Updated on 2021/03/24

写真a

 
HAYASHI, Toshio
 
Organization
Nagoya University Graduate School of Medicine Professor
Title
Professor
Contact information
メールアドレス

Degree 1

  1. Doctor of Medicine ( Nagoya University ) 

Research Interests 2

  1. 介護保険

  2. 老年内科学、在宅医療、高齢者医療、血管内科学、糖尿病学、老化、性差

Research Areas 6

  1. Others / Others  / General Internal Medicine (includes Psychosomatic Medicine)

  2. Others / Others  / 糖尿病学

  3. Others / Others  / 在宅医学

  4. Others / Others  / (Geriatric) Metabolism and Endocrinology

  5. Others / Others  / (Geriatric)Cardiology

  6. Others / Others  / Gender

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Current Research Project and SDGs 11

  1. 糖尿病患者における心血管イベント発症に関する後ろ向きコホートに関する研究

  2. 血管老化と糖尿病性血管合併症の関連 -ヒトバイオマーカーの可能性-

  3. 高齢者の健康維持を目的とした性差医療の実態と必要性の検討

  4. 原発性高脂血症に関する調査研究

  5. Aging and vascular endocrinology

  6. Pathophysiology of progression and regrassion of atherosclerosis

  7. The role of nitric oxide and sex steroid on atherosclerosis

  8. 高齢在宅医療患者の終末期医療

  9. 高齢者薬物療法ー相互作用、反応個人差を中心にー

  10. 高齢女性の動脈硬化性疾患予防と健康長寿を目指すアジア老年医学研究

  11. 細胞老化制御による進行動脈硬化症治療―本邦高齢者へのオーダーメイド治療を目指すー

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Research History 7

  1. 名古屋大学大学院医学系研究科   教授

    2016.6

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    Country:Japan

  2. 名古屋大学医学部附属病院老年科講師

    2002

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    Country:Japan

  3. Nagoya University

    2002

  4. 名古屋大学医学部附属病院老年科助手

    1998 - 2002

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    Country:Japan

  5. 名古屋大学医学部附属病院老年科医員

    1992 - 1998

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    Country:Japan

  6. Post doctoral fellow (UCLA Department of Pharmacology)

    1991 - 1992

  7. 名古屋第二赤十字病院研修医

    1984 - 1986

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medicine

    1986 - 1990

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    Country: Japan

  2. Shinshu University   Faculty of Medicine

    1978.4 - 1984.3

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    Country: Japan

Professional Memberships 16

  1. 日本老年医学会   評議員

    1996.4

  2. 日本老年学会   将来計画委員

    1997.4

  3. 日本内科学会(総合内科専門医部会)   指導医,東海支部幹事

  4. 日本糖尿病学会   研修指導医

  5. 日本動脈硬化学会   評議員,財務委員

    1997.4

  6. 日本在宅医学会

  7. 日本内分泌学会   代議員

  8. 日本ケアマネジメント学会   (介護支援専門員)

  9. 日本循環器学会

  10. 日本心脈管作動物質学会   評議員

  11. 日本基礎老化学会   評議員

    2006.4 - 2010.3

  12. 日本心血管内分泌学会   評議員

  13. 日本NO学会   評議員

  14. European Association for the Study of Diabetes

  15. American Geriatric Society

  16. Gerontological Society of America

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Awards 3

  1. 日本老年医学会ノバルテイスファーマ賞

    2007  

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    Country:Japan

  2. 心臓脈管作動物質学会賞

    1998  

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    Country:Japan

  3. サンド老年医学会賞(現日本老年医学会ノバルテイスファーマ賞)

    1994  

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    Country:Japan

 

Papers 116

  1. [Prevention of the progression of atherosclerosis and aging through nitric oxide (NO)].

    Hayashi T

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica   Vol. 155 ( 2 ) page: 62-68   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1254/fpj.19148

    PubMed

  2. An Inhibitor of Activated Blood Coagulation Factor X Shows Anti-Endothelial Senescence and Anti-Atherosclerotic Effects

    Maeda Morihiko, Tsuboi Tomoe, Hayashi Toshio

    JOURNAL OF VASCULAR RESEARCH   Vol. 56 ( 4 ) page: 181-190   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000499975

    Web of Science

    PubMed

  3. Relationship between blood coagulability and sense of burden among caregivers of patients with dementia

    Hirano Akemi, Suzuki Yusuke, Umegaki Hiroyuki, Hayashi Toshio, Ina Koichiro, Onishi Joji, Hasegawa Jun, Kuzuya Masafumi

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 19 ( 8 ) page: 804-808   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ggi.13721

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    PubMed

  4. Vascular Senescense and Endothelial Function - Can We Apply It to Atrial Fibrillation? -

    Hayashi Toshio

    CIRCULATION JOURNAL   Vol. 83 ( 7 ) page: 1439-1440   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-19-0446

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    PubMed

  5. Association between sarcopenia and depressive mood in urban-dwelling older adults: A cross-sectional study

    Hayashi Takahiro, Umegaki Hiroyuki, Makino Taeko, Cheng Xian W., Shimada Hiroyuki, Kuzuya Masafumi

    GERIATRICS & GERONTOLOGY INTERNATIONAL   Vol. 19 ( 6 ) page: 508-512   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ggi.13650

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  6. Low HDL-C is an Age Dependent Predictors of Ischemic Heart Disease and Cerebrovascular Attack as well as Advanced Triopathy in Diabetic Individuals: Lessons from 9.2 years Study of 4014 Diabetic Patients including 1016 Late Elderly older than 75 y.o.

    Hayashi T.

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   Vol. 67   page: S166-S166   2019.4

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    Web of Science

  7. The Role of NO in the Progression and Regression of Atherosclerosis via Endothelial Senescence

    Hayashi T., Maeda M.

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   Vol. 67   page: S63-S63   2019.4

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    Web of Science

  8. Napping Improves HRV in Older Patients With Cardiovascular Risk Factors.

    Nakayama N, Hayashi T, Miyachi M, Negi K, Watanabe K, Hirai M

    Western journal of nursing research     page: 193945918824603   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0193945918824603

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  9. Association between insulin resistance and objective measurement of physical activity in community-dwelling older adults without diabetes mellitus

    Umegaki Hiroyuki, Makino Taeko, Uemura Kazuki, Shimada Hiroyuki, Hayashi Takahiro, Cheng Xian Wu, Kuzuya Masafumi

    DIABETES RESEARCH AND CLINICAL PRACTICE   Vol. 143   page: 267-274   2018.9

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    DOI: 10.1016/j.diabres.2018.07.022

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  10. Best Treatment Strategies With Statins to Maximize the Cardiometabolic Benefits

    Cho Kyoung Im, Sakuma Ichiro, Sohn Il Suk, Hayashi Toshio, Shimada Kazunori, Koh Kwang Kon

    CIRCULATION JOURNAL   Vol. 82 ( 4 ) page: 937-943   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-17-1445

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  11. Cognitive Dysfunction in Urban-Community Dwelling Prefrail Older Subjects

    Umegaki H., Makino T., Shimada H., Hayashi T., Cheng X. Wu, Kuzuya M.

