Updated on 2025/03/24

写真a

 
KOTANI, Tomomi
 
Organization
Nagoya University Hospital Maternity and Perinatal Care Center Professor of hospital
Title
Professor of hospital
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 2002.3   名古屋大学 ) 

Research Interests 7

  1. preterm delovary

  2. preeclampsia

  3. invsion of trophoblast

  4. fetal development

  5. perinatal brain damage

  6. perinatal mental health

  7. Interconception care

Research Areas 1

  1. Others / Others  / perinatology

Current Research Project and SDGs 4

  1. 胎内炎症曝露が及ぼすエピジェネティック変化とその制御

  2. 妊産婦前向きコホート研究の成果を用いた要介入群の同定法と支援策の開発

  3. 新規自己抗体標的抗原に着目した自己免疫関連生殖機能障害の病態解明と早期診断法確立

  4. Maternal-fetal boundary surface environment strategy

Research History 1

  1. Nagoya University   Nagoya University Hospital Maternity and Perinatal Care Center   Associate professor

    2018.7

Education 1

  1. Nagoya University   Graduate School, Division of Medicine

    1999.4 - 2002.3

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    Country: Japan

Professional Memberships 1

  1. 日本産婦人科学会、日本周産期.新生児学会、日本胎盤学会、日本人類遺伝学会、日本内分泌学会

    2006.4 - 2010.3

Committee Memberships 1

  1. 産婦人科診療ガイドライン委員会   委員  

    2014.4 - 2017.3   

 

Papers 177

  1. Visualizing risk modification of hypertensive disorders of pregnancy: development and validation of prediction model for personalized interpregnancy weight management Reviewed

    Tano, S; Kotani, T; Ushida, T; Matsuo, S; Yoshihara, M; Imai, K; Kinoshita, F; Moriyama, Y; Nomoto, M; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    HYPERTENSION RESEARCH   Vol. 48 ( 3 ) page: 884 - 893   2025.3

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    DOI: 10.1038/s41440-024-02024-8

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  2. Motor and functional characteristics in school-age survivors of congenital diaphragmatic hernia: a cross-sectional observational study Reviewed

    Mitsumatsu, T; Ito, Y; Muramatsu, Y; Sato, Y; Ito, T; Narahara, S; Miura, R; Yamamoto, H; Ito, M; Shiraki, A; Nakata, T; Kotani, T; Natsume, J; Hayakawa, M; Takahashi, Y; Kidokoro, H

    ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION     2025.2

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  3. Dietary supplements and prevention of preeclampsia Reviewed

    Ushida, T; Tano, S; Matsuo, S; Fuma, K; Imai, K; Kajiyama, H; Kotani, T

    HYPERTENSION RESEARCH     2025.2

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    DOI: 10.1038/s41440-025-02144-9

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  4. Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders Reviewed

    Fuma, K; Iitani, Y; Imai, K; Ushida, T; Tano, S; Yoshida, K; Yokoi, A; Miki, R; Kidokoro, H; Sato, Y; Hara, Y; Ogi, T; Nomaki, K; Tsuda, M; Komine, O; Yamanaka, K; Kajiyama, H; Kotani, T

    COMMUNICATIONS BIOLOGY   Vol. 8 ( 1 ) page: 75   2025.1

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    Authorship:Last author, Corresponding author   Language:English  

    DOI: 10.1038/s42003-025-07511-3

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  5. Effect of Cytokine Concentrations on Long-term Neurological Outcomes in Fetal Pleural Effusion Managed with Thoracoamniotic Shunt. Reviewed

    Imai K, Tano S, Fuma K, Matsuo S, Ushida T, Kajiyama H, Kotani T

    JMA journal   Vol. 8 ( 1 ) page: 288 - 292   2025.1

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    DOI: 10.31662/jmaj.2024-0227

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  6. Patient awareness of long-term cardiovascular and metabolic disease risks after hypertensive disorders of pregnancy in Japan Reviewed

    Ushida, T; Tano, S; Matsuo, S; Fuma, K; Imai, K; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 51 ( 1 ) page: e16183   2025.1

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    DOI: 10.1111/jog.16183

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  7. Assisted reproductive technology and prolonged third stage of labour: a multicentre study in Japan Reviewed

    Kato, A; Ushida, T; Matsuo, S; Tano, S; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    REPRODUCTIVE BIOMEDICINE ONLINE   Vol. 49 ( 6 ) page: 104382   2024.12

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    DOI: 10.1016/j.rbmo.2024.104382

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  8. Impact of antenatal corticosteroids on subcortical volumes in preterm infants at term-equivalent age: A retrospective observational study Reviewed

    Fuma, K; Ushida, T; Kawaguchi, M; Nosaka, R; Kidokoro, H; Tano, S; Imai, K; Sato, Y; Hayakawa, M; Kajiyama, H; Kotani, T

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 302   page: 7 - 14   2024.11

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    DOI: 10.1016/j.ejogrb.2024.08.034

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  9. Elevated levels of apolipoprotein A4 in umbilical cord serum from the maternal major depressive disorder Reviewed

    Matsuo, S; Moriyama, Y; Ushida, T; Imai, K; Tano, S; Miki, R; Yoshida, K; Yokoi, A; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 11 ) page: 2038 - 2045   2024.11

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    DOI: 10.1111/jog.16096

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  10. Association between combined use of epidural analgesia and oxytocin administration during labor and offspring outcomes: a narrative review and proposal Reviewed

    Tachi, A; Takahashi, Y; Kotani, T

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 86 ( 4 ) page: 549 - 563   2024.11

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    DOI: 10.18999/nagjms.86.4.549

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  11. Possible Efficacy of Vaginal Progesterone on Asymptomatic Women with a Short Cervix after 24 Weeks of Gestation: A Historical Cohort Study in Japan Reviewed

    Otsuka, N; Imai, K; Tano, S; Matsuo, S; Ushida, T; Nomoto, M; Iitani, Y; Ishi, M; Kawai, Y; Furui, T; Kajiyama, H; Kotani, T

    JMA JOURNAL   Vol. 7 ( 4 ) page: 582 - 589   2024.10

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    DOI: 10.31662/jmaj.2024-0036

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  12. Effect of chorioamnionitis on postnatal growth in very preterm infants: a population-based study in Japan Reviewed

    Ushida, T; Nosaka, R; Nakatochi, M; Kobayashi, Y; Tano, S; Fuma, K; Matsuo, S; Imai, K; Sato, Y; Hayakawa, M; Kajiyama, H; Kotani, T; Neonatal Res Network Japan

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS     2024.10

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    DOI: 10.1007/s00404-024-07757-y

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  13. Impact of antenatal corticosteroids-to-delivery interval on very preterm neonatal outcomes: a retrospective study in two tertiary centers in Japan Reviewed

    Fuma, K; Kotani, T; Tsuda, H; Oshiro, M; Tano, S; Ushida, T; Imai, K; Sato, Y; Kajiyama, H

    BMC PREGNANCY AND CHILDBIRTH   Vol. 24 ( 1 ) page: 607   2024.9

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    Authorship:Corresponding author   Language:English  

    DOI: 10.1186/s12884-024-06790-8

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  14. TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta Reviewed

    Miki, R; Matsuo, S; Ushida, T; Tano, S; Imai, K; Nawa, A; Kajiyama, H; Kotani, T

    MOLECULAR AND CELLULAR ENDOCRINOLOGY   Vol. 591   page: 112277   2024.9

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    DOI: 10.1016/j.mce.2024.112277

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  15. Educational results of the Japan Maternal Emergency Life-Saving (J-MELS) simulation training organized by Japan Council for the Implementation of the Maternal Emergency Life-Saving System (J-CIMELS): a 12-month longitudinal follow-up study in Japan Reviewed

    Imai, K; Hashimoto, Y; Ito, Y; Sakata, K; Kawanami, M; Nakano-Kobayashi, T; Hashii, K; Yamahata, Y; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 9 ) page: 1513 - 1521   2024.9

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    DOI: 10.1111/jog.16011

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  16. Identifying the high-benefit population for weight management-based cardiovascular disease prevention in Japan Reviewed

    Tano, S; Kotani, T; Matsuo, S; Ushida, T; Imai, K; Kajiyama, H

    PREVENTIVE MEDICINE REPORTS   Vol. 43   page: 102782   2024.7

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    Authorship:Corresponding author   Language:English  

    DOI: 10.1016/j.pmedr.2024.102782

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  17. Postpartum and interpregnancy care of women with a history of hypertensive disorders of pregnancy Reviewed

    Ushida, T; Tano, S; Imai, K; Matsuo, S; Kajiyama, H; Kotani, T

    HYPERTENSION RESEARCH   Vol. 47 ( 6 ) page: 1457 - 1469   2024.6

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    DOI: 10.1038/s41440-024-01641-7

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  18. Amniotic fluid-derived small extracellular vesicles for predicting postnatal severe outcome of congenital diaphragmatic hernia. Reviewed

    Matsuo S, Yokoi A, Yoshida K, Kitagawa M, Asano-Inami E, Miura M, Yasui T, Tano S, Ushida T, Imai K, Kajiyama H, Kotani T

    Journal of extracellular biology   Vol. 3 ( 6 ) page: e160   2024.6

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    DOI: 10.1002/jex2.160

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  19. Intrauterine exposure to chorioamnionitis and neuroanatomical alterations at term-equivalent age in preterm infants Reviewed

    Nosaka, R; Ushida, T; Kidokoro, H; Kawaguchi, M; Shiraki, A; Iitani, Y; Imai, K; Nakamura, N; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 309 ( 5 ) page: 1909 - 1918   2024.5

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    DOI: 10.1007/s00404-023-07064-y

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  20. Predictive performance of Shock Index for postpartum hemorrhage during cesarean delivery Reviewed

    Mizutani, H; Ushida, T; Ozeki, K; Tano, S; Iitani, Y; Imai, K; Nishiwaki, K; Kajiyama, H; Kotani, T

    INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA   Vol. 58   page: 103957   2024.5

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    DOI: 10.1016/j.ijoa.2023.103957

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  21. Importance of the time sequence between measurement of the predictor and of the predicted outcome: Response Invited

    Mizutani, H; Ushida, T; Kajiyama, H; Kotani, T

    INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA   Vol. 58   page: 103995   2024.5

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    DOI: 10.1016/j.ijoa.2024.103995

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  22. Practical weight management to minimize pregnancy complications and promote women's health: the possibility of interpregnancy care Invited

    Kotani, T; Tano, S; Ushida, T; Imai, K; Kajiyama, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 86 ( 2 ) page: 160 - 168   2024.5

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    DOI: 10.18999/nagjms.86.2.160

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  23. Predicting preterm birth within 2 weeks in asymptomatic women with a short cervix: Combined effects of cervicovaginal fluid cytokine levels and fetal fibronectin test Reviewed

    Ohori, Y; Imai, K; Tano, S; Owaki, T; Miki, R; Nozaki, Y; Ushida, T; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 4 ) page: 587 - 595   2024.4

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    DOI: 10.1111/jog.15889

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  24. 分娩中人工羊水注入を実施した7例についての検討 当院における新たな取り組み Invited Reviewed

