Updated on 2022/07/03

写真a

 
HIRAYAMA, Masaaki
 
Organization
Graduate School of Medicine Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Associate professor

Degree 1

  1. 医学博士 ( 1993.1 ) 

Research Interests 8

  1. microbiota

  2. パーキンソン病

  3. 脳波

  4. 筋電図

  5. 神経伝導速度

  6. 音楽療法

  7. 食事性低血圧

  8. 起立性低血圧

Research Areas 5

  1. Others / Others  / neurophysiology

  2. Others / Others  / Neurology

  3. Others / Others  / electro neuro physiology

  4. Others / Others  / autonomic nervous system

  5. Life Science / Medical biochemistry  / 腸内細菌学

Current Research Project and SDGs 10

  1. パーキンソン病患者の酸化ストレス

  2. Aδ線維の伝導速度の加齢による影響、パーキンソン病の痛み(Aδおよび温度感覚閾値)

  3. 睡眠時無呼吸時の上気道の変化

  4. 睡眠時無呼吸患者の呼吸喚起応答および循環器応答

  5. 高齢者における空間認知障害

  6. パーキンソン病の音楽療法

  7. パーキンソン病の自律神経障害

  8. neural image of autonomic failure

  9. Meusurement of nerve conduction for patient with peripherul nerve dumage

  10. パーキンソン病の発症、進行への腸内細菌叢の関与

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Research History 4

  1. Nagoya University school of health science

    2010.9

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    Country:Japan

  2. Nagoya University   Innovative Research Center for Preventive Medical Engineering

    2010.4

  3. 講師

    2007.4

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    Country:Japan

  4. Nagoya University   department of neurology nagoya university school of medicine

    2007.4

Education 1

  1. Gifu University   Faculty of Medicine

    - 1984

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    Country: Japan

Professional Memberships 6

  1. 日本自律神経学会   評議員

    1995.4

  2. 日本臨床神経生理学会   脳波、筋電図専門医、指導医

    1989.6

  3. 日本リハビリテーション医学会   認定臨床医

    1988.4

  4. 日本神経学会   代議員

    1987.5

  5. 日本末梢神経学会   評議員

  6. 日本てんかん学会

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Awards 1

  1. 第8回学術集会優秀演題賞

    2020.11   日本難病医療ネットワーク学会   パーキンソン病患者における便秘の重症度とQuality of Life との関連

    土井智子、竹原君江、中西啓介、平山正昭、本田育美

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    Award type:Award from Japanese society, conference, symposium, etc. 

 

Papers 192

  1. Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson's disease

    Nishiwaki Hiroshi, Ito Mikako, Hamaguchi Tomonari, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Yoshida Takumi, Hanada Hiroyuki, Takeuchi Ichiro, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji

    NPJ PARKINSONS DISEASE   Vol. 8 ( 1 ) page: 65   2022.6

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  2. Altered gut microbiota in Parkinson's disease patients with motor complications Reviewed

    Takahashi Kai, Nishiwaki Hiroshi, Ito Mikako, Iwaoka Kazuhiro, Takahashi Kenta, Suzuki Yoshio, Taguchi Keita, Yamahara Kanako, Tsuboi Yoshio, Kashihara Kenichi, Hirayama Masaaki, Ohno Kinji, Maeda Tetsuya

    PARKINSONISM & RELATED DISORDERS   Vol. 95   page: 11 - 17   2022.2

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  3. Reply to the Letter to the Editor "The Microbiota in Parkinson's Disease: Ranking the Risk of Heart Disease". Reviewed

    Hirayama M, Ohno K

    Annals of nutrition & metabolism   Vol. 78 ( 2 ) page: 119 - 120   2022

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    Language:English  

    DOI: 10.1159/000521993

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  4. Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate Reviewed

    Hirayama Masaaki, Nishiwaki Hiroshi, Hamaguchi Tomonari, Ito Mikako, Ueyama Jun, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ohno Kinji

    PLOS ONE   Vol. 16 ( 11 )   2021.11

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    Authorship:Lead author, Corresponding author   Language:English  

    DOI: 10.1371/journal.pone.0260451

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  5. Parkinson's Disease and Gut Microbiota

    Hirayama Masaaki, Ohno Kinji

    ANNALS OF NUTRITION AND METABOLISM   Vol. 77 ( SUPPL 2 ) page: 28 - 35   2021.10

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  6. Hierarchical non-negative matrix factorization using clinical information for microbial communities. Reviewed

    BMC genomics   Vol. 22 ( 1 ) page: 104   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12864-021-07401-y

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  7. Impaired pain processing and its association with attention disturbance in patients with amyotrophic lateral sclerosis Reviewed

    Harada Yumiko, Nakamura Tomohiko, Suzuki Masashi, Ueda Masamichi, Hirayama Masaaki, Katsuno Masahisa

    NEUROLOGICAL SCIENCES     2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10072-020-05028-7

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  8. Difference in cardiovascular response during orthostatic stress in Parkinson's disease and multiple system atrophy

    Nakamura Tomohiko, Suzuki Masashi, Ueda Masamichi, Harada Yumiko, Hirayama Masaaki, Katsuno Masahisa

    JOURNAL OF NEURAL TRANSMISSION   Vol. 127 ( 10 ) page: 1377 - 1386   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00702-020-02241-8

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  9. Meta-Analysisof Gut Dysbiosis in Parkinson's Disease Reviewed

    Nishiwaki Hiroshi, Ito Mikako, Ishida Tomohiro, Hamaguchi Tomonari, Maeda Tetsuya, Kashihara Kenichi, Tsuboi Yoshio, Ueyama Jun, Shimamura Teppei, Mori Hiroshi, Kurokawa Ken, Katsuno Masahisa, Hirayama Masaaki, Ohno Kinji

    MOVEMENT DISORDERS   Vol. 35 ( 9 ) page: 1626 - 1635   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/mds.28119

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  10. Relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the medulla oblongata in multiple system atrophy Reviewed

    Suzuki Masashi, Nakamura Tomohiko, Hirayama Masaaki, Ueda Miki, Imai Eriko, Harada Yumiko, Katsuno Masahisa

    CLINICAL AUTONOMIC RESEARCH   Vol. 30 ( 3 ) page: 231-238   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10286-020-00675-4

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  11. Association of orthostatic blood pressure with the symptoms of orthostatic hypotension and cognitive impairment in patients with multiple system atrophy Reviewed

    Ueda Miki, Nakamura Tomohiko, Suzuki Masashi, Imai Eriko, Harada Yumiko, Hara Kazuhiro, Hirayama Masaaki, Katsuno Masahisa

    JOURNAL OF CLINICAL NEUROSCIENCE   Vol. 75   page: 40-44   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jocn.2020.03.040

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  12. Freeze-drying enables homogeneous and stable sample preparation for determination of fecal short-chain fatty acids. Reviewed

    Ueyama J, Oda M, Hirayama M, Sugitate K, Sakui N, Hamada R, Ito M, Saito I, Ohno K

    Analytical biochemistry   Vol. 589   page: 113508   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ab.2019.113508

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  13. Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder. Reviewed

    mSystems   Vol. 5 ( 6 )   2020

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/mSystems.00797-20

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  14. Impact of orthostatic hypotension on wheelchair use in patients with Parkinson's disease Reviewed

    Nakamura Tomohiko, Suzuki Masashi, Ueda Masamichi, Harada Yumiko, Hirayama Masaaki, Katsuno Masahisa

    JOURNAL OF NEURAL TRANSMISSION     page: 379 - 383   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00702-019-02127-4

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  15. Application of Skin Gas GC/MS Analysis for Prediction of the Severity Scale of Parkinson's Disease Reviewed

    Takao TSUDA, Tomoaki NONOME, Sae GOTO, Jun-ichi TAKEDA, Makoto TSUNODA, Masaaki HIRAYAMA, Kinji OHNO

    Chromatography   Vol. 40 ( 3 ) page: 149 - 155   2019.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.15583/jpchrom.2019.014

  16. ENIGMA: an enterotype-like unigram mixture model for microbial association analysis

    Abe Ko, Hirayama Masaaki, Ohno Kinji, Shimamura Teppei

    BMC GENOMICS   Vol. 20 ( Suppl 2 ) page: 191   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12864-019-5476-9

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  17. 【腸内細菌叢 健康と疾患を制御するエコシステム】(第2章)常在細菌叢と生理・病理 精神・神経系の制御、救急医療 パーキンソン病と腸内細菌叢

    大野 欽司, 平山 正昭

    実験医学   Vol. 37 ( 2 ) page: 299-302   2019.2

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  18. A latent allocation model for the analysis of microbial composition and disease.

    Abe K, Hirayama M, Ohno K, Shimamura T

    BMC bioinformatics   Vol. 19 ( Suppl 19 ) page: 519   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12859-018-2530-6

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  19. Quantification of hydrogen production by intestinal bacteria that are specifically dysregulated in Parkinson's disease. Reviewed

    Suzuki A, Ito M, Hamaguchi T, Mori H, Takeda Y, Baba R, Watanabe T, Kurokawa K, Asakawa S, Hirayama M, Ohno K

    PloS one   Vol. 13 ( 12 ) page: e0208313   2018.12

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    DOI: 10.1371/journal.pone.0208313

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  20. 【自律神経機能のみかた】瞳孔機能、薬物点眼試験のみかた

    平山 正昭

    神経内科   Vol. 89 ( 4 ) page: 342-348   2018.10

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  21. Randomized, double-blind, multicenter trial of hydrogen water for Parkinson's disease.

    Yoritaka A, Ohtsuka C, Maeda T, Hirayama M, Abe T, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Oda E, Ito M, Ohno K, Hattori N

    Movement disorders : official journal of the Movement Disorder Society     2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/mds.27472

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  22. Clinical and Imaging Features of Multiple System Atrophy: Challenges for an Early and Clinically Definitive Diagnosis.

    Watanabe H, Riku Y, Hara K, Kawabata K, Nakamura T, Ito M, Hirayama M, Yoshida M, Katsuno M, Sobue G

    Journal of movement disorders     2018.8

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    DOI: 10.14802/jmd.18020

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  23. 【腸内細菌と神経疾患】腸内細菌とParkinson病

    平山 正昭

    神経内科   Vol. 89 ( 2 ) page: 200-207   2018.8

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  24. Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease.

    Kawabata K, Watanabe H, Hara K, Bagarinao E, Yoneyama N, Ogura A, Imai K, Masuda M, Yokoi T, Ohdake R, Tanaka Y, Tsuboi T, Nakamura T, Hirayama M, Ito M, Atsuta N, Maesawa S, Naganawa S, Katsuno M, Sobue G

    Journal of neurology   Vol. 265 ( 3 ) page: 688-700   2018.3

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    DOI: 10.1007/s00415-018-8755-5

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  25. パーキンソン病のVisual View パーキンソン病の腸内細菌叢の問題

    平山 正昭

    Frontiers in Parkinson Disease   Vol. 11 ( 1 ) page: 22-26   2018.3

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  26. Restoration of a Conduction Block after the Long-term Treatment of CIDP with Anti-neurofascin 155 Antibodies: Follow-up of a Case over 23 Years.

    Koike H, Nishi R, Ikeda S, Kawagashira Y, Iijima M, Atsuta N, Nakamura T, Hirayama M, Ogata H, Yamasaki R, Kira JI, Katsuno M, Sobue G

    Internal medicine (Tokyo, Japan)     2018.2

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    DOI: 10.2169/internalmedicine.0455-17

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  27. Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson's disease

    Yoneyama Noritaka, Watanabe Hirohisa, Kawabata Kazuya, Bagarinao Epifanio, Hara Kazuhiro, Tsuboi Takashi, Tanaka Yasuhiro, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Hattori Tatsuya, Ito Mizuki, Atsuta Naoki, Nakamura Tomohiko, Hirayama Masaaki, Maesawa Satoshi, Katsuno Masahisa, Sobue Gen

    PLOS ONE   Vol. 13 ( 1 ) page: e0190072   2018.1

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    DOI: 10.1371/journal.pone.0190072

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  28. 【排尿の神経機構-その生理と病態】排尿障害をきたす疾患 パーキンソン病

    平山正昭

    Clinical Neuroscience   Vol. 36 ( 1 ) page: 76-77   2018.1

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  29. Inhalation of hydrogen gas elevates urinary 8-hydroxy-2 '-deoxyguanine in Parkinson's disease

    Hirayama Masaaki, Ito Mikako, Minato Tomomi, Yoritaka Asako, LeBaron Tyler W., Ohno Kinji

    MEDICAL GAS RESEARCH   Vol. 8 ( 4 ) page: 144-+   2018

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    DOI: 10.4103/2045-9912.248264

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  30. Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study

    Minato Tomomi, Maeda Tetsuya, Fujisawa Yoshiro, Tsuji Hirokazu, Nomoto Koji, Ohno Kinji, Hirayama Masaaki

    PLOS ONE   Vol. 12 ( 11 ) page: .   2017.11

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  31. 【腸内フローラと神経・精神疾患】腸内フローラと神経・精神疾患 パーキンソン病

    平山 正昭渡辺 宏久

    Clinical Neuroscience   Vol. 35 ( 11 ) page: 1330-32   2017.11

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  32. 神経科学の素朴な疑問 神経伝達物質の種類は終生変わらないのですか?(Q&A)

    平山 正昭

    Clinical Neuroscience   Vol. 35 ( 11 ) page: 1358   2017.11

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  33. Orthostatic hypotension in multiple system atrophy: Relation to symptoms and cognitive impairments

    Ueda M., Imai E., Suzuki M., Nakamura T., Hirayama M., Katsuno M.

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page: 922-922   2017.10

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    DOI: 10.1016/j.jns.2017.08.2593

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  34. Two-year follow-up study reveals that Gut dysbiosis predicts progression of Parkinson's disease

    Hirayama M., Minato T., Maeda T., Fujisawa Y., Hirokazu T., Nomoto K., Ohno K.

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page: 915-916   2017.10

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    DOI: 10.1016/j.jns.2017.08.2574

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  35. Relationship between cardiac parasympathetic dysfunction and atrophy of the medulla oblongata in multiple system atrophy

    Suzuki M., Nakamura T., Hirayama M., Ueda M., Imai E., Katsuno M.

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page: 921-921   2017.10

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    DOI: 10.1016/j.jns.2017.08.2590

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  36. Association between changes in visual evoked magnetic fields and non-motor features in Parkinson's disease

    Fujisawa Yoshiro, Minato Tomomi, Uemura Jun-ichi, Hoshiyama Minoru, Watanabe Hirohisa, Hirayama Masaaki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page: 147-155   2017.5

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    DOI: 10.18999/nagjms.79.2.147

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  37. Efficacy of a novel drug, zonisamide, in the modulation of oxidative stress in Parkinson's disease

    Hirayama Masaaki, Minato Tomomi, Maeda Tetsuya, Nakamura Tomohiko, Katsuno Masahisa

    NEUROLOGY AND CLINICAL NEUROSCIENCE   Vol. 5 ( 2 ) page: 49-54   2017.3

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    DOI: 10.1111/ncn3.12103

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  38. パーキンソン病の発症と病態進行に関わる腸内細菌叢の解明

    伊藤 美佳子, 大野 欽司, 平山 正昭, 鈴木 杏

    大和証券ヘルス財団研究業績集   ( 40 ) page: 81-82   2017.3

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  39. A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics (vol 16, 66, 2016)

    Yoritaka Asako, Abe Takashi, Ohtsuka Chigumi, Maeda Tetsuya, Hirayama Masaaki, Watanabe Hirohisa, Saiki Hidemoto, Oyama Genko, Fukae Jiro, Shimo Yasushi, Hatano Taku, Kawajiri Sumihiro, Okuma Yasuyuki, Machida Yutaka, Miwa Hideto, Suzuki Chikako, Kazama Asuka, Tomiyama Masahiko, Kihara Takeshi, Hirasawa Motoyuki, Shimura Hideki, Hattori Nobutaka

    BMC NEUROLOGY   Vol. 17 ( 1 ) page: 1-2   2017.2

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    DOI: 10.1186/s12883-017-0817-2

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  40. Cardiac parasympathetic dysfunction in the early phase of Parkinson's disease Reviewed

    Suzuki, M. Nakamura, T. Hirayama, M. Ueda, M. Katsuno, M. Sobue, G.

    J Neurol   Vol. 264 ( 2 ) page: 333-340   2017.2

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    DOI: 10.1007/s00415-016-8348-0

  41. Association between changes in visual evoked magnetic fields and non-motor features in Parkinson's disease Reviewed

    Fujisawa, Y. Minato, T. Uemura, J. I. Hoshiyama, M. Watanabe, H. Hirayama, M.

    Nagoya J Med Sci   Vol. 79 ( 2 ) page: 147-155   2017.2

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    DOI: 10.18999/nagjms.79.2.147

  42. 【対応が難しいParkinson病の症状-その評価と治療-】Parkinson病の自律神経障害

    平山正昭

    神経内科   Vol. 86 ( 2 ) page: 200-204   2017.2

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  43. Lower body mass index is associated with orthostatic hypotension in Parkinson's disease.

    Nakamura T, Suzuki M, Ueda M, Hirayama M, Katsuno M

    Journal of the neurological sciences   Vol. 372   page: 14 - 18   2017.1

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    DOI: 10.1016/j.jns.2016.11.027

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  44. Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice Reviewed

    Hasegawa, S. Ito, M. Fukami, M. Hashimoto, M. Hirayama, M. Ohno, K.

