研究者詳細 - 岩野　信吾

論文 - 岩野　信吾

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Increased sputum peripheral helper T cells are associated with the severity of rheumatoid arthritis but not with the severity of airway disease Open Access

Yokoi, E; Wakahara, K; Nakamura, S; Fukutani, E; Asai, S; Takahashi, N; Kojima, T; Iwano, S; Shimada, S; Chen-Yoshikawa, TF; Hashimoto, N; Ishii, M

FRONTIERS IN IMMUNOLOGY 16 巻頁： 1526881 2025年2月

Blood eosinophil count correlates with alveolar damage in emphysema-predominant COPD

Nakamura, S; Wakahara, K; Majima, S; Yokoi, E; Fukutani, E; Otsuki, R; Iwano, S; Chen-Yoshikawa, TF; Kinoshita, F; Abe, T; Sashio, T; Kimura, T; Izuhara, K; Hashimoto, N; Ishii, M; Hasegawa, Y

BMC PULMONARY MEDICINE 24 巻 ( 1 ) 頁： 510 2024年10月

Diagnostic Value and Safety of Addition of Transbronchial Needle Aspiration to Transbronchial Biopsy Through Endobronchial Ultrasonography Using a Guide Sheath Under Virtual Bronchoscopic Navigation for the Diagnosis of Peripheral Pulmonary Lesions

Ito, T; Nishida, K; Iwano, S; Okachi, S; Nakamura, S; Morise, M; Toyofumi, CYF; Ishii, M

JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY 31 巻 ( 4 ) 2024年10月

Development of automatic generation system for lung nodule finding descriptions

Momoki, Y; Ichinose, A; Nakamura, K; Iwano, S; Kamiya, S; Yamada, K; Naganawa, S

PLOS ONE 19 巻 ( 3 ) 頁： e0300325 2024年3月

Airway involvement in inflammatory bowel disease: Inflammatory bowel disease patients have bronchial wall thickening 査読有り

Majima, S; Wakahara, K; Iwano, S; Kinoshita, F; Nakamura, M; Hashimoto, N; Fujishiro, M; Hasegawa, Y

RESPIRATORY INVESTIGATION 60 巻 ( 5 ) 頁： 713 - 719 2022年9月

Computer-Aided Volumetry by Multidetector Computed Tomography is Efficient for Prognostic Prediction of Early-Stage Solid Lung Cancers

Kato, T; Iwano, S; Katsuya, R; Okado, S; Ito, T; Sato, K; Nakanishi, K; Kadomatsu, Y; Ueno, H; Ozeki, N; Nakamura, S; Fukumoto, K; Chen-Yoshikawa, TF

JOURNAL OF THORACIC ONCOLOGY 17 巻 ( 9 ) 頁： S206 - S207 2022年9月

Right ventricular pressure overload related to residual thrombotic burden in patients 1 year after acute pulmonary embolism: From the Nagoya PE study

Nakano, Y; Adachi, S; Nishiyama, I; Yasuda, K; Yoshida, M; Iwano, S; Kondo, T; Murohara, T

THROMBOSIS RESEARCH 216 巻頁： 113 - 119 2022年8月

Usefulness of a refined computed tomography imaging method to assess the prevalence of residual pulmonary thrombi in patients 1 year after acute pulmonary embolism: The Nagoya PE study 査読有り

Nakano, Y; Adachi, S; Nishiyama, I; Yasuda, K; Imai, R; Yoshida, M; Iwano, S; Kondo, T; Murohara, T

JOURNAL OF THROMBOSIS AND HAEMOSTASIS 20 巻 ( 4 ) 頁： 888 - 898 2022年4月

End-Systolic Eccentricity Index Obtained by Enhanced Computed Tomography Is a Predictor of Pulmonary Vascular Resistance in Patients with Chronic Thromboembolic Pulmonary Hypertension 招待有り査読有り

Tsutsumi, Y; Adachi, S; Nakano, Y; Iwano, S; Abe, S; Kato, K; Naganawa, S

LIFE-BASEL 12 巻 ( 4 ) 頁： 593 2022年4月

An Empirical Study on the Use of Visual Explanation in Kidney Cancer Detection

Takahashi, M; Kameya, Y; Yamada, K; Hotta, K; Takahashi, T; Sassa, N; Iwano, S; Yamamoto, T

TWELFTH INTERNATIONAL CONFERENCE ON DIGITAL IMAGE PROCESSING (ICDIP 2020) 11519 巻 2020年

Does I-131 uptake in the subhyoid portion or lymph nodes affect the outcome of low-dose ablation therapy for patients with differentiated thyroid cancer?

Ito, S; Iwano, S; Kato, K; Naganawa, S

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 46 巻 ( SUPPL 1 ) 頁： S662 - S663 2019年10月

Impact of Combined Evaluation Using Tumor Volume and Metastatic Nodal Extent in Stage III NSCLC Treated with CRT

Tamiya, Y; Morise, M; Matsuzawa, R; Tanaka, I; Okada, T; Iwano, S; Hase, T; Hashimoto, N; Sato, M; Itoh, Y; Hasegawa, Y

JOURNAL OF THORACIC ONCOLOGY 14 巻 ( 10 ) 頁： S909 - S910 2019年10月

Postoperative recurrence of clinical early-stage non-small cell lung cancers: a comparison between solid and subsolid nodules

Iwano, S; Umakoshi, H; Kamiya, S; Yokoi, K; Kawaguchi, K; Fukui, T; Naganawa, S

CANCER IMAGING 19 巻 ( 1 ) 頁： 33 2019年6月

Evaluation of intra-tumoral blood feeding to predict the effect of induction therapy in patients with locally advanced lung cancer

Kawaguchi, K; Fukui, T; Goto, M; Nakamura, S; Hakiri, S; Ozeki, N; Kato, T; Mori, S; Hashimoto, K; Iwano, S; Yokoi, K

NAGOYA JOURNAL OF MEDICAL SCIENCE 81 巻 ( 2 ) 頁： 291 - 301 2019年5月

Prediction of recurrence using volume-based metabolic index obtained by preoperative FDG-PET for non-small-cell lung cancer

Ito, S; Iwano, S; Kato, K; Naganawa, S

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 45 巻頁： S506 - S506 2018年10月

Dense volumetric detection and segmentation of mediastinal lymph nodes in chest CT images

Oda, H; Roth, HR; Bhatia, KK; Oda, M; Kitasaka, T; Iwano, S; Homma, H; Takabatake, H; Mori, M; Natori, H; Schnabel, JA; Mori, K

MEDICAL IMAGING 2018: COMPUTER-AIDED DIAGNOSIS 10575 巻 2018年

Risk Factor Evaluation of Programmed Death 1 Inhibitor Related Pneumonitis in Patients with Non-Small Cell Lung Cancer

Fukihara, J; Sakamoto, K; Iwano, S; Morise, M; Hashimoto, N; Hasegawa, Y

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 197 巻 2018年

Diagnostic utility of chest wall vessel involvement sign on ultra-high-resolution CT for primary lung cancer infiltrating the chest wall 国際誌 Open Access

Uota, F; Iwano, S; Kamiya, S; Ito, R; Nakamura, S; Chen-Yoshikawa, TF; Naganawa, S

EUROPEAN RADIOLOGY 2025年1月

Measurement of solid size in early-stage lung adenocarcinoma by virtual 3D thin-section CT applied artificial intelligence 国際誌 Open Access

Iwano, S; Kamiya, S; Ito, R; Kudo, A; Kitamura, Y; Nakamura, K; Naganawa, S

SCIENTIFIC REPORTS 13 巻 ( 1 ) 頁： 21709 - 21709 2023年12月

Prognostic impact of highly solid component in early-stage solid lung adenocarcinoma 査読有り国際誌

Kato, T; Iwano, S; Hanamatsu, Y; Nakaguro, M; Emoto, R; Okado, S; Sato, K; Noritake, O; Nakanishi, K; Kadomatsu, Y; Ueno, H; Ozeki, N; Nakamura, S; Fukumoto, K; Takeuchi, T; Karube, K; Matsui, S; Chen-Yoshikawa, TF

QUANTITATIVE IMAGING IN MEDICINE AND SURGERY 13 巻 ( 9 ) 頁： 5641 - + 2023年9月

Virtual Bronchoscopy-Guided Transbronchial Biopsy Simulation Using a Head-Mounted Display: A New Style of Flexible Bronchoscopy 査読有り国際誌

Okachi, S; Ito, T; Sato, K; Iwano, S; Shinohara, Y; Itoigawa, H; Hashimoto, N

SURGICAL INNOVATION 29 巻 ( 6 ) 頁： 811 - 813 2022年12月

Diagnostic value and safety of endobronchial ultrasonography with a guide sheath transbronchial biopsy for diagnosing peripheral pulmonary lesions in patients with interstitial lung disease 査読有り国際誌

Ito, T; Okachi, S; Iwano, S; Kinoshita, F; Wakahara, K; Hashimoto, N; Chen-Yoshikawa, TF