    JOURNAL OF NUTRITION HEALTH & AGING   Vol. 22 ( 4 ) page: 549-554   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12603-018-1017-5

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  12. Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence

    Tsuboi Tomoe, Maeda Morihiko, Hayashi Toshio

    PLOS ONE   Vol. 13 ( 2 ) page: e0192252   2018.2

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    DOI: 10.1371/journal.pone.0192252

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  13. The Associations among Insulin Resistance, Hyperglycemia, Physical Performance, Diabetes Mellitus, and Cognitive Function in Relatively Healthy Older Adults with Subtle Cognitive Dysfunction

    Umegaki Hiroyuki, Makino Taeko, Uemura Kazuki, Shimada Hiroyuki, Hayashi Takahiro, Cheng Xian Wu, Kuzuya Masafumi

    FRONTIERS IN AGING NEUROSCIENCE   Vol. 9   2017.3

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    DOI: 10.3389/fnagi.2017.00072

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  14. The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males

    Suzuki Takashi, Morita Masahiko, Hayashi Toshio, Kamimura Ayako

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 81 ( 2 ) page: 372-375   2017.2

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    DOI: 10.1080/09168451.2016.1230007

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  15. Combining Potent Statin Therapy with Other Drugs to Optimize Simultaneous Cardiovascular and Metabolic Benefits while Minimizing Adverse Events Reviewed

    Kwang Kon Koh, Ichiro Sakuma, Kazunori Shimada, Toshio Hayashi

    Korean Circulation Journal   Vol. 47   page: 15-20   2017.2

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  16. The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males. Reviewed

    Suzuki T, Morita M, Hayashi T, Kamimura A

    Biosci Biotechnol Biochem   Vol. 26   page: 1-4   2016.12

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  17. Angiotensin converting enzyme inhibitors remain the first treatment of choice Reviewed

    Oh PC, Sakuma I, Hayashi T, Koh KK

    Korean J Intern Med   Vol. 31   page: 237-241   2016.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3904/kjim.2016.026

  18. Vascular and metabolic effects of ezetimibe combined with simvastatin in patients with hypercholesterolemia. Reviewed

    Koh KK, Oh PC, Sakuma I, Kim EY, Lee Y, Hayashi T, Han SH, Park YM, Shin EK.

    Int J Cardiol.   Vol. 199   page: 126-131   2015.11

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    DOI: 10.1016/j.ijcard.2015.07.016.

  19. Effects of leisure activities at home on perceived care burden and the endocrine system of caregivers of dementia patients: a randomized controlled study. Reviewed

    Hirano A, Umegaki H, Suzuki Y, Hayashi T, Kuzuya M.

    Int Psychogeriatr   Vol. 20   page: 1-8   2015.8

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  20. Pleiotropic benefits of metformin: macrophage targeting its anti-inflammatory mechanisms Reviewed

    Hattori Y, Hattori K, Hayashi T.

    Diabetes   Vol. 64 ( 6 ) page: 1907-1909   2015.6

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    DOI: 10.2337/db15-0090

  21. Renin-angiotensin system inhibitor and statins combination therapeutics-what have we learnt? Reviewed

    Koh KK, Sakuma I, Hayashi T, Kim SH, Chung WJ.

    Expert Opin Pharmacother.   Vol. 16 ( 7 ) page: 949-953   2015.5

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    DOI: 10.1517/14656566.2015.1019464.

  22. Intermittent high glucose implements stress-induced senescence in human vascular endothelial cells: role of superoxide production by NADPH oxidase Reviewed

    Maeda M, Hayashi T, Mizuno N, Hattori Y, Kuzuya M.

    PLoS One   Vol. 10 ( 4 ) page: e0123169   2015.4

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    DOI: 10.1371/journal.pone.0123169.

  23. Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75 years among 4014 type 2 diabetic individuals Reviewed

    Hayashi T, Kubota K, Kawashima S, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Araki A, Noda M, Noto H, Sakuma I, Yoshizumi M, Ina K, Nomura H; Japan CDM group

    Int J Cardiol.   Vol. 177 ( 3 ) page: 860-866   2014.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcard.2014.10.093

  24. Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability Reviewed

    M Morita, Hayashi T, Ochiai M, Maeda, M, Yamaguchi T,Ina K, Kuzuya M.

    Biochem Biophys Res. Commun.   Vol. 454 ( 1 ) page: 53-57   2014.11

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    DOI: 10.1016/j.bbrc.2014.10.029

  25. Importance of high-density lipoprotein cholesterol levels in elderly diabetic individuals with type IIb dyslipidemia: A 2-year survey of cardiovascular events. Reviewed

    Ina K, Hayashi T. et al.

    Geriatr Gerontol Int.     2014

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    DOI: doi: 10.1111/ggi.12168

  26. eNOS-Dependent Antisenscence Effect of a Calcium Channel Blocker in Human Endothelial Cells Reviewed

    Hayashi T, Yamaguchi T, Sakakibara Y, Taguchi K, Maeda M, Kuzuya M, Hattori Y.

    PLoS One   Vol. 9 ( 2 ) page: e88391   2014.2

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    DOI: 10.1371/journal.pone.0088391

  27. Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes. Reviewed

    Hayashi T, Kotani H, Yamaguchi T, Taguchi K, Iida M, Ina K, Maeda M, Kuzuya M, Hattori Y, Ignarro LJ.

    Proc Natl Acad Sci U S A.   Vol. 111 ( 3 ) page: 1168-1173   2014.1

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    DOI: 10.1073/pnas.1322153111

  28. Metabolic predictors of ischemic heart disease and cerebrovascular attack in elderly diabetic individuals: difference in risk by age. Reviewed

    Hayashi T, Araki A, Kawashima S, Sone H, Watanabe H, Ohrui T, Yokote K, Takemoto M, Kubota K, Noda M, Noto H, Ina K, Nomura H; Japan CDM group

    Cardiovasc Diabetol   Vol. 12   page: 10-18   2013.1

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    DOI: 10.1186/1475-2840-12-10

  29. Cognitive dysfunction: an emerging concept of a new diabetic complication in the elderly. Reviewed

    Umegaki H, Hayashi T, Nomura H, Yanagawa M, Nonogaki Z, Nakshima H, Kuzuya M.

    Geriatr Gerontol Int.   Vol. 13 ( 1 ) page: 28-34   2013.1

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    DOI: 10.1111/j.1447-0594.2012.00922.x.