    Redox Rep   Vol. 22 ( 1 ) page: 26-34   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/13510002.2015.1135580

  45. Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study.

    Minato T, Maeda T, Fujisawa Y, Tsuji H, Nomoto K, Ohno K, Hirayama M

    PloS one   Vol. 12 ( 11 ) page: e0187307   2017

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    DOI: 10.1371/journal.pone.0187307

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  46. Association of leptin with orthostatic blood pressure changes in Parkinson's disease Reviewed

    Nakamura, T. Suzuki, M. Okada, A. Suzuki, J. Hasegawa, S. Koike, H. Hirayama, M. Katsuno, M. Sobue, G.

    Mov Disord   Vol. 31 ( 9 ) page: 1417-21   2016.9

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    INTRODUCTION: Leptin is involved in the regulation of blood pressure; however, no studies have evaluated the role of leptin in blood pressure changes during orthostatic stress in PD patients. The aim of this study was to determine whether plasma leptin levels influence orthostatic blood pressure changes in PD patients. METHODS: We enrolled 55 patients and 25 age-matched healthy controls in this study. Associations between head-up tilt test measurements and leptin levels were evaluated. RESULTS: Systolic blood pressure changes during the head-up tilt tests were strongly correlated with leptin levels at baseline and at a 60-degree head-up tilt in PD patients, but not in control subjects. Multiple regression analysis also demonstrated that leptin levels were associated with orthostatic blood pressure changes. CONCLUSION: These observations suggest that low leptin levels may be associated with orthostatic hypotension during the head-up tilt test in patients with PD. (c) 2016 International Parkinson and Movement Disorder Society.

    DOI: 10.1002/mds.26678

  47. Recovery function of somatosensory evoked brain response in patients with carpal tunnel syndrome: A magnetoencephalographic study Reviewed

    Iwatsuki, K. Yoshida, A. Shinohara, T. Nakano, T. Uemura, J. Goto, S. Hirayama, M. Hoshiyama, M. Hirata, H.

    Clin Neurophysiol   Vol. 127 ( 8 ) page: 2733-8   2016.8

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    DOI: 10.1016/j.clinph.2016.05.273

  48. 誌上ディベート パーキンソン病は腸管のα-シヌクレイン蓄積から始まる 「No」の立場から

    平山正昭

    Frontiers in Parkinson Disease   Vol. 9 ( 3 ) page: 125-7   2016.8

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  49. Expanding concept of clinical conditions and symptoms in multiple system atrophy Invited Reviewed

    Watanabe, H. Riku, Y. Nakamura, T. Hara, K. Ito, M. Hirayama, M. Yoshida, M. Katsuno, M. Sobue, G.

    Rinsho Shinkeigaku   Vol. 56 ( 7 ) page: 457-64   2016.7

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    Multiple system atrophy (MSA) is an adult-onset, progressive neurodegenerative disorder. MSA patients show various phenotypes during the course of their illness including parkinsonism, cerebellar ataxia, autonomic failure, and pyramidal signs. MSA is classified into the parkinsonian (MSA-P) or cerebellar (MSA-C) variant depending on the clinical motor phenotype at presentation. MSA-P and MSA-C are predominant in Western countries and Japan, respectively. The mean age at onset is 55 to 60 years. Prognosis ranges from 6 to 10 years, but some cases survive for more than 15 years. Early and severe autonomic failure is a poor prognostic factor. MSA patients sometimes present with isolated autonomic failure or motor symptoms/signs, and the median duration from onset to the concomitant appearance of motor and autonomic symptoms was approximately 2 years in our previous study. As the presence of the combination of motor and autonomic symptoms is essential for the current diagnostic criteria, early diagnosis is difficult when patients present with isolated autonomic failure or motor symptoms/signs. We experienced MSA patients who died before presentation of the motor symptoms/signs diagnostic for MSA (i.e., premotor MSA). Detection of the nature of autonomic failure consistent with MSA and identification of the dysfunctional anatomical sites may increase the probability of a diagnosis of premotor MSA. Dementia is another problem in MSA. Although dementia had been thought to be rare in MSA, frontal lobe dysfunction is observed frequently during the early course of the illness. Magnetic resonance imaging can show progressive cerebral atrophy in longstanding cases. More recently, MSA patients presenting with frontotemporal dementia preceding the presence of motor and autonomic manifestations diagnostic of MSA have been reported. Novel diagnostic criteria based on an expanding concept of the clinical conditions and symptoms of MSA will be needed for the development of disease-modifying therapies and better management.

    DOI: 10.5692/clinicalneurol.cn-000903

  50. 多系統萎縮症の病態と症候の広がり

    渡辺 宏久, 陸 雄一, 中村 友彦, 原 一洋, 伊藤 瑞規, 平山 正昭, 吉田 眞理, 勝野 雅央, 祖父江 元

    臨床神経学   Vol. 56 ( 7 ) page: 457-464   2016.7

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  51. A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics Reviewed

    Yoritaka, Asako Abe, Takashi Ohtsuka, Chigumi Maeda, Tetsuya Hirayama, Masaaki Watanabe, Hirohisa Saiki, Hidemoto Oyama, Genko Fukae, Jiro Shimo, Yasushi Hatano, Taku Kawajiri, Sumihiro Okuma, Yasuyuki Machida, Yutaka Miwa, Hideto Suzuki, Chikako Kazama, Asuka Tomiyama, Masahiko Kihara, Takeshi Hirasawa, Motoyuki Shimura, Hideki Hattori, Nobutaka

    BMC Neurology   Vol. 16   page: 66   2016.5

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    DOI: 10.1186/s12883-016-0589-0

  52. パーキンソン病治療UPDATE 早期・進行期の治療戦略 実践のためのQ&A(Q&A)

    平山正昭

    Clinic Magazine   Vol. 43 ( 5 ) page: 27-31   2016.5

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  53. Serum tyrosine-to-phenylalanine ratio is low in Parkinson's disease Reviewed

    Hirayama, M. Tsunoda, M. Yamamoto, M. Tsuda, T. Ohno, K.

    J Parkinsons Dis   Vol. 6 ( 2 ) page: 423-31   2016.4

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    BACKGROUND: Noninvasive biomarkers for Parkinson's disease (PD) are currently unavailable. OBJECTIVE: To search for a biomarker in sweat and serum unique to PD. METHODS: Sweat samples in 42 PD patients and 16 controls were analyzed using liquid chromatography/mass spectrometry (LC/MS). The principal component analysis (PCA) and the orthogonal projections to latent structures (OPLS) analysis were employed. Serum Phe and Tyr levels were determined using the HPLC-fluorescence detection system in 28 de novo PD patients, 52 L-Dopa-treated PD patients, and 27 controls. RESULTS: PCA and OPLS analyses of LC/MS of sweat samples revealed that Tyr, Phe, Leu (Ile), and Asp have high effect sizes to differentiate PD and controls. As Phe and Tyr are precursors of dopamine, we quantified the serum Phe and Tyr levels in de novo and treated PD patients, as well as in controls. Phe was high in de novo patients, but not in treated patients. In contrast, Tyr tended to be low in treated patients, but not in de novo patients. Tyr/Phe ratios were lower in both de novo and treated patients than in controls. The Tyr/Phe ratios were all higher than 0.82 in controls, whereas 49% of the de novo and treated patients had Tyr/Phe ratios less than 0.82. The low Tyr/Phe ratios were associated with male patients and low doses of entacapone. However, Tyr/Phe ratios were not different between male and female patients, and between patients with and without entacapone. CONCLUSIONS: The low serum Tyr/Phe ratio differentiates PD from controls with sensitivity = 0.49, specificity = 1.00, positive predictive value = 1.00, and negative predictive value = 0.40.

    DOI: 10.3233/JPD-150736

  54. A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics Reviewed

    Yoritaka, Asako Abe, Takashi Ohtsuka, Chigumi Maeda, Tetsuya Hirayama, Masaaki Watanabe, Hirohisa Saiki, Hidemoto Oyama, Genko Fukae, Jiro Shimo, Yasushi Hatano, Taku Kawajiri, Sumihiro Okuma, Yasuyuki Machida, Yutaka Miwa, Hideto Suzuki, Chikako Kazama, Asuka Tomiyama, Masahiko Kihara, Takeshi Hirasawa, Motoyuki Shimura, Hideki Hattori, Nobutaka

    BMC neurology   Vol. 16 ( 1 ) page: DOI   2016

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    DOI: 10.1186/s12883-016-0589-0

  55. Impaired Pain Processing Correlates with Cognitive Impairment in Parkinson's Disease Reviewed

    Okada, A. Nakamura, T. Suzuki, J. Suzuki, M. Hirayama, M. Katsuno, M. Sobue, G.

    Intern Med   Vol. 55 ( 21 ) page: 3113-3118   2016

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    DOI: 10.2169/internalmedicine.55.7067

  56. Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson's Disease. Reviewed

    Hasegawa S, Goto S, Tsuji H, Okuno T, Asahara T, Nomoto K, Shibata A, Fujisawa Y, Minato T, Okamoto A, Ohno K, Hirayama M.

    PloS one.   Vol. 10 ( 11 ) page: e0142164   2015.11

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  57. Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles. Reviewed

    Ichihara M, Sobue S, Ito M, Ito M, Hirayama M, Ohno K.

    Medical gas research.     2015.10

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    DOI: 10.1186/s13618-015-0035-1

  58. 脊髄サルコイドーシスに症候性筋サルコイドーシスを合併した1例 67Gaシンチグラフィーを用いた活動性の把握 Reviewed

    山田 晋一郎, 中西 浩隆, 平山 正昭, 勝野 雅央, 祖父江 元

    臨床神経学   Vol. 55 ( 9 ) page: 665-668   2015.9

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  59. Characteristic laryngoscopic findings in Parkinson's disease patients after subthalamic nucleus deep brain stimulation and its correlation with voice disorder.

    Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Yoneyama N, Hara K, Ito M, Hirayama M, Yamamoto M, Fujimoto Y, Kajita Y, Wakabayashi T, Sobue G.

    J Neural Transm (Vienna).     2015.8

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    DOI: 10.1007/s00702-015-1436-y

  60. Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation Reviewed

    Tsuboi, T. Watanabe, H. Tanaka, Y. Ohdake, R. Yoneyama, N. Hara, K. Nakamura, R. Watanabe, H. Senda, J. Atsuta, N. Ito, M. Hirayama, M. Yamamoto, M. Fujimoto, Y. Kajita, Y. Wakabayashi, T. Sobue, G.

    J Neurol Neurosurg Psychiatry   Vol. 86 ( 8 ) page: 856-64   2015.8

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    OBJECTIVES: To elucidate the phenotypes and pathophysiology of speech and voice disorders in Parkinson's disease (PD) with subthalamic nucleus deep brain stimulation (STN-DBS). METHODS: We conducted a cross-sectional study on 76 PD patients treated with bilateral STN-DBS (PD-DBS) and 33 medically treated PD patients (PD-Med). Speech and voice functions, electrode positions, motor function and cognitive function were comprehensively assessed. Moreover, speech and voice functions were compared between the on-stimulation and off-stimulation conditions in 42 PD-DBS patients. RESULTS: Speech and voice disorders in PD-DBS patients were significantly worse than those in PD-Med patients. Factor analysis and subsequent cluster analysis classified PD-DBS patients into five clusters: relatively good speech and voice function type, 25%; stuttering type, 24%; breathy voice type, 16%; strained voice type, 18%; and spastic dysarthria type, 17%. STN-DBS ameliorated voice tremor or low volume; however, it deteriorated the overall speech intelligibility in most patients. Breathy voice did not show significant changes and stuttering exhibited slight improvement after stopping stimulation. In contrast, patients with strained voice type or spastic dysarthria type showed a greater improvement after stopping stimulation. Spastic dysarthria type patients showed speech disorders similar to spastic dysarthria, which is associated with bilateral upper motor neuron involvement. Strained voice type and spastic dysarthria type appeared to be related to current diffusion to the corticobulbar fibres. CONCLUSIONS: Stuttering and breathy voice can be aggravated by STN-DBS, but are mainly due to aging or PD itself. Strained voice and spastic dysarthria are considered corticobulbar side effects.

    DOI: 10.1136/jnnp-2014-308043

  61. [67Ga scintigraphy as a therapeutic marker for spinal cord and muscular sarcoidosis: A case report]

    Yamada S, Nakanishi H, Hirayama M, Katsuno M, Sobue G.

    Rinsho shinkeigaku = Clinical neurology.     2015.7

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    DOI: 10.5692/clinicalneurol.cn-000738

  62. Impaired peripheral vasoconstrictor response to orthostatic stress in patients with multiple system atrophy.

    Suzuki J, Nakamura T, Hirayama M, Mizutani Y, Okada A, Ito M, Watanabe H, Sobue G.

    Parkinsonism & related disorders.     2015.6

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    DOI: 10.1016/j.parkreldis.2015.05.023

  63. 脳磁図を用いた手根管症候群における脳皮質の変化の検証

    岩月 克之, 寶珠山 稔, 上村 純一, 平山 正昭, 平田 仁

    日本手外科学会雑誌   Vol. 32 ( 1 ) page: 1-4-15   2015.4

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  64. Noninvasive monitoring of plasma l-dopa concentrations using sweat samples in Parkinson's disease Reviewed

    Tsunoda, M. Hirayama, M. Tsuda, T. Ohno, K.

    Clin Chim Acta   Vol. 442C   page: 52-55   2015.1

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    DOI: 10.1016/j.cca.2014.12.032

  65. 【自律神経系の最新情報】 自律神経系の病態と治療 パーキンソン病

    平山 正昭

    Clinical Neuroscience   Vol. 32 ( 12 ) page: 1411-1413   2014.12

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  66. Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation Reviewed

    Tsuboi, T. Watanabe, H. Tanaka, Y. Ohdake, R. Yoneyama, N. Hara, K. Nakamura, R. Watanabe, H. Senda, J. Atsuta, N. Ito, M. Hirayama, M. Yamamoto, M. Fujimoto, Y. Kajita, Y. Wakabayashi, T. Sobue, G.

    Journal of neurology, neurosurgery, and psychiatry     2014.10

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    DOI: 10.1136/jnnp-2014-308043

  67. Disinhibitory shift of recovery curve of somatosensory-evoked response in elderly: A magnetoencephalographic study Reviewed

    Goto, S. Fujisawa, Y. Uemura, J. I. Yamada, S. Hoshiyama, M. Hirayama, M.

    Clin Neurophysiol     2014.9

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    DOI: 10.1016/j.clinph.2014.09.018

  68. Hyposmia and cardiovascular dysautonomia correlatively appear in early-stage Parkinson's disease Reviewed

    Mizutani, Y. Nakamura, T. Okada, A. Suzuki, J. Watanabe, H. Hirayama, M. Sobue, G.

    Parkinsonism Relat Disord   Vol. 20 ( 5 ) page: 520-4   2014.5

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    DOI: 10.1016/j.parkreldis.2014.02.010

  69. 進化するParkinson病の治療 症状とその対応 新たなステージへ 自律神経症状とその対応 Reviewed

    渡辺, 宏久 中村, 友彦 平山, 正昭 祖父江, 元

    神経治療学   Vol. 31 ( 2 ) page: 175-179   2014.3

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  70. Recovery of flow-mediated vasodilatation after repetitive measurements is involved in early vascular impairment: comparison with indices of vascular tone Reviewed

      Vol. 9 ( 1 ) page: e83977   2014

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    In repetitive measurements of flow-mediated dilatation (FMD), the duration of the interval between measurements remains controversial. In this pilot study, we conducted three sequential measurements of low-flow-mediated constriction (L-FMC), FMD and flow-mediated total dilation (FMTD; L-FMC+ FMD) at baseline and intervals of 15 and 60 min in 30 healthy males. FMD15, L-FMC15, and FMTD15 were significantly lower than the respective first measurements, but all indices showed full recovery at 60 min in all subjects. The baseline diameter was slightly increased at 15 min and restored at 60 min, but the maximum diameter, and the baseline and reactive flow velocity unchanged. We examined the relationship between recovery rate of FMTD at 15 min (FMTD-R) and cardio-ankle vascular index (CAVI). Univariate analysis showed moderate correlation between FMTD-R, and CAVI and L-FMC0. Patients were divided according to FMTD-R value; the low-FMTD-R group [below the median value (-26.2%)] included a significantly higher proportion of smokers and higher CAVI values than the high-FMTD-R group. The reproducibility of FMTD and FMTD-R was evaluated in another group of 25 healthy subjects. The range of variation across measurements was 1.1% for FMTD and 4.6% for FMTD-R; with intraclass correlation coefficients of 0.93 and 0.95, respectively. The present study demonstrated blunted recovery of FMD within 15 min, suggesting the need for selection of a more adequate interval between measurements to avoid underestimation of FMD in subsequent measurements. The findings demonstrated the reproducibility of FMTD-R and FMTD measurements, and that FMTD-R might be involved in arterial stiffness and early vascular impairment in the healthy subjects.