    鬼頭 まり, 田野 翔, 松尾 聖子, 牛田 貴文, 今井 健史, 小谷 友美, 梶山 広明

    東海産科婦人科学会雑誌     2024.3

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    Language:Japanese  

  25. Interleukin-17A stimulation induces alterations in Microglial microRNA expression profiles Reviewed

    Iitani, Y; Miki, R; Imai, K; Fuma, K; Ushida, T; Tano, S; Yoshida, K; Yokoi, A; Kajiyama, H; Kotani, T

    PEDIATRIC RESEARCH   Vol. 95 ( 1 ) page: 167 - 173   2024.1

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    DOI: 10.1038/s41390-023-02825-6

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  26. Risk factors for non-previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan

    Matsuo, S; Kotani, T; Tano, S; Ushida, T; Imai, K; Nakamura, T; Osuka, S; Goto, M; Osawa, M; Asada, Y; Kajiyama, H

    REPRODUCTIVE MEDICINE AND BIOLOGY   Vol. 23 ( 1 ) page: e12592   2024.1

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  27. Antenatal prediction models for outcomes of extremely and very preterm infants based on machine learning. Reviewed

    Ushida T, Kotani T, Baba J, Imai K, Moriyama Y, Nakano-Kobayashi T, Iitani Y, Nakamura N, Hayakawa M, Kajiyama H, Neonatal Research Network of Japan

    Archives of gynecology and obstetrics   Vol. 308 ( 6 ) page: 1755 - 1763   2023.12

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  28. New-onset postpartum hypertension in women without a history of hypertensive disorders of pregnancy: a multicenter study in Japan Reviewed

    Ushida, T; Nakamura, N; Katsuki, S; Mizutani, H; Iitani, Y; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    HYPERTENSION RESEARCH   Vol. 46 ( 12 ) page: 2583 - 2592   2023.12

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    DOI: 10.1038/s41440-023-01372-1

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  29. Sex-specific differences in head circumference of term singletons after assisted reproductive technology: a multicentre study in Japan Reviewed

    Matsuo, S; Ushida, T; Tano, S; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    REPRODUCTIVE BIOMEDICINE ONLINE   Vol. 47 ( 6 ) page: 103331   2023.12

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    DOI: 10.1016/j.rbmo.2023.103331

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  30. Long-term effects of gestational weight gain on mortality Invited

    Kotani, T; Tano, S

    LANCET   Vol. 402 ( 10415 ) page: 1809 - 1811   2023.11

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    DOI: 10.1016/S0140-6736(23)01837-8

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  31. Antenatal corticosteroids and outcomes of small for gestational age infants born at 24-31 gestational weeks: a population-based propensity score matching analysis Reviewed

    Ushida, T; Nakatochi, M; Kobayashi, Y; Nakamura, N; Fuma, K; Iitani, Y; Imai, K; Sato, Y; Hayakawa, M; Kajiyama, H; Kotani, T; Japan, NRNO

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 308 ( 5 ) page: 1463 - 1471   2023.11

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00404-022-06834-4

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  32. Comparison of the efficacy between controlled-release dinoprostone delivery system (PROPESS) and Cook's double balloon catheter plus oxytocin: A retrospective single-center study in Japan Reviewed

    Imai, K; Nozaki, Y; Ushida, T; Tano, S; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 9 ) page: 2317 - 2323   2023.9

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    DOI: 10.1111/jog.15734

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  33. The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset Reviewed

    Yoshihara, M; Mizutani, S; Matsumoto, K; Kato, Y; Masuo, Y; Harumasa, A; Iyoshi, S; Tano, S; Mizutani, H; Kotani, T; Mizutani, E; Shibata, K; Kajiyama, H

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X   Vol. 19   page: 100210   2023.9

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  34. Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model Reviewed

    Nakamura, N; Ushida, T; Onoda, A; Ueda, K; Miura, R; Suzuki, T; Katsuki, S; Mizutani, H; Yoshida, K; Tano, S; Iitani, Y; Imai, K; Hayakawa, M; Kajiyama, H; Sato, Y; Kotani, T

    FRONTIERS IN PEDIATRICS   Vol. 11   page: 1168173   2023.7

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    DOI: 10.3389/fped.2023.1168173

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  35. Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study Reviewed

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakamura, N; Iitani, Y; Moriyama, Y; Emoto, R; Kato, S; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Matsui, S; Kajiyama, H

    DIABETOLOGY & METABOLIC SYNDROME   Vol. 15 ( 1 ) page: 123   2023.6

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    DOI: 10.1186/s13098-023-01103-z

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  36. Clinical significances of Bishop score and vaginal bleeding to controlled-release dinoprostone delivery system (PROPESS) efficacy for cervical ripening: A retrospective single-center study in Japan. Reviewed

    The journal of obstetrics and gynaecology research   Vol. 49 ( 4 ) page: 1154 - 1160   2023.4

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    DOI: 10.1111/jog.15575

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  37. Antenatal corticosteroids-to-delivery interval associates cord blood S100B levels. Reviewed

    The journal of obstetrics and gynaecology research   Vol. 49 ( 4 ) page: 1129 - 1136   2023.4

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    DOI: 10.1111/jog.15582

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  38. Trend changes in age-related body mass index gain after coronavirus disease 2019 pandemic in Japan: a multicenter retrospective cohort study. Reviewed

    Reproductive biology and endocrinology : RB&E   Vol. 21 ( 1 ) page: 7   2023.1

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    DOI: 10.1186/s12958-023-01061-1

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  39. Prenatal diagnosis of distal 13q deletion syndrome in a fetus with esophageal atresia: a case report and review of the literature. Reviewed

    Journal of medical case reports   Vol. 16 ( 1 ) page: 481   2022.12

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  40. Aberrant inflammation in rat pregnancy leads to cardiometabolic alterations in their offspring and intrauterine growth restriction in the F2 generation Reviewed International coauthorship

    Ushida, T; Cotechini, T; Protopapas, N; Atallah, A; Collyer, C; Toews, AJ; Macdonald-Goodfellow, SK; Tse, MY; Winn, LM; Pang, SC; Adams, MA; Othman, M; Kotani, T; Kajiyama, H; Graham, CH

    JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE   Vol. 13 ( 6 ) page: 706 - 718   2022.12

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  41. A case of non-immune hydrops fetalis with maternal mirror syndrome diagnosed by trio-based exome sequencing: An autopsy case report and literature review. Reviewed

    Molecular genetics and metabolism reports   Vol. 33   page: 100925   2022.12

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  42. Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells Reviewed

    Aoki, C; Imai, K; Mizutani, T; Sugiyama, D; Miki, R; Koya, Y; Kobayashi, T; Ushida, T; Iitani, Y; Nakamura, N; Owaki, T; Nishikawa, H; Toyokuni, S; Kajiyama, H; Kotani, T

    LIFE SCIENCES   Vol. 308   page: 120955   2022.11

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    DOI: 10.1016/j.lfs.2022.120955

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  43. Optimal annual body mass index change for preventing spontaneous preterm birth in a subsequent pregnancy. Reviewed

    Scientific reports   Vol. 12 ( 1 ) page: 17502   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-22495-4

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  44. 5p deletion with congenital diaphragmatic hernia: a case report Reviewed

    Kotani, T; Ushida, T; Nakamura, N; Imai, K; Iitani, Y; Tano, S; Iwagaki, S; Takahashi, Y; Ito, M; Hayakawa, M; Kajiyama, H

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 16 ( 1 ) page: 390   2022.10

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  45. Severe Congenital Diaphragmatic Hernia With Trisomy 9: A Case Report and Review of the Literature

    Fuma, K; Kotani, T; Nakamura, N; Ushida, T; Kajiyama, H

    CUREUS JOURNAL OF MEDICAL SCIENCE   Vol. 14 ( 8 ) page: e28395   2022.8

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  46. Impact of hypertensive disorders of pregnancy on respiratory outcomes in extremely and very preterm infants: A population-based study in Japan Reviewed

    Ushida, T; Nakamura, N; Nakatochi, M; Kobayashi, Y; Sato, Y; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H; Kotani, T

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 29   page: 54 - 60   2022.8

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    DOI: 10.1016/j.preghy.2022.06.003

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  47. Reassessing the duration of each stage of labor and their relation to postpartum hemorrhage in the current Japanese population Reviewed

    Ushida, T; Matsuo, S; Nakamura, N; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1760 - 1767   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15280

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  48. Machine learning prediction models for postpartum depression: A multicenter study in Japan Reviewed

    Matsuo, S; Ushida, T; Emoto, R; Moriyama, Y; Iitani, Y; Nakamura, N; Imai, K; Nakano-Kobayashi, T; Yoshida, S; Yamashita, M; Matsui, S; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1775 - 1785   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15266

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  49. The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia Reviewed

    Aoki, C; Imai, K; Owaki, T; Kobayashi-Nakano, T; Ushida, T; Iitani, Y; Nakamura, N; Kajiyama, H; Kotani, T

    MEDICINA-LITHUANIA   Vol. 58 ( 6 )   2022.6

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    DOI: 10.3390/medicina58060731

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  50. Intrauterine exposure to hypertensive disorders of pregnancy and postnatal growth in extremely and very preterm infants Reviewed

    Ushida, T; Kotani, T; Nakatochi, M; Kobayashi, Y; Nakamura, N; Imai, K; Iitani, Y; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 28   page: 174 - 179   2022.6

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    DOI: 10.1016/j.preghy.2022.05.007

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  51. Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb) Reviewed

    Maki, S; Tanaka, H; Takakura, S; Nii, M; Tanaka, K; Ogura, T; Kotera, M; Nishimura, Y; Tamaru, S; Ushida, T; Tanaka, Y; Kikuchi, N; Kinjo, T; Kawamura, H; Takano, M; Nakamura, K; Suga, S; Kasai, M; Yasui, O; Nagao, K; Maegawa, Y; Kotani, T; Endo, M; Yasuhi, I; Aoki, S; Aoki, Y; Yoshida, Y; Nakata, M; Sekizawa, A; Ikeda, T

    BMJ OPEN   Vol. 12 ( 6 ) page: e054925   2022.6

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  52. Prevalence of common aneuploidy in twin pregnancies Reviewed

    Konishi, A; Samura, O; Muromoto, J; Okamoto, Y; Takahashi, H; Kasai, Y; Ichikawa, M; Yamada, N; Kato, N; Sato, H; Hamada, H; Nakanami, N; Machi, M; Ichizuka, K; Sunami, R; Tanaka, T; Yonetani, N; Kamei, Y; Nagamatsu, T; Matsumoto, M; Tairaku, S; Fujiwara, A; Nakamura, H; Harada, T; Watanabe, T; Sasaki, S; Kawaguchi, S; Minami, S; Ogawa, M; Miura, K; Suzumori, N; Kojima, J; Kotani, T; Sasaki, R; Baba, T; Toyofuku, A; Endo, M; Takeshita, N; Taketani, T; Sase, M; Matsubara, K; Hayata, K; Hamada, Y; Egawa, M; Kakinuma, T; Matsushima, S; Kitagawa, M; Shiga, T; Kurashina, R; Hamada, H; Takagi, H; Kondo, A; Miharu, N; Yamashita, M; Horiya, M; Morimoto, K; Takahashi, K; Okamoto, A; Sekizawa, A; Sago, H

