Koji, Kajiyama Hiroaki, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 475   page: 70 - 77   2017.12

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    DOI: 10.1016/j.cca.2017.10.007

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  96. Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114)

    Hirako Shima, Tsuda Hiroyuki, Ito Fumiya, Okazaki Yasumasa, Hirayama Tasuku, Nagasawa Hideko, Nakano Tomoko, Imai Kenji, Kotani Tomomi, Kikkawa Fumitaka, Toyokuni Shinya

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 61 ( 3 ) page: 176 - 182   2017.11

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    DOI: 10.3164/jcbn.17-17

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  97. ABERRANT MATERNAL INFLAMMATION IN PREGNANCY LEADS TO PERSISTENCE OF RISK FACTORS FOR CARDIOVASCULAR DISEASE IN THE OFFSPRING

    Ushida Takafumi, Macdonald-Goodfellow Shannyn, Tse M. Yat, Winn Louise, Pang Stephen, Adams Michael, Kotani Tomomi, Kikkawa Fumitaka, Graham Charles

    PLACENTA   Vol. 57   page: 243-243   2017.9

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    DOI: 10.1016/j.placenta.2017.07.074

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  98. Establishment and characterization of cell lines derived from complete hydatidiform mole

    Yamamoto Eiko, Niimi Kaoru, Kiyono Tohru, Yamamoto Toshimichi, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   Vol. 40 ( 3 ) page: 614 - 622   2017.9

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    DOI: 10.3892/ijmm.2017.3067

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  99. PERSISTENCE OF RISK FACTORS ASSOCIATED WITH MATERNAL CARDIOVASCULAR DISEASE FOLLOWING ABERRANT INFLAMMATION IN RAT PREGNANCY

    Ushida Takafumi, Macdonald-Goodfellow Shannyn, Quadri Allegra, Tse M. Yat, Winn Louise, Pang Stephen, Adams Michael, Kotani Tomomi, Kikkawa Fumitaka, Graham Charles

    PLACENTA   Vol. 57   page: 279 - 279   2017.9

  100. Persistence of risk factors associated with maternal cardiovascular disease following aberrant inflammation in rat pregnancy

    Ushida Takafumi, Macdonald-Goodfellow Shannyn K., Quadri Allegra, Tse M. Yat, Winn Louise M., Pang Stephen C., Adams Michael A., Kotani Tomomi, Kikkawa Fumitaka, Graham Charles H.

    BIOLOGY OF REPRODUCTION   Vol. 97 ( 1 ) page: 143 - 152   2017.7

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    DOI: 10.1093/biolre/iox072

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  101. c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling. Reviewed

    Sekiya Y, Yamamoto E, Niimi K, Nishino K, Nakamura K, Kotani T, Kajiyama H, Shibata K, Kikkawa F

    Oncology   Vol. 92 ( 5 )   2017.3

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    DOI: 10.1159/000458529

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  102. A Novel Approach to Detecting Postpartum Hemorrhage Using Contrast-Enhanced Ultrasound. Reviewed

    Imai K, Kotani T, Tsuda H, Nakano T, Hirakawa A, Kikkawa F

    Ultrasound in medicine & biology   Vol. 43 ( 3 ) page: 615-620   2017.3

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    DOI: 10.1016/j.ultrasmedbio.2016.11.008

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  103. A Novel Marker of Neonatal Respiratory Disorders: Umbilical 25-Hydroxyvitamin D (25(OH)D).

    Ito Yumiko, Tsuda Hiroyuki, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 24   page: 282A-282A   2017.3

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    Web of Science

  104. Observed-to-expected MRI fetal lung volume can predict long-term lung morbidity in infants with congenital diaphragmatic hernia. Reviewed

    Tsuda H, Kotani T, Miura M, Ito Y, Hirako S, Nakano T, Imai K, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 30 ( 13 ) page: 1509 - 1513   2017

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    DOI: 10.1080/14767058.2017.1299126

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  105. A large mediastinal tumour invading into the liver with foetal hydrops: A rare case of infantile myofibromatosis

    Ushida Takafumi, Tsuda Hiroyuki, Takahara Taishi, Takahashi Yuichiro, Kotani Tomomi, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 37 ( 6 ) page: 821 - 823   2017

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    DOI: 10.1080/01443615.2017.1303468

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  106. Kisspeptin in the hypothalamus of two rat models of polycystic ovary syndrome. Reviewed

    Osuka S, Iwase A, Nakahara T, Kondo M, Saito A, Bayasula, Nakamura T, Takikawa S, Goto M, Kotani T, Kikkawa F

    Endocrinology     page: en20161333   2016.12

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    DOI: 10.1210/en.2016-1333

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  107. Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model Reviewed

    Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y3, Wang J4, Miki R4, Yamamoto E5, Iwase A1, Bando YK6, Hirayama M7, Ohno K7, Toyokuni S8, Kikkawa F1.