    DOI: 10.1371/journal.pone.0083977

  71. Role of cardiac sympathetic nerves in preventing orthostatic hypotension in Parkinson's disease Reviewed

    Parkinsonism Relat Disord     2014

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    PURPOSE: Cardiac sympathetic denervation is associated with orthostatic hypotension (OH) in Parkinson's disease (PD); however, the physiological role of cardiac sympathetic nerves has yet to be elucidated. To clarify the role of the heart in orthostatic stress, we evaluated whether cardiac sympathetic nerves can alter cardiac activity and systolic blood pressure (BP) in association with elevations or depressions of total peripheral resistance during the head-up tilt test. METHODS: Ninety-five PD patients and 17 normal controls were enrolled. Using impedance cardiography, we measured total peripheral resistance, stroke volume, heart rate, and systolic BP during the head-up tilt test. Cardiac denervation was defined as a heart-to-mediastinum ratio <1.7 for cardiac 123I-metaiodobenzylguanidine uptake on delayed images. RESULTS: At 60 degrees tilt, total peripheral resistance decreased from the initial value in 49 PD patients. Among these, 36 patients exhibited cardiac denervation with severe reductions in systolic BP but little change in stroke volume; among these patients 22 had OH. The remaining 13 patients without cardiac denervation exhibited significant increases in stroke volume and well-preserved systolic BP with no OH. On the other hand, 46 patients had elevations in total peripheral resistance and reduced stroke volume, but little change in systolic BP, regardless of the presence or absence of cardiac denervation. Only one of these patients experienced OH. CONCLUSION: Under orthostatic stress, cardiac sympathetic denervation with failure to increase total peripheral resistance leads to large reductions in systolic BP. However, patients without cardiac denervation exhibited a positive inotropic response against vasodilatation, which may prevent OH.

    DOI: 10.1016/j.parkreldis.2014.01.003

  72. Cortical and subcortical brain atrophy in Parkinson's disease with visual hallucination Reviewed

    Mov Disord   Vol. 28 ( 12 ) page: 1732-6   2013.10

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    BACKGROUND: The aim of this study was to investigate the cortical and subcortical brain structures in Parkinson's disease (PD) with visual hallucination (VH), and to elucidate the association between the proposed hypothesis of VH in PD and regional brain volume changes. METHODS: We used 3T magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) to investigate the brain structures of PD patients with VH (PD-VH; n = 13) and PD patients without VH (PD-C; n = 13). RESULTS: The PD-VH patients showed significant cortical atrophy compared to the PD-C patients in the bilateral dorsolateral prefrontal cortex, left rostral region of the prefrontal cortex, left ventral section of the cingulate cortex, bilateral primary visual cortex, and secondary visual cortex including the left inferior occipital gyrus, right lingual cortex, right supramarginal gyrus, and left fusiform gyrus. Significant subcortical atrophic changes were observed in the white matter of the right parahippocampal gyrus, the bilateral posterior part of the cingulate gyrus, the left lingual gyrus, and the right middle occipital gyrus. CONCLUSIONS: VH in PD can occur due to distinctive neuroanatomical involvement.

    DOI: 10.1002/mds.25641

  73. 血圧と自律神経障害 神経疾患の起立性低血圧

    中村 友彦, 平山 正昭, 祖父江 元

    自律神経   Vol. 50 ( 3 ) page: 179-182   2013.9

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  74. 【足の特異な症候】 Parkinson病における下肢不随意運動 Reviewed

    渡辺 宏久, 伊藤 瑞規, 坪井 崇, 中村 友彦, 平山 正昭, 祖父江 元

    脊椎脊髄ジャーナル   Vol. 26 ( 7 ) page: 747-751   2013.7

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  75. パーキンソン病診療Q&A パーキンソン病の痩せ

    平山 正昭

    Frontiers in Parkinson Disease   Vol. 6 ( 2 ) page: 112-114   2013.5

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  76. Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3 Reviewed

    Suga, N. Katsuno, M. Koike, H. Banno, H. Suzuki, K. Hashizume, A. Mano, T. Iijima, M. Kawagashira, Y. Hirayama, M. Nakamura, T. Watanabe, H. Tanaka, F. Sobue, G.

    Neuropathol Appl Neurobiol     2013.4

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    DOI: 10.1111/nan.12055

  77. 骨格筋型塩化物イオンチャネル遺伝子(CLCN1)の複合ヘテロ接合体変異で重症化したThomsen病 Reviewed

    佐々木 良元, 高橋 正紀, 穀内 洋介, 平山 正昭, 衣斐 達, 冨本 秀和, 望月 秀樹, 佐橋 功

    臨床神経学   Vol. 53 ( 4 ) page: 316-319   2013.4

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    端者は22歳女性である。幼少期より重症な筋強直・筋肥大を示し、Thomsen病と臨床診断されていた。発端者の母側はきわめて軽症なThomsen病の優性家系で、父側は非罹患家系であった。CLCN1遺伝子解析では、重症の発端者にc.1615A>Gとc.1679T>C、軽症の母にc.1679T>C、無症候の父にc.1615A>Gの既報の変異がみとめられた。母は症候性Thomsen病、父は無症候性保因者であり、両変異の複合ヘテロ接合体が発端者の重症化に関与したものと考えた。Thomsen病の変異は浸透性が低く、同一家系内でも多様な重症度を示すが、非罹患家系の親に存在する変異により筋症状が重症化することがある。(

  78. Pilot study of H2 therapy in Parkinson's disease: A randomized double-blind placebo-controlled trial Reviewed

    Yoritaka, A. Takanashi, M. Hirayama, M. Nakahara, T. Ohta, S. Hattori, N.

    Mov Disord   Vol. 28 ( 6 ) page: 836-9   2013.2

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    DOI: 10.1002/mds.25375

  79. simple analytical method involving the use of a monolithic silica disk-packed spin column and HPLC-ECD for determination of L-DOPA in plasma of patients with Parkinson's disease Reviewed

    Tsunoda M, Hirayama M, Ohno K, Tsuda T

    Analytical Methods   Vol. 5 ( 19 ) page: 5161-5164   2013

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    L-DOPA (L-3,4-dihydroxyphenylalanine) is commonly used in the treatment of Parkinson's disease. Monitoring the concentration of L-DOPA in human plasma will enable dose optimization, but is rarely performed because current quantification methods are tedious and time-consuming. In this study, a simple method for the determination of L-DOPA in the plasma of patients with Parkinson's disease was developed. A monolithic silica disk-packed spin column with a phenylboronate moiety, which forms stable anionic complexes with the cis-hydroxyl groups of L-DOPA, was used to extract L-DOPA from plasma with extraction recoveries exceeding 90%. The extracted L-DOPA was then separated on a reversed-phase column and detected electrochemically with a boron-doped diamond electrode. The method, which has a limit of detection of 10 fmol, was then successfully applied for the determination of L-DOPA in the plasma of healthy volunteers and patients with Parkinson's disease.

    DOI: 10.1039/C3ay40934a

  80. 瞳孔機能障害とその検査法 神経変性疾患を中心にして Invited

    平山正昭

    自律神経   Vol. 49 ( 3 ) page: 162-165   2012.9

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  81. 体性感覚誘発電位(SEP)の導出部位の検討 Reviewed

    金沙玲 吉子健一 大熊相子 堤ちあき 松本祐之 中村友彦 平山正昭 松下正

    らぼ: 社団法人愛知県臨床衛生検査技師会誌   Vol. 63 ( 2 ) page: 13-15   2012.8

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  82. Impaired pain processing in Parkinson's disease and its relative association with the sense of smell Reviewed

    Hara, T. Hirayama, M. Mizutani, Y. Hama, T. Hori, N. Nakamura, T. Kato, S. Watanabe, H. Sobue, G.

    Parkinsonism Relat Disord   Vol. 19 ( 1 ) page: 43-6   2012.7

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  83. 【神経眼科-最新の話題】 Parkinson病の瞳孔機能検査の診断的意義 Invited

    平山正昭

    あたらしい眼科   Vol. 29 ( 6 ) page: 731-735   2012.6

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  84. 【自律神経とその病気】 パーキンソン病の自律神経障害 Invited

    平山正昭

    Brain medical   Vol. 24 ( 2 ) page: 137-141   2012.6

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  85. Ito, M. Hirayama, M. Yamai, K. Goto, S. Ito, M. Ichihara, M. Ohno, K. Reviewed

    Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats

      Vol. 2 ( 1 ) page: 15   2012.5

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  86. Discrimination of spinal and bulbar muscular atrophy from amyotrophic lateral sclerosis using sensory nerve action potentials Reviewed

    Hama, T. Hirayama, M. Hara, T. Nakamura, T. Atsuta, N. Banno, H. Suzuki, K. Katsuno, M. Tanaka, F. Sobue, G.

    Muscle Nerve   Vol. 45 ( 2 ) page: 169-74   2012.1

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    INTRODUCTION: Spinal and bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS) are motor neuron diseases. Sensory impairment is sometimes observed, and electrophysiological involvement has been described in the sensory nerves of SBMA patients. We hypothesized that a sensory nerve conduction study (NCS) could be used to discriminate SBMA from ALS. METHODS: We compared the results from NCSs in a total of 120 SBMA cases confirmed by genetic analysis, 188 ALS cases, and 50 normal subjects. RESULTS: Sensory nerve action potential (SNAP) amplitudes of the SBMA group were significantly lower than in the ALS and control groups. In addition, receiver-operating characteristic curve analysis for SNAP amplitude showed that a cut-off value of 13.8 muV for median, 10.7 muV for ulnar, and 9.9 muV for sural nerve best discriminated SBMA from ALS. CONCLUSIONS: The specific decrease of SNAP amplitude in SBMA provides another useful tool for the differential diagnosis of motor neuron diseases.

    DOI: 10.1002/mus.22291

  87. Paraneoplastic encephalitis associated with myasthenia gravis and malignant thymoma Reviewed

    Miyazaki, Y. Hirayama, M. Watanabe, H. Usami, N. Yokoi, K. Watanabe, O. Sobue, G.

    J Clin Neurosci   Vol. 19 ( 2 ) page: 336-8   2012.1

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  88. さまざまな音楽療法のかたち 医療と音楽療法の連携 名古屋大学におけるパーキンソン病に対する音楽療法の試み

    平山正昭,鵜飼久美子

    音楽医療研究   Vol. 4 ( 1 ) page: 1-5   2011.12

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    パーキンソン病の治療は、l-dopaの出現により飛躍的に生命予後などの治療効果が改善した疾患である。現在では、l-dopa以外にもドパミンアゴニスト、MAO-B阻害剤、COMT阻害剤などの新たな薬物治療やDBSなどの脳外科的手術療法も行われるようになった。薬物療法は、現在まで対症療法として運動症状の改善が見れらるが、進行抑制作用はない。また、薬剤療法では運動症状は改善するが、非運動症状の改善に関しては十分とはいえない。これに対して、リハビリテーションには、機能改善だけでなく、神経回路のリモデリングなど病気の進行抑制にも効果があると考えられているが、リハビリとして確立しているものは、Lee-Silverman言語療法が明らかな効果のあるリハビリとして知られているだけである。

  89. Anti-MuSK autoantibodies block binding of collagen Q to MuSK Reviewed

    Kawakami, Y. Ito, M. Hirayama, M. Sahashi, K. Ohkawara, B. Masuda, A. Nishida, H. Mabuchi, N. Engel, A. G. Ohno, K.

    Neurology   Vol. 77 ( 20 ) page: 1819-26   2011.10

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    OBJECTIVE: Muscle-specific receptor tyrosine kinase (MuSK) antibody-positive myasthenia gravis (MG) accounts for 5%-15% of autoimmune MG. MuSK mediates the agrin-signaling pathway and also anchors the collagenic tail subunit (ColQ) of acetylcholinesterase (AChE). The exact molecular target of MuSK-immunoglobulin G (IgG), however, remains elusive. As acetylcholine receptor (AChR) deficiency is typically mild and as cholinesterase inhibitors are generally ineffective, we asked if MuSK-IgG interferes with binding of ColQ to MuSK. METHODS: We used 3 assays: in vitro overlay of the human ColQ-tailed AChE to muscle sections of Colq-/- mice; in vitro plate-binding assay to quantitate binding of MuSK to ColQ and to LRP4; and passive transfer of MuSK-IgG to mice. RESULTS: The in vitro overlay assay revealed that MuSK-IgG blocks binding of ColQ to the neuromuscular junction. The in vitro plate-binding assay showed that MuSK-IgG exerts a dose-dependent block of MuSK binding to ColQ by but not to LRP4. Passive transfer of MuSK-IgG to mice reduced the size and density of ColQ to approximately 10% of controls and had a lesser effect on the size and density of AChR and MuSK. CONCLUSIONS: As lack of ColQ compromises agrin-mediated AChR clustering in Colq-/- mice, a similar mechanism may lead to AChR deficiency in MuSK-MG patients. Our experiments also predict partial AChE deficiency in MuSK-MG patients, but AChE is not reduced in biopsied NMJs. In humans, binding of ColQ to MuSK may be dispensable for clustering ColQ, but is required for facilitating AChR clustering. Further studies will be required to elucidate the basis of this paradox.

    DOI: 10.1212/WNL.0b013e318237f660

  90. Widespread cortical and subcortical brain atrophy in Parkinson's disease with excessive daytime sleepiness Reviewed

    Kato, S. Watanabe, H. Senda, J. Hirayama, M. Ito, M. Atsuta, N. Kaga, T. Katsuno, M. Naganawa, S. Sobue, G.

    J Neurol     2011.8

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    Our aim was to determine regional brain atrophy in Parkinson's disease (PD) patients with excessive daytime sleepiness (EDS) using voxel-based morphometry (VBM). From 71 consecutive probable PD patients, nine non-demented and non-hallucinating patients with an Epworth Sleepiness Scale (ESS) >/= 10 and 13 PD patients with an ESS </= 3 were selected as having EDS and as not having EDS, respectively. We also enrolled 22 healthy age- and sex-matched controls. Regional brain atrophy was assessed using VBM with 3-T magnetic resonance imaging. There was no difference in the dosage of dopaminergic drugs between PD patients with EDS and PD patients without EDS. PD patients with EDS showed marked atrophy in the gray matter of the frontal lobe, temporal lobe, occipital lobe, limbic lobe including the nucleus basalis of Meynert compared to controls (false discovery rate corrected p < 0.05). In contrast, PD patients without EDS did not show any significant difference in gray matter atrophy compared to controls (false discovery rate corrected p < 0.05). PD patients with EDS showed significant atrophy of the frontal lobe, temporal lobe, occipital lobe, limbic lobe including the nucleus basalis of Meynert compared to PD patients without EDS (uncorrected p < 0.001). PD patients with EDS, even without dementia and hallucination, showed significant gray matter atrophy compared to PD patients without EDS and controls.

    DOI: 10.1007/s00415-011-6187-6

  91. Tremor is attenuated during walking in essential tremor with resting tremor but not parkinsonian tremor Reviewed

    Uchida, K. Hirayama, M. Yamashita, F. Hori, N. Nakamura, T. Sobue, G.

    J Clin Neurosci   Vol. 18 ( 9 ) page: 1224-8   2011.7

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  92. パーキンソン病診断のコツとPitfall パーキンソン病とパーキンソニズムをきたす疾患の鑑別のポイント 首下がりの2症例 Invited

    平山正昭、久米明人

    Frontiers in Parkinson Disease   Vol. 4 ( 3 ) page: 142-145   2011.7

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  93. Does cardiovascular autonomic dysfunction contribute to fatigue in Parkinson's disease? Reviewed

    Nakamura, T. Hirayama, M. Hara, T. Hama, T. Watanabe, H. Sobue, G.

    mov disord     2011.5

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    Patients with Parkinson's disease often complain of fatigue, and although cardiac sympathetic denervation is thought to be associated with fatigue, this link remains unclear. Previously, we detected cardiac sympathetic denervation in patients with Parkinson's disease using dobutamine, a selective beta-1 stimulant. To clarify the involvement of autonomic dysfunction in fatigue in Parkinson's disease, we conducted autonomic function tests on 33 patients with Parkinson's disease (mean age, 66.1 +/- 5.6 years; 20 men, 13 women) and evaluated their relationships to fatigue. We divided patients into 2 groups, fatigued (n = 12) and nonfatigued (n = 21), based on an average score >/= 3.3 on the Parkinson fatigue scale. Autonomic function tests included the coefficient of variation of R-R intervals, head-up tilt test, norepinephrine and dobutamine infusion tests, and cardiac (123) I-metaiodobenzylguanidine scintigraphy. The coefficient of variation of R-R intervals and the systolic blood pressure changes accompanying the head-up tilt test did not show significant differences between the 2 groups; however, the pressor responses in the norepinephrine and dobutamine infusion tests were significantly greater in the fatigued group than in the nonfatigued group. The (123) I-metaiodobenzylguanidine heart-to-mediastinal uptake ratio was lower in the fatigued group than in the nonfatigued group. Partial correlation analyses, using disease duration and Hoehn and Yahr stage as control variables, also demonstrated significant correlations between the Parkinson fatigue scale score and the results of the autonomic function tests and cardiac (123) I-metaiodobenzylguanidine uptake. Our results suggest that autonomic dysfunction, including cardiac sympathetic denervation, is associated with fatigue in patients with Parkinson's disease. (c) 2011 Movement Disorder Society.