    JOURNAL OF HUMAN GENETICS   Vol. 67 ( 5 ) page: 261 - 265   2022.5

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    DOI: 10.1038/s10038-021-01001-0

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  53. Pregnancy Outcomes in Women with Thyroid Diseases Reviewed

    Kotani, T; Imai, K; Ushida, T; Moriyama, Y; Nakano-Kobayashi, T; Osuka, S; Tsuda, H; Sumigama, S; Yamamoto, E; Kinoshita, F; Hirakawa, A; Iwase, A; Kikkawa, F; Kajiyama, H

    JMA JOURNAL   Vol. 5 ( 2 ) page: 216 - 223   2022.4

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    DOI: 10.31662/jmaj.2021-0191

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  54. Assessment of placental abruption with diffusion-weighted imaging Reviewed

    Mizutani, T; Kotani, T; Kato, N; Imai, K; Ushida, T; Nakano-Kobayashi, T; Kinoshita, Y; Ito, M; Kinoshita, F; Yamamuro, O; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 4 ) page: 930 - 937   2022.4

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  55. Crosstalk between foetal vasoactive peptide hormones and placental aminopeptidases regulates placental blood flow: Its significance in preeclampsia Reviewed

    Yoshihara, M; Mizutani, S; Matsumoto, K; Kato, Y; Masuo, Y; Tano, S; Mizutani, H; Kotani, T; Mizutani, E; Shibata, K; Kajiyama, H

    PLACENTA   Vol. 121   page: 32 - 39   2022.4

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  56. Annual Body Mass Index Gain and Risk of Gestational Diabetes Mellitus in a Subsequent Pregnancy

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Iitani, Y; Kinoshita, F; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    FRONTIERS IN ENDOCRINOLOGY   Vol. 13   page: 815390   2022.3

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  57. Effects of evidence-based ICU care on long-term outcomes of patients with sepsis or septic shock (ILOSS): protocol for a multicentre prospective observational cohort study in Japan

    Liu, KB; Kotani, T; Nakamura, K; Chihiro, T; Morita, Y; Ishii, K; Fujizuka, K; Yasumura, D; Taniguchi, D; Hamagami, T; Shimojo, N; Nitta, M; Hongo, T; Akieda, K; Atsuo, M; Kaneko, T; Sakuda, Y; Andoh, K; Nagatomi, A; Tanaka, Y; Irie, Y; Kamijo, H; Hanazawa, M; Kasugai, D; Ayaka, M; Oike, K; Lefor, AK; Takahashi, K; Katsukawa, H; Ogura, T

    BMJ OPEN   Vol. 12 ( 3 ) page: e054478   2022.3

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  58. Pre-pregnancy sleep duration and postpartum depression: a multicenter study in Japan Reviewed

    Matsuo, S; Ushida, T; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    ARCHIVES OF WOMENS MENTAL HEALTH   Vol. 25 ( 1 ) page: 181 - 189   2022.2

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  59. Clinical guide for women with mental health problems during the perinatal period Reviewed

    Shimoya, K; Kotani, T; Satoh, S; Suzuki, S; Kashima, H; Ogasawara, K; Ozaki, N; Suzuki, E; Tachibana, Y; Suzuki, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 1 ) page: 20 - 33   2022.1

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  60. Liver transaminase levels during pregnancy: a Japanese multicenter study

    Ushida, T; Kotani, T; Kinoshita, F; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE   Vol. 35 ( 25 ) page: 5761 - 5767   2022

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  61. Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study Reviewed

    Katsuki, S; Ushida, T; Kidokoro, H; Nakamura, N; Iitani, Y; Fuma, K; Imai, K; Nakano-Kobayashi, T; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    EARLY HUMAN DEVELOPMENT   Vol. 163   page: 105479   2021.12

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  62. 高次医療機関における母体血を用いた出生前遺伝学的検査導入前後での羊水染色体検査状況の検討 Reviewed

    橋本 佑樹, 村松 友佳子, 伊藤 美春, 齊藤 明子, 佐藤 義朗, 牛田 貴文, 小谷 友美, 早川 昌弘

    日本周産期・新生児医学会誌     2021.12

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  63. Stepwise Treatment for Abnormally Invasive Placenta with Placenta Previa Reviewed

    Sumigama, S; Kotani, T; Hayakawa, H

    SURGERY JOURNAL   Vol. 07 ( Suppl 1 ) page: S20 - S27   2021.12

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  64. Prevalence and risk factors of labor-onset hypertension: A multicenter study in Japan Reviewed

    Ushida, T; Kotani, T; Imai, K; Nakano-Kobayashi, T; Iitani, Y; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 26   page: 48 - 53   2021.12

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  65. Annual body mass index gain and risk of hypertensive disorders of pregnancy in a subsequent pregnancy Reviewed

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Iitani, Y; Kinoshita, F; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 22519   2021.11

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  66. Tadalafil treatment for preeclampsia (medication in preeclampsia; MIE): a multicenter phase II clinical trial

    Furuhashi, F; Tanaka, H; Maki, S; Tsuji, M; Magawa, S; Kaneda, MK; Nii, M; Tanaka, K; Ogura, T; Nishimura, Y; Endoh, M; Kimura, T; Kotani, T; Sekizawa, A; Ikeda, T

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE   Vol. 34 ( 22 ) page: 3709 - 3715   2021.11

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  67. Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction Reviewed

    Nomoto, M; Kotani, T; Miki, R; Ushida, T; Imai, K; Iitani, Y; Tano, S; Wang, JW; Moriyama, Y; Kobayashi, T; Mimura, N; Iriyama, T; Kikkawa, F; Kajiyama, H

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 69 ( 3 ) page: 280 - 285   2021.11

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  68. Manual removal of the placenta and postpartum hemorrhage: A multicenter retrospective study Reviewed

    Fujita, K; Ushida, T; Imai, K; Nakano-Kobayashi, T; Iitani, Y; Matsuo, S; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 11 ) page: 3867 - 3874   2021.11

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  69. Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia Reviewed

    Miura, M; Imai, K; Tsuda, H; Miki, R; Tano, S; Ito, Y; Hirako-Takamura, S; Moriyama, Y; Ushida, T; Iitani, Y; Nakano-Kobayashi, T; Toyokuni, S; Kajiyama, H; Kotani, T

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 22 ( 17 )   2021.9

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  70. Current Issues within the Perinatal Mental Health Care System in Aichi Prefecture, Japan: A Cross-Sectional Questionnaire Survey Reviewed

    Fujita, K; Kotani, T; Moriyama, Y; Ushida, T; Imai, K; Kobayashi-Nakano, T; Kato, N; Kano, T; Kikkawa, F; Kajiyama, H

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH   Vol. 18 ( 17 )   2021.9

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  71. Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study Reviewed

    Ushida, T; Kidokoro, H; Nakamura, N; Katsuki, S; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 25   page: 143 - 149   2021.8

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  72. Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia. Reviewed International coauthorship

    Deprest JA, Nicolaides KH, Benachi A, Gratacos E, Ryan G, Persico N, Sago H, Johnson A, Wielgoś M, Berg C, Van Calster B, Russo FM; TOTAL Trial for Severe Hypoplasia Investigators.

    N Engl J Med   Vol. 385 ( 2 ) page: 107 - 118   2021.7

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  73. Antenatal prediction models for short- and medium-term outcomes in preterm infants

    Ushida, T; Moriyama, Y; Nakatochi, M; Kobayashi, Y; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Hayakawa, M; Kajiyama, H; Kotani, T

    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA   Vol. 100 ( 6 ) page: 1089 - 1096   2021.6

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    DOI: 10.1111/aogs.14136

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  74. Platelet counts during normal pregnancies and pregnancies complicated with hypertensive disorders Reviewed

    Ushida, T; Kotani, T; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Kinoshita, F; Nakamura, N; Iitani, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 24   page: 73 - 78   2021.6

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  75. Assessment of myocardial performance index in late-onset fetal growth restriction Reviewed International coauthorship

    Nguyen, TTN; Kotani, T; Imai, K; Ushida, T; Moriyama, Y; Kobayashi, T; Niimi, K; Sumigama, S; Yamamoto, E; Vo, VD; Le, MT; Le, LH; Nguyen, DN; Nguyen, VQH; Truong, QV; Cao, NT; Kikkawa, F

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 2 ) page: 259 - 268   2021.5

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  76. Postpartum alterations following inflammation in rat pregnancy: a discovery proteomic analysis Reviewed International coauthorship

    Ushida, T; Kotani, T; Moriyama, Y; Hindmarch, CCT; Cotechini, T; Imai, K; Nakano-Kobayashi, T; Kajiyama, H; Graham, CH

    REPRODUCTION   Vol. 161 ( 5 ) page: 513 - 522   2021.5

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  77. Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia

    Ito, Y; Tsuda, H; Imai, K; Miki, R; Miura, M; Tachi, A; Tano, S; Hirako-Takamura, S; Moriyama, Y; Ushida, T; Kobayashi, T; Sumigama, S; Kajiyama, H; Kikkawa, F; Kotani, T

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 700   page: 108769   2021.3

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  78. Trisomy 5p with bilateral congenital diaphragmatic hernia: a case report

    Nakamura, N; Ushida, T; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Osuka, S; Goto, M; Kajiyama, H; Asada, H; Hayakawa, M; Kotani, T

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 15 ( 1 ) page: 114   2021.3

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  79. Maternal low birth weight and hypertensive disorders of pregnancy

    Ushida, T; Kotani, T; Kinoshita, F; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 23   page: 5 - 10   2021.3

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  80. Shock Index and Postpartum Hemorrhage in Vaginal Deliveries: A Multicenter Retrospective Study

    Ushida, T; Kotani, T; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H; Kikkawa, F

    SHOCK   Vol. 55 ( 3 ) page: 332 - 337   2021.3

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  81. Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage

    Owaki, T; Imai, K; Miki, R; Niwa, Y; Kotani, T; Nakano-Kobayashi, T; Ushida, T; Kajiyama, H

    CYTOKINE   Vol. 138   page: 155406   2021.2

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  82. Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy

    Nakamura, N; Ushida, T; Nakatochi, M; Kobayashi, Y; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H; Kikkawa, F; Kotani, T

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 1729   2021.1

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  83. Very Low Levels of Serum Anti-Mullerian Hormone as a Possible Marker for Follicle Growth in Patients with Primary Ovarian Insufficiency Under Hormone Replacement Therapy

    Kasahara, Y; Osuka, S; Bayasula; Nakanishi, N; Murase, T; Nakamura, T; Goto, M; Kotani, T; Iwase, A; Kikkawa, F

    REPRODUCTIVE SCIENCES   Vol. 28 ( 1 ) page: 31 - 36   2021.1

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  84. Feasibility and outcomes of fetoscopic endoluminal tracheal occlusion for severe congenital diaphragmatic hernia: A Japanese experience

    Wada, S; Ozawa, K; Sugibayashi, R; Suyama, F; Amari, S; Ito, Y; Kanamori, Y; Okuyama, H; Usui, N; Sasahara, J; Kotani, T; Hayakawa, M; Kato, K; Taguchi, T; Endo, M; Sago, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 46 ( 12 ) page: 2598 - 2604   2020.12

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  85. Focal Adhesion Kinase-Mediated Sequences, Including Cell Adhesion, Inflammatory Response, and Fibrosis, as a Therapeutic Target in Endometriosis

    Nagai, T; Ishida, C; Nakamura, T; Iwase, A; Mori, M; Murase, T; Bayasula; Osuka, S; Takikawa, S; Goto, M; Kotani, T; Kikkawa, F

    REPRODUCTIVE SCIENCES   Vol. 27 ( 7 ) page: 1400 - 1410   2020.7

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  86. Antenatal corticosteroids and preterm offspring outcomes in hypertensive disorders of pregnancy: A Japanese cohort study

    Ushida, T; Kotani, T; Hayakawa, M; Hirakawa, A; Sadachi, R; Nakamura, N; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Kikkawa, F

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 9312   2020.6

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  87. Antenatal Corticosteroids and Outcomes in Preterm Twins

    Ushida, T; Kotani, T; Sadachi, R; Hirakawa, A; Hayakawa, M; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Kikkawa, F

    OBSTETRICS AND GYNECOLOGY   Vol. 135 ( 6 ) page: 1387 - 1397   2020.6

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  88. A proteome signature of umbilical cord serum associated with congenital diaphragmatic hernia

    Tachi, A; Moriyama, Y; Tsuda, H; Miki, R; Ushidai, T; Miura, M; Ito, Y; Imail, K; Nakano-Kobayashi, I; Hayakawa, M; Kikkawa, F; Kotani, T

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 345 - 354   2020.5

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  89. The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study.