  30. Life style related diseases:dyslipidemia and gender differences Invited Reviewed

      Vol. 101   page: 2342-2349   2012

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  31. Management of type IIb dys- lipidemia Reviewed

    Arai H, Hayashi T. et al.

    J Atheroscler Thromb   Vol. 19   page: 105-114   2012

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  32. Management of type I & V hyperlipidemia Reviewed

    Gotoda T, Hayashi T. et al. The Research Committee for Primary Hyperlipidemia,on Measures against Intractable Diseases by Japan Ministry of Health, Labor & Welfare

    J Atheroscler Thromb   Vol. 19   page: 1-12   2012

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  33. Background to discuss guidelines for control of plasma HDL-cholesterol in Japan Reviewed

    Yokoyama S, Yamashita S, Ishibashi S, Sone H, Oikawa S, Shirai K, Ohta T, Bujo H, Kobayashi J, Arai H, Harada-Shiba M, Eto M, Hayashi T, Gotoda T, Suzuki H, Yamada N.

    J Atheroscler Thromb   Vol. 19 ( 3 ) page: 207-212   2012

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  34. Place of death for the elderly in need of end-of-life home care: A study in Japan Reviewed

    Hayashi T, Nomura H, Ina K, Kato T, Hirose T, Nonogaki Z, Suzuki Y.

    Arch Gerontol Geriatr   Vol. in press   2011.10

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    DOI: doi.10.1016/j.archger.2010.12.005

  35. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men Reviewed

    Ochiai M, Hayashi T, Morita M, Ina K, Maeda M, Watanabe F, Morishita K

    Int J Cardiology   Vol. in press   2011.8

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    DOI: 10.1016/j.ijcard.2010.10.004

  36. Age, gender, insulin and blood glucose control status alter the risk of ischemic heart disease and stroke among elderly diabetic patients Reviewed

    Hayashi T, Kawashima S, Nomura H, Itoh H, Watanabe H, Ohrui T, Yokote K, Sone H, Hattori Y, Yoshizumi M, Ina K, Kubota K; Japan Cholesterol and Diabetes Mellitus Investigation Group.

    Cardiovascular Diabetology   Vol. 10   page: 86-92   2011.8

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  37. Dose-Dependent Modulatory Effects of Insulin on Glucose-induced Endothelial Senescence in vitro and in vivo: A Relationship between Telomeres and Nitric Oxide Reviewed

    Matsui-Hirai H, Hayashi T, Yamamoto S, Ina K, Maeda M, Kotani H, Iguchi A, Ignarro LJ, Hattori Y

    J Pharmacol Exp Ther.     2011.6

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    DOI: 10.1124/jpet.110.177584

  38. Depression, quality of life (QoL) and will to live of community-dwelling postmenopausal women in three Asian countries: Korea, China and Japan Reviewed

    Ina K, Hayashi T, Nomura H, Ishitsuka A, Hirai H, Iguchi A

    Arch Gerontol Geriatr   Vol. in press   2011.6

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    DOI: 10.1016/j.archger.2010.05.010

  39. . Combined effect of testosterone and apocynin on nitric oxide and superoxide production in PMA-differentiated THP-1 cells Reviewed

    Hayashi T, Iguchi A.

    Biochim Biophys Acta.   Vol. 1693   page: 185-191   2004

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  40. The effects of selective estrogen receptor modulator treatment following hormone replacement therapy on elderly postmenopausal women with osteoporosis Reviewed

    Hayashi T, Ina K, Maeda M, Nomura H.

    Nitric Oxide   Vol. 24 ( 4 ) page: 199-203   2011.5

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  41. CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy Reviewed

    de Nigrisa F, Crudelea V, Giovaneb A, Hayashii T, Mohammed Al-Omranj M, Louis J. Ignarroj L.J., Napolia C et al.

    Proc Natl Acad Sci USA   Vol. 107 ( 32 ) page: 14484-14489   2010.8

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  42. Clinical factors such as B-type natriuretic peptide link to factor VII, endothelial NO synthase and estrogen receptor alpha polymorphism in elderly women. Reviewed

    Funami J, Hayashi T, Nomura H, Ding QF, Ishitsuka-Watanabe A, Matsui-Hirai H, Ina K, Zhang J, Yu ZY, Iguchi A

    Life Sci   Vol. 85 ( 7-8 ) page: 316-321   2009

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  43. A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits Reviewed

    Atherosclerosis   Vol. 176   page: 255-63   2004

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  44. Enodothelial Progenitor Cells as Therapeutic Agents in the Microcirculation Reviewed

    Claudio Napoli, Francesco Cacciatore, Toshio Hayashi, Amelia Casamassimi, Costanza Casini, Mohammed Al-Omran, Louis J. Ignarro

    Atherosclerosis   Vol. 215 ( 1 ) page: 9-22   2011.3

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  45. Possibility of the regression of atherosclerosis through the prevention of endothelial senescence by the regulation of nitric oxide and free radical scavengers. Invited Reviewed

    Hayashi T, Iguchi A.

    Geriatr Gerontol Int.   Vol. 10 ( 2 ) page: 115-130   2010.5

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  46. The effect of high glucose on NO and O2- through endothelial GTPCH1 and NADPH oxidase Reviewed

    Life Sci   Vol. 75   page: 3185-94   2004

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  47. The role of insulin growth factor on atherosclerosis and endothelial function: The effect on hyperlipidemia and aging Reviewed

    Hirai H, Kanaya R, Maeda M, Ina K, Hayashi T.

    Life Sciences   Vol. 88 ( 1-2 ) page: 425-431   2011.2

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  48. Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells. Invited Reviewed

    Zhang X-H, Yokoo H, Nishioka H, Fujii H, Matsuda N,Hayashi T, Hattori Y

    British Journal of Pharmacology   Vol. 159   page: 928-938   2010.2

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  49. Strategy for treating elderly Japanese with hypercholesterolemia Reviewed

    Geriatrics Gerontology International   Vol. 4   page: 151-157   2004

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  50. A hydroxymethylglutaryl coenzyme a reductase inhibitor improves endothelial function within 7 days in patients with chronic hemodialysis. Reviewed

    Kishimoto N, Hayashi T, Sakuma I, Kano-Hayashi H, Tsunekawa T, Osawa M, Ina K, Iguchi A.

    Int J Cardiol   Vol. 145 ( 1 ) page: 21-26   2010.11

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  51. *Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages. Reviewed

    Hayashi T, Kawashima S, Itoh H, Yamada N, Sone H, Watanabe H, Hattori Y, Ohrui T, Yokote K, Nomura H, Umegaki H, Iguchi A; Japan CDM Group.