    DOI: 10.1002/mds.23744

  94. 【Parkinson病の新しい問題点】 Parkinson病の睡眠異常 Invited Reviewed

    平山正昭

    神経内科   Vol. 74 ( 1 ) page: 32-35   2011.1

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  95. 【Parkinson病の新しい問題点】 Parkinson病の反復常同行動(punding) Invited

    渡辺宏久, 伊藤瑞規, 川合圭成, 平山正昭, 祖父江元

    神経内科   Vol. 74 ( 1 ) page: 36-40   2011.1

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  96. The profile of motor unit number estimation (MUNE) in spinal and bulbar muscular atrophy. Reviewed

    SUZUKI Kisuke, KATSUNO Masahisa, BANNO Haruhiko, TAKEUCHI Yuko, KAWASHIMA M, SUGA Noriaki, HASHIZUME Akira, HAMA Tetsuo, UCHIDA Kei, YAMASHITA Fumitaka, NAKAMURA Tomohiko, HIRAYAMA Masaaki, TANAKA Fumiaki, SOBUE Gen.

    J Neurol Neurosurg Psychiatry.   Vol. 81 ( 5 ) page: 567-71   2010.12

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    DOI: 10.1136/jnnp.2009.190462

  97. Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease Reviewed

    Parkinsonism Relat Disord   Vol. 17 ( 1 ) page: 46-9   2010.11

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    DOI: 10.1016/j.parkreldis.2010.11.004

  98. 【見逃されやすい低血圧症 日常診療において注意するべきポイントを、わかりやすく解説!】 低血圧を伴う病態 食事性低血圧 Invited

    平山正昭

    治療   Vol. 92 ( 11 ) page: 2530-2534   2010.11

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  99. Putaminal magnetic resonance imaging features at various magnetic field strengths in multiple system atrophy. Reviewed

    WATANABE Hirohisa, ITO Mizuki, FUKATSU Hiroshi, SENDA Yuzuru, ATSUTA Naoki, KAGA Tomotsugu, KATO Shigenori, KATSUNO Masahisa, TANAKA Fumiaki, HIRAYAMA Masaaki, NAGAYAMA S, SOBUE Gen.

    Mov Disord   Vol. 25 ( 12 ) page: 1916-23   2010.9

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    DOI: 10.1002/mds.23196

  100. Lowered cardiac sympathetic nerve performance in response to exercise in Parkinson's disease. Reviewed

    NAKAMURA Tomohiko, HIRAYAMA Masaaki, YAMASHITA Fumiaki, UCHIDA Kei, HAMA Tetsuo, WATANABE Hirohisa, SOBUE Gen.

    Mov Disord   Vol. 25 ( 9 ) page: 1183-9   2010.7

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    DOI: 10.1002/mds.23127

  101. Pyramidal tract involvement in Guillain-Barre syndrome associated with anti-GM1 antibody Reviewed

    TOMITA Minoru, WATANABE Hirohisa, MOROZUMI S, KAWAGASHIRA Yuuichi, IIJAMA Masahiro, NAKAMURA Tomohiko, KATSUNO Masahisa, KOIKE Haruki, HATTORI Naoki, HIRAYAMA Masaaki, Kusunori S, SOBUE Gen.

    J Neurol Neurosurg Psychiatry   Vol. 81 ( 5 ) page: 583-5   2010.5

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    DOI: 10.1136/jnnp.2009.184945

  102. パーキンソン病の自律神経障害 Invited

    平山正昭

    MDSJ Letters   Vol. 3 ( 1 ) page: 8-10   2010.3

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  103. Pupillary autonomic dysfunction in multiple system atrophy and Parkinson's disease: an assessment by eye-drop tests. Reviewed

    YAMASHITA Fumiaki, HIRAYAMA Masaaki, NAKAMURA Tomohiko, TAKAMORI M, HORI N, UCHIDA Kei, HAMA Tetsuo, SOBUE Gen.

    Clin Auton Res.   Vol. 20 ( 3 ) page: 191-7   2010.2

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    DOI: 10.1007/s10286-009-0051-0

  104. *Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease Reviewed

    Fu, Y.Ito, M.Fujita, Y.Ichihara, M.Masuda, A.Suzuki, Y.Maesawa, S.Kajita, Y.Hirayama, M.Ohsawa, I.Ohta, S.Ohno, K.

    Neurosci Lett   Vol. 453 ( 2 ) page: 81-5   2009

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    Molecular hydrogen serves as an antioxidant that reduces hydroxyl radicals, but not the other reactive oxygen and nitrogen species. In the past year, molecular hydrogen has been reported to prevent or ameliorate eight diseases in rodents and one in human associated with oxidative stress. In Parkinson's disease, mitochondrial dysfunction and the associated oxidative stress are major causes of dopaminergic cell loss in the substantia nigra. We examined effects of approximately 50%-saturated molecular hydrogen in drinking water before or after the stereotactic surgery on 6-hydroxydopamine-induced nigrostrital degeneration in a rat model of Parkinson's disease. Methamphetamine-induced behavioral analysis showed that molecular hydrogen prevented both the development and progression of the nigrostrital degeneration. Tyrosine hydroxylase staining of the substantia nigra and striatum also demonstrated that pre- and post-treatment with hydrogen prevented the dopaminergic cell loss. Our studies suggest that hydrogen water is likely able to retard the development and progression of Parkinson's disease.

  105. The significance of carpal tunnel syndrome in transthyretin Val30Met familial amyloid polyneuropathy. Reviewed

    Koike H, Morozumi S, Kawagashira Y, Iijima M, Yamamoto M, Hattori N, Tanaka F, Nakamura T, Hirayama M, Ando Y, Ikeda S, Sobue G.

    Amyloid   Vol. 16 ( 3 ) page: 142-8   2009

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  106. *B-type natriuretic peptide and cardiovalvulopathy in Parkinson disease with dopamine agonist Reviewed

    Watanabe, H.Hirayama, M.Noda, A.Ito, M.Atsuta, N.Senda, J.Kaga, T.Yamada, A.Katsuno, M.Niwa, T.Tanaka, F.Sobue, G.

    neurology   Vol. 72 ( 7 ) page: 621-6   2009

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    OBJECTIVE: To elucidate the usefulness of plasma B-type natriuretic peptide (BNP) values for evaluating adverse effects of pergolide or cabergoline on cardiovalvulopathy in patients with Parkinson disease. METHODS: Twenty-five patients treated with pergolide or cabergoline (ergot group) and 25 patients never treated with ergot derivatives (non-ergot group) were enrolled. Plasma BNP values and detailed echocardiography were evaluated. Thirty age- and gender-matched controls were similarly evaluated. RESULTS: Patients with regurgitation more than grade 3 were more frequent in the ergot group than in the non-ergot group as well as control groups (24%, 0%, 3%, p = 0.001). Both composite regurgitation scores and plasma BNP values were significantly higher in the ergot group than in controls. In the ergot group, the cumulative dose correlated to both tenting area (r = 0.57, p = 0.004) and tenting distance (r = 0.62, p = 0.001). Furthermore, plasma BNP values were higher in patients with severe or multiple regurgitation groups (p < 0.001), and were correlated with composite regurgitation score (r = 0.70, p < 0.001). Multiple regression analyses revealed that BNP values were independently correlated with both composite regurgitation and left ventricular ejection fraction. CONCLUSION: The combination of comprehensive echocardiography and plasma B-type natriuretic peptide levels elucidates the presence of cardiac damage in patients with Parkinson disease using ergot derivative dopamine agonists.

  107. Electrophysiological features of late-onset transthyretin Met30 familial amyloid polyneuropathy unrelated to endemic foci Reviewed

    Koike, H.Kawagashira, Y.Iijima, M.Yamamoto, M.Hattori, N.Tanaka, F.Hirayama, M.Ando, Y.Ikeda, S.Sobue, G.

    J Neurol   Vol. 255 ( 10 ) page: 1526-33   2008.2

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    BACKGROUND : Through the development of gene diagnostic techniques, late-onset transthyretin Met30-associated familial amyloid polyneuropathy (FAP TTR Met30) has been shown to be more prevalent than is generally believed. OBJECTIVE : To examine the electrophysiological features of late-onset FAP TTR Met30 unrelated to endemic foci. METHODS : Nerve conduction findings in 44 cases with an onset of more than 50 years of age in a non-endemic area were assessed and compared with findings from 21 earlier-onset cases related to endemic foci. RESULTS : The extent of the reduction of the compound muscle action potential and, especially, the sensory nerve action potential was more profound in the late-onset group even when the decline of these indices with aging in normal control subjects was taken into account. The feature of predominant lower-limb involvement seemed to be more conspicuous in the late-onset group. Electrophysiological indices tended to be aggravated as the duration of neuropathic symptoms increased in the early-onset group, while most of these indices in the lateonset group did not show this correlation. A slowing of conduction velocity and a prolongation of distal latency, which suggests demyelination, were conspicuous in some patients. Pathologically, a predominant loss of small-fibers was not conspicuous in sural nerve biopsy specimens from late-onset patients. Large myelinated fiber density showed a negative correlation with the disease duration in early-onset cases, but not in late-onset cases. CONCLUSIONS : Electrophysiological differences between late- and early-onset cases were present, probably reflecting the different underlying pathogenic mechanisms of neuropathy. The demyelinating feature does not exclude the possibility of this disease.

  108. *The video images of sleep attacks in Parkinson's disease Reviewed

    Hirayama, M.Nakamura, T.Hori, N.Koike, Y.Sobue, G.

    movement disorder   Vol. 23 ( 2 )   2008

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    We describe a sleep attack, which was induced by taking excessive levodopa and pergolide, in a 73-year-old woman with Parkinson's disease. At the onset of the sleep attack, her head suddenly sagged and sometimes hit the table, but she did not notice these symptoms. Her family noticed that this sleep attack occurred when she began to speak slowly. Her family recorded this attack with a video camera. This sleep attack resolved with control of her medication. This is the first report of video images of a sleep attack due to excessive levodopa and a dopamine agonist.

  109. *CAG repeat size correlates to electrophysiological motor and sensory phenotypes in SBMA

    Suzuki, K.Katsuno, M.Banno, H.Takeuchi, Y.Atsuta, N.Ito, M.Watanabe, H.Yamashita, F.Hori, N.Nakamura, T.Hirayama, M.Tanaka, F.Sobue, G.

    brain   Vol. 131 ( Pt1 ) page: 229-39   2008

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    Spinal and bulbar muscular atrophy (SBMA) is an adult-onset, lower motor neuron disease caused by an aberrant elongation of a CAG repeat in the androgen receptor (AR) gene. The main symptoms are weakness and atrophy of bulbar, facial and limb muscles, but sensory disturbances are frequently found in SBMA patients. Motor symptoms have been attributed to the accumulation of mutant AR in the nucleus of lower motor neurons, which is more profound in patients with a longer CAG repeat. We examined nerve conduction properties including F-waves in a total of 106 patients with genetically confirmed SBMA (mean age at data collection = 53.8 years; range = 31-75 years) and 85 control subjects. Motor conduction velocities (MCV), compound muscle action potentials (CMAP), sensory conduction velocities (SCV) and sensory nerve action potentials (SNAP) were significantly decreased in all nerves examined in the SBMA patients compared with that in the normal controls, indicating that axonal degeneration is the primary process in both motor and sensory nerves. More profound abnormalities were observed in the nerves of the upper limbs than in those of the lower limbs. F-waves in the median nerve were absent in 30 of 106 cases (28.3%), but no cases of absent F-waves were observed in the tibial nerve. From an analysis of the relationship between CMAPs and SNAPs, patients were identified with different electrophysiological phenotypes: motor-dominant, sensory-dominant and non-dominant phenotypes. The CAG repeat size and the age at onset were significantly different among the patients with motor- and sensory-dominant phenotypes, indicating that a longer CAG repeat is more closely linked to the motor-dominant phenotype and a shorter CAG repeat is more closely linked to the sensory-dominant phenotype. Furthermore, when we classified the patients by CAG repeat size, CMAP values showed a tendency to be decreased in patients with a longer CAG repeat (> or =47), while SNAPs were significantly decre

  110. MM2-cortical-type sporadic Creutzfeldt-Jakob disease with early stage cerebral cortical pathology presenting with a rapidly progressive clinical course Reviewed

    Niimi, Y.Iwasaki, Y.Umemura, T.Tanaka, F.Yoshida, M.Hashizume, Y.Kitamoto, T.Hirayama, M.Sobue, G.

    Neuropathology   Vol. 28 ( 6 ) page: 645-51   2008

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    We report the case of a 67-year-old man with MM2-cortical-type sporadic Creutzfeldt-Jakob disease (sCJD) with a rapidly progressive clinical course of 5 months. Initial symptoms were progressive memory disturbance and dementia. MRI revealed high signal-intensity lesions on diffusion-weighted images in the bilateral frontal and occipital cortices. Myoclonus and periodic sharp-wave complexes on the electroencephalogram were observed in the early disease stage. The clinical diagnosis was typical sCJD. Neuropathologic examination at autopsy showed widespread, characteristic cerebral neocortical involvement with large confluent vacuole-type spongiform change. Spongiform degeneration was also evident in the striatum and medial thalamus. In the cerebellar cortex, slight depletion of Purkinje neurons was evident without spongiform change in the molecular layer or apparent neuron loss in the granule cell layer. The inferior olivary nucleus showed slight hypertrophic astrocytosis without neuron loss. Prion protein (PrP) immunostaining showed widespread, characteristic perivacuolar-type PrP deposits with irregular plaque-like PrP deposits in the cerebral neocortex, striatum and medial thalamus. We believe this patient showed early-stage cerebral cortical pathology of MM2-cortical-type sCJD, which may provide clues regarding the pathologic progression of this rare sCJD subtype. Although MM2-cortical-type sCJD generally shows slow progression without myoclonus or periodic sharp-wave complexes, the present patient showed a rapidly progressive clinical course similar to that of MM1-type sCJD.

  111. Pupillary supersensitivity and visual disturbance in Parkinson's disease

    Hori, N.Takamori, M.Hirayama, M.Watanabe, H.Nakamura, T.Yamashita, F.Ito, H.Mabuchi, N.Sobue, G.

    Clin Auton Res   Vol. 18 ( 1 ) page: 20-7   2008

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    This study evaluated pupillary postganglionic autonomic dysfunction and its relationship to visual disturbance in idiopathic Parkinson's disease (PD). Pupillary sensitivity was examined in relation to a parasympathomimetic agent [0.05% pilocarpine hydrochloride (PL)] and to a sympathomimetic agent [0.02% dipivefrine hydrochloride (DPE)] using infrared pupillography in 40 PD patients and 17 age-matched controls. Visual disturbances were evaluated as well, including blurring, photophobia, night blindness and involuntary eyelid closure in response to light. Pupillary supersensitivity to PL and DPE and their relation to visual disturbances were found to be significantly greater in PD patients than in controls (22.3 +/- 15.1 vs. 10.4 +/- 11.4%, P < 0.005, and14.5 +/- 14.5 vs. 4.9 +/- 8.7%, P < 0.01, respectively). In addition, pupillary sympathetic supersensitivity did not correlate with a reduction of 123I-metaiodobenzylguanidine (MIBG) cardiac accumulation. Patients with PD reported more blurred vision (P < 0.001) and involuntary eyelid closure in response to light (P < 0.05) than controls. Patients with supersensitivity to both PL and DPE complained more often of blurred vision than patients without supersensitivity (P < 0.05). Pupillary sensitivity to PL correlated significantly with a summed score for visual disturbance (P < 0.05, r = 0.417), but DPE sensitivity did not. PD patients have both parasympathetic and sympathetic postganglionic impairments affecting the pupil. Our findings demonstrate that parasympathetic dysfunction contributes significantly to visual disturbance in PD.

  112. Ataxic vs painful form of paraneoplastic neuropathy. Reviewed

    Oki Y, Koike H, Iijima M, Mori K, Hattori N, Katsuno M, Nakamura T, Hirayama M, Tanaka F, Shiraishi M, Yazaki S, Nokura K, Yamamoto H, Sobue G.

    Neurology   Vol. 69 ( 6 ) page: 564-72   2007.8

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  113. *Dobutamine stress test unmasks cardiac sympathetic denervation in Parkinson's disease. Reviewed

    Nakamura T, Hirayama M, Ito H, Takamori M, Hamada K, Takeuchi S, Watanabe H, Koike Y, Sobue G.

    J Neurol Sci   Vol. 263 ( 1-2 ) page: 133-8   2007.7

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    OBJECTIVE: Cardiac uptake of [(123)I]metaiodobenzyl guanidine (MIBG) is reduced in patients with Parkinson's disease (PD). However, the cardiac sympathetic abnormality associated with this reduction is unclear. To unmask this abnormality in PD patients we examined the functional consequences of cardiac beta-receptor activation. METHODS: Cardiovascular responses to stepwise administration of the beta1-receptor agonist, dobutamine (DOB), were assessed in 25 PD patients and 12 age-matched controls. Changes in blood pressure were compared to determine the optimal dose at which to detect denervation supersensitivity, and cardiac contractility was measured by DOB echocardiography, based on peak aortic flow velocity. The relations of these cardiovascular responses to the ratio of MIBG uptake into the heart vs. that into the mediastinum (H/M ratio) were analyzed. RESULTS: At 4 microg/kg/min DOB, systolic blood pressure increased more in PD patients than in controls (PD, 17.5+/-12.3 mm Hg; control, 7.2+/-6.2 mm Hg, p<0.01), suggesting the presence of denervation supersensitivity. At this DOB dose cardiac contractility also increased more in PD than in controls (PD, 39.0+/-15.7%; control, 23.5+/-5.2%, p<0.005) and this hyperdynamic response was significantly correlated with reduced H/M ratios (early: r=-0.63, p<0.01, delayed: r=-0.66, p<0.01). CONCLUSION: Low-dose DOB unmasks cardiac sympathetic denervation in PD patients, and decreased MIBG uptake indicates the presence of denervation supersensitivity within the heart, resulting in hyperdynamic cardiac contractility in response to a beta 1-stress condition.