    Yamamoto E, Trinh TD, Sekiya Y, Tamakoshi K, Nguyen XP, Nishino K, Niimi K, Kotani T, Kajiyama H, Shibata K, Le QT, Kikkawa F

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 183 - 191   2020.5

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    DOI: 10.18999/nagjms.82.2.183

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  90. Determination of the cytokine levels in fetal pleural effusion and their association with fetal/neonatal findings

    Imai, K; Kotani, T; Tsuda, H; Kobayashi, T; Ushida, T; Moriyama, Y; Kikkawa, F

    CYTOKINE   Vol. 127   page: 154945   2020.3

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  91. Two-photon microscopic observation of cell-production dynamics in the developing mammalian neocortex in utero

    Kawasoe, R; Shinoda, T; Hattori, Y; Nakagawa, M; Pham, TQ; Tanaka, Y; Sagou, K; Saito, K; Katsuki, S; Kotani, T; Sano, A; Fujimori, T; Miyata, T

    DEVELOPMENT GROWTH & DIFFERENTIATION   Vol. 62 ( 2 ) page: 118 - 128   2020.2

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  92. Outcome of cesarean scar pregnancy treated with local methotrexate injection

    Tam, LM; Kotani, T; Linh, TM; Thu, PTM; Khanh, TV; Anh, NTK; Nguyen, NTT; Moriyama, Y; Yamamoto, E; Huy, NVQ; Vinh, TQ; Thanh, CN; Kikkawa, F

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 1 ) page: 15 - 23   2020.2

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  93. The efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide and actinomycin D in patients with choriocarcinoma and high-risk gestational trophoblastic neoplasia

    Sato, S; Yamamoto, E; Niimi, K; Ino, K; Nishino, K; Suzuki, S; Kotani, T; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 203 - 209   2020.1

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  94. Adverse effects of endometriosis on pregnancy: a case-control study

    Miura, M; Ushida, T; Imai, K; Wang, JW; Moriyama, Y; Nakano-Kobayashi, T; Osuka, S; Kikkawa, F; Kotani, T

    BMC PREGNANCY AND CHILDBIRTH   Vol. 19 ( 1 ) page: 373   2019.10

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  95. A pitfall in diagnosing fetal abdominal lymphangioma: A report of two cases.

    Niwa Y, Imai K, Kotani T, Nakano T, Ushida T, Moriyama Y, Kikkawa F

    Journal of clinical ultrasound : JCU   Vol. 47 ( 8 ) page: 494 - 496   2019.10

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    DOI: 10.1002/jcu.22756

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  96. Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy.

    Ishiguro T, Sugiyama Y, Ueda K, Muramatsu Y, Tsuda H, Kotani T, Michigami T, Tachikawa K, Akiyama T, Hayakawa M

    Brain & development   Vol. 41 ( 8 ) page: 721 - 725   2019.9

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    DOI: 10.1016/j.braindev.2019.03.015

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  97. Maternal protein S activity is associated with massive hemorrhage during caesarean section: retrospective case-control study.

    Imai K, Kotani T, Nakano T, Ushida T, Hirakawa A, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 32 ( 16 ) page: 2633 - 2637   2019.8

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    DOI: 10.1080/14767058.2018.1443067

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  98. Feasibility of using a handheld tissue hardness meter to quantify uterine contractions and its clinical application for obstetric bleeding management

    Imai Kenji, Kotani Tomomi, Ushida Takafumi, Moriyama Yoshinori, Nakano Tomoko, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 39 ( 6 ) page: 757 - 762   2019.8

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    DOI: 10.1080/01443615.2019.1581748

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  99. Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia.

    Iriyama T, Wang G, Yoshikawa M, Mimura N, Matsui H, Sayama S, Kumasawa K, Nagamatsu T, Koga K, Kotani T, Niimi K, Yamamoto E, Kellems RE, Xia Y, Osuga Y, Fujii T

    Scientific reports   Vol. 9 ( 1 ) page: 10107   2019.7

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    DOI: 10.1038/s41598-019-46660-4

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  100. Serological screening of immunoglobulin M and immunoglobulin G during pregnancy for predicting congenital cytomegalovirus infection

    Torii, Y; Yoshida, S; Yanase, Y; Mitsui, T; Horiba, K; Okumura, T; Takeuchi, S; Suzuki, T; Kawada, J; Kotani, T; Yamashita, M; Ito, Y

    BMC PREGNANCY AND CHILDBIRTH   Vol. 19 ( 1 ) page: 205   2019.6

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  101. Safety Evaluation of Tadalafil Treatment for Fetuses with Early-Onset Growth Restriction (TADAFER): Results from the Phase II Trial

    Maki, S; Tanaka, H; Tsuji, M; Furuhashi, F; Magawa, S; Kaneda, MK; Nii, M; Tanaka, K; Kondo, E; Tamaru, S; Ogura, T; Nishimura, Y; Endoh, M; Kimura, T; Kotani, T; Sekizawa, A; Ikeda, T

    JOURNAL OF CLINICAL MEDICINE   Vol. 8 ( 6 )   2019.6

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  102. Somatic symptom disorder manifested as acute abdominal pain during pregnancy preceding perinatal depression: a case report.

    Moriyama Y, Imai K, Nakano T, Kotani T, Kikkawa F

    Archives of women's mental health   Vol. 22 ( 2 ) page: 301 - 304   2019.4

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    DOI: 10.1007/s00737-018-0863-9

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  103. Relationship between cytokine profiles of cord blood and cord S100B levels in preterm infants

    Niwa, Y; Imai, K; Kotani, T; Miki, R; Nakano, T; Ushida, T; Moriyama, Y; Kikkawa, F

    EARLY HUMAN DEVELOPMENT   Vol. 129   page: 65 - 70   2019.2

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  104. Isolation of group B <i>Streptococcus</i> with reduced β-lactam susceptibility from pregnant women

    Moroi, H; Kimura, K; Kotani, T; Tsuda, H; Banno, H; Jin, W; Wachino, J; Yamada, K; Mitsui, T; Yamashita, M; Kikkawa, F; Arakawa, Y

    EMERGING MICROBES & INFECTIONS   Vol. 8 ( 1 ) page: 2 - 7   2019.1

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  105. The role of E2F8 in the human placenta

    Mizuno Masako, Miki Rika, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Niimi Kaoru, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Senga Takeshi, Iwase Akira, Kikkawa Fumitaka, Kotani Tomomi

    MOLECULAR MEDICINE REPORTS   Vol. 19 ( 1 ) page: 293 - 301   2019.1

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    DOI: 10.3892/mmr.2018.9617

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  106. Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders

    Matsukawa, S; Sumigama, S; Kotani, T; Wang, JW; Miki, R; Moriyama, Y; Nakano, T; Mano, Y; Tsuda, H; Tamakoshi, K; Kikkawa, F

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 84 ( 4 ) page: 396 - 406   2019

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  107. Clinical utility and limitations of FibCare (R) for the rapid measurement of fibrinogen concentrations: The first clinical experience

    Imai Kenji, Kotani Tomomi, Nakano Tomoko, Ushida Takafumi, Kikkawa Fumitaka

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   Vol. 57 ( 6 ) page: 899 - 900   2018.12

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    DOI: 10.1016/j.tjog.2018.10.024

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  108. A rare pseudo tumour in the extraembryonic coelom in first trimester of pregnancy: ultrasound and pathology.

    Sumigama S, Enomoto A, Matsukawa S, Ushida T, Imai K, Nakano T, Kotani T, Kikkawa F

    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     page: 1-2   2018.11

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    DOI: 10.1080/01443615.2018.1511971

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  109. Protective effects of mangafodipir against chemotherapy-induced ovarian damage in mice

    Qin, Y; Iwase, A; Murase, T; Bayasula; Ishida, C; Kato, N; Nakamura, T; Osuka, S; Takikawa, S; Goto, M; Kotani, T; Kikkawa, F

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 16 ( 1 ) page: 106   2018.10

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  110. TADAFER II: Tadalafil treatment for fetal growth restriction - a study protocol for a multicenter randomised controlled phase II trial

    Umekawa Takashi, Maki Shintaro, Kubo Michiko, Tanaka Hiroaki, Nii Masafumi, Tanaka Kayo, Osato Kazuhiro, Kamimoto Yuki, Tamaru Satoshi, Ogura Toru, Nishimura Yuki, Kodera Mayumi, Minamide Chisato, Nishikawa Masakatsu, Endoh Masayuki, Kimura Tadashi, Kotani Tomomi, Nakamura Masamitsu, Sekizawa Akihiko, Ikeda Tomoaki

    BMJ OPEN   Vol. 8 ( 10 ) page: e020948   2018.10

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    DOI: 10.1136/bmjopen-2017-020948

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  111. The rate of neonatal respiratory distress syndrome/transient tachypnea in the newborn and the amniotic lamellar body count in twin pregnancies compared with singleton pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 484   page: 293 - 297   2018.9

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    DOI: 10.1016/j.cca.2018.06.015

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  112. The impact of fertility treatment on the neonatal respiratory outcomes and amniotic lamellar body counts in twin pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Nakano Tomoko, Imai Kenji, Ushida Takafumi, Hirakawa Akihiro, Kinoshita Fumie, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 484   page: 192 - 196   2018.9

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    DOI: 10.1016/j.cca.2018.05.060

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  113. Thyroid Autoantibodies do not Impair the Ovarian Reserve in Euthyroid Infertile Women: A Cross-Sectional Study

    Osuka Satoko, Iwase Akira, Goto Maki, Takikawa Sachiko, Nakamura Tomoko, Murase Tomohiko, Kato Nao, Bayasula, Kotani Tomomi, Kikkawa Fumitaka

    HORMONE AND METABOLIC RESEARCH   Vol. 50 ( 7 ) page: 537 - 542   2018.7

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    DOI: 10.1055/a-0637-9430

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  114. Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model

    Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Ushida Takafumi, Iwase Akira, Nagai Taku, Toyokuni Shinya, Suzumura Akio, Kikkawa Fumitaka

    SCIENTIFIC REPORTS   Vol. 8 ( 1 ) page: 9221   2018.6

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    DOI: 10.1038/s41598-018-27626-4

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  115. Effect of molecular hydrogen on uterine inflammation during preterm labour

    Nakano Tomoko, Kotani Tomomi, Imai Kenji, Iitani Yukako, Ushida Takafumi, Tsuda Hiroyuki, Li Hua, Iwase Akira, Toyokuni Shinya, Kikkawa Fumitaka

    BIOMEDICAL REPORTS   Vol. 8 ( 5 ) page: 454 - 460   2018.5

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    DOI: 10.3892/br.2018.1082

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  116. Dengue fever during pregnancy.

