Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl₃ model

Jin, XY; Yue, XL; Huang, Z; Meng, XK; Xu, SN; Wu, YN; Wan, Y; Inoue, A; Narisawa, M; Hu, LN; Shi, GP; Umegaki, H; Murohara, T; Lei, YN; Kuzuya, M; Cheng, XW

CELLULAR AND MOLECULAR LIFE SCIENCES   Vol. 81 ( 1 ) page： 205   2024.12

Multidomain Intervention Trial for Preventing Cognitive Decline among Older Adults with Type 2 Diabetes: J-MIND-Diabetes

Sugimoto, T; Araki, A; Fujita, H; Fujita, K; Honda, K; Inagaki, N; Ishida, T; Kato, J; Kishi, M; Kishino, Y; Kobayashi, K; Kouyama, K; Kuroda, Y; Kuwahata, S; Matsumoto, N; Murakami, T; Noma, H; Ogino, J; Ogura, M; Ohishi, M; Shimada, H; Sugimoto, K; Takenaka, T; Tamura, Y; Tokuda, H; Uchida, K; Umegaki, H; Sakurai, T

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE   Vol. 11 ( 6 ) page： 1604 - 1614   2024.12

Management of older adults with diabetes mellitus: Perspective from geriatric medicine

Umegaki, H

JOURNAL OF DIABETES INVESTIGATION   Vol. 15 ( 10 ) page： 1347 - 1354   2024.10

Frailty Index Based on Common Laboratory Tests for Patients Starting Home-Based Medical Care

Nakashima, H; Watanabe, K; Komiya, H; Fujisawa, C; Yamada, Y; Sakai, T; Tajima, T; Umegaki, H

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION   Vol. 25 ( 9 ) page： 105114   2024.9

Dual Sensory Impairment Predicts an Increased Risk of Postdischarge Falls in Older Patients

Yamada, Y; Nakashima, H; Nagae, M; Watanabe, K; Fujisawa, C; Komiya, H; Tajima, T; Sakai, T; Satake, S; Takeya, Y; Umeda-Kameyama, Y; Umegaki, H

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION   Vol. 25 ( 9 ) page： 105123   2024.9

Objective physical function declines in the absence of subjective physical complaints among patients with amnestic mild cognitive impairments and mild alzheimer's disease

Fujisawa, C; Umegaki, H; Sugimoto, T; Nakashima, H; Komiya, H; Watanabe, K; Nagae, M; Yamada, Y; Tajima, T; Sakai, T; Sakurai, T

EUROPEAN GERIATRIC MEDICINE   Vol. 15 ( 5 ) page： 1503 - 1508   2024.6

Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial

Sakurai, T; Sugimoto, T; Akatsu, H; Doi, T; Fujiwara, Y; Hirakawa, A; Kinoshita, F; Kuzuya, M; Lee, SY; Matsumoto, N; Matsuo, K; Michikawa, M; Nakamura, A; Ogawa, S; Otsuka, R; Sato, K; Shimada, H; Suzuki, H; Suzuki, H; Takechi, H; Takeda, S; Uchida, K; Umegaki, H; Wakayama, S; Arai, H

ALZHEIMERS & DEMENTIA   Vol. 20 ( 6 ) page： 3918 - 3930   2024.6

Association of marital relationship with quality of life among older adults with mild cognitive impairment and mild dementia

Fujisawa, C; Nakashima, H; Komiya, H; Watanabe, K; Yamada, Y; Tajima, T; Umegaki, H

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 24 ( 6 ) page： 646 - 647   2024.6

Hospital-associated complications in frail older adults.

Umegaki H

Nagoya journal of medical science   Vol. 86 ( 2 ) page： 181 - 188   2024.5

Association between intrinsic capacity and oral health in older patients in a frailty clinic

Miyahara, S; Maeda, K; Kawamura, K; Matsui, Y; Satake, S; Arai, H; Umegaki, H

EUROPEAN GERIATRIC MEDICINE   Vol. 15 ( 4 ) page： 1119 - 1127   2024.3

Relationship between cognitive function and phase angle measured with a bioelectrical impedance system

Yamada, Y; Watanabe, K; Fujisawa, C; Komiya, H; Nakashima, H; Tajima, T; Umegaki, H

EUROPEAN GERIATRIC MEDICINE   Vol. 15 ( 1 ) page： 201 - 208   2024.2

Muscle ultrasound and its application to point-of-care ultrasonography: a narrative review

Nagae, M; Umegaki, H; Yoshiko, A; Fujita, K

ANNALS OF MEDICINE   Vol. 55 ( 1 ) page： 190 - 197   2023.12

Comparing prevalence and types of potentially inappropriate medications among patient groups in a post-acute and secondary care hospital

Nakashima, H; Ando, H; Umegaki, H

SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page： 14543   2023.9

Cathepsin S activity controls chronic stress-induced muscle atrophy and dysfunction in mice

Wan, Y; Piao, LM; Xu, SN; Meng, XK; Huang, Z; Inoue, A; Wang, HL; Yue, XL; Jin, XY; Nan, YS; Shi, GP; Murohara, T; Umegaki, H; Kuzuya, M; Cheng, XW

CELLULAR AND MOLECULAR LIFE SCIENCES   Vol. 80 ( 9 ) page： 254   2023.9

Combined use of the Clinical Frailty Scale and laboratory tests in acutely hospitalized older patients

Nakashima, H; Nagae, M; Komiya, H; Fujisawa, C; Watanabe, K; Yamada, Y; Tajima, T; Miyahara, S; Sakai, T; Umegaki, H

AGING CLINICAL AND EXPERIMENTAL RESEARCH   Vol. 35 ( 9 ) page： 1927 - 1935   2023.9

Intrinsic capacity in acutely hospitalized older adults

Nagae, M; Umegaki, H; Komiya, H; Nakashima, H; Fujisawa, C; Watanabe, K; Yamada, Y; Miyahara, S

EXPERIMENTAL GERONTOLOGY   Vol. 179   page： 112247   2023.8

COVID-19 pandemic increased the risk of prescribing potentially inappropriate medications to older adults

Suzuki, Y; Shiraishi, N; Komiya, H; Sakakibara, M; Akishita, M; Umegaki, H

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 23 ( 7 ) page： 579 - 581   2023.7

Dehydration and hospital-associated disability in acute hospitalized older adults

Nagae, M; Umegaki, H; Komiya, H; Fujisawa, C; Watanabe, K; Yamada, Y; Miyahara, S

EUROPEAN GERIATRIC MEDICINE   Vol. 14 ( 1 ) page： 113 - 121   2023.2

Early-onset Alzheimer Disease Associated With Neuromyelitis Optica Spectrum Disorder

Fujisawa, C; Saji, N; Takeda, A; Kato, T; Nakamura, A; Sakurai, K; Asanomi, Y; Ozaki, K; Takada, K; Umegaki, H; Kuzuya, M; Sakurai, T

ALZHEIMER DISEASE & ASSOCIATED DISORDERS   Vol. 37 ( 1 ) page： 85 - 87   2023.1

Clinical significance of geriatric conditions in acute hospitalization

Umegaki, H; Nagae, M; Komiya, H; Watanabe, K; Yamada, Y; Sakai, T; Tajima, T

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 23 ( 1 ) page： 50 - 53   2023.1

Relationship Between Non-Cognitive Intrinsic Capacity and Activities of Daily Living According to Alzheimer's Disease Stage

Fujisawa, C; Umegaki, H; Sugimoto, T; Nakashima, H; Nagae, M; Komiya, H; Watanabe, K; Yamada, Y; Sakurai, T

JOURNAL OF ALZHEIMERS DISEASE   Vol. 96 ( 3 ) page： 1115 - 1127   2023

Young bone marrow transplantation prevents aging-related muscle atrophy in a senescence-accelerated mouse prone 10 model

Inoue, A; Piao, LM; Yue, XL; Huang, Z; Hu, LN; Wu, HX; Meng, XK; Xu, WH; Yu, CL; Sasaki, T; Itakura, K; Umegaki, H; Kuzuya, M; Cheng, XW

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE   Vol. 13 ( 6 ) page： 3078 - 3090   2022.12

Association between changes in frailty during hospitalization in older adults and 3-month mortality after discharge

Umegaki, H; Nagae, M; Komiya, H; Watanabe, K; Yamada, Y; Sakai, T

EUROPEAN GERIATRIC MEDICINE   Vol. 13 ( 6 ) page： 1403 - 1406   2022.12

Selection of chemotherapy for older patients with pancreatic cancer based on geriatric assessment

Maeda, O; Matsuoka, A; Yanagawa, M; Muroyama, Y; Watanabe, K; Liang, Y; Ishikawa, T; Ohno, E; Kawashima, H; Umegaki, H; Kuzuya, M; Ando, Y

JOURNAL OF GERIATRIC ONCOLOGY   Vol. 13 ( 8 ) page： 1260 - 1263   2022.11

Japan Geriatrics Society "Statement for the use of telemedicine in geriatric care: Telemedicine as a complement to in-person medical practice": Geriatric Medical Practice Committee consensus statement

Nomura, K; Ebihara, S; Ikebata, Y; Umegaki, H; Ooi, K; Ogawa, S; Katsuya, T; Kobayashi, Y; Sakurai, T; Miyao, M; Yamaguchi, K; Akishita, M

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 22 ( 11 ) page： 913 - 916   2022.11

Relationship of creatinine cystatin C ratio with muscle mass and grip strength in memory clinic outpatients

Yamada, Y; Umegaki, H; Sugimoto, T; Nagae, M; Komiya, H; Watanabe, K; Sakurai, T

EXPERIMENTAL GERONTOLOGY   Vol. 168   page： 111935   2022.10

Muscle changes on muscle ultrasound and adverse outcomes in acute hospitalized older adults

Nagae, M; Umegaki, H; Yoshiko, A; Fujita, K; Komiya, H; Watanabe, K; Yamada, Y; Sakai, T; Kuzuya, M

NUTRITION   Vol. 102   page： 111698   2022.10

Muscle Evaluation and Hospital-Associated Disability in Acute Hospitalized Older Adults

Nagae, M; Umegaki, H; Yoshiko, A; Fujita, K; Komiya, H; Watanabe, K; Yamada, Y; Sakai, T

JOURNAL OF NUTRITION HEALTH & AGING   Vol. 26 ( 7 ) page： 681 - 687   2022.7

Association between gait speed and errors on the Clock Drawing Test in older adults with mild cognitive impairment

Umegaki, H; Suzuki, Y; Komiya, H; Watanabe, K; Nagae, M; Yamada, Y; Kuzuya, M

SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page： 9929   2022.6

Older adults with a higher frailty index tend to have electrolyte imbalances

Fujisawa, C; Umegaki, H; Sugimoto, T; Huang, CH; Fujisawa, H; Sugimura, Y; Kuzuya, M; Toba, K; Sakurai, T

EXPERIMENTAL GERONTOLOGY   Vol. 163   page： 111778   2022.6

In Response to Study Results Concerning the Impact of Antidepressants in Older Adults With Major Depressive Disorder Relating to Frailty

Sakai, T; Shiroshita, A; Momosaki, R; Umegaki, H

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES   Vol. 77 ( 5 ) page： 1063 - 1064   2022.5

Mantle cell lymphoma with aseptic meningitis mimicking hydrocephalus on brain imaging

Samizo, S; Furukawa, K; Umegaki, H

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 2 ) page： 470 - 476   2022.5

Clinical characteristics of older adults with hypertension and unrecognized cognitive impairment

Yamamoto, K; Akasaka, H; Yasunobe, Y; Shimizu, A; Nomoto, K; Nagai, K; Umegaki, H; Akasaki, Y; Kojima, T; Kozaki, K; Kuzuya, M; Ohishi, M; Akishita, M; Takami, Y; Rakugi, H

HYPERTENSION RESEARCH   Vol. 45 ( 4 ) page： 612 - 619   2022.4

Physical Activity and Neurodegeneration in Older Adults: Comment on: "Associations Between Physical Activity, Blood-Based Biomarkers of Neurodegeneration and Cognition in Healthy Older Adults: The MAPT Study"

Umegaki, H

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES   Vol. 77 ( 1 ) page： E34 - E35   2022.1

Impact of Sarcopenia on Decline in Quality of Life in Older People with Mild Cognitive Impairment

Umegaki, H; Suzuki, Y; Komiya, H; Watanabe, K; Nagae, M; Yamada, Y

JOURNAL OF ALZHEIMERS DISEASE   Vol. 88 ( 1 ) page： 23 - 27   2022

Short- and long-term effects of different exercise programs on the gait performance of older adults with subjective cognitive decline: A randomized controlled trial

Fujita, K; Umegaki, H; Makino, T; Uemura, K; Hayashi, T; Inoue, A; Uno, C; Kitada, T; Huang, CH; Shimada, H; Kuzuya, M

EXPERIMENTAL GERONTOLOGY   Vol. 156   page： 111590   2021.12

Active Life for Brain Health: A Narrative Review of the Mechanism Underlying the Protective Effects of Physical Activity on the Brain

Umegaki, H; Sakurai, T; Arai, H

FRONTIERS IN AGING NEUROSCIENCE   Vol. 13   page： 761674   2021.11

Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice

Goto, H; Inoue, A; Piao, LM; Hu, LN; Huang, Z; Meng, XK; Suzuki, Y; Umegaki, H; Kuzuya, M; Cheng, XW

STEM CELLS INTERNATIONAL   Vol. 2021   page： 9202990   2021.11

Relationships between overactive bladder and cerebral white matter hyperintensity in outpatients at a memory clinic

Komiya, H; Umegaki, H; Ogama, N; Sakurai, T; Kuzuya, M

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 21 ( 11 ) page： 996 - 1002   2021.11

Association of dehydration with development of dementia among non-demented geriatric outpatients

Nagae, M; Umegaki, H; Suzuki, Y; Komiya, H; Watanabe, K; Yamada, Y; Kuzuya, M

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 21 ( 10 ) page： 963 - 964   2021.10

The Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT): The Study Protocol for an 18-Month, Multicenter, Randomized, Controlled Trial

Sugimoto, T; Sakurai, T; Akatsu, H; Doi, T; Fujiwara, Y; Hirakawa, A; Kinoshita, F; Kuzuya, M; Lee, S; Matsuo, K; Michikawa, M; Ogawa, S; Otsuka, R; Sato, K; Shimada, H; Suzuki, H; Suzuki, H; Takechi, H; Takeda, S; Umegaki, H; Wakayama, S; Arai, H

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE   Vol. 8 ( 4 ) page： 465 - 476   2021.9

Association of verbal fluency test with progression to dementia in non-demented older adults. Invited Reviewed

Umegaki H, Suzuki Y.