    Diabetes Care   Vol. 32 ( 7 ) page: 1221-23   2009

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  52. 2,4,6-Trinitrotoluene inhibits endothelial nitric oxide synthase activity and elevates blood pressure in rats Reviewed

    Arch Toxicol   Vol. 16   page: 1-6   2005

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  53. *Nitric oxide and endothelial cellular senescence. Reviewed

    Hayashi T, Yano K, Matsui-Hirai H, Yokoo H, Hattori Y, Iguchi A

    Pharmacol Ther   Vol. 120 ( 3 ) page: 333-33   2008

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  54. Pitavastatin Shows Promise in Treatment of Patients With Type 2 Diabetes Reviewed

    Hayashi T, Iguchi A

    Review of Endocrinology   Vol. 1   page: 1-3   2008

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  55. Bowel incontinence is related to improvement in basic activities of daily living (BADL) in residents of long-term care health facilities for the elderly in Japan Reviewed

    Geriatrics Gerontology International   Vol. 5   page: 48-52   2005

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  56. Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus Reviewed

    Sasaki N, Yamashita T, Takaya T, Shinohara M, Shiraki R, Takeda M, Emoto N, Fukatsu A, Hayashi T, Ikemoto K, Nomura T, Yokoyama M, Hirata K, Kawashima S

    Arterioscler Thromb Vasc Biol   Vol. 28   page: 1068-1076   2008

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  57. Proposed Guideleins for Hypertriglyceridemia in Japan with non-HDL Cholesterol as the second Target Reviewed

    Simano H, Arai H, Hayashi T, Yamada N. et al

    J Atheroscler Thromb   Vol. 15   page: 116-121   2008

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  58. NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction. Reviewed

    Diabetes Obes Metab   Vol. 7   page: 334-343   2005

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  59. The treadmill exercise-tolerance test is useful for the prediction and prevention of ischemic coronary events in elderly diabetics Reviewed

    J Diabetes Complications   Vol. 19   page: 264-8   2005

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  60. Nitric oxide: inhibitory effects on endothelial cell calcium signaling, prostaglandin I2 production and nitric oxide synthase expression. Reviewed

    Hayashi T, Iguchi A.

    Cardiovasc Res   Vol. 62   page: 194-201   2004

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  61. *l-Citrulline and l-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits. Reviewed

    Proc Natl Acad Sci U S A.   Vol. 102   page: 13681-6   2005

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    The objective of this study was to evaluate the influence of ingested l-arginine, l-citrulline, and antioxidants (vitamins C and E) on the progression of atherosclerosis in rabbits fed a high-cholesterol diet. The fatty diet caused a marked impairment of endothelium-dependent vasorelaxation in isolated thoracic aorta and blood flow in rabbit ear artery in vivo, the development of atheromatous lesions and increased superoxide anion production in thoracic aorta, and increased oxidation-sensitive gene expression [Elk-1 and phosphorylated cAMP response element-binding protein]. Rabbits were treated orally for 12 weeks with l-arginine, l-citrulline, and/or antioxidants. l-arginine plus l-citrulline, either alone or in combination with antioxidants, caused a marked improvement in endothelium-dependent vasorelaxation and blood flow, dramatic regression in atheromatous lesions, and decrease in superoxide production and oxidation-sensitive gene expression. These therapeutic effects were associated with concomitant increases in aortic endothelial NO synthase expression and plasma NO(2)(-)+NO(3)(-) and cGMP levels. These observations indicate that ingestion of certain NO-boosting substances, including l-arginine, l-citrulline, and antioxidants, can abrogate the state of oxidative stress and reverse the progression of atherosclerosis. This approach may have clinical utility in the treatment of atherosclerosis in humans.

  62. Selective iNOS inhibitor, ONO1714 successfully retards the development of high-cholesterol diet induced atherosclerosis by novel mechanism. Reviewed

    Atherosclerosis   Vol. 187   page: 316-324   2006

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  63. *Modulating role of estradiol on arginase II expression in hyper-lipidemic rabbits as an atheroprotective mechanism. Reviewed

    Proc Natl Acad Sci U S A.   Vol. 103   page: 10485-90   2006

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    We evaluated the effects of a 0.5% cholesterol-enriched diet (HCD) on nitric-oxide synthase (NOS) and arginase expression and the modulating role of 17beta-estradiol (E(2)) on this phenomenon. Thirty oopherectomized rabbits were divided into three groups and treated for 15 weeks. Group I received normal chow; group II, HCD; and group III, HCD plus E(2) pellets. Animals in group II showed an increase in plasma lipids, and they demonstrated atheromatous lesions as well as expression of arginase I and II accompanied by a significant number of BrdU-positive cells in endothelial cells and intimal muscle cells, suggestive of an increase in cellular proliferation. There was significant expression of inducible NOS and increased staining of nitrotyrosine-positive areas. These were not observed in group I animals. In both groups, E(2) levels were low. In group III animals, E(2) supplementation led to a decrease in atheromatous lesions and BrdU-positive cells and reduced expression of both inducible NOS and arginase I and II accompanied by a decrease in nitrotyrosine staining. E(2) levels were increased. Our results suggest that E(2) was responsible for these effects, despite the animals being hyperlipidemic, similar to those in group II. Because arginase is responsible for cell proliferation by converting l-arginine to polyamines, our results indicate that expression of arginase may play an important role in cellular proliferation in atherosclerosis, and inhibition of arginase expression by E(2) may be another potential mechanism in attenuating atherogenesis.

  64. *Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes. Reviewed

    Proc Natl Acad Sci USA   Vol. 103   page: 17018-23   2006

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    Senescence may contribute to the pathogenesis of atherosclerosis. Although the bioavailability of nitric oxide (NO) is limited in senescence, the effect of NO on senescence and its relationship to cardiovascular risk factors have not been investigated fully. We studied these factors by investigating senescence-associated beta-galactosidase (SA-beta-gal) and human telomerase activity in human umbilical venous endothelial cells (HUVECs). Treatment with NO donor (Z)-1-[2-(2-aminoethyl)-N-(2-aminoethyl)amino]diazen-1-ium-1,2-diolate (DETA-NO) and transfection with endothelial NO synthase (eNOS) into HUVECs each decreased the number of SA-beta-gal positive cells and increased telomerase activity. The NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) abolished the effect of eNOS transfection. The physiological concentration of 17beta-estradiol activated hTERT, decreased SA-beta-gal-positive cells, and caused cell proliferation. However, ICI 182780, an estrogen receptor-specific antagonist, and L-NAME each inhibited these effects. Finally, we investigated the effect of NO bioavailability on high glucose-promoted cellular senescence of HUVECs. Inhibition by eNOS transfection of this cellular senescence under high glucose conditions was less pronounced. Treatment with L-arginine or L-citrulline of eNOS-transfected cells partially inhibited, and combination of L-arginine and L-citrulline with antioxidants strongly prevented, high glucose-induced cellular senescence. These data demonstrate that NO can prevent endothelial senescence, thereby contributing to the anti-senile action of estrogen. The ingestion of NO-boosting substances, including L-arginine, L-citrulline, and antioxidants, can delay endothelial senescence under high glucose. We suggest that the delay in endothelial senescence through NO and/or eNOS activation may have clinical utility in the treatment of atherosclerosis in the elderly.