    Tien Dat T, Kotani T, Yamamoto E, Shibata K, Moriyama Y, Tsuda H, Yamashita M, Kajiyama H, Duc Thien Minh D, Quang Thanh L, Kikkawa F

    Nagoya journal of medical science   Vol. 80 ( 2 ) page: 241 - 247   2018.5

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    DOI: 10.18999/nagims.80.2.241

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  117. Altered proteomic profile in umbilical arterial serum from mothers with schizophrenia.

    Moriyama Y, Kotani T, Ushida T, Imai K, Nakano T, Tsuda H, Kikkawa F

    Schizophrenia research     2018.3

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    DOI: 10.1016/j.schres.2018.02.024

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  118. Follicle dynamics: visualization and analysis of follicle growth and maturation using murine ovarian tissue culture.

    Murase T, Iwase A, Komatsu K, Bayasula, Nakamura T, Osuka S, Takikawa S, Goto M, Kotani T, Kikkawa F

    Journal of assisted reproduction and genetics   Vol. 35 ( 2 ) page: 339-343   2018.2

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    DOI: 10.1007/s10815-017-1073-5

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  119. The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis.

    Moroi H, Kotani T, Miki R, Tsuda H, Mizuno M, Ito Y, Ushida T, Imai K, Nakano T, Li H, Sumigama S, Yamamoto E, Iwase A, Kikkawa F

    Journal of clinical biochemistry and nutrition   Vol. 62 ( 1 ) page: 63 - 67   2018.1

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    DOI: 10.3164/jcbn.16-103

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  120. Simulation training is useful for shortening the decision-to-delivery interval in cases of emergent cesarean section.

    Iitani Y, Tsuda H, Ito Y, Moriyama Y, Nakano T, Imai K, Kotani T, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 31 ( 23 ) page: 3128 - 3132   2018

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    DOI: 10.1080/14767058.2017.1365126

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  121. Association of serum asymmetric dimethylarginine, homocysteine, and L-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy

    Maruta Ei, Wang Jingwen, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Imai Kenji, Sumigama Seiji, Niwa Yoshimitsu, Mitsui Takashi, Yoshida Shigeru, Yamashita Mamoru, Nawa Akihiro, Tamakoshi Koji, Kajiyama Hiroaki, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 475   page: 70 - 77   2017.12

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    DOI: 10.1016/j.cca.2017.10.007

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  122. Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114)

    Hirako Shima, Tsuda Hiroyuki, Ito Fumiya, Okazaki Yasumasa, Hirayama Tasuku, Nagasawa Hideko, Nakano Tomoko, Imai Kenji, Kotani Tomomi, Kikkawa Fumitaka, Toyokuni Shinya

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 61 ( 3 ) page: 176 - 182   2017.11

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    DOI: 10.3164/jcbn.17-17

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  123. Establishment and characterization of cell lines derived from complete hydatidiform mole

    Yamamoto Eiko, Niimi Kaoru, Kiyono Tohru, Yamamoto Toshimichi, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   Vol. 40 ( 3 ) page: 614 - 622   2017.9

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    DOI: 10.3892/ijmm.2017.3067

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  124. ABERRANT MATERNAL INFLAMMATION IN PREGNANCY LEADS TO PERSISTENCE OF RISK FACTORS FOR CARDIOVASCULAR DISEASE IN THE OFFSPRING

    Ushida Takafumi, Macdonald-Goodfellow Shannyn, Tse M. Yat, Winn Louise, Pang Stephen, Adams Michael, Kotani Tomomi, Kikkawa Fumitaka, Graham Charles

    PLACENTA   Vol. 57   page: 243 - 243   2017.9

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    DOI: 10.1016/j.placenta.2017.07.074

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  125. PERSISTENCE OF RISK FACTORS ASSOCIATED WITH MATERNAL CARDIOVASCULAR DISEASE FOLLOWING ABERRANT INFLAMMATION IN RAT PREGNANCY

    Ushida, T; Macdonald-Goodfellow, S; Quadri, A; Tse, MY; Winn, L; Pang, S; Adams, M; Kotani, T; Kikkawa, F; Graham, C

    PLACENTA   Vol. 57   page: 279 - 279   2017.9

  126. Persistence of risk factors associated with maternal cardiovascular disease following aberrant inflammation in rat pregnancy

    Ushida Takafumi, Macdonald-Goodfellow Shannyn K., Quadri Allegra, Tse M. Yat, Winn Louise M., Pang Stephen C., Adams Michael A., Kotani Tomomi, Kikkawa Fumitaka, Graham Charles H.

    BIOLOGY OF REPRODUCTION   Vol. 97 ( 1 ) page: 143 - 152   2017.7

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    DOI: 10.1093/biolre/iox072

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  127. c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling. Reviewed

    Sekiya Y, Yamamoto E, Niimi K, Nishino K, Nakamura K, Kotani T, Kajiyama H, Shibata K, Kikkawa F

    Oncology   Vol. 92 ( 5 )   2017.3

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    DOI: 10.1159/000458529

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  128. A Novel Approach to Detecting Postpartum Hemorrhage Using Contrast-Enhanced Ultrasound. Reviewed

    Imai K, Kotani T, Tsuda H, Nakano T, Hirakawa A, Kikkawa F

    Ultrasound in medicine & biology   Vol. 43 ( 3 ) page: 615-620   2017.3

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    DOI: 10.1016/j.ultrasmedbio.2016.11.008

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  129. Observed-to-expected MRI fetal lung volume can predict long-term lung morbidity in infants with congenital diaphragmatic hernia. Reviewed

    Tsuda H, Kotani T, Miura M, Ito Y, Hirako S, Nakano T, Imai K, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 30 ( 13 ) page: 1509 - 1513   2017

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    DOI: 10.1080/14767058.2017.1299126

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  130. A large mediastinal tumour invading into the liver with foetal hydrops: A rare case of infantile myofibromatosis

    Ushida Takafumi, Tsuda Hiroyuki, Takahara Taishi, Takahashi Yuichiro, Kotani Tomomi, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 37 ( 6 ) page: 821 - 823   2017

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    DOI: 10.1080/01443615.2017.1303468

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  131. Kisspeptin in the hypothalamus of two rat models of polycystic ovary syndrome. Reviewed

    Osuka S, Iwase A, Nakahara T, Kondo M, Saito A, Bayasula, Nakamura T, Takikawa S, Goto M, Kotani T, Kikkawa F

    Endocrinology     page: en20161333   2016.12

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    DOI: 10.1210/en.2016-1333

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  132. Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model Reviewed

    Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y3, Wang J4, Miki R4, Yamamoto E5, Iwase A1, Bando YK6, Hirayama M7, Ohno K7, Toyokuni S8, Kikkawa F1.

    Free Radic Biol Med   Vol. 101   page: 524-533   2016.12

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    DOI: 0.1016/j.freeradbiomed.2016.10.491.

  133. Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. Reviewed

    Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y, Wang J, Miki R, Yamamoto E, Iwase A, Bando YK, Hirayama M, Ohno K, Toyokuni S, Kikkawa F

    Free radical biology & medicine   Vol. 101   page: 524-533   2016.12

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    DOI: 10.1016/j.freeradbiomed.2016.10.491

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  134. Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single-institution experience. Reviewed

    Tamauchi S, Kajiyama H, Sakata J, Sekiya R, Suzuki S, Mizuno M, Utsumi F, Niimi K, Kotani T, Shibata K, Kikkawa F

    The journal of obstetrics and gynaecology research   Vol. 42 ( 12 ) page: 1796-1801   2016.12

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    DOI: 10.1111/jog.13100

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  135. Lipocalin 2 as a new biomarker for fetal lung hypoplasia in congenital diaphragmatic hernia. Reviewed

    Tsuda H, Kotani T, Nakano T, Imai K, Hirako S, Li H, Kikkawa F

    Clinica chimica acta; international journal of clinical chemistry   Vol. 462   page: 71-76   2016.11

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    DOI: 10.1016/j.cca.2016.08.023

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  136. Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia. Reviewed

    Hirako S, Tsuda H, Kotani T, Sumigama S, Mano Y, Nakano T, Imai K, Li H, Toyokuni S, Kikkawa F

    Phytotherapy research : PTR   Vol. 30 ( 9 ) page: 1474-80   2016.9

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    DOI: 10.1002/ptr.5645

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  137. Serum pentraxin 3 as a possible marker for mature cystic teratomas. Reviewed

    Ishida C, Iwase A, Osuka S, Goto M, Takikawa S, Nakamura T, Kotani T, Kikkawa F

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology   Vol. 32 ( 9 ) page: 733-736   2016.9

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    DOI: 10.3109/09513590.2016.1157862

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  138. Increase of kisspeptin-positive cells in the hypothalamus of a rat model of polycystic ovary syndrome. Reviewed

    Kondo M, Osuka S, Iwase A, Nakahara T, Saito A, Bayasula, Nakamura T, Goto M, Kotani T, Kikkawa F

    Metabolic brain disease   Vol. 31 ( 3 ) page: 673-81   2016.6

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    DOI: 10.1007/s11011-016-9807-0

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  139. Severe Hemoperitoneum During Pregnancy with Obstructed Hemivagina and Ipsilateral Renal Anomaly Syndrome: A Case Report. Reviewed

    Muraoka A, Tsuda H, Kotani T, Kikkawa F

    The Journal of reproductive medicine   Vol. 61 ( 5-6 ) page: 290-4   2016.5

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  140. Pain-reducing anesthesia prevents oxidative stress in human term placenta. Reviewed

    Tsuzuki Y, Yamashita Y, Hattori Y, Hua Li G, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S, Nishiwaki K, Toyokuni S

    Journal of clinical biochemistry and nutrition   Vol. 58 ( 2 ) page: 156-60   2016.3

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    DOI: 10.3164/jcbn.15-138

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  141. Efficacy and safety of daikenchuto (TJ-100) in pregnant women with constipation. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Hayakawa H, Kikkawa F

    Taiwanese journal of obstetrics & gynecology   Vol. 55 ( 1 ) page: 26-9   2016.2

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    DOI: 10.1016/j.tjog.2015.12.003