  Vol. 21 ( 9 ) page： 868 - 869   2021.9

Echo intensity is more useful in predicting hospital-associated complications than conventional sarcopenia-related parameters in acute hospitalized older patients

Nagae, M; Umegaki, H; Yoshiko, A; Fujita, K; Komiya, H; Watanabe, K; Yamada, Y; Kuzuya, M; Leeuwenburgh, C

EXPERIMENTAL GERONTOLOGY   Vol. 150   page： 111397   2021.7

The Multi-Domain Intervention Trial in Older Adults With Diabetes Mellitus for Prevention of Dementia in Japan: Study Protocol for a Multi-Center, Randomized, 18-Month Controlled Trial

Sugimoto, T; Araki, A; Fujita, H; Honda, K; Inagaki, N; Ishida, T; Kato, J; Kishi, M; Kobayashi, K; Kouyama, K; Noma, H; Ohishi, M; Satoh-Asahara, N; Shimada, H; Sugimoto, K; Suzuki, S; Takeya, Y; Tamura, Y; Tokuda, H; Umegaki, H; Watada, H; Yamada, Y; Sakurai, T

FRONTIERS IN AGING NEUROSCIENCE   Vol. 13   page： 680341   2021.7

Chronic Effects of a Static Stretching Program on Hamstring Strength

Nakao, S; Ikezoe, T; Nakamura, M; Umegaki, H; Fujita, K; Umehara, J; Kobayashi, T; Ibuki, S; Ichihashi, N

JOURNAL OF STRENGTH AND CONDITIONING RESEARCH   Vol. 35 ( 7 ) page： 1924 - 1929   2021.7

Functional categories based on cognition and activities of daily living predict all-cause mortality in older adults with diabetes mellitus: The Japanese Elderly Diabetes Intervention Trial

Omura, T; Tamura, Y; Sakurai, T; Umegaki, H; Iimuro, S; Ohashi, Y; Ito, H; Araki, A

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 21 ( 6 ) page： 512 - 518   2021.6

Effect of Various Exercises on Intrinsic Capacity in Older Adults With Subjective Cognitive Concerns.

Huang CH, Umegaki H, Makino T, Uemura K, Hayashi T, Kitada T, Inoue A, Shimada H, Kuzuya M

Journal of the American Medical Directors Association   Vol. 22 ( 4 ) page： 780 - +   2021.4

Determinants and impact of physical impairment in patient-reported outcomes among older patients with type 2 diabetes mellitus in Japan.

Araki A, Umegaki H, Sakurai T, Mizuno Y, Miyao M, Imori M, Suzuki S, Cambron-Mellott MJ, Yokote K, Onuma T, Yokono K

Current medical research and opinion   Vol. 37 ( 3 ) page： 393 - 402   2021.3

Association of fear of falling with cognitive function and physical activity in older community-dwelling adults

Umegaki Hiroyuki, Uemura Kazuki, Makino Taeko, Hayashi Takahiro, Cheng Xian Wu, Kuzuya Masafumi

EUROPEAN GERIATRIC MEDICINE   Vol. 12 ( 1 ) page： 99 - 106   2021.2

Mild hyponatremia is associated with low skeletal muscle mass, physical function impairment, and depressive mood in the elderly

Fujisawa, C; Umegaki, H; Sugimoto, T; Samizo, S; Huang, CH; Fujisawa, H; Sugimura, Y; Kuzuya, M; Toba, K; Sakurai, T

BMC GERIATRICS   Vol. 21 ( 1 ) page： 15   2021.1

Mental Health Status of the Older Adults in Japan During the COVID-19 Pandemic

Fujita, K; Inoue, A; Kuzuya, M; Uno, C; Huang, CH; Umegaki, H; Onishi, J

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION   Vol. 22 ( 1 ) page： 220 - 221   2021.1

Frequencies and Neuropsychological Characteristics of Errors in the Clock Drawing Test

Umegaki, H; Suzuki, Y; Komiya, H; Watanabe, K; Yamada, Y; Nagae, M; Kuzuya, M

JOURNAL OF ALZHEIMERS DISEASE   Vol. 82 ( 3 ) page： 1291 - 1300   2021

Effects of Aerobic, Resistance, or Combined Exercise Training Among Older Adults with Subjective Memory Complaints: A Randomized Controlled Trial

Makino, T; Umegaki, H; Ando, M; Cheng, XW; Ishida, K; Akima, H; Oshida, Y; Yoshida, Y; Uemura, K; Shimada, H; Kuzuya, M

JOURNAL OF ALZHEIMERS DISEASE   Vol. 82 ( 2 ) page： 701 - 717   2021

Cross-Sectional Examination of Homocysteine Levels with Sarcopenia and Its Components in Memory Clinic Outpatients

Yamada, Y; Umegaki, H; Kinoshita, F; Huang, CH; Sugimoto, T; Fujisawa, C; Komiya, H; Watanabe, K; Nagae, M; Kuzuya, M; Sakurai, T

JOURNAL OF ALZHEIMERS DISEASE   Vol. 82 ( 3 ) page： 975 - 984   2021

Associations Between Polypharmacy and Gait Speed According to Cognitive Impairment Status: Cross-Sectional Study in a Japanese Memory Clinic

Watanabe, K; Umegaki, H; Sugimoto, T; Fujisawa, C; Komiya, H; Nagae, M; Yamada, Y; Kuzuya, M; Sakurai, T; Stirland, L

JOURNAL OF ALZHEIMERS DISEASE   Vol. 82 ( 3 ) page： 1115 - 1122   2021

FRAILTY IN A FRAILTY PREVENTION PROGRAM PARTICIPANTS DURING COVID-19 PANDEMIC: A CROSS-SECTIONAL JAPANESE STUDY

Kanamori, T; Suzuki, M; Naito, T; Inagaki, K; Umegaki, H

INNOVATION IN AGING   Vol. 5   page： 816 - 816   2021

HOme-based Longitudinal Investigation of the multidiSciplinary Team Integrated Care (HOLISTIC): protocol of a prospective nationwide cohort study.

Liao JY, Chen PJ, Wu YL, Cheng CH, Yu SJ, Huang CH, Li CM, Wang YW, Zhang KP, Liu IT, Umegaki H, Hamano J, Mori M, Petersen I, Sampson EL, Hsiung CA

BMC geriatrics   Vol. 20 ( 1 ) page： 511   2020.12

Effect of various exercises on frailty among older adults with subjective cognitive concerns: a randomised controlled trial.

Huang CH, Umegaki H, Makino T, Uemura K, Hayashi T, Kitada T, Inoue A, Shimada H, Kuzuya M

Age and ageing   Vol. 49 ( 6 ) page： 1011 - 1019   2020.11

Chronic Dehydration in Nursing Home Residents.

Nagae M, Umegaki H, Onishi J, Huang CH, Yamada Y, Watanabe K, Komiya H, Kuzuya M

Nutrients   Vol. 12 ( 11 )   2020.11

Association of the Qualitative Clock Drawing Test with Progression to Dementia in Non-Demented Older Adults.

Umegaki H, Suzuki Y, Yamada Y, Komiya H, Watanabe K, Nagae M, Kuzuya M

Journal of clinical medicine   Vol. 9 ( 9 ) page： 2850   2020.9

Association of polypharmacy with decline in quality of life in mild cognitive impairment and mild dementia

Umegaki Hiroyuki

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 20 ( 9 ) page： 840 - 842   2020.9

Association Between Sarcopenia and Quality of Life in Patients with Early Dementia and Mild Cognitive Impairment.

  Vol. 76 ( 1 ) page： 435-442   2020.5

A Study on the Relationship between Cognitive Performance, Hearing Impairment, and Frailty in Older Adults.

Bonfiglio V, Umegaki H, Kuzuya M

Dementia and geriatric cognitive disorders   Vol. 49 ( 2 ) page： 156-162   2020.4

Combined Impact of Physical Frailty and Social Isolation on Rate of Falls in Older Adults

Hayashi T., Umegaki Hiroyuki, Makino T., Huang C. H., Inoue A., Shimada H., Kuzuya M.

JOURNAL OF NUTRITION HEALTH & AGING   Vol. 24 ( 3 ) page： 312 - 318   2020.3

Falls in community-dwelling prefrail older adults

Umegaki Hiroyuki, Makino Taeko, Uemura Kazuki, Shimada Hiroyuki, Cheng Xian Wu, Dodge Hiroko, Kuzuya Masafumi

HEALTH & SOCIAL CARE IN THE COMMUNITY   Vol. 28 ( 1 ) page： 110 - 115   2020.1

Assessing the association between optimal energy intake and all-cause mortality in older patients with diabetes mellitus using the Japanese Elderly Diabetes Intervention Trial

Omura Takuya, Tamura Yoshiaki, Yamaoka Takuya, Yoshimura Yukio, Sakurai Takashi, Umegaki Hiroyuki, Kamada Chiemi, Iimuro Satoshi, Ohashi Yasuo, Ito Hideki, Araki Atsushi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 20 ( 1 ) page： 59 - 65   2020.1

[Malignant lymphoma with IgG4-related disease arising in a very elderly man].

Nagae M, Onishi J, Umegaki H, Kuzuya M

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   Vol. 57 ( 3 ) page： 321-326   2020

Cathepsin S-Mediated Negative Regulation of Wnt5a/SC35 Activation Contributes to Ischemia-Induced Neovascularization in Aged Mice

Xu Wenhu, Yu Chenglin, Piao Limei, Inoue Aiko, Wang Hailong, Meng Xiangkun, Li Xiang, Cui Lan, Umegaki Hiroyuki, Shi Guo-Ping, Murohara Toyoaki, Kuzuya Masafumi, Cheng Xian Wu

CIRCULATION JOURNAL   Vol. 83 ( 12 ) page： 2537 - +   2019.12

Plasma orexin-A levels in patients with delirium.

Nakashima H, Umegaki H, Yanagawa M, Komiya H, Watanabe K, Kuzuya M

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society   Vol. 19 ( 6 ) page： 628-630   2019.11

Quality of life in cognitively impaired older adults

Bonfiglio Viviana, Umegaki Hiroyuki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 19 ( 10 ) page： 999 - 1005   2019.10

Association between dysphagia risk and unplanned hospitalization in older patients receiving home medical care

Watanabe Kazuhisa, Umegaki Hiroyuki, Huang Chi-Hsien, Arakawa Martins Beatriz, Asai Atsushi, Kanda Shigeru, Nomura Hideki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 19 ( 10 ) page： 977 - 981   2019.10

Higher and Lower Muscle Echo Intensity in Elderly Individuals Is Distinguished by Muscle Size, Physical Performance and Daily Physical Activity.

Yoshiko Akito, Natsume Yukie, Makino Taeko, Hayashi Takahiro, Umegaki Hiroyuki, Yoshida Yasuko, Cheng Xian Wu, Kuzuya Masafumi, Ishida Koji, Koike Teruhiko, Oshida Yoshiharu, Akima Hiroshi

ULTRASOUND IN MEDICINE AND BIOLOGY   Vol. 45 ( 9 ) page： 2372 - 2380   2019.9

Plasma orexin-A-like immunoreactivity levels and renal function in patients in a geriatric ward

Nakashima Hirotaka, Umegaki Hiroyuki, Yanagawa Madoka, Komiya Hitoshi, Watanabe Kazuhisa, Kuzuya Masafumi

PEPTIDES   Vol. 118   page： 170092   2019.8

Relationship between blood coagulability and sense of burden among caregivers of patients with dementia

Hirano Akemi, Suzuki Yusuke, Umegaki Hiroyuki, Hayashi Toshio, Ina Koichiro, Onishi Joji, Hasegawa Jun, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 19 ( 8 ) page： 804 - 808   2019.8

Polypharmacy and gait speed in individuals with mild cognitive impairment

Umegaki Hiroyuki, Yanagawa Madoka, Komiya Hitoshi, Matsubara Masaki, Fujisawa Chisato, Suzuki Yusuke, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 19 ( 8 ) page： 730 - 735   2019.8

Cathepsin S Deficiency Mitigated Chronic Stress-Related Neointimal Hyperplasia in Mice

Wang Hailong, Meng Xiangkun, Piao Limei, Inoue Aiko, Xu Wenhu, Yu Chenglin, Nakamura Kae, Hu Lina, Sasaki Takeshi, Wu Hongxian, Unno Kazumasa, Umegaki Hiroyuki, Murohara Toyoaki, Shi Guo-Ping, Kuzuya Masafumi, Cheng Xian Wu

JOURNAL OF THE AMERICAN HEART ASSOCIATION   Vol. 8 ( 14 ) page： e011994   2019.7

Response to the comments on "Sarcopenia and depressive mood in older adults"

Hayashi Takahiro, Umegaki Hiroyuki, Makino Taeko, Cheng Xian W., Shimada Hiroyuki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 19 ( 7 ) page： 690 - 691   2019.7

Association between sarcopenia and depressive mood in urban-dwelling older adults: A cross-sectional study

Hayashi Takahiro, Umegaki Hiroyuki, Makino Taeko, Cheng Xian W., Shimada Hiroyuki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 19 ( 6 ) page： 508 - 512   2019.6

Prevalence and risk factors of constipation and pollakisuria among older home-care patients

Komiya Hitoshi, Umegaki Hiroyuki, Asai Atsushi, Kanda Shigeru, Maeda Keiko, Nomura Hideki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 19 ( 4 ) page： 277 - 281   2019.4

[Diabetes Mellitus and Dementia].