  114. Altered venous capacitance as a cause of postprandial hypotension in multiple system atrophy. Reviewed

    Takamori M, Hirayama M, Kobayashi R, Ito H, Mabuchi N, Nakamura T, Hori N, Koike Y, Sobue G.

    Clin Auton Res   Vol. 17 ( 1 ) page: 20-25   2007.2

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  115. Sweating dysfunctions in Parkinson's disease. Reviewed

    Hirayama M.

    J Neurol   Vol. 253 ( suppl 7 ) page: vii42-47   2006.12

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  116. パーキンソン病におけるドブタミン負荷試験の有用性 MIBG心筋シンチとの関連(第2報) Reviewed

    中村友彦, 平山正昭, 伊藤宏樹, 高森元子, 堀紀生, 祖父江元

    自律神経   Vol. 43 ( 5 ) page: 431-435   2006.10

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  117. 【しびれの臨床】 自律神経障害 Reviewed

    中村友彦(名古屋大学 大学院医学系研究科神経内科学), 平山正昭, 祖父江元

    総合臨床   Vol. 55 ( 9 ) page: 2201-2206   2006.9

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  118. パーキンソン病におけるドブタミン負荷試験の有用性 MIBG心筋シンチとの関連を中心に Reviewed

    中村友彦, 平山正昭, 伊藤宏樹, 高森元子, 馬渕直紀, 浜田健介, 竹内茂雄, 祖父江元

    自律神経   Vol. 42 ( 2 ) page: 295-300   2005.12

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  119. 球脊髄性筋萎縮症における末梢神経伝導の特徴 Reviewed

    鈴木啓介, 勝野雅央, 坂野晴彦, 熱田直樹, 渡辺宏久, 伊藤宏樹, 平山正昭, 祖父江元

    末梢神経   Vol. 16 ( 2173-175 )   2005.12

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  120. Neuronal intranuclear hyaline inclusion disease showing motor-sensory and autonomic neuropathy. Reviewed

    Sone J, Hishikawa N, Koike H, Hattori N, Hirayama M, Nagamatsu M, Yamamoto M, Tanaka F, Yoshida M, Hashizume Y, Imamura H, Yamada E, Sobue G.

    Neurology   Vol. 65 ( 10 ) page: 1538-43   2005.11

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  121. CADASIL with NOTCH3 S180C presenting anticipation of onset age and hallucinations. Reviewed

    Nakamura T, Watanabe H, Hirayama M, Inukai A, Kabasawa H, Matsubara M, Mitake S, Nakamura M, Ando Y, Uchino M, Sobue G.

    J Neurol Sci   Vol. 238 ( 1-2 ) page: 87-91   2005.11

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  122. 脳波・筋電図の臨床 自律神経不全症患者の起立性低血圧時脳血流自動調節能 近赤外線分光法による検討 Reviewed

    伊藤宏樹, 平山正昭, 古池保雄, 祖父江元

    臨床脳波   Vol. 47 ( 10 ) page: 629-632   2005.10

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  123. Age associated axonal features in HNPP with 17p11.2 deletion in Japan. Reviewed

    Koike H, Hirayama M, Yamamoto M, Ito H, Hattori N, Umehara F, Arimura K, Ikeda S, Ando Y, Nakazato M, Kaji R, Hayasaka K, Nakagawa M, Sakoda S, Matsumura K, Onodera O, Baba M, Yasuda H, Saito T, Kira J, Nakashima K, Oka N, Sobue G.

    J Neurol Neurosurg Psychiatry.   Vol. 76 ( 8 ) page: 1109-14   2005.8

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  124. Progression and prognosis in pure autonomic failure (PAF): comparison with multiple system atrophy. Reviewed

    Mabuchi N, Hirayama M, Koike Y, Watanabe H, Ito H, Kobayashi R, Hamada K, Sobue G.

    J Neurol Neurosurg Psychiatry.   Vol. 76 ( 7 ) page: 947-952   2005.7

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  125. The wide spectrum of clinical manifestations in Sjogren's syndrome-associated neuropathy. Reviewed

    Mori K, Iijima M, Koike H, Hattori N, Tanaka F, Watanabe H, Katsuno M, Fujita A, Aiba I, Ogata A, Saito T, Asakura K, Yoshida M, Hirayama M, Sobue G

    Brain   Vol. 128   page: 2518-34   2005.7

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  126. パーキンソン病の妄想に対するolanzapineの有用性 Reviewed

    伊藤瑞規, 熱田直樹, 渡邉宏久, 平山正昭, 祖父江元

    脳と神経   Vol. 57 ( 6 ) page: 491-494   2005.6

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  127. Clinical and electrophysiologic correlates of IVIg responsiveness in CIDP. Reviewed

    Iijima M, Yamamoto M, Hirayama M, Tanaka F, Katsuno M, Mori K, Koike H, Hattori N, Arimura K, Nakagawa M, Yoshikawa H, Hayasaka K, Onodera O, Baba M, Yasuda H, Saito T, Nakazato M, Nakashima K, Kira J, Kaji R, Oka N, Sobue G.

    Neurology   Vol. 64 ( 8 ) page: 1471-5   2005.4

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  128. Primary lateral sclerosis presenting parkinsonian symptoms without nigrostriatal involvement Reviewed

    Mabuchi N, Watanabe H, Atsuta N, Hirayama M, Ito H, Fukatsu H, Kato T, Ito K, Sobue G.

    J Neurol Neurosurg Psychiatry   Vol. 75 ( 12 ) page: 1768-1771   2004.12

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  129. The effects of levodopa on apraxia of lid opening: A case report. Reviewed

    Yamada S, Matsuo K, Hirayama M, Sobue G.

    Neurology.   Vol. 62 ( 5 ) page: 830-831   2004.3

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  130. Nerve excitability properties in Charcot-Marie-Tooth disease type 1A. Reviewed

    )Nodera H, Bostock H, Kuwabara S, Sakamoto T, Asanuma K, Jia-Ying S, Ogawara K, Hattori N, Hirayama M, Sobue G, Kaji R.

    Brain   Vol. 127 ( Pt 1 ) page: 203-211   2004.1

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  131. Multiple regional (1)H-MR spectroscopy in multiple system atrophy: NAA/Cr reduction in pontine base as a valuable diagnostic marker. Reviewed

    Watanabe H, Fukatsu H, Katsuno M, Sugiura M, Hamada K, Okada Y, Hirayama M, Ishigaki T, Sobue G.

    J Neurol Neurosurg Psychiatry   Vol. 75 ( 1 ) page: 103-109   2004.1

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  132. Postgastrectomy polyneuropathy with thiamine deficiency is identical to beriberi neuropathy Reviewed

    Koike H, Iijima M, Mori K, Hattori N, Ito H, Hirayama M, Sobue G.

    Nutrition   Vol. 20   page: 961-966   2004

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  133. Parkinson病の非運動症状とその治療 自律神経障害 Reviewed

    平山正昭

    神経治療学   Vol. 21 ( 6 ) page: 699-701   2004

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  134. 多系統萎縮症と自律神経障害 多系統萎縮症における睡眠時呼吸障害 Reviewed

    平山正昭, 古池保雄

    自律神経   Vol. 41 ( 2 ) page: 146-149   2004

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  135. Sjogren's syndrome associated painful sensory neuropathy without sensory ataxia. Reviewed

    Mori Keiko, Iijima Masahiro, Sugiura Makoto, Koike Haruki, Hattori Naoki, Ito Hiroki, Hirayama Masaaki, Sobue Gen.

    J Neurol Neurosurg Psychiatry   Vol. 74 ( 9 ) page: 1320-1322   2003.9

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  136. Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. Reviewed

    Koike Haruki, Iijima Masahiri, Sugiura Makoto, Mori Keiko, Hattori Naoki, Ito Hiroki, Hirayama Masaaki, Sobue Gen.

    Ann Neurol   Vol. 54 ( 1 ) page: 19-29   2003.7

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  137. Onset age and severity of motor impairment are associated with reduction of myocardial (123)I-MIBG uptake in Parkinson's disease Reviewed

    Hamada Kensuke, Hirayama Masaaki, Watanabe Hirohisa, Kobayashi Rei, Ito Hiroki, Ieda Toshiaki, Koike Yasuo, Sobue Gen.

    J Neurol Neurosurg Psychiatry   Vol. 74 ( 4 ) page: 423-426   2003.4

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  138. Skin sympathetic nerve function during sleep-a study with effector responses. Reviewed

    Kobayashi Rei, Koike Yasuo, Hirayama Masaaki, Ito Hiroki, Sobue Gen.

    Auton Neurosci   Vol. 103 ( 1-2 ) page: 121-126   2003.1

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  139. Sequential constriction of upper airway and vocal cords in sleep apnea of multiple system atrophy Reviewed

    Hirayama Masaaki, Fukatsu Hiroshi, Watanabe Hirohisa, Koike Yasuo,Noda Akiko , Ito Hiroki, Kobayashi Rei, Sobue Gen,

    J Neurol Neurosurg Psychiatry   Vol. 74   page: 642-645   2003

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  140. 呼吸と自律神経 Shy-Drager症候群における睡眠時呼吸障害(解説) Reviewed

    平山正昭、 古池保雄

    自律神経   Vol. 40 ( 3 ) page: 269-274   2003

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  141. Chronic inflammatory demyelinating polyneuropathy presenting with features of GBS. Reviewed

    Mori K, Hattori N, Sugiura M, Koike H, Misu K, Ichimura M, Hirayama M, Sobue G.

    Neurology   Vol. 58 ( 6 ) page: 972-982   2002.3

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  142. Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients. Reviewed

    Watanabe H, Saito Y, Terao S, Ando T, Kachi T, Mukai E, Aiba I, Abe Y, Tamakoshi A, Doyu M, Hirayama M, Sobue G.

    Brain   Vol. 125   page: 1070-1083   2002

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  143. Brainstem-type body disease presenting with progressive autonomic failure and lethargy. Reviewed

    Hishikawa N, Hashizume Y, Hirayama M, Imamura K, Washimi Y, Koike Y, Mabuchi C, Yoshida M, Sobue G

    Review Series DEMENTIA   Vol. 1   page: 20-24   2002

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  144. 低磁場MRIを用いた睡眠時無呼吸時の上気道と声帯の変化-多系統萎縮症と肥満による閉塞性無呼吸症との対比- Reviewed

    平山正昭、渡辺宏久、深津博、古池保雄、野田明子、伊藤宏樹、小林麗、祖父江元

    自律神経   Vol. 39   page: 383-384   2002

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  145. アムロジピンの血圧と総頸動脈血流速度とに及ぼす効果 Reviewed

    平山正昭, 家田俊明, 祖父江元

    医学と薬学   Vol. 47   page: 257-262   2002

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  146. Postgastrectomy polyneuropathy with thiamine deficiency. Reviewed

    Koike H, Misu K, Hattori N, Ito S, Ichimura M, Ito H, Hirayama M, Nagamatsu M, Sasaki I, Sobue G.

    J Neurol Neurosurg Psychiatry   Vol. 71 ( 3 ) page: 357-362   2001.9

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  147. Axillary nerve injury caused by intradeltoid muscular injection: A case report. Reviewed

    Choi HR, Kondo S, Mishima S, Shimizu T, Hasegawa Y, Ida K, Hirayama M, Iwata H.

    J Shoulder Elbow Surg   Vol. 10 ( 5 ) page: 493-495   2001.9

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  148. Cardiac (123)I-meta-iodobenzylguanidine (MIBG) uptake in dementia with Lewy bodies: comparison with Alzheimer's disease. Reviewed

    Watanabe H, Ieda T, Katayama T, Takeda A, Aiba I, Doyu M, Hirayama M, Sobue G.

    J Neurol Neurosurg Psychiatry   Vol. 70 ( 6 ) page: 781-783   2001.6

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  149. Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status. Reviewed

    Koike H, Mori K, Misu K, Hattori N, Ito H, Hirayama M, Sobue G.

    Neurology   Vol. 56 ( 12 ) page: 1727-1732   2001.6

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  150. Age of onset influences clinical features of chronic inflammatory demyelinating polyneuropathy. Reviewed

    Hattori N, Misu K, Koike H, Ichimura M, Nagamatsu M, Hirayama M, Sobue G.

    J Neurol Sci   Vol. 184 ( 1 ) page: 57-63   2001.2

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  151. FAPの自律神経障害について:特集FAP(家族性アミロイドポリニューロパチー)治療の進歩 Reviewed

    平山正昭,渡辺宏久,祖父江元

    神経内科   Vol. 55   page: 541-546   2001

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  152. An axonal form of Charcot-Marie-Tooth disease showing distinctive features in association with mutations in the peripheral myelin protein zero gene (Thr124Met or Asp75Val). Reviewed

    Misu K, Yoshihara T, Shikama Y, Awaki E, Yamamoto M, Hattori N, Hirayama M, Takegami T, Nakashima K, Sobue G.

    J Neurol Neurosurg Psychiatry   Vol. 69 ( 6 ) page: 806-811   2000.12

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  153. Clinical effects of elastic bandage on neurogenic orthostatic hypotension. Reviewed

    Hasegawa Y, Hakusui S, Hirayama M, Ieda T, Koike Y, Matsuoka Y, Takahashi A.

    J Gravit Physiol   Vol. 7 ( 2 ) page: 159-160   2000.7

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  154. Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy Reviewed

    Nozomi Hishikawa, Yoshio Hashizume, Masaaki Hirayama, Kazuhiro Imamura, Yukihiko Washimi, Yasuo Koike, Chiyuki Mabuchi Mari Yoshida, Gen Sobue

    Clin Autonom Res   Vol. 10   page: 139-143   2000

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  155. 慢性自律神経不全症における食事性低血圧発現の病態-食事性低血圧に対するβ1刺激薬とα1刺激薬1カ月間の併用療法- Reviewed

    平山正昭,家田俊明,古池保雄,高橋昭,祖父江元

    臨床神経   Vol. 40   page: 787-790   2000

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  156. 起立性低血圧時の血液循環動態ー組織Hb量モニターによる検討ー Reviewed

    平山正昭 伊藤宏樹 家田俊明 祖父江元 古池保雄

    自律神経   Vol. 37   page: 76-79   2000

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  157. Clinical and physiological characteristics of autonomic failure with Parkinson's disease. Reviewed

    Niimi Y, Ieda T, Hirayama M, Koike Y, Sobue G, Hasegawa Y, Takahashi A

    Clin Auton Res   Vol. 9 ( 3 ) page: 139-144   1999.6

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  158. Perieto-occipital glucose hypometabolism in Parkinson's disease with autonomic failure. Reviewed

    Yutaka Arahata, Masaaki Hirayama, Toshiaki Ieda, Yasuo Koike, Takashi Kato, Masanori Tadokoro, Mitsuru Ieda, Kengo Ito, Gen Sobue

    J Neurol Sciences   Vol. 163   page: 119-126   1999

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  159. Auditory brainstem responses in patients with autonomic failure with Parkinson's disease and multiple system atrophy Reviewed

    Yoshihisa Kodama, Toshiaki Ieda, Masaaki Hirayama, Yasuo Koike, Hiroki Ito, Gen Sobue

    J Auton Nerv Syst   Vol. 77   page: 184-189   1999

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  160. シャイ・ドレーガー症候群と自律神経障害 Reviewed

    平山正昭,祖父江元

    心身医療   Vol. 10   page: 47-50   1998

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  161. Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome Reviewed

    Yasuhiro Ito, Yutaka Arahata, Youji Goto, Masaaki Hirayama, Masaaki Nagamutsu, Takeshi Yasuda, Tsutomu Yanagi, Gen Sobue

    American Journal of Neuroradiology   Vol. 19   page: 415-417   1998

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  162. Parkinson病の食事性低血圧 Reviewed

    平山正昭,家田俊明,長谷川康弘

    神経内科   Vol. 48   page: 129-133   1998

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  163. 脊髄小脳変性症と弱視患者にみられた交代性眼振 Reviewed

    平山正昭,伊藤宏樹,川上治,祖父江元

    神経内科   Vol. 49   page: 168-169   1998

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  164. めまいの診断と治療 自律神経疾患とめまい Reviewed

    平山正昭,祖父江元

    診断と治療   Vol. 86   page: 1202-1207   1998

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  165. Relationship between respiratory failure and plasma noradrenaline levels in amyotrophic lateral sclerosis. Reviewed

    Akiko Yamashita, Yasuo Koike, Akira Takahashi, Masaaki Hirayama, Nobuo Murakami, Gen Sobue

    Clinical Autonom Res   Vol. 7   page: 173-177   1997

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  166. 123I-metaiodobenzylguanidineを用いた四肢末梢交感神経の評価 Reviewed

    平山正昭,加藤隆司

    神経内科   Vol. 47   page: 158-163   1997

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  167. 現代臨床機能検査ーその実際と解釈ー自律神経系機能検査.理学的検査法 Reviewed

    平山正昭,古池保雄

    日本臨牀   Vol. 55   page: 487-490   1997

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  168. 現代臨床機能検査ーその実際と解釈ー自律神経系機能検査.薬理学的検査法 Reviewed

    平山正昭,古池保雄

    日本臨牀   Vol. 55   page: 491-493   1997

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  169. Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model

    Ushida, T. Kotani, T. Tsuda, H. Imai, K. Nakano, T. Hirako, S. Ito, Y. Li, H. Mano, Y. Wang, J. Miki, R. Yamamoto, E. Iwase, A. Bando, Y. K. Hirayama, M. Ohno, K. Toyokuni, S. Kikkawa, F.