JOURNAL OF THORACIC DISEASE 14 巻 ( 11 ) 頁： 4361 - 4371 2022年11月

Chest three-dimensional-computed tomography imaging data analysis for the variation of exercise capacity after lung lobectomy 査読有り国際誌

Ozeki, N; Iwano, S; Nakamura, S; Kawaguchi, K; Mizuno, Y; Inoue, T; Nagaya, M; Chen-Yoshikawa, TF

CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING 42 巻 ( 5 ) 頁： 362 - 371 2022年9月

人工知能を応用したバーチャル3D thin-section CTを用いた肺腺癌の充実成分径の計測

岩野信吾, 神谷晋一朗, 伊藤倫太郎, 工藤彰, 北村嘉郎, 中村圭児, 長縄慎二

断層映像研究会雑誌 49 巻 ( 2 ) 頁： 39 - 39 2022年9月

Features from MRI texture analysis associated with survival outcomes in triple-negative breast cancer patients 査読有り

Kamiya, S; Satake, H; Hayashi, Y; Ishigaki, S; Ito, R; Kawamura, M; Taoka, T; Iwano, S; Naganawa, S

BREAST CANCER 29 巻 ( 1 ) 頁： 164 - 173 2022年1月

Incidental findings on computed tomography for preoperative assessment before transcatheter aortic valve implantation in Japanese patients 査読有り

Tobe, A; Tanaka, A; Tokuda, Y; Miki, Y; Furusawa, K; Akita, S; Fujii, T; Tsutsumi, Y; Ishii, H; Iwano, S; Naganawa, S; Usui, A; Murohara, T

HEART AND VESSELS 36 巻 ( 12 ) 頁： 1911 - 1922 2021年12月

Diagnostic utility of metabolic parameters on FDG PET/CT for lymph node metastasis in patients with cN2 non-small cell lung cancer 査読有り国際誌

Nakanishi, K; Nakamura, S; Sugiyama, T; Kadomatsu, Y; Ueno, H; Goto, M; Ozeki, N; Fukui, T; Iwano, S; Chen-Yoshikawa, TF

BMC CANCER 21 巻 ( 1 ) 頁： 983 - 983 2021年9月

【COVID-19肺炎と肺疾患AI開発のフロントライン】COVID-19肺炎におけるAI研究の動向および問題点について

伊藤倫太郎, 岩野信吾, 長縄慎二

医用画像情報学会雑誌 38 巻 ( 2 ) 頁： 32 - 40 2021年7月

記述言語：日本語出版者・発行元：医用画像情報学会

COVID-19が世界中に広まり、COVID-19肺炎の診断に胸部CTや胸部単純X線の有用性が報告され、この画像所見を用いたAI開発が初期の段階から積極的に行われた。高性能なAIが多数存在するが、臨床において用いる際には注意すべき点が複数存在する。COVID-19肺炎に対して開発・使用された画像診断に関連するAI研究について、PubMedに2020年12月までに登録されたものを抽出しレビューを行った。

cN2非小細胞肺癌のリンパ節転移に対するFDG PET/CTでの代謝パラメーターの診断的有用性に関する検討

仲西慶太, 矢澤まり, 坪内秀樹, 杉山燈人, 門松由佳, 上野陽史, 後藤真輝, 尾関直樹, 中村彰太, 福井高幸, 岩野信吾, 芳川豊史

日本外科学会定期学術集会抄録集 121回巻頁： PS - 8 2021年4月

Factors associated with changes in the 12-m stair-climbing time after lung lobectomy 査読有り

Ozeki, N; Fukui, T; Iwano, S; Hakiri, S; Nakamura, S; Kawaguchi, K; Mizuno, Y; Inoue, T; Nagaya, M; Chen-Yoshikawa, TFS

GENERAL THORACIC AND CARDIOVASCULAR SURGERY 69 巻 ( 2 ) 頁： 282 - 289 2021年2月

Iwano, S; Kamiya, S; Ito, R; Nakamura, S; Naganawa, S

CANCER IMAGING 21 巻 ( 1 ) 頁： 7 - 7 2021年1月

A review on the use of artificial intelligence for medical imaging of the lungs of patients with coronavirus disease 2019 国際誌

Ito, R; Iwano, S; Naganawa, S

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY 26 巻 ( 5 ) 頁： 443 - 448 2020年9月

Bronchial wall thickening is associated with severity of chronic rhinosinusitis

Majima, S; Wakahara, K; Nishio, T; Nishio, N; Teranishi, M; Iwano, S; Hirakawa, A; Hashimoto, N; Sone, M; Hasegawa, Y

RESPIRATORY MEDICINE 170 巻頁： 106024 2020年8月

Assessment of Severity in Chronic Thromboembolic Pulmonary Hypertension by Quantitative Parameters of Dual-Energy Computed Tomography 国際誌

Tsutsumi, Y; Iwano, S; Okumura, N; Adachi, S; Abe, S; Kondo, T; Kato, K; Naganawa, S

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 44 巻 ( 4 ) 頁： 578 - 585 2020年7月

Well-differentiated fetal adenocarcinoma of the lung: positron emission tomography features and diagnostic difficulties in frozen section analysis-a case report 国際誌

Hakiri, S; Fukui, T; Tsubouchi, H; Sakakibara, A; Iwano, S; Chen-Yoshikawa, TF

SURGICAL CASE REPORTS 6 巻 ( 1 ) 頁： 152 - 152 2020年6月

Psoas muscle mass in patients undergoing lung cancer surgery: a prognostic difference between squamous cell carcinoma and adenocarcinoma 査読有り

Ozeki, N; Kawaguchi, K; Fukui, T; Nakamura, S; Hakiri, S; Mori, S; Goto, M; Iwano, S; Yokoi, K; Chen-Yoshikawa, TF

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 25 巻 ( 5 ) 頁： 876 - 884 2020年5月

Unexpected radioactive iodine accumulation on whole-body scan after I-131 ablation therapy for differentiated thyroid cancer

Iwano, S; Ito, S; Kamiya, S; Ito, R; Kato, K; Naganawa, S

NAGOYA JOURNAL OF MEDICAL SCIENCE 82 巻 ( 2 ) 頁： 205 - 215 2020年5月

Reply to "Prognostic Impact and Risk Factors of Immune-Related Pneumonitis in Patients With NoneSmall-Cell Lung Cancer Who Received Programmed Death-1 Inhibitors" 国際誌

Fukihara, J; Sakamoto, K; Koyama, J; Ito, T; Iwano, S; Morise, M; Ogawa, M; Kondoh, Y; Kimura, T; Hashimoto, N; Hasegawa, Y

CLINICAL LUNG CANCER 21 巻 ( 3 ) 頁： E205 - E205 2020年5月

病期Iの肺癌切除症例の術後再発における残存慢性呼吸器疾患の影響に関する検討

橋本直純, 川口晃司, 岩野信吾

肺癌 60 巻 ( 2 ) 頁： 143 - 143 2020年4月

【基礎から学ぶ肺癌診断】肺癌の3次元CT・PET/CT診断原発巣の診断と悪性度

岩野信吾, 伊藤信嗣, 伊藤倫太郎, 神谷晋一朗, 加藤克彦, 長縄慎二

画像診断 40 巻 ( 5 ) 頁： 439 - 446 2020年3月

記述言語：日本語出版者・発行元：(株)Gakken

＜文献概要＞肺癌の臨床病期分類(TNM分類)は主に画像診断に基づいて行われる.2017年に改訂されたTNM分類では,T因子(サイズ)の診断が複雑になった.病理学的浸潤径に相当する充実成分径の計測はthinsection CTで行うのが基本であるが,3次元CTやPET/CTを利用することで精度の向上が期待できる.

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00235&link_issn=&doc_id=20200408090014&doc_link_id=10.15105%2FGZ.0000001656&url=https%3A%2F%2Fdoi.org%2F10.15105%2FGZ.0000001656&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Micro-computed tomography images of lung adenocarcinoma: detection of lepidic growth patterns 査読有り

Nakamura, S; Mori, K; Iwano, S; Kawaguchi, K; Fukui, T; Hakiri, S; Ozeki, N; Oda, M; Yokoi, K

NAGOYA JOURNAL OF MEDICAL SCIENCE 82 巻 ( 1 ) 頁： 25 - 31 2020年2月

中枢神経系原発anaplastic lymphoma kinase陽性未分化大細胞リンパ腫の1例

佐々木裕太郎, 中道玲瑛, 伊藤信嗣, 川井恒, 岩野信吾, 田岡俊昭, 加藤克彦, 川島直美, 下山芳江, 長縄慎二

映像情報Medical 52 巻 ( 1 ) 頁： 82 - 83 2020年1月

Kinetic volume analysis on dynamic contrast-enhanced MRI of triple-negative breast cancer: associations with survival outcomes 査読有り国際誌

Hayashi, Y; Satake, H; Ishigaki, S; Ito, R; Kawamura, M; Kawai, H; Iwano, S; Naganawa, S