Umegaki H

Brain and nerve = Shinkei kenkyu no shinpo   Vol. 71 ( 4 ) page： 409-414   2019.4

Association of Glucose Fluctuations with Sarcopenia in Older Adults with Type 2 Diabetes Mellitus

Ogama Noriko, Sakurai Takashi, Kawashima Shuji, Tanikawa Takahisa, Tokuda Haruhiko, Satake Shosuke, Miura Hisayuki, Shimizu Atsuya, Kokubo Manabu, Niida Shumpei, Toba Kenji, Umegaki Hiroyuki, Kuzuya Masafumi

JOURNAL OF CLINICAL MEDICINE   Vol. 8 ( 3 ) page： 319   2019.3

Potentially inappropriate medications according to STOPP-J criteria and risks of hospitalization and mortality in elderly patients receiving home-based medical services

Huang Chi-Hsien, Umegaki Hiroyuki, Watanabe Yuuki, Kamitani Hiroko, Asai Atushi, Kanda Shigeru, Nomura Hideki, Kuzuya Masafumi

PLOS ONE   Vol. 14 ( 2 ) page： e0211947   2019.2

Complaint of poor night sleep is correlated with physical function impairment in mild Alzheimer's disease patients

Fujisawa Chisato, Umegaki Hiroyuki, Nakashima Hirotaka, Kuzuya Masafumi, Toba Kenji, Sakurai Takashi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 19 ( 2 ) page： 171 - 172   2019.2

Change in quality of life and potentially associated factors in patients receiving home-based primary care: a prospective cohort study

Huang Chi-Hsien, Umegaki Hiroyuki, Kamitani Hiroko, Asai Atushi, Kanda Shigeru, Maeda Keiko, Nomura Hideki, Kuzuya Masafumi

BMC GERIATRICS   Vol. 19 ( 1 ) page： 21   2019.1

Potentially Inappropriate Medications and Polypharmacy: A Study of Older People with Mild Cognitive Impairment and Mild Dementia.

Bonfiglio V, Umegaki H, Kuzuya M

  Vol. 71 ( 3 ) page： 889-897   2019

Potentially Inappropriate Medications and Polypharmacy: A Study of Older People with Mild Cognitive Impairment and Mild Dementia

Bonfiglio Viviana, Umegaki Hiroyuki, Kuzuya Masafumi

JOURNAL OF ALZHEIMERS DISEASE   Vol. 71 ( 3 ) page： 889 - 897   2019

Postprandial Hyperglycemia Is Associated With White Matter Hyperintensity and Brain Atrophy in Older Patients With Type 2 Diabetes Mellitus

Ogama Noriko, Sakurai Takashi, Kawashima Shuji, Tanikawa Takahisa, Tokuda Haruhiko, Satake Shosuke, Miura Hisayuki, Shimizu Atsuya, Kokubo Manabu, Niida Shumpei, Toba Kenji, Umegaki Hiroyuki, Kuzuya Masafumi

FRONTIERS IN AGING NEUROSCIENCE   Vol. 10   page： 273   2018.9

Diabetes-related cognitive dysfunction: Hyperglycemia in the early stage might be a key? Reviewed

Umegaki H

J Diabetes Investig.   Vol. 9 ( 5 ) page： 1019-1021   2018.9

Maximum gait speed is associated with a wide range of cognitive functions in Japanese older adults with a Clinical Dementia Rating of 0.5. Reviewed

Umegaki H, Makino T, Yanagawa M, Nakashima H, Kuzuya M, Sakurai T, Toba K.

Geriatr Gerontol Int.   Vol. 18 ( 9 ) page： 1323-1329   2018.9

Association between insulin resistance and objective measurement of physical activity in community-dwelling older adults without diabetes mellitus

Umegaki Hiroyuki, Makino Taeko, Uemura Kazuki, Shimada Hiroyuki, Hayashi Takahiro, Cheng Xian Wu, Kuzuya Masafumi

DIABETES RESEARCH AND CLINICAL PRACTICE   Vol. 143   page： 267 - 274   2018.9

Maximum gait speed is associated with a wide range of cognitive functions in Japanese older adults with a Clinical Dementia Rating of 0.5

Umegaki Hiroyuki, Makino Taeko, Yanagawa Madoka, Nakashima Hirotaka, Kuzuya Masafumi, Sakurai Takashi, Toba Kenji

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 18 ( 9 ) page： 1323 - 1329   2018.9

Diabetes-related cognitive dysfunction: Hyperglycemia in the early stage might be a key?

Umegaki Hiroyuki

JOURNAL OF DIABETES INVESTIGATION   Vol. 9 ( 5 ) page： 1019 - 1021   2018.9

Correlation between regional cerebral blood flow and body composition in cognitively healthy elderly women: a SPECT study. Reviewed

Fujisawa C, Umegaki H, Kato T, Nakashima H, Kuzuya M, Ito K, Toba K, Sakurai T

Geriatr Gerontol Int   Vol. 18 ( 8 ) page： 1303-1304   2018.8

Correlation between regional cerebral blood flow and body composition in healthy older women: A single-photon emission computed tomography study

Fujisawa Chisato, Umegaki Hiroyuki, Kato Takashi, Nakashima Hirotaka, Kuzuya Masafumi, Ito Kengo, Toba Kenji, Sakurai Takashi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 18 ( 8 ) page： 1303 - 1304   2018.8

Association between insulin resistance and objective measurement of physical activity in community-dwelling older adults without diabetes mellitus. Reviewed

Umegaki H, Makino T, Uemura K, Shimada H, Hayashi T, Cheng X W, Kuzuya M.

Diabetes Res Clin Pract   Vol. 143   page： 267   2018.7

基礎・臨床研究の最新動向　Ⅴ.高齢者へのアプローチ　高齢者病態の特徴

梅垣宏行

日本臨床   Vol. 76 ( 5 ) page： 299～304   2018.6

Frontal white matter hyperintensity is associated with verbal aggressiveness in elderly women with alzheimer disease and amnestic nils cognitive impairment. Reviewed

Ogama N, Sakurai T, Saji N, Nakai T, Niida S, Toba K, Umegaki H, Kuzuya M

Dement Geriatr Cogn Disord Extra   Vol. 8 ( 1 ) page： 138-150   2018.4

Cilostazol for the prevention of pneumonia: a systematic review. Reviewed

Nakashima H, Watanabe K, Umegaki H, Suzuki Y, Kuzuya M.

Pneumonia   Vol. 10   page： 3   2018.4

Cognitive Dysfunction in Urban-Community Dwelling Prefrail Older Subjects. Reviewed

Umegaki H, Makino T, Shimada H, Hayashi T, Wu Cheng X, Kuzuya M.

J Nutr Health Aging   Vol. 22 ( 4 ) page： 549-554   2018.4

高齢者医療ハンドブック-高齢者医療におけるダイバーシティへの対応】(第II章)高齢者と老年症候群 やせ(解説/特集)

梅垣宏行

㈱南江堂   Vol. 121 ( 4 ) page： 645-648   2018.4

Cognitive Dysfunction in Urban-Community Dwelling Prefrail Older Subjects

Umegaki H., Makino T., Shimada H., Hayashi T., Cheng X. Wu, Kuzuya M.

JOURNAL OF NUTRITION HEALTH & AGING   Vol. 22 ( 4 ) page： 549 - 554   2018.4

病気とくすり2018　基礎と実践Expert’s Guide 精神・中枢神経の病気とくすり　認知症

梅垣宏行、渡邉雄貴、山田清文

薬局   Vol. 69 ( 4 ) page： 738-746   2018.3

Objectively measured physical activity and cognitive function in urban-dwelling older subjects Reviewed

Umegaki H, Makino T, Uemura K, Shimada H, Cheng X W, Kuzuya M.

Geriatr Gerontol Int   Vol. 18 ( 6 ) page： 922-928   2018.2

Cathepsin K activity controls cardiotoxin-induced skeletal muscle repair in mice. Reviewed

Ogasawara S, Cheng XW, Inoue A, Hu L, Piao L, Yu C, Goto H, Xu W, Zhao G, Lei Y, Yang G, Kimura K, Umegaki H, Shi GP, Kuzuya M.

J Cachexia Sarcopenia Muscle   Vol. 9 ( 1 ) page： 160–175   2018.2

高齢者の総合機能評価

梅垣宏行,葛谷雅文

救急医学   Vol. 42 ( 2 ) page： 204～209   2018.2

Cathepsin K activity controls cardiotoxin-induced skeletal muscle repair in mice

Ogasawara Shinyu, Cheng Xian Wu, Inoue Aiko, Hu Lina, Piao Limei, Yu Chenglin, Goto Hiroki, Xu Wenhu, Zhao Guangxian, Lei Yanna, Yang Guang, Kimura Kaoru, Umegaki Hiroyuki, Shi Guo-Ping, Kuzuya Masafumi

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE   Vol. 9 ( 1 ) page： 160 - 175   2018.2

Factors associated with polypharmacy in elderly home-care patients

Komiya H, Umegaki H, Atsushi A, Kanda S, Maeda K, Shimojima T, Nomura H, Kuzuya M

Geriatr Gerontol Int.   Vol. 18 ( 1 ) page： 33-41   2018.1

在宅医療を受ける高齢者のQOL (quality of life) 評価票における本人と介護者による代理評価の回答の一致性の検討

紙谷博子、梅垣宏行、岡本和士、神田茂、浅井真嗣、下島卓弥、野村秀樹、服部文子、木股貴哉、鈴木裕介、大島浩子、葛谷雅文

日本老年医学会雑誌   Vol. 55 ( 1 ) page： 98-105   2018.1

脳波データを用いたMMSEスコアの推定に関する検討

三輪晃暉、高倉健太郎、吉川大弘、古橋　武、寶珠山　稔、牧野多恵子、柳川まどか、鈴木裕介、梅垣宏行、葛谷雅文

信学技報   Vol. 117 ( 417 ) page： 信学技報   2018.1

Effects of a Thermal Agent and Physical Activity on Muscle Tendon Stiffness, as Well as the Effects Combined With Static Stretching

Fujita Kosuke, Nakamura Masatoshi, Umegaki Hiroki, Kobayashi Takuya, Nishishita Satoru, Tanaka Hiroki, Ibuki Satoko, Ichihashi Noriaki

JOURNAL OF SPORT REHABILITATION   Vol. 27 ( 1 ) page： 66 - 72   2018.1

Frontal White Matter Hyperintensity Is Associated with Verbal Aggressiveness in Elderly Women with Alzheimer Disease and Amnestic Mild Cognitive Impairment

Ogama Noriko, Sakurai Takashi, Saji Naoki, Nakai Toshiharu, Niida Shumpei, Toba Kenji, Umegaki Hiroyuki, Kuzuya Masafumi

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA   Vol. 8 ( 1 ) page： 138 - 150   2018.1

Factors associated with polypharmacy in elderly home-care patients

Komiya Hitoshi, Umegaki Hiroyuki, Asai Atsushi, Kanda Shigeru, Maeda Keiko, Shimojima Takuya, Nomura Hideki, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 18 ( 1 ) page： 33 - 41   2018.1

Study on Estimation of MMSE Score by Using the Latency of P300 and Alpha Wave

Miwa Koki, Yoshikawa Tomohiro, Furuhashi Takeshi, Hoshiyama Minoru, Makino Taeko, Yanagawa Madoka, Suzuki Yusuke, Umegaki Hiroyuki, Kuzuya Masafumi

2018 JOINT 10TH INTERNATIONAL CONFERENCE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS (SCIS) AND 19TH INTERNATIONAL SYMPOSIUM ON ADVANCED INTELLIGENT SYSTEMS (ISIS)     page： 195 - 199   2018

Cilostazol for the prevention of pneumonia: a systematic review

Nakashima Hirotaka, Watanabe Kazuhisa, Umegaki Hiroyuki, Suzuki Yusuke, Kuzuya Masafumi

PNEUMONIA   Vol. 10   page： 3   2018

[Agreement in the responses to self-reported and proxy-reported versions of QOL-HC: a new quality-of-life scale for patients receiving home-based medical care].

Kamitani H, Umegaki H, Okamoto K, Kanda S, Asai A, Shimojima T, Nomura H, Hattori A, Kimata T, Suzuki Y, Ohshima H, Kuzuya M

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   Vol. 55 ( 1 ) page： 98-105   2018

高齢糖尿病患者における血糖コントロールの現状

服部孝二、梅垣宏行、小宮　仁、渡邊一久、葛谷雅文

日老医誌   Vol. 54   page： 531-536   2017.12

Authors' reply to the letter by Esra et al

Umegaki H, Nonogaki Z, Makino T, Suzuki Y, Kuzuya M

Geriatr Gerontol Int.   Vol. 17 ( 11 ) page： 2284-2285   2017.11

高齢者とインスリン分泌促進薬

梅垣宏行

糖尿病の最新治療   Vol. 9 ( 1 ) page： 32-36   2017.11

Ⅲ．高齢者糖尿病の管理・治療上の留意点 ３．薬物療法 （2）経口血糖降下薬使用時の留意点

梅垣宏行

高齢者糖尿病   Vol. 75 ( 11 ) page： 1689   2017.11

Authors' reply to the letter by Esra et al

Umegaki Hiroyuki, Nonogaki Zen, Makino Taeko, Suzuki Yusuke, Kuzuya Masafumi

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 17 ( 11 ) page： 2284 - 2285   2017.11

（質疑応答）塩酸ドネペジルの認知症症状の進行抑制効果とは？

梅垣宏行

日本医事新報     page： 59   2017.10

Factors associated with unexpected admissions and mortality among low-functioning older patients receiving home medical care.

Umegaki H, Asai A, Kanda S, Maeda K, Shimojima T, Nomura H, Kuzuya M.

Geriatr Gerontol Int   Vol. 17 ( 10 ) page： 1623-1627   2017.10

認知機能の評価と対応

梅垣宏行　

月刊糖尿病   Vol. 9 ( 9 ) page： 28-33   2017.9

Low intakes of carotene, vitamin B2, pantothenate, and calcium predict cognitive decline among elderly patients with diabetes mellitus: the Japanese Elderly Diabetes Intervention Trial Research Group.

