Faculty Profiles - UMEGAKI, Hiroyuki

Papers - UMEGAKI, Hiroyuki

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Effects of Weight-Bearing Resistance Training With Explosive Motions on the Rate of Force Development in Community-Dwelling Older Adults: A Randomized Controlled Trial

Kitada, T; Umegaki, H; Akima, H; Ishida, K; Nakatochi, M; Inoue, A; Huang, CH; Ando, M; Onishi, J; Kuzuya, M

JOURNAL OF PHYSICAL ACTIVITY & HEALTH page： 1 - 10 2025.3

Special Issue: Comprehensive geriatric assessment (CGA)-based healthcare guidelines 2024.

Umegaki H, Satake S, Ishii S, Kojima T, Akasaka H, Ogawa S, Ebihara S, Tsubata Y, Akishita M

Geriatrics & gerontology international Vol. 25 Suppl 1 page： 16 - 23 2025.3

Special Issue: Comprehensive geriatric assessment (CGA)-based healthcare guidelines 2024.

Shibasaki K, Ogawa S, Hosoi T, Ishii S, Mizukami K, Umegaki H, Mizokami F, Satake S, Akishita M

Geriatrics & gerontology international Vol. 25 Suppl 1 page： 9 - 15 2025.3

Validation of the Japanese version of the Clinical Frailty Scale

Komiya, H; Suzuki, Y; Watanabe, K; Nagae, M; Nakashima, H; Fujisawa, C; Miyahara, S; Tajima, T; Sakai, T; Takeya, Y; Kojima, T; Umeda-Kameyama, Y; Kawashima, S; Umegaki, H

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 25 ( 3 ) page： 411 - 417 2025.2

FI-lab in the emergency department and adverse outcomes among acutely hospitalized older adults

Nagae, M; Umegaki, H; Nakashima, H; Nishiuchi, T

ARCHIVES OF GERONTOLOGY AND GERIATRICS Vol. 129 page： 105649 2025.2

Machine Learning Prediction for Postdischarge Falls in Older Adults: A Multicenter Prospective Study

Takeshita, Y; Onishi, M; Masuda, H; Katsuhisa, M; Ikuta, K; Saizen, Y; Fujii, M; Kasamatsu, M; Inaizumi, N; Maeizumi, Y; Kishino, Y; Nakajima, T; Koujiya, E; Yamakawa, M; Takami, Y; Yamamoto, K; Umeda-Kameyama, Y; Satake, S; Umegaki, H; Takeya, Y

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION Vol. 26 ( 2 ) page： 105414 2025.2

Factors associated with decline in activities of daily living in home-based medical care

Nagae, M; Umegaki, H; Komiya, H; Watanabe, K; Yamada, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 87 ( 1 ) page： 173 - 177 2025.2

Dysphagia and quality of life in older adults receiving home-based medical care

Watanabe, K; Nagae, M; Miyahara, S; Umegaki, H

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 25 ( 2 ) page： 325 - 326 2025.1

FRAILTY IN INTERMEDIATE CARE FACILITIES THROUGH LIFE (LONG-TERM CARE INFORMATION SYSTEM FOR EVIDENCE) IN JAPAN

Sakai, T; Visvanathan, R; Jadczak, AD; Umegaki, H

INNOVATION IN AGING Vol. 8 page： 853 - 853 2024.12

Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl<sub>3</sub> model

Jin, XY; Yue, XL; Huang, Z; Meng, XK; Xu, SN; Wu, YN; Wan, Y; Inoue, A; Narisawa, M; Hu, LN; Shi, GP; Umegaki, H; Murohara, T; Lei, YN; Kuzuya, M; Cheng, XW

CELLULAR AND MOLECULAR LIFE SCIENCES Vol. 81 ( 1 ) page： 205 2024.12

Multidomain Intervention Trial for Preventing Cognitive Decline among Older Adults with Type 2 Diabetes: J-MIND-Diabetes

Sugimoto, T; Araki, A; Fujita, H; Fujita, K; Honda, K; Inagaki, N; Ishida, T; Kato, J; Kishi, M; Kishino, Y; Kobayashi, K; Kouyama, K; Kuroda, Y; Kuwahata, S; Matsumoto, N; Murakami, T; Noma, H; Ogino, J; Ogura, M; Ohishi, M; Shimada, H; Sugimoto, K; Takenaka, T; Tamura, Y; Tokuda, H; Uchida, K; Umegaki, H; Sakurai, T

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE Vol. 11 ( 6 ) page： 1604 - 1614 2024.12

Management of older adults with diabetes mellitus: Perspective from geriatric medicine

Umegaki, H

JOURNAL OF DIABETES INVESTIGATION Vol. 15 ( 10 ) page： 1347 - 1354 2024.10

Objective physical function declines in the absence of subjective physical complaints among patients with amnestic mild cognitive impairments and mild alzheimer's disease

Fujisawa, C; Umegaki, H; Sugimoto, T; Nakashima, H; Komiya, H; Watanabe, K; Nagae, M; Yamada, Y; Tajima, T; Sakai, T; Sakurai, T

EUROPEAN GERIATRIC MEDICINE Vol. 15 ( 5 ) page： 1503 - 1508 2024.10

Frailty Index Based on Common Laboratory Tests for Patients Starting Home-Based Medical Care

Nakashima, H; Watanabe, K; Komiya, H; Fujisawa, C; Yamada, Y; Sakai, T; Tajima, T; Umegaki, H

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION Vol. 25 ( 9 ) page： 105114 2024.9

Dual Sensory Impairment Predicts an Increased Risk of Postdischarge Falls in Older Patients

Yamada, Y; Nakashima, H; Nagae, M; Watanabe, K; Fujisawa, C; Komiya, H; Tajima, T; Sakai, T; Satake, S; Takeya, Y; Umeda-Kameyama, Y; Umegaki, H

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION Vol. 25 ( 9 ) page： 105123 2024.9

Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial

Sakurai, T; Sugimoto, T; Akatsu, H; Doi, T; Fujiwara, Y; Hirakawa, A; Kinoshita, F; Kuzuya, M; Lee, SY; Matsumoto, N; Matsuo, K; Michikawa, M; Nakamura, A; Ogawa, S; Otsuka, R; Sato, K; Shimada, H; Suzuki, H; Suzuki, H; Takechi, H; Takeda, S; Uchida, K; Umegaki, H; Wakayama, S; Arai, H

ALZHEIMERS & DEMENTIA Vol. 20 ( 6 ) page： 3918 - 3930 2024.6

Association of marital relationship with quality of life among older adults with mild cognitive impairment and mild dementia

Fujisawa, C; Nakashima, H; Komiya, H; Watanabe, K; Yamada, Y; Tajima, T; Umegaki, H

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 24 ( 6 ) page： 646 - 647 2024.6

Hospital-associated complications in frail older adults.

Umegaki H

Nagoya journal of medical science Vol. 86 ( 2 ) page： 181 - 188 2024.5

Association between intrinsic capacity and oral health in older patients in a frailty clinic

Miyahara, S; Maeda, K; Kawamura, K; Matsui, Y; Satake, S; Arai, H; Umegaki, H

EUROPEAN GERIATRIC MEDICINE Vol. 15 ( 4 ) page： 1119 - 1127 2024.3

Relationship between cognitive function and phase angle measured with a bioelectrical impedance system

Yamada, Y; Watanabe, K; Fujisawa, C; Komiya, H; Nakashima, H; Tajima, T; Umegaki, H

EUROPEAN GERIATRIC MEDICINE Vol. 15 ( 1 ) page： 201 - 208 2024.2

Muscle ultrasound and its application to point-of-care ultrasonography: a narrative review

Nagae, M; Umegaki, H; Yoshiko, A; Fujita, K

ANNALS OF MEDICINE Vol. 55 ( 1 ) page： 190 - 197 2023.12

Comparing prevalence and types of potentially inappropriate medications among patient groups in a post-acute and secondary care hospital

Nakashima, H; Ando, H; Umegaki, H

SCIENTIFIC REPORTS Vol. 13 ( 1 ) page： 14543 2023.9

Cathepsin S activity controls chronic stress-induced muscle atrophy and dysfunction in mice

Wan, Y; Piao, LM; Xu, SN; Meng, XK; Huang, Z; Inoue, A; Wang, HL; Yue, XL; Jin, XY; Nan, YS; Shi, GP; Murohara, T; Umegaki, H; Kuzuya, M; Cheng, XW

CELLULAR AND MOLECULAR LIFE SCIENCES Vol. 80 ( 9 ) page： 254 2023.9

Combined use of the Clinical Frailty Scale and laboratory tests in acutely hospitalized older patients

Nakashima, H; Nagae, M; Komiya, H; Fujisawa, C; Watanabe, K; Yamada, Y; Tajima, T; Miyahara, S; Sakai, T; Umegaki, H

AGING CLINICAL AND EXPERIMENTAL RESEARCH Vol. 35 ( 9 ) page： 1927 - 1935 2023.9

Intrinsic capacity in acutely hospitalized older adults

Nagae, M; Umegaki, H; Komiya, H; Nakashima, H; Fujisawa, C; Watanabe, K; Yamada, Y; Miyahara, S

EXPERIMENTAL GERONTOLOGY Vol. 179 page： 112247 2023.8

COVID-19 pandemic increased the risk of prescribing potentially inappropriate medications to older adults

Suzuki, Y; Shiraishi, N; Komiya, H; Sakakibara, M; Akishita, M; Umegaki, H

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 23 ( 7 ) page： 579 - 581 2023.7

Dehydration and hospital-associated disability in acute hospitalized older adults

Nagae, M; Umegaki, H; Komiya, H; Fujisawa, C; Watanabe, K; Yamada, Y; Miyahara, S

EUROPEAN GERIATRIC MEDICINE Vol. 14 ( 1 ) page： 113 - 121 2023.2

Early-onset Alzheimer Disease Associated With Neuromyelitis Optica Spectrum Disorder

Fujisawa, C; Saji, N; Takeda, A; Kato, T; Nakamura, A; Sakurai, K; Asanomi, Y; Ozaki, K; Takada, K; Umegaki, H; Kuzuya, M; Sakurai, T

ALZHEIMER DISEASE & ASSOCIATED DISORDERS Vol. 37 ( 1 ) page： 85 - 87 2023.1

Clinical significance of geriatric conditions in acute hospitalization

Umegaki, H; Nagae, M; Komiya, H; Watanabe, K; Yamada, Y; Sakai, T; Tajima, T

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 23 ( 1 ) page： 50 - 53 2023.1

Relationship Between Non-Cognitive Intrinsic Capacity and Activities of Daily Living According to Alzheimer's Disease Stage

Fujisawa, C; Umegaki, H; Sugimoto, T; Nakashima, H; Nagae, M; Komiya, H; Watanabe, K; Yamada, Y; Sakurai, T

JOURNAL OF ALZHEIMERS DISEASE Vol. 96 ( 3 ) page： 1115 - 1127 2023

Young bone marrow transplantation prevents aging-related muscle atrophy in a senescence-accelerated mouse prone 10 model

Inoue, A; Piao, LM; Yue, XL; Huang, Z; Hu, LN; Wu, HX; Meng, XK; Xu, WH; Yu, CL; Sasaki, T; Itakura, K; Umegaki, H; Kuzuya, M; Cheng, XW

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE Vol. 13 ( 6 ) page： 3078 - 3090 2022.12

Association between changes in frailty during hospitalization in older adults and 3-month mortality after discharge

Umegaki, H; Nagae, M; Komiya, H; Watanabe, K; Yamada, Y; Sakai, T

EUROPEAN GERIATRIC MEDICINE Vol. 13 ( 6 ) page： 1403 - 1406 2022.12

Selection of chemotherapy for older patients with pancreatic cancer based on geriatric assessment

Maeda, O; Matsuoka, A; Yanagawa, M; Muroyama, Y; Watanabe, K; Liang, Y; Ishikawa, T; Ohno, E; Kawashima, H; Umegaki, H; Kuzuya, M; Ando, Y

JOURNAL OF GERIATRIC ONCOLOGY Vol. 13 ( 8 ) page： 1260 - 1263 2022.11

Japan Geriatrics Society "Statement for the use of telemedicine in geriatric care: Telemedicine as a complement to in-person medical practice": Geriatric Medical Practice Committee consensus statement

Nomura, K; Ebihara, S; Ikebata, Y; Umegaki, H; Ooi, K; Ogawa, S; Katsuya, T; Kobayashi, Y; Sakurai, T; Miyao, M; Yamaguchi, K; Akishita, M

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 22 ( 11 ) page： 913 - 916 2022.11

Relationship of creatinine cystatin C ratio with muscle mass and grip strength in memory clinic outpatients