    Free Radic Biol Med   Vol. 101   page: 524-533   2016.12

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    DOI: 0.1016/j.freeradbiomed.2016.10.491.

  108. Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single-institution experience. Reviewed

    Tamauchi S, Kajiyama H, Sakata J, Sekiya R, Suzuki S, Mizuno M, Utsumi F, Niimi K, Kotani T, Shibata K, Kikkawa F

    The journal of obstetrics and gynaecology research   Vol. 42 ( 12 ) page: 1796-1801   2016.12

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    DOI: 10.1111/jog.13100

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  109. Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. Reviewed

    Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y, Wang J, Miki R, Yamamoto E, Iwase A, Bando YK, Hirayama M, Ohno K, Toyokuni S, Kikkawa F

    Free radical biology & medicine   Vol. 101   page: 524-533   2016.12

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    DOI: 10.1016/j.freeradbiomed.2016.10.491

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  110. Lipocalin 2 as a new biomarker for fetal lung hypoplasia in congenital diaphragmatic hernia. Reviewed

    Tsuda H, Kotani T, Nakano T, Imai K, Hirako S, Li H, Kikkawa F

    Clinica chimica acta; international journal of clinical chemistry   Vol. 462   page: 71-76   2016.11

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    DOI: 10.1016/j.cca.2016.08.023

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  111. Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia. Reviewed

    Hirako S, Tsuda H, Kotani T, Sumigama S, Mano Y, Nakano T, Imai K, Li H, Toyokuni S, Kikkawa F

    Phytotherapy research : PTR   Vol. 30 ( 9 ) page: 1474-80   2016.9

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    DOI: 10.1002/ptr.5645

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  112. Serum pentraxin 3 as a possible marker for mature cystic teratomas. Reviewed

    Ishida C, Iwase A, Osuka S, Goto M, Takikawa S, Nakamura T, Kotani T, Kikkawa F

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology   Vol. 32 ( 9 ) page: 733-736   2016.9

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    DOI: 10.3109/09513590.2016.1157862

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  113. Increase of kisspeptin-positive cells in the hypothalamus of a rat model of polycystic ovary syndrome. Reviewed

    Kondo M, Osuka S, Iwase A, Nakahara T, Saito A, Bayasula, Nakamura T, Goto M, Kotani T, Kikkawa F

    Metabolic brain disease   Vol. 31 ( 3 ) page: 673-81   2016.6

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    DOI: 10.1007/s11011-016-9807-0

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  114. Severe Hemoperitoneum During Pregnancy with Obstructed Hemivagina and Ipsilateral Renal Anomaly Syndrome: A Case Report. Reviewed

    Muraoka A, Tsuda H, Kotani T, Kikkawa F

    The Journal of reproductive medicine   Vol. 61 ( 5-6 ) page: 290-4   2016.5

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  115. Pain-reducing anesthesia prevents oxidative stress in human term placenta. Reviewed

    Tsuzuki Y, Yamashita Y, Hattori Y, Hua Li G, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S, Nishiwaki K, Toyokuni S

    Journal of clinical biochemistry and nutrition   Vol. 58 ( 2 ) page: 156-60   2016.3

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    DOI: 10.3164/jcbn.15-138

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  116. Efficacy and safety of daikenchuto (TJ-100) in pregnant women with constipation. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Hayakawa H, Kikkawa F

    Taiwanese journal of obstetrics & gynecology   Vol. 55 ( 1 ) page: 26-9   2016.2

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    DOI: 10.1016/j.tjog.2015.12.003

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  117. Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia. Reviewed

    Imai K, Kotani T, Tsuda H, Mano Y, Nakano T, Ushida T, Li H, Miki R, Sumigama S, Iwase A, Hirakawa A, Ohno K, Toyokuni S, Takeuchi H, Mizuno T, Suzumura A, Kikkawa F

    Free radical biology & medicine   Vol. 91   page: 154-63   2016.2

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    DOI: 10.1016/j.freeradbiomed.2015.12.015