BRITISH JOURNAL OF RADIOLOGY 93 巻 ( 1106 ) 頁： 20190712 - 20190712 2020年

Prognostic Impact and Risk Factors of Immune-Related Pneumonitis in Patients With Non-Small-Cell Lung Cancer Who Received Programmed Death 1 Inhibitors 国際誌

Fukihara, J; Sakamoto, K; Koyama, J; Ito, T; Iwano, S; Morise, M; Ogawa, M; Kondoh, Y; Kimura, T; Hashimoto, N; Hasegawa, Y

CLINICAL LUNG CANCER 20 巻 ( 6 ) 頁： 442 - + 2019年11月

ディープラーニングを用いた胸部CT像中の肺結節の画像所見の検出および良悪性鑑別

福嶋一茂, 平野靖, 木戸尚治, 岩野信吾

MEDICAL IMAGING TECHNOLOGY 37 巻 ( 5 ) 頁： 244 - 253 2019年11月

記述言語：日本語出版者・発行元：日本医用画像工学会

近年、コンピューター診断支援(computer-aided diagnosis;CADx)システムに関する研究では、ディープラーニングが使用される機会が多くなってきており、従来よりも高い性能を示すことが報告されている。肺結節の良悪性鑑別のためのCADxシステムでも同様の傾向があるが、それらはCT像などを入力とし、良性あるいは悪性の尤度のみを出力するか、クラス分類するものが一般的である。一方で、患者に対して医師が肺結節の診断結果を説明する際には、良悪性の尤度だけでは不十分であり、診断結果の根拠を説明することが求められる。そこで本研究ではディープラーニングの一形態であるCNN(convolutional neural network)を用いて、CT像中の肺結節が悪性であることを示唆する画像所見の存在の尤度を診断の根拠として提供し、さらにそれらの尤度を入力するNN(neural network)によって良悪性の鑑別結果を医師に提供するCADxシステムの構築を行った。55個の良性結節と120個の悪性結節を用いて本手法の性能を評価した結果、識別率は79.02±8.43[%]となった。(著者抄録)

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J02087&link_issn=&doc_id=20200115200004&doc_link_id=%2Fen9meite%2F2019%2F003705%2F004%2F0244-0254%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fen9meite%2F2019%2F003705%2F004%2F0244-0254%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Multi-window levels and widths imaging 画像変換による新たな読影手法の検討

伊藤倫太郎, 岩野信吾, 小田紘久, 森健策, 長縄慎二

日本医学放射線学会秋季臨床大会抄録集 55回巻頁： S531 - S532 2019年9月

Renewed Japanese spirometric reference variables and risk stratification for postoperative outcomes in COPD patients with resected lung cancer

Okada, Y; Hashimoto, N; Iwano, S; Kawaguchi, K; Fukui, T; Sakamoto, K; Wakai, K; Yokoi, K; Hasegawa, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE 81 巻 ( 3 ) 頁： 427 - 438 2019年8月

Utility of Metabolic Parameters on FDG PET/CT in the Classification of Early-Stage Lung Adenocarcinoma Prediction of Pathological Invasive Size 査読有り国際誌

Iwano, S; Ito, S; Kamiya, S; Ito, R; Kato, K; Naganawa, S

CLINICAL NUCLEAR MEDICINE 44 巻 ( 7 ) 頁： 560 - 565 2019年7月

【人工知能が医療を変える!医療分野におけるAI研究開発最前線2019】領域別・画像診断におけるAI研究開発の最前線胸部領域胸部画像診断におけるAIと臨床研究について

伊藤倫太郎, 岩野信吾, 長縄慎二

INNERVISION 34 巻 ( 7 ) 頁： 25 - 28 2019年6月

記述言語：日本語出版者・発行元：(株)インナービジョン

2006年から始まった第三次AIブームによりAIの研究が加速度的に進み、現在ではスマートフォンのカメラや音声入力など身近なものに活用されている。放射線医学においては古くから人工知能(AI)を用いた研究が行われ、臨床にも応用されていた。最近では、さらに発展したAIを用いたCADの開発が盛んであり、世界中の研究者が開発を競っている。本稿では、加速度的に進歩するAIと放射線医学とのかかわりについて、主に胸部画像診断の観点から現在の状況と問題点についてまとめ、実際の研究例について提示する。(著者抄録)

画像診断と病理食道平滑筋腫

兵藤良太, 岩野信吾, 長縄慎二, 宮田一志, 島田聡子

画像診断 39 巻 ( 7 ) 頁： 662 - 663 2019年5月

Association between chest computed tomography findings and respiratory adverse events in rheumatoid arthritis patients undergoing long-term biological therapy 査読有り

Matsumoto, T; Iwano, S; Takahashi, N; Asai, S; Watanabe, T; Asai, N; Sobue, Y; Ito, S; Ishiguro, N; Kojima, T

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 22 巻 ( 4 ) 頁： 626 - 635 2019年4月

FDG-PET/CTの腫瘍代謝容積に基づいた肺腺癌の臨床病期診断の試み

岩野信吾, 伊藤倫太郎, 長縄慎二

肺癌 59 巻 ( 2 ) 頁： 189 - 189 2019年4月

Longitudinal changes in pulmonary function and respiratory impedance of rheumatoid arthritis 査読有り

Isobe, Y; Ito, S; Matsuda, T; Iwano, S; Uchida, A; Takahashi, N; Kojima, T; Wakahara, K; Yamaguchi, E; Hasegawa, Y

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY 261 巻頁： 1 - 8 2019年3月

Quantitative Follow-Up Assessment of Patients with Interstitial Lung Disease by 3D-Curved High-Resolution CT Imaging Parallel to the Chest Wall 査読有り

Umakoshi, H; Iwano, S; Inoue, T; Li, YZ; Nakamura, K; Naganawa, S

NAGOYA JOURNAL OF MEDICAL SCIENCE 81 巻 ( 1 ) 頁： 41 - 53 2019年2月

原発性肺癌の術前臨床病期診断の正確性

岩野信吾, 馬越弘泰, 伊藤倫太郎, 島本宏矩, 長縄慎二

Japanese Journal of Radiology 37 巻 ( Suppl. ) 頁： 25 - 25 2019年2月

Effect of blood glucose level on standardized uptake value (SUV) in <SUP>18</SUP>F- FDG PET-scan: a systematic review and meta-analysis of 20,807 individual SUV measurements 査読有り

Eskian, M; Alavi, A; Khorasanizadeh, M; Viglianti, BL; Jacobsson, H; Barwick, TD; Meysamie, A; Yi, SK; Iwano, S; Bybel, B; Caobelli, F; Lococo, F; Gea, J; Sancho-Muñoz, A; Schildt, J; Tatci, E; Lapa, C; Keramida, G; Peters, M; Boktor, RR; John, J; Pitman, AG; Mazurek, T; Rezaei, N

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 46 巻 ( 1 ) 頁： 224 - 237 2019年1月

ディープラーニングを用いた胸部CT像中の肺結節の画像所見の検出および良悪性鑑別

福嶋一茂, 平野靖, 木戸尚治, 岩野信吾

ＭｅｄｉｃａｌＩｍａｇｉｎｇＴｅｃｈｎｏｌｏｇｙ 37 巻 ( 5 ) 頁： 244 - 254 2019年

記述言語：日本語出版者・発行元：日本医用画像工学会

<p>近年，コンピューター診断支援（computer-aided diagnosis; CADx）システムに関する研究では，ディープラーニングが使用される機会が多くなってきており，従来よりも高い性能を示すことが報告されている．肺結節の良悪性鑑別のためのCADxシステムでも同様の傾向があるが，それらはCT像などを入力とし，良性あるいは悪性の尤度のみを出力するか，クラス分類するものが一般的である．一方で，患者に対して医師が肺結節の診断結果を説明する際には，良悪性の尤度だけでは不十分であり，診断結果の根拠を説明することが求められる．そこで本研究ではディープラーニングの一形態であるCNN（convolutional neural network）を用いて，CT像中の肺結節が悪性であることを示唆する画像所見の存在の尤度を診断の根拠として提供し，さらにそれらの尤度を入力とするNN（neural network）によって良悪性の鑑別結果を医師に提供するCADxシステムの構築を行った．55個の良性結節と120個の悪性結節を用いて本手法の性能を評価した結果，識別率は79.02±8.43［％］となった．</p>

DOI： 10.11409/mit.37.244

Generative Adversarial Networkを用いた肺結節の画像生成について

伊藤倫太郎, 岩野信吾, 長縄慎二

日本医学放射線学会秋季臨床大会抄録集 54回巻頁： S561 - S561 2018年9月

Impact of Patient Age and Histological Type on Radioactive Iodine Avidity of Recurrent Lesions of Differentiated Thyroid Carcinoma 査読有り

Nakanishi, K; Kikumori, T; Miyajima, N; Takano, Y; Noda, S; Takeuchi, D; Iwano, S; Kodera, Y