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  142. Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia. Reviewed

    Imai K, Kotani T, Tsuda H, Mano Y, Nakano T, Ushida T, Li H, Miki R, Sumigama S, Iwase A, Hirakawa A, Ohno K, Toyokuni S, Takeuchi H, Mizuno T, Suzumura A, Kikkawa F

    Free radical biology & medicine   Vol. 91   page: 154-63   2016.2

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    DOI: 10.1016/j.freeradbiomed.2015.12.015

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  143. Relationship between the cortisol levels in umbilical cord blood and neonatal RDS/TTN in twin pregnancies. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Nakano T, Hua L, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 29 ( 13 ) page: 2151-6   2016

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    DOI: 10.3109/14767058.2015.1077510

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  144. Risk assessment for neonatal RDS/TTN using gestational age and the amniotic lamellar body count in twin pregnancies. Reviewed

    Tsuda H, Hirakawa A, Kotani T, Sumigama S, Mano Y, Nakano T, Imai K, Kawabata I, Takahashi Y, Iwagaki S, Kikkawa F

    Clinica chimica acta; international journal of clinical chemistry   Vol. 451 ( Pt B ) page: 301-4   2015.12

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    DOI: 10.1016/j.cca.2015.10.013

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  145. Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury. Reviewed

    Nakano T, Kotani T, Mano Y, Tsuda H, Imai K, Ushida T, Li H, Miki R, Sumigama S, Sato Y, Iwase A, Hirakawa A, Asai M, Toyokuni S, Kikkawa F

    Journal of clinical biochemistry and nutrition   Vol. 57 ( 3 ) page: 178-82   2015.11

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    DOI: 10.3164/jcbn.15-90

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  146. Is the serum l-arginine level during early pregnancy a predictor of pregnancy-induced hypertension? Reviewed

    Wang J, Kotani T, Tsuda H, Mano Y, Sumigama S, Li H, Komatsu K, Miki R, Maruta E, Niwa Y, Mitsui T, Yoshida S, Yamashita M, Tamakoshi K, Kikkawa F

    Journal of clinical biochemistry and nutrition   Vol. 57 ( 1 ) page: 74-81   2015.7

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    DOI: 10.3164/jcbn.14-104

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  147. Impact of warning bleeding on the cortisol level in the fetus and neonatal RDS/TTN in cases of placenta previa. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Hua L, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 28 ( 9 ) page: 1057-60   2015.6

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    DOI: 10.3109/14767058.2014.942632

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  148. Viral load in children with congenital cytomegalovirus infection identified on newborn hearing screening. Reviewed

    Kawada J, Torii Y, Kawano Y, Suzuki M, Kamiya Y, Kotani T, Kikkawa F, Kimura H, Ito Y

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology   Vol. 65   page: 41-5   2015.4

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    DOI: 10.1016/j.jcv.2015.01.015

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  149. CYP51A1 induced by growth differentiation factor 9 and follicle-stimulating hormone in granulosa cells is a possible predictor for unfertilization. Reviewed

    Nakamura T, Iwase A, Bayasula B, Nagatomo Y, Kondo M, Nakahara T, Takikawa S, Goto M, Kotani T, Kiyono T, Kikkawa F

    Reproductive sciences (Thousand Oaks, Calif.)   Vol. 22 ( 3 ) page: 377-84   2015.3

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    DOI: 10.1177/1933719114529375

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  150. Amniotic lamellar body count: predicting and distinguishing neonatal respiratory complications in twin pregnancies. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Kawabata I, Takahashi Y, Iwagaki S, Hirakawa A, Kikkawa F

    Clinica chimica acta; international journal of clinical chemistry   Vol. 441   page: 75-8   2015.2

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    DOI: 10.1016/j.cca.2014.12.019

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  151. Catalytic ferrous iron in amniotic fluid as a predictive marker of human maternal-fetal disorders. Reviewed

    Hattori Y, Mukaide T, Jiang L, Kotani T, Tsuda H, Mano Y, Sumigama S, Hirayama T, Nagasawa H, Kikkawa F, Toyokuni S

    Journal of clinical biochemistry and nutrition   Vol. 56 ( 1 ) page: 57-63   2015.1

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    DOI: 10.3164/jcbn.14-82

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  152. Administration of umbilical cord blood cells transiently decreased hypoxic-ischemic brain injury in neonatal rats. Reviewed

    Hattori T, Sato Y, Kondo T, Ichinohashi Y, Sugiyama Y, Yamamoto M, Kotani T, Hirata H, Hirakawa A, Suzuki S, Tsuji M, Ikeda T, Nakanishi K, Kojima S, Blomgren K, Hayakawa M

    Developmental neuroscience   Vol. 37 ( 2 ) page: 95-104   2015

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    DOI: 10.1159/000368396

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  153. Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition. Reviewed

    Minakami H, Maeda T, Fujii T, Hamada H, Iitsuka Y, Itakura A, Itoh H, Iwashita M, Kanagawa T, Kanai M, Kasuga Y, Kawabata M, Kobayashi K, Kotani T, Kudo Y, Makino Y, Matsubara S, Matsuda H, Miura K, Murakoshi T, Murotsuki J, Ohkuchi A, Ohno Y, Ohshiba Y, Satoh S, Sekizawa A, Sugiura M, Suzuki S, Takahashi T, Tsukahara Y, Unno N, Yoshikawa H

    The journal of obstetrics and gynaecology research   Vol. 40 ( 6 ) page: 1469-99   2014.6

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    DOI: 10.1111/jog.12419

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  154. Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Reviewed

    Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, Ohno K, Kikkawa F, Toyokuni S

    Free radical biology & medicine   Vol. 69   page: 324-30   2014.4

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    DOI: 10.1016/j.freeradbiomed.2014.01.037

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  155. Effect of placenta previa on neonatal respiratory disorders and amniotic lamellar body counts at 36-38weeks of gestation. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Hua L, Hayakawa H, Hayakawa M, Sato Y, Kikkawa F

    Early human development   Vol. 90 ( 1 ) page: 51-4   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.earlhumdev.2013.10.005

    PubMed

  156. Possible involvement of CD10 in the development of endometriosis due to its inhibitory effects on CD44-dependent cell adhesion. Reviewed

    Iwase A, Kotani T, Goto M, Kobayashi H, Takikawa S, Nakahara T, Nakamura T, Kondo M, Bayasula, Nagatomo Y, Kikkawa F

    Reproductive sciences (Thousand Oaks, Calif.)   Vol. 21 ( 1 ) page: 82-8   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1933719113488449

    PubMed

  157. Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor.

    Kotani T, Iwase A, Tsuda H, Mano Y, Yamamoto E, Nakano T, Hasegawa Y, Li H, Sumigama S, Itakura A, Kikkawa F

    Biol Reprod   Vol. 89 ( 3 )   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1095/biolreprod.

  158. A proteomic analysis of human follicular fluid: comparison between fertilized oocytes and non-fertilized oocytes in the same patient. Reviewed

    Bayasula, Iwase A, Kobayashi H, Goto M, Nakahara T, Nakamura T, Kondo M, Nagatomo Y, Kotani T, Kikkawa F

    Journal of assisted reproduction and genetics   Vol. 30 ( 9 ) page: 1231-8   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10815-013-0004-3

    PubMed

  159. Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. Reviewed

    Kotani T, Iwase A, Tsuda H, Mano Y, Yamamoto E, Nakano T, Hasegawa Y, Li H, Sumigama S, Itakura A, Kikkawa F

    Biology of reproduction   Vol. 89 ( 3 ) page: 52   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1095/biolreprod.113.108480

    PubMed

  160. The expression and characterization of endoglin in uterine leiomyosarcoma. Reviewed

    Mitsui H, Shibata K, Mano Y, Suzuki S, Umezu T, Mizuno M, Yamamoto E, Kajiyama H, Kotani T, Senga T, Kikkawa F

    Clinical & experimental metastasis   Vol. 30 ( 6 ) page: 731-40   2013.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10585-013-9574-9

    PubMed

  161. Amniotic lamellar body count and congenital diaphragmatic hernia in humans and in a rat model. Reviewed

    Watanabe Y, Tsuda H, Kotani T, Sumigama S, Mano Y, Hayakawa M, Sato Y, Kikkawa F

    Pediatric research   Vol. 73 ( 3 ) page: 344-8   2013.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/pr.2012.187

    PubMed

  162. Mucinous cystic neoplasm of the pancreas with severe dysplasia during pregnancy: case report and review of the literature. Reviewed

    Tsuda H, Kotani T, Sumigama S, Mano Y, Shimoyama Y, Kikkawa F

    Taiwanese journal of obstetrics & gynecology   Vol. 51 ( 4 ) page: 635-8   2012.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tjog.2012.09.022

    PubMed

  163. A case report of placental mesenchymal dysplasia with an increased VEGF-D expression.

    Kotani T, Sumigama S, Tsuda H, Mano Y, Yamamoto E, Iwase A, Shimoyama Y, Nagasaka T, Hayakawa H, Yamamoto T, Ino K, Kikkawa F.

    Placenta   Vol. 33 ( 10 ) page: 888-91   2012.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  164. Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway. Reviewed

    Nakahara T, Iwase A, Nakamura T, Kondo M, Bayasula, Kobayashi H, Takikawa S, Manabe S, Goto M, Kotani T, Kikkawa F

    Fertility and sterility   Vol. 98 ( 4 ) page: 1001-8.e1   2012.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.fertnstert.2012.06.008

    PubMed

  165. Validity of lamellar body count as a fetal lung maturity assessment in twin pregnancy. Reviewed

    Tsuda H, Kotani T, Sumigama S, Kawabata I, Takahashi Y, Iwagaki S, Kigoshi K, Kikkawa F

    Twin research and human genetics : the official journal of the International Society for Twin Studies   Vol. 15 ( 4 ) page: 547-9   2012.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1017/thg.2012.29

    PubMed

  166. Establishment of a human nonluteinized granulosa cell line that transitions from the gonadotropin-independent to the gonadotropin-dependent status. Reviewed

    Bayasula, Iwase A, Kiyono T, Takikawa S, Goto M, Nakamura T, Nagatomo Y, Nakahara T, Kotani T, Kobayashi H, Kondo M, Manabe S, Kikkawa F

    Endocrinology   Vol. 153 ( 6 ) page: 2851-60   2012.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2011-1810

    PubMed

  167. Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptides. Reviewed

      Vol. 7 ( 8 ) page: e43745   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0043745

    PubMed

  168. The loss of endoglin promotes the invasion of extravillous trophoblasts. Reviewed

    Mano Y, Kotani T, Shibata K, Matsumura H, Tsuda H, Sumigama S, Yamamoto E, Iwase A, Senga T, Kikkawa F

    Endocrinology   Vol. 152 ( 11 ) page: 4386-94   2011.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2011-1088

    PubMed

  169. Maternal mental disorders and pregnancy outcomes: a clinical study in a Japanese population. Reviewed

    Hironaka M, Kotani T, Sumigama S, Tsuda H, Mano Y, Hayakawa H, Tanaka S, Ozaki N, Tamakoshi K, Kikkawa F

    The journal of obstetrics and gynaecology research   Vol. 37 ( 10 ) page: 1283-9   2011.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1447-0756.2010.01512.x

    PubMed

  170. Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment. Reviewed

    Iwase A, Goto M, Manabe S, Hirokawa W, Kobayashi H, Nakahara T, Takikawa S, Kotani T, Sumigama S, Tsuda H, Nakayama T, Suzuki N, Matsushita T, Kikkawa F

    Fertility and sterility   Vol. 95 ( 6 ) page: 2124.e5-7   2011.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.fertnstert.2011.01.011

    PubMed

  171. Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN). Reviewed

    Tsuda H, Takahashi Y, Iwagaki S, Uchida Y, Kawabata I, Hayakawa M, Sumigama S, Hayakawa H, Kotani T, Kikkawa F

    Journal of perinatal medicine   Vol. 39 ( 3 ) page: 245-50   2011.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1515/JPM.2011.006

    PubMed

  172. Intra-amniotic infection increases amniotic lamellar body count before 34 weeks of gestation. Reviewed

    Tsuda H, Takahashi Y, Iwagaki S, Kawabata I, Hayakawa H, Kotani T, Shibata K, Kikkawa F

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians   Vol. 23 ( 10 ) page: 1230-6   2010.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/14767051003615442

    PubMed

  173. Elevated levels of aldosterone in the amniotic fluid was observed in two cases of congenital mesoblastic nephroma. Reviewed

    Kotani T, Sumigama S, Hayakawa H, Mano Y, Tsuda H, Sugiyama C, Kawachi F, Hironaka M, Kato T, Kaneko K, Hayakawa M, Kikkawa F.