Araki A, Yoshimura Y, Sakurai T, Umegaki H, Kamada C, Iimuro S, Ohashi Y, Ito H; Japanese Elderly Diabetes Intervention Trial Research Group.

Geriatr Gerontol Int.   Vol. 17 ( 8 ) page： 1168 - 1175   2017.8

高齢者糖尿病のインスリンの使用法

梅垣宏行

Geriatric Med.   Vol. 55 ( 8 ) page： 905-908   2017.8

高齢者糖尿病の血糖管理目標について

梅垣宏行

Medical Practice   Vol. 34 ( 6 ) page： 1044   2017.6

高齢者糖尿病患者の食事・運動療法がわからない！？

梅垣宏行、葛谷雅文

Diabetes　Strategy   Vol. 7 ( 5 ) page： 75-79   2017.5

Physical Function Differences Between the Stages From Normal Cognition to Moderate Alzheimer Disease.

Fujisawa C, Umegaki H, Okamoto K, Nakashima H, Kuzuya M, Toba K, Sakurai T.

J Am Med Dir Assoc.   Vol. 18 ( 4 ) page： 368.e9-368.e15   2017.4

Physical Function Differences Between the Stages From Normal Cognition to Moderate Alzheimer Disease

Fujisawa Chisato, Umegaki Hiroyuki, Okamoto Kazushi, Nakashima Hirotaka, Kuzuya Masafumi, Toba Kenji, Sakurai Takashi

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION   Vol. 18 ( 4 ) page： 368.e9 - 368.e15   2017.4

The associations among insulin resistance, hyperglycemia, physical performance, diabetes mellitus, and cognitive function in relatively healthy older adults with subtle cognitive dysfunction.

Umegaki H, Makino T, Uemura K, Shimada H, Hyashi T, Cheng XY, Kuzuya M.

Front aging neurosci.     page： doi: 10.3389/fnagi.2017.00072.   2017.3

The Associations among Insulin Resistance, Hyperglycemia, Physical Performance, Diabetes Mellitus, and Cognitive Function in Relatively Healthy Older Adults with Subtle Cognitive Dysfunction

Umegaki Hiroyuki, Makino Taeko, Uemura Kazuki, Shimada Hiroyuki, Hayashi Takahiro, Cheng Xian Wu, Kuzuya Masafumi

FRONTIERS IN AGING NEUROSCIENCE   Vol. 9   page： 72   2017.3

Impact of frontal white matter hyperintensity on instrumental activities of daily living in elderly women with Alzheimer disease and amnestic mild cognitive impairment.

Ogama N, Sakurai T, Nakai T, Niida S, Saji N, Toba K, Umegaki H, Kuzuya M.

PLoS One.   Vol. 12 ( 3 ) page： e0172484   2017.3

Impact of frontal white matter hyperintensity on instrumental activities of daily living in elderly women with Alzheimer disease and amnestic mild cognitive impairment

Ogama Noriko, Sakurai Takashi, Nakai Toshiharu, Niida Shumpei, Saji Naoki, Toba Kenji, Umegaki Hiroyuki, Kuzuya Masafumi

PLOS ONE   Vol. 12 ( 3 ) page： e0172484   2017.3

Association of blood pressure and cognitive decline in older adults with diabetes mellitus during a 9-year observational study.

Umegaki H, Kawamura T, Umemura T, Kawano N

Geriatr Gerontol Int.   Vol. 17 ( 3 ) page： 514 - 515   2017.3

Development and validation of a new quality of life scale for patients receiving home-based medical care: The Observational Study of Nagoya Elderly with Home Medical Care.

Kamitani H, Umegaki H, Okamoto K, Kanda S, Asai A, Maeda K, Nomura H, Shimojima T, Suzuki Y, Ohshima H, Kuzuya M.

Geriatr Gerontol Int   Vol. 17 ( 3 ) page： 440-448   2017.3

精神・神経系の病気とくすり　中枢系疾患認知症（解説／特集）

梅垣宏行、渡邉雄貴、山田清文

薬局   Vol. 68 ( 4 ) page： 740-748   2017.3

Association of blood pressure and cognitive decline in older adults with diabetes mellitus during a 9-year observational study

Umegaki Hiroyuki, Kawamura Takahiko, Umemura Toshitaka, Kawano Naoko

GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 17 ( 3 ) page： 514-515   2017.3

Randomized,Double-blind Placebo-controlled Multicenter Trial of Yokukansan for Neuropsychiatric Symptoms in Alzheimer's Disease.

Furukawa K, Tomita N, Uematsu D, Okahara K, Shimada H, Ikeda M, Matsui T, Kozaki K, Fujii M, Ogawa T, Umegaki H, Urakami K, Nomura H, Kobayashi N, Nakanishi A, Washimi Y, Yonezawa H, Takahashi S, Kubota M, Wakutani Y, Ito D, Sasaki T, Matsubara E, Une K, Ishiki A, Yahagi Y, Shoji M, Sato H, Terayama Y, Kuzuya M, Araki N, Kodama M, Yamaguchi T, Arai H.

Geriatr Gerontol Int   Vol. 17 ( 2 ) page： 211-218   2017.2

The relationship between cardiac autonomic function and cognitive function in Alzheimer's disease.

Nonogaki Z, Umegaki H, Makino T, Suzuk Y, Kuzuya M.

Geriatr Gerontol Int   Vol. 17 ( 1 ) page： 92-98   2017.1

糖尿病とサルコペニア・フレイルの関連

梅垣宏行

Geriat.Med.   Vol. 55 ( 1 ) page： 41-43   2017.1

高齢者における糖尿病治療　Update

梅垣宏行、葛谷雅文

最新医学   Vol. 72 ( 1 ) page： 79～83   2017.1

「差分解説欄」高齢者糖尿病の血糖コントロール目標

梅垣宏行

日本医事新報     page： 53   2017.1

[State of glycemic control in elderly diabetic patients].

Hattori K, Umegaki H, Komiya H, Watanabe K, Kuzuya M

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics   Vol. 54 ( 4 ) page： 531-536   2017

Neuropsychological differences in Alzheimer's disease patients with or without type 2 diabetes mellitus.

Yanagawa M, Umegaki H, Makino T, Nakashima H, Kuzuya M.

Geriatr Gerontol Int   Vol. 16 ( 11 ) page： 1232-1235   2016.11

糖尿病患者におけるフレイル・認知症

梅垣宏行

Medical Practice   Vol. 33 ( 8 ) page： 1245-1248   2016.8

Low intakes of carotene, vitamin B2, pantothenate, and calcium predict cognitive decline among elderly patients with diabetes mellitus: the Japanese Elderly Diabetes Intervention Trial Research Group.

Araki A, Yoshimura Y, Sakurai T, Umegaki H, Kamada C, Iimuro S, Ohashi Y, Ito H; Japanese Elderly Diabetes Intervention Trial Research Group.

Geriatr Gerrontol Int     2016.7

Neuroanatomical correlates of error types on the Clock Drawing Test in Alzheimer's disease patients.

Nakashima H, Umegaki H, Makino T, Kato K, Abe S, Suzuki Y, Kuzuya M.

Geriatr Gerontol Int   Vol. 16 ( 7 ) page： 777-784   2016.7

Therapeutic Potential of Antidiabetic Medications in the Treatment of Cognitive Dysfunction and Dementia.

Umegaki H.

Drugs Aging.   Vol. 33 ( 6 ) page： 399-409   2016.6

【超高齢社会における適正薬物療法の特質～ガイドラインの今日的役割と薬剤師の責務～】 高齢者糖尿病の薬物療法

梅垣宏行

医療ジャーナル   Vol. 52 ( 6 ) page： 1455-1458   2016.6

Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain-immune interface.

Hasegawa-Ishii S, Inaba M, Umegaki H, Unnno K, Wakabayashi K, Shimada A.

Sci Rep.     2016.5

認知症の栄養と食事療法.

梅垣宏行

Geriatric Medicine (老年医学)   Vol. 54 ( 5 ) page： 225-228   2016.5

新時代の臨床糖尿病学（下）―より良い血糖管理をめざして―XIV．ライフステージ別糖尿病3.高齢者糖尿病(4)高齢者糖尿病の検査・診断.

梅垣宏行

日本臨床   Vol. 74 ( 増刊　2 ) page： 547   2016.4

疾病予防・重症化予防栄養・運動による認知症の発症・重症化予防

梅垣宏行

臨床栄養　別冊セレクト11 　健康寿命延伸をめざす栄養戦略     page： 94-98   2016.4

認知症を合併した糖尿病の治療 糖尿病治療の現在と未来.

梅垣宏行

診断と治療   Vol. 104 ( 増刊 ) page： 198-202   2016.3

Sarcopeina and frailty in older patients with diabetes mellitus.

Umegaki H

    2016.3

Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain-immune interface.

Hasegawa-Ishii S, Inaba M, Umegaki H, Unno K, Wakabayashi K, Shimada A

Scientific Reports   Vol. 5 ( 6 ) page： 25457   2016.3

精神・神経系の病気とくすり　中枢系疾患　認知症（解説／特集）

梅垣宏行、渡邉雄貴、山田清文

薬局　   Vol. 67 ( 4 ) page： 624-632   2016.3

Factors associated with changes in brain atrophy during a 3-year observation in elderly diabetic patients; Effect of renal impairment on hippocampal atrophy.

Kawamura T, Umemura T, Umegaki H, Imamine R, Kawano N, Mase H, Mizoguchi A, Minatoguchi M, Kusama M, Kouchi Y, Watarai A, Kanai A, Nakashima E, Hotta N.

Dement Geriatr Cogn Disord Extra   Vol. 6 ( 1 ) page： 55-67   2016.2

認知症患者の生命予後

梅垣宏行、葛谷雅文

日本老年精神医学会誌   Vol. 27 ( 2 ) page： 146-151   2016.2

Development and validation of a new quality of life scale for patients receiving home-based medical care: The Observational Study of Nagoya Elderly with Home Medical Care.

Kamitani H, Umegaki H, Okamoto K, Kanda S, Asai A, Maeda K, Nomura H, Shimojima T, Suzuki Y, Ohshima H, Kuzuya M

Geriatr Gerontol Int.     2016.1

在宅医療における入院などに関連する因子の検討

梅垣宏行

日本老年医学会雑誌   Vol. 53 ( 1 ) page： 32-37   2016.1

特集　患者さんと医療者の不安を解決　認知症なんでもQ＆A ・認知症を予防するために何をすればよいですか。・認知症になったらもう治療法はないのですか。

梅垣宏行

糖尿病ケア   Vol. 13 ( 1 ) page： 25-28   2016.1

Risk factors for the discontinuation of home medical care among low-functioning older patients

Umegaki H, Asai A, Kanda S, Maeda K, Shimojima T, Nomura H, Kuzuya M.

The Journal of Nutrition, Health and Aging, First online   Vol. 20 ( 4 ) page： 453-457   2016

認知症患者の生命予後.

梅垣宏行、葛谷雅文

日本老年精神医学会誌     page： 146-151   2016

Effects of Mild Cognitive Impairment on the Development of Fear of Falling in Older Adults: A Prospective Cohort Study.

Uemura K, Shimada H, Makizako H, Doi T, Tsutsumimoto K, Lee S, Umegaki H, Kuzuya M, Suzuki T

J Am Med Dir Assoc     2015.12

Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease.

Furukawa K, Tomita N, Uematsu D, Okahara K, Shimada H, Ikeda M, Matsui T, Kozaki K, Fujii M, Ogawa T, Umegaki H, Urakami K, Nomura H, Kobayashi N, Nakanishi A, Washimi Y, Yonezawa H, Takahashi S, Kubota M, Wakutani Y, Ito D, Sasaki T, Matsubara E, Une K, Ishiki A, Yahagi Y, Shoji M, Sato H, Terayama Y, Kuzuya M, Araki N, Kodama M, Yamaguchi T, Arai H.

Geriatr Gerontol Int.     2015.12

The relationship between cardiac autonomic function and cognitive function in Alzheimer’s disease

Nonogaki Z, Umegaki H, Makino T, Suzuk Yi, Kuzuya M

    2015.12

Sarcopenia and diabetes: Hyperglycemia is a risk factor for age-associated muscle mass and functional reduction.

Umegaki H

J Diabetes Investig   Vol. 6 ( 6 ) page： 623-4   2015.11

糖尿病患者の神経心理学的異常

梅垣宏行

Progress in Medicine   Vol. 35 ( 9 ) page： 57-62   2015.9

The prevalence of homebound individuals in the elderly population: a survey in a city area in Japan Reviewed

Umegaki H, Yanagawa M, Nakashima H, Makino T, Kuzuya M.

Nagoya Journal of Medical Science   Vol. 77 ( 3 ) page： 439-446   2015.8

Effects of leisure activities at home on perceived care burden and the endocrine system of caregivers of dementia patients: a randomized controlled study.

Hirano A, Umegaki H, Suzuki Y, Hayashi T, Kuzuya M

Int Psychogeriatr   Vol. 20   page： 1-8   2015.8

Neuroanatomical correlates of error types on the Clock Drawing Test in Alzheimer's disease patients. Reviewed

Nakashima H, Umegaki H, Makino T, Kato K, Abe S, Suzuki Y, Kuzuya M.

Geriatr Gerontol Int     2015.7

ロコモティブシンドロームのすべて　認知症とロコモ

梅垣宏行

医師会雑誌   Vol. 144 ( 特別号（1） ) page： 289-291   2015.6

高齢者糖尿病の食事・運動療法の進歩

梅垣宏行

Geriatric Medicine(老年医学)   Vol. 53 ( 5 ) page： 457-460   2015.6

高齢者糖尿病の食事・運動療法の進歩.

梅垣宏行

Geriatric Medicine(老年医学)   Vol. 53 ( 5 ) page： 457-460   2015.6

Q2 メモリークリニックとは？Q4 認知症の診断過程と鑑別は？

梅垣宏行

Medical Rehabilitation （2015年5月増刊号）   Vol. 183 ( 増刊 ) page： 7-10,16-19   2015.5

Association of decrease in carbohydrate intake with reduction in abdominal fat during 3-month moderate low-carbohydrate diet among non-obese Japanese patients with type 2 diabetes.