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  118. Relationship between the cortisol levels in umbilical cord blood and neonatal RDS/TTN in twin pregnancies. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Nakano T, Hua L, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 29 ( 13 ) page: 2151-6   2016

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    DOI: 10.3109/14767058.2015.1077510

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  119. Risk assessment for neonatal RDS/TTN using gestational age and the amniotic lamellar body count in twin pregnancies. Reviewed

    Tsuda H, Hirakawa A, Kotani T, Sumigama S, Mano Y, Nakano T, Imai K, Kawabata I, Takahashi Y, Iwagaki S, Kikkawa F

    Clinica chimica acta; international journal of clinical chemistry   Vol. 451 ( Pt B ) page: 301-4   2015.12

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    DOI: 10.1016/j.cca.2015.10.013

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  120. Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury. Reviewed

    Nakano T, Kotani T, Mano Y, Tsuda H, Imai K, Ushida T, Li H, Miki R, Sumigama S, Sato Y, Iwase A, Hirakawa A, Asai M, Toyokuni S, Kikkawa F

    Journal of clinical biochemistry and nutrition   Vol. 57 ( 3 ) page: 178-82   2015.11

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    DOI: 10.3164/jcbn.15-90

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  121. Is the serum l-arginine level during early pregnancy a predictor of pregnancy-induced hypertension? Reviewed

    Wang J, Kotani T, Tsuda H, Mano Y, Sumigama S, Li H, Komatsu K, Miki R, Maruta E, Niwa Y, Mitsui T, Yoshida S, Yamashita M, Tamakoshi K, Kikkawa F

    Journal of clinical biochemistry and nutrition   Vol. 57 ( 1 ) page: 74-81   2015.7

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    DOI: 10.3164/jcbn.14-104

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  122. Impact of warning bleeding on the cortisol level in the fetus and neonatal RDS/TTN in cases of placenta previa. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Hua L, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 28 ( 9 ) page: 1057-60   2015.6

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    DOI: 10.3109/14767058.2014.942632

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  123. Viral load in children with congenital cytomegalovirus infection identified on newborn hearing screening. Reviewed

    Kawada J, Torii Y, Kawano Y, Suzuki M, Kamiya Y, Kotani T, Kikkawa F, Kimura H, Ito Y

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology   Vol. 65   page: 41-5   2015.4

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    DOI: 10.1016/j.jcv.2015.01.015

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  124. CYP51A1 induced by growth differentiation factor 9 and follicle-stimulating hormone in granulosa cells is a possible predictor for unfertilization. Reviewed

    Nakamura T, Iwase A, Bayasula B, Nagatomo Y, Kondo M, Nakahara T, Takikawa S, Goto M, Kotani T, Kiyono T, Kikkawa F

    Reproductive sciences (Thousand Oaks, Calif.)   Vol. 22 ( 3 ) page: 377-84   2015.3

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    DOI: 10.1177/1933719114529375

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  125. Amniotic lamellar body count: predicting and distinguishing neonatal respiratory complications in twin pregnancies. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Kawabata I, Takahashi Y, Iwagaki S, Hirakawa A, Kikkawa F

    Clinica chimica acta; international journal of clinical chemistry   Vol. 441   page: 75-8   2015.2

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    DOI: 10.1016/j.cca.2014.12.019

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  126. Catalytic ferrous iron in amniotic fluid as a predictive marker of human maternal-fetal disorders. Reviewed

    Hattori Y, Mukaide T, Jiang L, Kotani T, Tsuda H, Mano Y, Sumigama S, Hirayama T, Nagasawa H, Kikkawa F, Toyokuni S

    Journal of clinical biochemistry and nutrition   Vol. 56 ( 1 ) page: 57-63   2015.1

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    DOI: 10.3164/jcbn.14-82

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  127. Administration of umbilical cord blood cells transiently decreased hypoxic-ischemic brain injury in neonatal rats. Reviewed

    Hattori T, Sato Y, Kondo T, Ichinohashi Y, Sugiyama Y, Yamamoto M, Kotani T, Hirata H, Hirakawa A, Suzuki S, Tsuji M, Ikeda T, Nakanishi K, Kojima S, Blomgren K, Hayakawa M

    Developmental neuroscience   Vol. 37 ( 2 ) page: 95-104   2015

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    DOI: 10.1159/000368396

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  128. Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition. Reviewed