  65. Nitric oxide (NO) is a new clinical biomarker of survival in the elderly patients and its efficacy might be nearly equal to albumin. Reviewed

    Nitric Oxide   Vol. 16   page: 157-63   2007

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  66. Beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes. Reviewed

    Life Sciences   Vol. 80   page: 592-599   2007

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  67. 17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease. Reviewed

    J Pharmacol Exp Ther   Vol. 320   page: 591-8   2007

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  68. High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase: implications for atherosclerosis. Reviewed

    Biochim Biophys Acta   Vol. 1772   page: 364-72   2007

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  69. Possible Usefulness of Apocynin, an NADPH Oxidase Inhibitor, for Nitrate Tolerance: Prevention from Nitric Oxide Donor-Induced Endothelial Cell Abnormalities. Reviewed

    Am J Physiol Heart Circ Physiol.   Vol. 293   page: H790-7   2007

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  70. Risks of CHD identified by different criteria of metabolic syndrome and related changes of adipocytokines in elderly post menopausal women. Reviewed

    JDiabetes and its Complication   Vol. 21   page: 315-9   2007

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  71. A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits Reviewed

    Hayashi T,

    Free Radic Biol Med   Vol. 35   page: 102-113   2003

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  72. Nitric oxide (NO) metabolites are associated with survival in older patients. Reviewed

    J Am Geriatr Soc   Vol. 55   page: 1398-403   2007

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  73. A Specific Role for eNOS-Derived Reactive Oxygen Species in Atherosclerosis Progression. Reviewed

    Takaya T, Hirata KI, Yamashita T, Fukatsu A, Hayashi T, Alp NJ, Channon KM, Yokoyama M, Kawashima S.

    Arterioscler Thromb Vasc Biol.   Vol. 27   page: 1632-1637   2007

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  74. Pitavastatin: efficacy and safety in intensive lipid lowering Invited Reviewed

    Hayashi T, Yokote K, Saito Y, Iguchi A

    Expert Opin Pharmacother.   Vol. 8   page: 2315-2327   2007

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  75. Importance of lipid levels in elderly diabetic individuals: baseline characteristics and 1-year survey of cardiovascular events Reviewed

    Hayashi T, Kawashima S, Itoh H, Yamada N, Sone H, Watanabe H, Hattori Y, Ohrui T, Yoshizumi M, Yokote K, Kubota K, Nomura H, Umegaki H, Iguchi A; Japan CDM group.

    Circulation J.   Vol. 72 ( 2 ) page: 218-225   2008

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  76. 17beta-estradiol inhibits NADPH oxidase activity through the regulation of p47phox mRNA and protein expression in THP-1 cells Reviewed

    Hayashi T, Iguchi A.et al.

    Biochim Biophys Acta   Vol. 1640   page: 113-8   2003

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  77. Standardization of plasma brain natriuretic peptide concentrations in older Japanese-relationship to latent renal dysfunction and ischemic heart disease. Reviewed

    Hayashi T, Nomura H. et al.

    J Am Geriatr Soc.   Vol. 50   page: 1504-9   2002

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  78. Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects. Reviewed

    Hayashi T, Iguchi A.et al.

    Diabetes Care   Vol. 26   page: 285-289   2003

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  79. Estriol retards and stabilizes atherosclerosis through an NO-mediated system. Reviewed

    Hayashi T, Iguchi A.et al.

    . Life Sci.   Vol. 24   page: 31-42   2002

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  80. Concomitant production of nitric oxide and superoxide in human macrophages. Reviewed

    Hayashi T, Iguchi A.et al.

    Biochem Biophys Res Commun   Vol. 310   page: 367-370   2003

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  81. Sarpogrelate HCl, a selective 5-HT2A antagonist, retards the progression of atherosclerosis through a novel mechanism Reviewed

    Hayashi T, Iguchi A.et al.

    Atherosclerosis   Vol. 168   page: 23-31   2003

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  82. The long-term effect of estriol on endothelial function and bone mineral density in octogenarian women. Reviewed

    Hayashi T. et al.

    J Am Geriatr Soc.   Vol. 50   page: 777-778   2002

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  83. Estrogen prevents destabilization of endothelial nitric oxide synthase mRNA induced by tumor necrosis factor alpha through estrogen receptor mediated system. Reviewed

    Hayashi T, Iguchi A.et al.

    Life Sci   Vol. 69   page: 1651-60   2001

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  84. Anti-atherosclerotic effect of beta-blocker with nitric oxide-releasing action on the severe atherosclerosis. Reviewed

    Hayashi T et al.

    J Cardiovasc Pharmacol   Vol. 39   page: 298-309   2002

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  85. Endothelium-dependent hyperpolarization and relaxation in mesenteric arteries of middle-aged rats: influence of oestrogen. Reviewed

    Sakuma I, Hayashi T.et al.

    Br J Pharmacol   Vol. 135   page: 48-54   2002

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  86. Temporal effects of 17beta-estradiol on caveolin-1 mRNA and protein in bovine aortic endothelial cells Reviewed

    Hayashi T, Iguchi A.et al.

    Am J Physiol Heart Circ Physiol   Vol. 281   page: 1327-33   2001

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  87. Up-regulation of endothelial nitric oxide synthase through beta(2)-adrenergic receptor--the role of a beta-blocker with NO-releasing action. Reviewed

    Hayashi T, Iguchi A et al.

    Biochem Biophys Res Commun   Vol. 280   page: 589-594   2001

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  88. HMG-CoA reductase inhibitor stabilizes rabbit atheroma by increasing basal NO and decreasing superoxide Reviewed

    Hayashi T, Iguchi A et al.

    Am J Physiol Heart Circ Physiol   Vol. 281   page: H75-83   2001

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  89. Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days. Reviewed

    Hayashi T, Iguchi A.et al.

    Circulation   Vol. 104   page: 376-9   2001

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  90. Myosin light-chain kinase regulates endothelial calcium entry and endothelium-dependent vasodilation Reviewed

    Watanabe H, Hayashi T. et al.

    FASEB J   Vol. 15   page: 282-4   2001

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  91. Expression of inducible nitric oxide synthase and Fas/Fas ligand correlates with the incidence of apoptotic cell death in atheromatous plaques of human coronary arteries. Reviewed

    Hayashi T, Iguchi A.et al.

    Nitric Oxide   Vol. 4   page: 561-571   2000

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  92. Phenanthraquinone inhibits eNOS activity and suppresses vasorelaxation. Reviewed

    Kumagai Y, Hayashi T et al.