Yamada, Y; Umegaki, H; Sugimoto, T; Nagae, M; Komiya, H; Watanabe, K; Sakurai, T

EXPERIMENTAL GERONTOLOGY Vol. 168 page： 111935 2022.10

Muscle changes on muscle ultrasound and adverse outcomes in acute hospitalized older adults

Nagae, M; Umegaki, H; Yoshiko, A; Fujita, K; Komiya, H; Watanabe, K; Yamada, Y; Sakai, T; Kuzuya, M

NUTRITION Vol. 102 page： 111698 2022.10

Muscle Evaluation and Hospital-Associated Disability in Acute Hospitalized Older Adults

Nagae, M; Umegaki, H; Yoshiko, A; Fujita, K; Komiya, H; Watanabe, K; Yamada, Y; Sakai, T

JOURNAL OF NUTRITION HEALTH & AGING Vol. 26 ( 7 ) page： 681 - 687 2022.7

Association between gait speed and errors on the Clock Drawing Test in older adults with mild cognitive impairment

Umegaki, H; Suzuki, Y; Komiya, H; Watanabe, K; Nagae, M; Yamada, Y; Kuzuya, M

SCIENTIFIC REPORTS Vol. 12 ( 1 ) page： 9929 2022.6

Older adults with a higher frailty index tend to have electrolyte imbalances

Fujisawa, C; Umegaki, H; Sugimoto, T; Huang, CH; Fujisawa, H; Sugimura, Y; Kuzuya, M; Toba, K; Sakurai, T

EXPERIMENTAL GERONTOLOGY Vol. 163 page： 111778 2022.6

In Response to Study Results Concerning the Impact of Antidepressants in Older Adults With Major Depressive Disorder Relating to Frailty

Sakai, T; Shiroshita, A; Momosaki, R; Umegaki, H

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES Vol. 77 ( 5 ) page： 1063 - 1064 2022.5

Mantle cell lymphoma with aseptic meningitis mimicking hydrocephalus on brain imaging

Samizo, S; Furukawa, K; Umegaki, H

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 84 ( 2 ) page： 470 - 476 2022.5

Clinical characteristics of older adults with hypertension and unrecognized cognitive impairment

Yamamoto, K; Akasaka, H; Yasunobe, Y; Shimizu, A; Nomoto, K; Nagai, K; Umegaki, H; Akasaki, Y; Kojima, T; Kozaki, K; Kuzuya, M; Ohishi, M; Akishita, M; Takami, Y; Rakugi, H

HYPERTENSION RESEARCH Vol. 45 ( 4 ) page： 612 - 619 2022.4

Physical Activity and Neurodegeneration in Older Adults: Comment on: "Associations Between Physical Activity, Blood-Based Biomarkers of Neurodegeneration and Cognition in Healthy Older Adults: The MAPT Study"

Umegaki, H

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES Vol. 77 ( 1 ) page： E34 - E35 2022.1

Impact of Sarcopenia on Decline in Quality of Life in Older People with Mild Cognitive Impairment

Umegaki, H; Suzuki, Y; Komiya, H; Watanabe, K; Nagae, M; Yamada, Y

JOURNAL OF ALZHEIMERS DISEASE Vol. 88 ( 1 ) page： 23 - 27 2022

Short- and long-term effects of different exercise programs on the gait performance of older adults with subjective cognitive decline: A randomized controlled trial

Fujita, K; Umegaki, H; Makino, T; Uemura, K; Hayashi, T; Inoue, A; Uno, C; Kitada, T; Huang, CH; Shimada, H; Kuzuya, M

EXPERIMENTAL GERONTOLOGY Vol. 156 page： 111590 2021.12

Active Life for Brain Health: A Narrative Review of the Mechanism Underlying the Protective Effects of Physical Activity on the Brain

Umegaki, H; Sakurai, T; Arai, H

FRONTIERS IN AGING NEUROSCIENCE Vol. 13 page： 761674 2021.11

Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice

Goto, H; Inoue, A; Piao, LM; Hu, LN; Huang, Z; Meng, XK; Suzuki, Y; Umegaki, H; Kuzuya, M; Cheng, XW

STEM CELLS INTERNATIONAL Vol. 2021 page： 9202990 2021.11

Relationships between overactive bladder and cerebral white matter hyperintensity in outpatients at a memory clinic

Komiya, H; Umegaki, H; Ogama, N; Sakurai, T; Kuzuya, M

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 21 ( 11 ) page： 996 - 1002 2021.11

Association of dehydration with development of dementia among non-demented geriatric outpatients

Nagae, M; Umegaki, H; Suzuki, Y; Komiya, H; Watanabe, K; Yamada, Y; Kuzuya, M

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 21 ( 10 ) page： 963 - 964 2021.10

The Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT): The Study Protocol for an 18-Month, Multicenter, Randomized, Controlled Trial

Sugimoto, T; Sakurai, T; Akatsu, H; Doi, T; Fujiwara, Y; Hirakawa, A; Kinoshita, F; Kuzuya, M; Lee, S; Matsuo, K; Michikawa, M; Ogawa, S; Otsuka, R; Sato, K; Shimada, H; Suzuki, H; Suzuki, H; Takechi, H; Takeda, S; Umegaki, H; Wakayama, S; Arai, H

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE Vol. 8 ( 4 ) page： 465 - 476 2021.9

Association of verbal fluency test with progression to dementia in non-demented older adults. Invited Reviewed

Umegaki H, Suzuki Y.

Vol. 21 ( 9 ) page： 868 - 869 2021.9

Echo intensity is more useful in predicting hospital-associated complications than conventional sarcopenia-related parameters in acute hospitalized older patients

Nagae, M; Umegaki, H; Yoshiko, A; Fujita, K; Komiya, H; Watanabe, K; Yamada, Y; Kuzuya, M; Leeuwenburgh, C

EXPERIMENTAL GERONTOLOGY Vol. 150 page： 111397 2021.7

The Multi-Domain Intervention Trial in Older Adults With Diabetes Mellitus for Prevention of Dementia in Japan: Study Protocol for a Multi-Center, Randomized, 18-Month Controlled Trial

Sugimoto, T; Araki, A; Fujita, H; Honda, K; Inagaki, N; Ishida, T; Kato, J; Kishi, M; Kobayashi, K; Kouyama, K; Noma, H; Ohishi, M; Satoh-Asahara, N; Shimada, H; Sugimoto, K; Suzuki, S; Takeya, Y; Tamura, Y; Tokuda, H; Umegaki, H; Watada, H; Yamada, Y; Sakurai, T

FRONTIERS IN AGING NEUROSCIENCE Vol. 13 page： 680341 2021.7

Chronic Effects of a Static Stretching Program on Hamstring Strength

Nakao, S; Ikezoe, T; Nakamura, M; Umegaki, H; Fujita, K; Umehara, J; Kobayashi, T; Ibuki, S; Ichihashi, N

JOURNAL OF STRENGTH AND CONDITIONING RESEARCH Vol. 35 ( 7 ) page： 1924 - 1929 2021.7

Functional categories based on cognition and activities of daily living predict all-cause mortality in older adults with diabetes mellitus: The Japanese Elderly Diabetes Intervention Trial

Omura, T; Tamura, Y; Sakurai, T; Umegaki, H; Iimuro, S; Ohashi, Y; Ito, H; Araki, A

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 21 ( 6 ) page： 512 - 518 2021.6

Effect of Various Exercises on Intrinsic Capacity in Older Adults With Subjective Cognitive Concerns.

Huang CH, Umegaki H, Makino T, Uemura K, Hayashi T, Kitada T, Inoue A, Shimada H, Kuzuya M

Journal of the American Medical Directors Association Vol. 22 ( 4 ) page： 780 - + 2021.4

Determinants and impact of physical impairment in patient-reported outcomes among older patients with type 2 diabetes mellitus in Japan.

Araki A, Umegaki H, Sakurai T, Mizuno Y, Miyao M, Imori M, Suzuki S, Cambron-Mellott MJ, Yokote K, Onuma T, Yokono K

Current medical research and opinion Vol. 37 ( 3 ) page： 393 - 402 2021.3

Association of fear of falling with cognitive function and physical activity in older community-dwelling adults

Umegaki Hiroyuki, Uemura Kazuki, Makino Taeko, Hayashi Takahiro, Cheng Xian Wu, Kuzuya Masafumi

EUROPEAN GERIATRIC MEDICINE Vol. 12 ( 1 ) page： 99 - 106 2021.2

Mild hyponatremia is associated with low skeletal muscle mass, physical function impairment, and depressive mood in the elderly

Fujisawa, C; Umegaki, H; Sugimoto, T; Samizo, S; Huang, CH; Fujisawa, H; Sugimura, Y; Kuzuya, M; Toba, K; Sakurai, T

BMC GERIATRICS Vol. 21 ( 1 ) page： 15 2021.1

Mental Health Status of the Older Adults in Japan During the COVID-19 Pandemic

Fujita, K; Inoue, A; Kuzuya, M; Uno, C; Huang, CH; Umegaki, H; Onishi, J

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION Vol. 22 ( 1 ) page： 220 - 221 2021.1

Frequencies and Neuropsychological Characteristics of Errors in the Clock Drawing Test

Umegaki, H; Suzuki, Y; Komiya, H; Watanabe, K; Yamada, Y; Nagae, M; Kuzuya, M

JOURNAL OF ALZHEIMERS DISEASE Vol. 82 ( 3 ) page： 1291 - 1300 2021

Effects of Aerobic, Resistance, or Combined Exercise Training Among Older Adults with Subjective Memory Complaints: A Randomized Controlled Trial

Makino, T; Umegaki, H; Ando, M; Cheng, XW; Ishida, K; Akima, H; Oshida, Y; Yoshida, Y; Uemura, K; Shimada, H; Kuzuya, M

JOURNAL OF ALZHEIMERS DISEASE Vol. 82 ( 2 ) page： 701 - 717 2021

Cross-Sectional Examination of Homocysteine Levels with Sarcopenia and Its Components in Memory Clinic Outpatients

Yamada, Y; Umegaki, H; Kinoshita, F; Huang, CH; Sugimoto, T; Fujisawa, C; Komiya, H; Watanabe, K; Nagae, M; Kuzuya, M; Sakurai, T

JOURNAL OF ALZHEIMERS DISEASE Vol. 82 ( 3 ) page： 975 - 984 2021

Associations Between Polypharmacy and Gait Speed According to Cognitive Impairment Status: Cross-Sectional Study in a Japanese Memory Clinic

Watanabe, K; Umegaki, H; Sugimoto, T; Fujisawa, C; Komiya, H; Nagae, M; Yamada, Y; Kuzuya, M; Sakurai, T; Stirland, L

JOURNAL OF ALZHEIMERS DISEASE Vol. 82 ( 3 ) page： 1115 - 1122 2021

FRAILTY IN A FRAILTY PREVENTION PROGRAM PARTICIPANTS DURING COVID-19 PANDEMIC: A CROSS-SECTIONAL JAPANESE STUDY

Kanamori, T; Suzuki, M; Naito, T; Inagaki, K; Umegaki, H

INNOVATION IN AGING Vol. 5 page： 816 - 816 2021

HOme-based Longitudinal Investigation of the multidiSciplinary Team Integrated Care (HOLISTIC): protocol of a prospective nationwide cohort study.

Liao JY, Chen PJ, Wu YL, Cheng CH, Yu SJ, Huang CH, Li CM, Wang YW, Zhang KP, Liu IT, Umegaki H, Hamano J, Mori M, Petersen I, Sampson EL, Hsiung CA

BMC geriatrics Vol. 20 ( 1 ) page： 511 2020.12

Effect of various exercises on frailty among older adults with subjective cognitive concerns: a randomised controlled trial.

Huang CH, Umegaki H, Makino T, Uemura K, Hayashi T, Kitada T, Inoue A, Shimada H, Kuzuya M

Age and ageing Vol. 49 ( 6 ) page： 1011 - 1019 2020.11

Chronic Dehydration in Nursing Home Residents.

Nagae M, Umegaki H, Onishi J, Huang CH, Yamada Y, Watanabe K, Komiya H, Kuzuya M

Nutrients Vol. 12 ( 11 ) 2020.11

Association of the Qualitative Clock Drawing Test with Progression to Dementia in Non-Demented Older Adults.

Umegaki H, Suzuki Y, Yamada Y, Komiya H, Watanabe K, Nagae M, Kuzuya M

Journal of clinical medicine Vol. 9 ( 9 ) page： 2850 2020.9

Association of polypharmacy with decline in quality of life in mild cognitive impairment and mild dementia

Umegaki Hiroyuki

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 20 ( 9 ) page： 840 - 842 2020.9

Association Between Sarcopenia and Quality of Life in Patients with Early Dementia and Mild Cognitive Impairment.

Vol. 76 ( 1 ) page： 435-442 2020.5

A Study on the Relationship between Cognitive Performance, Hearing Impairment, and Frailty in Older Adults.