Sasakabe T, Haimoto H, Umegaki H, Wakai K.

Geriatr Gerontol Int   Vol. 64 ( 5 ) page： 618-25   2015.5

Dementia: Type 2 diabetes has a slow and insidious effect on cognition. Reviewed

Umegaki H.

Nat Rev Neurol.   Vol. 11 ( 3 ) page： 127-8   2015.3

Association of decrease in carbohydrate intake with reduction in abdominal fat during 3-month moderate low-carbohydrate diet among non-obese Japanese patients with type 2 diabetes.

Sasakabe T,Haimoto H, Umegaki H, Wakai K.

Metabolism.   Vol. 64 ( 5 ) page： 618-25   2015.3

特集　在宅医療の新しい展開／在宅医療におけるQOL評価

梅垣宏行

Geriatric Msdicine   Vol. 53 ( 2 ) page： 139-142   2015.2

Increased recruitment of bone marrow-derived cells into the brain associated with altered brain cytokine profile in senescence-accelerated mice. Reviewed

Hasegawa-Ishii S, Inaba M, Li M, Shi M, Umegaki H, Ikehara S, Shimada A.

Brain Struct Funct.     2015.1

高齢者糖尿病におけるセルフケアの援助

梅垣宏行

プラクティス   Vol. 32 ( 1 ) page： 53-57   2015.1

治し支える医療としての在宅医療の現状と展望 在宅医療におけるQOL評価について

梅垣宏行

月刊「カレントテラピー」     page： Vol.33 No.2   2015

高齢者糖尿病患者に対するレパグリニドの安全性・有効性の検討

梅垣宏行

Diabetes Frontier   Vol. 26 ( 1 ) page： 1   2015

Factors Associated with Brain Atrophy Estimated with Automatic Voxel-Based Morphometry of Structural Magnetic Resonance Images in Elderly Diabetic Patients: Impact of Albuminuria on Hippocampal Atrophy. Reviewed

Takahiko Kawamura, Toshitaka Umemura, Rui Imamine, Hiroyuki Umegaki, Naoko Kawano, Asako Mizoguchi, Mariko Kawai,Makiko Minatoguchi, Minoru Kusama, Yu Kouchi, Atsuko Watarai, Akio Kanai, Eitaro Nakashima and Nigishi Hotta

J Diabetes Metab     2014.12

高齢者糖尿病と認知症

梅垣宏行

月間糖尿病   Vol. 6 ( 11 ) page： 43-48   2014.12

Relationship between Small Cerebral White Matter Lesions and Cognitive Function in Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment Reviewed

MakinoT, Umegaki H, Suzuki Y, Yanagawa M, Nonogaki Z, Nakashima H, Kuzuya M.

Gerontol Geriatr Int   Vol. 14 ( 4 ) page： 819-26   2014.10

特集／認知症の原因・予防から診断・治療まで　　1.認知症の治療―認知症患者の行動・心理症状への対応

梅垣宏行　葛谷雅文

月刊「臨床と研究」   Vol. 91 ( 7 ) page： 919-923   2014.7

認知症と糖尿病治療における課題と展望（座談会）

朝田隆、古川勝敏、梅垣宏行、田中志子、荒木厚

  Vol. 52 ( 7 ) page： 803-811   2014.7

アルツハイマー型認知症患者の近時記憶障害に対するリバスチグミンの効果の検討.

梅垣宏行

新薬と臨牀   Vol. 63 ( 7 ) page： 1168-1171   2014.7

特集：神経疾患治療薬の剤形と使い分け ８．アルツハイマー型認知症治療薬の剤形

梅垣宏行

学術季刊誌BRAIN MEDICAL   Vol. 26 ( 2 ) page： ８．アルツハイマー型認知症治療薬の剤形   2014.6

全人的医療を目指す　認知症と転倒

梅垣宏行

クリニシアン   Vol. 61 ( 4-5 ) page： 487-494   2014.5

Factors associated with cognitive decline in older subjects with type 2 diabetes mellitus during a 6-year observation

Umegaki H, Kawamura T, Umemura T, Kawano N

Geriatr Gerontol Int     2014.3

認知症の身体合併症へのアプローチ：摂食障害

梅垣宏行

老年精神医学雑誌   Vol. 25 ( 増刊 ) page： 98-102   2014.3

Effect of renal impairment on cognitive function during a 3-year follow-up in elderly patients with type 2 diabetes: association with microinflammation

Journal of Diabetes Investigation   Vol. 5 ( 5 ) page： 597-605   2014.2

Burden reduction of caregivers for users of care services provided by the public long-term care insurance system in Japan Reviewed

Umegaki H, Yanagawa M, Nonogaki Z, Nakashima H, Kuzuya M, Endo H

Archives of Gerontology and Geriatrics   Vol. 58 ( 1 ) page： 130-133   2014

Impaired glycemia and Alzheimer's disease

Umegaki H

Neurobiology of Aging   Vol. 35 ( 10 ) page： e21   2014

Three-graded stratification of carbohydrate restriction by level of baseline hemoglobin A1c for type 2 diabetes patients with a moderate low-carbohydrate diet

Haimoto H, Sasakabe T, Kawamura T, Umegaki H, Komeda M, Wakai K

Nutrition & Metabolism   Vol. 28 ( 11 ) page： 33   2014

Type 2 diabetes as a risk factor for cognitive impairment : current insights

Umegaki H

Clinical Interventions in Aging   Vol. 28 ( 9 ) page： 1011-1019   2014

Dynamics of bone marrow-derived cells relevant to the brain-immune cell-cell interactions under non-inflammatory conditions

Hasegawa-Ishii S, Inaba M, Ming Li, Umegaki H, Ikehara S, Shimada A.

Curr Trends Neurol   Vol. 8   page： 39-52   2014

認知症の発症予防因子としての栄養

梅垣宏行

  Vol. 51 ( 4 ) page： 413-417   2013.10

糖尿病と認知症

梅垣宏行

認知症の最新医療   Vol. 3 ( 4 ) page： 170-174   2013.10

高齢者糖尿病における生活指導のあり方

梅垣宏行

月刊糖尿病   Vol. 5 ( 4 ) page： 20-27   2013.4

Insulin resistance in the brain: a new therapeutic target for Alzheimer's disease Reviewed

Umegaki H

J Diabetes Investig   Vol. 4 ( 2 ) page： 150-1   2013.3

Cognitive impairments and functional declines in older adults at high risk for care needs Reviewed

Umegaki H, Suzuki Y, Yanagawa M, Nonogaki Z, Nakashima H, Kuzuya M, Endo H

Geriatr Gerontol Int   Vol. 13 ( 1 ) page： 77-82   2013

Cognitive dysfunction: an emerging concept of a new diabetic complication in the elderly Reviewed

Umegaki H, Hayashi T, Nomura H, Yanagawa M, Nonogaki Z, Nakshima H, Kuzuya M

Geriatr Gerontol Int   Vol. 13 ( 1 ) page： 28-34   2013

Care for Alzheimer's disease Reviewed

Umegaki H, Takechi H, Dodge H

J Alzheimers Dis     2013

Dementia and diabetes: Towards the prevention of dementia through glycemic control. Reviewed

Umegaki H

Journal of Gerontology Geriatrics Research     page： 00-00   2013

The response of the autonomic nervous system to the cholinesterase inhibitor, donepezil Reviewed

Umegaki H , Oyun Khookhor,

Neuroendocrinology Letters   Vol. 34 ( 5 ) page： 383-387   2013

Association of Chronic Kidney Disease and Cerebral Small Vessel Disease with Cognitive Reviewed

Umemura T, Kawamura T, Umegaki H, Kawano N,Mashita S, Sakakibara T, Hotta N, Sobue G.

Dement Geriatr Cogn Disord Extra   Vol. 3   page： 212-222   2013

The cholinergic stimulation of the hippocampus induced the activation of the sympathetic nervous system. Reviewed

Oyun Khookhor, Umegaki H

Neuroendocrinology Letters   Vol. 34 ( 1 ) page： 58-61   2013

第54回日本老年医学会学術集会記録 <シンポジウム8：高齢者糖尿病の管理―Ｊ-EDITから得られたもの―＞５.認知症のリスクと対応

梅垣宏行

日本老年医学会雑誌   Vol. 50 ( 1 ) page： 65-67   2013

Falls in elderly at high risk of requiring care Reviewed

Umegaki H, Suzuki Y, Yanagawa M, Nonogaki Z, Endo H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 147-148   2012

Dysphagia in older adults at high risk of requiring care Reviewed

Umegaki H, Suzuki Y, Yanagawa M, Nonogaki Z, Nakashima H, Endo H

Geriatr Gerontol Int   Vol. 12 ( 2 ) page： 359-361   2012

Neurodegeneration in diabetes mellitus Reviewed

Umegaki H

Adv Exp Med Biol   Vol. 724   page： 258-265   2012

Long-term multiple risk factor interventions in Japanese elderly diabetic patients: the Japanese Elderly Diabetes Intervention Trial--study design, baseline characteristics and effects of intervention Reviewed

Araki A, Iimuro S, Sakurai T, Umegaki H, Iijima K, Nakano H, Oba K, Yokono K, Sone H, Yamada N, Ako J, Kozaki K, Miura H, Kashiwagi A, Kikkawa R, Yoshimura Y, Nakano T, Ohashi Y, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 7-17   2012

Non-high-density lipoprotein cholesterol: an important predictor of stroke and diabetes-related mortality in Japanese elderly diabetic patients Reviewed

Araki A, Iimuro S, Sakurai T, Umegaki H, Iijima K, Nakano H, Oba K, Yokono K, Sone H, Yamada N, Ako J, Kozaki K, Miura H, Kashiwagi A, Kikkawa R, Yoshimura Y, Nakano T, Ohashi Y, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 18-28   2012

Relations of nutritional intake to age, gender and BMI in Japanese elderly patients with type 2 diabetes - Japanese Elderly Diabetes Intervention Trial(J-EDIT) Reviewed

Yoshimura Y, Kamada C,Keiko Takahashi, Kaimoto T, Iimuro S, Ohashi Y,Araki A,Umegaki H, Sakurai T, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 29-40   2012

Optimal energy distribution of carbohydrate intake for Japanese elderly patients with type 2 diabetes: the Japanese Elderly Intervention Trial Reviewed

Kamada C, Yoshimura H, Okumura R, Takahashi K, Iimuro S, Ohashi Y, Araki A, Umegaki H, Sakurai T, Yoshimura Y, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 41-49   2012

Effects of total and green vegetable intakes on glycated hemoglobin A1c and triglycerides in elderly patients with type 2 diabetes mellitus: the Japanese Elderly Intervention Trial Reviewed

Takahashi K, Kamada C, Yoshimura H, Okumura R, Iimuro S, Ohashi Y, Araki A, Umegaki H, Sakurai T, Yoshimura Y, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 50-58   2012

Dietary pattern and mortality in Japanese elderly patients with type 2 diabetes mellitus - Does vegetable- and fish-rich diet improve mortality ?: An explanatory study Reviewed

Iimuro S, Yoshimura Y, Umegaki H, Sakurai T, Araki A, Ohashi Y, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 59-67   2012

Lower Physical Activity, but not Excessive Calorie Intake, is Associated with Metabolic Syndrome in Elderly with Type 2 Diabetes Mellitus: Japanese Elderly Diabetes Intervention Trial (J-EDIT) Reviewed

Iijima K, Iimuro S, Ohashi Y, Sakurai T, Umegaki H, Araki A, Yoshimura Y, Ouchi Y, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 68-76   2012

Lower Physical Activity is a Strong Predictor of Cardiovascular Events in Elderly Patients with Type 2 Diabetes Mellitus beyond Traditional Risk Factors: Japanese Elderly Diabetes Intervention Trial (J-EDIT) Reviewed

Iijima K, Iimuro S, Shionzaki T,Ohashi Y, Sakurai T, Umegaki H, Araki A, Ouchi Y, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 77-87   2012

Effective prevention of cardiovascular disease and diabetes-related events with atorvastatin in Japanese elderly patients with type 2 diabetes mellitus: adjusting for treatment changes using a marginal structural proportional hazards model and a rank-preserving structural failure time model Reviewed

Shinozaki T, Matsuyama Y, Iimuro S, Umegaki H, Sakurai T, Araki A, Ohashi Y, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 88-102   2012

Risk factors associated with cognitive decline in the elderly with type 2 diabetes; Baseline data analysis of Japanese elderly diabetes intervention trial (J-EDIT) Reviewed

Umegaki H, Iimuro S, Shinozaki T, Araki A, Sakurai T, Iijima K, Ohashi Y, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 103-109   2012

Risk factors associated with cognitive decline in the elderly with type 2 diabetes:Pooled logistic analysis of a 6-year observation in the Japanese elderly diabetes intervention trial (J-EDIT) Reviewed

Umegaki H, Iimuro S,Shinozaki T, Araki A, Sakurai T, Iijima K, Ohashi Y, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 110-116   2012

Risk factors for a 6-year decline in physical disability and functional limitations among elderly people with type 2 diabetes (J-EDIT) Reviewed

Sakurai T, Iimuro S, Umegaki H, Araki A, Ohashi Y, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 117-126   2012

Factors associated with progression of diabetic nephropathy in Japanese elderly patients with type 2 diabetes: Sub-analysis of the Japanese Elderly Diabetes Intervention Trial Reviewed

Araki S,Nishio Y, Araki A, Umegaki H, Sakurai T, Iimuro S, Ohashi Y, Uzu T, Maegawa H, Kashiwagi A, Ito H

Geriatr Gerontol Int   Vol. 12 ( suppl 1 ) page： 127-133   2012

The effects of mild cognitive impairment on driving performance in older drivers Reviewed

Kawano N, Iwamoto K, Ebe K, Suzuki Y, Hasegawa J, Ukai K, Umegaki H, Iidaka T, Ozaki N

J Am Geriatr Soc   Vol. 60 ( 7 ) page： 1379-1381   2012

Immunohistochemical demonstration of increased prostaglandin F2alpha levels in the rat hippocampus following kainic acid-induced seizures Reviewed