CLINICAL NUCLEAR MEDICINE 43 巻 ( 7 ) 頁： 482 - 485 2018年7月

Deep Learningを用いた胸部CT像中の肺結節の画像所見の検出および良悪性鑑別

福嶋一茂, 平野靖, 木戸尚治, 岩野信吾

日本医用画像工学会大会予稿集 37回巻頁： 173 - 181 2018年7月

記述言語：日本語出版者・発行元：日本医用画像工学会

近年、コンピュータ診断支援(Computer-Aided Diagnosis,CADx)システムに関する研究では、Deep Learningが使用される機会が多くなってきており、従来よりも高い性能を示すことが報告されている。肺結節の良悪性鑑別のためのCADxシステムでも同様の傾向があるが、それらはCT像等を入力とし、良性あるいは悪性の尤度のみを出力するか、クラス分類するものが一般的である。一方で患者に対して医師が肺結節の診断結果を説明する際には、良悪性の尤度だけでは不十分であり、診断結果の根拠を説明することが求められる。そこで本研究ではDeep Learningの一形態であるCNN(Convolutional Neural Network)を用いて、CT像中の肺結節が悪性であることを示唆する画像所見の存在の尤度を診断の根拠として提供し、さらにそれらの尤度を入力とするNN(Neural Network)によって良悪性の鑑別結果を医師に提供するCADxシステムの構築を行った。55個の良性結節と120個の悪性結節を用いて本手法の性能を評価した結果、識別率は79.02±8.43[%]となった。(著者抄録)

Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer 査読有り

Ito, S; Iwano, S; Kato, K; Naganawa, S

ANNALS OF NUCLEAR MEDICINE 32 巻 ( 6 ) 頁： 418 - 424 2018年7月

Computer-aided Volumetry of Part-Solid Lung Cancers by Using CT: Solid Component Size Predicts Prognosis 査読有り国際誌

Kamiya, S; Iwano, S; Umakoshi, H; Ito, R; Shimamoto, H; Nakamura, S; Naganawa, S

RADIOLOGY 287 巻 ( 3 ) 頁： 1030 - 1040 2018年6月

胸壁並行断面CTを用いた間質性肺炎の経時的評価

馬越弘泰, 岩野信吾, 伊藤倫太郎, 島本宏矩, 長縄慎二

Japanese Journal of Radiology 36 巻 ( Suppl. ) 頁： 19 - 19 2018年2月

非小細胞肺癌の局所浸潤性の予測に関する造影dual energy CTとFDG-PET/CTの比較

伊藤倫太郎, 岩野信吾, 島本宏矩, 馬越弘泰, 伊藤信嗣, 長縄慎二, 加藤克彦

Japanese Journal of Radiology 36 巻 ( Suppl. ) 頁： 20 - 20 2018年2月

Thin-section computed tomography-determined usual interstitial pneumonia pattern affects the decision-making process for resection in newly diagnosed lung cancer patients: a retrospective study 査読有り

Hashimoto, N; Ando, A; Iwano, S; Sakamoto, K; Okachi, S; Matsuzaki, A; Okada, Y; Wakai, K; Yokoi, K; Hasegawa, Y

BMC PULMONARY MEDICINE 18 巻 ( 1 ) 頁： 2 2018年1月

FDG PET/CT Overcomes Discordance Between Clinical and Pathologic TNM Classification of Small-size Primary Lung Cancer: Influence on Postoperative Prognosis 査読有り国際誌

Umakoshi, H; Iwano, S; Yokoi, K; Ito, S; Ito, R; Kawaguchi, K; Fukui, T; Naganawa, S

CLINICAL LUNG CANCER 19 巻 ( 1 ) 頁： E37 - E45 2018年1月

A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological invasiveness of non-small cell lung cancer 査読有り国際誌

Ito, R; Iwano, S; Shimamoto, H; Umakoshi, H; Kawaguchi, K; Ito, S; Kato, K; Naganawa, S

EUROPEAN JOURNAL OF RADIOLOGY 95 巻頁： 186 - 191 2017年10月

Automated mediastinal lymph node detection from CT volumes based on intensity targeted radial structure tensor analysis. 査読有り

Oda H, Bhatia KK, Oda M, Kitasaka T, Iwano S, Homma H, Takabatake H, Mori M, Natori H, Schnabel JA, Mori K

Journal of medical imaging (Bellingham, Wash.) 4 巻 ( 4 ) 頁： 044502 2017年10月

Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall: A pilot study 査読有り国際誌

Umakoshi, H; Iwano, S; Inoue, T; Li, YZ; Naganawa, S

PLOS ONE 12 巻 ( 9 ) 頁： e0185532 2017年9月

Dual Energy CTによる小型肺癌の造影評価

島本宏矩, 岩野信吾, 馬越弘泰, 伊藤倫太郎, 長縄慎二

Japanese Journal of Radiology 35 巻 ( Suppl. ) 頁： 34 - 34 2017年2月

胸壁並行断面CTを用いた間質性肺炎の定量的評価

馬越弘泰, 岩野信吾, 伊藤倫太郎, 長縄慎二

Japanese Journal of Radiology 35 巻 ( Suppl. ) 頁： 34 - 34 2017年2月

ドパミントランスポータシンチグラフィにおける解析ソフトの有用性に関する研究

松澤伸一郎, 加藤克彦, 国本啓太, 本田将之, 椋本竜斗, 小田川哲郎, 阿部真治, 藤田尚利, 櫻木庸博, 伊藤信嗣, 伊藤倫太郎, 岩野信吾, 長縄慎二

核医学 54 巻 ( 1 ) 頁： 663 - 663 2017年2月

FDG-PETによる非小細胞肺癌の予後予測因子の検討 SUVmaxと体積を考慮した指標の比較

伊藤信嗣, 岩野信吾, 伊藤倫太郎, 長縄慎二, 加藤克彦

核医学 54 巻 ( 1 ) 頁： 565 - 565 2017年2月

Thoracic Temporal Subtraction Three Dimensional Computed Tomography (3D-CT): Screening for Vertebral Metastases of Primary Lung Cancers 査読有り国際誌

Iwano, S; Ito, R; Umakoshi, H; Karino, T; Inoue, T; Li, YZ; Naganawa, S

PLOS ONE 12 巻 ( 1 ) 頁： e0170309 2017年1月

Hessian-Assisted Supervoxel: Structure-Oriented Voxel Clustering and Application to Mediastinal Lymph Node Detection from CT Volumes 査読有り

Oda, H; Bhatia, KK; Oda, M; Kitasaka, T; Iwano, S; Homma, H; Takabatake, H; Mori, M; Natori, H; Schnabel, JA; Mori, K

MEDICAL IMAGING 2017: COMPUTER-AIDED DIAGNOSIS 10134 巻 2017年

Planning video-assisted thoracic surgery segmentectomy using three dimensional computed tomography angiography and bronchography with a virtual safety margin. 査読有り

Iwano S

Journal of visualized surgery 3 巻頁： 82 2017年

Visualization of Middle Ear Ossicles in Elder Subjects with Ultra-short Echo Time MR Imaging 査読有り

Naganawa, S; Nakane, T; Kawai, H; Taoka, T; Suzuki, K; Iwano, S; Satake, H; Grodzki, D

MAGNETIC RESONANCE IN MEDICAL SCIENCES 16 巻 ( 2 ) 頁： 93 - 97 2017年

Evaluation of locoregional invasiveness of small-sized non-small cell lung cancers by enhanced dual-energy computed tomography 査読有り

Shimamoto H, Iwano S, Umakoshi H, Kawaguchi K, Naganawa S

Cancer Imaging 16 巻 ( 1 ) 頁： 18 2016年7月

Respiratory mechanics measured by forced oscillation technique in rheumatoid arthritis-related pulmonary abnormalities: frequency-dependence, heterogeneity and effects of smoking 査読有り

Sokai R, Ito S, Iwano S, Uchida A, Aso H, Kondo M, Ishiguro N, Kojima T, Hasegawa, Y

Springerplus 5 巻頁： 335 2016年4月

Correlation between FDG-PET/CT findings and solid type non-small cell cancer prognostic factors: are there differences between adenocarcinoma and squamous cell carcinoma? 査読有り

Ito R, Iwano S, Kishimoto M, Ito S, Kato K, Naganawa S.

Ann Nucl Med 29 巻 ( 10 ) 頁： 897-905 2015年9月

Evaluation of lung cancer by enhanced dual-energy CT: Association between three-dimensional iodine concentration and tumor differentiation. 査読有り

Iwano S, Ito R, Umakoshi H, Ito S, Naganawa S

Br J Radiol 88 巻頁： 20150224 2015年9月

The contact length between the tumor contour and the lung on computed tomography is a risk factor for pleural recurrence after complete resection of thymoma. 査読有り

Kato T, Iwano S, Taniguchi T, Kawaguchi K, Fukui T, Ishiguro F, Fukumoto K, Nakamura S, Hirakawa A, Yokoi K.

Gen Thorac Cardiovasc Surg 63 巻 ( 6 ) 頁： 343-348 2015年2月

Evaluation of emphysema using three-dimensional computed tomography: association with postoperative complications in lung cancer patients 査読有り

Kawakami K, Iwano S, Hashimoto N, Hasegawa Y, Naganawa S.

