Faculty Profiles - TAMAKOSHI, Koji

Papers - TAMAKOSHI, Koji

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Sleep stage, sleep fragmentation and heart rate variability during the initial 3-h sleep period in patients with obstructive sleep apnea syndrome

Moriwaki, Y; Nakayama, N; Ooshima, C; Akahori, M; Wakai, M; Tamakoshi, K; Hirai, M

SLEEP AND BIOLOGICAL RHYTHMS 2025.1

Association between milk consumption in middle age and frailty in later life: The Aichi Workers' cohort study

Hong, YJ; Otsuka, R; Song, Z; Fukuda, C; Tajima, R; Lin, JY; Hibino, M; Kobayashi, M; He, YP; Matsunaga, M; Ota, A; Nakano, Y; Li, YY; Tamakoshi, K; Yatsuya, H

GERIATRICS & GERONTOLOGY INTERNATIONAL Vol. 24 ( 7 ) page： 700 - 705 2024.7

Impact of perineal pain and delivery related factors on interference with activities of daily living until 1 month postpartum: A longitudinal prospective study Reviewed

Yamada, A; Takahashi, Y; Usami, Y; Tamakoshi, K

BMC PREGNANCY AND CHILDBIRTH Vol. 24 ( 1 ) page： 446 2024.6

In-service educational learning factors related to nursing competence among new nurses Reviewed

Hoshino, J; Tamakoshi, K; Hotta, M; Muto, S; Furukawa, N

COLLEGIAN Vol. 31 ( 2 ) page： 100 - 106 2024.4

Associations of overweight and obesity with the risk of cardiovascular disease according to metabolic risk factors among middle-aged Japanese workers: The Aichi Workers' cohort study Reviewed

Al-shoaibi, AAA; Li, YY; Chiang, CF; Nakano, Y; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Yatsuya, H

OBESITY RESEARCH & CLINICAL PRACTICE Vol. 18 ( 2 ) page： 101 - 108 2024.3

Factors associated with perineal pain on the first postnatal day after vaginal delivery: a cross-sectional study of primiparous women Reviewed

Yamada, A; Takahashi, Y; Hirose, M; Usami, Y; Maruya, S; Tamakoshi, K

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 86 ( 1 ) page： 52 - 63 2024.2

Nonrestorative Sleep and Type 2 Diabetes Incidence: the Aichi Workers' Cohort Study

Lin, JY; Song, Z; Li, YY; Chiang, CF; Hirakawa, Y; Nakano, Y; Hong, YJ; Matsunaga, M; Ota, A; Tamakoshi, K; Yatsuya, H

JOURNAL OF EPIDEMIOLOGY 2024.1

Association of psychological factors with advanced-level functional competency: Findings from the Aichi workers' cohort study, 2002-2019

Saif-Ur-Rahman, K; Hong, YJ; Li, YY; Matsunaga, M; Song, Z; Shimoda, M; Al-Shoaibi, A; He, YP; Mamun, MR; Hirano, Y; Chiang, CF; Hirakawa, Y; Aoyama, A; Tamakoshi, K; Ota, A; Otsuka, R; Yatsuya, H

HELIYON Vol. 9 ( 11 ) page： e21931 2023.11

Modification of the association between nausea and vomiting of pregnancy and anxiety by personality trait during early pregnancy: A longitudinal study of Japanese pregnant women Reviewed

Saho Maruya, Koji Tamakoshi, Masami Hirose, Yuki Takahashi, Akiko Yamada, Noriko Kato

Japan Journal of Nursing Science 2023.10

MEASURES OF LONG-TERM SYSTOLIC BLOOD PRESSURE VARIABILITY AND THEIR ASSOCIATIONS WITH THE RISK OF INCIDENT TYPE 2 DIABETES MELLITUS

Song, ZA; He, YP; Chiang, CF; Alshoaibi, AAA; Rahman, KMSU; Mamun, MR; Aoyama, A; Hirakawa, Y; Matsunaga, M; Ota, A; Tamakoshi, K; Li, YY; Yatsuya, H

JOURNAL OF HYPERTENSION Vol. 41 page： E134 - E134 2023.1

Association of pulse pressure with all-cause mortality in older Japanese patients with type 2 diabetes mellitus: A observational cohort study. Reviewed

Fukunaga N, Tamakoshi K, Hayashi T

Japan journal of nursing science : JJNS page： e12517 2022.10

Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study.

Matsunaga M, Yatsuya H, Iso H, Li Y, Yamagishi K, Tanabe N, Wada Y, Ota A, Tamakoshi K, Tamakoshi A

Journal of atherosclerosis and thrombosis Vol. 29 ( 10 ) page： 1547 - 1562 2022.10

Long-term variability and change trend of systolic blood pressure and risk of type 2 diabetes mellitus in middle-aged Japanese individuals: findings of the Aichi Workers' Cohort Study

Song Zean, He Yupeng, Chiang Chifa, Al-Shoaibi Abubakr A. A., Saif-Ur-Rahman K. M., Mamun Md Razib, Aoyama Atsuko, Hirakawa Yoshihisa, Matsunaga Masaaki, Ota Atsuhiko, Tamakoshi Koji, Li Yuanying, Yatsuya Hiroshi

HYPERTENSION RESEARCH 2022.8

Relationships Between Care Recipients' Psychological Symptoms and Family Caregivers' Depressive States

Hoshino Junko, Tamakoshi Koji, Hori Yoko, Sakakibara Hisataka

HOME HEALTH CARE MANAGEMENT AND PRACTICE Vol. 34 ( 3 ) page： 167 - 174 2022.8

Effectiveness of a new interactive web teaching material for improving lung auscultation skills: randomized controlled trial for clinical nurses.

Higashiyama S, Tamakoshi K, Yamauchi T

Nagoya journal of medical science Vol. 84 ( 3 ) page： 526 - 538 2022.8

Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting.

Al-Shoaibi AAA, Li Y, Song Z, Chiang C, Hirakawa Y, Saif-Ur-Rahman KM, Shimoda M, Nakano Y, Matsunaga M, Aoyama A, Tamakoshi K, Ota A, Yatsuya H

Journal of atherosclerosis and thrombosis 2022.7

Hospital organizational structure factors related to discharge planning activities for alcoholics by nurses in Japan

Adachi Madoka, Tamakoshi Koji, Watai Izumi

JAPAN JOURNAL OF NURSING SCIENCE Vol. 19 ( 3 ) page： e12473 2022.7

Increased afternoon step count increases heart rate variability in patients with cardiovascular risk factors

Nakayama Natsuki, Miyachi Masahiko, Tamakoshi Koji, Morikawa Shuji, Negi Koji, Watanabe Koji, Moriwaki Yoshimi, Hirai Makoto

JOURNAL OF CLINICAL NURSING Vol. 31 ( 11-12 ) page： 1636 - 1642 2022.6

Association between caregivers' health-related quality of life and care recipients' health outcomes

Hoshino Junko, Tamakoshi Koji, Hori Yoko, Sakakibara Hisataka

INTERNATIONAL JOURNAL OF NURSING PRACTICE Vol. 28 ( 3 ) page： e13044 2022.6

Evaluation of the risk factors for antepartum hemorrhage in cases of placenta previa: a retrospective cohort study

Kuribayashi Momoko, Tsuda Hiroyuki, Ito Yumiko, Tezuka Atsuko, Ando Tomoko, Tamakoshi Koji, Mizuno Kimio

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH Vol. 49 ( 11 ) page： 3000605211054706 2021.11

Decreased continuous sitting time increases heart rate variability in patients with cardiovascular risk factors

Nakayama Natsuki, Miyachi Masahiko, Tamakoshi Koji, Hayashi Toshio, Negi Koji, Watanabe Koji, Hirai Makoto

PLOS ONE Vol. 16 ( 6 ) page： e0253399 2021.6

Relationship between fasting blood glucose levels in middle age and cognitive function in later life: The Aichi Workers' Cohort Study.

Shimoda M, Kaneko K, Nakagawa T, Kawano N, Otsuka R, Ota A, Naito H, Matsunaga M, Ichino N, Yamada H, Chiang C, Hirakawa Y, Tamakoshi K, Aoyama A, Yatsuya H

Journal of epidemiology 2021.5

The Self of Adolescents with Autism Spectrum Disorder or Attention Deficit Hyperactivity Disorder: A Qualitative Study

Hanai Fumi, Narama Miho, Tamakoshi Koji

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS Vol. 51 ( 5 ) page： 1668 - 1677 2021.5

Structure and predictors of in-hospital nursing care leading to reduction in early readmission among patients with schizophrenia in Japan: A cross-sectional study.

Maki S, Nagai K, Ando S, Tamakoshi K

PloS one Vol. 16 ( 4 ) page： e0250771 2021

Positive Association of Physical Activity with Both Objective and Perceived Measures of the Neighborhood Environment among Older Adults: The Aichi Workers' Cohort Study

Li Yuanying, Yatsuya Hiroshi, Hanibuchi Tomoya, Ota Atsuhiko, Naito Hisao, Otsuka Rei, Murata Chiyoe, Hirakawa Yoshihisa, Chiang Chifa, Uemura Mayu, Tamakoshi Koji, Aoyama Atsuko

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH Vol. 17 ( 21 ) 2020.11

Risk and population attributable fraction of metabolic syndrome and impaired fasting glucose for the incidence of type 2 diabetes mellitus among middle-aged Japanese individuals: Aichi Worker's Cohort Study

Kaneko Kayo, Yatsuya Hiroshi, Li Yuanying, Uemura Mayu, Chiang Chifa, Hirakawa Yoshihisa, Ota Atsuhiko, Tamakoshi Koji, Aoyama Atsuko

JOURNAL OF DIABETES INVESTIGATION Vol. 11 ( 5 ) page： 1163 - 1169 2020.9

The effects of nausea, vomiting, and social support on health-related quality of life during early pregnancy: A prospective cohort study

Hirose Masami, Tamakoshi Koji, Takahashi Yuki, Mizuno Taeko, Yamada Akiko, Kato Noriko

JOURNAL OF PSYCHOSOMATIC RESEARCH Vol. 136 page： 110168 2020.9

Increased Activity in Patients with Cardiovascular Risk Factors Increases Heart Rate Variability

Nakayama Natsuki, Miyachi Masahiko, Tamakoshi Koji, Negi Koji, Watanabe Koji, Hirai Makoto

WESTERN JOURNAL OF NURSING RESEARCH Vol. 42 ( 6 ) page： 431 - 436 2020.6

The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study

Yamamoto Eiko, Tien Dat Minh, Sekiya Yoko, Tamakoshi Koji, Xuan Phuoc Nguyen, Nishino Kimihiro, Kotani Kaoru Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Quang Thanh Le, Kikkawa Fumitaka

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 82 ( 2 ) page： 183 - 191 2020.5

Relationship of household salt intake level with long-term all-cause and cardiovascular disease mortality in Japan: NIPPON DATA80

Shima Azusa, Miyamatsu Naomi, Miura Katsuyuki, Miyagawa Naoko, Okuda Nagako, Yoshita Katsushi, Kadota Aya, Suzuki Harumitsu, Kondo Keiko, Okamura Tomonori, Okayama Akira, Ueshima Hirotsugu, Saitoh Shigeyuki, Sakata Kiyomi, Hozawa Atsushi, Hayakawa Takehito, Nakamura Yosikazu, Nishi Nobuo, Ohkubo Takayoshi, Kasagi Fumiyoshi, Murakami Yoshitaka, Izumi Toru, Matsumura Yasuhiro, Ojima Toshiyuki, Tamakoshi Koji, Nakagawa Hideaki, Kita Yoshikuni, Fujiyoshi Akira, Nakamura Yasuyuki, Miyamoto Yoshihiro, Kodama Kazunori, Kiyohara Yutaka

HYPERTENSION RESEARCH Vol. 43 ( 2 ) page： 132 - 139 2020.2

Television Viewing Time and Breast Cancer Incidence or Japanese Premenopausal and Postmenopausal Women: The JACC Study

Cao Jinhong, Eshak Ehab Salah, Liu Keyang, Muraki Isar, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo, Kurozawa Yoichi

CANCER RESEARCH AND TREATMENT Vol. 51 ( 4 ) page： 1509 - 1517 2019.10

Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke: Findings From the Japan Collaborative Cohort Study

Ukawa Shigekazu, Zhao Wenjing, Yatsuya Hiroshi, Yamagishi Kazumasa, Tanabe Naohito, Iso Hiroyasu, Tamakoshi Akiko, Mori Mitsuru, Sakauchi Fumio, Motohashi Yutaka, Tsuji Ichiro, Nakamura Yosikazu, Iso Hiroyasu, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Miki Tsuneharu, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo

JOURNAL OF EPIDEMIOLOGY Vol. 29 ( 6 ) page： 233 - 237 2019.6

Cardiovascular Risk Assessment Chart by Dietary Factors in Japan - NIPPON DATA80-