Takei S, Hasegawa-Ishii S, Uekawa A, Chiba Y, Umegaki H, Hosokawa M, David F Woodward, Watanabe K, Shimada AM

Neuroscience   Vol. 218   page： 295-304   2012

Reduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: A 12-month intervention Reviewed

Haimoto H, Sasakabe T, Umegaki H, Wakai K

Diabetes Metab Syndr Obes   Vol. 5   page： 283-291   2012

Pharmacist-based Donepezil Outpatient Consultation Service to improve medication persistence Reviewed

Watanabe N, Yamamura K, Suzuki Y, Umegaki H, Shigeno K, Matsushita R, Sai Y, Miyamoto K, Yamada K

Patient Prefer Adherence   Vol. 6   page： 605-611   2012

Slower adaptation to driving simulator and simulator sickness in older adults Reviewed

Kawano N, Iwamoto K, Ebe K, Aleksic B, Noda A, Umegaki H, Kuzuya M, Iidaka T, Ozaki N

Aging Clin Exp Res   Vol. 24   page： 285-289   2012

Effective prevention of cardiovascular disease and diabetes-related events with atorvastatin in Japanese elderly patients with type 2 diabetesmellitus: adjusting for treatment changes using a marginal structural proportional hazards model and a rank-preserving structual failure time model Reviewed

Shinozaki T, Matsuyama Y, Iimuro S, Umegaki H, Sakurai T, Araki A, Ohashi Y, Ito H

Gerontol Geriatr Int   Vol. 12 ( suppl 1 ) page： 88-102   2012

Neurodegeneration dysfunction in old diabetes- management and treatment Reviewed

Umegaki H

Adv Exp Med Biol   Vol. 771   page： 465-470   2012

特集：高齢者の運転をめぐって　4.もの忘れ外来における運転指導

梅垣宏行

  Vol. 50 ( 2 ) page： 155-158   2012

特集：糖尿病患者における認知症―基礎と臨床の最新知見―Ⅲ.検査　①糖尿病患者の神経心理学的異常

梅垣宏行

月刊糖尿病   Vol. 4 ( 9 ) page： 57-64   2012

特集：アルツハイマー型認知症治療薬　ドネペジル塩酸塩が構築してきた治療エビデンス

梅垣宏行

薬局   Vol. 63 ( 2 ) page： 241-244   2012

Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse Reviewed

Hasegawa-Ishii S, Takei S, Inaba M, Umegaki H, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Shimada A.

Brain Behav Immun   Vol. 25 ( 1 ) page： 83-100   2011

Association between the caregiver's burden and physical activity in community-dwelling caregivers of dementia patients Reviewed

Hirano A, Suzuki Y, Kuzuya M, Onishi J, Hasegawa J, Ban N, Umegaki H

Arch Gerontol Geriatr   Vol. 52 ( 3 ) page： 295-298   2011

Factors Associated with Cognitive Declines in Elderly Diabetics Reviewed

Umegaki H, Kawamura T, Kawano N, Umemura T, Kanai A, Sano T

Dementia and Geriatric Cognitive Disorders Extra   Vol. 1   page： 1-9   2011

Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice Reviewed

Hasegawa-Ishii S, Takei S, Chiba Y, Furukawa A, Umegaki H, Iguchi A, Kawamura N, Yoshikawa K, Hosokawa M, Shimada A

Neuropathology   Vol. 31 ( 1 ) page： 20-28   2011

Association between improvements in insulin resistance and changes in cognitive function in elderly diabetic patients with normal cognitive function Reviewed

Yanagawa M, Umegaki H, Uno T, Oyun K, Kawano N, Maeno H, Yamanouchi K, Sato Y

Geriatr Gerontol Int   Vol. 11 ( 3 ) page： 341-7   2011

Effect of a moderate low-carbohydrate diet on preferential abdominal fat loss and cardiovascular risk factors in patients with type 2 diabetes Reviewed

Sasakabe T, Haimoto H, Umegaki H, Wakai K

Diabetes Metab Syndr Obes   Vol. 4   page： 167-74   2011

Strong association of insulin resistance with urinary albumin excretion in the elderly Reviewed

Umegaki H, Haimoto H, Isikawa J , Shibayama H, Watanabe Y

J Am Geriatr Soc   Vol. 59 ( 7 ) page： 1361-2   2011

The association of lower hemoglobin level with depressive mood in elderly women at high risk of requiring care Reviewed

Umegaki H, Yanagawa M, Endo H

Geriatr Gerontol Int   Vol. 11 ( 3 ) page： 262-6   2011

Does cerebral small vessel disease predict future decline of cognitive function in well controlled elderly patients with type 2 diabetes? Reviewed

Imamine R, Kawamura T, Umemura T, Umegaki H, Kawano N, Hotta M, Kouchi Y,Hatsuda S, Watarai A, Kanai A, Nakashima E, Sano T, Sakakibara T, Nakamura J, Hotta N

Diabetes Res Clin Pract   Vol. 94   page： 91-9   2011

Endothelial and inflammatory markers in relation to progression ofischaemic cerebral small-vessel disease and cognitive impairment: a 6-year longitudinal study in patients with type 2 diabetes mellitus Reviewed

Umemura T, Kawamura T, Umegaki H, Mashita S, Kanai R, Hotta N, Sobue G

J Neurol Neursurg Pshichiatr   Vol. 82 ( 11 ) page： 1186-1194   2011

Part2-疾患別：高齢者の栄養ケア　認知症

梅垣宏行

臨床栄養   Vol. 118 ( 6 ) page： 622-626   2011

栗田論文について（３）（レター）

梅垣宏行

日本老年医学会雑誌   Vol. 47 ( 3 ) page： 267   2010.5

認知症高齢者を対象とした音楽療法に関する文献的検討　介入頻度と効果の関係

山口理恵、河野直子、梅垣宏行

日本認知症ケア学会誌   Vol. 9 ( 1 ) page： 89-96   2010.4

Pathophysiology of cognitive dysfunction in older people with type 2 diabetes: vascular changes or neurodegeneration? Reviewed

Age Ageing.   Vol. 39 ( 1 ) page： 8-10   2010

Effects of educational background on verbal fluency task performance in older adults with Alzheimer's disease and mild cognitive impairment Reviewed

Kawano N, Umegaki H, Suzuki Y, Yamamoto S, Mogi N, Iguchi A.

Int Psychogeriatr   Vol. 22 ( 6 ) page： 995-1002   2010

Influence of regular exercise on subjective sense of burden and physical symptoms in community-dwelling caregivers of dementia patients: A randomized controlled trial Reviewed

Hirano A, Suzuki Y, Kuzuya M, Onishi J, Ban N, Umegaki H

Arch Gerontol Geriatr   Vol. 53 ( 2 ) page： e158-63   2010

Age-associated increase in abdominal obesity and insulin resistance, and usefulness of AHA/NHLBI definition of metabolic syndrome for predicting cardiovascular disease in Japanese elderly with type 2 diabetes mellitus Reviewed

Sakurai T, Iimuro S, Araki A, Umegaki H, Ohashi Y, Yokono K, Ito H

Gerontology   Vol. 56 ( 2 ) page： 141-9   2010

認知症高齢者を対象とした音楽療法に関する文献的検討　介入頻度と効果の関係

山口理恵、河野直子、梅垣宏行

認知症ケア学会誌   Vol. 9 ( 1 ) page： 89-95   2010

（座談会）期待される高齢者医療

梅垣宏行、細井孝之、浅井俊亘、牧　靖典、高橋　昇

現代医学   Vol. 58 ( 2 ) page： 297-324   2010

糖尿病における認知機能障害　Cognitive dysfunction in diabetic patients

梅垣宏行

老年期認知症研究会誌   Vol. 16   page： 99-100   2010

認知症治療薬に関する薬剤師の取り組みの今後

梅垣宏行

医薬ジャーナル   Vol. 46 ( 5 ) page： 108-110   2010

軽度認知症をスクリーニングするための神経心理学的テスト・バッテリー

河野直子、梅垣宏行

老年精神医学雑誌   Vol. 21 ( 2 ) page： 209-214   2010

Changes in the perception of dementia in Japan Reviewed

Umegaki H, Suzuki Y, Ohnishi J, Iguchi A

Int Psychogeriatr.   Vol. 21 ( 4 ) page： 793-7   2009

Responses of hypothalamo-pituitary-adrenal axis to a cholinesterase inhibitor Reviewed

Umegaki H, Yamamoto A, Suzuki Y, Iguchi A

Neuroreport   Vol. 20 ( 15 ) page： 1366-70   2009

Acute metabolic responses to a high-carbohydrate meal in outpatients with type 2 diabetes treated with a low-carbohydrate diet: a crossover meal tolerance study Reviewed

Haimoto H, Sasakabe T, Umegaki H, Wakai K

Nutr Metab (Lond)   Vol. 6 ( 1 ) page： 52   2009

Low HDL-cholesterol is associated with the risk of stroke in elderly diabetic individuals: Changes in the risk for atherosclerotic diseases at various ages Reviewed

Hayashi T, Kawashima S, Itoh H, Yamada N, Sone H, Watanabe H, Hattori Y, Ohrui T, Yokote K, Nomura H, Umegaki H, Iguchi A; on behalf of Japan CDM group

Diabetes Care   Vol. 32 ( 7 ) page： 1221-3   2009

Effects of a low-carbohydrate diet on glycemic control in outpatients with severe type 2 diabetes Reviewed

Haimoto H, Sasakabe T, Wakai K, Umegaki H

Nutr Metab (Lond)   Vol. 6   page： 21   2009

Association of higher carbohydrate intake with depressive mood in elderly diabetic women Reviewed

Umegaki H, Iimuro S, Araki A, Sakurai T, Iguchi A, Ohashi Y, Ito H

Nurtritional Neuroscience   Vol. 12 ( 6 ) page： 267-71   2009

Different contribution of the lateral bed nucleus of the stria terminalis in intrahippocampal neostigmine-induced elevation of plasma glucoseand adrenocorticotropic hormone in free moving rats Reviewed

Zhu W, Cui J, Zhang R, Umegaki H

Neuroendocrinology Letter   Vol. 30 ( 4 ) page： 511-4   2009

ＭＭＳＥ２４点以上の高齢者群における神経心理学的検査を用いた認知症の探索

河野直子、鈴木裕介、山本さやか、井口昭久、梅垣宏行

Dementia Japan   Vol. 22 ( 3 ) page： 298-307   2009

Factors Associated with Lower Mini Mental State Examination Scores in Elderly Japanese Diabetes Mellitus Patients Reviewed

Umegaki H Satoshi Iimuro, Si Kaneko T, Araki A, Sakurai T Ohashi Y, Akihisa Iguchi A, Ito H

Neurobiol Aging   Vol. 29 ( 7 ) page： 1022-6   2008

Visceral fat contribution of insulin resistance in elderly people Reviewed

Umegaki H, Haimoto H, Ishikawa J, Kario K.

J Am Geriatr Soc   Vol. 56 ( 7 ) page： 1373-1375   2008

Aging of the striatum: mechanisms and interventions Invited Reviewed

Umegaki H, Roth GS, Ingram DK.

Age   Vol. 30 ( 4 ) page： 251-261   2008

D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats Reviewed

Thanos PK, Michaelides M, Umegaki H, Volkow ND

Synapse   Vol. 62 ( 7 ) page： 481-6   2008

Long-term effects of a loose restriction of carbohydrates diet on HbA1c levels, BMI and tapering of sulfonylureas in type 2 diabetes: a two-year follow-up study Reviewed

Haimoto H, Iwata M, Wakai K, Umegaki H

Diab Res Clin Prac   Vol. 79 ( 2 ) page： 350-6   2008

Importance of Lipid Levels in Elderly Diabetic Individuals. Reviewed

Hayashi T, Kawashima S, Itoh H, Yamada N, Sone H, Watanabe H, Hattori Y, Ohrui T, Yoshizumi M, Yokote K, Kubota K, Nomura H, Umegaki H, Iguchi A; on behalf of Japan CDM group

Circ J   Vol. 72 ( 2 ) page： 218-25   2008

Effect of the entorhinal cortex on diurnal ACTH and corticosterone release in rats Reviewed

Zhu W, Zhang R, Changchun H, Umegaki H

Neuroendocrinol lett   Vol. 29 ( 1 ) page： 159-62   2008

Discontinuation of Donepezil for the Treatment of Alzheimer's Disease in Geriatric Practice Reviewed

Umegaki H, Itoh A, Suzuki Y, Nabeshima T

Int. Psychogeriatr.   Vol. 20 ( 4 ) page： 800-6   2008

Cognitive Dysfunction in Diabetic Elderly Reviewed

Umegaki H, Kawamura T, Mogi N, Umemura T, Kanai A, Sano T

Age Ageing   Vol. 37 ( 4 ) page： 458-61   2008

高齢者のメタボリックシンドローム (Invited Review)

梅垣宏行

日老医誌   Vol. 45 ( 3 ) page： 330-334   2008

Attitudes toward disclosing the diagnosis of dementia in Japan Reviewed

Umegaki H, Onishi J, Suzuki Y, Endo H, Iguchi A

Int. Psychogeriatr   Vol. 19 ( 2 ) page： 253-265   2007

Clinical profiles of autopsy-confirmed dementia with Lewy bodies at institutionalization: Comparison with Alzheimer's disease Reviewed

Fujishiro H, Umegaki H, Suzuki Y, Isojima D, Akatsu H, Ikari H, Iguchi A, Kosaka K

Psychogeriatrics   Vol. 7 ( 3 ) page： 98-103   2007

Which two questions of Mini-Mental State Examination (MMSE) should we start from? Reviewed