Nagoya J Med Sci 77 巻 ( 1-2 ) 頁： 113-122 2015年2月

Lobar analysis of collapsibility indices to assess functional lung volumes in COPD patients. 査読有り

Kitano M, Iwano S, Hashimoto N, Matsuo K, Hasegawa Y, Naganawa S.

Int J Chron Obstruct Pulmon Dis. 9 巻頁： 1347-1356 2014年12月

Prognostic evaluations of small size lung cancers by 18F-FDG PET/CT and thin-section CT. 査読有り

Kishimoto M, Iwano S, Ito S, Kato K, Ito R, Naganawa S

Lung Cancer 86 巻 ( 2 ) 頁： 180-184 2014年9月

Evaluation of 11C-choline PET/CT for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract: a pilot study. 査読有り

Sassa N, Kato K, Abe S, Iwano S, Ito S, Ikeda M, Shimamoto K, Yamamoto S, Yamamoto T, Gotoh M, Naganawa S.

Eur J Nucl Med Mol Imaging 41 巻 ( 12 ) 頁： 2232-2241 2014年8月

Therapeutic surgery without a definitive diagnosis can be an option in selected patients with suspected lung cancer. 査読有り

Ozeki N, Iwano S, Taniguchi T, Kawaguchi K, Fukui T, Ishiguro F, Fukumoto K, Nakamura S, Hirakawa A, Yokoi K.

Interact Cardiovasc Thorac Surg 19 巻 ( 5 ) 頁： 830-837 2014年7月

Prediction of pathologic prognostic factors in patients with lung adenocarcinomas: comparison of thin-section computed tomography and positron emission tomography/computed tomography. 査読有り

Iwano S, Kishimoto M, Ito S, Kato K, Ito R, Naganawa S

Cancer Imaging 22 巻 ( 14 ) 頁： 3 2014年4月

Clinical impact of prevalence and severity of COPD on the decision-making process for therapeutic management of lung cancer patients. 査読有り

Hashimoto N, Matsuzaki A, Okada Y, Imai N, Iwano S, Wakai K, Imaizumi K, Yokoi K, Hasegawa Y

BMC Pulm Med 5 巻 ( 14 ) 頁： 14 2014年2月

Comparison of 18F-fluoride PET/CT, 18F-FDG PET/CT and bone scintigraphy (planar and SPECT) in detection of bone metastases of differentiated thyroid cancer: a pilot study. 査読有り

Ota N, Kato K, Iwano S, Ito S, Abe S, Fujita N, Yamashiro K, Yamamoto S, Naganawa S.

Br J Radiol 87 巻 ( 1034 ) 頁： 20130444 2014年1月

Doubling time calculations for lung cancer by three-dimensional computer-aided volumetry: effects of inter-observer differences and nodule characteristics 査読有り

Koike, W. Iwano, S. Matsuo, K. Kitano, M. Kawakami, K. Naganawa, S.

J Med Imaging Radiat Oncol 58 巻 ( 1 ) 頁： 82-8 2013年10月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: The purpose of this study was to investigate doubling time (DT) differences among solid, part-solid (PS) and non-solid (NS) types of lung cancers. We also compared inter-observer differences in size measurements between diameter and three-dimensional (3D) volume measurements of lung cancers, including PS- and NS-type nodules, using 3D computer-aided volumetry (3D-CAV). METHODS: The long-axis diameters and 3D volumes of lung tumours were measured using CAV by two chest radiologists for 71 consecutive patients with peripheral lung cancer who underwent at least two CT examinations before surgical resection. We evaluated the inter-observer variability for the ratio of diameter change (RCdiameter) and volume change (RCvolume), which were based on two CT images obtained at different times prior to resection. Inter-observer agreement was evaluated by Bland-Altman plots. Based on the volumes obtained from 3D-CAV, we calculated the DTs and compared DT differences between solid, PS and NS types of lung tumours. RESULTS: The inter-observer Spearman's rank correlation coefficients were 0.87 for RCvolume and 0.64 for RCdiameter (p < 0.001). For all internal appearance types, the rs values for RCvolume were greater than those for RCdiameter. The median DT values for solid, PS and NS were 278, 347 and 584 days, respectively. NS- and PS-type tumours had significantly longer DTs (p = 0.024; by Spearman's rank correlation coefficient). CONCLUSIONS: DT determinations using 3D-CAV had good correlations with the internal appearances of lung cancers. Lung tumour volume measurements by 3D-CAV exhibited better inter-observer correlations than did diameter measurements.

DOI： 10.1111/1754-9485.12128

PubMed

Planning of segmentectomy using three-dimensional computed tomography angiography with a virtual safety margin: technique and initial experience. 査読有り

Iwano S, Yokoi K, Taniguchi T, Kawaguchi K, Fukui T, Naganawa S

Lung Cancer 81 巻 ( 3 ) 頁： 410-415 2013年7月

Limited efficacy of (18)F-FDG PET/CT for differentiation between metastasis-free pancreatic cancer and mass-forming pancreatitis. 査読有り

Kato K, Nihashi T, Ikeda M, Abe S, Iwano S, Itoh S, Shimamoto K, Naganawa S

Clinical nuclear medicine 38 巻 ( 6 ) 頁： 417-21 2013年6月

Pulmonary lobar volumetry using novel volumetric computer-aided diagnosis and computed tomography 査読有り

Iwano S, Kitano M, Matsuo K, Kawakami K, Koike W, Kishimoto M, Inoue T, Li Y, Naganawa S

Interact Cardiovasc Thorac Surg 17 巻 ( 1 ) 頁： 59-65 2013年3月

What causes false-negative PET findings for solid-type lung cancer? 査読有り

Iwano S, Ito S, Tsuchiya K, Kato K, Naganawa S

Lung cancer (Amsterdam, Netherlands) 79 巻 ( 2 ) 頁： 132-6 2013年2月

Supplemental value of diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) technique to whole-body magnetic resonance imaging in detection of bone metastases from thyroid cancer. 査読有り

Sakurai Y, Kawai H, Iwano S, Ito S, Ogawa H, Naganawa S

J Med Imaging Radiat Oncol 57 巻 ( 3 ) 頁： 297-305 2012年12月

An anomalous segmental vein of the left upper lobe of the lung: preoperative identification by three-dimensional computed tomography pulmonary angiography. 査読有り

Ishikawa Y, Iwano S, Usami N, Yokoi K

Interactive cardiovascular and thoracic surgery 15 巻 ( 3 ) 頁： 512-3 2012年9月

Correlation between dynamic CT findings and pathological prognostic factors of small lung adenocarcinoma. 査読有り

Iwano S, Koike W, Matsuo K, Kitano M, Kawakami K, Okada T, Naganawa S

Cancer imaging : the official publication of the International Cancer Imaging Society 12 巻頁： 187-93 2012年6月

3D-CT lung volumetry using multidetector row computed tomography: pulmonary function of each anatomic lobe. 査読有り

Matsuo K, Iwano S, Okada T, Koike W, Naganawa S

Journal of thoracic imaging 27 巻 ( 3 ) 頁： 164-70 2012年5月

FDG-PET performed concurrently with initial I-131 ablation for differentiated thyroid cancer. 査読有り

Iwano S, Kato K, Ito S, Tsuchiya K, Naganawa S

Annals of nuclear medicine 26 巻 ( 3 ) 頁： 207-13 2012年4月

Mediastinal atlas creation from 3-D chest computed tomography images: application to automated detection and station mapping of lymph nodes. 査読有り

Feuerstein M, Glocker B, Kitasaka T, Nakamura Y, Iwano S, Mori K

Medical image analysis 16 巻 ( 1 ) 頁： 63-74 2012年1月

Correlation between dual-phase dynamic multi-detector CT findings and fibrosis within lung adenocarcinoma tumors. 査読有り

Iwano S, Koike W, Matsuo K, Okada T, Shimoyama Y, Naganawa S

European journal of radiology 80 巻 ( 3 ) 頁： e470-5 2011年12月

*Virtual bronchoscopy-guided transbronchial biopsy for aiding the diagnosis of peripheral lung cancer. 査読有り

Iwano S, Imaizumi K, Okada T, Hasegawa Y, Naganawa S.

Eur J Radiol 79 巻 ( 1 ) 頁： 155-159 2011年7月

Diagnostic value of SPIO-mediated breath-hold, black-blood, fluid-attenuated, inversion recovery (BH-BB-FLAIR) imaging in patients with hepatocellular carcinomas.

MATSUSHIMA MASAYA, NAGANAWA SHINJI, IKEDA MITSURU, ITOH SHIGEKI, OGAWA HIROSHI, KOMADA TOMOHIRO, ISHIGAKI SATOKO, KAWAI HISASHI, SUZUKI KOJIRO, SATAKE HIROKO, IWANO SHINGO

Magn Reason Med Sci 9 巻 ( 2 ) 頁： 49-58 2010年9月

Estimation of Gadolinium-induced T(1)-shortening with Measurement of Simple Signal Intensity Ratio between the Cochlea and Brain Parenchyma on 3D-FLAIR: Correlation with T(1) Measurement by TI Scout Sequence.