    Minakami H, Maeda T, Fujii T, Hamada H, Iitsuka Y, Itakura A, Itoh H, Iwashita M, Kanagawa T, Kanai M, Kasuga Y, Kawabata M, Kobayashi K, Kotani T, Kudo Y, Makino Y, Matsubara S, Matsuda H, Miura K, Murakoshi T, Murotsuki J, Ohkuchi A, Ohno Y, Ohshiba Y, Satoh S, Sekizawa A, Sugiura M, Suzuki S, Takahashi T, Tsukahara Y, Unno N, Yoshikawa H

    The journal of obstetrics and gynaecology research   Vol. 40 ( 6 ) page: 1469-99   2014.6

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    DOI: 10.1111/jog.12419

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  129. Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Reviewed

    Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, Ohno K, Kikkawa F, Toyokuni S

    Free radical biology & medicine   Vol. 69   page: 324-30   2014.4

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    DOI: 10.1016/j.freeradbiomed.2014.01.037

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  130. Effect of placenta previa on neonatal respiratory disorders and amniotic lamellar body counts at 36-38weeks of gestation. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Hua L, Hayakawa H, Hayakawa M, Sato Y, Kikkawa F

    Early human development   Vol. 90 ( 1 ) page: 51-4   2014.1

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    DOI: 10.1016/j.earlhumdev.2013.10.005

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  131. Possible involvement of CD10 in the development of endometriosis due to its inhibitory effects on CD44-dependent cell adhesion. Reviewed

    Iwase A, Kotani T, Goto M, Kobayashi H, Takikawa S, Nakahara T, Nakamura T, Kondo M, Bayasula, Nagatomo Y, Kikkawa F

    Reproductive sciences (Thousand Oaks, Calif.)   Vol. 21 ( 1 ) page: 82-8   2014.1

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    DOI: 10.1177/1933719113488449

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  132. Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor.

    Kotani T, Iwase A, Tsuda H, Mano Y, Yamamoto E, Nakano T, Hasegawa Y, Li H, Sumigama S, Itakura A, Kikkawa F

    Biol Reprod   Vol. 89 ( 3 )   2013.9

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    DOI: 10.1095/biolreprod.

  133. A proteomic analysis of human follicular fluid: comparison between fertilized oocytes and non-fertilized oocytes in the same patient. Reviewed

    Bayasula, Iwase A, Kobayashi H, Goto M, Nakahara T, Nakamura T, Kondo M, Nagatomo Y, Kotani T, Kikkawa F

    Journal of assisted reproduction and genetics   Vol. 30 ( 9 ) page: 1231-8   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10815-013-0004-3

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  134. Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. Reviewed

    Kotani T, Iwase A, Tsuda H, Mano Y, Yamamoto E, Nakano T, Hasegawa Y, Li H, Sumigama S, Itakura A, Kikkawa F

    Biology of reproduction   Vol. 89 ( 3 ) page: 52   2013.9

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    DOI: 10.1095/biolreprod.113.108480

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  135. The expression and characterization of endoglin in uterine leiomyosarcoma. Reviewed

    Mitsui H, Shibata K, Mano Y, Suzuki S, Umezu T, Mizuno M, Yamamoto E, Kajiyama H, Kotani T, Senga T, Kikkawa F

    Clinical & experimental metastasis   Vol. 30 ( 6 ) page: 731-40   2013.8

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    DOI: 10.1007/s10585-013-9574-9

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  136. Amniotic lamellar body count and congenital diaphragmatic hernia in humans and in a rat model. Reviewed

    Watanabe Y, Tsuda H, Kotani T, Sumigama S, Mano Y, Hayakawa M, Sato Y, Kikkawa F

    Pediatric research   Vol. 73 ( 3 ) page: 344-8   2013.3

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    DOI: 10.1038/pr.2012.187

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  137. Mucinous cystic neoplasm of the pancreas with severe dysplasia during pregnancy: case report and review of the literature. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Shimoyama Y, Kikkawa F

    Taiwanese journal of obstetrics & gynecology   Vol. 51 ( 4 ) page: 635-8   2012.12

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    DOI: 10.1016/j.tjog.2012.09.022

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  138. A case report of placental mesenchymal dysplasia with an increased VEGF-D expression.

    Kotani T, Sumigama S, Tsuda H, Mano Y, Yamamoto E, Iwase A, Shimoyama Y, Nagasaka T, Hayakawa H, Yamamoto T, Ino K, Kikkawa F.