    Free Radic Biol Med   Vol. 101   page: 524-533   1996.10

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    DOI: 10.1016/j.freeradbiomed.2016.10.491

  170. Orthostatic hypotension caused by a localised dorsal medullary tumour. Reviewed

    Akiko Yamashita, Masaaki Hirayama , Yasuo Koike , Megumi Nukata , Makoto Hashizume and Akira Takahashi

    J Neuro Neurosurg Phychiatry   Vol. 61   page: 118-119   1996

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  171. 123I-metaiodobenzylguanidineを用いた四肢末梢交感神経の定量的評価 Reviewed

    平山正昭,古池保雄,家田俊明,白水重尚,祖父江 元,伊藤健吾,加藤隆司,長谷川康博,高橋 昭

    自律神経   Vol. 33   page: 409-413   1996

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  172. scintigraphical qualitative analysis of peripheral vascular sympathetic function with meta-[123I]-iodobenzylguanidine in neurological patients with autonomic failure. Reviewed

    Masaaki Hirayama,Shigetaka Hakusui,Yasuo Koike,Kengo Itoh,Mituru Ikeda,Takashi Katoh,Akira Takahashi

    J Auton Nerv Syst   Vol. 53   page: 230-234   1995

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  173. Gastrointestinal dysfunction in Pakinson's disease detected by Electrogastroenterography. Reviewed

    Yoshiki Kaneoke,Yasuo Koike,Nobuo Sakurai,Yukihiko Washimi,Masaaki Hirayama,Minoru Hoshiyama,Akira Takahashi

    J Auton Nerv Syst   Vol. 50   page: 275-281   1995

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  174. 進行性自律神経機能不全症における運動時低血圧 Reviewed

    平山正昭,家田俊明,新美由紀,古池保雄,高橋 昭

    自律神経   Vol. 32   page: 430-434   1995

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  175. 123I-metaiodobenzylguanidineを用いた四肢末梢交感神経の定性評価 Reviewed

    平山正昭,白水重尚,古池保雄,伊藤健吾,池田 充,長谷川康博,高橋 昭

    自律神経   Vol. 32   page: 127-131   1995

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  176. Hemodynamic assessment of postprandial hypotension in patients with autonomic failure. Reviewed

    Akira Takahashi,Yasuo Koike,Nobuo Sakurai,Yasuhiro Hasegawa,Masaaki Hirayama,Shigetaka Hakusui,Toshiaki Ieda

    Muscle & Nerve   Vol. 17 ( Suppl 1 ) page: S41   1994

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  177. Staircase phenomenonを指標としたミトコンドリア脳筋症に対するcoenzymeQ10の治療効果の評価 Reviewed

    平山正昭,古池保雄,本田 仁,高橋 昭

    神経治療   Vol. 11   page: 359-363   1994

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  178. A radiological analysis of heart sympathetic function with meta-[123I]iodobenzylguanidine in neurological patients with autonomic failure Reviewed

    Shigetaka Hakusui,Takashi Yasuda,Tsutomu Yanagi,Junichiro Tohyoma,Yasuhiro Hasegawa,Yasuo Koike,Masaaki Hirayama,Akira Takahashi

    J Auton Nerv Syst   Vol. 49   page: 81-84   1994

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  179. 自律神経機能不全における食事性低血圧発現の病態(6)-食事内容による消化管ペプチドの比較検討- Reviewed

    平山正昭,家田俊明,古池保雄,竹内有子,竹内茂雄,櫻井信夫,長谷川康博,高橋 昭

    自律神経   Vol. 311994   page: 47-51   1994

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  180. 自律神経機能不全症における食事性低血圧発現の病態(7)-Pure autonomic failureと多系統萎縮症患者との脳循環自動能の差異- Reviewed

    平山正昭,古池保雄,久米明人,家田俊明,加藤隆司,伊藤健吾,池田 充,高橋 昭

    自律神経   Vol. 31   page: 455-461   1994

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  181. 食事性低血圧 Reviewed

    平山正昭

    神経内科   Vol. 40   page: 516-526   1994

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  182. Abnormalities in the oligosaccaride moieties of immunoglobulin G in patients with myotonic dystrophy. Reviewed

    Keita Itoh, Noriko Takahashi, Masaaki Hirayama, Hitoshi Honda, Akira Takahashi

    J. Clin. Biochem. Nutri.   Vol. 14   page: 61-69   1993

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  183. 自律神経機能不全症における食事性低血圧発現の病態(4)-食事性低血圧における脳血流 Reviewed

    平山正昭,久米明人,加藤隆司,古池保雄,竹内有子,竹内茂雄,高橋 昭

    自律神経   Vol. 30   page: 530-534   1993

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  184. Treatment of postprandal hypotension with selective α1 and β1 adrenergic agonist Reviewed

    Masaaki Hirayama,Hidetsugu Watanabe,Yasuo Koike,Yoshiki Kaneoka,Nobuo Sakurai,Sigetaka Hakusui,Akira Takahashi

    J. Autonom Nerv sys   Vol. 45   page: 149-154   1993

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  185. Postprandial hypotension:hemodynamic differences between MSA and periperal automomic neuropathy Reviewed

    Masaaki Hirayama,Hidetsugu Watanabe,Yasuo Koike,Yasuhiro Hasegawa,Yoshiki Kaneoke,Nobuo Sakurai,Sigetaka Hakusui,Akira Takahashi

    J. Autonom Nerv sys   Vol. 43   page: 1-6   1993

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  186. 進行性自律神経不全症例の食事性低血圧に対するβ1刺激薬とα1刺激薬の併用効果 Reviewed

    平山正昭,古池保雄,渡辺英嗣,金桶吉起,高橋 昭

    臨床神経   Vol. 32   page: 1208-1212   1992

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  187. Administration of vasopressin preparation therapy for postprandial hypotension asnasal drops Reviewed

    Sigetaka Hakusui,Akira Takahashi,Tadaaki Mano,Yasuhiro Hasegawa,Yasuo Koike,Yoshiki Sugiyama,Satosi Iwase,Masaaki Hirayama,Takeshi Yasuda,Tutomu YanagiAdv Clini Neurosci

    Adv Clini Neurosci   Vol. 2   page: 233-239   1992

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  188. 自律神経機能不全症における食事性低血圧発現の病態(2)一起立性低血圧との比較検討一 Reviewed

    平山正昭,伊藤慶太,長谷川康博,古池保雄,金桶吉起,櫻井信夫,鷲見幸彦,高橋 昭

    自律神経   Vol. 29   page: 375-382   1992

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  189. 自律神経機能不全症における食事性低血圧発現の病態(3)-β1刺激薬α1刺激薬併用による治療効果一 Reviewed

    平山正昭,古池保雄,金桶吉起,長谷川康博,渡辺英嗣,鷲見幸彦,櫻井信夫,高橋 昭

    自律神経   Vol. 29   page: 383-388   1992

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  190. 自律神経機能不全症における食事性低血圧発現の病態ー体内血流動態の測定ー Reviewed

    平山正昭,渡邊英嗣,古池保雄,長谷川康博,金桶吉起,櫻井信夫,白水重尚,杉山由樹,高橋 昭

    自律神経   Vol. 28   page: 487-493   1991

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  191. X-linked recessive bulbospinal neuronopathy‐A clinlicopathological study‐ Reviewed

    Gen Sobue,Yoshio Hashizume,Eiichiro Mukai,Masaaki Hirayama,Terumori Mitsuma,Akira Takahashi

    Brain   Vol. 1121   page: 209-232   1989

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  192. 球脊髄性筋萎縮症の1剖検例一特に薄東変性との関連に関して一 Reviewed

    平山正昭,橋詰良夫,高木維治,肥後晴代,伊藤雅文

    臨床神経   Vol. 28   page: 1131-1136   1988

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Books 19

  1. ヒトマイクロバイオーム Vol.2

    平山正昭、大野欽司( Role: Joint author ,  第3編 第5章 腸内細菌とパーキンソン病)

    エヌ・ティー・エス  2020.6 

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    Responsible for pages:269-274   Language:Japanese Book type:Scholarly book

  2. 【パーキンソン病(第2版)-基礎・臨床研究のアップデート-】検査・診断 自律神経障害とその機能検査法 発汗・皮膚血管系

    平山正昭( Role: Sole author)

    日本臨床  2018.5 

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    Language:Japanese

  3. 自律神経機能検査 第5版

    平山正昭 他( Role: Joint author)

    文光堂  2015.10  ( ISBN: 978-4-8306-1543-6

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    Language:Japanese

  4. GP・レジデントのためのパーキンソン病テキストブック

    山本光利、平山正昭、他( Role: Joint author)

    アルタ出版  2012.5 

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    Language:Japanese

  5. ガイドラインサポートハンドブック パーキンソン病

    平山正昭( Role: Joint author)

    医薬ジャーナル  2011.5 

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  6. パーキンソン病 臨床の諸問題2

    平山正昭( Role: Joint author)

    中外医薬社  2011 

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    Language:Japanese

  7. Parkinson's disease 2009

    平山正昭( Role: Joint author)

    アルタ出版  2009.11 

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    Language:Japanese

  8. パーキンソン病診療Q&A

    平山正昭( Role: Joint author)

    中外医薬品  2009.10 

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    Language:Japanese

  9. パーキンソン病 基礎・臨床研究のアップデート

    平山正昭( Role: Joint author)

    日本臨床  2009 

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    Language:Japanese

  10. 自律神経機能検査法

    平山正昭( Role: Sole author)

    文光堂  2007.7 

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    Language:Japanese

  11. ロバートソン自律神経学

    平山正昭( Role: Joint author)

    エルゼビア・ジャパン  2007.6 

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    Language:Japanese

  12. 脳神経外科体系 2 検査診断法

    平山正昭( Role: Joint author)

    中山書店  2006.4 

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    Language:Japanese

  13. パーキンソン病 臨床の諸問題

    平山正昭( Role: Joint author)

    中外医薬社  2006.3 

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  14. 食事性低血圧 新たな血圧異常の臨床

    平山正昭( Role: Sole author)

    南山堂  2004.5 

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  15. パーキンソン病 -病理学・自律神経系研究の進歩

    平山正昭( Role: Joint author)

    中外医薬社  2004.4 

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  16. 看護のための最新医学講座 脳・神経疾患

    平山正昭( Role: Joint author)

    中山書店  2002.2 

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  17. 自律神経機能検査法(第3版)

    平山正昭( Role: Joint author)

    文光堂  2000.11 

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  18. 自律神経機能検査法

    平山正昭( Role: Joint author)

    文光堂  2000 

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  19. 頭痛の診断と治療

    祖父江元,平山正昭,丹羽央佳( Role: Joint author)

    真興交易  1999 

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MISC 5

  1. 腸脳相関

    大野欽司、平山正昭

    Clinical neuroscience   Vol. 39 ( 7 ) page: 868 - 871   2021.7

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    Authorship:Last author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  2. パーキンソン病患者特有の腸内細菌叢の変化

    平山正昭、大野欽司

    バイオサイエンスとインダストリー   Vol. 79 ( 3 ) page: 230 - 231   2021.2

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  3. パーキンソン病における薬剤代謝と腸内細菌の関わり Invited

    平山正昭、大野欽司、勝野雅央 

    BRAIN and NERVE   Vol. 72 ( 7 ) page: 805 - 809   2020.7

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  4. 腸管とパーキンソン病 Invited

    平山正昭

    Clinical Neuroscience   Vol. 38 ( 7 ) page: 832 - 834   2020.7

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  5. パーキンソン病は腸管発症か?

    平山正昭

    MDSJ Letters   Vol. 13 ( 1 ) page: 4 - 6   2020

Presentations 131

  1. 腸内細菌と神経疾患 Invited

    平山正昭

    第58回日本臨床生理学会総会  2021.11.13 

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    Event date: 2021.11

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

  2. 消化管環境と自律神経 Invited

    平山正昭

    第74回日本自律神経学会総会  2021.10.23 

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    Event date: 2021.10

    Presentation type:Symposium, workshop panel (nominated)  

  3. パーキンソン病と腸内細菌 Invited

    平山正昭

    第15回パーキンソン病・運動障害疾患コングレス  2021.7.1 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:仙台市  

  4. パーキンソン病の進行は腸内細菌により予測ができる

    平山正昭、西脇寛、伊藤美佳子、浜口知成、勝野雅央、大野欽司、坪井義夫、前田哲也、柏原健一

    第15回パーキンソン病・運動障害疾患コングレス  2021.7.3 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:仙台市  

  5. 短鎖脂肪酸受容体がパーキンソン病マウスモデルに及ぼす効果の検討

    棚瀬支央里、浜口知成、木村郁夫、長谷耕二、大野欽司、平山正昭

    第62回日本神経学会学術大会  2021.5.22 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都市  

  6. 自律神経機能障害への対応

    平山正昭

    第20回高松国際パーキンソン病シンポジウム  2021.3.13 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

  7. αシヌクレインの凝集を誘発する物質の探索

    藤枝愛生、平山正昭

    第14回 パーキンソン病・運動障害疾患コングレス  2021.2.22 

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    Event date: 2021.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡市   Country:Japan  

  8. パーキンソン病患者における便秘と生活の工夫

    土井智子、竹原君江、中西啓介、平山正昭、本田育美

    第14回パーキンソン病・運動障害疾患コングレス  2021.2.22 

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    Event date: 2021.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡市   Country:Japan  

  9. パーキンソン病患者における便秘の重症度とQuality of life との関連

    土井智子、竹原君江、中西啓介、 平山正昭、本田育美

    第25回日本難病看護学会 第8回日本難病医療ネットワーク学会 合同学術集会  2020.11.20 

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    Event date: 2020.11

    Language:Japanese  

  10. Intestinal microbiota as biomarkers Invited

    Masaaki Hirayama

    0220.9.1 

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    Event date: 2020.8 - 2020.9

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  11. Relationship between intestinal bacteria, bacterial metabolites and residual pesticides in Parkinson's disease International conference

    Masaaki Hirayama,Tomohiro Ishida ,Momoka Kuki,Tomonari Hamaguchi2,Mikako Itho ,Tetsuya Maeda3,Kenichi Kashihara,Yoshio Tsuboi,Kinji Ohno ,Masahisa Katsuno

    The International Congress of Parkinson's Disease and Movement Disorders 2019 

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    Event date: 2019.9

    Language:English   Presentation type:Poster presentation  

    Venue:Nice   Country:France  

  12. Gut-Brain axis 腸内細菌とパーキンソン病 Invited

    平山正昭

    第13回パーキンソン病・運動障害疾患コングレス 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京都港区   Country:Japan  

  13. Lewy小体病患者のメタメタ解析を用いた腸内細菌叢の関与の解明

    平山正昭、西脇博、石田智大、九鬼桃茄、濵口 知成、伊藤美佳子、前田哲也、柏原健一、坪井義夫、大野欽司、勝野雅央

    第60回日本神経学会学術大会 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪市   Country:Japan  

  14. A good sleep, exercise and nutrition for your good QOL International conference

    Masaaki Hirayama

    Takamatsu International Symposium for PD & MD 

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    Event date: 2019.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:takamatsu   Country:Japan  

  15. Transcranial static magnetic stimulation over human primary motor cortex can modulate implicit motor learning International conference

    I.Nojima, T.Watanabe, M.Hirayama, H.Sugata, T.Ikeda, T.Mima

    NEUROSCIENCE 2018 

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    Event date: 2018.11

    Language:English   Presentation type:Poster presentation  

    Venue:San Diego   Country:United States  

  16. Gut microbiota geography in Parkinson disease in the world International conference

    Masaaki Hirayama, Mikako Ito, Tomonari Hamaguchi, Tomomi Minato, Tetsuya Maeda, Yoshio Tsuboi, Kenichi Kashihara, Kinji Ohno

    International Congress of Parkinson's Disease and Movement Disorders2018 

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    Event date: 2018.10

    Language:English   Presentation type:Poster presentation  

    Venue:Hong Kong   Country:China  

  17. 腸内細菌とパーキンソン病 Invited

    平山正昭

    第20回日本神経消化器病学会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:愛知県名古屋市   Country:Japan  

  18. The comparison of gut biogeography of the gut bacterial microbiota in Parkinson's disease International conference

    Hirayama M, Ito M, Minato T, Ohno K.