    Ultrasound Obstet Gynecol.   Vol. 36 ( 2 ) page: 256-8   2010.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  174. Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells. Reviewed

    Morimitsu A, Sumigama S, Kotani T, Mano Y, Suzuki K, Araki-Taguchi M, Yamamoto E, Hayakawa H, Okada M, Itakura A, Kikkawa F

    Gynecologic and obstetric investigation   Vol. 69 ( 1 ) page: 67-72   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000257663

    PubMed

  175. *Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line Reviewed

    Kotani T, Iwase A, Ino K, Sumigama S, Yamamoto E, Hayakawa H, Nagasaka T, Itakura A, Nomura S, Kikkawa F

    Endocrinology   Vol. 150 ( 9 ) page: 4376-4385   2009.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    The reduced migration/invasion of extravillous trophoblasts (EVTs) is a key feature of the genesis of preeclampsia. We and others previously reported that transcriptional factors activator protein-2 (AP-2) alpha and AP-2gamma act as suppressors of tumor invasion. The present study examined the expressions of AP-2alpha and AP-2gamma in preeclamptic placenta vs. control placenta and investigated their effect on the function of EVTs. The expressions of AP-2alpha and AP-2gamma were elevated in the preeclamptic placentas in comparison with the gestational age-matched control placentas. Their expressions also increased in EVTs of the preeclamptic placentas. Thereafter, we transfected AP-2alpha or AP-2gamma into human EVT cell line, HTR-8/SVneo. The overexpression of AP-2alpha or AP-2gamma decreased the migratory and invasive abilities in HTR-8/SVneo cells. This was followed by the reduction of protease activated receptor-1 and matrix metalloproteinases and a significant induction of plasminogen activator inhibitor-1 and the tissue inhibitor of metalloproteinase-1. AP-2alpha and AP-2gamma were weakly expressed in the cultured EVTs and HTR-8/SVneo cells, whereas they were induced by TNF-alpha, which increases in preeclamptic placenta and impairs trophoblast invasion. In the presence of TNF-alpha, the invasion of the HTR-8/SVneo cells was partially restored by a blocking of AP-2 induction using small interfering RNA of AP-2. The present data suggest that AP-2 may suppress trophoblast migration and invasion, thus leading to a shallow placentation in preeclampsia.

  176. Placenta previa increta/percreta in Japan: a retrospective study of ultrasound findings, management and clinical course. Reviewed

    Sumigama S, Itakura A, Ota T, Okada M, Kotani T, Hayakawa H, Yoshida K, Ishikawa K, Hayashi K, Kurauchi O, Yamada S, Nakamura H, Matsusawa K, Sakakibara K, Ito M, Kawai M, Kikkawa F

    The journal of obstetrics and gynaecology research   Vol. 33 ( 5 ) page: 606-11   2007.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1447-0756.2007.00619.x

    PubMed

  177. Placental leucine aminopeptidase might regulate the effects of oxytocin with resolution in endothelial cells. Reviewed

    Sano M, Itakura A, Ito M, Takeuchi M, Okada M, Kotani T, Mizutani S, Kikkawa F

    Medical science monitor : international medical journal of experimental and clinical research   Vol. 11 ( 7 ) page: BR195-9   2005.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    PubMed

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Books 21

  1. 【鑑別フローチャートで症候ごとに考える 妊娠期別 産科救急ナビゲーション】(第2部)疾患編 (CHAPTER 22)リステリア感染症(解説)

    夫馬和也 小谷友美( Role: Joint author)

    ペリネイタルケア  2025.1 

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    Language:Japanese

  2. 【鑑別フローチャートで症候ごとに考える 妊娠期別 産科救急ナビゲーション】(第2部)疾患編 (CHAPTER 22)リステリア感染症(解説)

    田野翔 小谷友美

    2025.1 

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    Language:Japanese

  3. 【周産期の画像診断[第3版]】母体・胎児編 CT・MRI診断 A.母体 頭蓋内病変(解説)

    小谷友美 今井健史( Role: Joint author)

    2024.12 

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    Responsible for pages:255-258   Language:Japanese

    DOI: 10.24479/peri.0000001854

  4. 【周産期(産科)の手術の工夫-筆者はこうしている】帝王切開術 筋層縫合法:1層縫合と2層縫合(解説)

    小谷友美 牛田貴文 今井健史( Role: Joint author)

    2024.8 

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    Language:Japanese

  5. 【多職種で支える周産期リエゾン-プレコンセプションケアから虐待予防まで-】精神疾患を伴う妊産婦の支援 名古屋大学における実践でみえてきた課題(解説)

    立花昌子 後藤 紋香 小谷 友美

    2024.5 

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    Language:Japanese

  6. 【産婦人科医のための緊急対応サバイバルブック】産科編 周産期救急疾患への初期対応 常位胎盤早期剥離(解説)

    田野翔 小谷友美( Role: Joint author)

    臨床婦人科産科  2024.4 

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    Language:Japanese

  7. 【これでマスター! 最新 産婦人科ホルモン療法】(第2章)C 周産期 胎児肺成熟の促進(解説)

    夫馬和也 小谷友美( Role: Joint author)

    産科と婦人科  2024.3 

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    Language:Japanese

  8. コンセンサスに基づく新たな体重管理の構築(解説)

    田野翔 小谷友美( Role: Joint author)

    糖尿病と妊娠  2024.2 

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    Language:Japanese

  9. 【周産期の画像診断[第3版]】母体・胎児編 CT・MRI診断 A.母体 癒着胎盤(解説)

    松尾聖子、小谷友美( Role: Joint author)

    2024.1 

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    Language:Japanese

    DOI: 10.24479/peri.0000001856

  10. 精神疾患合併妊娠

    ( Role: Contributor)

    2023.12  ( ISBN:978-4-8404-8442-8

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    Total pages:416   Language:Japanese Book type:Textbook, survey, introduction

  11. 【各種診療ガイドラインにみる挙児希望女性の合併症・併存疾患の取り扱い-プレコンセプションから妊娠・出産まで-】精神疾患 International journal

    佐藤 昌司, 小谷 友美( Role: Joint author)

    産婦人科の実際  2023.4 

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    Responsible for pages:393-399   Language:Japanese Book type:Scholarly book

    DOI: 10.18888/sp.0000002523

  12. 今日の治療指針私はこう治療している2023

    ( Role: Contributor)

    2023.1 

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    Language:Japanese

  13. 治療法の再整理とアップデートのために 専門家による私の治療 産褥乳腺炎(解説)

    小谷友美( Role: Sole author)

    日本医事新報  2022.12 

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    Responsible for pages:50   Language:Japanese

  14. 【帝王切開分娩のすべて-この1冊でわかるNew Normal Standard】術式の工夫 子宮筋層縫合術の工夫 縫合不全・瘢痕部菲薄化の予防のために(解説)

    小谷友美 牛田貴文( Role: Joint author)

    2022.12 

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    Responsible for pages:1196-1201   Language:Japanese

    DOI: 10.11477/mf.1409210835

  15. 【産婦人科における素朴な疑問と解説(2)産科編】Rh式血液型不適合妊娠よりずっと頻度が高いABO式血液型不適合妊娠でトラブルが少ないのはなぜ?(解説)

    田野翔 小谷友美( Role: Joint author)

    産科と婦人科  2022.11 

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    Responsible for pages:1201-1205   Language:Japanese

  16. 【生殖医療の安全性-どんなリスクと留意点があるのか?】受精卵,児・家族への影響 先天性心疾患と循環器系異常(解説)

    森本 美仁, 小谷 友美, 加藤 太一

    臨床婦人科産科  2022.11 

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    Responsible for pages:1123-1128   Language:Japanese

  17. 【見て、聞いて、触って、身体所見から考える妊産褥婦の異常とその対応】帯下が多い、臭う(解説)

    松尾聖子 小谷友美( Role: Joint author)

    周産期医学   2022.8 

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    Responsible for pages:1145-1147   Language:Japanese

  18. 【子宮内膜症の最新知識-この1冊で重要ポイントを網羅する】周産期予後 子宮内膜症・子宮腺筋症女性における周産期合併症リスクの考察(解説)

    小谷友美 牛田貴文( Role: Joint author)

    2022.7 

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    Responsible for pages:670-675   Language:Japanese

    DOI: 10.11477/mf.1409210741

  19. 今日の治療指針私はこう治療している2022

    小谷友美( Role: Contributor ,  妊娠悪阻)

    医学書院  2022.1 

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    Responsible for pages:1381-1382  

  20. 胎児超音波診断を活かす-産科医と新生児科医からの情報提供-

    小谷友美、伊藤美春(胸腔内疾患 先天性横隔膜ヘルニア)

    周産期医学  2021.9 

  21. 【周産期の周辺を強化する-プレコンセプションケアと産後ケアの充実に向けて】

    小谷友美.(他科と連携したプレコンセプションケアと産後ケア 精神科医/心療内科医・公認心理師との連携 産婦人科から.)