    Placenta   Vol. 33 ( 10 ) page: 888-91   2012.10

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  139. Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway. Reviewed

    Nakahara T, Iwase A, Nakamura T, Kondo M, Bayasula, Kobayashi H, Takikawa S, Manabe S, Goto M, Kotani T, Kikkawa F

    Fertility and sterility   Vol. 98 ( 4 ) page: 1001-8.e1   2012.10

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    DOI: 10.1016/j.fertnstert.2012.06.008

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  140. Validity of lamellar body count as a fetal lung maturity assessment in twin pregnancy. Reviewed

    Tsuda H, Kotani T, Sumigama S, Kawabata I, Takahashi Y, Iwagaki S, Kigoshi K, Kikkawa F

    Twin research and human genetics : the official journal of the International Society for Twin Studies   Vol. 15 ( 4 ) page: 547-9   2012.8

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    DOI: 10.1017/thg.2012.29

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  141. Establishment of a human nonluteinized granulosa cell line that transitions from the gonadotropin-independent to the gonadotropin-dependent status. Reviewed

    Bayasula, Iwase A, Kiyono T, Takikawa S, Goto M, Nakamura T, Nagatomo Y, Nakahara T, Kotani T, Kobayashi H, Kondo M, Manabe S, Kikkawa F

    Endocrinology   Vol. 153 ( 6 ) page: 2851-60   2012.6

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    DOI: 10.1210/en.2011-1810

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  142. Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptides. Reviewed

      Vol. 7 ( 8 ) page: e43745   2012

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    DOI: 10.1371/journal.pone.0043745

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  143. The loss of endoglin promotes the invasion of extravillous trophoblasts. Reviewed

    Mano Y, Kotani T, Shibata K, Matsumura H, Tsuda H, Sumigama S, Yamamoto E, Iwase A, Senga T, Kikkawa F

    Endocrinology   Vol. 152 ( 11 ) page: 4386-94   2011.11

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    DOI: 10.1210/en.2011-1088

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  144. Maternal mental disorders and pregnancy outcomes: a clinical study in a Japanese population. Reviewed

    Hironaka M, Kotani T, Sumigama S, Tsuda H, Mano Y, Hayakawa H, Tanaka S, Ozaki N, Tamakoshi K, Kikkawa F

    The journal of obstetrics and gynaecology research   Vol. 37 ( 10 ) page: 1283-9   2011.10

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    DOI: 10.1111/j.1447-0756.2010.01512.x

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  145. Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment. Reviewed

    Iwase A, Goto M, Manabe S, Hirokawa W, Kobayashi H, Nakahara T, Takikawa S, Kotani T, Sumigama S, Tsuda H, Nakayama T, Suzuki N, Matsushita T, Kikkawa F

    Fertility and sterility   Vol. 95 ( 6 ) page: 2124.e5-7   2011.5

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    DOI: 10.1016/j.fertnstert.2011.01.011

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  146. Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN). Reviewed

    Tsuda H, Takahashi Y, Iwagaki S, Uchida Y, Kawabata I, Hayakawa M, Sumigama S, Hayakawa H, Kotani T, Kikkawa F

    Journal of perinatal medicine   Vol. 39 ( 3 ) page: 245-50   2011.5

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    DOI: 10.1515/JPM.2011.006

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  147. Intra-amniotic infection increases amniotic lamellar body count before 34 weeks of gestation. Reviewed

    Tsuda H, Takahashi Y, Iwagaki S, Kawabata I, Hayakawa H, Kotani T, Shibata K, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 23 ( 10 ) page: 1230-6   2010.10

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    DOI: 10.3109/14767051003615442

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  148. Elevated levels of aldosterone in the amniotic fluid was observed in two cases of congenital mesoblastic nephroma. Reviewed

    Kotani T, Sumigama S, Hayakawa H, Mano Y, Tsuda H, Sugiyama C, Kawachi F, Hironaka M, Kato T, Kaneko K, Hayakawa M, Kikkawa F.