    Am J Physiol Regul Integr Comp Physiol   Vol. 281   page: R25-30   2001

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  93. Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in beta-amyloid protein-stimulated J774 cells. Reviewed

    Hayashi T, Iguchi A.et al.

    Eur J Pharmacol.   Vol. 408   page: 137-141   2000

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  94. A HMG-CoA reductase inhibitor possesses a potent anti-atherosclerotic effect other than serum lipid lowering effects--the relevance of endothelial nitric oxide synthase and superoxide anion scavenging action. Reviewed

    Hayashi T, Iguchi A.et al.

    Atherosclerosis.   Vol. 155   page: 347-57   2001

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  95. Physiological concentration of 17beta-estradiol retards the progression of severe atherosclerosis induced by a high-cholesterol diet plus balloon catheter injury: role of NO Reviewed

    Hayashi T, Iguchi A. et al.

    Arterioscler Thromb Vasc Biol.   Vol. 20   page: 1613-21   2000

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  96. Estriol (E3) replacement improves endothelial function and bone mineral density in very elderly women. Reviewed

    Hayashi T, Iguchi A et al.

    J Gerontol A Biol Sci Med Sci.   Vol. 55   page: 183-190   2000

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  97. Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen: the possible role of nitric oxide. Reviewed

    Hayashi T, Gautam C, Naito M, Funaki C, Iguchi A.

    Arterioscler Thromb Vasc Biol   Vol. 20   page: 782-792   2000

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  98. A. HMG-CoA reductase inhibitor improved regression of atherosclerosis in the rabbit aorta without affecting serum lipid levels: possible relevance of up-regulation of endothelial NO synthase mRNA. Reviewed

    Hayashi Toshio, Kuzuya Masafumi, Funaki Chiaki, Naito Michitaka, Iguchi Akihisa

    Biochem Biophys Res Commun   Vol. 259   page: 414-419   1999

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  99. Physiological concentration of 17-β-estradiol inhibits the effect of inducible nitric oxide synthase in macrophage cell line : J774 by receptor mediated system. Reviewed

    Hayashi T, Gautam C, Funaki C, Iguchi A.

    Journal of Cardiovascular Pharmacology   Vol. 31   page: 292-298   1998

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  100. Endothelium-dependent relaxation of rabbit atherosclerotic aorta was not restored by control of hyperlipidemia: the possible role of peroxynitrite (ONOO(-)). Reviewed

    Hayashi Toshio, Kuzuya Masafumi, Funaki Chiaki, Naito Michitaka, Iguchi Akihisa

    Atherosclerosis   Vol. 147   page: 349-363   1999

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  101. Inducible Nitric Oxide Synthase is expressed in atherosclerotic lesions of cholesterol-fed rabbits Reviewed

    Hayashi T, Iguchi A.

    Atherosclerosis   Vol. 128   page: 39-46   1997

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  102. The β adrenoreceptor antagonist, NIPRADILOL, preserves the endothelial nitric oxide response in atherosclerotic vessels of rabbit. Reviewed

    Hayashi T

    Life Sciences   Vol. 61   page: 1379-1387   1997

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  103. Endothelial constitutive nitric oxide synthase exists in airways and diesel exhaust particles inhibit the effect of nitric oxide. Reviewed

    Mutou Emiko, Hayashi T, ISHIkawa T

    Life Sciences   Vol. 92   page: 1563-1570   1996

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  104. Centrtal administration of a nitric oxide synthase inhibitor impairs spatial memory in spontaneous hypertensive rats. Reviewed

    Suzuki Y, Hayashi T, Naito M, Kuzuya M

    Neuroscience Letters   Vol. 207   page: 105-108   1996

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  105. Gender differences in atherosclerosis formation : Possible role of nitric oxide. Reviewed

    Hayashi T, Gautam C, Funaki C, Iguchi A.

    Journal of Cardiovascular Pharmacology   Vol. 26   page: 792-802   1995

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  106. Physiological concentration of estradiol inhibits polymorphonuclear leukocyte chemotaxis via a receptor mediated system Reviewed

    Hayashi Toshio, Kuzuya Masafumi, Funaki Chiaki, Naito Michitaka, Iguchi Akihisa

    Life Sciences   Vol. 25   page: 2247-2253   1995

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  107. Estrogen increases endothelial nitric oxide by a receptor mediated system. Reviewed

    Hayashi Toshio, Kuzuya Masafumi, Funaki Chiaki, Naito Michitaka, Iguchi Akihisa

    Biochemical and Biophysical Research Communication   Vol. 214   page: 847-855   1995

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  108. Biphasic effect of estrogen on neuronal constitutive nitric oxide synthase via Ca2+-calmodulin dependent mechanism. Reviewed

    Hayashi T, Ishikawa T, Funaki C, Iguchi A.

    Biochem Biophys Res Comm   Vol. 203   page: 1013-1019   1994

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  109. Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits : Implications for atherosclerosis. Reviewed

    Hayashi Toshio, John M Fukuto, Gautam Chaudhuri, Louis J Ignarro

    Proc Natl Acad Sci USA   Vol. 89   page: 11259-11263   1992

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    Estradiol is known to exert a protective effect against the development of atherosclerosis, but the mechanism of this hormonal action is unknown. One of the early events in the development of atherosclerosis is the adhesion of macrophages to endothelial cells, and nitric oxide (NO) inhibits this process. We show that basal release of NO is greater with endothelium-intact aortic rings from female rabbits than those from males. Oophorectomy diminishes both circulating estradiol concentration and basal release of NO to levels seen in male rabbits. These data establish that basal NO release from endothelium-intact aortic rings depends on circulating estradiol concentration and offer an explanation for the protective effect of estradiol against the development of atherosclerosis.

  110. HDL does not promote cholesterol efflux from macrophages of hypercholesterolemic rabbit: efflux differences between species Reviewed

    Hayashi Toshio, Kuzuya Masafumi, Funaki Chiaki, Naito Michitaka, Kuzuya Fumio

    Artery   Vol. 19   page: 184-198   1992

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  111. Nocturnal blood pressure monitored by ambulatory blood pressure measurement in elderly hypertensive patients Reviewed

    Hayashi Toshio, Kuzuya Masafumi, Funaki Chiaki, Kuzuya Fumio

    Intern Med   Vol. 31   page: 441-6   1992

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  112. Low level hyperlipidemia impairs endothelium-dependent relaxation of porcine coronary arteries by two mechanisms. Functional change in endothelium and impairment of endothelium-dependent relaxation by two mediators. Reviewed

    Hayashi Toshio, Kuzuya Masafumi, Funaki Chiaki, Kuzuya Fumio

    Atherosclerosis   Vol. 87   page: 23-38   1991

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  113. Role of platelet secretory products in modified lipoprotein metabolism in macrophages Reviewed

    Hayashi Toshio, Kuzuya Masafumi, Funaki Chiaki, Kuzuya Fumio

    Artery   Vol. 16   page: 248-262   1989

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  114. Beta-migrating very low density lipoprotein attenuates endothelium-dependent relaxation in rabbit atherosclerotic aortas Reviewed

    Hayashi Toshio, Kuzuya Masafumi, Funaki Chiaki, Kuzuya Fumio

    Blood Vessels   Vol. 26   page: 290-299   1989

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  115. Combining Potent Statin Therapy with Other Drugs to Optimize Simultaneous Cardiovascular and Metabolic Benefits while Minimizing Adverse Events

    Koh Kwang Kon, Sakuma Ichiro, Shimada Kazunori, Hayashi Toshio, Quon Michael J.