Bonfiglio V, Umegaki H, Kuzuya M

Dementia and geriatric cognitive disorders Vol. 49 ( 2 ) page： 156-162 2020.4

Combined Impact of Physical Frailty and Social Isolation on Rate of Falls in Older Adults

Hayashi T., Umegaki Hiroyuki, Makino T., Huang C. H., Inoue A., Shimada H., Kuzuya M.

JOURNAL OF NUTRITION HEALTH & AGING Vol. 24 ( 3 ) page： 312 - 318 2020.3

Falls in community-dwelling prefrail older adults

Umegaki Hiroyuki, Makino Taeko, Uemura Kazuki, Shimada Hiroyuki, Cheng Xian Wu, Dodge Hiroko, Kuzuya Masafumi

HEALTH & SOCIAL CARE IN THE COMMUNITY Vol. 28 ( 1 ) page： 110 - 115 2020.1

Assessing the association between optimal energy intake and all-cause mortality in older patients with diabetes mellitus using the Japanese Elderly Diabetes Intervention Trial

Omura Takuya, Tamura Yoshiaki, Yamaoka Takuya, Yoshimura Yukio, Sakurai Takashi, Umegaki Hiroyuki, Kamada Chiemi, Iimuro Satoshi, Ohashi Yasuo, Ito Hideki, Araki Atsushi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 20 ( 1 ) page： 59 - 65 2020.1

[Malignant lymphoma with IgG4-related disease arising in a very elderly man].

Nagae M, Onishi J, Umegaki H, Kuzuya M

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics Vol. 57 ( 3 ) page： 321-326 2020

Cathepsin S-Mediated Negative Regulation of Wnt5a/SC35 Activation Contributes to Ischemia-Induced Neovascularization in Aged Mice

Xu Wenhu, Yu Chenglin, Piao Limei, Inoue Aiko, Wang Hailong, Meng Xiangkun, Li Xiang, Cui Lan, Umegaki Hiroyuki, Shi Guo-Ping, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

CIRCULATION JOURNAL Vol. 83 ( 12 ) page： 2537 - + 2019.12

Plasma orexin-A levels in patients with delirium.

Nakashima H, Umegaki H, Yanagawa M, Komiya H, Watanabe K, Kuzuya M

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society Vol. 19 ( 6 ) page： 628-630 2019.11

Quality of life in cognitively impaired older adults

Bonfiglio Viviana, Umegaki Hiroyuki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 19 ( 10 ) page： 999 - 1005 2019.10

Association between dysphagia risk and unplanned hospitalization in older patients receiving home medical care

Watanabe Kazuhisa, Umegaki Hiroyuki, Huang Chi-Hsien, Arakawa Martins Beatriz, Asai Atsushi, Kanda Shigeru, Nomura Hideki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 19 ( 10 ) page： 977 - 981 2019.10

Higher and Lower Muscle Echo Intensity in Elderly Individuals Is Distinguished by Muscle Size, Physical Performance and Daily Physical Activity.

Yoshiko Akito, Natsume Yukie, Makino Taeko, Hayashi Takahiro, Umegaki Hiroyuki, Yoshida Yasuko, Cheng Xian Wu, Kuzuya Masafumi, Ishida Koji, Koike Teruhiko, Oshida Yoshiharu, Akima Hiroshi

ULTRASOUND IN MEDICINE AND BIOLOGY Vol. 45 ( 9 ) page： 2372 - 2380 2019.9

Plasma orexin-A-like immunoreactivity levels and renal function in patients in a geriatric ward

Nakashima Hirotaka, Umegaki Hiroyuki, Yanagawa Madoka, Komiya Hitoshi, Watanabe Kazuhisa, Kuzuya Masafumi

PEPTIDES Vol. 118 page： 170092 2019.8

Relationship between blood coagulability and sense of burden among caregivers of patients with dementia

Hirano Akemi, Suzuki Yusuke, Umegaki Hiroyuki, Hayashi Toshio, Ina Koichiro, Onishi Joji, Hasegawa Jun, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 19 ( 8 ) page： 804 - 808 2019.8

Polypharmacy and gait speed in individuals with mild cognitive impairment

Umegaki Hiroyuki, Yanagawa Madoka, Komiya Hitoshi, Matsubara Masaki, Fujisawa Chisato, Suzuki Yusuke, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 19 ( 8 ) page： 730 - 735 2019.8

Cathepsin S Deficiency Mitigated Chronic Stress-Related Neointimal Hyperplasia in Mice

Wang Hailong, Meng Xiangkun, Piao Limei, Inoue Aiko, Xu Wenhu, Yu Chenglin, Nakamura Kae, Hu Lina, Sasaki Takeshi, Wu Hongxian, Unno Kazumasa, Umegaki Hiroyuki, Murohara Toyoaki, Shi Guo-Ping, Kuzuya Masafumi, Cheng Xian Wu

JOURNAL OF THE AMERICAN HEART ASSOCIATION Vol. 8 ( 14 ) page： e011994 2019.7

Response to the comments on "Sarcopenia and depressive mood in older adults"

Hayashi Takahiro, Umegaki Hiroyuki, Makino Taeko, Cheng Xian W., Shimada Hiroyuki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 19 ( 7 ) page： 690 - 691 2019.7

Association between sarcopenia and depressive mood in urban-dwelling older adults: A cross-sectional study

Hayashi Takahiro, Umegaki Hiroyuki, Makino Taeko, Cheng Xian W., Shimada Hiroyuki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 19 ( 6 ) page： 508 - 512 2019.6

Prevalence and risk factors of constipation and pollakisuria among older home-care patients

Komiya Hitoshi, Umegaki Hiroyuki, Asai Atsushi, Kanda Shigeru, Maeda Keiko, Nomura Hideki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 19 ( 4 ) page： 277 - 281 2019.4

[Diabetes Mellitus and Dementia].

Umegaki H

Brain and nerve = Shinkei kenkyu no shinpo Vol. 71 ( 4 ) page： 409-414 2019.4

Association of Glucose Fluctuations with Sarcopenia in Older Adults with Type 2 Diabetes Mellitus

Ogama Noriko, Sakurai Takashi, Kawashima Shuji, Tanikawa Takahisa, Tokuda Haruhiko, Satake Shosuke, Miura Hisayuki, Shimizu Atsuya, Kokubo Manabu, Niida Shumpei, Toba Kenji, Umegaki Hiroyuki, Kuzuya Masafumi

JOURNAL OF CLINICAL MEDICINE Vol. 8 ( 3 ) page： 319 2019.3

Potentially inappropriate medications according to STOPP-J criteria and risks of hospitalization and mortality in elderly patients receiving home-based medical services

Huang Chi-Hsien, Umegaki Hiroyuki, Watanabe Yuuki, Kamitani Hiroko, Asai Atushi, Kanda Shigeru, Nomura Hideki, Kuzuya Masafumi

PLOS ONE Vol. 14 ( 2 ) page： e0211947 2019.2

Complaint of poor night sleep is correlated with physical function impairment in mild Alzheimer's disease patients

Fujisawa Chisato, Umegaki Hiroyuki, Nakashima Hirotaka, Kuzuya Masafumi, Toba Kenji, Sakurai Takashi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 19 ( 2 ) page： 171 - 172 2019.2

Change in quality of life and potentially associated factors in patients receiving home-based primary care: a prospective cohort study

Huang Chi-Hsien, Umegaki Hiroyuki, Kamitani Hiroko, Asai Atushi, Kanda Shigeru, Maeda Keiko, Nomura Hideki, Kuzuya Masafumi

BMC GERIATRICS Vol. 19 ( 1 ) page： 21 2019.1

Potentially Inappropriate Medications and Polypharmacy: A Study of Older People with Mild Cognitive Impairment and Mild Dementia.

Bonfiglio V, Umegaki H, Kuzuya M

Vol. 71 ( 3 ) page： 889-897 2019

Potentially Inappropriate Medications and Polypharmacy: A Study of Older People with Mild Cognitive Impairment and Mild Dementia

Bonfiglio Viviana, Umegaki Hiroyuki, Kuzuya Masafumi

JOURNAL OF ALZHEIMERS DISEASE Vol. 71 ( 3 ) page： 889 - 897 2019

Postprandial Hyperglycemia Is Associated With White Matter Hyperintensity and Brain Atrophy in Older Patients With Type 2 Diabetes Mellitus

FRONTIERS IN AGING NEUROSCIENCE Vol. 10 page： 273 2018.9

Maximum gait speed is associated with a wide range of cognitive functions in Japanese older adults with a Clinical Dementia Rating of 0.5. Reviewed

Umegaki H, Makino T, Yanagawa M, Nakashima H, Kuzuya M, Sakurai T, Toba K.

Geriatr Gerontol Int. Vol. 18 ( 9 ) page： 1323-1329 2018.9

Diabetes-related cognitive dysfunction: Hyperglycemia in the early stage might be a key? Reviewed

Umegaki H

J Diabetes Investig. Vol. 9 ( 5 ) page： 1019-1021 2018.9

Association between insulin resistance and objective measurement of physical activity in community-dwelling older adults without diabetes mellitus

Umegaki Hiroyuki, Makino Taeko, Uemura Kazuki, Shimada Hiroyuki, Hayashi Takahiro, Cheng Xian Wu, Kuzuya Masafumi

DIABETES RESEARCH AND CLINICAL PRACTICE Vol. 143 page： 267 - 274 2018.9

Maximum gait speed is associated with a wide range of cognitive functions in Japanese older adults with a Clinical Dementia Rating of 0.5

Umegaki Hiroyuki, Makino Taeko, Yanagawa Madoka, Nakashima Hirotaka, Kuzuya Masafumi, Sakurai Takashi, Toba Kenji

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 18 ( 9 ) page： 1323 - 1329 2018.9

Umegaki Hiroyuki

JOURNAL OF DIABETES INVESTIGATION Vol. 9 ( 5 ) page： 1019 - 1021 2018.9

Correlation between regional cerebral blood flow and body composition in cognitively healthy elderly women: a SPECT study. Reviewed

Fujisawa C, Umegaki H, Kato T, Nakashima H, Kuzuya M, Ito K, Toba K, Sakurai T

Geriatr Gerontol Int Vol. 18 ( 8 ) page： 1303-1304 2018.8

Correlation between regional cerebral blood flow and body composition in healthy older women: A single-photon emission computed tomography study

Fujisawa Chisato, Umegaki Hiroyuki, Kato Takashi, Nakashima Hirotaka, Kuzuya Masafumi, Ito Kengo, Toba Kenji, Sakurai Takashi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 18 ( 8 ) page： 1303 - 1304 2018.8

Association between insulin resistance and objective measurement of physical activity in community-dwelling older adults without diabetes mellitus. Reviewed

Umegaki H, Makino T, Uemura K, Shimada H, Hayashi T, Cheng X W, Kuzuya M.

Diabetes Res Clin Pract Vol. 143 page： 267 2018.7

基礎・臨床研究の最新動向　Ⅴ.高齢者へのアプローチ　高齢者病態の特徴

梅垣宏行

日本臨床 Vol. 76 ( 5 ) page： 299～304 2018.6

Frontal white matter hyperintensity is associated with verbal aggressiveness in elderly women with alzheimer disease and amnestic nils cognitive impairment. Reviewed

Ogama N, Sakurai T, Saji N, Nakai T, Niida S, Toba K, Umegaki H, Kuzuya M

Dement Geriatr Cogn Disord Extra Vol. 8 ( 1 ) page： 138-150 2018.4

Cilostazol for the prevention of pneumonia: a systematic review. Reviewed

Nakashima H, Watanabe K, Umegaki H, Suzuki Y, Kuzuya M.

Pneumonia Vol. 10 page： 3 2018.4

Cognitive Dysfunction in Urban-Community Dwelling Prefrail Older Subjects. Reviewed

Umegaki H, Makino T, Shimada H, Hayashi T, Wu Cheng X, Kuzuya M.

J Nutr Health Aging Vol. 22 ( 4 ) page： 549-554 2018.4

高齢者医療ハンドブック-高齢者医療におけるダイバーシティへの対応】(第II章)高齢者と老年症候群やせ(解説/特集)

梅垣宏行

㈱南江堂 Vol. 121 ( 4 ) page： 645-648 2018.4

Cognitive Dysfunction in Urban-Community Dwelling Prefrail Older Subjects

Umegaki H., Makino T., Shimada H., Hayashi T., Cheng X. Wu, Kuzuya M.

JOURNAL OF NUTRITION HEALTH & AGING Vol. 22 ( 4 ) page： 549 - 554 2018.4

病気とくすり2018　基礎と実践Expert’s Guide 精神・中枢神経の病気とくすり　認知症

梅垣宏行、渡邉雄貴、山田清文

薬局 Vol. 69 ( 4 ) page： 738-746 2018.3

Objectively measured physical activity and cognitive function in urban-dwelling older subjects Reviewed

Umegaki H, Makino T, Uemura K, Shimada H, Cheng X W, Kuzuya M.