Kondo Keiko, Miura Katsuyuki, Tanaka-Mizuno Sachiko, Kadota Aya, Arima Hisatomi, Okuda Nagako, Fujiyoshi Akira, Miyagawa Naoko, Yoshita Katsushi, Okamura Tomonori, Okayama Akira, Ueshima Hirotsugu, Ueshima Hirotsugu, Okayama Akira, Ueshima Hirotsugu, Okamura Tomonori, Saitoh Shigeyuki, Sakata Kiyomi, Hozawa Atsushi, Hayakawa Takehito, Nakamura Yosikazu, Nishi Nobuo, Okuda Nagako, Ohkubo Takayoshi, Kasagi Fumiyoshi, Murakami Yoshitaka, Izumi Toru, Matsumura Yasuhiro, Ojima Toshiyuki, Tamakoshi Koji, Nakagawa Hideaki, Kita Yoshikuni, Miura Katsuyuki, Kadota Aya, Fujiyoshi Akira, Miyamatsu Naomi, Nakamura Yasuyuki, Yoshita Katsushi, Miyamoto Yoshihiro, Kodama Kazunori, Kiyohara Yutaka

CIRCULATION JOURNAL Vol. 83 ( 6 ) page： 1254 - + 2019.6

Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly: NIPPON DATA 80, 90, and 2010

Shibata Yosuke, Ojima Toshiyuki, Nakamura Mieko, Kuwabara Kazuyo, Miyagawa Naoko, Saito Yoshino, Nakamura Yasuyuki, Kiyohara Yutaka, Nakagawa Hideaki, Fujiyoshi Akira, Kadota Aya, Ohkubo Takayoshi, Okamura Tomonori, Ueshima Hirotsugu, Okayama Akira, Miura Katsuyuki, Ueshima Hirotsugu, Miura Katsuyuki, Okayama Akira, Okamura Tomonori, Okayama Akira, Okamura Tomonori, Ueshima Hirotsugu, Okayama Akira, Okamura Tomonori, Saitoh Shigeyuki, Sakata Kiyomi, Hozawa Atsushi, Hayakawa Takehito, Nakamura Yosikazu, Nishi Nobuo, Okuda Nagako, Okamura Tomonori, Murakami Yoshitaka, Ohkubo Takayoshi, Kasagi Fumiyoshi, Izumi Toru, Matsumura Yasuhiro, Ojima Toshiyuki, Tamakoshi Koji, Nakagawa Hideaki, Kita Yoshikuni, Miura Katsuyuki, Kadota Aya, Miyamatsu Naomi, Nakamura Yasuyuki, Yoshita Katsushi, Miyamoto Yoshihiro, Kodama Kazunori, Kiyohara Yutaka

JOURNAL OF EPIDEMIOLOGY Vol. 29 ( 4 ) page： 133 - 138 2019.4

Sleep duration and risk of breast cancer: The JACC Study

Cao Jinhong, Eshak Ehab S., Liu Keyang, Muraki Isao, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo

BREAST CANCER RESEARCH AND TREATMENT Vol. 174 ( 1 ) page： 219-225 2019.2

Television viewing time, walking time, and risk of type 2 diabetes in Japanese men and women: The Japan Collaborative Cohort Study

Ikehara Satoyo, Iso Hiroyasu, Maruyama Koutatsu, Ukawa Shigekazu, Tamakoshi Akiko, Aoki Kunio, Ohno Yoshiyuki, Sugano Haruo, Tajima Kazao, Mori Mitsuru, Sakauchi Fumio, Motohashi Yutaka, Tsuji Ichiro, Nakamura Yoshikazu, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Miki Tsuneharu, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo

PREVENTIVE MEDICINE Vol. 118 page： 220-225 2019.1

Time-Related Changes in Relationships Between the Keys Score, Dietary Lipids, and Serum Total Cholesterol in Japan - NIPPON DATA80/90/2010-

Okami Yukiko, Ueshima Hirotsugu, Nakamura Yasuyuki, Kondo Keiko, Kadota Aya, Okuda Nagako, Okamura Tomonori, Miura Katsuyuki, Fujiyoshi Akira, Hozawa Atsushi, Kadota Aya, Kasagi Fumiyoshi, Nakagawa Hideaki, Toyoshima Hideaki, Yanagawa Hiroshi, Yoshita Katsushi, Kodama Kazunori, Ueda Kazuo, Sakata Kiyomi, Tamakoshi Koji, Okuda Nagako, Miyamatsu Naomi, Nishi Nobuo, Saitoh Shigeyuki, Tokudome Shinkan, Okubo Takayoshi, Hayakawa Takehito, Izumi Toru, Ojima Toshiyuki, Matsumura Yasuhiro, Miyamoto Yoshihiro, Kita Yoshikuni, Murakami Yoshitaka, Nakamura Yoshikazu, Kiyohara Yutaka

CIRCULATION JOURNAL Vol. 83 ( 1 ) page： 147-+ 2019.1

Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders

Matsukawa Satoshi, Sumigama Seiji, Kotani Tomomi, Wang Jingwen, Miki Rika, Moriyama Yoshinori, Nakano Tomoko, Mano Yukio, Tsuda Hiroyuki, Tamakoshi Koji, Kikkawa Fumitaka

GYNECOLOGIC AND OBSTETRIC INVESTIGATION Vol. 84 ( 4 ) page： 396 - 406 2019

Smoking results in accumulation of ectopic fat in the liver

Kato Ayako, Li Yuanying, Ota Atsuhiko, Naito Hisao, Yamada Hiroya, Nihashi Takashi, Hotta Yo, Chiang Chifa, Hirakawa Yoshihisa, Aoyama Atsuko, Tamakoshi Koji, Yatsuya Hiroshi

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY Vol. 12 page： 1075-1079 2019

Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study

Nishida Yoko, Kubota Yasuhiko, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Iso Hiroyasu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Ando Masahiko, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Fujino Yoshihisa, Shibata Akira

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS Vol. 26 ( 9 ) page： 775 - 782 2019

Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up.

2018.9

The association between objective measures of residence and worksite neighborhood environment, and self-reported leisure-time physical activities: The Aichi Workers' Cohort Study.

Li Y, Yatsuya H, Hanibuchi T, Hirakawa Y, Ota A, Uemura M, Chiang C, Otsuka R, Murata C, Tamakoshi K, Toyoshima H, Aoyama A

Preventive medicine reports Vol. 11 page： 282-289 2018.9

Relationship between the mode of conception and depressive symptoms during the first 6months post-partum in Japan

Mori Emi, Iwata Hiroko, Maehara Kunie, Sakajo Akiko, Tamakoshi Koji

REPRODUCTIVE MEDICINE AND BIOLOGY Vol. 17 ( 3 ) page： 275 - 282 2018.7

Course of maternal fatigue and its associated factors during the first 6 months postpartum: a prospective cohort study

Iwata Hiroko, Mori Emi, Sakajo Akiko, Aoki Kyoko, Maehara Kunie, Tamakoshi Koji

NURSING OPEN Vol. 5 ( 2 ) page： 186-196 2018.4

Shoulder stiffness, back pain, and wrist pain: Are older primiparas more vulnerable?

Iwata Hiroko, Mori Emi, Maehara Kunie, Sakajo Akiko, Aoki Kyoko, Tamakoshi Koji

INTERNATIONAL JOURNAL OF NURSING PRACTICE Vol. 24 page： e12654 2018.4

A Point System for Predicting 10-Year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study.

Yatsuya H, Li Y, Hirakawa Y, Ota A, Matsunaga M, Haregot HE, Chiang C, Zhang Y, Tamakoshi K, Toyoshima H, Aoyama A

Journal of epidemiology 2018.3

Association between the perspective of adult inpatients with digestive cancer regarding the nursing service and their quality of recovery on postoperative day 3

Sasaki Kumiko, Tamakoshi Koji

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 1 ) page： 29-37 2018.2

The Positive Association Between Duration of Skin-to-Skin Contact and Blood Glucose Level in Full-Term Infants.

Takahashi Y, Tamakoshi K

The Journal of perinatal & neonatal nursing Vol. 32 ( 4 ) page： 351 - 357 2018

[The relationship between parenting anxiety in mothers and the resources from which they routinely sought advice: The final "Healthy Parents and Children 21" survey].

Yamazaki S, Shinohara R, Akiyama Y, Ichikawa K, Ojima T, Tamakoshi K, Matsuura K, Yamazaki Y, Yamagata Z

[Nihon koshu eisei zasshi] Japanese journal of public health Vol. 65 ( 7 ) page： 334-346 2018

Obstetric factors associated with salivary cortisol levels of healthy full-term infants immediately after birth

Takahashi Y., Matsushima M., Nishida T., Tanabe K., Kawabe T., Tamakoshi K.

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY Vol. 45 ( 6 ) page： 828-832 2018

Association of serum asymmetric dimethylarginine, homocysteine, and l-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy. Reviewed

MURATE ei, WANG Jingwen, KOTANI Tomomi, TSUDA Hiroyuki, NAKANO Tomoko, IMAI Kenji, SUMIGAMA Seiji, NIWA Yoshimitsu, MITSUI Takashi, YOSHIDA Shigeru, YAMASHITA Mamoru, NAWA Akihiro, TAMAKOSHI Koji, KAJIYAMA Hiroaki, KIKKAWA Fumitaka

Clinica Chimica Acta Vol. 475 page： 70-77 2017.12

Anxiety during pregnancy and autonomic nervous system activity: A longitudinal observational and cross-sectional study. Reviewed

MIZUNO Taeko, TAMAKOSHI Koji, TANABE Keiko

J Psychosom Res Vol. 99 page： 105-111 2017.8

Palliative care and nursing support for patients experiencing dyspnoea. Reviewed

SUGIMURA Ayumi, ANDO Shoko, TAMAKOSHI Koji

Int J Palliat Nurs Vol. 23 ( 7 ) page： 342-351 2017.7

Association between physical and depressive symptoms during the first 6 months postpartum. Invited Reviewed

MORI Emi, IWATA Hiroko, SAKAJO Akiko, MAEAGARA Kunie, TAMAKOSHI Koji

Int J Nurs Pract Vol. 23 ( Suppl 1 ) 2017.6

Similarities and differences between coronary heart disease and stroke in the associations with cardiovascular risk factors: The Japan Collaborative Cohort Study. Reviewed

MATSUNAGA Masaaki, YATSUYA Hiroshi, ISO Hiroyasu, YAMASHITA Kentaro, LI Yuanying, YAMAGISHI Kaxumasa, TANABE Naohiro, WADA Yasuhiko, WANG Chaochen, OTA Atsuhiko, TAMAKOSHI Koji, TAMAKOSHI Akiko

Atherosclerosis Vol. 261 page： 124-130 2017.6

Association between physical and depressive symptoms during the first 6months postpartum

Mori Emi, Iwata Hiroko, Sakajo Akiko, Maehara Kunie, Tamakoshi Koji

INTERNATIONAL JOURNAL OF NURSING PRACTICE Vol. 23 2017.6

Similarities and differences between coronary heart disease and stroke in the associations with cardiovascular risk factors: The Japan Collaborative Cohort Study

Matsunaga Masaaki, Yatsuya Hiroshi, Iso Hiroyasu, Yamashita Kentaro, Li Yuanying, Yamagishi Kazumasa, Tanabe Naohito, Wada Yasuhiko, Wang Chaochen, Ota Atsuhiko, Tamakoshi Koji, Tamakoshi Akiko

ATHEROSCLEROSIS Vol. 261 page： 124-130 2017.6

Long-term weight-change slope, weight fluctuation and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: findings of Aichi Workers' Cohort Study. Reviewed

ZHANG Yan, YATSUYA Hiroshi, LI Yuanying, CHIANG Chifa, HIRAKAWA Yoshihisa, TAMAKOSHI Koji, TOYOSHIMA Hideaki, AOYAMA Atsuko

Nutr Diabetes Vol. 7 ( 3 ) page： e252 2017.3

The relationship between three signs of fetal magnetic resonance imaging and severity of congenital diaphragmatic hernia. Reviewed

HATTORI T, HAYAKAWA M, ITO M, SATO Y, TAMAKOSHI K, KANAMORI Y, OKUYAMA H, INAMURA N, TAKAHASHI S, FUJINO Y, TAGUCHI T, USUI N

J Perinatol Vol. 37 ( 3 ) page： 265-269 2017.3

Fatigue, depression, maternal confidence, and maternal satisfaction during the first month postpartum: A comparison of Japanese mothers by age and parity. Reviewed

MORI Emi, TSUCHIYA Miyako, MAEHARA Kunie, IWATA Hiroko, SAKAJO Akiko, TAMAKOSHI Koji

Int J Nurs Pract Vol. 23 ( 1 ) 2017.2

Perinatal outcomes of abnormal umbilical coiling according to a modified umbilical coiling index. Reviewed

OHNO Yauamasa, TERAUCHI Mikio, TAMAKOSHI Koji

J Obstet Gynaecol Res. Vol. 42 ( 11 ) page： 1457-1463 2016.11

Factors affecting maternal confidence among older and younger Japanese primiparae at one month post-partum. Reviewed

MAEHARA Kunie, MORI Emi, TSUCHIYA Miyako, IWATA Hiroko, SAKAJO Akiko, OZAWA Harumi, MORITA Akiko, MAEKAWA Tomoko, MAKAYA Miyuki, TAMAKOSHI Koji