Onishi J, Suzuki Y, Umegaki H, Kawamura T, Imaizumi M, Iguchi A

Arch Gerontol Geriatr   Vol. 44 ( 1 ) page： 43-8   2007

認知症診療に対する態度に関する医師会会員へのアンケート調査-地域における認知症の診療体制の確立のために-

梅垣宏行、鈴木裕介、葛谷雅文、井口昭久

日老医誌   Vol. 44   page： 102-106   2007

老年科における外来認知症診療の現状と展望：名古屋大学医学部附属病院老年科「外来もの忘れ検査」の利用統計から

河野直子、梅垣宏行、茂木七香、山本さやか、鈴木裕介、井口昭久

日老医誌   Vol. 44   page： 611-618   2007

ADAS単語カードを用いた遅延再生課題の軽度認知機能低下識別に対する有用性：外来もの忘れ検査利用者を対象とした検討

河野直子、梅垣宏行、鈴木裕介、山本さやか、茂木七香、井口昭久

日老医誌   Vol. 44 ( 4 ) page： 490-496   2007

Functional Recovery of the Striatal Cholinergic System in Aged Rats by Adenoviral Vector-mediated Gene Transfer of Dopamine D2 Receptor Reviewed

Umegaki H, Yamaguchi Y, Ishiwata, K, Roth GS, Ingram DK, Iguchi A

  Vol. 127 ( 10 ) page： 813-815   2006

Behavioral, Psychological, and Physical Symptoms in Group Homes for the Older Adults with Dementia Reviewed

Onishi J, Suzuki Y, Umegaki H, Endo H, Kawamura T, Imaizumi M, Iguchi A

Int Psychogeriatr   Vol. 3   page： 1-12   2006

Association between insulin resistance and cognitive function in elderly diabetic patients Reviewed

Suzuki M, Umegaki H, Uno T, Oyun, O, Mogi N, Maeno H, Yamanouchi K, Iguchi A, Sato Y

Geriatr. Gerotr, Intr   Vol. 6   page： 254-9   2006

Stimulation of the Hippocampal Glutamate Receptor Systems Induces Stress-like Responses Reviewed

Umegaki H, Yamamoto A, Suzuki Y, Iguchi A

Neuroendocrinology letters   Vol. 27 ( 3 ) page： 339-43   2006

Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese Elderly Diabetes Intervention Trial (J-EDIT) Reviewed

Akisaki T, Sakurai T, Takata T, Umegaki H, Araki A, Mizuno S, Tanaka S, Ohashi Y, Iguchi A, Yokono K and Ito H

Diabetes/Met Res Rev   Vol. 22 ( 5 ) page： 376-84   2006

Microdialysis measurement of acetylcholine in rat hippocampus during severe insulin-induced hypoglycemia. Reviewed

Umegaki H, Yamaguchi Y, Suzuki Y, Iguchi A

Neuroendocrinol lett   Vol. 27 ( 1-2 ) page： 128-32   2006

Cognitive Function in the Elderly with Diabetes Mellitus Reviewed

Umegaki H, Iguchi A

J Clin Biochem Neutr   Vol. 38 ( 1 ) page： 19-24   2006

Factors associated with cognitive impairment in elderly diabetes mellitus patients Reviewed

Suzuki M, Umegaki H, Ieda S, Mogi N, Iguchi A

J Am Geriatr Soc   Vol. 54 ( 3 ) page： 558-9   2006

A Comparison of Depressive Mood of older adults in a Community, Nursing Homes, and a Geriatric Hospital: Factor Analysis of Geriatric Depression Scale Reviewed

Onishi J, Suzuki Y, Umegaki H, Endo H, Kawamura T, Iguchi A

J Geriatr Psychiatry Neurol   Vol. 19 ( 1 ) page： 26-31   2006

Depletion of cholinergic neurons in nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies. Invited Reviewed

Fujishiro H. Umegaki H, Isojima D, Akatsu H, Iguchi A, Kosaka K

Acta Neuropathol   Vol. 11 ( 2 ) page： 109-14   2006

痴呆と未病

梅垣宏行

日老医誌   Vol. 43 ( 1 ) page： 87-88   2006

日本人高齢糖尿病の認知症、認知機能低下の危険因子—J-EDIT登録症例を用いた検討

梅垣宏行、櫻井孝、荒木厚、飯室聡、大橋靖雄、井藤英喜

糖尿病合併症   Vol. 20 ( 1 ) page： 71-74   2006

Dopamine D2 receptor has a role in memory function. Implications for dopamine-acetylcholine interaction in the ventral hippocampus Reviewed

Fujishiro H, Umegaki H, Suzuki Y, Oohara-Kurotani S, Yamaguchi Y, Iguchi A

Psychopahrmacology   Vol. 182 ( 2 ) page： 253-61   2005

Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: Effects on ethanol drinking Reviewed

Thanos PK , Rivera SN, Weaver K,. Grandy DK, Rubinstein M, Umegaki H , Wang GJ , Hitzemann R ,Volkow ND

Life Sciences   Vol. 77   page： 130-139   2005

The entorhinal cortex regulates blood glucose level in response to microinjection of neostigmine into the hippocampus Reviewed

Adeli-Rankouhi S, Umegaki H, Zhu W, Suzuki Y, Kurotani S, Ieda S, Iguchi A

Neuroendocrinol lett   Vol. 26   page： 225-230   2005

Influence of behavioral and psychological symptoms of dementia (BPSD) and environment of care on caregivers' burden Reviewed

Onishi J, Suzuki Y, Umegaki H, Nakamura A, Endo H, Iguchi A

Arch Gerontol Geriatr   Vol. 41 ( 2 ) page： 159-68   2005

名古屋市保健所における痴呆介護予防事業参加者の意識調査

藤城弘樹、梅垣宏行、鈴木裕介、中村　了、平川仁尚、井口昭久

日老医誌   Vol. 42   page： 340-345   2005

Cognitive Function in Japanese Elderly with Type 2 Diabetes Mellitus Reviewed

. Mogi N, Umegaki H, Hattori A, Maeda N, Miura H, Kuzuya M, Shimokata H, Ando F, Ito H, Iguchi A

J Diabetes Complict   Vol. 18   page： 42-46   2004

DRD2 Gene Transfer Into the Nucleus Accumbens Core of the Alcohol Preferring and Nonpreferring Rats Attenuates Alcohol Drinking Reviewed

Thanos PK , Rivera SN, Weaver K,. Grandy DK, Rubinstein M, Umegaki H , Wang GJ , Hitzemann R ,Volkow ND

Alcohol Clin Exp Res   Vol. 5   page： 720-728   2004

The Relationship between Functional Disability and Depressive Mood in Japanese Older Adult Inpatients Reviewed

Onishi J, Umegaki H, Suzuki Y, Uemura K, Kuzuya M, Iguchi A

J Geriatr Psychiatr Neurol   Vol. 17 ( 2 ) page： 93-98   2004

The Clock Drawing Test as a Valid Screening Method for Mild Cognitive Impairment Reviewed

Yamamoto S, Mogi N, Umegaki H, Suzuki Y, Ando F, Shimokata H, Iguchi A

Dementi Geriatr Cogn   Vol. 18 ( 2 ) page： 172-179   2004

Smell identification test as an indicator for cognitive impairment in Alzheimer's disease. Reviewed

Suzuki Y, Yamamoto S, Umegaki H, Onishi J, Mogi N, Fujishiro H, Iguchi A

Int J Geriatr Psychiatry   Vol. 19 ( 8 ) page： 727-33   2004

「高齢者医療の現状と展望」　最近のトピックス　諸外国における高齢者医療の現状

遠藤英俊, 大島伸一, 三浦久幸, 大西丈二, 梅垣宏行, 鈴木裕介, 井口昭久

日本内科学会雑誌   Vol. 93 ( 12 ) page： 2599-2602   2004

Longitudinal follow-up study of adenoviral vector-mediated gene transfer of dopamine D2 receptors in the striatum in young, middle-aged, and aged rats: a positron emission tomography study

Umegaki H, Ishiwata K, Ogawa O, Ingram DK, Roth GS, Oda K, Kurotani S, Kawamura K, Wang WF, Ikari H, Senda M, Iguchi A

Neuroscience   Vol. 121   page： 479-486   2003

Atrovastatin, 3-Hydroxy 3- Methylglutaryl Coenzyme A Reductase Inhibitor, reduces bone resorption in the elderly. Reviewed

Kuzuya M, Suzuki Y, Asai T, Koike T, Kanda S, Nakamura A, Satake S, Umegaki H, Iguchi A

JAGS   Vol. 51   page： 1677-1678   2003

Different glial reaction to hippocampal stab wounds in young adult and aged rats Reviewed

Zhu W, Umegaki H, Shinkai T, Kurotani S, Suzuki Y, Endo H, Iguchi A

J Gerontol A Biol Sci Med Sci   Vol. 58 ( 2 ) page： B117-22   2003

Involvement of the entorhinal cortex in the stress response to immobilization, but not to insulin-induced hypoglycemia Reviewed

Umegaki H, Zhu W, Nakamura A, Suziki Y, Takada M, Endo H, Iguchi A

J Neuroendocrinol   Vol. 15   page： 237-241   2003

Identification of factors associated with long hospital stay in Japanese geriatric ward Reviewed

Umegaki H, Ando F, Shimokata H, Yamamoto S, Nakamura A, Endo H, Kuzuya M, Iguchi A.

Geriatr Gerintol Int   Vol. 3 ( 2 ) page： 120-7   2003

The Age-Associated Changes of Dopamine-Acetylcholine Interaction in the Striatum. Reviewed

Kurotani S, Umegaki H, Ishiwata K, Suzuki Y, Iguchi A

Exp. Gerontol   Vol. 38/39   page： 1009-13   2003

In vivo assessment of adenoviral vector-mediated gene expression of dopamine D2 receptors in the rat striatum by positron emission tomography

Umegaki H, Ishiwata K, Ogawa O., Ingram DK, Roth GS, Yoshimura J, Oda K, Matsui-Hirai H, Ikari H, Iguchi A, Senda M

Synapse   Vol. 43   page： 195-200   2002

Plasma Insulin and Glucose Levels in Elderly Female Subjects with Alzheimer's Disease Reviewed

Umegaki H, Ushida C, Ikari H, Ogawa O, Nakamura A, Suzuki Y, Endo H, Akatsu H, Yamamoto T, Iguchi A

Geriatr Gerontol Int   Vol. 2   page： 75-9   2002

Positron emission tomography and ex vivo and in vitro autradiography studies on dopamin D2-like receptor degeneration in quinolinic acid- lesioned rat striatum. Reviewed

Ishiwata K, Ogi N, Hayakawa N, Umegaki H, Nagaoka T, Oda K, Toyama H, Endo K, Tanaka A, Senda M

Nuclear Medicine and biology   Vol. 29   page： 307-16   2002

Involvement of dopamine D2 receptor in complex maze and acetylcholine release in ventral hippocampus of rats Reviewed

Umegaki H, Munoz J, Meyer RC, Spangler EL, Yoshimura J, Ikari H, Iguchi A, Ingram DK

Neuroscience   Vol. 103 ( 1 ) page： 27-33   2001

Assessment of brain atrophy in elderly subjects with diabetes mellitus by computed tomography Reviewed

Ushida C, Umegaki H, Hattori A, Mogi N, Aoki S, Iguchi A

Geriatr Gerontol Int   Vol. 1   page： 33-7   2001

The elevation of plasma adrenocorticotrophic hormone and expression of c-Fos in hypothalamic paraventricular nucleus by microinjection of neostigmine into the hippocampus in rats: comparison with acute stress responses. Reviewed

Zhu W, Umegaki H, Yoshimura J, Tamaya N, Suzuki Y, Miura H, Iguchi A

Brain Res   Vol. 892 ( 2 ) page： 391-5   2001

Overexpression of dopamine D2 receptors reduces alcohol self-administration Reviewed

Thanos PK, Volkow ND, Freimuth P, Umegaki H, Ikari H, Roth GS, Ingram DK, Hitzemann R

J Neurochem   Vol. 78 ( 5 ) page： 1094-103   2001

Involvement of the bed nucleus of the stria terminalis in hippocampal cholinergic system-mediated activation of the hypothalamo-pituitary-adrenocortical axis in rats Reviewed

Zhu W, Umegaki H, Suzuki Y, Miura H, Iguchi A

Brain Res   Vol. 916   page： 101-6   2001

Dietary restriction of choline reduces hippocampal acetylcholine release in rats: in vivo microdialysis study. Reviewed

Nakamura A, Suzuki Y, Umegaki H, Ikari H, Tajima T, Endo H, Iguchi A

Brain Res Bull   Vol. 56 ( 6 ) page： 593-7   2001

The metabolism of plasma glucose and catecholamines in Alzheimer's disease Reviewed

Umegaki H, Tamaya N, Shinkai T, Iguchi A

Exp. Gerontol   Vol. 35 ( 9-10 ) page： 1373-82   2000

Development of an adenoviral vector for intracerebral delivery of the dopamine D2 receptor. Reviewed

Ingram DK, Umegaki H, Ikari H, Roth G.S

Mech Ageing Dev   Vol. 116 ( 2-3 ) page： 77-93   2000

Plasma cortisol levels in elderly female subjects with Alzheimer's disease: a cross-sectional and longitudinal study. Reviewed

Umegki H, Ikari H, Nakahata H, Endo H, Suzuki Y, Ogawa O, Nakamura A, Yamamoto T, Iguchi A

Brain Res   Vol. 881 ( 2 ) page： 241-3   2000

Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in beta-amyloid protein-stimulated J774 cells Reviewed

Ogawa O, Umegaki H, Sumi D, Hayashi T, Nakamura A, Thakur NK, Yoshimura J, Endo H, Iguchi A

Eur. J. Pharmacol   Vol. 408 ( 2 ) page： 137-41   2000

In vivo imaging of adenovirus-mediated over-expression of dopamine D2 receptors in rat striatum by positron emission tomography Reviewed

Ogawa O, Umegaki H, Ishiwata K, Asai Y, Ikari H, Oda K, Toyama H, Ingram DK, Roth G.S, Iguchi A, Senda M

Neuroreport   Vol. 11 ( 4 ) page： 743-8   2000

Low plasma epinephrine in elderly female subjects of dementia of Alzheimer's type. Reviewed

Umegaki H, Ikari H, Nakahata H, Yoshimura J, Endo H, Yamamoto T, Iguchi A

Brain Res   Vol. 858   page： 67-70   2000

Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway Reviewed

Luo Y, Umegaki H, Wang X, Abe R, Roth GS

J Biol Chem   Vol. 273 ( 6 ) page： 3756-64   1998

Application of Gene Therapy to Treat Age-Related Loss of Dopamine D2 Receptor Reviewed