Geriatr Gerontol Int Vol. 18 ( 6 ) page： 922-928 2018.2

Cathepsin K activity controls cardiotoxin-induced skeletal muscle repair in mice. Reviewed

Ogasawara S, Cheng XW, Inoue A, Hu L, Piao L, Yu C, Goto H, Xu W, Zhao G, Lei Y, Yang G, Kimura K, Umegaki H, Shi GP, Kuzuya M.

J Cachexia Sarcopenia Muscle Vol. 9 ( 1 ) page： 160–175 2018.2

高齢者の総合機能評価

梅垣宏行,葛谷雅文

救急医学 Vol. 42 ( 2 ) page： 204～209 2018.2

Cathepsin K activity controls cardiotoxin-induced skeletal muscle repair in mice

Ogasawara Shinyu, Cheng Xian Wu, Inoue Aiko, Hu Lina, Piao Limei, Yu Chenglin, Goto Hiroki, Xu Wenhu, Zhao Guangxian, Lei Yanna, Yang Guang, Kimura Kaoru, Umegaki Hiroyuki, Shi Guo-Ping, Kuzuya Masafumi

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE Vol. 9 ( 1 ) page： 160 - 175 2018.2

Factors associated with polypharmacy in elderly home-care patients

Komiya H, Umegaki H, Atsushi A, Kanda S, Maeda K, Shimojima T, Nomura H, Kuzuya M

Geriatr Gerontol Int. Vol. 18 ( 1 ) page： 33-41 2018.1

在宅医療を受ける高齢者のQOL (quality of life) 評価票における本人と介護者による代理評価の回答の一致性の検討

紙谷博子、梅垣宏行、岡本和士、神田茂、浅井真嗣、下島卓弥、野村秀樹、服部文子、木股貴哉、鈴木裕介、大島浩子、葛谷雅文

日本老年医学会雑誌 Vol. 55 ( 1 ) page： 98-105 2018.1

脳波データを用いたMMSEスコアの推定に関する検討

三輪晃暉、高倉健太郎、吉川大弘、古橋　武、寶珠山　稔、牧野多恵子、柳川まどか、鈴木裕介、梅垣宏行、葛谷雅文

信学技報 Vol. 117 ( 417 ) page：信学技報 2018.1

Effects of a Thermal Agent and Physical Activity on Muscle Tendon Stiffness, as Well as the Effects Combined With Static Stretching

Fujita Kosuke, Nakamura Masatoshi, Umegaki Hiroki, Kobayashi Takuya, Nishishita Satoru, Tanaka Hiroki, Ibuki Satoko, Ichihashi Noriaki

JOURNAL OF SPORT REHABILITATION Vol. 27 ( 1 ) page： 66 - 72 2018.1

Frontal White Matter Hyperintensity Is Associated with Verbal Aggressiveness in Elderly Women with Alzheimer Disease and Amnestic Mild Cognitive Impairment

Ogama Noriko, Sakurai Takashi, Saji Naoki, Nakai Toshiharu, Niida Shumpei, Toba Kenji, Umegaki Hiroyuki, Kuzuya Masafumi

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA Vol. 8 ( 1 ) page： 138 - 150 2018.1

Factors associated with polypharmacy in elderly home-care patients

Komiya Hitoshi, Umegaki Hiroyuki, Asai Atsushi, Kanda Shigeru, Maeda Keiko, Shimojima Takuya, Nomura Hideki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 18 ( 1 ) page： 33 - 41 2018.1

Study on Estimation of MMSE Score by Using the Latency of P300 and Alpha Wave

Miwa Koki, Yoshikawa Tomohiro, Furuhashi Takeshi, Hoshiyama Minoru, Makino Taeko, Yanagawa Madoka, Suzuki Yusuke, Umegaki Hiroyuki, Kuzuya Masafumi

2018 JOINT 10TH INTERNATIONAL CONFERENCE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS (SCIS) AND 19TH INTERNATIONAL SYMPOSIUM ON ADVANCED INTELLIGENT SYSTEMS (ISIS) page： 195 - 199 2018

Cilostazol for the prevention of pneumonia: a systematic review

Nakashima Hirotaka, Watanabe Kazuhisa, Umegaki Hiroyuki, Suzuki Yusuke, Kuzuya Masafumi

PNEUMONIA Vol. 10 page： 3 2018

[Agreement in the responses to self-reported and proxy-reported versions of QOL-HC: a new quality-of-life scale for patients receiving home-based medical care].

Kamitani H, Umegaki H, Okamoto K, Kanda S, Asai A, Shimojima T, Nomura H, Hattori A, Kimata T, Suzuki Y, Ohshima H, Kuzuya M

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics Vol. 55 ( 1 ) page： 98-105 2018

高齢糖尿病患者における血糖コントロールの現状

服部孝二、梅垣宏行、小宮　仁、渡邊一久、葛谷雅文

日老医誌 Vol. 54 page： 531-536 2017.12

Authors' reply to the letter by Esra et al

Umegaki H, Nonogaki Z, Makino T, Suzuki Y, Kuzuya M

Geriatr Gerontol Int. Vol. 17 ( 11 ) page： 2284-2285 2017.11

高齢者とインスリン分泌促進薬

梅垣宏行

糖尿病の最新治療 Vol. 9 ( 1 ) page： 32-36 2017.11

Ⅲ．高齢者糖尿病の管理・治療上の留意点３．薬物療法（2）経口血糖降下薬使用時の留意点

梅垣宏行

高齢者糖尿病 Vol. 75 ( 11 ) page： 1689 2017.11

Authors' reply to the letter by Esra et al

Umegaki Hiroyuki, Nonogaki Zen, Makino Taeko, Suzuki Yusuke, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 17 ( 11 ) page： 2284 - 2285 2017.11

（質疑応答）塩酸ドネペジルの認知症症状の進行抑制効果とは？

梅垣宏行

日本医事新報 page： 59 2017.10

Factors associated with unexpected admissions and mortality among low-functioning older patients receiving home medical care.

Umegaki H, Asai A, Kanda S, Maeda K, Shimojima T, Nomura H, Kuzuya M.

Geriatr Gerontol Int Vol. 17 ( 10 ) page： 1623-1627 2017.10

認知機能の評価と対応

梅垣宏行　

月刊糖尿病 Vol. 9 ( 9 ) page： 28-33 2017.9

Low intakes of carotene, vitamin B2, pantothenate, and calcium predict cognitive decline among elderly patients with diabetes mellitus: the Japanese Elderly Diabetes Intervention Trial Research Group.

Araki A, Yoshimura Y, Sakurai T, Umegaki H, Kamada C, Iimuro S, Ohashi Y, Ito H; Japanese Elderly Diabetes Intervention Trial Research Group.

Geriatr Gerontol Int. Vol. 17 ( 8 ) page： 1168 - 1175 2017.8

高齢者糖尿病のインスリンの使用法

梅垣宏行

Geriatric Med. Vol. 55 ( 8 ) page： 905-908 2017.8

高齢者糖尿病の血糖管理目標について

梅垣宏行

Medical Practice Vol. 34 ( 6 ) page： 1044 2017.6

高齢者糖尿病患者の食事・運動療法がわからない！？

梅垣宏行、葛谷雅文

Diabetes　Strategy Vol. 7 ( 5 ) page： 75-79 2017.5

Physical Function Differences Between the Stages From Normal Cognition to Moderate Alzheimer Disease.

Fujisawa C, Umegaki H, Okamoto K, Nakashima H, Kuzuya M, Toba K, Sakurai T.

J Am Med Dir Assoc. Vol. 18 ( 4 ) page： 368.e9-368.e15 2017.4

Physical Function Differences Between the Stages From Normal Cognition to Moderate Alzheimer Disease

Fujisawa Chisato, Umegaki Hiroyuki, Okamoto Kazushi, Nakashima Hirotaka, Kuzuya Masafumi, Toba Kenji, Sakurai Takashi

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION Vol. 18 ( 4 ) page： 368.e9 - 368.e15 2017.4

The associations among insulin resistance, hyperglycemia, physical performance, diabetes mellitus, and cognitive function in relatively healthy older adults with subtle cognitive dysfunction.

Umegaki H, Makino T, Uemura K, Shimada H, Hyashi T, Cheng XY, Kuzuya M.

Front aging neurosci. page： doi: 10.3389/fnagi.2017.00072. 2017.3

The Associations among Insulin Resistance, Hyperglycemia, Physical Performance, Diabetes Mellitus, and Cognitive Function in Relatively Healthy Older Adults with Subtle Cognitive Dysfunction

Umegaki Hiroyuki, Makino Taeko, Uemura Kazuki, Shimada Hiroyuki, Hayashi Takahiro, Cheng Xian Wu, Kuzuya Masafumi

FRONTIERS IN AGING NEUROSCIENCE Vol. 9 page： 72 2017.3

Impact of frontal white matter hyperintensity on instrumental activities of daily living in elderly women with Alzheimer disease and amnestic mild cognitive impairment.

Ogama N, Sakurai T, Nakai T, Niida S, Saji N, Toba K, Umegaki H, Kuzuya M.

PLoS One. Vol. 12 ( 3 ) page： e0172484 2017.3

Impact of frontal white matter hyperintensity on instrumental activities of daily living in elderly women with Alzheimer disease and amnestic mild cognitive impairment

Ogama Noriko, Sakurai Takashi, Nakai Toshiharu, Niida Shumpei, Saji Naoki, Toba Kenji, Umegaki Hiroyuki, Kuzuya Masafumi

PLOS ONE Vol. 12 ( 3 ) page： e0172484 2017.3

Development and validation of a new quality of life scale for patients receiving home-based medical care: The Observational Study of Nagoya Elderly with Home Medical Care.

Kamitani H, Umegaki H, Okamoto K, Kanda S, Asai A, Maeda K, Nomura H, Shimojima T, Suzuki Y, Ohshima H, Kuzuya M.

Geriatr Gerontol Int Vol. 17 ( 3 ) page： 440-448 2017.3

Association of blood pressure and cognitive decline in older adults with diabetes mellitus during a 9-year observational study.

Umegaki H, Kawamura T, Umemura T, Kawano N

Geriatr Gerontol Int. Vol. 17 ( 3 ) page： 514 - 515 2017.3

精神・神経系の病気とくすり　中枢系疾患認知症（解説／特集）

梅垣宏行、渡邉雄貴、山田清文

薬局 Vol. 68 ( 4 ) page： 740-748 2017.3

Association of blood pressure and cognitive decline in older adults with diabetes mellitus during a 9-year observational study

Umegaki Hiroyuki, Kawamura Takahiko, Umemura Toshitaka, Kawano Naoko

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 17 ( 3 ) page： 514-515 2017.3

Randomized,Double-blind Placebo-controlled Multicenter Trial of Yokukansan for Neuropsychiatric Symptoms in Alzheimer's Disease.

Furukawa K, Tomita N, Uematsu D, Okahara K, Shimada H, Ikeda M, Matsui T, Kozaki K, Fujii M, Ogawa T, Umegaki H, Urakami K, Nomura H, Kobayashi N, Nakanishi A, Washimi Y, Yonezawa H, Takahashi S, Kubota M, Wakutani Y, Ito D, Sasaki T, Matsubara E, Une K, Ishiki A, Yahagi Y, Shoji M, Sato H, Terayama Y, Kuzuya M, Araki N, Kodama M, Yamaguchi T, Arai H.

Geriatr Gerontol Int Vol. 17 ( 2 ) page： 211-218 2017.2

The relationship between cardiac autonomic function and cognitive function in Alzheimer's disease.

Nonogaki Z, Umegaki H, Makino T, Suzuk Y, Kuzuya M.

Geriatr Gerontol Int Vol. 17 ( 1 ) page： 92-98 2017.1

「差分解説欄」高齢者糖尿病の血糖コントロール目標

梅垣宏行

日本医事新報 page： 53 2017.1

糖尿病とサルコペニア・フレイルの関連

梅垣宏行

Geriat.Med. Vol. 55 ( 1 ) page： 41-43 2017.1

高齢者における糖尿病治療　Update

梅垣宏行、葛谷雅文

最新医学 Vol. 72 ( 1 ) page： 79～83 2017.1

[State of glycemic control in elderly diabetic patients].

Hattori K, Umegaki H, Komiya H, Watanabe K, Kuzuya M

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics Vol. 54 ( 4 ) page： 531-536 2017

Neuropsychological differences in Alzheimer's disease patients with or without type 2 diabetes mellitus.

Yanagawa M, Umegaki H, Makino T, Nakashima H, Kuzuya M.