    Ultrasound Obstet Gynecol.   Vol. 36 ( 2 ) page: 256-8   2010.8

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  149. Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells. Reviewed

    Morimitsu A, Sumigama S, Kotani T, Mano Y, Suzuki K, Araki-Taguchi M, Yamamoto E, Hayakawa H, Okada M, Itakura A, Kikkawa F

    Gynecologic and obstetric investigation   Vol. 69 ( 1 ) page: 67-72   2010

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    DOI: 10.1159/000257663

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  150. *Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line Reviewed

    Kotani T, Iwase A, Ino K, Sumigama S, Yamamoto E, Hayakawa H, Nagasaka T, Itakura A, Nomura S, Kikkawa F

    Endocrinology   Vol. 150 ( 9 ) page: 4376-4385   2009.9

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    The reduced migration/invasion of extravillous trophoblasts (EVTs) is a key feature of the genesis of preeclampsia. We and others previously reported that transcriptional factors activator protein-2 (AP-2) alpha and AP-2gamma act as suppressors of tumor invasion. The present study examined the expressions of AP-2alpha and AP-2gamma in preeclamptic placenta vs. control placenta and investigated their effect on the function of EVTs. The expressions of AP-2alpha and AP-2gamma were elevated in the preeclamptic placentas in comparison with the gestational age-matched control placentas. Their expressions also increased in EVTs of the preeclamptic placentas. Thereafter, we transfected AP-2alpha or AP-2gamma into human EVT cell line, HTR-8/SVneo. The overexpression of AP-2alpha or AP-2gamma decreased the migratory and invasive abilities in HTR-8/SVneo cells. This was followed by the reduction of protease activated receptor-1 and matrix metalloproteinases and a significant induction of plasminogen activator inhibitor-1 and the tissue inhibitor of metalloproteinase-1. AP-2alpha and AP-2gamma were weakly expressed in the cultured EVTs and HTR-8/SVneo cells, whereas they were induced by TNF-alpha, which increases in preeclamptic placenta and impairs trophoblast invasion. In the presence of TNF-alpha, the invasion of the HTR-8/SVneo cells was partially restored by a blocking of AP-2 induction using small interfering RNA of AP-2. The present data suggest that AP-2 may suppress trophoblast migration and invasion, thus leading to a shallow placentation in preeclampsia.

  151. Placenta previa increta/percreta in Japan: a retrospective study of ultrasound findings, management and clinical course. Reviewed

    Sumigama S, Itakura A, Ota T, Okada M, Kotani T, Hayakawa H, Yoshida K, Ishikawa K, Hayashi K, Kurauchi O, Yamada S, Nakamura H, Matsusawa K, Sakakibara K, Ito M, Kawai M, Kikkawa F

    The journal of obstetrics and gynaecology research   Vol. 33 ( 5 ) page: 606-11   2007.10

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    DOI: 10.1111/j.1447-0756.2007.00619.x

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  152. Placental leucine aminopeptidase might regulate the effects of oxytocin with resolution in endothelial cells. Reviewed

    Sano M, Itakura A, Ito M, Takeuchi M, Okada M, Kotani T, Mizutani S, Kikkawa F

    Medical science monitor : international medical journal of experimental and clinical research   Vol. 11 ( 7 ) page: BR195-9   2005.7

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Books 10

  1. 今日の治療指針私はこう治療している2023

    ( Role: Contributor)

    2023.1 

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    Language:Japanese

  2. 治療法の再整理とアップデートのために 専門家による私の治療 産褥乳腺炎(解説)

    小谷友美( Role: Sole author)

    日本医事新報  2022.12 

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    Responsible for pages:50   Language:Japanese

  3. 【帝王切開分娩のすべて-この1冊でわかるNew Normal Standard】術式の工夫 子宮筋層縫合術の工夫 縫合不全・瘢痕部菲薄化の予防のために(解説)

    小谷友美 牛田貴文( Role: Joint author)

    2022.12 

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    Responsible for pages:1196-1201   Language:Japanese

    DOI: 10.11477/mf.1409210835

  4. 【生殖医療の安全性-どんなリスクと留意点があるのか?】受精卵,児・家族への影響 先天性心疾患と循環器系異常(解説)

    森本 美仁, 小谷 友美, 加藤 太一

    臨床婦人科産科  2022.11 

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    Responsible for pages:1123-1128   Language:Japanese

  5. 【産婦人科における素朴な疑問と解説(2)産科編】Rh式血液型不適合妊娠よりずっと頻度が高いABO式血液型不適合妊娠でトラブルが少ないのはなぜ?(解説)

    田野翔 小谷友美( Role: Joint author)

    産科と婦人科  2022.11 

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    Responsible for pages:1201-1205   Language:Japanese

  6. 【見て、聞いて、触って、身体所見から考える妊産褥婦の異常とその対応】帯下が多い、臭う(解説)

    松尾聖子 小谷友美( Role: Joint author)