Jpn J Nurs Sci Vol. 13 ( 4 ) page： 424-436 2016.10

Prevalence of postpartum depressive symptoms during the first 6 months postpartum: Association with maternal age and parity. Reviewed

IWATA Hiroko, MORI Emi, SAKAJO Akiko, AOKI Kyoko, MAEHARA Kunie, TAMAKOSHI Koji

J Affect Disord. Vol. 203 page： 227-232 2016.10

Perinatal outcomes of abnormal umbilical coiling according to a modified umbilical coiling index. Reviewed

OHNO Yasumasa, TERAUCHI Mikio, TAMAKOSHI Koji

J Obstet Gynaecol Res 2016.8

Caregiving activities closely associated with the development of low-back pain among female family caregivers. Reviewed

SUZUKI Kishiko, TAMAKOSHI Koji, SAKAKIBARA Hisataka

J Clin Nurs Vol. 25 ( 16-16 ) page： 2156-2167 2016.8

Comparison of prognoses according to non-positive and positive spectrin αII expression detected immunohistochemically in epithelial ovarian carcinoma: a retrospective study. Reviewed

MAEDA Osamu, MIYATA-TAKATA Tomoko, SHIBATA Kiyosumi, KAJIYAMA Hiroaki, MIZUNO Mika, TAMAKOSHI Koji, SHIMOYAMA Yoshie, NAKAMURA Shigeo, KIKKAWA Fumitaka

Cancer Med Vol. 5 ( 6 ) page： 1081-1092 2016.6

Prospective study of seaweed consumption and thyroid cancer incidence in women: the Japan collaborative cohort study. Reviewed

WANG Chaochen, YATSUYA Hiroshi, LI Yuanying, OTA Atsuhiko,TAMAKOSHI Koji, FUJINO Yoshihisa, MIKAMI Haruo, ISO Hiroyasu, TAMAKOSHI Akiko

Eur J Cancer Prev Vol. 25 ( 3 ) page： 239-245 2016.5

Factors affecting maternal confidence and satisfaction in older Japanese primiparae during postpartum hospital stay. Reviewed

MAEHARA Kunie, MORI Emi, TSUCHIYA Miyako, IWATA Hiroko, SAKAJO Akiko, TAMAKOSHI Koji

Int J Nurs Prac Vol. 22 ( Suppl 1 ) page： 14-21 2016.4

Cross-sectional and longitudinal validation of a 13-item fatigue scale among Japanese postpartum mothers. Reviewed

Tsuchiya M, Mori E, Sakajo A, Iwata H, Maehara K, Tamakoshi K.

Int J Nurs Pract Vol. 22 ( Suppl 1 ) page： 5-13 2016.4

The risk factors for labor onset hypertension Reviewed

OHONO Yasumasa, TERAUCHI Mikio, TAMAKOSHI Koji, SHIOZAKI Arihiro, SAITO Shigeru

Hypertens Res Vol. 39 ( 4 ) page： 260-265 2016.4

Impact of chorioamnionitis on short- and long-term outcomes in very low birth weight preterm infants: the Neonatal Research Network Japan. Reviewed

MIYAZAKI Ken, FURUHASHI Madoka, ISHIAKAWA Kaoru, TAMAKOSHI Koji, HAYASHI Kazutoshi, KAI Akihiro, ISHIKAWA Hiroshi, MURABAYASHI Nao, KEDA Tomoaki, KONO Yumi, KUSADA Satoshi, FUJIMURA Masanori

J Matern Fetal Neonatal Med. Vol. 29 ( 2 ) page： 331-337 2016.2

Age-specific determinants of post-partum fatigue in primiparous women. Reviewed

TSUCHIYA Miyako, MORI Emi,, SAKAJO Akiko,MAEKAWA Tomoko, IWATA Hiroko, MAEHARA Kunie, MORITA Akiko, OZAWA Harumi, MOCHUZUKI Yoshimi, AOKI Kyoko, MAKAYA Miyuki, TAMAKOSHI Koji

Jpn J Nurs Sci Vol. 13 ( 1 ) page： 93-94 2016.1

Predictors of depressive symptoms in older Japanese primiparas at 1 month post-partum: A risk-stratified analysis. Reviewed

IWATA Hiroko, MORI Emi, TSUCHIYA Miyako, SAKAJO Akiko, MAEHARA Kunie, OZAWA Harumi, MORITA Akiko, MAEKAWA Tomoko, AOKI Kyoko, TAMAKOSHI Koji

Jpn J Nurs Sci Vol. 13 ( 1 ) page： 147-155 2016.1

Weight Gain and Alcohol Drinking Associations with Breast Cancer Risk in Japanese Postmenopausal Women - Results from the Japan Collaborative Cohort (JACC) Study. Reviewed

NITTA Junichi, NOJIMA Masanori, OHNISHI Hirofumi, MORI Mitsuru, WAKAI Kenji, SUZUKI Sadao, FUJINO Yoshihisa, LIN Yingsong, TAMAKOSHI Koji, TAMAKOSHI Akiko

Asian Pac J Cancer Prev Vol. 17 ( 3 ) page： 1437-1443 2016

Long-term outcomes of antenatal corticosteroids treatment in very preterm infants after chorioamnionitis. Reviewed

MIYAZAKI Ken, FURUHASHI Madoka, ISHIAKAWA Kaoru, TAMAKOSHI Koji, HAYASHI Kazutoshi, KAI Akihiro, ISHIKAWA Hiroshi, MURABAYASHI Nao, KEDA Tomoaki, KONO Yumi, KUSADA Satoshi, FUJIMURA Masanori

Arch Gynecol Obstet Vol. 292 ( 6 ) page： 1239-1246 2015.12

Predicting early post-partum depressive symptoms among older primiparous Japanese mothers. Reviewed

IWATA Hiroko, MORI Emi, TSUCHIYA Miyako, SAKAJO Akiko, MAEHARA Kunie, OZAWA Harumi, MORITA Akiko, MAEKAWA Tomoko, AOKI Kyoko, MAKAYA Miyuki, TAMAKOSHI Koji

Japanese Journal of Nursing Science Vol. 12 ( 4 ) page： 297-308 2015.10

Association between parental history of diabetes and the incidence of type 2 diabetes mellitus differs according to the sex of the parent and offspring's body weight: A finding from a Japanese worksite-based cohort study. Reviewed

WANG Chaochen, YATSUYA Hiroshi, TAMAKOSHI Koji, TOYOSHIMAHideaki, WADA Keiko, LI Yuanying, HILAWE Esayas Haregot, UEMURA Mayu, CHIANG Chifa, ZHANG Yan, OTSUKA Rei, OTA Atsuhiko, HIRAKAWA Yoshihisa, AOYAMA Atsuko

Prev Med. 2015.8

Breakfast Skipping is Positively Associated With Incidence of Type 2 Diabetes Mellitus: Evidence From the Aichi Workers' Cohort Study. Reviewed

UEMURA Mayu, YATSUYA Hiroshi, HILAWEI Esayas Haregot, LI Yuanying, WANG Chaochen, CHIANG Chifa, OTSUKA Rei, TOYOSHIMA Hideaki, TAMAKOSHI Koji, AOYAMA Atsuko

J Epidemiol. Vol. 25 ( 5 ) page： 351-358 2015.5

Smoking and diabetes: is the association mediated by adiponectin, leptin, or C-reactive protein? Reviewed

HILAWE Esayas Haregot, Hiroshi Yatsuya, Yuanying Li, UEMURA Mayu, WANG Chaochen, CHIANG Chifa, TOYOSHIMA Hideaki, TAMAKOSHI Koji, ZHANG Yan, KAWAZOE Nobuo, AOYAMA Atsuko

J Epidemiol Vol. 25 ( 2 ) page： 99-109 2015.2

Milk drinking and mortality: findings from the Japan collaborative cohort study. Reviewed

WANG Chaochen, YATSUYA Hiroshi, TAMAKOSHI Koji, ISO Hiroyasu, TAMAKOSHI Akiko

J Epidemiol Vol. 25 ( 1 ) page： 66-73 2015.1

Is the serum l-arginine level during early pregnancy a predictor of pregnancy-induced hypertension? Reviewed

WANG Jingwen, KOTANI Tomomi, TSUDA Hiroyuki, MANO Yukio, SUMIGAMA Seiji, LI Hua, KOMATSU Koji, MIKI Rika, MARUTA Ei, NIWA Yoshimitsu, MITSUI Takashi, YOSHIDA Shigeru, TAMASHITA Mamoru, TAMAKOSHI Koji, KIKKAWA Fumitaka

J Clin Biochem Nutr. Vol. 57 ( 1 ) page： 74-81 2015.1

Independent association of liver fat accumulation with insulin resistance. Reviewed

YATSUYA Hiroshi, NIHASHI Takashi, LI Yuanying, HOTTA You, MATSUSHITA Kunihiro, MURAMATSU Takashi, OTSUKA Rei, MATSUNAGA Masaaki, YAMASHITA Kentaro, WANG Chaochen, UEMURA Mayu, HARADA Akiko, FAKATSU Hiroshi, TOYOSHIMA Hideaki, AOYAMA Atsuko, TAMAKOSHI Koji

Obes Res Clin Pract Vol. 8 ( 4 ) page： 350-355 2014.7

The effects of antenatal corticosteroids therapy on very preterm infants after chorioamnionitis. Reviewed

MIYAZAKI Ken, FURUHASHI Madoka, ISHIAKAWA Kaoru, TAMAKOSHI Koji, IKEDA Tomoaki

Arch Gynecol Obstet Vol. 286 ( 6 ) page： 1185-1190 2014.7

The levels of the neutrophil elastase in the amniotic fluid of pregnant women whose infants develop bronchopulmonary dysplasia.

IKEDA Sayako, KIHIRA Kana, TOKOI Akira, TAMAKOSHI Koji, MIYAZAKI Ken, FURUHASGI Madoka

J Matern Fatal Neonatal Med page： 1-5 2014.6

Uterine sutures at prior caesarean section and placenta accreta in subsequent pregnancy: a case-control study. Reviewed

SUMIGAMA Seiji, SUGIYAMA Chisato, KOTANI Tomomi, HAYAKAWA Hiromi, INOUE AKIKO, MANO Yukio, TSUDA Hiroyuki, FURUHASHI Madoka, YAMAMURO Osamu, KINOSHIATA Yoshito, OKAMOTO Tomomitsu, NAKAMURA Hiromi, MATSUSAWA Katsuji, SAKAKIBARA Katsumi, OGUCHI Hidenori, KAWAi Michiyasu, SHIMOYAMA Yoshie, TAMAKOSHI Koji, KIKKAWA Fumitaka

British Journal of Obstetrics and Gynaecology Vol. 121 ( 7 ) page： 866-74 2014.6

Descriptive epidemiological study of food intake among Japanese adults: analyses by age, time and birth cohort model. Reviewed

OTSUKA Rei, YATSUYA Hiroshi, TAMAKOSHI Koji

BMI Public Health Vol. 14 page： 328 2014.4

Body mass index-modified relationship of chronic mental stress with resting blood pressure during 5 years in Japanese middle-aged male workers. Reviewed

TOYOSHIMA hideaki, OTSUKA Rei, HASHIMOTO Shuji, RAMAKOSHI Koji, YATSUYA Hiroshi

Circulation Journal Vol. 78 ( 6 ) page： 1379-1386 2014.4

Factors associated with early postpartum maternity blues and depression tendency among Japanese mothers with full-term healthy infants. Reviewed

TAKAHASHI Yuki, TAMAKOSHI Koji

Nagoya J Med Sci Vol. 76 ( 1-2 ) page： 129-138 2014.2

Learning disability in 10- to 16-year-old adolescents with very low birth weight in Japan. Reviewed

TANABE Keiko, TAMAKOSHI Koji, KIKUCHI Saya, MUROTSUKI Jun

Tohoku J Exp Med. Vol. 232 ( 1 ) page： 27-33 2014.1

Positive association between high-sensitivity C-reactive protein and incidence of type 2 diabetes mellitus in Japanese workers: 6-year follow-up Reviewed

WANG Chaochen, YATSUYA Hiroshi, TAMAKOSHI Koji, UEMURA Mayu, LI Yuanying, WADA Keiko, YAMASHITA Kentaro, KAWAGUCHU Leo, TOYOSHIMA Hideaki, AOYAMA Atsuko

Diabetes Metab Res Rev Vol. 29 ( 5 ) page： 398-405 2013.7

Ovarian cancer mortality among women aged 40-79 years in relation to reproductive factors and body mass index: latest evidence from the Japan Collaborative Cohort study Reviewed

KHAN Md. Mobarak Hossain, KHAN Aklimunnessa, NOJIMA Masahiro, SUZUKI Sadao, FUJINO Yoshihisa, TOKUDOME Shinkan, TAMAKOSHI Koji, MORI Mitsuru, TAMAKOSHI Akiko

J Gynecol Oncol Vol. 24 ( 3 ) page： 249-257 2013.7

Obesity/weight gain and breast cancer risk: findings from the Japan collaborative cohort study for the evaluation of cancer risk. Reviewed