Geriatr Gerontol Int Vol. 16 ( 11 ) page： 1232-1235 2016.11

糖尿病患者におけるフレイル・認知症

梅垣宏行

Medical Practice Vol. 33 ( 8 ) page： 1245-1248 2016.8

Araki A, Yoshimura Y, Sakurai T, Umegaki H, Kamada C, Iimuro S, Ohashi Y, Ito H; Japanese Elderly Diabetes Intervention Trial Research Group.

Geriatr Gerrontol Int 2016.7

Neuroanatomical correlates of error types on the Clock Drawing Test in Alzheimer's disease patients.

Nakashima H, Umegaki H, Makino T, Kato K, Abe S, Suzuki Y, Kuzuya M.

Geriatr Gerontol Int Vol. 16 ( 7 ) page： 777-784 2016.7

【超高齢社会における適正薬物療法の特質～ガイドラインの今日的役割と薬剤師の責務～】高齢者糖尿病の薬物療法

梅垣宏行

医療ジャーナル Vol. 52 ( 6 ) page： 1455-1458 2016.6

Therapeutic Potential of Antidiabetic Medications in the Treatment of Cognitive Dysfunction and Dementia.

Umegaki H.

Drugs Aging. Vol. 33 ( 6 ) page： 399-409 2016.6

Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain-immune interface.

Hasegawa-Ishii S, Inaba M, Umegaki H, Unnno K, Wakabayashi K, Shimada A.

Sci Rep. 2016.5

認知症の栄養と食事療法.

梅垣宏行

Geriatric Medicine (老年医学) Vol. 54 ( 5 ) page： 225-228 2016.5

新時代の臨床糖尿病学（下）―より良い血糖管理をめざして―XIV．ライフステージ別糖尿病3.高齢者糖尿病(4)高齢者糖尿病の検査・診断.

梅垣宏行

日本臨床 Vol. 74 ( 増刊　2 ) page： 547 2016.4

疾病予防・重症化予防栄養・運動による認知症の発症・重症化予防

梅垣宏行

臨床栄養　別冊セレクト11 　健康寿命延伸をめざす栄養戦略 page： 94-98 2016.4

認知症を合併した糖尿病の治療糖尿病治療の現在と未来.

梅垣宏行

診断と治療 Vol. 104 ( 増刊 ) page： 198-202 2016.3

Sarcopeina and frailty in older patients with diabetes mellitus.

Umegaki H

2016.3

Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain-immune interface.

Hasegawa-Ishii S, Inaba M, Umegaki H, Unno K, Wakabayashi K, Shimada A

Scientific Reports Vol. 5 ( 6 ) page： 25457 2016.3

精神・神経系の病気とくすり　中枢系疾患　認知症（解説／特集）

梅垣宏行、渡邉雄貴、山田清文

薬局　 Vol. 67 ( 4 ) page： 624-632 2016.3

Factors associated with changes in brain atrophy during a 3-year observation in elderly diabetic patients; Effect of renal impairment on hippocampal atrophy.

Kawamura T, Umemura T, Umegaki H, Imamine R, Kawano N, Mase H, Mizoguchi A, Minatoguchi M, Kusama M, Kouchi Y, Watarai A, Kanai A, Nakashima E, Hotta N.

Dement Geriatr Cogn Disord Extra Vol. 6 ( 1 ) page： 55-67 2016.2

認知症患者の生命予後

梅垣宏行、葛谷雅文

日本老年精神医学会誌 Vol. 27 ( 2 ) page： 146-151 2016.2

Development and validation of a new quality of life scale for patients receiving home-based medical care: The Observational Study of Nagoya Elderly with Home Medical Care.

Kamitani H, Umegaki H, Okamoto K, Kanda S, Asai A, Maeda K, Nomura H, Shimojima T, Suzuki Y, Ohshima H, Kuzuya M

Geriatr Gerontol Int. 2016.1

在宅医療における入院などに関連する因子の検討

梅垣宏行

日本老年医学会雑誌 Vol. 53 ( 1 ) page： 32-37 2016.1

特集　患者さんと医療者の不安を解決　認知症なんでもQ＆A ・認知症を予防するために何をすればよいですか。・認知症になったらもう治療法はないのですか。

梅垣宏行

糖尿病ケア Vol. 13 ( 1 ) page： 25-28 2016.1

Risk factors for the discontinuation of home medical care among low-functioning older patients

Umegaki H, Asai A, Kanda S, Maeda K, Shimojima T, Nomura H, Kuzuya M.

The Journal of Nutrition, Health and Aging, First online Vol. 20 ( 4 ) page： 453-457 2016

認知症患者の生命予後.

梅垣宏行、葛谷雅文

日本老年精神医学会誌 page： 146-151 2016

Effects of Mild Cognitive Impairment on the Development of Fear of Falling in Older Adults: A Prospective Cohort Study.

Uemura K, Shimada H, Makizako H, Doi T, Tsutsumimoto K, Lee S, Umegaki H, Kuzuya M, Suzuki T

J Am Med Dir Assoc 2015.12

Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease.

Geriatr Gerontol Int. 2015.12

The relationship between cardiac autonomic function and cognitive function in Alzheimer’s disease

Nonogaki Z, Umegaki H, Makino T, Suzuk Yi, Kuzuya M

2015.12

Sarcopenia and diabetes: Hyperglycemia is a risk factor for age-associated muscle mass and functional reduction.

Umegaki H

J Diabetes Investig Vol. 6 ( 6 ) page： 623-4 2015.11

糖尿病患者の神経心理学的異常

梅垣宏行

Progress in Medicine Vol. 35 ( 9 ) page： 57-62 2015.9

The prevalence of homebound individuals in the elderly population: a survey in a city area in Japan Reviewed

Umegaki H, Yanagawa M, Nakashima H, Makino T, Kuzuya M.

Nagoya Journal of Medical Science Vol. 77 ( 3 ) page： 439-446 2015.8

Effects of leisure activities at home on perceived care burden and the endocrine system of caregivers of dementia patients: a randomized controlled study.

Hirano A, Umegaki H, Suzuki Y, Hayashi T, Kuzuya M

Int Psychogeriatr Vol. 20 page： 1-8 2015.8

Neuroanatomical correlates of error types on the Clock Drawing Test in Alzheimer's disease patients. Reviewed

Nakashima H, Umegaki H, Makino T, Kato K, Abe S, Suzuki Y, Kuzuya M.

Geriatr Gerontol Int 2015.7

ロコモティブシンドロームのすべて　認知症とロコモ

梅垣宏行

医師会雑誌 Vol. 144 ( 特別号（1） ) page： 289-291 2015.6

高齢者糖尿病の食事・運動療法の進歩

梅垣宏行

Geriatric Medicine(老年医学) Vol. 53 ( 5 ) page： 457-460 2015.6

高齢者糖尿病の食事・運動療法の進歩.

梅垣宏行

Geriatric Medicine(老年医学) Vol. 53 ( 5 ) page： 457-460 2015.6

Q2 メモリークリニックとは？Q4 認知症の診断過程と鑑別は？

梅垣宏行

Medical Rehabilitation （2015年5月増刊号） Vol. 183 ( 増刊 ) page： 7-10,16-19 2015.5

Association of decrease in carbohydrate intake with reduction in abdominal fat during 3-month moderate low-carbohydrate diet among non-obese Japanese patients with type 2 diabetes.

Sasakabe T, Haimoto H, Umegaki H, Wakai K.

Geriatr Gerontol Int Vol. 64 ( 5 ) page： 618-25 2015.5

Dementia: Type 2 diabetes has a slow and insidious effect on cognition. Reviewed

Umegaki H.

Nat Rev Neurol. Vol. 11 ( 3 ) page： 127-8 2015.3

Association of decrease in carbohydrate intake with reduction in abdominal fat during 3-month moderate low-carbohydrate diet among non-obese Japanese patients with type 2 diabetes.

Sasakabe T,Haimoto H, Umegaki H, Wakai K.

Metabolism. Vol. 64 ( 5 ) page： 618-25 2015.3

特集　在宅医療の新しい展開／在宅医療におけるQOL評価

梅垣宏行

Geriatric Msdicine Vol. 53 ( 2 ) page： 139-142 2015.2

Increased recruitment of bone marrow-derived cells into the brain associated with altered brain cytokine profile in senescence-accelerated mice. Reviewed

Hasegawa-Ishii S, Inaba M, Li M, Shi M, Umegaki H, Ikehara S, Shimada A.

Brain Struct Funct. 2015.1

高齢者糖尿病におけるセルフケアの援助

梅垣宏行

プラクティス Vol. 32 ( 1 ) page： 53-57 2015.1

治し支える医療としての在宅医療の現状と展望在宅医療におけるQOL評価について

梅垣宏行

月刊「カレントテラピー」 page： Vol.33 No.2 2015

高齢者糖尿病患者に対するレパグリニドの安全性・有効性の検討

梅垣宏行

Diabetes Frontier Vol. 26 ( 1 ) page： 1 2015

Factors Associated with Brain Atrophy Estimated with Automatic Voxel-Based Morphometry of Structural Magnetic Resonance Images in Elderly Diabetic Patients: Impact of Albuminuria on Hippocampal Atrophy. Reviewed

Takahiko Kawamura, Toshitaka Umemura, Rui Imamine, Hiroyuki Umegaki, Naoko Kawano, Asako Mizoguchi, Mariko Kawai,Makiko Minatoguchi, Minoru Kusama, Yu Kouchi, Atsuko Watarai, Akio Kanai, Eitaro Nakashima and Nigishi Hotta

J Diabetes Metab 2014.12

高齢者糖尿病と認知症

梅垣宏行

月間糖尿病 Vol. 6 ( 11 ) page： 43-48 2014.12

Relationship between Small Cerebral White Matter Lesions and Cognitive Function in Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment Reviewed

MakinoT, Umegaki H, Suzuki Y, Yanagawa M, Nonogaki Z, Nakashima H, Kuzuya M.

Gerontol Geriatr Int Vol. 14 ( 4 ) page： 819-26 2014.10

特集／認知症の原因・予防から診断・治療まで　　1.認知症の治療―認知症患者の行動・心理症状への対応

梅垣宏行　葛谷雅文

月刊「臨床と研究」 Vol. 91 ( 7 ) page： 919-923 2014.7

認知症と糖尿病治療における課題と展望（座談会）

朝田隆、古川勝敏、梅垣宏行、田中志子、荒木厚

Vol. 52 ( 7 ) page： 803-811 2014.7

アルツハイマー型認知症患者の近時記憶障害に対するリバスチグミンの効果の検討.

梅垣宏行

新薬と臨牀 Vol. 63 ( 7 ) page： 1168-1171 2014.7

特集：神経疾患治療薬の剤形と使い分け８．アルツハイマー型認知症治療薬の剤形

梅垣宏行

学術季刊誌BRAIN MEDICAL Vol. 26 ( 2 ) page：８．アルツハイマー型認知症治療薬の剤形 2014.6

全人的医療を目指す　認知症と転倒

梅垣宏行

クリニシアン Vol. 61 ( 4-5 ) page： 487-494 2014.5

Factors associated with cognitive decline in older subjects with type 2 diabetes mellitus during a 6-year observation

Umegaki H, Kawamura T, Umemura T, Kawano N

Geriatr Gerontol Int 2014.3

認知症の身体合併症へのアプローチ：摂食障害

梅垣宏行

老年精神医学雑誌 Vol. 25 ( 増刊 ) page： 98-102 2014.3

Effect of renal impairment on cognitive function during a 3-year follow-up in elderly patients with type 2 diabetes: association with microinflammation

Journal of Diabetes Investigation Vol. 5 ( 5 ) page： 597-605 2014.2

Burden reduction of caregivers for users of care services provided by the public long-term care insurance system in Japan Reviewed

Umegaki H, Yanagawa M, Nonogaki Z, Nakashima H, Kuzuya M, Endo H

Archives of Gerontology and Geriatrics Vol. 58 ( 1 ) page： 130-133 2014

Three-graded stratification of carbohydrate restriction by level of baseline hemoglobin A1c for type 2 diabetes patients with a moderate low-carbohydrate diet

Haimoto H, Sasakabe T, Kawamura T, Umegaki H, Komeda M, Wakai K

Nutrition & Metabolism Vol. 28 ( 11 ) page： 33 2014

Type 2 diabetes as a risk factor for cognitive impairment : current insights

Umegaki H

Clinical Interventions in Aging Vol. 28 ( 9 ) page： 1011-1019 2014

Impaired glycemia and Alzheimer's disease

Umegaki H

Neurobiology of Aging Vol. 35 ( 10 ) page： e21 2014

Dynamics of bone marrow-derived cells relevant to the brain-immune cell-cell interactions under non-inflammatory conditions

Hasegawa-Ishii S, Inaba M, Ming Li, Umegaki H, Ikehara S, Shimada A.