Ingram DK, Ikari H, Umegaki H, Chernak JM, Roth GS

Exp. Gerontol   Vol. 33 ( 7-8 ) page： 793-804   1998

Intrastriatal injection of dopamine results in DNA damage and apoptosis in rats Reviewed

Hattori A, Luo Y, Umegaki H, Munoz J, Roth GS

Neuroreport   Vol. 9 ( 11 ) page： 2569-72   1998

Rotational behavior produced by adenovirus-mediated gene transfer of dopamine D2 receptor into rat striatum Reviewed

Umegaki H, Chernak JM, Ikari H, Roth GS, Ingram DK

Neuroreport   Vol. 8 ( 16 ) page： 3553-8   1997

Possible involvement of catalase in the protective effect of interleukin-6 against 6-hydroxydopamine toxicity in PC12 cells Reviewed

Yamada K, Umegaki H, Maezawa I, Iguchi A, Kameyama T, Nabeshima T

Brain Res. Bull   Vol. 43 ( 6 ) page： 573-7   1997

Nabeshima T. Protective effect of interleukin-6 against the death of PC12 cells caused by serum deprivation or by the addition of a calcium ionophore Reviewed

Umegaki H, Yamada K, Naito M, Kameyama T, Iguchi A

Biochem Pharmacol   Vol. 52 ( 6 ) page： 911-6   1996

Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia Reviewed

Yamada K, Kono K, Umegaki H, Yamada K, Iguchi A, Fukatsu T, Nakashima N, Nishiwaki H, Shimada Y, Sugita Y, Yamamoto T, Hasegawa T, Nabeshima T

Neurosci. Lett   Vol. 186 ( 2-3 ) page： 219-221   1995

Protective effects of probucol against glutamate-induced cytotoxicity in neuronal cell line PC12 Reviewed

Naito M, Umegaki H, Iguchi A

Neurosci. Lett   Vol. 186 ( 2-3 ) page： 211-3   1995

『ケースに学ぶ　高齢者糖尿病の診かた』第Ⅲ部　「22.認知症にはどう対応する？」「24.認知症では服薬回数を減らすべき？」

梅垣宏行（ Role： Sole author）

㈱南山堂  2017.4 

「高齢者理学療法学」 服薬確認

梅垣宏行（ Role： Sole author）

医歯薬出版株式会社  2017.3 

これからの在宅医療ガイド　―我々は被災地から何を学んだか― Ⅰ在宅医療は患者家族にとっていいものか？ 在宅医療のQOL指標の開発、試用

葛谷雅文・梅垣宏行（ Role： Joint author）

㈱グリーン・プレス  2016.7 

『臨床栄養』別冊JCNセレクト「高齢者の健康寿命栄養戦略」 ・Ⅲ疾病予防・重症化予防 7.認知症.栄養・運動による認知症の発症・重症化予防.

梅垣宏行（ Role： Joint author）

医歯薬出版株式会社  2016.4 

『介護福祉士実務者研修テキスト　第４巻　発達と老化の理解・こころとからだのしくみ』　第１部「発達と老化の理解」第２章「老化に伴うこころとからだの変化と日常生活」

梅垣宏行（ Role： Sole author）

社会福祉法人　全国社会福祉協議会  2016.3 

『病気とくすり』・認知症.

梅垣宏行（ Role： Joint author）

南山堂  2016.3 

糖尿病ケア・ 特集　患者さんと医療者の不安を解決　認知症なんでもQ＆A.・認知症を予防するために何をすればよいですか。・認知症になったらもう治療法はないのですか。

梅垣宏行（ Role： Joint author）

メディカ出版  2016.1 

これからの在宅医療ガイド　―我々は被災地から何を学んだか―　在宅医療のQOL指標の開発、試用

大島真一　他　葛谷雅文、梅垣宏行（ Role： Joint author）

㈱グリーン・プレス  2016 

“最新研究”から“医療者＆患者さんのギモン”まで　◎患者さんの疑問編　3.4.

梅垣宏行（ Role： Sole author）

糖尿病ケア誌  2015.12 

ココに注意！高齢者の糖尿病　老年症候群を考えた治療とＱＯＬを高める療養指導のコツ

荒木　厚／編（ Role： Joint author）

羊土社  2015.1 

『かかりつけ医のための老年病100の解決法』急に血糖コントロールの悪化した糖尿病患者への対応について

梅垣宏行（ Role： Sole author）

メディカルレビュー社  2015 

フレイルティ　－高齢社会における最重要課題と予防戦略

葛谷雅文 他（ Role： Joint author）

医歯薬出版株式会社  2014.6 

治療が劇的にうまくいく！高齢者の栄養　はじめの一歩　身体機能を低下させない疾患ごとの栄養管理のポイント

大村健二，葛谷雅文　他（ Role： Joint author）

羊土社  2013.2 

高齢者のための薬の使いかた　ストップとスタート

秋下　雅弘 他（ Role： Joint author）

ぱーそん書房  2013 

機能性食品素材と運動療法―生活習慣病予防と運動機能維持、向上をめざして―

大澤俊彦・佐藤祐造他（ Role： Joint author）

シーエムシー出版  2012.6 

老年医学up date 2009-10

小原克彦、斎藤重幸 他（ Role： Joint author）

MEDICAL VIEW社  2009.6 

老年医学テキスト　改訂版

社団法人　日本老年医学会（ Role： Joint author）

メジカルビュー社  2008.6 

ベッドサイドの高齢者の診かた

葛谷雅文, 秋下雅弘 他（ Role： Joint author）

南山堂  2008.3 

次世代の医学・医療がわかる　未病医学 入門

都島基夫、福生吉宏他（ Role： Joint author）

金芳堂  2006 

地域在住高齢者の身体活動量と転倒恐怖感との関連の検討

梅垣宏行、牧野多恵子、上村一貴、葛谷雅文

第６１回日本老年医学会学術集会 

高齢糖尿病患者の薬物療法の注意点

梅垣宏行

第３回　老年薬学会 

フレイルと認知症

梅垣宏行

第６３回　日本リユウマチ学会総会・学術集会 

社会的孤立と認知機能の関連の検討

梅垣宏行、牧野多恵子、葛谷雅文

第３７回日本認知症学会学術集会　 

ファシリテーター

梅垣宏行

高齢者医療研修会 

在宅高齢者における不適切処方と入院との関連の検討

梅垣宏行、野村秀樹、神田　茂、紙谷博子、渡邉雄貴、中嶋宏貴、小宮　仁、渡邊一久、葛谷雅文

第６０回日本老年医学会学術集会 

地域在住高齢者におけるプレフレイルと転倒の関連に関する検討

梅垣宏行、牧野多恵子、上村一貴、島田裕之、葛谷雅文

第６０回日本老年医学会学術集会 

高齢者のインスリン抵抗性と身体活動量の関連

梅垣宏行、牧野多恵子、渡邉 一久、葛谷 雅文

第61回日本糖尿病学会年次学術集会 

高齢糖尿病患者の血圧・脂質管理

梅垣宏行

第５２回糖尿病学の進歩 

ＭＣＩから軽度ＡＤ患者の認知機能とＱＯＬの関連

梅垣宏行、紙谷博子、牧野多恵子、栁川まどか、葛谷雅文、櫻井　孝

第３６回日本認知症学会学術集会 

他領域での認知症予防

梅垣宏行

日本認知症予防学会　学術集会 

フレイルな高齢糖尿病患者の病態と治療

梅垣宏行

第２２回日本糖尿病教育・看護学会　学術集会 

訪問診療をうける高齢者の栄養状態の悪化に関する因子の検討

梅垣宏行、浅井真嗣、神田茂、野村秀樹、前田恵子、下島卓弥、葛谷雅文

第１９回　日本在宅医学会大会 

認知機能障害と身体機能・身体組成の関連

梅垣宏行、牧野多恵子、栁川まどか、中嶋宏貴、小宮　仁、葛谷雅文

第５９回日本老年医学会学術集会 

地域での認知症予防のための栄養指導

第５９回日本老年医学会学術集会

地域での認知症予防のための栄養指導 

訪問診療をうける高齢者のQOLに関連する因子の検討

梅垣宏行、紙谷博子、神田茂、野村秀樹、前田恵子、葛谷雅文

第５９回日本老年医学会学術集会 

高齢糖尿病患者のフレイルと認知機能の関連

梅垣宏行、牧野多恵子、林尊弘、葛谷雅文

第60回日本糖尿病学会年次学術集会 

フレイルな高齢者への栄養・運動療法

梅垣宏行

第２０回日本病態栄養学会年次学術集会 

地域在住高齢者におけるインスリン抵抗性と認知機能の関連

梅垣 宏行、牧野 多恵子、上村一貴、島田 裕之、葛谷 雅文

第３５回　日本認知症学会学術集会 

「在宅医療における生活習慣病ならびに疾病管理基準－ガイドラインとの整合性と抱えている課題」 在宅医療における糖尿病管理

梅垣宏行

第１８回　日本在宅医学会大会　第２１回　日本在宅ケア学会学術集会合同大会 

非癌在宅医療受療者における入院および死亡の関連因子の検討

梅垣宏行、神田　茂、野村秀樹、前田恵子、葛谷雅文

第５８回　日本老年医学会学術集会 

高齢糖尿病患者の認知機能低下と血糖・血圧コントロールの関係―9 年間の観察研究

梅垣宏行

第５９回 日本糖尿病学会年次学術集会 

高齢者におけるサルコペニア・フレイル

梅垣宏行

第２０回日本体力医学会東海地方会学術集会 

糖尿病患者の認知機能障害

梅垣宏行

第３０回日本糖尿病合併症学会 

在宅医療をうける高齢者における在宅医療の中断に関する認知症の影響―ONEHOME研究

梅垣宏行、浅井真嗣、神田茂、野村秀樹、前田恵子、葛谷雅文

第３４回日本認知症学会学術集会 

教育企画『地域包括ケア実現に向けての課題と対策』

梅垣宏行

第２６回日本老年医学会東海地方会 

認知機能

梅垣宏行

第５回日本認知症予防学会学術集会 

SPECT Findings and Neuropsychological Assessments in Older Alzheimer's Disease International conference

Hiroyuki Umegaki

SPECT Findings and Neuropsychological Assessments in Older Alzheimer's Disease 

在宅医療における入院・入所・死亡に関連する因子の検討

梅垣宏行、野村秀樹、神田　茂、前田恵子、小笠原真雄、神谷博子、鈴木裕介、葛谷雅文

第57回日本老年医学会学術集会 

在宅医療をうける高齢者における最近の入院に対する糖尿病の影響

梅垣宏行、浅井真嗣、神田茂、野村秀樹、下島卓也、前田恵子、小笠原文雄、葛谷雅文　

第58回日本糖尿病学会年次学術集会 

高齢糖尿病患者におけるサルコペニア・フレイル・ＡＤＬ低下

梅垣宏行

第58回日本糖尿病学会年次学術集会 

アルツハイマー型認知症の認知機能への糖尿病の合併の影響

梅垣宏行、牧野多恵子、一柳知里、葛谷雅文

第58回日本糖尿病学会年次学術集会 

在宅医療におけるＱＯＬ評価のための評価表の作成

梅垣宏行

第17回　日本在宅医学会もりおか大会 

これからの高齢者糖尿病医療に必要な知識とスキル

梅垣宏行

第４９回　糖尿病学の進歩 

超高齢社会におけるサルコペニア、フレイルの意義を問う

梅垣宏行

第１回日本サルコペニア・フレイル研究会研究発表会 

The prevalence of homebound individuals in the elderly population: A survey in a city area in Japan. International conference

10th Interntional Congress of the European Union Geriatric Medicine Society 

高齢者と認知・判断・行動

梅垣宏行

第２３回　日本交通医学工学研究会　学術総会 

Treatment of elderly with diabetes: Cognitive dysfunction International conference

The 20th IAGG World Congress of Gerontology and Geriatrics 

The perception of dementia in general population in Japan International conference

Alzheimer's Association International Conference 

教育企画「高齢者の介護・看護・医療」

梅垣宏行

第23回日本老年医学会東海地方会 

特定高齢者における認知機能低下と転倒との関連

梅垣宏行、柳川まどか、野々垣　禅、中嶋宏貴、葛谷雅文

日本認知症予防学会学術集会 

高齢者糖尿病の管理―Ｊ－ＥＤＩＴ研究から得られたもの―

梅垣宏行

第54回日本老年医学会学術集会 

認知症予防の最前線―現在そして将来、どこまでできるか

梅垣宏行

第18回日本未病システム学会学術総会 

特定高齢者の認知機能低下に関連する因子の検討

梅垣宏行、鈴木裕介、遠藤英俊

第30回日本認知症学会学術集会 

アルツハイマー型認知症患者の生活習慣病とsmall-vessel diseaseの認知機能への影響

梅垣宏行、牧野多恵子、鈴木裕介、山本さやか、河野直子

第30回日本認知症学会学術集会 

特定高齢者の嚥下機能低下に関連する因子の検討

梅垣宏行、柳川まどか、野々垣　禅、遠藤英俊

第53回日本老年医学会学術集会 

高齢糖尿病患者の認知機能低下に関連する因子の検討（J-EDIT study）

梅垣宏行、飯室　聡、荒木　厚、櫻井　孝、飯島勝矢、井藤英喜

第53回日本老年医学会学術集会 

認知機能障害と糖尿病

梅垣宏行

第３２回日本臨床栄養学会総会・第３１回日本臨床栄養協会総会 

特定高齢者の転倒に関連する因子の検討

梅垣宏行

第５２回日本老年医学会学術集会 

Driving problems arising from dementia and various cognitive impairment International conference

22nd annual meeting of JPS, 26th annual meeting of JSDR 

The impaired imitation of meaningless-movement in mild cognitive impairment and early-stage Alzheimer's disease International conference

22nd annual meeting of JPS, 26th annual meeting of JSDR 

Strategy for Prevention of Alzheimer's Disease International conference