NAGANAWA SHINJI, ISHIHARA SHUNICHI, IWANO SHINGO, KAWAI HISASHI, SONE MICHIHIKO, NAKASHIMA TSUTOMU

Magn Reson Med Sci 9 巻 ( 1 ) 頁： 17-22 2010年9月

Three-dimensional angiography of aberrant segmental vein of right upper lobe. 査読有り

Usami N, Iwano S, Mizuno T, Taniguchi T, Yokoi K

Asian cardiovascular & thoracic annals 18 巻 ( 4 ) 頁： 398 2010年8月

Differential TH1/TH2 chemokine expression in interstitial pneumonia. 査読有り

Honda T, Imaizumi K, Yokoi T, Hashimoto N, Hashimoto I, Kawabe T, Matsuo M, Iwano S, Shimokata K, Hasegawa Y.

Am J Med Sci. 339 巻 ( 1 ) 頁： 41-48 2010年1月

Three-dimensional (3D) visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: optimization of a 3D-real inversion-recovery turbo spin-echo (TSE) sequence and application of a 32-channel head coil at 3T. 査読有り

Naganawa S, Ishihara S, Iwano S, Sone M, Nakashima T.

J Magn Reson Imaging 31 巻 ( 1 ) 頁： 210-214 2010年

Comparisons of I-123 diagnostic and I-131 post-treatment scans for detecting residual thyroid tissue and metastases of differentiated thyroid cancer. 査読有り

Iwano S, Kato K, Nihashi T, Ito S, Tachi Y, Naganawa S

Annals of nuclear medicine 23 巻 ( 9 ) 頁： 777-82 2009年11月

Semi-automatic volumetric measurement of lung cancer using multi-detector CT effects of nodule characteristics. 査読有り

Iwano S, Okada T, Koike W, Matsuo K, Toya R, Yamazaki M, Ito S, Ito J, Naganawa S.

Acad Radiol. 16 巻 ( 10 ) 頁： 1179-86 2009年10月

【ボーダレス時代のPACS&WS選び　高機能化と多機能化が画像診断に福音をもたらす】 PACS&WS導入施設報告　PACSと3D WS併用施設報告　仮想気管支鏡(virtual bronchoscopy)の配信におけるPACSとWSの連携

岩野信吾

INNERVISION 24 巻 ( 7 ) 頁： 27-29 2009年6月

*3D-CT volumetry of the lung using multidetector row CT: comparison with pulmonary function tests.

Iwano, Shingo; Okada, Tohru; Satake, Hiroko; Naganawa, Shinji

Acad Radiol ( 16 ) 頁： 250-256 2009年3月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

RATIONALE AND OBJECTIVES: The aim of this study was to evaluate the accuracy of measurements of lung volumes reconstructed using three-dimensional computed tomographic (CT) imaging from thin-section multidetector-row CT images compared to standard pulmonary function testing. MATERIALS AND METHODS: Preoperative three-dimensional CT images and pulmonary function test results of 64 patients with solitary pulmonary nodules who were considered candidates for lung resection were reviewed. On the three-dimensional CT images, total lung capacity (TLC(CTV)), emphysematous lung capacity (ELC(CTV)), and normal lung capacity (NLC(CTV)) were calculated. Total lung capacity (TLC), vital capacity, and forced expiratory volume in 1 second were measured using spirometry. RESULTS: There was a strong positive correlation between estimated TLC(CTV) and measured TLC values (r = 0.87, P < .001). Estimated ELC(CTV) at the threshold value of -900 Hounsfield units was negatively correlated with forced expiratory volume in 1 second (r = -0.56, P < .001). NLC(CTV) values were more strongly correlated with vital capacity values than TLC(CTV) values (r = 0.74, P < .001). CONCLUSIONS: Lung volume calculated using three-dimensional CT volumetry was well correlated with lung volume measured using spirometry. Three-dimensional CT volumetry can be used to evaluate pulmonary function.

Computer-aided diagnosis of lung cancer: definition and detection of ground-glass opacity type of nodules by high-resolution computed tomography. 査読有り

Okada T, Iwano S, Ishigaki T, Kitasaka T, Hirano Y, Mori K, Suenaga Y, Naganawa S.

Jpn J Radiol. 27 巻 ( 2 ) 頁： 91-99 2009年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: The ground-glass opacity (GGO) of lung cancer is identified only subjectively on computed tomography (CT) images as no quantitative characteristic has been defined for GGOs. We sought to define GGOs quantitatively and to differentiate between GGOs and solid-type lung cancers semiautomatically with a computer-aided diagnosis (CAD). METHODS AND MATERIALS: High-resolution CT images of 100 pulmonary nodules (all peripheral lung cancers) were collected from our clinical records. Two radiologists traced the contours of nodules and distinguished GGOs from solid areas. The CT attenuation value of each area was measured. Differentiation between cancer types was assessed by a receiver-operating characteristic (ROC) analysis. RESULTS: The mean CT attenuation of the GGO areas was -618.4 +/- 212.2 HU, whereas that of solid areas was -68.1 +/- 230.3 HU. CAD differentiated between solidand GGO-type lung cancers with a sensitivity of 86.0% and specificity of 96.5% when the threshold value was -370 HU. Four nodules of mixed GGOs were incorrectly classified as the solid type. CAD detected 96.3% of GGO areas when the threshold between GGO and solid areas was 194 HU. CONCLUSION: Objective definition of GGO area by CT attenuation is feasible. This method is useful for semiautomatic differentiation between GGOs and solid types of lung cancer.

Detection of presumed hemorrhage in the ampullar endolymph of the semicircular canal: a case report. 査読有り

Naganawa S, Ishihara S, Iwano S, Sone M, Nakashima T.

Magn Reson Med Sci. 8 巻 ( 4 ) 頁： 187-191 2009年

Automated anatomical labeling of bronchial branches extracted from CT datasets based on machine learning and combination optimization and its application to bronchoscope guidance. 査読有り

Mori K, Ota S, Deguchi D, Kitasaka T, Suenaga Y, Iwano S, Hasegawa Y, Takabatake H, Mori M, Natori H

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 12 巻 ( Pt 2 ) 頁： 707-14 2009年

Diagnostic whole-body scanning before radioiodine therapy for pulmonary metastases of differentiated thyroid cancer: predictive value and recommendations. 査読有り

Tachi Y, Iwano S, Kato K, Tadokoro M, Naganawa S

Clin Nucl Med 33 巻 ( 12 ) 頁： 845-51 2008年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

RATIONALE:: Radioiodine therapy improves the survival of patients with pulmonary metastases of differentiated thyroid cancer (DTC). It is controversial whether the diagnostic whole-body I-131 scan (DWS) before therapy is essential. We determined whether DWS could predict the efficacy of I-131 therapy for pulmonary metastases. METHODS:: We undertook a retrospective review of records of 42 patients (28 women and 14 men, mean age 52.7 years). The patients had received 62 rounds of I-131 therapy for lung metastases of DTC at our institution between June 2002 and June 2006. On the same day that the DWS (dose of 185 MBq) (5 mCi) was completed, the patient received I-131 therapy (dose of 3700-7400 MBq) (100-200 mCi). Post-therapy whole-body scans (PWS) were performed after 3 to 4 days and 7 to 8 days. For all therapies, chest CT images were obtained before I-131 therapy, and 3 and 6 months after therapy for evaluation of therapeutic effectiveness. In addition, serum thyroglobulin (Tg) values were measured before and after the radioiodine therapy for all treatments. RESULTS:: In the group demonstrating I-131 accumulation for pulmonary metastases on DWS, 72% of patients showed a reduction of pulmonary metastases on follow-up CT. On the other hand, in the group that failed to accumulate I-131 on DWS, only 5% of patients showed a reduction of pulmonary metastases. After therapy, serum Tg levels decreased significantly in the group that initially showed accumulation of I-131 in DWS (P = 0.045). In contrast, no remarkable changes between pre- and post-therapy Tg levels were observed in patients who failed to accumulate I-131 in DWS. CONCLUSION:: A whole-body I-131 diagnostic scan before I-131 therapy has a predictive value for the efficacy of therapeutic radioiodine treatment for pulmonary metastases of differentiated thyroid cancer.

Communication between cochlear perilymph and cerebrospinal fluid through the cochlear modiolus visualized after intratympanic administration of Gd-DTPA.

Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Sone, Michihiko; Nakashima, Tsutomu

Radiat Med 26 巻頁： 597-602 2008年9月

*Computer-aided differentiation of malignant from benign solitary pulmonary nodules imaged by high-resolution CT. 査読有り

Iwano S, Nakamura T, Kamioka Y, Ikeda M, Ishigaki T.

Comput Med Imaging Graph. 32 巻 ( 5 ) 頁： 416-22. 2008年7月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

We investigated the possibility of using computer analysis of high-resolution CT images to radiologically classify the shape of pulmonary nodules. From a total of 107 HRCT images of solid, solitary pulmonary nodules with prior differentiation as benign (n=55) or malignant (n=52), we extracted the desired pulmonary nodules and calculated two quantitative parameters for characterizing nodules: circularity and second central moment. Using discriminant analysis for two thresholds in differentiating malignant from benign states resulted in a sensitivity of 76.9%, a specificity of 80%, a positive predictive value of 78.4%, and a negative predictive value of 78.6%.