Curr Trends Neurol Vol. 8 page： 39-52 2014

認知症の発症予防因子としての栄養

梅垣宏行

Vol. 51 ( 4 ) page： 413-417 2013.10

糖尿病と認知症

梅垣宏行

認知症の最新医療 Vol. 3 ( 4 ) page： 170-174 2013.10

高齢者糖尿病における生活指導のあり方

梅垣宏行

月刊糖尿病 Vol. 5 ( 4 ) page： 20-27 2013.4

Insulin resistance in the brain: a new therapeutic target for Alzheimer's disease Reviewed

Umegaki H

J Diabetes Investig Vol. 4 ( 2 ) page： 150-1 2013.3

Cognitive impairments and functional declines in older adults at high risk for care needs Reviewed

Umegaki H, Suzuki Y, Yanagawa M, Nonogaki Z, Nakashima H, Kuzuya M, Endo H

Geriatr Gerontol Int Vol. 13 ( 1 ) page： 77-82 2013

Cognitive dysfunction: an emerging concept of a new diabetic complication in the elderly Reviewed

Umegaki H, Hayashi T, Nomura H, Yanagawa M, Nonogaki Z, Nakshima H, Kuzuya M

Geriatr Gerontol Int Vol. 13 ( 1 ) page： 28-34 2013

Care for Alzheimer's disease Reviewed

Umegaki H, Takechi H, Dodge H

J Alzheimers Dis 2013

Dementia and diabetes: Towards the prevention of dementia through glycemic control. Reviewed

Umegaki H

Journal of Gerontology Geriatrics Research page： 00-00 2013

The response of the autonomic nervous system to the cholinesterase inhibitor, donepezil Reviewed

Umegaki H , Oyun Khookhor,

Neuroendocrinology Letters Vol. 34 ( 5 ) page： 383-387 2013

Association of Chronic Kidney Disease and Cerebral Small Vessel Disease with Cognitive Reviewed

Umemura T, Kawamura T, Umegaki H, Kawano N,Mashita S, Sakakibara T, Hotta N, Sobue G.

Dement Geriatr Cogn Disord Extra Vol. 3 page： 212-222 2013

The cholinergic stimulation of the hippocampus induced the activation of the sympathetic nervous system. Reviewed

Oyun Khookhor, Umegaki H

Neuroendocrinology Letters Vol. 34 ( 1 ) page： 58-61 2013

第54回日本老年医学会学術集会記録 <シンポジウム8：高齢者糖尿病の管理―Ｊ-EDITから得られたもの―＞５.認知症のリスクと対応

梅垣宏行

日本老年医学会雑誌 Vol. 50 ( 1 ) page： 65-67 2013

Falls in elderly at high risk of requiring care Reviewed

Umegaki H, Suzuki Y, Yanagawa M, Nonogaki Z, Endo H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 147-148 2012

Dysphagia in older adults at high risk of requiring care Reviewed

Umegaki H, Suzuki Y, Yanagawa M, Nonogaki Z, Nakashima H, Endo H

Geriatr Gerontol Int Vol. 12 ( 2 ) page： 359-361 2012

Neurodegeneration in diabetes mellitus Reviewed

Umegaki H

Adv Exp Med Biol Vol. 724 page： 258-265 2012

Long-term multiple risk factor interventions in Japanese elderly diabetic patients: the Japanese Elderly Diabetes Intervention Trial--study design, baseline characteristics and effects of intervention Reviewed

Araki A, Iimuro S, Sakurai T, Umegaki H, Iijima K, Nakano H, Oba K, Yokono K, Sone H, Yamada N, Ako J, Kozaki K, Miura H, Kashiwagi A, Kikkawa R, Yoshimura Y, Nakano T, Ohashi Y, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 7-17 2012

Non-high-density lipoprotein cholesterol: an important predictor of stroke and diabetes-related mortality in Japanese elderly diabetic patients Reviewed

Araki A, Iimuro S, Sakurai T, Umegaki H, Iijima K, Nakano H, Oba K, Yokono K, Sone H, Yamada N, Ako J, Kozaki K, Miura H, Kashiwagi A, Kikkawa R, Yoshimura Y, Nakano T, Ohashi Y, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 18-28 2012

Relations of nutritional intake to age, gender and BMI in Japanese elderly patients with type 2 diabetes - Japanese Elderly Diabetes Intervention Trial(J-EDIT) Reviewed

Yoshimura Y, Kamada C,Keiko Takahashi, Kaimoto T, Iimuro S, Ohashi Y,Araki A,Umegaki H, Sakurai T, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 29-40 2012

Optimal energy distribution of carbohydrate intake for Japanese elderly patients with type 2 diabetes: the Japanese Elderly Intervention Trial Reviewed

Kamada C, Yoshimura H, Okumura R, Takahashi K, Iimuro S, Ohashi Y, Araki A, Umegaki H, Sakurai T, Yoshimura Y, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 41-49 2012

Effects of total and green vegetable intakes on glycated hemoglobin A1c and triglycerides in elderly patients with type 2 diabetes mellitus: the Japanese Elderly Intervention Trial Reviewed

Takahashi K, Kamada C, Yoshimura H, Okumura R, Iimuro S, Ohashi Y, Araki A, Umegaki H, Sakurai T, Yoshimura Y, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 50-58 2012

Dietary pattern and mortality in Japanese elderly patients with type 2 diabetes mellitus - Does vegetable- and fish-rich diet improve mortality ?: An explanatory study Reviewed

Iimuro S, Yoshimura Y, Umegaki H, Sakurai T, Araki A, Ohashi Y, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 59-67 2012

Lower Physical Activity, but not Excessive Calorie Intake, is Associated with Metabolic Syndrome in Elderly with Type 2 Diabetes Mellitus: Japanese Elderly Diabetes Intervention Trial (J-EDIT) Reviewed

Iijima K, Iimuro S, Ohashi Y, Sakurai T, Umegaki H, Araki A, Yoshimura Y, Ouchi Y, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 68-76 2012

Lower Physical Activity is a Strong Predictor of Cardiovascular Events in Elderly Patients with Type 2 Diabetes Mellitus beyond Traditional Risk Factors: Japanese Elderly Diabetes Intervention Trial (J-EDIT) Reviewed

Iijima K, Iimuro S, Shionzaki T,Ohashi Y, Sakurai T, Umegaki H, Araki A, Ouchi Y, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 77-87 2012

Effective prevention of cardiovascular disease and diabetes-related events with atorvastatin in Japanese elderly patients with type 2 diabetes mellitus: adjusting for treatment changes using a marginal structural proportional hazards model and a rank-preserving structural failure time model Reviewed

Shinozaki T, Matsuyama Y, Iimuro S, Umegaki H, Sakurai T, Araki A, Ohashi Y, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 88-102 2012

Risk factors associated with cognitive decline in the elderly with type 2 diabetes; Baseline data analysis of Japanese elderly diabetes intervention trial (J-EDIT) Reviewed

Umegaki H, Iimuro S, Shinozaki T, Araki A, Sakurai T, Iijima K, Ohashi Y, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 103-109 2012

Risk factors associated with cognitive decline in the elderly with type 2 diabetes:Pooled logistic analysis of a 6-year observation in the Japanese elderly diabetes intervention trial (J-EDIT) Reviewed

Umegaki H, Iimuro S,Shinozaki T, Araki A, Sakurai T, Iijima K, Ohashi Y, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 110-116 2012

Risk factors for a 6-year decline in physical disability and functional limitations among elderly people with type 2 diabetes (J-EDIT) Reviewed

Sakurai T, Iimuro S, Umegaki H, Araki A, Ohashi Y, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 117-126 2012

Factors associated with progression of diabetic nephropathy in Japanese elderly patients with type 2 diabetes: Sub-analysis of the Japanese Elderly Diabetes Intervention Trial Reviewed

Araki S,Nishio Y, Araki A, Umegaki H, Sakurai T, Iimuro S, Ohashi Y, Uzu T, Maegawa H, Kashiwagi A, Ito H

Geriatr Gerontol Int Vol. 12 ( suppl 1 ) page： 127-133 2012

The effects of mild cognitive impairment on driving performance in older drivers Reviewed

Kawano N, Iwamoto K, Ebe K, Suzuki Y, Hasegawa J, Ukai K, Umegaki H, Iidaka T, Ozaki N

J Am Geriatr Soc Vol. 60 ( 7 ) page： 1379-1381 2012

Immunohistochemical demonstration of increased prostaglandin F2alpha levels in the rat hippocampus following kainic acid-induced seizures Reviewed

Takei S, Hasegawa-Ishii S, Uekawa A, Chiba Y, Umegaki H, Hosokawa M, David F Woodward, Watanabe K, Shimada AM

Neuroscience Vol. 218 page： 295-304 2012

Reduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: A 12-month intervention Reviewed

Haimoto H, Sasakabe T, Umegaki H, Wakai K

Diabetes Metab Syndr Obes Vol. 5 page： 283-291 2012

Pharmacist-based Donepezil Outpatient Consultation Service to improve medication persistence Reviewed

Watanabe N, Yamamura K, Suzuki Y, Umegaki H, Shigeno K, Matsushita R, Sai Y, Miyamoto K, Yamada K

Patient Prefer Adherence Vol. 6 page： 605-611 2012

Slower adaptation to driving simulator and simulator sickness in older adults Reviewed

Kawano N, Iwamoto K, Ebe K, Aleksic B, Noda A, Umegaki H, Kuzuya M, Iidaka T, Ozaki N

Aging Clin Exp Res Vol. 24 page： 285-289 2012

Effective prevention of cardiovascular disease and diabetes-related events with atorvastatin in Japanese elderly patients with type 2 diabetesmellitus: adjusting for treatment changes using a marginal structural proportional hazards model and a rank-preserving structual failure time model Reviewed

Shinozaki T, Matsuyama Y, Iimuro S, Umegaki H, Sakurai T, Araki A, Ohashi Y, Ito H

Gerontol Geriatr Int Vol. 12 ( suppl 1 ) page： 88-102 2012

Neurodegeneration dysfunction in old diabetes- management and treatment Reviewed

Umegaki H

Adv Exp Med Biol Vol. 771 page： 465-470 2012

特集：高齢者の運転をめぐって　4.もの忘れ外来における運転指導

梅垣宏行

Vol. 50 ( 2 ) page： 155-158 2012

特集：糖尿病患者における認知症―基礎と臨床の最新知見―Ⅲ.検査　①糖尿病患者の神経心理学的異常

梅垣宏行

月刊糖尿病 Vol. 4 ( 9 ) page： 57-64 2012

特集：アルツハイマー型認知症治療薬　ドネペジル塩酸塩が構築してきた治療エビデンス

梅垣宏行

薬局 Vol. 63 ( 2 ) page： 241-244 2012

Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse Reviewed

Hasegawa-Ishii S, Takei S, Inaba M, Umegaki H, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Shimada A.

Brain Behav Immun Vol. 25 ( 1 ) page： 83-100 2011

Association between the caregiver's burden and physical activity in community-dwelling caregivers of dementia patients Reviewed

Hirano A, Suzuki Y, Kuzuya M, Onishi J, Hasegawa J, Ban N, Umegaki H

Arch Gerontol Geriatr Vol. 52 ( 3 ) page： 295-298 2011

Factors Associated with Cognitive Declines in Elderly Diabetics Reviewed

Umegaki H, Kawamura T, Kawano N, Umemura T, Kanai A, Sano T

Dementia and Geriatric Cognitive Disorders Extra Vol. 1 page： 1-9 2011

Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice Reviewed

Hasegawa-Ishii S, Takei S, Chiba Y, Furukawa A, Umegaki H, Iguchi A, Kawamura N, Yoshikawa K, Hosokawa M, Shimada A

Neuropathology Vol. 31 ( 1 ) page： 20-28 2011

Association between improvements in insulin resistance and changes in cognitive function in elderly diabetic patients with normal cognitive function Reviewed

Yanagawa M, Umegaki H, Uno T, Oyun K, Kawano N, Maeno H, Yamanouchi K, Sato Y

Geriatr Gerontol Int Vol. 11 ( 3 ) page： 341-7 2011

Effect of a moderate low-carbohydrate diet on preferential abdominal fat loss and cardiovascular risk factors in patients with type 2 diabetes Reviewed

Sasakabe T, Haimoto H, Umegaki H, Wakai K

Diabetes Metab Syndr Obes Vol. 4 page： 167-74 2011

Strong association of insulin resistance with urinary albumin excretion in the elderly Reviewed

Umegaki H, Haimoto H, Isikawa J , Shibayama H, Watanabe Y

J Am Geriatr Soc Vol. 59 ( 7 ) page： 1361-2 2011

The association of lower hemoglobin level with depressive mood in elderly women at high risk of requiring care Reviewed

Umegaki H, Yanagawa M, Endo H

Geriatr Gerontol Int Vol. 11 ( 3 ) page： 262-6 2011

Does cerebral small vessel disease predict future decline of cognitive function in well controlled elderly patients with type 2 diabetes? Reviewed

Imamine R, Kawamura T, Umemura T, Umegaki H, Kawano N, Hotta M, Kouchi Y,Hatsuda S, Watarai A, Kanai A, Nakashima E, Sano T, Sakakibara T, Nakamura J, Hotta N

Diabetes Res Clin Pract Vol. 94 page： 91-9 2011

Endothelial and inflammatory markers in relation to progression ofischaemic cerebral small-vessel disease and cognitive impairment: a 6-year longitudinal study in patients with type 2 diabetes mellitus Reviewed

Umemura T, Kawamura T, Umegaki H, Mashita S, Kanai R, Hotta N, Sobue G

J Neurol Neursurg Pshichiatr Vol. 82 ( 11 ) page： 1186-1194 2011

Part2-疾患別：高齢者の栄養ケア　認知症

梅垣宏行

臨床栄養 Vol. 118 ( 6 ) page： 622-626 2011

栗田論文について（３）（レター）

梅垣宏行

日本老年医学会雑誌 Vol. 47 ( 3 ) page： 267 2010.5

認知症高齢者を対象とした音楽療法に関する文献的検討　介入頻度と効果の関係

山口理恵、河野直子、梅垣宏行

日本認知症ケア学会誌 Vol. 9 ( 1 ) page： 89-96 2010.4

Pathophysiology of cognitive dysfunction in older people with type 2 diabetes: vascular changes or neurodegeneration? Reviewed

Age Ageing. Vol. 39 ( 1 ) page： 8-10 2010

Effects of educational background on verbal fluency task performance in older adults with Alzheimer's disease and mild cognitive impairment Reviewed

Kawano N, Umegaki H, Suzuki Y, Yamamoto S, Mogi N, Iguchi A.