SUZUKI Sadao, KOJIMA Masayo, TOKUDOME Shinkan, MORI Mitsuru, SAKAUCHI Fumio, WAKAI Kenji, FUJINO Yoshihisa, LIN Yingsong, KIKUCHI Shogo, TAMAKOSHI Koji, TAMAKOSHI Akiko

J Epidemiol Vol. 23 ( 2 ) page： 139-145 2013.2

Associations of protein, fat, and carbohydrate intakes with insomnia symptoms among middle-aged Japanese workers. Reviewed

TANAKA Eizaburo, YATSUYA Hiroshi, UEMURA Mayu, OTSUKA Rei, TOYOSHIMA Hideaki, TAMAKOSHI Koji, SASAKI Satoshi, KAWAGUCHI Leo, AOYAMA Atsuko

J Epidemiol Vol. 23 ( 2 ) page： 132-138 2013.2

Multiple roles and all-cause mortality: the Japan Collaborative Cohort Study Reviewed

TAMAKOSHI Akiko, IKEDA Ai, FUJINO Yoshihisa, TAMAKOSHI Koji, ISO Hiroyasu

Eur J Public Health 2013.2

Characteristics of hypertension-related factors in female home caregivers in Japan-comparison with general community non-caregivers. Reviewed

HOSHINO Junko, HORI Yoko, KONDO Takaaki, TAMAKOSHI Koji, TOYOSHIMA Hideaki, SAKAKIBARA Hisataka

J Clin Nurs 2013.2

Validation of the prediction model for success of vaginal birth after cesarean delivery in Japanese women. Reviewed

YOKOI Akira, ISHIKAWA Kaoru, MIYAZAKI Ken, TOSHIDA Kana, FYRUHASHI Madoka, TAMAKOSHI Koji

Int J Med Sci Vol. 9 ( 6 ) page： 488-491 2012.8

Inverse relationship of serum adiponectin concentration with type 2 diabetes mellitus incidence in middle-aged Japanese workers: six-year follow-up. Reviewed

LI Yuanying, YATSUYA Hiroshi, ISO Hiroyasu, TOYOSHIMA Hideaki, TAMAKOSHI Koji

Diabetes Metab Res Rev Vol. 28 ( 4 ) page： 349-356 2012.5

Multiple roles and all-cause mortality: the Japan Collaborative Cohort Study. Reviewed

TAMAKOSHI Akiko, IKEDA Ai, FUJINO Yoshihisa, TAMAKOSHI Koji, ISO Hiroyasu

Eur J Public Health 2012.1

Inverse relationship of serum adiponectin concentration with type 2 diabetes mellitus incidence in middle-aged Japanese workers: 6-year follow-up Reviewed

LI Yuanying, HATSUYA Hiroshi, ISO Hiroyasu, TOYOSHIMA Hideaki, TAMAKOSHI Koji

Diabetes Metab Res Rev 2012.1

Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma Reviewed

MAEDA Osamu, SHIBATA Kiyosumi, HOSONO Satoyo, FUJIWARA Sawako, KAJIYAMA Hiroaki, INO Kazuhiko, NAWA Akihiro, TAMAKOSHI Koji, KIKKAWA Fumitaka

Int J Cancer page： 113 - 121 2012.1

Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma Reviewed

MAEDA Osamu, SHIBATA Kiyosumi, HOSONO Satoyo, FUJIWARA Sawako, KAJIYAMA Hiroaki, INO Kazuhiko, NAWA Akihiro, TAMAKOSHI Koji, KIKKAWA Fumitaka

Int J Cancer Vol. 130 ( 1 ) page： 113-121 2012.1

Language：English Publishing type：Research paper (scientific journal)

PMID:21328338
To overcome drug resistance in ovarian carcinoma, novel resistance mechanisms must be elucidated for clinical application. We purified 2 proteins in the 300 kDa range from cisplatin-resistant cells (NOS2CR2) by affinity chromatography with cisplatin-exposed Glutathione Sepharose 4B. The purified proteins were identified as spectrin αII and βII by peptide mass mapping analysis. Western blot analysis detected greater expression of spectrin αII and βII in NOS2CR2 than in wild-type cells (NOS2). The same result was obtained for spectrin βII expression by immunohistochemical staining. To determine whether spectrin αII and βII contribute to resistance, a drug sensitivity test was performed on SKOV3 ovarian cancer cells transfected with small interfering RNA. Sensitivity to platinum drugs was increased in the expression reduced cells. In a clinical study of five ovarian serous adenocarcinoma cases, tumor specimens taken after treatment with carboplatin stained more strongly for spectrin βII expression than untreated specimens. Fifty-two tumor specimens from 46 patients with ovarian serous adenocarcinoma were immunohistochemically stained for spectrin βII and scored. Tumors previously treated by chemotherapy scored higher than those not treated. Of 27 cases with detectable residual tumors at the time of surgery, cases scoring 4-6 had shorter progression-free survival periods after platinum-based chemotherapy than cases scoring 0-3 (p = 0.012). The cytoskeleton proteins Spectrin αII and βII contributed to drug resistance by anchoring the GS-Pt complex to the cell membrane, arresting cisplatin activity. Thus spectrin βII may be a useful predictor of platinum sensitivity in ovarian serous adenocarcinoma.

DOI： 10.1002/ijc.25983

Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan. Reviewed

MURO Yoshinao, SUGIURA Kazumitsu, HOSHINO Kei, AKIYAMA Masashi, TAMAKOSHI Koji

Arthritis Res Ther Vol. 13 ( 6 ) page： 214 2011.12

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Several reports have found the onset or activity of inflammatory myopathies to show spatial clustering and seasonal association. We recently detected autoantibodies against melanoma differentiation-associated gene 5 (MDA-5) in more than 20% of patients with dermatomyositis. Anti-MDA-5 antibodies were associated with the presence of rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis (CADM). The present study aims to assess the growing prevalence of CADM and the geographical incidence of anti-MDA-5-positive patients.

METHODS: We reviewed medical charts and examined the presence of anti-MDA-5 antibodies in 95 patients, including 36 CADM patients. Sera were obtained from 1994 through 2011. Statistical analyses were performed to assess whether CADM development and the presence of anti-MDA-5 antibodies were associated with various parameters, including age at disease onset, season of onset, annual positivity, and population of resident city.

RESULTS: Tertiles based on the year when the sera were collected showed increasing tendencies of CADM and anti-MDA-5-positive patients among all of the dermatomyositis patients. From 1994 to 2010, the relative prevalence of CADM and anti-MDA-5 antibody-positive patients significantly increased. Interestingly, the presence of anti-MDA-5 antibodies in 26 patients was inversely associated with the population of their city of residence.

CONCLUSIONS: This is the first study to examine the distribution of anti-MDA-5-positive dermatomyositis phenotypes in Japan. Regional differences in the incidences of these phenotypes would suggest that environmental factors contribute to the production of antibodies against MDA-5, which triggers innate antiviral responses.

Number of children and all-cause mortality risk: results from the Japan Collaborative Cohort Study Reviewed

TAMAKOSHI Akiko, TAMAKOSHI Koji, LIN Yingsong, MIKAMI Haruo, INABA Yutaka, YAGYU Kiyoko, KIKUCHI Syogo; for the JACC Study Group.

Number of children and all-cause mortality risk: results from the Japan Collaborative Cohort Study page： 732 - 737 2011.12

女性における家族介護者の高血圧自覚の有無による血圧管理状況 Reviewed

鈴木洋子, 堀容子, 星野純子, 濱本律子, 杉山晃子, 岡田武, 永井邦芳, 近藤高明, 玉腰浩司, 岡本和士, 長澤伸江, 豊嶋英明, 榊原久孝

日本公衆衛生雑誌 Vol. 58 ( 12 ) page： 1016-1025 2011.12

Early age at menarche associated with increased all-cause mortality Reviewed

TAMAKOSHI Koji, HATSUYA Hiroshi, TAMAKOSHI Akiko

Eur J Epidemiol 2011.10

Maternal mental disorders and pregnancy outcomes: A clinical study in a Japanese population Reviewed

HIRONAKA Masae, KOTANI Tomomi, SUMIGAMA Seiji, TSUDA Hiroyuki, MANO Yukio, HAYAKAWA Hiromi, TANAKA Satoshi , OZAKI Norio, TAMAKOSHI Koji, KIKKAWA Fumitaka

J Obstet Gynaecol Res Vol. 37 ( 10 ) page： 1283-1289 2011.10

Comparison of salivary cortisol, heart rate, and oxygen saturation between early skin-to-skin contact with different initiation and duration times in healthy, full-term infants Reviewed

TAKAHASHI Yuki, TAMAKOSHI Koji, MATSUSHIMA Miyoko, KAWABE Tsutomu

Early Hum Dev Vol. 87 ( 3 ) page： 151-157 2011.3

Language：English Publishing type：Research paper (scientific journal)

PMID:21220191
BACKGROUND: There are few studies that compare the physiological and biological efficacies between different early skin-to-skin contacts (SSC) post birth.

AIM: To investigate physiologically and biochemically how early SSC with different initiation and duration time influence the stress post birth for full-term infants.

STUDY DESIGN: Non-experimental study.

SUBJECTS: Study I; Thirty-two infants who began SSC 5min or less [birth SSC, mean initiation time (standard deviation): 1.6 (1.1) min] after birth and 36 infants who did so more than 5min [very early SSC, 26.3 (5.0) min] in heart rate (HR) and oxygen saturation (SpO(2)) analysis. Study II; Eighteen infants who underwent SSC for 60min or less [mean initiation time: 7.5 (12.2) min] and 61 infants who did so for more than 60min [15.3 (12.5) min] in salivary cortisol analysis.

OUTCOME MEASURES: HR and SpO(2) measured for 30min post birth. Salivary cortisol concentration measured at 1min, 60min, and 120min post birth.

RESULTS: Birth SSC group reached HR stability of 120-160bpm significantly faster than very early SSC group by Kaplan-Meier analysis (P=0.001 by log-rank test). As for SpO(2) stability of 92% and 96%, no significantly between-group difference was found. Salivary cortisol levels were significantly lower between 60 and 120min after birth in SSC group, continuing for more than 60min compared with SSC group for 60min or less after adjustment for salivary cortisol level at 1min besides the infant stress factors (P=0.046).

CONCLUSIONS: Earlier SSC beginning within 5min post birth and longer SSC continuing for more than 60min within 120min post birth are beneficial for stability of cardiopulmonary dynamics and the reduction of infant stress during the early period post birth.

母娘二世代の母子健康手帳にみられる妊娠分娩経過の関連 Reviewed

田辺圭子，玉腰浩司，室月淳

母性衛生 Vol. 51 ( 4 ) page： 594-600 2011.1

Language：Japanese Publishing type：Research paper (scientific journal)

近年、成人病胎児期起源仮説、Developmental Origin of Health and Disease(DOHaD)仮説が注目されている。今回、母娘二世代362組の母子健康手帳を用いて、二世代間の妊娠分娩経過の関連を検討した。世代間比較では、二世代目は一世代目に比べ身長が高く、妊娠中の平均収縮期血圧が低く、体重増加量が少なく、出生した児の体重が軽かった。また、分娩時出血量が多く、分娩様式では帝王切開を受けた人が多かった。一方、二世代間の非妊娠時体格、妊娠中期以降の血圧や体重増加量、出生児の出生体重と頭囲は統計学的に有意な正の関連を示した。また、重回帰分析による三世代目の出生体重に関連する因子の分析では、二世代目の出生体重が二世代目の非妊娠時のBMIや妊娠時の体重増加量より強く関連することが示された。本研究の結果により、世代間の妊娠分娩経過には、社会背景の変化や医療水準の向上などによる差異はあるものの、関連がみられた。また、前世代の胎内環境が次世代の胎内環境に影響を与えることが示唆された。以上より、前世代の妊娠分娩経過を知ることは、妊娠早期からの保健指導を可能にし、妊娠中の合併症の予防、さらにはその先に続いてゆく世代の健康につながっていく可能性が示唆された。

Association of women's birth weight with their blood pressure during pregnancy and with the body size of their babies Reviewed

TANABE Keiko, TAMAKOSHI Koji, MUROTSUKI Jun

Tohoku J Exp Med Vol. 224 ( 4 ) page： 287-292 2011

Language：English Publishing type：Research paper (scientific journal)

PMID:21791889
The women's own intrauterine environment may influence their own pregnancy and their babies. The aim of our study was to investigate how a woman's birth weight affects the course of her pregnancy later in life as well as the body size of her babies; this study was based on the developmental origins of health and disease (DOHaD) concept. We collected Maternal and Child Health handbooks from 414 women and their biological mothers. They were classified into 3 categories based on the Fetal growth curve of Japan: light-for-date (LFD), which means birth weight is less than the -1.5SD; appropriate-for-date (AFD), which means it lies between the -1.5SD and +1.5SD; and heavy-for-date (HFD), which means it is in the +1.5SD, or higher. In the first trimester, systolic blood pressures (SBPs) were 117.6 (14.4 mmHg), 111.6 (12.4 mmHg), and 105.0 (11.6 mmHg), and diastolic blood pressures (DBP) were 71.0 (8.5 mmHg), 65.7 (9.4 mmHg), and 62.1 (8.7 mmHg) in women born LFD, AFD, and HFD, respectively (SBP: p for trend = 0.018, DBP: p for trend = 0.027). In the second and third trimesters, both SBP and DBP were higher for women born LFD than for those of the other 2 groups. Birth weights of the babies of women born LFD, AFD, and HFD were 2,791.1 (483.0 g), 3,043.4 (361.0 g), and 3,248.0 (431.5 g), respectively (p for trend < 0.01). Our findings support the DOHaD concept and suggest that intrauterine environment in fetal life may be passed down from generation to generation.

Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies. Reviewed

GKRANIA-KLOTSA Effrossyni, YE Zheng, COOPER Andrew J, SHARP Stephen J, LUBEN Robert, BIGGS Mary L, CHEN Liang-Kung, GOKULAKTISHNAN Kuppan, HANEFELD Markolf, INGELSSON Erik, LAI Wen-An, LIN Shih-Yi, LIND Lars, LOHSOONTHORN Vitool, MOHAN Viswanathan, MUSCARI Antonio, NILSSON Goran, OHRVIK John, CHAO QOANG Jiang, LENNY Nancy Swords, TAMAKOSHI Koji, TEMELKOVA-KURKTSCHIEV Theodora, WANG Ya-Yu, YAJNIK Chittaranjan Sakerlal, ZOLI Marco, KHAW Kay-Tee, FOROUHI Nita G, WAREHAM Nicholas J, LANGENBERG Claudia.

PLoS One Vol. 18 ( 5 ) page： 1-11 2010.10

Impact of smoking and other lifestyle factors on life expectancy among japanese: findings from the Japan Collaborative Cohort (JACC) Study. Reviewed

TAMAKOSHI Akiko, KAWADO Miyuki, OZASA Kotaro, TAMAKOSHI Koji, LIN Yingsong, YAGYU Kiyoko, KIKUCHI Syogo, HASHIMOTO Suji; JACC Study Group.

J Epidemiol Vol. 20 ( 5 ) page： 370376 2010.9

Language：English Publishing type：Research paper (scientific journal)

PMID: 20631456
BACKGROUND: A number of lifestyle factors, including smoking and drinking, are known to be independently associated with all-cause mortality. However, it might be more effective in motivating the public to adopt a healthier lifestyle if the combined effect of several lifestyle factors on all-cause mortality could be demonstrated in a straightforward manner.

METHODS: We examined the combined effects of 6 healthy lifestyle behaviors on all-cause mortality by estimating life expectancies at 40 and 60 years of age among 62 106 participants in a prospective cohort study with a 14.5-year follow-up. The healthy behaviors selected were current nonsmoking, not heavily drinking, walking 1 hour or more per day, sleeping 6.5 to 7.4 hours per day, eating green leafy vegetables almost daily, and having a BMI between 18.5 to 24.9.

RESULTS: At age 40, we found a 10.3-year increase in life expectancy for men and a 8.3-year increase for women who had all 6 healthy behaviors, as compared with those who had only 0 to 2 healthy behaviors. Increases of 9.6 and 8.2 years were observed for men and women, respectively, at age 60 with all 6 healthy behaviors. When comparing currently nonsmoking individuals with 0 to 1 healthy behaviors, the life expectancy of smokers was shorter in both men and women, even if they maintained all 5 other healthy behaviors.

CONCLUSIONS: Among individuals aged 40 and 60 years, maintaining all 6 healthy lifestyle factors was associated with longer life expectancy. Smokers should be encouraged to quit smoking first and then to maintain or adopt the other 5 lifestyle factors.

Body mass index and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanese cohorts using individual data. Reviewed

YATSUYA Hiroshi, TOYOSHIMA Hideaki, YAMAHISHI Kazymasa, TAMAKOSHI Koji, TAGURI Masataka, HARADA Akiko, OHHASHI Yasuo, KITA Yoshikuni, NAITO Yoshihiko, YAMADA Michiko, TANABE Naohito, ISO Hiroyasu, UESHIMA Hirotsugu; Japan Arteriosclerosis Longitudinal Study (JALS) group.

Circ Cardiovasc Qual Outcomes Vol. 3 ( 5 ) page： 498-505 2010.9

Incidence of metabolic syndrome according to combinations of lifestyle factors among middle-aged Japanese male workers. Reviewed

LI Yuanying, YATSUYA Hiroshi, ISO Hiroyasu, TAMAKOSHI Koji, TOYOSHIMA Hideaki.

Prev Med Vol. 51 ( 2 ) page： 118-122 2010.8

Language：English Publishing type：Research paper (scientific journal)

PMID: 20451548
OBJECTIVE: To examine a combination of healthy lifestyles on the risk of metabolic syndrome (MetS) to inform future interventions.

METHODS: A total of 1897 men aged 35-60 years participated in an annual health check-up in 2002 and 2005. MetS was defined by AHA/NCEP criteria. Logistic regression analyses were used to estimate age- and BMI-adjusted odds ratios (ORs) of MetS incidence for each healthy lifestyle (regular physical activity, adherence to healthy eating behaviors, not current smoking, and maintaining a stable weight since one's mid-twenties), separately (Model 1) and simultaneously (Model 2). A points system was developed to derive 3-year risk of MetS incidence by assigning a specific point to each healthy lifestyle.

RESULTS: MetS developed in 285 (15.0%) subjects after the follow-up. The ORs of MetS for each healthy lifestyle ranged from 0.42 to 0.64 (Model 2). Three-year risk of MetS incidence was predicted to differ from 1% to 60% according to the individual point total of the points system. The population-attributable fraction of MetS in subjects whose point total was not in the highest quartile was 71%.

CONCLUSION: Adherence to healthy lifestyles was associated with a lower risk of MetS among apparently healthy middle-aged Japanese male workers.

Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. Reviewed

MURAMATSU Takashi, YATSUYA Hiroshi, TOYOSHIMA Hideaki, SASAKI Satoshi, LI Yuanying, OTSUKA Rei, WADA Keiko, HOTTA Yo, MITSUHASHI Hirotsugu, MATSUSHITA Kunihiro, MUROHARA Toyoaki, TAMAKOSHI Koji.

Prev Med Vol. 50 ( 5-6 ) page： 272-276 2010.5

Language：English Publishing type：Research paper (scientific journal)

PMID: 20211645
OBJECTIVE: To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA+DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake.

METHOD: We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA+DHA intake as the reference were calculated by logistic regression analysis.

RESULTS: Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA+DHA were 47.9 years, 22.9 kg/m(2), and 1.90 g/day (0.88%E) and 0.77 g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1=0.74, P for trend=0.01) and the association was observed only in subjects with a BMI of <25 kg/m(2) (P for interaction=0.033). However EPA+DHA showed no such associations consistently.

CONCLUSION: Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women.

Iron intake and associated factors in general Japanese population: NIPPON DATA80, NIPPON DATA90 and national nutrition monitoring. Reviewed

YURIN Tanvir Chowdhury, OKUDA Nagako, MIURA Katsuyuki, NAKAMURA Yasuyuki, RUMADA Nahid, KADOTA Aya, TAMAKOSHI Koji, UESHIMA Hirotsugu; NIPPON DATA80/90 Research Group.

J Epidemiol Vol. Suppl 3 page： 557-566 2010.4

Language：English Publishing type：Research paper (scientific journal)

PMID: 20351478
OBJECTIVE: The purpose of this study was to investigate the dietary iron intake and associated other dietary factors and clinical characteristics among a representative sample cohort of Japanese population.

METHODS: We obtained data from NIPPON DATA80 and 90 that were conducted with the National Nutrition Surveys in 1980 and in 1990. Then we estimated nutrient and food intakes of individuals in the National Nutrition Survey of 1980 and that of 1990, which were adjusted on the basis of data of the National Nutrition Survey of 1995. Finally, we analyzed data for the 10,422 participants (4585 men and 5837 women) in NIPPON DATA80 and 8342 participants (3488 men and 4854 women) in NIPPON DATA90 having dietary iron intake information.

RESULTS: In NIPPON DATA80 and 90, there was a significant relationship between the dietary iron intake and age for both men and women. Dietary protein intake was associated with iron intake where as dietary fat intake did not show any association. Regarding the minerals, significant relationships were observed between the different minerals and dietary iron intake. Apart from the food group of milk and dairy products, there were significant differences in other food groups according to quintiles of iron intakes for men and women.

CONCLUSIONS: We described the mean dietary iron intake and its relation with other dietary factors and clinical characteristics in Japanese adults as the baseline data in NIPPON DATA80 and in NIPPON DATA90.

BMI and all-cause mortality among Japanese older adults: findings from the Japan collaborative cohort study. Reviewed

TAMAKOSHI Akiko, YATSUYA Hiroshi, LIN Yingsong, TAMAKOSHI Koji, KONDO Takaaki, SUZUKI Sadao, YAGYU Kiyoko, KIKUCHI Syogo; JACC Study Group.

Obesity (Silver Spring) Vol. 18 ( 2 ) page： 362-369 2010.2

Language：English Publishing type：Research paper (scientific journal)

PMID: 19543206
The association between BMI and all-cause mortality may vary with gender, age, and ethnic groups. However, few prospective cohort studies have reported the relationship in older Asian populations. We evaluated the association between BMI and all-cause mortality in a cohort comprised 26,747 Japanese subjects aged 65-79 years at baseline (1988-1990). The study participants were followed for an average of 11.2 years. Proportional-hazards regression models were used to estimate mortality hazard ratios (HRs) and 95% confidence intervals. Until 2003, 9,256 deaths occurred. The underweight group was associated with a statistically higher risk of all-cause mortality compared with the mid-normal-range group (BMI: 20.0-22.9); resulting in a 1.78-fold (95% confidence interval: 1.45-2.20) and 2.55-fold (2.13-3.05) increase in mortality risk among severest thin men and women (BMI: <16.0), respectively. Even within the normal-range group, the lower normal-range group (BMI: 18.5-19.9) showed a statistically elevated risk. In contrast, being neither overweight (BMI: 25.0-29.9) nor obese (BMI: > or =30.0) elevated the risk among men; however among women, HR was slightly elevated in the obese group but not in the overweight group compared with the mid-normal-range group. Among Japanese older adults, a low BMI was associated with increased risk of all-cause mortality, even among those with a lower normal BMI range. The wide range of BMI between 20.0 and 29.9 in both older men and women showed the lowest all-cause mortality risk.

Changes in activities of daily living, physical fitness, and depressive symptoms after six-month periodic well-rounded exercise programs for older adults living in nursing homes or special nursing facilities. Reviewed

Ouyang P, Yatsuya H, Toyoshima H, Otsuka R, Wada K, Matsushita K, Ishikawa M, Yuanying L, Hotta Y, Mitsuhashi H, Muramatsu T, Kasuga N, Tamakoshi K.

Nagoya J Med Sci Vol. 71 ( 3-4 ) page： 115-126 2009.9

Healthy lifestyle and preventable death: findings from the Japan Collaborative Cohort (JACC) Study. Reviewed

Tamakoshi A, Tamakoshi K, Lin Y, Yagyu K, Kikuchi S; JACC Study Group.

Prev Med. Vol. 48 ( 5 ) page： 486-492 2009.5

Self-reported medical history was generally accurate among Japanese workplace population. Reviewed

Wada K, Yatsuya H, Ouyang P, Otsuka R, Mitsuhashi H, Takefuji S, Matsushita K, Sugiura K, Hotta Y, Toyoshima H, Tamakoshi K.

J Clin Epidemiol. Vol. 62 ( 3 ) page： 306-313 2009.3

Uric acid and left ventricular hypertrophy in Japanese men. Reviewed

Mitsuhashi H, Yatsuya H, Matsushita K, Zhang H, Otsuka R, Muramatsu T, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H, Tamakoshi K.

Circ J. Vol. 73 ( 4 ) page： 667-672 2009.2

Multilevel analyses of effects of variation in body mass index on serum lipid concentrations in middle-aged Japanese men. Reviewed

Kondo T, Kimata A, Yamamoto K, Ueyama S, Ueyama J, Yatsuya H, Tamakoshi K, Hori Y.

Nagoya J Med Sci. Vol. 71 ( 1-2 ) page： 19-28 2009.2

Effect of the interaction between mental stress and eating pattern on body mass index gain in healthy Japanese male workers. Reviewed

Toyoshima H, Masuoka N, Hashimoto S, Otsuka R, Sasaki S, Tamakoshi K, Yatsuya H.

J Epidemiol Vol. 19 ( 2 ) page： 88-93 2009.2

Effect of physical activity on breast cancer risk: findings of the Japan collaborative cohort study. Reviewed

Suzuki S, Kojima M, Tokudome S, Mori M, Sakauchi F, Fujino Y, Wakai K, Lin Y, Kikuchi S, Tamakoshi K, Yatsuya H, Tamakoshi A; Japan Collaborative Cohort Study Group.