    KOREAN CIRCULATION JOURNAL   Vol. 47 ( 4 ) page: 432-439   2017.7

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    DOI: 10.4070/kcj.2016.0406

    Web of Science

    PubMed

  116. Gene transfer of endothelial NO synthase, but not eNOS plus inducible NOS, regressed atherosclerosis in rabbits. Reviewed

    Hayashi T, Iguchi A.

      Vol. 61   page: 339-351   2004

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    The effects of in vivo gene transfer of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) genes on severe atherosclerosis were investigated in rabbits. The recombinant adenoviruses, Ad.eNOS and Ad.iNOS, which respectively express eNOS and iNOS, were constructed. Atherosclerosis was induced by a balloon injury followed by a high cholesterol diet for 12 weeks. The rabbits were divided into six groups: Gp cont (no treatment); Gp null (adenovirus sham-infected); Gp eNOS (Ad.eNOS); Gp iNOS (Ad.iNOS); Gp e+i (Ad.eNOS plus Ad.iNOS); and Gp heNOS (a high dose of Ad.eNOS). Examinations were carried out 7 days after gene transfer. Plasma lipid levels were not significantly changed, but transfection with Ad.eNOS (Gp eNOS and Gp heNOS) decreased the tissue cholesterol concentration and regressed atherosclerotic lesions. Vessels treated with Ad.iNOS (Gp iNOS and Gp e+i) showed iNOS staining in the atheroma, and slight staining at other parts of the vessels; those treated with Ad.eNOS showed eNOS staining in the endothelium and subintima, and slight staining at other parts. Ad.eNOS transfection, but not Ad.iNOS or Ad.eNOS+Ad.iNOS transfection, improved the impaired aortic endothelium-dependent relaxation (EDR) and basal NO-dependent response, increased tissue cyclic GMP (cGMP), and decreased the release of O2- from vessels. eNOS treatment showed a decreasing tendency in regions with peroxynitrite staining, MMP1 staining, and suspected apoptosis. In conclusion, in vivo gene transfer of eNOS, but not iNOS or eNOS plus iNOS, regressed atherosclerosis. The relations among NO, O2-, and peroxynitrite may be critical, and lipid resorption from the lesions may be responsible for the regression.

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Books 12

  1. Amino acid biology in the post-genome era. New perspectives

    Toshio Hayashi( Role: Joint author)

    Springer JAPAN  2017 

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    Language:English Book type:Scholarly book

  2. Risk Factor of Caridiovascular Diseases:Primary Prevention: Chapter 2 Aging

    Hayashi T. ( Role: Sole author)

    Elsevier  2013 

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    Language:English

  3. Risk Factor of Caridiovascular Diseases:Primary Prevention: Chapter 3 Gender

    Hayashi T.( Role: Sole author)

    Elsevier  2013 

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    Language:English

  4. 疾患からみた臨床薬理学 改訂3版  骨粗鬆症

    林 登志雄( Role: Joint author)

    じほう  2011.3 

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    Language:Japanese

    骨粗鬆症

  5. Nitric Oxide: Biology and Pathobiology, 2nd EdnFree Radicals as Atherosclerotic Risk in Relation to Nitric Oxide

    Louis J Ignarro Edition( Role: Joint author)

    Elsevier  2010.3 

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    Language:English

    Free Radicals as Atherosclerotic Risk in Relation to Nitric Oxide

  6. これからの老年医学  中国語版

    井口昭久監修, 林 登志雄、余 澤雲編( Role: Joint author)

    昆明医学中央出版/名大出版社  2009 

  7. 脂質代謝異常―高脂血症、低脂血症-閉経後高脂血症の臨床的特徴とその治療-

    林 登志雄( Role: Joint author)

    日本臨床社  2008 

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    Language:Japanese

  8. 酸化ストレスと心血管病  ー酸化ストレスとエストロゲンー

    林 登志雄( Role: Joint author)

    日本医学出版  2008 

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    Language:Japanese

  9. ベッドサイドの高齢者の診かた  尿失禁

    林 登志雄( Role: Joint author)

    南山堂  2008 

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    Language:Japanese

  10. 老年医学テキスト  日本老年医学会編 老年病の臨床ー高齢者の主要な疾患ー

    林 登志雄( Role: Joint author)

    Medical View 社  2008 

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    Language:Japanese

  11. 症例に学ぶ高脂血症治療―専門医の見るポイント :高齢者高脂血症の治療

    林 登志雄( Role: Joint author)

    南山堂  2007 

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    Language:Japanese

  12. 臨床分子内分泌学 心血管内分泌代謝 : 病態と疾患からみたNO: 糖尿病性心血管病とNO

    林 登志雄( Role: Joint author)

    Medical View 社  2007 

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    Language:Japanese

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Presentations 14

  1. Clinical Approach for Atherosclerosis in Elderly International conference

    The 20th Korea Lipid and Atherosclerosis Society Annual Meeting:Invited Plenary Lecture 

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    Event date: 2010.9

    Language:English   Presentation type:Oral presentation (invited, special)  

  2. Interactions of glucose and insulin in regulation of replicative and stress-induced endothelial senescence ―The relationship between telomere and nitric oxide― International conference

    America's Gerontology Society 62nd Annual Scientific Meeting: Late Breaker Session 

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    Event date: 2009.11

    Language:English   Presentation type:Oral presentation (general)  

  3. Low HDL-cholesterol is associated with the risk of stroke in elderly diabetic individuals International conference

    19th IAGG World Congress of Gerontology and GeriatricsOral mini-symposium 

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    Event date: 2009.7

    Language:English   Presentation type:Oral presentation (general)  

  4. Nitric oxide anendothelial cell senescence International conference

    AVDRC Symposium on “Vascular Aging and Atherosclerosis"(Invited Special Lecture) 

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    Event date: 2008.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  5. Vascular senescence and NO in asian elderly International conference

    Invited speech at Symposium of Konkuk University 

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    Event date: 2008.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  6. HDL cholesterol is more important than glucose control in the prevention of atherosclerotic diseases in Asian diabetic elderly International conference