    周産期医学   2022.8 

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    Responsible for pages:1145-1147   Language:Japanese

  7. 【子宮内膜症の最新知識-この1冊で重要ポイントを網羅する】周産期予後 子宮内膜症・子宮腺筋症女性における周産期合併症リスクの考察(解説)

    小谷友美 牛田貴文( Role: Joint author)

    2022.7 

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    Responsible for pages:670-675   Language:Japanese

    DOI: 10.11477/mf.1409210741

  8. 今日の治療指針私はこう治療している2022

    小谷友美( Role: Contributor ,  妊娠悪阻)

    医学書院  2022.1 

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    Responsible for pages:1381-1382  

  9. 胎児超音波診断を活かす-産科医と新生児科医からの情報提供-

    小谷友美、伊藤美春(胸腔内疾患 先天性横隔膜ヘルニア)

    周産期医学  2021.9 

  10. 【周産期の周辺を強化する-プレコンセプションケアと産後ケアの充実に向けて】

    小谷友美.(他科と連携したプレコンセプションケアと産後ケア 精神科医/心療内科医・公認心理師との連携 産婦人科から.)

    周産期医学  2021.4 

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Presentations 3

  1. 妊産婦の不安によりそう NIPTの運用  Invited

    小谷友美

    愛知県周産期協議会専門相談研修会  2023.3.9 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  2. 胎児期の管理 胎内炎症が神経発達に及ぼす影響 Invited

    小谷友美

    第1回超早産児神経発達症研究会セミナー   2022.9.25 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  3. メンタル不調の妊産婦さんへの支援を考える Invited

    小谷友美

    愛知県産婦人科医会 MCMC母と子のメンタルヘルス研修会(入門編)  2022.7.2 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

Research Project for Joint Research, Competitive Funding, etc. 2

  1. 妊娠高血圧症候群の成因へのエンドグリンの関与の解明

    2011.4

    神澤医学研究振興財団第15回研究助成金 

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    Grant type:Competitive

    妊娠高血圧症候群は、未だに母児ともに予後不良な疾患である。児は子宮内胎児発育遅延を合併し、新生児医
    療の進歩によりその生存率は改善したものの、脳障害などの後遺障害が問題となる。他方、母体では、HELLP
    症候群や脳血管障害といった重篤な合併症が問題となっている。脳血管障害は、我が国の妊産婦死亡原因の約
    25%を占めることが明らかとなり、その管理に関心が高まっている。病態は絨毛外絨毛細胞(EVT)の母体脱落
    膜への浸潤不全による胎盤低形成にあるとされるものの、未だ不明な点が多いために、有効な予防法や治療法
    が確立されていない。我々は、癌研究領域でのendoglinが細胞浸潤へ関与するという報告およびに妊娠高血圧
    症候群胎盤ではendoglin発現が増加するという報告に着目し、endoglinが胎盤低形成に関与しているという
    仮説をたてた。Endoglinが低酸素やTGF-といった胎盤低形成因子によって発現増加するという報告や、ラッ
    ト動物実験でその注入によりHELLP症候群モデルを作成したという報告もあり、本研究では、成因を解明する
    と同時に、重篤な合併症の発症予測・予防法を確立し、妊娠高血圧症候群の予後の向上を目指したい。

  2. 胎盤プロテアーゼとその転写因子AP-2からみた妊娠中毒症の病態解明と治療法の展開

    2002.4 - 2004.12

    財団法人 日母おぎゃー献金基金 

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    Grant type:Competitive

    転写因子が妊娠高血圧症候群の病態に関与しており、よりその機構を明らかにすることにより、妊娠高血圧症候群の発症予防にも応用できる可能性が示唆された

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 早産児の神経学的予後向上に向けた病態解明~腸脳相関に着目して~

    Grant number:22K09638  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    小谷 友美

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    近年、女性が多様な生き方を選択・実現できる社会へと変容し、晩産化や生殖補助医療による妊娠が増加している。さらに、食行動も変化している。これらの生活様式の変化は、妊娠高血圧腎症や早産など周産期合併症の発症リスクと関連する。本研究では、効率的な戦略として、妊娠前からの予防戦略を開発する。動物モデルや臨床検体を用いた解析を実施し、母体腸内細菌叢および関連する食行動などを統合的に理解する知見を確立し、最終的には、児の神経学的後遺症発症を防止する妊娠前からの介入法の開発を目指す。