Cancer Epidemiol Biomarkers Prev. Vol. 17 ( 12 ) page： 3396-3401 2008.12

Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: comparison of leptin and adiponectin. Reviewed

Sugiura K, Tamakoshi K, Yatsuya H, Otsuka R, Wada K, Matsushita K, Kondo T, Hotta Y, Mitsuhashi H, Murohara T, Toyoshima H.

Int J Cardiol. Vol. 130 ( 2 ) page： 159-164 2008.11

Low leptin but high insulin resistance of smokers in Japanese men. Reviewed

Hotta Y, Yatsuya H, Toyoshima H, Matsushita K, Mitsuhashi H, Takefuji S, Oiso Y, Tamakoshi K.

Diabetes Res Clin Pract. Vol. 81 ( 3 ) page： 358-364 2008.9

Development and validity of the Japanese version of body shape silhouette: relationship between self-rating silhouette and measured body mass index. Reviewed

Nagasaka K, Tamakoshi K, Matsushita K, Toyoshima H, Yatsuya H.

Nagoya J Med Sci Vol. 70 ( 3-4 ) page： 89-96 2008.8

Having more healthy practice was associated with low white blood cell counts in middle-aged Japanese male and female workers. Reviewed

Otsuka R, Tamakoshi K, Wada K, Matsushita K, Ouyang P, Hotta Y, Takefuji S, Mitsuhashi H, Toyoshima H, Shimokata H, Yatsuya H.

Ind Health Vol. 46 ( 4 ) page： 341-347 2008.8

労働者の肥満と高血圧 Invited

玉腰浩司,八谷寛

血圧 Vol. 15 ( 6 ) page： 51-54 2008.6

*Association between low birth weight and elevated white blood cell count in adulthood within a Japanese population. Reviewed

Wada K, Tamakoshi K, Ouyang P, Otsuka R, Mitsuhashi H, Takefuji S, Matsushita K, Sugiura K, Hotta Y, Toyoshima H, Yatsuya H.

Circ J Vol. 72 ( 5 ) page： 757-763 2008.5

Further inflammatory information on metabolic syndrome by adiponectin evaluation. Reviewed

Matsushita K, Tamakoshi K, Yatsuya H, Wada K, Otsuka R, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H.

Int J Cardiol Vol. 124 ( 3 ) page： 339-344 2008.3

Eating fast leads to insulin resistance: findings in middle-aged Japanese men and women. Reviewed

Otsuka R, Tamakoshi K, Yatsuya H, Wada K, Matsushita K, OuYang P, Hotta Y, Takefuji S, Mitsuhashi H, Sugiura K, Sasaki S, Kral JG, Toyoshima H.

Prev Med. Vol. 46 ( 2 ) page： 154-159 2008.2

Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Reviewed

Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Mori M, Tamakoshi A; Japan Collaborative Cohort Study Group for Evaluation of Cancer Risk.

J Epidemiol Vol. 18 ( 2 ) page： 77-83 2008

Smoking status and adiponectin in healthy Japanese men and women. Reviewed

Takefuji S, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Matsushita K, Sugiura K, Hotta Y, Mitsuhashi H, Oiso Y, Toyoshima H.

Prev Med Vol. 45 ( 6 ) page： 471-475 2007.12

Risk factors for first acute myocardial infarction attack assessed by cardiovascular disease registry data in Aichi Prefecture. Reviewed

Kondo Y, Toyoshima H, Yatsuya H, Hirose K, Morikawa Y, Ikedo N, Masui T, Tamakoshi K.

Nagoya J Med Sci Vol. 69 ( 3-4 ) page： 139-147 2007.10

Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study). Reviewed

Kondo T, Hori Y, Yatsuya H, Tamakoshi K, Toyoshima H, Nishino Y, Seki N, Ito Y, Suzuki K, Ozasa K, Watanabe Y, Ando M, Wakai K, Tamakoshi A.

Cancer Causes Control Vol. 18 page： 229-234 2007

*The transition to menopause reinforces adiponectin production and its contribution to insulin-resistant state. Reviewed

Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, OuYang P, Sugiura K, Yo Hotta Y, Mitsuhashi H, Takefuji S, Kondo T, Toyoshima H.

Clin Endocrinol Vol. 66 page： 65-71 2007

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To evaluate the influence of menopausal status on the serum adiponectin concentration and investigate whether the contribution of adiponectin to insulin resistance is modified by menopausal status. SUBJECTS: We conducted a population-based, cross-sectional study of 207 premenopausal and 206 postmenopausal Japanese women. MEASUREMENTS: Data on anthropometric characteristics, fasting serum adiponectin, glucose and insulin concentrations were used. Insulin resistance (homeostasis model assessment of insulin resistance: HOMA-IR) was calculated. RESULTS: Postmenopausal women had significantly higher HOMA-IRs than premenopausal women [1.50 (1.42, 1.59) vs 1.18 (1.12, 1.24), geometric mean (1 standard error range), P = 0.005]. Paradoxically, adiponectin levels in postmenopausal women were also significantly higher than those in premenopausal women [10.3 (9.95, 10.7) vs 9.04 (8.71, 9.39), P = 0.028]. Multiple regression analysis showed that body mass index (BMI) was the only significantly independent predictor [standardized partial regression coefficients (sbeta) = 0.319, P < 0.001] for HOMA-IR among premenopausal women, whereas both BMI and adiponectin were the significant predictors among postmenopausal (sbeta = 0.334 and -0.141, P < 0.001 and < 0.05, respectively). When the subjects were restricted to those without metabolic disorders including high blood pressure, hypertriglyceridaemia, hypo-HDL cholesterolaemia and high fasting glucose, adiponectin (sbeta = -0.249, P < 0.05) was the only significant predictor for HOMA-IR among postmenopausal women but BMI was not significant (sbeta = 0.223, P = 0.075). CONCLUSIONS: The transition to menopause increases serum adiponectin concentrations. And the significant and negative association between adiponectin and HOMA-IR was observed only after menopause. Therefore, adiponectin may play a role in the improvement of an incipient insulin-resistant state after, rather than before, menopause.

Results of the Health Assessment Questionnaire for Japanese patients with systemic sclerosis--measuring functional impairment in systemic sclerosis versus other connective tissue diseases. Reviewed

Morita Y, Muro Y, Sugiura K, Tomita Y, Tamakoshi K.

Clin Exp Rheumatol Vol. 25 page： 367-372 2007

Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study. Reviewed

Nishio K, Niwa Y, Toyoshima H, Tamakoshi K, Kondo T, Yatsuya H, Yamamoto A, Suzuki S, Tokudome S, Lin Y, Wakai K, Hamajima N, Tamakoshi A.

Cancer Causes Control Vol. 18 page： 801-808 2007

High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk. Reviewed

Matsushita K, Yatsuya H, Tamakoshi K, Yang PO, Otsuka R, Wada K, Mitsuhashi H, Hotta Y, Kondo T, Murohara T, Toyoshima H.

Circ J Vol. 71 page： 820-825 2007

Adiponectin level and left ventricular hypertrophy in Japanese men. Reviewed

Mitsuhashi H, Yatsuya H, Tamakoshi K, Matsushita K, Otsuka R, Wada K, Sugiura K, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H.

Hypertension Vol. 49 page： 1448-1454 2007

Dietary fiber and risk of colorectal cancer in the Japan collaborative cohort study. Reviewed

Wakai K, Date C, Fukui M, Tamakoshi K, Watanabe Y, Hayakawa N, Kojima M, Kawado M, Suzuki K, Hashimoto S, Tokudome S, Ozasa K, Suzuki S, Toyoshima H, Ito Y, Tamakoshi A; JACC Study Group.

Cancer Epidemiol Biomarkers Prev Vol. 16 page： 668-675 2007

White blood cell count and risk of all-cause and cardiovascular mortality in nationwide sample of Japanese--results from the NIPPON DATA90. Reviewed

Tamakoshi K, Toyoshima H, Yatsuya H, Matsushita K, Okamura T, Hayakawa T, Okayama A, Ueshima H; NIPPON DATA90 Research Group.

Circ J Vol. 71 page： 479-485 2007

Psychological factors and insomnia among male civil servants in Japan. Reviewed

Murata C, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Toyoshima H.

Sleep Med Vol. 8 page： 209-214 2007

Psychological attitudes and risk of breast cancer in Japan: a prospective study. Reviewed

Wakai K, Kojima M, Nishio K, Suzuki S, Niwa Y, Lin Y, Kondo T, Yatsuya H, Tamakoshi K, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A; for the JACC Study Group.

Cancer Causes Control Vol. 18 page： 259-267 2007

A positive association between leptin and blood pressure of normal range in Japanese men. Reviewed

Wada K, Yatsuya H, Tamakoshi K, Otsukai R, Fujii C, Matsushita K, Sugiura K, Toyoshima H.

Hypertens Res Vol. 29 page： 485-492 2006

*Eating fast leads to obesity: findings based on self-administered questionnaires among middle-aged Japanese men and women. Reviewed

Otsuka R, Tamakoshi K, Yatsuya H, Murata C, Sekiya A, Wada K, Zhang HM, Matsushita K, Sugiura K, Takefuji S, OuYang P, Nagasawa N, Kondo T, Sasaki S, Toyoshima H.

J Epidemiol Vol. 16 page： 117-124 2006

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Few epidemiologic studies have examined the association between the rate of eating and obesity. In this study, we cross-sectionally examined the association of the self-reported rate of eating with current Body Mass Index (BMI), and BMI-change from 20 years of age to the current age. METHODS: Subjects were 3737 male (mean age +/- standard deviation and mean BMI +/- standard deviation: 48.2 +/- 7.1 years and 23.3 +/- 2.7 kg/m(2)) and 1005 female (46.3 +/- 7.0 years and 21.8 +/- 2.8 kg/m(2)) Japanese civil servants. We measured self-reported categorical rate of eating, current BMI, BMI at age 20, and BMI-change from age 20. Energy intake was assessed over a 1-month period with a brief-type diet history questionnaire. RESULTS: The multiple regression analysis in which the current BMI was regressed by categorical rate of eating, energy intake, age, and lifestyle factors showed that current BMI steadily increased by -0.99, -0.67, 0.81, and 1.47 kg/m(2) along with the progress of categorical rate of eating from the 'medium' group to 'very slow', 'relatively slow', 'relatively fast', and 'very fast' groups, respectively, in men. In women, the corresponding values were -1.06, -0.35, 0.50, and 1.34 kg/m(2). When the BMI increment from age 20 to current age was regressed in the same manner, the increment was -0.63, -0.34, 0.57, and 1.05 kg/m(2) in men and -0.71, -0.32, 0.34, and 1.14 kg/m(2) in women, respectively. Additionally, both BMI at age 20 and current height were positively associated with rate of eating. CONCLUSIONS: Our results among middle-aged men and women suggest that eating fast would lead to obesity.

*Birth weight and adult hypertension: cross-sectional study in a Japanese workplace population. Reviewed

Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Yang PO, Sugiura K, Hotta Y, Mitsuhashi H, Kondo T, Toyoshima H.

Circ J Vol. 70 page： 262-267 2006

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Low birth weight has been associated with adult hypertension in several Western populations. This association needs to be evaluated in Japanese people. METHODS AND RESULTS: A population-based cross-sectional study of 3,107 subjects (2,303 males and 804 females) aged 35-66 years was conducted. The participants responded to a questionnaire about their birth weights, blood pressure, medical history, parental history, and lifestyle factors. Hypertension was defined as systolic blood pressure > or =140 mmHg and/or diastolic blood pressure > or =90 mmHg and/or under treatment by anti-hypertensives. Multiple logistic regression analysis adjusted for age, sex, body mass index, parental history, and lifestyle revealed the adjusted odds ratios for hypertension were 1.26 (95% confidence interval: 0.88-1.80), 1.00 (reference), 0.89 (0.73-1.08) and 0.70 (0.49-1.00) in subjects in birth weight categories of <2,500 g, 2,500-<3,000 g, 3,000-<3,500 g, 3,500- g, respectively (p-value for trend =0.009). Furthermore, this inverse association was clearly pronounced in normal-weight subjects. CONCLUSION: Low birth weight was independently associated with adult hypertension in the Japanese workplace population. Our results support the inverse association observed previously in Western populations and suggest that intrauterine environmental insults might lead to permanent changes in the metabolism and structure of the fetal organs influencing the regulation of blood pressure.

Low birth weight is associated with reduced adiponectin concentration in adult. Reviewed

Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Sugiura K, Kondo T, Toyoshima H.

Ann Epidemiol Vol. 16 page： 669-674 2006

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Low birth weight has been associated with metabolic and vascular diseases, but the precise mechanism is debated. Adiponectin is one of the key molecules in metabolic disease, and a decrease in level precedes the onset of type 2 diabetes and development of atherosclerosis. Our aim is to examine whether low birth weight is associated with adiponectin concentration in adult. METHODS: We conducted a population-based cross-sectional study of 2277 subjects (1661 men and 616 women) aged 35 to 66 years who had their self-reported birth weights and adiponectin concentrations measured as adults. RESULTS: After adjusting for potential confounders, including age, sex, current body mass index (BMI), smoking status, alcohol consumption, and exercise, geometric mean adiponectin levels were 6.63, 6.45, 6.86, 7.05, 6.75, and 7.22 microg/mL for subjects with birth weights less than 2500, 2500 to less than 2800, 2800 to less than 3000, 3000 to less than 3200, 3200 to less than 3500, and greater than 3500 g, respectively. A positive association was found between birth weight and adiponectin concentration (trend p = 0.002). Stratified by current BMI of 25 kg/m2, a positive association was not observed for subjects with a BMI less than 25 kg/m2, but was pronounced in those with a BMI of 25 kg/m2 or greater. CONCLUSION: This study indicates that low birth weight contributes to decreased adiponectin concentrations in adult life independently of current BMI, especially for obese subjects.

Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. Reviewed

Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Zhang H, Sugiura K, Kondo T, Murohara T, Toyoshima H.

Atherosclerosis Vol. 188 page： 184-189 2006

Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. Reviewed

Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Takefuji S, Sugiura K, Kondo T, Murohara T, Toyoshima H.

Arterioscler Thromb Vasc Biol Vol. 26 page： 871-876 2006

Association between parental histories of hypertension, diabetes and dyslipidemia and the clustering of these disorders in offspring. Reviewed

Wada K, Tamakoshi K, Yatsuya H, Otsuka R, Murata C, Zhang H, Takefuji S, Matsushita K, Sugiura K, Toyoshima H.

Prev Med Vol. 42 page： 358-363 2006

Methods for myometrium closure and other factors impacting effects on cesarean section scars of the uterine segment detected by the ultrasonography . Reviewed

Hayakawa H, Itakura A, Mitsui T, Okada M, Suzuki M, Tamakoshi K, Kikkawa F.

Acta Obstet Gynecol Scand Vol. 85 page： 429-434 2006

Determinants of self-rated health: Could health status explain the association between self-rated health and mortality? . Reviewed

Murata C, Kondo T, Tamakoshi K, Yatsuya H , Toyoshima H.

Arch Gerontol Geriatr Vol. 43 page： 369-380 2006

Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren. Reviewed

Fujii C, Sakakibara H, Kondo T, Yatsuya H, Tamakoshi K, Toyoshima H.

J Epidemiol Vol. 16 page： 64-70 2006

Factors related to frequency of engaging in outside activities among elderly persons living an independent life at home. Reviewed

Ishikawa M, Tamakoshi K, Yatsuya H, Suma K, Wada K, Otsuka R, Matsushita K, Zhang H, Murata C, Kondo T, Toyoshima H.

Nagoya J Med Sci Vol. 68 page： 121-130 2006

Factors associated with life space among community-living rural elders in Japan. Reviewed

Murata C, Kondo T, Tamakoshi K, Yatsuya H, Toyoshima H.

Public Health Nursing Vol. 23 page： 324-331 2006

Perceived psychological stress and serum leptin concentration in Japanese men. Reviewed

Otsuka R, Yatsuya H, Tamakoshi K, Matsushita K, Wada K, Toyoshima H.

Obesity Vol. 14 page： 1-7 2006

Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. Reviewed

Niwa Y, Yatsuya H, Tamakoshi K, Nishio K, Kondo T, Lin Y, Suzuki S, Wakai K, Tokudome S, Yamamoto A, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

J Obstet Gynaecol Res. Vol. 31 ( 5 ) page： 452-458 2005.10

Language：English Publishing type：Research paper (scientific journal)

AIM: The incidence of ovarian cancer in Japan has increased since the 1970s. The many studies that have assessed the relationship between body mass index (BMI) and the risk of ovarian cancer have produced contradictory results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, which was initiated in 1988. METHODS: A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 36,456 Japanese women. After 7.6 years of follow up, 38 cases of ovarian cancer were available for analysis. Cox proportional-hazards models were used to compute relative risks and to adjust for confounders. RESULTS: Compared to women with BMI of 18.5-24.9 kg/m2, the relative risk of ovarian cancer was 2.24 (95% CI = 1.10-4.21) for BMI of 25.0-29.9 and 1.78 (95% CI = 0.24-13.34) for BMI of > or = 30 kg/m2. A test for trend revealed that this finding was statistically significant (P = 0.014). CONCLUSION: The results of this study suggest that being overweight is independently associated with a higher risk of developing ovarian cancer in the Japanese population.

Prospective study of alcohol consumption and breast cancer risk in Japanese women. Reviewed

Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A.

Int J Cancer. Vol. 116 ( 5 ) page： 779-783 2005.9

Language：English Publishing type：Research paper (scientific journal)

Epidemiologic evidence is lacking for the association between alcohol consumption and the risk of breast cancer in Japanese women. We addressed this association in a prospective cohort study with an average follow-up of 7.6 years. At baseline (1988-1990), cohort participants completed a self-administered questionnaire that included alcohol use, reproductive history and hormone use. The women were followed up for breast cancer incidence through December 31, 1997. Cox proportional hazards models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for breast cancer incidence and any association with alcohol consumption. During a follow-up of 271,412 person-years, we identified 151 women with breast cancer, of whom 45 were current drinkers and 11 drank > or =15 g of alcohol/day. After adjustment for age and other potential risk factors for breast cancer, the RR for current drinkers was 1.27 (95% CI 0.87-1.84) compared to nondrinkers. Average alcohol intake of <15 g/day did not significantly increase the risk for breast cancer. However, risk was significantly increased for women who consumed > or =15 g/day of alcohol (RR = 2.93, 95% CI 1.55-5.54). Age at starting drinking and frequency of consumption per week were not significantly associated with breast cancer risk. Our cohort study demonstrated that Japanese women who consume at least a moderate amount of alcohol have an increased risk of breast cancer.

Validity of self-reported height and weight in a Japanese workplace population. Reviewed

Wada K, Tamakoshi K, Tsunekawa T, Otsuka R, Zhang H, Murata C, Nagasawa N, Matsushita K, Sugiura K, Yatsuya H, Toyoshima H.

Int J Obes Relat Metab Disord. Vol. 29 ( 9 ) page： 1093-1099 2005.9

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To assess the validity of self-reported height and weight in a Japanese workplace population, and to examine factors associated with the validity of self-reported weight. DESIGN: Comparison of self-reported height and weight with independent measurement. SUBJECTS: In total, 4253 men and 1148 women aged 35-64 y (mean measured body mass index (BMI): 23.3 kg/m(2) in men, 21.9 kg/m(2) in women) were included in the study. MEASUREMENTS: Self-reported height and weight were obtained by a self-administered questionnaire. Measured height and weight were based on annual health checkups. Sex, age, measured BMI, and the presence of hypertension, diabetes, and hyperlipidemia were examined as potential factors associated with the accuracy of self-reported weight. RESULTS: Self-reported height and weight were highly correlated with measured height and weight for men and women (Pearson's r for men and women: 0.979 and 0.988 in height, 0.961 and 0.959 in weight, 0.943 and 0.950 in BMI, respectively). For men, mean differences+/-2 s.d. of height and weight were 0.078+/-2.324 cm and -0.034+/-5.012 kg, respectively, and for women 0.029+/-1.652 cm and 0.024+/-4.192 kg, respectively. The prevalence of obesity with BMI > or =25 kg/m(2) based on self-reported data (23.6 and 11.5% for men and women, respectively) was slightly smaller than that based on measured data (24.9 and 12.4%, respectively). Specificity and sensitivity, however, were quite high for both men and women (sensitivity was 85.8 and 85.2%, and specificity was 97.0 and 98.9%, respectively). The subjects with higher measured BMI significantly underestimated their weight compared with those with smaller BMI after adjustments for age in men and women. Furthermore, the presence of diabetes in men and age in women affected self-reported weight. Neither the presence of hypertension nor hyperlipidemia was associated with reporting bias. CONCLUSION: The self-reported height and weight were generally reliable in the middle

Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. Reviewed

Wakai K, Tamakoshi K, Date C, Fukui M, Suzuki S, Lin Y, Niwa Y, Nishio K, Yatsuya H, Kondo T, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A; JACC Study Group.

Cancer Sci. Vol. 96 ( 9 ) page： 590-599 2005.9

Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women. Reviewed

Mabuchi T, Yatsuya H, Tamakoshi K, Otsuka R, Nagasawa N, Zhang H, Murata C, Wada K, Ishikawa M, Hori Y, Kondo T, Hashimoto S, Toyoshima H.

Diabetes Metab Res Rev. Vol. 21 ( 5 ) page： 441-447 2005.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. METHODS: Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were analyzed in relation to their WBC count. Serum leptin concentrations and WBC counts were measured by radioimmunoassay and automated particle counter respectively, using samples obtained at the time of the participants' annual health checkups. RESULTS: The geometric mean (+/-geometric standard deviation) leptin concentrations were 3.25 +/- 1.82 ng/mL and 6.25 +/- 3.99 ng/mL, and the geometric mean WBC counts, 5770 +/- 1269/mm(3) and 5107 +/- 1228/mm(3), in men and women respectively. The WBC count adjusted for age, body mass index (BMI), physical activity, and drinking and smoking habits increased together with the increase in leptin concentration. Multiple linear regression against WBC count by the leptin concentration and those covariates revealed a significant and independent association with serum leptin concentration especially in women (standardized beta = 0.31, p < 0.001), and also in men (standardized beta = 0.17, p < 0.001). BMI was not significantly associated with WBC counts in the multivariate model adjusting for leptin levels in both sexes. CONCLUSIONS: Our results are in line with leptin's hematopoietic or proinflammatory functions. The increased WBC counts often observed in obese people would be mediated by the increased leptin concentration.

Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan. Reviewed

Tamakoshi K, Toyoshima H, Wakai K, Kojima M, Suzuki K, Watanabe Y, Hayakawa N, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A.

Oncology. Vol. 68 ( 4-6 ) page： 454-461 2005.7

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To elucidate whether leptin is involved in the etiology of female colorectal cancer. METHODS: A case-control study nested in the Japan Collaborative Cohort Study. We compared serum leptin levels in 58 cases of female colorectal cancer with those in 145 controls matched for study area and age. Data were analyzed using a conditional logistic regression model with adjustments for known risk factors for the development of colorectal cancer. Quintile cutoff points were determined on the distribution of leptin levels in cases and controls combined. RESULTS: Serum geometric mean levels of leptin were 6.88 ng/ml in cases and 6.00 ng/ml in controls. The odds ratios of female colorectal cancer risk were 1.40 (95% confidence interval, CI: 0.41-4.78) for the category of the second and third quintiles combined, and 4.84 (CI: 1.29-18.1) for the category of the fourth and fifth quintiles combined relative to the first quintile after adjustment for body mass index (BMI), life-style factors, reproductive factors, and hormonal variables including insulin-like growth factor and its binding protein. CONCLUSION: Our results suggest that leptin most likely increases the risk of female colorectal cancer substantially independent of BMI.

Serum levels of insulin-like growth factor I, II, and binding protein 3, transforming growth factor beta-1, soluble fas ligand and superoxide dismutase activity in stomach cancer cases and their controls in the JACC Study. Reviewed

Yatsuya H, Toyoshima H, Tamakoshi K, Tamakoshi A, Kondo T, Hayakawa N, Sakata K, Kikuchi S, Hoshiyama Y, Fujino Y, Mizoue T, Tokui N, Yoshimura T; JACC Study Group.

J Epidemiol. Vol. S2 page： S120-125. 2005.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The prognosis of stomach cancer with advanced stage remains poor. New biomarkers of the disease that may contribute to establish the potential screening strategy would be of value for the early detection of individuals at high risk of the disease. METHODS: We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the Japan Collaborative Cohort (JACC) Study, to evaluate serum levels of insulin-like growth factor I, II, and binding protein 3 (IFG-I, IGF-II, and IGFBP-3), transforming growth factorbeta-1 (TGFbeta1), soluble fas (sFas) and superoxide dismutase activity (SOD) in 210 stomach cancer cases diagnosed in the JACC Study in relation to those levels in their 410 controls. RESULTS: Among 6 serum biomarkers tested for case-control differences, only sFas level in female stomach cancer cases was significantly higher than that of controls (2.22 pg/ml vs. 2.04 pg/mL, respectively; P=0.013 by two-way analysis of covariance controlling for matching variable). CONCLUSION: None of the biomarkers consistently predicted future risk of stomach cancer in both men and women in the present analysis. Serum sFas level in women, however, should be studied much more thoroughly whether it provides meaningful refinement of risk stratification, or it elucidate the mechanisms of tumorigenesis in women.

Medical history of circulatory diseases and colorectal cancer death in the JACC Study. Reviewed

Watanabe Y, Ozasa K, Ito Y, Suzuki K, Kojima M, Suzuki S, Tokudome S, Tamakoshi K, Toyoshima H, Kawado M, Hashimoto S, Hayakawa N, Wakai K, Tamakoshi A; JACC Study Group.