Contrast-enhanced MR imaging of the brain using T1-weighted FLAIR with BLADE compared with a conventional spin-echo sequence.

Naganawa Shinji, Satake Hiroko, Iwano Shingo, Kawai Hisashi, Kubota Seiji, Komada Tomohiro, Kawamura Minako, Sakurai Yasuo, Fukatsu Hiroshi

Eur Radiol 18 巻 ( 2 ) 頁： 337-342 2008年2月

Interactions of perceptual and conceptual processing:Expertise in medical image diagnosis.

Morita, J., Miwa, K., Kitasaka, T., Mori, K., Suenaga, Y., Iwano, S., Ikeda, M., and Ishigaki, T

Int. J. Human-computer Studies 66 巻 ( 208 ) 頁： 370-390 2008年

Imaging endolymphatic hydrops at 3 tesla using 3D-FLAIR with intratympanic Gd-DTPA administration.

Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Fukatsu, Hiroshi; Sone, Michihiko; Nakashima, Tsutomu

Magn Reson Med Sci 7 巻頁： 85-91 2008年

Solitary fibrous tumor of the pleura: evaluation of the origin with 3D CT angiography. 査読有り

Usami N, Iwano S, Yokoi K.

J Thorac Oncol. 2 巻 ( 12 ) 頁： 1124-5. 2007年12月

類似CT画像検索CADの試み

岩野信吾, 岡田徹, 神岡祐子, 石垣武男, 長縄慎二

映像情報Medical 39 巻 ( 13 ) 頁： 1215-19 2007年12月

Usefulness of dynamic computed tomography for the diagnosis of mediastinal hemangioma. 査読有り

Okasaka T, Iwano S, Usami N, Uchiyama M, Sato N, Yokoi K.

60 巻 ( 11 ) 頁： 1031-4 2007年10月

Comparison of 18F-FDG PET and Bone Scintigraphy in Detection of Bone Metastases of Thyroid Cancer.

Ito S, Kato K, Ikeda M, Iwano S, Makino N, Tadokoro M, Abe S, Nakano S, Nishino M, Ishigaki T, Naganawa S

J Nucl Med 48 巻頁： 889-895 2007年

記述言語：英語掲載種別：研究論文（学術雑誌）

We compared the efficacies of (18)F-FDG PET and (99m)Tc-bone scintigraphy for the detection of bone metastases in patients with differentiated thyroid carcinoma (DTC). METHODS: We examined 47 patients (32 women, 15 men; mean age +/- SD, 57.0 +/- 10.7 y) with DTC who had undergone total thyroidectomy and were hospitalized to be given (131)I therapy. All patients underwent both whole-body (18)F-FDG PET and (99m)Tc-bone scintigraphy. The skeletal system was classified into 11 anatomic segments and assessed for the presence of bone metastases. Bone metastases were verified either when positive findings were obtained on >2 imaging modalities-(201)Tl scintigraphy, (131)I scintigraphy, and CT-or when MRI findings were positive if vertebral MRI was performed. RESULTS: Bone metastases were confirmed in 59 of 517 (11%) segments in 18 (38%) of the 47 study patients. The sensitivities (visualization rate) for bone metastases on a segment basis using (18)F-FDG PET and (99m)Tc-bone scintigraphy were 50 of 59 (84.7%) and 46 of 59 (78.0%), respectively; the difference between these values was not statistically significant. There were only 2 (0.4%) false-positive cases in a total of 451 bone segments without bone metastases when examined by (18)F-FDG PET, whereas 39 (8.6%) were false-positive when examined by (99m)Tc-bone scintigraphy. Therefore, the specificities of (18)F-FDG PET and (99m)Tc-bone scintigraphy were 449 of 451 (99.6%) and 412 of 451 (91.4%), respectively; the difference between these values was statistically significant (P < 0.001). The overall accuracies of (18)F-FDG PET and (99m)Tc-bone scintigraphy were 499 of 510 (97.8%) and 458 of 510 (89.8%), respectively; the difference between these was also statistically significant (P patients has recently improved. In particular, patients with good PS showed better local control than those with poor PS. However, we could not identify any significant prognostic factors in PCNSL patients.

【膵疾患の画像診断最近のトレンド】マルチスライスCT診断

伊藤茂樹, 石垣聡子, 鈴木耕次郎, 岩野信吾, 長縄慎二

臨床画像 22 巻 ( 12 ) 頁： 1334-1342 2006年12月

Application of subsecond rotation scan to helical CT for lung cancer screening. 査読有り

Mori Y, Itoh S, Ikeda M, Sawaki A, Suzuki K, Iwano S, Satake H, Arahata S, Ota T, Ishigaki T

Nagoya journal of medical science 68 巻 ( 3-4 ) 頁： 139-45 2006年6月

Cerebral glucose metabolism change in patients with complex regional pain syndrome: a PET study.

Shiraishi S, Kobayashi H, Nihashi T, Kato K, Iwano S, Nishino M, Ishigaki T, Ikeda M, Kato T, Ito K, Kimura T

Radiat Med 24 巻頁： 335-344 2006年

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: The aim of this study was to examine abnormalities of the central nervous system in patients with chronic pain who were diagnosed with complex regional pain syndrome (CRPS). MATERIALS AND METHODS: Brain activity was assessed using (18)F-fluorodeoxyglucose positron emission tomography. The data collected from 18 patients were compared with data obtained from 13 normal age-matched controls. RESULTS: Our results showed that glucose metabolism was bilaterally increased in the secondary somatosensory cortex, mid-anterior cingulated cortex (ACC) or posterior cingulated cortex (PCC) (or both), parietal cortex, posterior parietal cortex (PPC), and cerebellum as well as in the right posterior insula and right thalamus in our patients. In contrast, glucose metabolism was reduced contralaterally in the dorsal prefrontal cortex and primary motor cortex. Glucose metabolism was bilaterally elevated in the mid-ACC/PCC and the PPC, which correlated with pain duration. CONCLUSION: These data suggested that glucose metabolism in the brains of patients with CRPS changes dramatically at each location. In particular, glucose metabolism was increased in the areas concerned with somatosensory perception, possibly due to continuous painful stimulation.

Application of subsecond rotation scan to helical CT for lung cancer screening.

Mori, Yoshine; Itoh, Shigeki; Ikeda, Mitsuru; Sawaki, Akiko; Suzuki, Koujiro; Iwano, Shingo; Satake, Hiroko; Arahata, Shoji; Ota, Toyohiro; Ishigaki, Takeo

Nagoya J Med Sci 68 巻頁： 139-145 2006年

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: To clarify whether the benefit of a reduced effective scan width obtained using a smaller pitch outweighs the disadvantage of increased noise in the application of a subsecond helical CT to mass screenings for lung cancer. MATERIALS AND METHODS: Twenty-two helical CT scans of the lung were obtained in 11 healthy subjects using the following parameters: 1) scan 1 was performed at 120 kVp, 50 mA, 10-mm collimation, 1-second/rotation, helical pitch of 2.0; and 2) scan 2 was performed at 120 kVp, 50 mA, 10-mm collimation, 0.75-second/rotation, helical pitch of 1.5. Computer-generated nodules measuring 10 mm and 6 mm in diameter showing ground-glass opacity were superimposed on these images. The detectability of each nodule was evaluated by six blinded readers using ROC analysis. RESULTS: Detectability of the 6-mm nodules was significantly higher in scan 2 than in scan 1. Detectability of the 10-mm nodules was not significantly different between scans 1 and 2. CONCLUSION: The use of a smaller pitch by employing a subsecond rotation scan in a helical CT for lung cancer screenings improves the detection of small lesions without increasing either the scanning time or radiation dose.

Diagnostic value of curved multiplanar reformatted images in multislice CT for the detection of resectable pancreatic ductal adenocarcinoma.

Fukushima H, Itoh S, Takada A, Mori Y, Suzuki K, Sawaki A, Iwano S, Satake H, Ota T, Ikeda M, Ishigaki T

Eur Radiol 16 巻頁： 1709-1718 2006年

記述言語：英語掲載種別：研究論文（学術雑誌）

The purpose of this study was to assess the usefulness of curved multiplanar reformatted (MPR) images obtained by multislice CT for the depiction of the main pancreatic duct (MPD) and detection of resectable pancreatic ductal adenocarcinoma. This study included 28 patients with pancreatic carcinoma (size range 12-40 mm) and 22 without. Curved MPR images with 0.5-mm continuous slices were generated along the long axis of the pancreas from pancreatic-phase images with a 0.5- or 1-mm slice thickness. Seven blinded readers independently interpreted three sets of images (axial images, curved MPR images, and both axial and curved MPR images) in scrolling mode. The depiction of the MPD and the diagnostic performance for the detection of carcinoma were statistically compared among these images. MPR images were significantly superior to axial images in depicting the MPD, and the use of both axial and MPR images resulted in further significant improvements. For the detection of carcinoma, MPR images were equivalent to axial images, and the diagnostic performance was significantly improved by the use of both axial and MPR images. High-resolution curved MPR images can improve the depiction of the MPD and the diagnostic performance for the detection of carcinoma compared with axial images alone.