Int Psychogeriatr Vol. 22 ( 6 ) page： 995-1002 2010

Influence of regular exercise on subjective sense of burden and physical symptoms in community-dwelling caregivers of dementia patients: A randomized controlled trial Reviewed

Hirano A, Suzuki Y, Kuzuya M, Onishi J, Ban N, Umegaki H

Arch Gerontol Geriatr Vol. 53 ( 2 ) page： e158-63 2010

Age-associated increase in abdominal obesity and insulin resistance, and usefulness of AHA/NHLBI definition of metabolic syndrome for predicting cardiovascular disease in Japanese elderly with type 2 diabetes mellitus Reviewed

Sakurai T, Iimuro S, Araki A, Umegaki H, Ohashi Y, Yokono K, Ito H

Gerontology Vol. 56 ( 2 ) page： 141-9 2010

認知症高齢者を対象とした音楽療法に関する文献的検討　介入頻度と効果の関係

山口理恵、河野直子、梅垣宏行

認知症ケア学会誌 Vol. 9 ( 1 ) page： 89-95 2010

（座談会）期待される高齢者医療

梅垣宏行、細井孝之、浅井俊亘、牧　靖典、高橋　昇

現代医学 Vol. 58 ( 2 ) page： 297-324 2010

糖尿病における認知機能障害　Cognitive dysfunction in diabetic patients

梅垣宏行

老年期認知症研究会誌 Vol. 16 page： 99-100 2010

認知症治療薬に関する薬剤師の取り組みの今後

梅垣宏行

医薬ジャーナル Vol. 46 ( 5 ) page： 108-110 2010

軽度認知症をスクリーニングするための神経心理学的テスト・バッテリー

河野直子、梅垣宏行

老年精神医学雑誌 Vol. 21 ( 2 ) page： 209-214 2010

Changes in the perception of dementia in Japan Reviewed

Umegaki H, Suzuki Y, Ohnishi J, Iguchi A

Int Psychogeriatr. Vol. 21 ( 4 ) page： 793-7 2009

Responses of hypothalamo-pituitary-adrenal axis to a cholinesterase inhibitor Reviewed

Umegaki H, Yamamoto A, Suzuki Y, Iguchi A

Neuroreport Vol. 20 ( 15 ) page： 1366-70 2009

Acute metabolic responses to a high-carbohydrate meal in outpatients with type 2 diabetes treated with a low-carbohydrate diet: a crossover meal tolerance study Reviewed

Haimoto H, Sasakabe T, Umegaki H, Wakai K

Nutr Metab (Lond) Vol. 6 ( 1 ) page： 52 2009

Low HDL-cholesterol is associated with the risk of stroke in elderly diabetic individuals: Changes in the risk for atherosclerotic diseases at various ages Reviewed

Hayashi T, Kawashima S, Itoh H, Yamada N, Sone H, Watanabe H, Hattori Y, Ohrui T, Yokote K, Nomura H, Umegaki H, Iguchi A; on behalf of Japan CDM group

Diabetes Care Vol. 32 ( 7 ) page： 1221-3 2009

Effects of a low-carbohydrate diet on glycemic control in outpatients with severe type 2 diabetes Reviewed

Haimoto H, Sasakabe T, Wakai K, Umegaki H

Nutr Metab (Lond) Vol. 6 page： 21 2009

Association of higher carbohydrate intake with depressive mood in elderly diabetic women Reviewed

Umegaki H, Iimuro S, Araki A, Sakurai T, Iguchi A, Ohashi Y, Ito H

Nurtritional Neuroscience Vol. 12 ( 6 ) page： 267-71 2009

Different contribution of the lateral bed nucleus of the stria terminalis in intrahippocampal neostigmine-induced elevation of plasma glucoseand adrenocorticotropic hormone in free moving rats Reviewed

Zhu W, Cui J, Zhang R, Umegaki H

Neuroendocrinology Letter Vol. 30 ( 4 ) page： 511-4 2009

ＭＭＳＥ２４点以上の高齢者群における神経心理学的検査を用いた認知症の探索

河野直子、鈴木裕介、山本さやか、井口昭久、梅垣宏行

Dementia Japan Vol. 22 ( 3 ) page： 298-307 2009

Factors Associated with Lower Mini Mental State Examination Scores in Elderly Japanese Diabetes Mellitus Patients Reviewed

Umegaki H Satoshi Iimuro, Si Kaneko T, Araki A, Sakurai T Ohashi Y, Akihisa Iguchi A, Ito H

Neurobiol Aging Vol. 29 ( 7 ) page： 1022-6 2008

Visceral fat contribution of insulin resistance in elderly people Reviewed

Umegaki H, Haimoto H, Ishikawa J, Kario K.

J Am Geriatr Soc Vol. 56 ( 7 ) page： 1373-1375 2008

Aging of the striatum: mechanisms and interventions Invited Reviewed

Umegaki H, Roth GS, Ingram DK.

Age Vol. 30 ( 4 ) page： 251-261 2008

D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats Reviewed

Thanos PK, Michaelides M, Umegaki H, Volkow ND

Synapse Vol. 62 ( 7 ) page： 481-6 2008

Long-term effects of a loose restriction of carbohydrates diet on HbA1c levels, BMI and tapering of sulfonylureas in type 2 diabetes: a two-year follow-up study Reviewed

Haimoto H, Iwata M, Wakai K, Umegaki H

Diab Res Clin Prac Vol. 79 ( 2 ) page： 350-6 2008

Importance of Lipid Levels in Elderly Diabetic Individuals. Reviewed

Hayashi T, Kawashima S, Itoh H, Yamada N, Sone H, Watanabe H, Hattori Y, Ohrui T, Yoshizumi M, Yokote K, Kubota K, Nomura H, Umegaki H, Iguchi A; on behalf of Japan CDM group

Circ J Vol. 72 ( 2 ) page： 218-25 2008

Effect of the entorhinal cortex on diurnal ACTH and corticosterone release in rats Reviewed

Zhu W, Zhang R, Changchun H, Umegaki H

Neuroendocrinol lett Vol. 29 ( 1 ) page： 159-62 2008

Discontinuation of Donepezil for the Treatment of Alzheimer's Disease in Geriatric Practice Reviewed

Umegaki H, Itoh A, Suzuki Y, Nabeshima T

Int. Psychogeriatr. Vol. 20 ( 4 ) page： 800-6 2008

Cognitive Dysfunction in Diabetic Elderly Reviewed

Umegaki H, Kawamura T, Mogi N, Umemura T, Kanai A, Sano T

Age Ageing Vol. 37 ( 4 ) page： 458-61 2008

高齢者のメタボリックシンドローム (Invited Review)

梅垣宏行

日老医誌 Vol. 45 ( 3 ) page： 330-334 2008

Attitudes toward disclosing the diagnosis of dementia in Japan Reviewed

Umegaki H, Onishi J, Suzuki Y, Endo H, Iguchi A

Int. Psychogeriatr Vol. 19 ( 2 ) page： 253-265 2007

Which two questions of Mini-Mental State Examination (MMSE) should we start from? Reviewed

Onishi J, Suzuki Y, Umegaki H, Kawamura T, Imaizumi M, Iguchi A

Arch Gerontol Geriatr Vol. 44 ( 1 ) page： 43-8 2007

Clinical profiles of autopsy-confirmed dementia with Lewy bodies at institutionalization: Comparison with Alzheimer's disease Reviewed

Fujishiro H, Umegaki H, Suzuki Y, Isojima D, Akatsu H, Ikari H, Iguchi A, Kosaka K

Psychogeriatrics Vol. 7 ( 3 ) page： 98-103 2007

老年科における外来認知症診療の現状と展望：名古屋大学医学部附属病院老年科「外来もの忘れ検査」の利用統計から

河野直子、梅垣宏行、茂木七香、山本さやか、鈴木裕介、井口昭久

日老医誌 Vol. 44 page： 611-618 2007

ADAS単語カードを用いた遅延再生課題の軽度認知機能低下識別に対する有用性：外来もの忘れ検査利用者を対象とした検討

河野直子、梅垣宏行、鈴木裕介、山本さやか、茂木七香、井口昭久

日老医誌 Vol. 44 ( 4 ) page： 490-496 2007

認知症診療に対する態度に関する医師会会員へのアンケート調査-地域における認知症の診療体制の確立のために-

梅垣宏行、鈴木裕介、葛谷雅文、井口昭久

日老医誌 Vol. 44 page： 102-106 2007

Functional Recovery of the Striatal Cholinergic System in Aged Rats by Adenoviral Vector-mediated Gene Transfer of Dopamine D2 Receptor Reviewed

Umegaki H, Yamaguchi Y, Ishiwata, K, Roth GS, Ingram DK, Iguchi A

Vol. 127 ( 10 ) page： 813-815 2006

Behavioral, Psychological, and Physical Symptoms in Group Homes for the Older Adults with Dementia Reviewed

Onishi J, Suzuki Y, Umegaki H, Endo H, Kawamura T, Imaizumi M, Iguchi A

Int Psychogeriatr Vol. 3 page： 1-12 2006

Association between insulin resistance and cognitive function in elderly diabetic patients Reviewed

Suzuki M, Umegaki H, Uno T, Oyun, O, Mogi N, Maeno H, Yamanouchi K, Iguchi A, Sato Y

Geriatr. Gerotr, Intr Vol. 6 page： 254-9 2006

Stimulation of the Hippocampal Glutamate Receptor Systems Induces Stress-like Responses Reviewed

Umegaki H, Yamamoto A, Suzuki Y, Iguchi A

Neuroendocrinology letters Vol. 27 ( 3 ) page： 339-43 2006

Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese Elderly Diabetes Intervention Trial (J-EDIT) Reviewed

Akisaki T, Sakurai T, Takata T, Umegaki H, Araki A, Mizuno S, Tanaka S, Ohashi Y, Iguchi A, Yokono K and Ito H

Diabetes/Met Res Rev Vol. 22 ( 5 ) page： 376-84 2006

Microdialysis measurement of acetylcholine in rat hippocampus during severe insulin-induced hypoglycemia. Reviewed

Umegaki H, Yamaguchi Y, Suzuki Y, Iguchi A

Neuroendocrinol lett Vol. 27 ( 1-2 ) page： 128-32 2006

Cognitive Function in the Elderly with Diabetes Mellitus Reviewed

Umegaki H, Iguchi A

J Clin Biochem Neutr Vol. 38 ( 1 ) page： 19-24 2006

Factors associated with cognitive impairment in elderly diabetes mellitus patients Reviewed

Suzuki M, Umegaki H, Ieda S, Mogi N, Iguchi A

J Am Geriatr Soc Vol. 54 ( 3 ) page： 558-9 2006

A Comparison of Depressive Mood of older adults in a Community, Nursing Homes, and a Geriatric Hospital: Factor Analysis of Geriatric Depression Scale Reviewed

Onishi J, Suzuki Y, Umegaki H, Endo H, Kawamura T, Iguchi A

J Geriatr Psychiatry Neurol Vol. 19 ( 1 ) page： 26-31 2006

Depletion of cholinergic neurons in nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies. Invited Reviewed