  2. 新規自己抗体標的抗原に着目した自己免疫関連生殖機能障害の病態解明と早期診断法確立

    Grant number:20H03819  2020.4 - 2024.3

    岩瀬 明

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    Authorship:Coinvestigator(s) 

    不妊症・不育症には自己免疫疾患が合併することがあるが、その詳細は不明である。我々は患者血清中に存在する自己抗体とその標的タンパクProstate, ovary, testis, ankyrin domain family member F (POTEF)を同定した。POTEFは卵巣、胎盤に特異性高く発現し、自己免疫機序によるPOTEFの障害が卵巣機能不全、反復流産の病態であるという仮説をたてた。
    卵巣、胎盤におけるPOTEFの機能解析を行うとともに、抗POTE抗体をマウスに投与し、自己免疫機序による病態の再現が可能かどうか検証する。抗POTEF抗体のアッセイ系を用い臨床的検討もあわせて行う。

  3. Epigenetic change by perinatal inflammation and its regulation

    Grant number:17K11230  2017.4 - 2020.3

    KOTANI TOMOMI

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Preterm birth occurs by inflammation, and the fetus is affected by exposure to inflammation. In the present study, it was shown that exposure to inflammation in utero caused postnatal autism spectrum like findings, accompanied with several alterations in the brain tissues, amyglada, including microglial activation. Furthermore, some of the molecular mechanisms have been elucidated. In addition, as a preventive strategy against , the results suggesting that antenatal molecular hydrogen administration may prevent the development of postnatal neuropsychiatric disorders in preterm infants. Pregnant women with other inflammation related diseases will be also indicated as candidates for this preventive strategy, although further studies are needed.

  4. Interdisciplinary study of obstetric management and gynecological rare tumor in Vietnam

    Grant number:15H02660  2015.4 - 2020.3

    FUMITAKA KIKKAWA

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    Authorship:Coinvestigator(s) 

    For the purpose of not only the development of obstetrics and gynecology in Vietnam, but also creation of evidence worldwide and building of medical research resources to Japan, we investigated obstetric management and gynecological rare tumor in Vietnam at several facilities in Vietnam. In the present study, several findings, which are related to improvement of mothers and children's prognosis,were gained. First, Pregnancy with dengue fever causes thrombocytopenia, which is at risk of postpartum hemorrhage. Second, cesarean section scar pregnancy with an increase in cesarean section rate in Vietnam, could be managed by medication for only selected patients. Third, evaluation of cardiac function by ultrasound examination for fetal growth restriction would be beneficial. Lastly, we found that there was a high secondary rate after molar pregnancy in Vietnam and preventive measures might improve it.

  5. 早産児の後遺症発症の減少を目指して~分子状水素を用いた新規治療法の開発~

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

    小谷 友美

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    Authorship:Principal investigator 

  6. 妊娠高血圧症候群の病態機序へのスフィンゴシン1リン酸の関与の解明と治療への応用

    2008.4

    科学研究費補助金  基盤研究(C) 20599006

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    Authorship:Principal investigator 

    妊娠高血圧症候群の病態へのスフィンゴシン1リン酸(S1P)の関与を証明し、S1P受容体をターゲットとした新しい治療法を提示することを目的としている。現在では、妊娠高血圧症候群は絨毛外栄養膜細胞(extravillous trophoblast, EVT)の母体脱落膜への浸潤不全によって発症するという説が有力であり、本研究では、S1PのEVT浸潤機能に対する直接作用についてその分子機構まで解明する。また、S1Pの主な供給源は血球系であるとされているが、本研究では、脱落膜のスフィンゴシンキナーゼ(SK)により合成されたS1PがEVTをパラクラインに刺激しその浸潤を調節しているという仮説を証明する。S1PによるEVT浸潤調節の役割を証明した後、妊娠高血圧症候群症例におけるこれらの物質の発現を正常妊娠症例と比較検討する。さらに、新規免疫抑制薬FTY720をはじめとするS1P受容体作動薬の投与がEVT浸潤調節機構に及ぼす影響についてもその分子機構まで証明し、その治療的応用の可能性を提示していく。

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Teaching Experience (On-campus) 6

  1. 周産期ハイリスクケア論

    2023

  2. 出生前診断

    2022

  3. 胎盤形成のメカニズムと異常

    2022

  4. 母子感染の予防と治療・周産期メンタルヘルス

    2022

  5. 胎盤形成のメカニズムと異常

    2020

  6. 母子感染の予防と治療・周産期メンタルヘルス

    2020

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