    23rd World Congress on Parkinson's Disease and Related Disorders 2018 

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    Event date: 2018.8

    Language:English   Presentation type:Poster presentation  

    Venue:Lyon   Country:Japan  

  19. パーキンソン病の腸内細菌組成 過去データとの比較

    平山正昭、湊 智美、伊藤美佳子、浜口知成 、前田哲也、勝野雅央 、大野欽司

    第12回パーキンソン病・運動障害疾患コングレス 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都市   Country:Japan  

  20. パーキンソン病の消化管障害−特に便秘に関して

    平山正昭

    第12回パーキンソン病・運動障害疾患コングレス 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:京都市   Country:Japan  

  21. 同居人を対照としたパーキンソン病患者における腸内細菌叢の変化

    瀧本圭一, 伊藤美佳子, 濵口知成, 武田淳一, 大野欽司, 平山正昭

    第12回パーキンソン病・運動障害疾患コングレス 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都市   Country:Japan  

  22. 消化管の自律神経障害に伴うパーキンソン病の臨床症状と病態

    平山正昭

    第59回日本神経学会学術大会 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:札幌市   Country:Japan  

  23. Parkinson 病に対する水素水の多施設共同二重盲検並行群間試験

    頼高朝子,大塚千久美,前田哲也,平山正昭 ,阿部隆志,渡辺宏久 ,斉木英資 ,大山彦光 ,深江治郎,下泰司 ,波田野琢, 河尻澄宏 ,大熊泰之,町田裕 ,三輪英人,鈴木智香子,風間明日香 ,冨山誠彦 ,木原武士,平澤基之,志村秀樹,小田英世 ,服部信孝

    第7回日本分子状水素医学生物学会大会 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  24. パーキンソン病(PD) 患者に対する酸化アルブミンを用いたバイオマーカー としての有用性

    瀧本圭一,湊智美,上山純,伊藤美佳子,大野欽司,平山正昭

    第11回パーキンソン病・運動障害疾患コングレス 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  25. Differences of gut bacterial community relateto pathology progress in Parkinson's disease International conference

    Masaaki Hirayama, Tomomi Minato, Suzuki Anzu, Satoru Hasegawa, Yoshiro Fujisawa, Hirokazu Tsuji, Takashi Asahara, Koji Nomoto, Akira Okamoto, Tetsuya Maeda, Kinji Ohno

    XXIII World Congress of Neurology 

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    Event date: 2017.9

    Language:English   Presentation type:Poster presentation  

    Venue:kyoto   Country:Japan  

  26. Autonomic dysfunction in dementia - overview Invited International conference

    M.Hirayama

    International Society for Autonomic Neuroscience2017 

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    Event date: 2017.8 - 2917.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:nagoya   Country:Japan  

  27. Gastrointestinal dysfunction in Parkinson's disease Invited International conference

    M.Hirayama

    International Society for Autonomic Neuroscience2017 

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    Event date: 2017.8 - 2017.9

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:nagoya   Country:Japan  

  28. 第28回日本末梢神経学会学術集会

    平山正昭

    下肢の神経伝導検査 

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    Event date: 2017.8

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:名古屋市   Country:Japan  

  29. Two-year prospective study reveals that gut dysbiosis predicts progression of Parkinsons disease International conference

    Tomomi Minato, Yoshiro Fujisawa, Hirokazu Tsuji, Takashi Asahara, Koji Nomoto, Akira Okamoto, Tetsuya Maeda, Kinji Ohno, Masaaki Hirayama

    21th International Congress of the International Parkinson and Movement Disorder Society 

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    Event date: 2017.6

    Language:English   Presentation type:Poster presentation  

    Venue:Vancouver   Country:Canada  

  30. Clinical benefits and optimal dosage of Istradefylline in Parkinsons disease International conference

    Tetsuya Maeda, Kenichi Kashihara, Masaaki Hirayama

    13th International Conference on Alzheimer's and Parknson's Disases 

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    Event date: 2017.3 - 2017.4

    Language:English   Presentation type:Poster presentation  

    Venue:Vienna   Country:Austria  

  31. Microbiota and Neurodegenerative diseases Invited International conference

    Parkinson's Disease Symposium in Takamatsu 2017 

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    Event date: 2017.2

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:takamatsu   Country:Japan  

  32. 失語症状で発症した原発性中枢神経血管炎の1例

    遠藤邦幸, 平山哲之, 川頭祐一, 伊藤瑞規, 熱田直樹, 平山正昭, 勝野雅央

    第34回日本神経治療学会総会 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:米子市   Country:Japan  

  33. パーキンソン病患者における腸内細菌叢の変動と主要菌種の水素産生量測定 International conference

    鈴木杏, 長谷川聖, 大野欽司, 浅川晋, 馬場竜子, 平山正昭

    第10回 パーキンソン病・運動障害疾患コングレス 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都市   Country:Japan  

  34. 腸内細菌叢の変化がパーキンソン病の病態進展速度に与える影響

    湊智美,鈴木杏,長谷川聖,藤澤嘉朗,辻浩和,朝原崇,野本康二,岡本陽,前田哲也,大野欽司,平山正昭

    第10回 パーキンソン病・運動障害疾患コングレス 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都市   Country:Japan  

  35. パーキンソン病における嗅覚障害と心血管系自律神経障害の経時的変化の検討

    上田美紀,鈴木将史, 中村友彦,平山正昭, 勝野雅央

    第10回 パーキンソン病・運動障害疾患コングレス 

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    Event date: 2016.10

    Language:English   Presentation type:Poster presentation  

    Venue:京都市   Country:Japan  

  36. パーキンソン病の起立性低血圧とBMIとの関連

    中村 友彦, 鈴木 将史, 上田 美紀, 平山 正昭, 勝野 雅央

    第10回 パーキンソン病・運動障害疾患コングレス 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都市   Country:Japan  

  37. 多系統萎縮症における心臓副交感神経機能の検討 International conference

    鈴木将史,中村友彦, 上田美紀,平山正昭, 勝野雅央

    第10回 パーキンソン病・運動障害疾患コングレス 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都市   Country:Japan  

  38. Perception gap for the motor and non-motor symptom between patients with Parkinson's disease and caregivers International conference

    Tomomi Minato, Anzu Suzuki, Sae Goto, Tetsuya Maeda, Kenichi Kashihara, Atsushi Takeda, Masaaki Hirayama

    4th World Parkinson Congress 

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    Event date: 2016.9

    Language:English   Presentation type:Poster presentation  

    Venue:Portland   Country:United States  

  39. Differences of gut bacterial community relate to pathology progress in Parkinson's disease International conference

    Tomomi Minato, Satoru Hasegawa, Yoshiro Fujisawa, Hirokazu Tsuji, Takashi Asahara, Koji Nomoto, Akira Okamoto, Tetsuya Maeda, Kinji Ohno, Masaaki Hirayama

    20th International Congress of the International Parkinson and Movement Disorder Society 

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    Event date: 2016.6

    Language:English   Presentation type:Poster presentation  

    Venue:Berlin   Country:Germany  

  40. パーキンソン病患者における腸内細菌叢の変動と主要菌種の水素産生量測定

    鈴木杏, 湊智美, 長谷川聖, 藤澤嘉朗, 大野欽司, 浅川晋, 馬場竜子,平山正昭

    第57回日本神経学会学術大会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸市   Country:Japan  

  41. 起立性低血圧を来すパーキンソン病の自然歴の検討

    中村友彦,上田美紀, 鈴木将史,岡田暁典, 渡辺宏久,平山正昭, 勝野雅央,祖父江元

    第57回日本神経学会学術大会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸市   Country:Japan  

  42. 腸内細菌叢の変化がパーキンソン病の病態進展速度に与える影響

    湊智美,鈴木杏,長谷川聖,藤澤嘉朗,辻浩和,朝原崇,野本康二,岡本陽,前田哲也,大野欽司,平山正昭

    第57回日本神経学会学術大会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸市   Country:Japan  

  43. パーキンソン病における嗅覚障害と心血管系自律神経障害の経時的変化の検討

    上田美紀,鈴木将史, 岡田暁典,中村友彦, 平山正昭,勝野雅央, 祖父江元

    第57回日本神経学会学術大会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸市   Country:Japan  

  44. 尿中8-OHdGを用いたゾニサミドによるパーキンソン病の酸化的ストレスの抑制効果

    平山正昭, 湊智美, 前田哲也,中村友彦, 勝野雅央

    第57回日本神経学会学術大会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸市   Country:Japan  

  45. パーキンソン病の睡眠障害とメラトニン分泌の関連についての検討

    鈴木将史,中村友彦, 上田美紀,岡田暁典, 長谷川聖,平山正昭, 勝野雅央

    第57回日本神経学会学術大会 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸市   Country:Japan  

  46. 酸化ストレスの発生と制御 発がんと老化の抑制をめざして パーキンソン病への水素水の効果 無作為化二重盲検並行群間試験から

    頼高朝子,高梨雅史, 平山正昭,中原登志樹,太田成男,服部信孝

    第39回日本分子生物学会年会・第89回日本生化学会大会 合同大会 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  47. 高齢パーキンソン病患者の睡眠障害に対するロチゴチンの効果

    鈴木将史,中村友彦,上田美紀,岡田暁典,渡辺宏久,平山正昭,祖父江元

    第33回日本神経治療学会総会 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  48. パーキンソン病の起立性低血圧に対するグレリン、レプチンの検討

    中村友彦,上田美紀, 鈴木将史,岡田暁典,平山正昭,祖父江元

    第33回日本神経治療学会総会 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  49. パーキンソン病の補助診断としての自律神経の役割 循環機能

    中村友彦,平山正昭

    第68回日本自律神経学会総会 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  50. ラクツロース負荷による大腸内水素産生はパーキンソン病では障害されている

    平山正昭,湊智美,鈴木杏,藤澤嘉朗,長谷川聖,中村友彦,勝野雅央

    第68回日本自律神経学会総会 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  51. パーキンソン病患者における腸内細菌叢の変動と主要菌種の水素産生量測定

    鈴木杏, 長谷川聖, 大野欽司, 浅川晋, 馬場竜子,平山正昭

    第9回パーキンソン病・運動障害疾患コングレス 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  52. パーキンソン病患者と家族の症状認識についての検討

    湊知美,後藤沙絵,前田哲也,柏原健一,武田篤,平山正昭

    第9回パーキンソン病・運動障害疾患コングレス 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  53. The changes of the visual evoked magnetic field using the magnetoencephalography and its connectivity using MRI in aging and Parkinson's disease International conference

    19th International Congress of Parkinson's Disease and Movement Disorders 

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    Event date: 2015.6

    Language:English   Presentation type:Poster presentation  

    Venue:San Diego   Country:United States  

  54. Observation of changes in aging and Parkinson's disease in the visual stimulus by using the MEG

    Yoshiro Fujisawa, Masaaki Hirayama ,Sumio Yamada, Junichi Ueyama, Minoru Hoshiyama

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    Event date: 2015.5 - 2915.5

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  55. Perception gap for the motor and non-motor symptom between patients with Parkinson's disease and caregivers

    Tomomi Minato, Yoshiro Fujisawa, Satoru Hasegawa, Anzu Suzuki, Tetsuya Maeda, Kenichi Kashihara, Masaaki Hirayama

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    Event date: 2015.5

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  56. パーキンソン病の早期診断マーカーとしての血液中、汗中バイオマーカーの検討

    平山正昭,角田誠,山本光利,津田孝雄,大野欽司

    第56回日本神経学会学術大会 

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    Event date: 2015.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  57. The changes in aging and Parkinson's disease in the visual stimulus by using the MEG International conference

    Yoshiro Fujisawa, Sae Goto, Jun-ichi Uemura, Sumio Yamada, Minoru Hoshiyama, Masaaki Hirayama

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    Event date: 2015.3

    Language:English   Presentation type:Poster presentation  

    Country:Taiwan, Province of China  

  58. The change of intestinal microbiota may contribute to clinical feature of Parkinson's disease International conference

    Hasegawa S, Fujiwasa Y, Tsuji H, Asahara T, Nomoto K, Okamoto A, Shibata A, Ohno K, Hirayama M

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    Event date: 2015.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  59. パーキンソン病疾患の皮膚ガス成分の特徴とGC/MSフラグメントからの重度の推定

    津田 孝雄, 平山 正昭, 角田 誠, 大野 欽司

    第135回日本薬学会年会 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  60. パーキンソン病患者血中L-Dopa濃度の汗試料測定による非侵襲モニタリング

    角田 誠, 平山 正昭, 津田 孝雄, 大野 欽司

    第135回日本薬学会年会 

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    Event date: 2015.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  61. Perception gap for the motor and non-motor symptom between patients with Parkinson's disease and caregiver International conference

    Masaaki Hirayama, Tomomi Minato, Tetsuya Maeda, Kenichi Kashihara

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    Event date: 2014.12

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  62. 神経内科領域における心循環調節障害の病態と治療 食事性低血圧(PPH)

    平山 正昭

    第32回日本神経治療学会総会 

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    Event date: 2014.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  63. パーキンソン病における温熱刺激閾値の検討

    岡田 暁典, 中村 友彦, 平山 正昭, 祖父江 元

    第67回日本自律神経学会総会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  64. 自律神経不全症と瞳孔機能異常

    平山 正昭

    第67回日本自律神経学会総会 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  65. パーキンソン病の心血管系自律神経障害におけるグレリン、レプチンの関与の検討

    中村 友彦, 鈴木 将史, 岡田 暁典, 鈴木 淳一郎, 長谷川 聖, 平山 正昭, 祖父江 元

    第8回パーキンソン病・運動障害疾患コングレスプログラム 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  66. 多系統萎縮症の末梢血管抵抗の反応性 Head-up tilt試験、ノルアドレナリン負荷試験を通して

    鈴木 淳一郎, 鈴木 将史, 岡田 暁典, 中村 友彦, 平山 正昭, 祖父江 元

    第8回パーキンソン病・運動障害疾患コングレスプログラム 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  67. パーキンソン病で便秘は血中の腸内細菌関連物質を増加させる

    長谷川 聖, 藤澤 嘉朗, 大野 欽司, 平山 正昭

    第8回パーキンソン病・運動障害疾患コングレスプログラム 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  68. パーキンソン病における心臓副交感神経機能とMIBG心筋シンチグラフィーとの関連の検討

    鈴木 将史, 中村 友彦, 岡田 暁典, 鈴木 淳一郎, 平山 正昭, 祖父江 元

    第8回パーキンソン病・運動障害疾患コングレスプログラム 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  69. 視覚刺激における脳磁図を用いた加齢および疾患における影響

    藤澤 嘉朗, 平山 正昭, 山田 純生, 上村 純一, 寳珠山 稔

    第8回パーキンソン病・運動障害疾患コングレスプログラム 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  70. パーキンソン病における痛み関連脳電位と認知機能との関連性

    岡田 暁典, 中村 友彦, 鈴木 将史, 鈴木 淳一郎, 平山 正昭, 祖父江 元

    第8回パーキンソン病・運動障害疾患コングレスプログラム 

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    Event date: 2014.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  71. 手根管症候群患者における体性感覚誘発脳反応の回復曲線の検討

    岩月 克之, 中野 智則, 石井 久雄, 倉橋 俊和, 水島 秀幸, 栗本 秀, 山本 美知郎, 平田 仁, 寳珠山 稔, 吉田 彬人, 篠原 孝明, 上村 純一, 平山 正昭

    第25回日本末梢神経学会 

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    Event date: 2014.8

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  72. Oxdative stress maker (urinary 8-hydroxy-2-deoxyguanosine) was modified by treatment of various Parkinson’s drug International conference

    Masaaki Hirayama, Sae Goto, Tomohiko Nakamura, Yasuaki Mizutani, Jun-ichiro Suzuki, Hirohisa Watanabe, Gen Sobue

    movement disorder congress 

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    Event date: 2014.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Sweden  

  73. 多系統萎縮症の末梢血管抵抗の反応性 Head-up tilt試験、ノルアドレナリン負荷試験を通して

    鈴木, 淳一郎 鈴木, 将史 岡田, 暁典 中村, 友彦 平山, 正昭 祖父江, 元

    日本神経学会 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  74. パーキンソン病患者におけるうつの誘発脳電位を用いた検討

    水谷泰彰, 岡田 暁典, 鈴木 淳一郎, 中村 友彦, 平山 正昭, 祖父江 元

    日本神経学会 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  75. 自律神経障害

    平山正昭

    第3回日本パーキンソン病・運動障害疾患学会教育研修会 

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    Event date: 2014.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  76. パーキンソン病の病態と治療

    前田哲也、平山正昭

    宮古島神経科学カンファレンス2013 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  77. 脳磁図を用いた若年者と高齢者における連続痛覚刺激に対する抑制反応

    平山正昭、後藤沙絵、岡田有以、寳珠山稔

    第43回日本臨床神経生理学会学術大会 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  78. 失神と自律神経障害

    平山正昭

    第66回日本自律神経学会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  79. 多系統萎縮症のhead-up tilt試験における末梢血管抵抗変化と起立性低血圧との関連

    岡田, 暁典 鈴木, 淳一郎 水谷, 泰彰 中村, 友彦 平山, 正昭 祖父江, 元

    日本自律神経学会総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  80. パーキンソン病では早期から嗅覚機能と心血管系自律神経機能が並行して障害される