    5th Congress of European Union Geriatric Medicine Society (Symposium 4) 

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    Event date: 2008.9

    Language:English   Presentation type:Oral presentation (general)  

  7. The Healthy Longevity in Japan International conference

    The 8th Asia/Oceania Regional Congress of Gerontology and Geriatric Symposium Symposium: Healthy Longevity 

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    Event date: 2007.10

    Language:English   Presentation type:Oral presentation (general)  

  8. Endocrinological Biomarker Representing the Risk of Metabolic Syndrome, Diabetes and Hyperlipidemia in Japan International conference

    The 8th Asia/Oceania Regional Congress of Gerontology and Geriatric Symposium Symposium:Future Attitude as Asian Geriatrics 

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    Event date: 2007.10

    Language:English   Presentation type:Oral presentation (general)  

  9. Atherosclerosis in Elderly International conference

    1st China-Japan Gerontology Meeting 

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    Event date: 2004.10

    Language:English   Presentation type:Oral presentation (invited, special)  

  10. The Investigation of NO and superoxide producing enzymes in endothelial cells and macrophages for various coronary risk factors. International conference

    The 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide 

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    Event date: 2004.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  11. To be or not to be: What are certified scientific findings in HRT? Shall we proceed? International conference

    XIIIth Internationa Symposium on Atherosclerosis: Workshop Postmenopausal Women and HRT 

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    Event date: 2003.9

    Language:English   Presentation type:Oral presentation (general)  

  12. Statins and Nitric Oxide International conference

    The 12th Korea Lipid and Atherosclerosis Society Annual Meeting: Invited Plenary Lecture 

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    Event date: 2002.9

    Language:English   Presentation type:Oral presentation (invited, special)  

  13. Estrogen and Atherosclerosis International conference

    XIIth Internationa Symposium on Atherosclerosis Symposium: Recent Progress in Atherosclerosis 

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    Event date: 2000.9

    Language:English   Presentation type:Oral presentation (general)  

  14. Estrogen and atherosclerosis-including viewpoints of lipid metabolism International conference

    18th World Congress of the International Union of Angiology Symposium:Endothelial function and Atherosclerosis 

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    Event date: 1998.9

    Language:English   Presentation type:Oral presentation (general)  

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Research Project for Joint Research, Competitive Funding, etc. 11

  1. 糖尿病の標準的治療の開発と均てん化

    2015.9 - 2017.3

    AMED 

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    Grant type:Competitive

  2. 凝固因子Xa阻害剤の糖尿病性血管障害に対する効果ー抗アテローム性硬化作用と抗老化作用の期待ー

    2015.4 - 2018.3

    企業からの受託研究 

  3. 日本人2型糖尿病患者における生活習慣介入の長期予後効果並びに死亡率とその危険因子に関する前向き研究(JDCS)

    2012.4 - 2015.3

    科学技術振興調整費 

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    Grant type:Competitive

  4. 食品成分の投与が動脈硬化及び血管老化の 進展抑制に 及ぼす影響に関する研究

    2011.8 - 2017.3

    企業からの受託研究 

  5. 原発性高脂血症に関する調査研究 

    2011.4

    科学技術振興調整費 

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    Grant type:Competitive

  6. 保健指導等を活用した総合的な糖尿病治療の年代別要因を踏まえた研究

    2011.4 - 2014.3

    科学技術振興調整費 

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    Grant type:Competitive

  7. 糖尿病患者における心血管イベント発症に関する後ろ向きコホートに関する研究(

    2009.4 - 2011.3

    科学技術振興調整費 

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    Grant type:Competitive

  8. 原発性高脂血症に関する調査研究

    2008.4 - 2011.3

    科学技術振興調整費 

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    Grant type:Competitive

  9. 食品成分の投与がNO産生機構に及ぼす影響に関する研究

    2007.5 - 2009.4

    企業からの受託研究 

  10. 各種高脂血症薬の糖尿病性心血管合併症発症進展抑制に向けた総合的研究

    2004.4 - 2007.3

    科学技術振興調整費 

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    Grant type:Competitive

  11. ストレスと老化、免疫

    2004.4 - 2007.3

    科学技術振興調整費 

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. 高齢者の健康維持を目的とした性差医療の実態と必要性の検討

    2017.4 - 2021.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  2. 血管老化と糖尿病性血管合併症の関連 -ヒトバイオマーカーの可能性-

    2017.4 - 2020.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  3. 内科学&老年学総合アプローチによるアジア女性健康長寿研究:更年期~後期高齢期まで

    2012.4 - 2016.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  4. 細胞老化制御による進行動脈硬化症退縮―本邦高齢者生活習慣病の新規治療法を目指して

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  5. 高齢女性の動脈硬化性疾患予防と健康長寿を目指すアジア老年医学研究

    2008.4 - 2012.3

    科学研究費補助金  基盤研究(B)

    林 登志雄

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  6. 細胞老化制御による進行動脈硬化症治療―本邦高齢者へのオーダーメイド治療を目指すー

    2009.4 - 2012.3

    科学研究費補助金  基盤研究(C)

    林 登志雄

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    Authorship:Principal investigator 

  7. 一酸化窒素、活性酸素制御を介する血管内分泌及び血管老化制御による動脈硬化退縮療法

    2007.4 - 2009.3

    科学研究費補助金  基盤研究(C)

    林 登志雄

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    Authorship:Principal investigator 

  8. ホルモン補充療法合併症発症の地域差要因解明のための海外学術調査

    2004.4 - 2007.3

    科学研究費補助金  基盤研究(B)

    林 登志雄

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Industrial property rights 1

  1. シトルリンまたはその塩およびアルギニンまたはその塩を有効成分として含有する、即効性アルギニン血中濃度上昇型経口剤

    林 登志雄、落合将之,森下幸治

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    Applicant:松田 譲

    Date applied:2007.10

    Patent/Registration no:整理番号2007P00056 国際特許分類A61K 31/198 

    Country of applicant:Foreign country  

    1)シトルリンまたはその塩およびアルギニンまたはその塩を有効成分として含有する、即効性アルギニン血中濃度上昇型経口剤。2)血流促進用である請求項1記載の経口剤。3)血流低下から生じる症状の予防または改善用である請求項1記載の経口剤。4)上記症状が肩凝り、冷え症、むくみおよび勃起不全より選ばれる少なくとも一つの症状の予防または改善用である請求項3記載の経口剤。5)血中アンモニア濃度の上昇抑制用である請求項1記載の経口剤。6)血中アンモニア濃度の上昇から生じる症状の予防または改善用である請求項1記載の経口剤。7)上記症状が運動後の筋疲労または疲労感の予防または改善用である6)記載の経口剤

 

Teaching Experience (Off-campus) 1

  1. 老年病と老化

    2006.4 - 2007.3 筑波大学)