皮膚原発悪性黒色腫と転移巣における123I-IMPシンチグラフィ　18F-FDG PETとの比較

加藤克彦, 伊藤信嗣, 岩野信吾, 石垣武男, 池田充, 田所匡典, 小林英敏

核医学 43 巻頁： 360 2006年

甲状腺癌の骨転移診断における18F－FDG－ペTと骨シンチグラフィの比較

伊藤信嗣、加藤克彦、岩野信吾、石垣武男、田所匡典、牧野直樹、池田充

核医学 43 巻頁： 95 2006年

*Computer-aided diagnosis: A shape classification of pulmonary nodules imaged by high-resolution CT. 査読有り

Iwano S, Nakamura T, Kamioka Y, Ishigaki T

Comput Med Imaging Graph. 29 巻 ( 7 ) 頁： 565-570 2005年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

We investigated the possibility of using computer analysis of high-resolution CT images to radiologically classify the shape of pulmonary nodules. Using a combination of circularity and second moment as quantitative measures we were able to classify pulmonary nodules in each shape group as effectively as could a radiologist. We found that pulmonary nodules with circularity < or =0.75 and second moment < or =0.18 were very likely to reveal lung cancer.

Branch duct-type intraductal papillary mucinous tumor: diagnostic value of multiplanar reformatted images in multislice CT.

Takada A, Itoh S, Suzuki K, Iwano S, Satake H, Ota T, Ikeda M, Ishigaki T

Eur Radiol 15 巻頁： 1888-1897 2005年

記述言語：英語掲載種別：研究論文（学術雑誌）

The object of this study was to evaluate the usefulness of high-resolution multiplanar reformatted (MPR) images obtained by multislice CT in demonstrating connection between pancreatic cystic lesions and the main pancreatic duct. The study included 27 lesions with connection to the main pancreatic duct and 12 lesions without. All but one of the former lesions were branch duct-type intraductal papillary mucinous tumors (IPMTs). Oblique and curved MPR images with 0.5 mm continuous slices were generated from pancreatic-phase axial images reconstructed with 0.5 mm or 1 mm thickness at 0.5 mm intervals over a 260 mm field of view. The diagnostic capabilities for demonstrating connection with the main pancreatic duct were compared among axial images, MPR images, and both axial and MPR images in combination using the Brier score. The diagnosis in MPR images for demonstrating connection was more certain than that in axial images (P<0.05). Compared with MPR images alone, the use of both axial and MPR images resulted in further improvements in diagnostic performance, although the difference was not statistically significant. The use of high-resolution MPR images significantly improves diagnostic performance for demonstrating connection between pancreatic cystic lesions and the main pancreatic duct, which is useful for the diagnosis of branch duct-type IPMT.

Three-phase CT examination of the pancreatobiliary region using multislice CT with 1-mm collimation.

Itoh S, Suzuki K, Iwano S, Satake H, Ota T, Ikeda M, Ishigaki T

Radiat Med 23 巻頁： 283-291 2005年

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: To evaluate the degree of contrast enhancement and accuracy of imaging of the circulatory phase in the first-pass, second-pass, and third-pass acquisitions in the pancreato-biliary region with 1-mm collimation obtained by multislice computed tomography (CT). MATERIALS AND METHODS: In 53 patients, two sequential acquisitions from the porta hepatis to the pancreas were performed during a single breath-hold, followed by a third-pass acquisition including the liver beginning 15 sec after the second-pass acquisition. Contrast enhancement in each acquisition was measured in the aorta, portal vein and its branches, and pancreas. Four experienced radiologists graded using four-point scoring whether or not each acquisition was appropriate for imaging of the arterial phase, pancreatic phase, and portal venous phase. RESULTS: Aortic enhancement was highest at the beginning of the second-pass acquisition. The portal and splenic veins and pancreas showed maximum enhancement in the second-pass acquisition, while the superior mesenteric vein showed maximum enhancement in the third-pass acquisition. In the visual assessment, significantly higher grades were achieved in the first-pass, second-pass, and third-pass acquisitions with regard to imaging of the arterial phase, pancreatic phase, and portal venous phase, respectively. CONCLUSION: Multislice CT permits the acquisition of three distinct circulatory phases (arterial, pancreatic, and portal venous phases) in the pancreatobiliary region with 1-mm collimation.

Late-arterial and portal-venous phase imaging of the liver with a multislice CT scanner in patients without circulatory disturbances: automatic bolus tracking or empirical scan delay?

Itoh S, Ikeda M, Achiwa M, Satake H, Iwano S, Ishigaki T

Eur Radiol 14 巻頁： 1665-1673 2004年

記述言語：英語掲載種別：研究論文（学術雑誌）

The value of automatic bolus tracking in late-arterial and portal-venous phase imaging of the liver with a multislice CT scanner as compared with fixed time-delay examination in patients without circulatory disturbances is evaluated. For the evaluation of known or suspected liver disease, 98 multiphase contrast-enhanced CT examinations including double late-arterial phase imaging were randomized into either scanning with a scan delay of 30 s from the beginning of contrast material injection or scanning with automatic bolus tracking. Contrast material was injected at 0.07 ml/kg body weight/s over 30 s. Contrast enhancement in each acquisition was measured in the aorta, portal vein, liver, pancreas and hepatocellular carcinomas. The density difference between hepatocellular carcinomas and the hepatic parenchyma was calculated. The mean time to the first-pass acquisition as determined by automatic bolus tracking was 29.6 s. No statistically significant difference was observed between the two groups either in any enhancement in any acquisition or in the lesion-to-liver density difference. The use of automatic bolus tracking in late-arterial and portal-venous phase hepatic CT does not significantly improve the degree of contrast enhancement in the aorta, portal vein, liver and pancreas or lesion-to-liver conspicuity in patients without circulatory disturbances.

Solitary pulmonary nodules: Optimal slice thickness of high-resolution CT in differentiating malignant from benign. 査読有り

Iwano S, Makino N, Ikeda M, Itoh S, Tadokoro M, Satake H, Ishigaki T

Clinical Imaging 28 巻頁： 322-328 2004年

Lung: feasibility of a method for changing tube current during low-dose helical CT.

Itoh S, Ikeda M, Mori Y, Suzuki K, Sawaki A, Iwano S, Satake H, Arahata S, Isomura T, Ozaki M, Ishigaki T

Radiology 224 巻頁： 905-912 2002年

記述言語：英語掲載種別：研究論文（学術雑誌）

A method for changing the tube current during helical scanning was applied to low-dose computed tomography (CT) in the lung. The changing method resulted in significant equalization of image noise in various lung sections compared with that at scanning with constant tube current. Detectability of nodules was equivalent between 60 mA and the changing method, whereas degradation occurred at 20 mA. This method seems feasible for the low-dose CT of lung cancer screening.

Detection of Subtle Pulmonary Disease on CR Chest Images: Monochromatic CRT Monitor vs. Color CRT Monitor 査読有り

Iwano S, Ishigaki T, Shimamoto K, Inamura K, Maeda T, Ikeda M, Ishiguchi T, Kozuka T

European Radiology 11 巻 ( 1 ) 頁： 59-94 2001年1月

Further reduction of radiation dose in helical CT for lung cancer screening using small tube current and a newly designed filter.

Itoh S, Koyama S, Ikeda M, Ozaki M, Sawaki A, Iwano S, Ishigaki T

J Thorac Imaging 16 巻頁： 81-88 2001年

記述言語：英語掲載種別：研究論文（学術雑誌）

A new aluminum filter, 5.8 mm thick at the center, was designed. The effective energy, exposure dose, absorbed dose, and noise were measured by using low-dose technique, very low-dose technique with a conventional filter, and very low-dose technique with a new filter on a chest phantom. Accuracy of very low-dose computed tomography (CT) with a new filter was compared against standard helical CT in 40 patients and against chest radiography in 35 patients. Effective energies were 42.6 keV and 51.6 keV at a conventional filter and the new filter, respectively. Compared against 20mA with a conventional filter, exposure dose was reduced by 17%, and absorbed dose was equivalent, at 30 mA with the new filter. Noise was improved by 9%. Compared with standard helical CT, the sensitivity, specificity, and accuracy of very-low-dose helical CT were 100%, 88%, and 95%, respectively. Very-low-dose helical CT was found to be significantly superior to chest radiography in the detection of lung cancers. Using a smaller tube current and an appropriate filter allows a further reduction in radiation dose in helical CT for lung cancer screening.

Videotaped Helical CT Images for Lung Cancer Screening 査読有り

Iwano S, Makino N, Ikeda M, Itoh S, Ishihara S, Tadokoro M, Ishigaki T.

J Comput Assist Tomogr 24 巻 ( 2 ) 頁： 242-246 2000年3月

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