    水谷 泰彰 岡田 暁典 鈴木 淳一郎 中村 友彦 平山 正昭 祖父江 元

    日本自律神経学会 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  81. 123I-meta-iodobenzylguanidine(MIBG)心筋シンチグラフィー

    渡辺 宏久 中村 友彦 平山 正昭 祖父江 元

    日本自律神経学会総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  82. パーキンソン病における起立時末梢血管収縮不全を来す背景因子に関する検討

    中村 友彦 岡田 暁典 鈴木 淳一郎 水谷 泰彰 平山 正昭 祖父江元

    日本自律神経学会総会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  83. 尿中8-OHdGを用いたパーキンソン病における酸化的ストレスの変化

    平山正昭、後藤沙絵、中村友彦、水谷泰彰、鈴木淳一郎、渡邊宏久、祖父江元

    The 7th パーキンソン病・運動障害疾患コングレ 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  84. 非運動症状から考えるパーキンソン病

    平山正昭

    第13回釧路ニューロサイエンスワークショップ 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:釧路   Country:Japan  

  85. Visual cortex activating studies using magnetoencephalography gram in Parkinson's disease: Effect of aging and disease specificity International conference

    17th International Congress of Parkinson's Disease and Movement Disorders 

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    Event date: 2013.6

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  86. 視覚刺激における脳磁図を用いた加齢および疾患における影響

    後藤沙絵、岡田有以、平山正昭、寳珠山稔

    第55回日本神経学会学術大会 

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    Event date: 2013.5 - 2013.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  87. guideline in the practice International conference

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  88. 水素水投与は筋萎縮性側索硬化症モデルマウスの発症を遅らせる

    岡田有以 ,伊藤美佳子 ,後藤沙絵 ,大野欽司,平山正昭

    第3回分子状水素医学シンポジウム 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  89. パーキンソン病患者における水素水の無作為化二重盲検併行群間試験

    頼高朝子 , 高梨雅史 , 平山正昭 , 中原登志樹 , 太田成男 , 服部信孝

    第3回分子状水素医学シンポジウム 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  90. 血圧と自律神経障害 神経疾患の起立性低血圧

    中村 友彦, 平山 正昭, 祖父江 元

    第65回日本自律神経学会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  91. 正中神経末梢神経伝導検査において著明な潜時延長を認めた一例

    榊原 久美子, 平山 正昭, 中村 友彦, 住田 佳陽, 吉子 健一, 松本 祐之, 飯島 正博, 祖父江 元

    第23回日本末梢神経学会 

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    Event date: 2012.8 - 2012.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  92. パーキンソン病患者における痛覚関連電位

    岡田 有以, 後藤 沙絵, 平山 正昭, 原 敬史, 濱 哲夫, 中村 友彦, 祖父江 元

    第23回日本末梢神経学会 

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    Event date: 2012.8 - 2012.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:福岡   Country:Japan  

  93. 感覚神経伝導速度を用いた球脊髄性筋萎縮症と筋萎縮性側索硬化症の鑑別

    後藤 沙絵, 岡田 有以, 平山 正昭, 濱 哲夫, 中村 友彦, 勝野 雅央, 坂野 晴彦, 鈴木 啓介, 祖父江 元

    第23回日本末梢神経学会 

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    Event date: 2012.8 - 2012.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  94. Impaired cardiac response and its relationship with orthostatic hypotension in Parkinson's disease International conference

    Tomohiko Nakamura, Takashi Hara, Yasuaki Mizutani, Hirohisa Watanabe, Masaaki Hirayama, Gen Sobue

    16th International Congress of Parkinson's Disease and Movement Disorders 

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    Event date: 2012.6

    Language:English   Presentation type:Poster presentation  

    Country:Ireland  

  95. Impaired pain processing in Parkinson's disease and its relative association with the sense of smell International conference

    Masaaki Hirayama, Takashi Hara, Yasuaki Mizutani, Tetsuo Hama , Norio Hori Tomohiko Nakamura, Shigenori Kato, Hirohisa Watanabe,Gen Sobue

    16 th international congress of Parkinson7S disease and movement disorders 

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    Event date: 2012.6

    Language:English   Presentation type:Poster presentation  

    Country:Ireland  

  96. 早期パーキンソン病における嗅覚障害と自律神経障害の関連

    水谷 泰彰, 原 敬史, 中村 友彦, 平山 正昭, 渡辺 宏久, 祖父江元

    第52回日本神経学会学術大会 

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    Event date: 2012.5 - 2121.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  97. 心収縮力変化から見たパーキンソン病における心臓交感神経障害と起立性低血圧の関連

    中村 友彦, 水谷 泰彰, 原 敬史, 平山 正昭, 渡辺 宏久, 祖父江 元

    第52回日本神経学会学術大会 

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    Event date: 2012.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

    1-110/3-平山正昭

  98. パーキンソン病患者における痛み関連脳電位の検討

    原 敬史, 水谷 泰彰, 中村 友彦, 渡辺 宏久, 平山 正昭, 祖父江 元

    第52回日本神経学会学術大会 

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    Event date: 2012.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

    1-110/3-平山正昭

  99. パーキンソン病の自律神経進展形式の検討

    平山正昭

    第53回日本神経学会総会 

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    Event date: 2012.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  100. A case of MSA which presented a uniquw snore with a vibrato International conference

    Katsuo Kimura, Tokmohiko Nakamura, Masaaki Hirayama ,Gen Sobue

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    Event date: 2012.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  101. 瞳孔機能障害とその検査法-神経変性疾患を中心にして-

    平山正昭

    日本自律神経学会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:秋田   Country:Japan  

  102. 一側上下肢の脱力、筋肥大、不随意運動を呈した抗VGKC抗体陽性の治療例(

    野田智子, 中西浩隆, 川頭祐一, 熱田直樹, 中村友彦, 渡辺宏久, 平山正昭, 祖父江元, 細井泰志, 渡邊修

    日本神経治療学会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  103. 多系統萎縮症 分類および病態生理

    平山正昭

    movement disorder society japan  

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  104. パーキンソン病における自律神経障害の経時的変化の検討(

    平山 正昭

    第65回日本神経治療学会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  105. 球脊髄性筋萎縮症における中枢伝導時間

    鈴木啓介、勝野雅央、坂野晴彦、須賀徳明、橋詰淳、原敬史、濱哲夫、中村友彦、平山正昭、祖父江元

    第52回日本神経学会学術大会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋   Country:Japan  

  106. STN-DBS後に生じた言語障害に対するLee Silverman voice treatmentの有用性

    渡邊宏久、田中康博、宮崎雄、熱田直樹、伊藤瑞規、千田譲、平山正昭、梶田泰一、辰巳寛、山本正彦、祖父江元

    第52回日本神経学会学術大会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  107. 日中過眠を伴うパーキンソン病患者の大脳灰白質と皮質化の萎縮

    加藤重典、渡邊宏久、中村亮一、熱田直樹、伊藤瑞規、千田譲、平山正昭祖父江元

    第52回日本神経学会学術大会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  108. パーキンソン病における近見反応の検討

    原敬史、中村友彦、濱哲夫、渡邊宏久、平山正昭、祖父江元

    第52回日本神経学会学術大会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  109. パーキンソン病における自律神経障害の経時変化

    中村友彦、原敬史、濱哲夫、渡邊宏久、平山正昭、祖父江元

    第52回日本神経学会学術大会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  110. パーキンソン病における痛み関連電位および皮質SEP International conference

    濱哲夫、平山正昭、原敬史、中村友彦、祖父江元

    第52回日本神経学会学術大会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  111. パーキンソン病における幻覚、認知、尿中8-OHdGと脳萎縮

    平山正昭、新美芳樹、辻本昌史、石原哲朗、川合圭成、千田譲、中村友彦、渡邊宏久、祖父江元

    第52回日本神経学会学術大会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  112. Correlations between fatigue and cardiovascular autonomic dysfunction in Parkinson's disease International conference

    Tomohiko Nakamura, Takashi Hara, Tetsuo Hama, Hirohisa Watanabe, Masaaki Hirayama, Gen Sobue

    Asian and Oceanian Parkinson's disease and movement disorder 

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    Event date: 2011.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  113. PAIN RELATED SEP AND CORTICAL SEP IN PARKINSON'S DISEASE International conference

    Masaaki HIRAYAMA, Tetsuo HAMA, Takashi HARA, Tomohiko NAKAMURA, Gen SOBUE

    Asian and Oceanian Parkinson's disease and movement disorder 

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    Event date: 2011.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Taiwan, Province of China  

  114. abnormal breath hydrogen production by ingestion of lactulose in Parkinson's disease

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  115. autonomic failure in Parkinson's disease International conference

    Masaaki Hirayama

    International Parkinson's disease symposium in Takamatsu 

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    Event date: 2011.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  116. 神経系疾患における眼・視領域の症候 Parkinson' s diseaseにおける瞳孔調節異常

    平山正昭

    日本神経眼科学会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  117. PAIN RELATED SEP AND CORTICAL SEP IN PARKINSON'S DISEASE International conference

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    Event date: 2010.10 - 2010.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  118. The sensory nerve conduction study is beneficial to distinguish bulbar and spinal muscular atrophy from Amyotrophic lateral sclerosis International conference

    Masaaki Hirayama, Tetsuo Hama, Tomohiko Nakamura, Keisuke Suzuki, Haruhiko Bannno, Masaomi Katsuno, Fumiaki Tanaka, Gen Sobue

    international congress of clinical neurophysiology 

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    Event date: 2010.10 - 2010.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  119. パーキンソン病患者における近見反応の検討

    原 敬史,濱 哲夫,中村 友彦,平山 正昭,祖父江 元

    日本自律神経学会 

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    Event date: 2010.10 - 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  120. パーキンソン病自律神経障害のすべて~専門家によるリレーセッション

    平山正昭

    日本自律神経学会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  121. パーキンソン病における疲労と自律神経障害との関連の検討

    中村 友彦,原 敬史,濱 哲夫,平山 正昭,祖父江 元

    日本自律神経学会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  122. LSVT 法を応用した音楽療法の試み

    鵜飼久美子, 平山正昭

    パーキンソン病・運動障害疾患コングレス 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  123. パーキンソン病の自律神経障害(排尿障害、発汗)発汗(基礎と臨床)

    平山正昭

    パーキンソン病運動障害コングレス 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  124. Progressive supranuclear palsy-parkinsonism(PSP-P)の一剖検例

    渡邊宏久、平山正昭

    パーキンソン病・運動障害疾患コングレス 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  125. パーキンソン病における疲労と自律神経障害との関連の検討

    中村友彦、平山正昭

    パーキンソン病・運動障害疾患コングレス 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  126. パーキンソン病患者における近見反応の検討

    原 敬史,濱 哲夫,中村 友彦,平山 正昭,祖父江 元

    パーキンソン病・運動障害疾患コングレス 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  127. パーキンソン病における痛み関連脳電位及び皮質SEP

    濱 哲夫,原 敬史,中村 友彦,平山 正昭,祖父江 元

    パーキンソン病・運動障害疾患コングレス 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  128. パーキンソン病における飽和水素水とラクツロース負荷での呼気中水素濃度の推移

    平山 正昭,大野欽司, 原 敬史,濱 哲夫,中村 友彦,平山 正昭,祖父江 元

    パーキンソン病・運動障害疾患コングレス 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  129. 視床下核深部脳刺激術後に言語障害を来したパーキンソン病に対するLSVT の効果

    渡邊宏久、平山正昭

    パーキンソン病・運動障害疾患コングレス 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  130. パーキンソン病の酸化ストレスマーカとしての8-OHdG はパーキンソン病の 運動非運動症状の重症度と相関する

    平山 正昭,大野欽司, 原 敬史,濱 哲夫,中村 友彦,平山 正昭,祖父江 元

    パーキンソン病・運動障害疾患コングレス 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  131. パーキンソン病における幻覚と尿中8-OHdG の関連

    新美芳樹, 平山正昭, 祖父江元

    パーキンソン病・運動障害疾患コングレス 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 3

  1. パーキンソン病の起因となる腸管α-synuclein異常蓄積に対する腸内細菌叢の関与の解明

    2016.10

    国立研究開発法人AMED革新的先端研究開発支援事業「パーキンソン病の起因となる腸管α-synuclein異常蓄積に対する腸内細菌叢の関与の解明 

    大野欽司

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    Grant type:Competitive

    パーキンソン病の起因となる腸管α-synuclein異常蓄積に対する腸内細菌叢の関与の解明

  2. パーキンソン病、モデル動物における腸管内細菌叢変動の測定

    2013.4

    国内共同研究 

  3. 超早期診断技術開発プロジェクト

    2012.4 - 2013.3

    「知の拠点あいち」重点研究プロジェクト研究 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 唾液メラトニン測定によるパーキンソン病における睡眠障害のバイオマーカー開発

    2016.4 - 2019.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  2. 高齢者、パーキンソン病患者における抑制系回路の加齢および疾患による変化

    2015.4 - 2018.3

    科学研究費補助金  基盤研究(C)

    平山正昭

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    Authorship:Principal investigator 

    人の脳研究は脳拡散画像、安静時機能的MRI、安静時脳磁図を用いることで、 マクロレベルの脳内神経回路可視
    化をもたらした。しかし、これらの多くは、興奮性の増加による血流変化や脳萎縮や白質変性などの機能低下を
    観察するものが多い。生体の調節は、実際には抑制系の細胞により興奮神経のフィードバック、フィードフォー
    ワード制御で精緻な運動制御や感覚認知を調節している。加齢に伴う抑制系の低下は、精神面では反社会的行動
    、運動感覚系では微細な認知、行動の低下を生じる。我々は、パーキンソン病の研究を通し、加齢変化の重要性
    と疾患特異的な変化を同時に解明する必要性を認識した。そこで、抑制系の反応のバイオマーカーの加齢や神経
    変性疾患との関連を明らかにするために、脳磁図、MRIによる抑制系システムの解明を試みる。

  3. パ-キンソン病における視覚感覚野を中心とした幻覚発症機序と非運動症状の関連

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

    平山正昭

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    Authorship:Principal investigator 

  4. パーキンソン病の心血管自律神経障害のグレリンとレプチンの関与の解明と治療への展望

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  5. 早期パーキンソン病の精神症状に対する抗コリンエステラーゼ阻害剤の有用性

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  6. 音楽療法を応用した構音障害 改善のためのボイストレーニング

    2010.4 - 2012.3

    科学研究費補助金  科学研究費補助金(科研費)課題 №22650169

    鵜飼久美子

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    Authorship:Coinvestigator(s) 

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Industrial property rights 2

  1. パーキンソン病の判定 マーカーおよび判定方法

    平山正昭、大野欽司、辻浩和、朝原崇、野本康二

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    Application no:特願2017-098973号  Date applied:2017.5

    Country of applicant:Domestic  

  2. パーキンソン病の判定基準とする方法

    津田孝雄、大野欽司、平山正昭、角田誠

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    Applicant:津田孝雄

    Application no:特願2013-206769  Date applied:2013.9

    Patent/Registration no:6383920  Date registered:2018.8 

    Country of applicant:Domestic  

 

Teaching Experience (On-campus) 6

  1. 生物学実験

    2021

  2. 医療英語IIB

    2021

  3. 医療英語IB

    2021

  4. 臨床病理学演習

    2020

  5. 医療英語IB

    2020

  6. 基礎セミナーA

    2020

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Social Contribution 18

  1. 愛知県パーキンソン病友の会

    Role(s):Advisor, Contribution

    2015.4

  2. 日本神経学会主催市民公開講座

    2015.9

  3. 愛知県長久手パーキンソン病講演会

    2015.2

  4. 多治見市パーキンソン病医療講演会

    2015.1

  5. 愛知県パーキンソン病友の会講演会

    2015.1

  6. 宮古島市民公開講座

    2014.11

  7. 宮古島医療講演会

    2014.11

  8. 愛知県パーキンソン病友の会一泊旅行同行

    2014.11

  9. 秋田県パーキンソン病講演会

    2014.10

  10. 愛知県パーキンソン病友の会講演会

    2014.10

  11. 音楽療法学会講演会

    2014.9

  12. 香川県パーキンソン病友の会講演会

    2014.9

  13. 愛知県パーキンソン病友の会講演会

    2014.7

  14. 愛知県パーキンソン病友の会講演会

    2014.4

  15. 愛知県パーキンソン病友の会講演会

    2014.1

  16. 愛知県パーキンソン病友の会一泊旅行同行

    2013.11

  17. 愛知県パーキンソン病友の会講演会

    2013.7

  18. 愛知県パーキンソン病友の会講演会

    2013.4

▼display all

Media Coverage 1

  1. コロナ低死亡率、腸内細菌関連か アジアや北欧特有 Internet

    共同通信  2022.1

Academic Activities 3

  1. 第20回 PDナース研修会

    Role(s):Panel moderator, session chair, etc.

    MDSJ  2021.11

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    Type:Academic society, research group, etc. 

  2. Nagoya Journal of Medical Science

    Role(s):Peer review

    2021.9 - 2022.2

     More details

    Type:Peer review 

    3件

  3. JST創発的研究支援事業

    Role(s):Review, evaluation

    2021.5

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    Type:Scientific advice/Review