Fujishiro H. Umegaki H, Isojima D, Akatsu H, Iguchi A, Kosaka K

Acta Neuropathol Vol. 11 ( 2 ) page： 109-14 2006

痴呆と未病

梅垣宏行

日老医誌 Vol. 43 ( 1 ) page： 87-88 2006

日本人高齢糖尿病の認知症、認知機能低下の危険因子—J-EDIT登録症例を用いた検討

梅垣宏行、櫻井孝、荒木厚、飯室聡、大橋靖雄、井藤英喜

糖尿病合併症 Vol. 20 ( 1 ) page： 71-74 2006

Dopamine D2 receptor has a role in memory function. Implications for dopamine-acetylcholine interaction in the ventral hippocampus Reviewed

Fujishiro H, Umegaki H, Suzuki Y, Oohara-Kurotani S, Yamaguchi Y, Iguchi A

Psychopahrmacology Vol. 182 ( 2 ) page： 253-61 2005

Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: Effects on ethanol drinking Reviewed

Thanos PK , Rivera SN, Weaver K,. Grandy DK, Rubinstein M, Umegaki H , Wang GJ , Hitzemann R ,Volkow ND

Life Sciences Vol. 77 page： 130-139 2005

The entorhinal cortex regulates blood glucose level in response to microinjection of neostigmine into the hippocampus Reviewed

Adeli-Rankouhi S, Umegaki H, Zhu W, Suzuki Y, Kurotani S, Ieda S, Iguchi A

Neuroendocrinol lett Vol. 26 page： 225-230 2005

Influence of behavioral and psychological symptoms of dementia (BPSD) and environment of care on caregivers' burden Reviewed

Onishi J, Suzuki Y, Umegaki H, Nakamura A, Endo H, Iguchi A

Arch Gerontol Geriatr Vol. 41 ( 2 ) page： 159-68 2005

名古屋市保健所における痴呆介護予防事業参加者の意識調査

藤城弘樹、梅垣宏行、鈴木裕介、中村　了、平川仁尚、井口昭久

日老医誌 Vol. 42 page： 340-345 2005

Cognitive Function in Japanese Elderly with Type 2 Diabetes Mellitus Reviewed

. Mogi N, Umegaki H, Hattori A, Maeda N, Miura H, Kuzuya M, Shimokata H, Ando F, Ito H, Iguchi A

J Diabetes Complict Vol. 18 page： 42-46 2004

DRD2 Gene Transfer Into the Nucleus Accumbens Core of the Alcohol Preferring and Nonpreferring Rats Attenuates Alcohol Drinking Reviewed

Thanos PK , Rivera SN, Weaver K,. Grandy DK, Rubinstein M, Umegaki H , Wang GJ , Hitzemann R ,Volkow ND

Alcohol Clin Exp Res Vol. 5 page： 720-728 2004

The Relationship between Functional Disability and Depressive Mood in Japanese Older Adult Inpatients Reviewed

Onishi J, Umegaki H, Suzuki Y, Uemura K, Kuzuya M, Iguchi A

J Geriatr Psychiatr Neurol Vol. 17 ( 2 ) page： 93-98 2004

The Clock Drawing Test as a Valid Screening Method for Mild Cognitive Impairment Reviewed

Yamamoto S, Mogi N, Umegaki H, Suzuki Y, Ando F, Shimokata H, Iguchi A

Dementi Geriatr Cogn Vol. 18 ( 2 ) page： 172-179 2004

Smell identification test as an indicator for cognitive impairment in Alzheimer's disease. Reviewed

Suzuki Y, Yamamoto S, Umegaki H, Onishi J, Mogi N, Fujishiro H, Iguchi A

Int J Geriatr Psychiatry Vol. 19 ( 8 ) page： 727-33 2004

「高齢者医療の現状と展望」　最近のトピックス　諸外国における高齢者医療の現状

遠藤英俊, 大島伸一, 三浦久幸, 大西丈二, 梅垣宏行, 鈴木裕介, 井口昭久

日本内科学会雑誌 Vol. 93 ( 12 ) page： 2599-2602 2004

Longitudinal follow-up study of adenoviral vector-mediated gene transfer of dopamine D2 receptors in the striatum in young, middle-aged, and aged rats: a positron emission tomography study

Umegaki H, Ishiwata K, Ogawa O, Ingram DK, Roth GS, Oda K, Kurotani S, Kawamura K, Wang WF, Ikari H, Senda M, Iguchi A

Neuroscience Vol. 121 page： 479-486 2003

Atrovastatin, 3-Hydroxy 3- Methylglutaryl Coenzyme A Reductase Inhibitor, reduces bone resorption in the elderly. Reviewed

Kuzuya M, Suzuki Y, Asai T, Koike T, Kanda S, Nakamura A, Satake S, Umegaki H, Iguchi A

JAGS Vol. 51 page： 1677-1678 2003

Different glial reaction to hippocampal stab wounds in young adult and aged rats Reviewed

Zhu W, Umegaki H, Shinkai T, Kurotani S, Suzuki Y, Endo H, Iguchi A

J Gerontol A Biol Sci Med Sci Vol. 58 ( 2 ) page： B117-22 2003

Involvement of the entorhinal cortex in the stress response to immobilization, but not to insulin-induced hypoglycemia Reviewed

Umegaki H, Zhu W, Nakamura A, Suziki Y, Takada M, Endo H, Iguchi A

J Neuroendocrinol Vol. 15 page： 237-241 2003

Identification of factors associated with long hospital stay in Japanese geriatric ward Reviewed

Umegaki H, Ando F, Shimokata H, Yamamoto S, Nakamura A, Endo H, Kuzuya M, Iguchi A.

Geriatr Gerintol Int Vol. 3 ( 2 ) page： 120-7 2003

The Age-Associated Changes of Dopamine-Acetylcholine Interaction in the Striatum. Reviewed

Kurotani S, Umegaki H, Ishiwata K, Suzuki Y, Iguchi A

Exp. Gerontol Vol. 38/39 page： 1009-13 2003

In vivo assessment of adenoviral vector-mediated gene expression of dopamine D2 receptors in the rat striatum by positron emission tomography

Umegaki H, Ishiwata K, Ogawa O., Ingram DK, Roth GS, Yoshimura J, Oda K, Matsui-Hirai H, Ikari H, Iguchi A, Senda M

Synapse Vol. 43 page： 195-200 2002

Plasma Insulin and Glucose Levels in Elderly Female Subjects with Alzheimer's Disease Reviewed

Umegaki H, Ushida C, Ikari H, Ogawa O, Nakamura A, Suzuki Y, Endo H, Akatsu H, Yamamoto T, Iguchi A

Geriatr Gerontol Int Vol. 2 page： 75-9 2002

Positron emission tomography and ex vivo and in vitro autradiography studies on dopamin D2-like receptor degeneration in quinolinic acid- lesioned rat striatum. Reviewed

Ishiwata K, Ogi N, Hayakawa N, Umegaki H, Nagaoka T, Oda K, Toyama H, Endo K, Tanaka A, Senda M

Nuclear Medicine and biology Vol. 29 page： 307-16 2002

Involvement of dopamine D2 receptor in complex maze and acetylcholine release in ventral hippocampus of rats Reviewed

Umegaki H, Munoz J, Meyer RC, Spangler EL, Yoshimura J, Ikari H, Iguchi A, Ingram DK

Neuroscience Vol. 103 ( 1 ) page： 27-33 2001

Assessment of brain atrophy in elderly subjects with diabetes mellitus by computed tomography Reviewed

Ushida C, Umegaki H, Hattori A, Mogi N, Aoki S, Iguchi A

Geriatr Gerontol Int Vol. 1 page： 33-7 2001

The elevation of plasma adrenocorticotrophic hormone and expression of c-Fos in hypothalamic paraventricular nucleus by microinjection of neostigmine into the hippocampus in rats: comparison with acute stress responses. Reviewed

Zhu W, Umegaki H, Yoshimura J, Tamaya N, Suzuki Y, Miura H, Iguchi A

Brain Res Vol. 892 ( 2 ) page： 391-5 2001

Overexpression of dopamine D2 receptors reduces alcohol self-administration Reviewed

Thanos PK, Volkow ND, Freimuth P, Umegaki H, Ikari H, Roth GS, Ingram DK, Hitzemann R

J Neurochem Vol. 78 ( 5 ) page： 1094-103 2001

Involvement of the bed nucleus of the stria terminalis in hippocampal cholinergic system-mediated activation of the hypothalamo-pituitary-adrenocortical axis in rats Reviewed

Zhu W, Umegaki H, Suzuki Y, Miura H, Iguchi A

Brain Res Vol. 916 page： 101-6 2001

Dietary restriction of choline reduces hippocampal acetylcholine release in rats: in vivo microdialysis study. Reviewed

Nakamura A, Suzuki Y, Umegaki H, Ikari H, Tajima T, Endo H, Iguchi A

Brain Res Bull Vol. 56 ( 6 ) page： 593-7 2001

The metabolism of plasma glucose and catecholamines in Alzheimer's disease Reviewed

Umegaki H, Tamaya N, Shinkai T, Iguchi A

Exp. Gerontol Vol. 35 ( 9-10 ) page： 1373-82 2000

Low plasma epinephrine in elderly female subjects of dementia of Alzheimer's type. Reviewed

Umegaki H, Ikari H, Nakahata H, Yoshimura J, Endo H, Yamamoto T, Iguchi A

Brain Res Vol. 858 page： 67-70 2000

In vivo imaging of adenovirus-mediated over-expression of dopamine D2 receptors in rat striatum by positron emission tomography Reviewed

Ogawa O, Umegaki H, Ishiwata K, Asai Y, Ikari H, Oda K, Toyama H, Ingram DK, Roth G.S, Iguchi A, Senda M

Neuroreport Vol. 11 ( 4 ) page： 743-8 2000

Development of an adenoviral vector for intracerebral delivery of the dopamine D2 receptor. Reviewed

Ingram DK, Umegaki H, Ikari H, Roth G.S

Mech Ageing Dev Vol. 116 ( 2-3 ) page： 77-93 2000

Plasma cortisol levels in elderly female subjects with Alzheimer's disease: a cross-sectional and longitudinal study. Reviewed

Umegki H, Ikari H, Nakahata H, Endo H, Suzuki Y, Ogawa O, Nakamura A, Yamamoto T, Iguchi A

Brain Res Vol. 881 ( 2 ) page： 241-3 2000

Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in beta-amyloid protein-stimulated J774 cells Reviewed

Ogawa O, Umegaki H, Sumi D, Hayashi T, Nakamura A, Thakur NK, Yoshimura J, Endo H, Iguchi A

Eur. J. Pharmacol Vol. 408 ( 2 ) page： 137-41 2000

Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway Reviewed

Luo Y, Umegaki H, Wang X, Abe R, Roth GS

J Biol Chem Vol. 273 ( 6 ) page： 3756-64 1998

Application of Gene Therapy to Treat Age-Related Loss of Dopamine D2 Receptor Reviewed

Ingram DK, Ikari H, Umegaki H, Chernak JM, Roth GS

Exp. Gerontol Vol. 33 ( 7-8 ) page： 793-804 1998

Intrastriatal injection of dopamine results in DNA damage and apoptosis in rats Reviewed

Hattori A, Luo Y, Umegaki H, Munoz J, Roth GS

Neuroreport Vol. 9 ( 11 ) page： 2569-72 1998

Rotational behavior produced by adenovirus-mediated gene transfer of dopamine D2 receptor into rat striatum Reviewed

Umegaki H, Chernak JM, Ikari H, Roth GS, Ingram DK

Neuroreport Vol. 8 ( 16 ) page： 3553-8 1997

Possible involvement of catalase in the protective effect of interleukin-6 against 6-hydroxydopamine toxicity in PC12 cells Reviewed

Yamada K, Umegaki H, Maezawa I, Iguchi A, Kameyama T, Nabeshima T

Brain Res. Bull Vol. 43 ( 6 ) page： 573-7 1997

Nabeshima T. Protective effect of interleukin-6 against the death of PC12 cells caused by serum deprivation or by the addition of a calcium ionophore Reviewed

Umegaki H, Yamada K, Naito M, Kameyama T, Iguchi A

Biochem Pharmacol Vol. 52 ( 6 ) page： 911-6 1996

Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia Reviewed

Yamada K, Kono K, Umegaki H, Yamada K, Iguchi A, Fukatsu T, Nakashima N, Nishiwaki H, Shimada Y, Sugita Y, Yamamoto T, Hasegawa T, Nabeshima T

Neurosci. Lett Vol. 186 ( 2-3 ) page： 219-221 1995

Protective effects of probucol against glutamate-induced cytotoxicity in neuronal cell line PC12 Reviewed

Naito M, Umegaki H, Iguchi A

Neurosci. Lett Vol. 186 ( 2-3 ) page： 211-3 1995

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