    周産期医学  2021.4 

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Presentations 10

  1. 産科ハイリスクの最前線 合併症回避の戦略と実践  Invited

    小谷友美

    中日本婦人科手術手技セミナー 

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    Event date: 2025.2

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  2. 切れ目ない支援インターコンセプションケア Invited

    小谷友美

    西三河周産期医療ネットワーク協議会  2024.11.16 

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    Event date: 2024.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  3. 子宮内膜症と産後うつとの関係について

    小谷友美

    第69回日本生殖医学会学術講演会 

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    Event date: 2024.11

    Presentation type:Poster presentation  

  4. DEI推進委員会調査報告3- Diversity Equity and Inclusion(DEI)推進に向けた 会員意識調査から見えてきたこと

    小谷友美

    第60回日本周産期・新生児医学会学術集会 

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    Event date: 2024.7

    Language:Japanese   Presentation type:Poster presentation  

  5. 生殖補助医療と非前置癒着胎盤 Invited

    小谷友美

    第34回日本産婦人科・新生児血液学会学術集会  2024.6.8 

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    Event date: 2024.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  6. 胎児期の環境がこころの発達に及ぼす影響 Invited

    小谷友美

    超早産児神経発達症研究会 2023年度セミナー 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  7. 学会の取り組み 精神疾患を合併した、或いは合併の可能性のある妊産婦の診療ガイドの活用法 Invited

    小谷友美

    母と子のメンタルヘルス研修会(入門編)  2023.6.3 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  8. 妊産婦の不安によりそう NIPTの運用  Invited

    小谷友美

    愛知県周産期協議会専門相談研修会  2023.3.9 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  9. 胎児期の管理 胎内炎症が神経発達に及ぼす影響 Invited

    小谷友美

    第1回超早産児神経発達症研究会セミナー   2022.9.25 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  10. メンタル不調の妊産婦さんへの支援を考える Invited

    小谷友美

    愛知県産婦人科医会 MCMC母と子のメンタルヘルス研修会(入門編)  2022.7.2 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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Research Project for Joint Research, Competitive Funding, etc. 2

  1. 妊娠高血圧症候群の成因へのエンドグリンの関与の解明

    2011.4 - 2012.3

    神澤医学研究振興財団第15回研究助成金 

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    Grant type:Competitive

    妊娠高血圧症候群は、未だに母児ともに予後不良な疾患である。児は子宮内胎児発育遅延を合併し、新生児医
    療の進歩によりその生存率は改善したものの、脳障害などの後遺障害が問題となる。他方、母体では、HELLP
    症候群や脳血管障害といった重篤な合併症が問題となっている。脳血管障害は、我が国の妊産婦死亡原因の約
    25%を占めることが明らかとなり、その管理に関心が高まっている。病態は絨毛外絨毛細胞(EVT)の母体脱落
    膜への浸潤不全による胎盤低形成にあるとされるものの、未だ不明な点が多いために、有効な予防法や治療法
    が確立されていない。我々は、癌研究領域でのendoglinが細胞浸潤へ関与するという報告およびに妊娠高血圧
    症候群胎盤ではendoglin発現が増加するという報告に着目し、endoglinが胎盤低形成に関与しているという
    仮説をたてた。Endoglinが低酸素やTGF-といった胎盤低形成因子によって発現増加するという報告や、ラッ
    ト動物実験でその注入によりHELLP症候群モデルを作成したという報告もあり、本研究では、成因を解明する
    と同時に、重篤な合併症の発症予測・予防法を確立し、妊娠高血圧症候群の予後の向上を目指したい。

  2. 胎盤プロテアーゼとその転写因子AP-2からみた妊娠中毒症の病態解明と治療法の展開

    2002.4 - 2004.12

    財団法人 日母おぎゃー献金基金 

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    Grant type:Competitive

    転写因子が妊娠高血圧症候群の病態に関与しており、よりその機構を明らかにすることにより、妊娠高血圧症候群の発症予防にも応用できる可能性が示唆された

KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. Interdisciplinary research toward the feto-maternal interface environmental strategies with targeted proteomics

    Grant number:23KK0157  2023.9 - 2027.3

    Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (International Collaborative Research)

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    Authorship:Principal investigator 

    Grant amount:\21060000 ( Direct Cost: \16200000 、 Indirect Cost:\4860000 )

  2. 早産児の神経学的予後向上に向けた病態解明~腸脳相関に着目して~

    Grant number:22K09638  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    小谷 友美

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    近年、女性が多様な生き方を選択・実現できる社会へと変容し、晩産化や生殖補助医療による妊娠が増加している。さらに、食行動も変化している。これらの生活様式の変化は、妊娠高血圧腎症や早産など周産期合併症の発症リスクと関連する。本研究では、効率的な戦略として、妊娠前からの予防戦略を開発する。動物モデルや臨床検体を用いた解析を実施し、母体腸内細菌叢および関連する食行動などを統合的に理解する知見を確立し、最終的には、児の神経学的後遺症発症を防止する妊娠前からの介入法の開発を目指す。
    新生仔マウス脳より回収した初代培養ミクログリアを用いて、IL-17A刺激によるmiRNAの発現変化の網羅的解析から、mmu-miRNA-206-3pの発現増加を明らかにした。mmu-miRNA-206-3pの発現増加により標的遺伝子であるIgf-1, Hdac4の発現低下を確認した。これらの変化は自閉症スペクトラムや胎内で炎症環境に曝露神経に起因する神経発達症モデル(maternal immune activation;MIA)での変化に類似していた。mmu-miRNA-206-3pはhsa-miRNA-206-3pとも相同性があり、共通する標的遺伝子を有しており、今後の臨床応用につながる結果と考えられ、論文発表にいたった。また、MIA仮説についての総説を作成し、国際書籍に掲載予定となっている。リポポリ多糖誘導によるMIA動物モデルにおいてCD11cミクログリア分画の発達期の一過性増加が弱いという結果を得た。発達期に一過性増加を示すことは、in silico解析でマウス、ヒトでも確認できたが、寿命の相違から、時期はヒトのほうが遅くなっていた。また、ASDの剖検脳のin scilico解析では、ASDで少ないことが示された。また前述の論文のように、絨毛膜羊膜炎母体の臍帯血で、コントールと比べ、IL-17Aの増加、IGF-1の低下を示した。髄鞘化所見とCD11cミクログリアとの関連を解析した。現在、異常腸内細菌叢モデルとして、抗生剤投与モデルでの早産率が高くなることが判明したが、早産仔の生存率が低いため、異常腸内細菌叢モデルとして既報告のある、高脂肪食モデルを作成した。仔の行動実験で異常所見を認めており、現在解析を進めている。
    MIAの病態機序のひとつとしてIL-17A/miR-216-3pの可能性を明らかにして論文発表に至った。またMIAの病態機序について総説を作成した。MIA病態機序についてミクログリアの表面マーカーCD11cに着目した研究を論文投稿まですすめることができた。
    ヒトと動物モデルとのトランスレーションを目指している。高脂肪食負荷期間を短縮して妊娠率向上に努めた。今後は肥満妊婦からの臍帯血などの検討も実施予定である。

  3. Elucidation of pathogenesis and establishment of early diagnosis of autoimmune-related reproductive dysfunction by focusing on novel autoantibody-target antigens

    Grant number:20H03819  2020.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Akira Iwase

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    Authorship:Coinvestigator(s) 

    We found autoantibodies that react with ovarian granulosa cells in the serum of thyroid autoantibody-positive ovarian insufficiency patients and identified their target protein, POTEF.
    We demonstrated that POTEF is expressed in human ovarian granulosa cells and oocytes, and that its expression is altered by follicle development and suppresses cell proliferation. We established the basis for an anti-POTEF antibody assay system in human serum using purified POTEF protein and found that anti-POTEF antibody titers in sera from patients with ovarian insufficiency were significantly higher than those from women with normal ovarian function.
    We found a binding site for FOXL2, a transcription factor important for ovarian differentiation, in the promoter region of POTEF, and found a trend toward higher FOXL2 levels in women with PCOS, whose main symptom is ovulatory failure.

  4. Epigenetic change by perinatal inflammation and its regulation

    Grant number:17K11230  2017.4 - 2020.3

    KOTANI TOMOMI

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Preterm birth occurs by inflammation, and the fetus is affected by exposure to inflammation. In the present study, it was shown that exposure to inflammation in utero caused postnatal autism spectrum like findings, accompanied with several alterations in the brain tissues, amyglada, including microglial activation. Furthermore, some of the molecular mechanisms have been elucidated. In addition, as a preventive strategy against , the results suggesting that antenatal molecular hydrogen administration may prevent the development of postnatal neuropsychiatric disorders in preterm infants. Pregnant women with other inflammation related diseases will be also indicated as candidates for this preventive strategy, although further studies are needed.

  5. Interdisciplinary study of obstetric management and gynecological rare tumor in Vietnam

    Grant number:15H02660  2015.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    FUMITAKA KIKKAWA

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    Authorship:Coinvestigator(s) 

    For the purpose of not only the development of obstetrics and gynecology in Vietnam, but also creation of evidence worldwide and building of medical research resources to Japan, we investigated obstetric management and gynecological rare tumor in Vietnam at several facilities in Vietnam. In the present study, several findings, which are related to improvement of mothers and children's prognosis,were gained. First, Pregnancy with dengue fever causes thrombocytopenia, which is at risk of postpartum hemorrhage. Second, cesarean section scar pregnancy with an increase in cesarean section rate in Vietnam, could be managed by medication for only selected patients. Third, evaluation of cardiac function by ultrasound examination for fetal growth restriction would be beneficial. Lastly, we found that there was a high secondary rate after molar pregnancy in Vietnam and preventive measures might improve it.

  6. 早産児の後遺症発症の減少を目指して~分子状水素を用いた新規治療法の開発~

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

    小谷 友美

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    Authorship:Principal investigator 

  7. 妊娠高血圧症候群の病態機序へのスフィンゴシン1リン酸の関与の解明と治療への応用

    2008.4

    科学研究費補助金  基盤研究(C) 20599006

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    Authorship:Principal investigator 

    妊娠高血圧症候群の病態へのスフィンゴシン1リン酸(S1P)の関与を証明し、S1P受容体をターゲットとした新しい治療法を提示することを目的としている。現在では、妊娠高血圧症候群は絨毛外栄養膜細胞(extravillous trophoblast, EVT)の母体脱落膜への浸潤不全によって発症するという説が有力であり、本研究では、S1PのEVT浸潤機能に対する直接作用についてその分子機構まで解明する。また、S1Pの主な供給源は血球系であるとされているが、本研究では、脱落膜のスフィンゴシンキナーゼ(SK)により合成されたS1PがEVTをパラクラインに刺激しその浸潤を調節しているという仮説を証明する。S1PによるEVT浸潤調節の役割を証明した後、妊娠高血圧症候群症例におけるこれらの物質の発現を正常妊娠症例と比較検討する。さらに、新規免疫抑制薬FTY720をはじめとするS1P受容体作動薬の投与がEVT浸潤調節機構に及ぼす影響についてもその分子機構まで証明し、その治療的応用の可能性を提示していく。

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Teaching Experience (On-campus) 13

  1. 周産期ハイリスクケア論

    2024

  2. 先天性感染とメンタルヘルス

    2024

  3. 出生前診断

    2024

  4. 胎盤形成メカニズムとその異常

    2024

  5. 周産期ハイリスクケア論

    2023

  6. 出生前診断

    2023

  7. 先天性感染とメンタルヘルス

    2023

  8. 胎盤形成メカニズムとその異常

    2023

  9. 出生前診断

    2022

  10. 胎盤形成のメカニズムと異常

    2022

  11. 母子感染の予防と治療・周産期メンタルヘルス

    2022

  12. 胎盤形成のメカニズムと異常

    2020

  13. 母子感染の予防と治療・周産期メンタルヘルス

    2020

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