J Epidemiol. Vol. S2 page： S168-172 2005.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Host factors expressed by individual past medical history of hypertension, stroke, and myocardial infarction may have a relationship with colorectal cancer. METHODS: As part of the Japan Collaborative Cohort Study (JACC Study) for the Evaluation of Cancer Risk sponsored by the Ministry of Education, Science, Sports and Culture of Japan (Monbusho), we conducted a follow-up study of 110,792 Japanese inhabitants aged 40-79 years to reveal the relationship of past medical history of hypertension, stroke, and myocardial infarction at the baseline in 1988-1990 with colorectal cancer death for about 10 years up to the end of 1999. RESULTS: Past medical history of hypertension associated with an increased risk of female rectal cancer when analyzing all cancer cases with adjustment for age, body mass index, and exercise (hazard ratio [HR]=1.97, 95% confidence interval [CI]; 1.13-3.43). Past medical history of myocardial infarction was also an increased risk for female rectal cancer (HR=3.05, 95% CI; 1.28-7.28). Females who had a medical history of stroke had increased risk of rectal cancer without statistical significance. CONCLUSION: There was a positive association of past medical history of hypertension and myocardial infarction and an increased risk of rectal cancer in women.

Colorectal cancer and serum C-reactive protein levels: a case-control study nested in the JACC Study. Reviewed

Ito Y, Suzuki K, Tamakoshi K, Wakai K, Kojima M, Ozasa K, Watanabe Y, Kawado M, Hashimoto S, Suzuki S, Tokudome S, Toyoshima H, Hayakawa N, Kato K, Watanabe M, Ohta Y, Maruta M, Tamakoshi A; JACC Study Group.

J Epidemiol. Vol. S2 page： S185-189 2005.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Recently, it has been hypothesized that inflammation increases the risk of colorectal cancer. We investigated whether serum levels of C-reactive protein (CRP), a biomarker of inflammation, are associated with colorectal cancer, using serum samples collected in the Japan Collaborative Cohort Study (JACC Study). METHODS: We conducted a nested case-control study in the JACC Study, investigating the relationship between the risk for colorectal cancer and serum levels of CRP determined by a high-sensitivity CRP enzyme immunoassay. The subjects recruited were 141 patients with colorectal cancer (63 males and 78 females) and 327 controls with no history of cancer (148 males and 179 females). Each case of colorectal cancer was matched for sex, age and participating institution to 2 or 3 controls. We used ttest to analyze mean differences in CRP levels between colorectal cancer cases and controls. Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using a conditional logistic regression model after adjusting for the potential confounding factors. RESULTS: Serum CRP levels were not clearly associated with the risk of colorectal cancer. The OR of the highest serum CRP levels was 1.18 (95% CI: 0.68-2.06) for colorectal cancer and 1.42 (95% CI: 0.73-2.74) for colon cancer, compared to subjects with lowest serum levels. The OR for incidence of colorectal cancer showed a similar trend, but the difference was not significant. Thus, high serum CRP levels did not appear to increase the risk of colorectal cancer. CONCLUSIONS: The present results suggest that high serum CRP levels are not associated with the risk of colorectal cancer in the JACC Study.

Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese People. Reviewed

Ozasa K, Ito Y, Suzuki K, Watanabe Y, Kojima M, Suzuki S, Tokudome S, Tamakoshi K, Toyoshima H, Kawado M, Hashimoto S, Hayakawa N, Wakai K, Tamakoshi A; JACC Study Group.

J Epidemiol. Vol. S2 page： S180-184 2005.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Glucose intolerance may increase the risk of developing colorectal cancer. METHODS: In a sero-epidemiological nested case-control study, conducted as part of the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk, we measured serum glycoalbumin in 123 patients with colorectal cancer and 279 controls. Conditional logistic regression was used to evaluate the risk of colorectal cancer. RESULTS: There were trends towards an association between high levels of glycoalbumin and an increased risk of colorectal cancer in men (odds ratio [OR]=2.39; 95% confidence interval [CI]; 0.89- 6.36) and between high levels of glycoalbumin and a decreased risk of colorectal cancer in women (OR=0.41; 95% CI, 0.14-1.04). CONCLUSIONS: A high level of glycoalbumin may increase the risk of colorectal cancer in men. The finding that high levels of glycoalbumin in women decreased their risk of colorectal cancer was inconsistent with previous reports, and may have been the result of limitations in the procedure in selecting samples and statistical power.

Alcohol consumption and colorectal cancer risk: findings from the JACC Study. Reviewed

Wakai K, Kojima M, Tamakoshi K, Watanabe Y, Hayakawa N, Suzuki K, Hashimoto S, Kawado M, Tokudome S, Suzuki S, Ozasa K, Toyoshima H, Ito Y, Tamakoshi A; JACC Study Group.

J Epidemiol. Vol. S2 page： S173-179 2005.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Because alcohol drinking is a potential risk factor for colorectal cancer, the trend in alcohol consumption in Japan may partly explain the increase in incidence and mortality rates of this malignancy until 1990-1995. METHODS: We analyzed data from the Japan Collaborative Cohort Study. From 1988 to 1990, 23,708 men and 34,028 women, aged 40-79 years, completed a questionnaire on lifestyle factors including drinking habits. Incidence rate ratios (IRR) were estimated by using proportional hazards models. RESULTS: During the mean follow-up of 7.6 years through December 1997, we documented 418 incidents of colon cancer and 211 of rectal cancer. Male ex- or current drinkers demonstrated a twofold risk for colon cancer compared with nondrinkers: the multivariate-adjusted IRR was 2.01 (95% confidence interval [CI] 1.09-3.68) for ex-drinkers and 1.97 (95% CI: 1.28-3.03) for current drinkers. The doseresponse relationship between alcohol consumption and the risk, however, was not clear. Female exdrinkers were at an increased risk without statistical significance. For rectal cancer, we found a slightly lower risk in light current drinkers who consumed less than 22 g ethanol per day: the multivariate IRR was 0.61 (95% CI: 0.33-1.13) for men and 0.69 (95% CI: 0.27-1.74) for women. Although the IRR for all current drinkers was almost unity in men, an increasing trend in risk was detected with increasing alcohol consumption in current drinkers (trend p=0.027). CONCLUSIONS: Taking the findings from our study and other prospective investigations into consideration, more attention should be paid to alcohol consumption in the prevention of colon cancer in Japan.

Effects of social relationships on mortality among the elderly in a Japanese rural area: an 88-month follow-up study. Reviewed

Murata C, Kondo T, Hori Y, Miyao D, Tamakoshi K, Yatsuya H, Sakakibara H, Toyoshima H.

J Epidemiol. Vol. 15 ( 3 ) page： 78-84 2005.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The association between social relationships and lower mortality has been well documented in Western countries. This study aims to investigate that association among elderly Japanese in a rural area. METHODS: An analysis was conducted with 1,994 subjects (58.1% women), 78.3% of the total elderly aged 65 and older in a town, who were independent in activities of daily living. A baseline survey was carried out in 1992, and subjects were followed until 1999. Cox proportional hazard models examined the association between social relationships (availability of casual friend/ support provider, group membership, job, living arrangement) and an 88-month mortality. RESULTS: A significant association between social relationships and mortality was observed among the old-old (aged 75 and older). Among men, having a job and group membership were significantly associated with lower mortality with hazard ratios (95% confidence intervals) of 0.62 (0.41-0.94) and 0.60 (0.40-0.90), respectively, after adjustment for age, diagnosed illnesses, self-rated health, other social relationships, annual income, and home ownership. Among women, having a job and living alone were significantly associated with lower mortality with hazard ratios (95% confidence intervals) of 0.67 (0.45-0.99) and 0.35 (0.13-0.97), respectively. CONCLUSIONS: Social relationships such as having a job and group membership were associated with lower mortality among the old-old. In addition, old-old women living alone were better off in terms of mortality after adjustment for possible confounders. This suggests the importance of considering family relationships in terms of quality in areas where multi-generation households prevail.

Cigarette smoking and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort study. Reviewed

Niwa Y, Wakai K, Suzuki S, Tamakoshi K, Lin Y, Yatsuya H, Kondo T, Nishio K, Yamamoto A, Tokudome S, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

J Obstet Gynaecol Res. Vol. 31 ( 2 ) page： 144-151 2005.4

Language：English Publishing type：Research paper (scientific journal)

AIM: The many studies into the relation between cigarette smoking and the risk of ovarian cancer have produced inconsistent results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, initiated in 1988. METHODS: A self-administered questionnaire on smoking habits and other risk factors for cancer was completed by 34 639 Japanese women. After 7.6 years of follow up, 39 cases of ovarian cancer were available for analyses. Cox proportional-hazards models were used to compute relative risks (RR) and to adjust for confounders. RESULTS: Relative to those who had never smoked, the RR of ovarian cancer were 1.63 (95% confidence interval [CI] = 0.21-12.50) for former smokers and 2.27 (95% CI = 0.85-6.08) for current smokers. Among current smokers, the RR were 1.48 (95% CI = 0.20-10.92), 5.56 (95% CI = 1.68-19.06), and 1.86 (95% CI = 0.25-14.30) among women who smoked <10, 10-19, and at least 20 pack-years ([number of cigarettes smoked per day/20] x number of years subject has smoked), respectively, relative to those who had never smoked. A test for trend was statistically significant (P = 0.044). CONCLUSIONS: These data indicate that cigarette smoking increases the risk of developing ovarian cancer in the Japanese population.

Lack of an association between serum level of transforming growth factor beta -1 and stomach cancer risk in the JACC study. Reviewed

Yatsuya H, Tamakoshi A, Tamakoshi K, Hoshiyama Y, Fujino Y, Tokui N, Mizoue T, Kikuchi S, Sakata K, Hayakawa N, Kondo T, Toyoshima H, Yoshimura T.

Asian Pac J Cancer Prev. Vol. 6 ( 2 ) page： 170-176 2005.4

Language：English Publishing type：Research paper (scientific journal)

Alterations in the serum concentration of transforming growth factor beta-1 (TGFbeta1) have been observed in gastric cancer patients. No study, however, has ever examined the association between the serum TGFbeta1 level and stomach cancer prospectively. We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the JACC Study to assess whether serum level of total TGFbeta1 is associated with a subsequent risk of stomach cancer. The concentration of serum TGFbeta1 in previously collected blood samples was analyzed by ELISA for 209 individuals in whom a diagnosis of stomach cancer was documented, and for 409 controls matched with them for gender, age and study area. Baseline blood levels of TGFbeta1 were not related to the risk of stomach cancer in either men or women, a finding unchanged even after adjustment for potential confounders. The multivariate-adjusted odds ratio of stomach cancer in men and women was 1.10 (95% CI, 0.82 to 1.48) and 1.09 (95% CI, 0.80 to 1.48), respectively, for each increase of 1 SD in the TGFbeta1 value. In conclusion, serum TGFbeta1 levels were not associated with increased risks of subsequent stomach cancer.gene A52C polymorphism related to the metabolism of long-chain fatty acids and oxidized LDL in the etiology of colorectal cancer.

Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: a prospective study. Reviewed

Kojima M, Wakai K, Tokudome S, Suzuki K, Tamakoshi K, Watanabe Y, Kawado M, Hashimoto S, Hayakawa N, Ozasa K, Toyoshima H, Suzuki S, Ito Y, Tamakoshi A; JACC Study Group.

Am J Epidemiol. Vol. 161 ( 5 ) page： 462-471 2005.3

Language：English Publishing type：Research paper (scientific journal)

To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80 degrees C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total omega-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), alpha-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of omega-6 polyunsaturated fatty acids on colorectal cancer risk were detected.

Familial aggregation and coaggregation of history of hypertension and stroke. Reviewed

Kondo T, Toyoshima H, Tsuzuki Y, Hori Y, Yatsuya H, Tamakoshi K, Tamakoshi A, Ohno Y; JACC Study Group.

J Hum Hypertens. Vol. 19 ( 2 ) page： 119-125 2005.2

Language：English Publishing type：Research paper (scientific journal)

We attempted to evaluate familial aggregation and coaggregation of history of hypertension and stroke. Past and family history of hypertension and stroke for 83 089 probands and their relatives were obtained from a data set for the Japan Collaborative Cohort Study for Evaluation of Cancer Risk sponsored by the Ministry of Education (JACC Study), which was initiated from 1988 to 1990. First, evaluation was performed for familial aggregation of each of two disorders using ordinal logistic regression of the generalized estimation equations (GEE) to account for dependence of observations within families. Secondly, in order to evaluate the familial congregation of the history of hypertension and stroke, a GEE-based multivariate probed predictive model was applied. After adjusting for the proband's age, level of obesity, smoking status, drinking status, habitation area, and the gender and type of the relatives, the estimated odds ratios for the intraindividual clustering and familial aggregation of the disease history showed statistically significant relationships. In addition, the history of the two disorders showed a significant relationship in terms of familial coaggregation independently of the aggregation of each disorder itself. Our results confirmed that hypertension and stroke coaggregate strongly within families through possible effects of genetic factors, which, alone or in conjunction with environmental factors, influence susceptibility to both hypertension and stroke.

Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men. Reviewed

Zhang H, Tamakoshi K, Yatsuya H, Murata C, Wada K, Otsuka R, Nagasawa N, Ishikawa M, Sugiura K, Matsushita K, Hori Y, Kondo T, Toyoshima H.

Circ J. Vol. 69 ( 1 ) page： 13-18 2005.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The relation between weight fluctuation and the risk of cardiovascular disease (CVD) is fairly consistent, although the physiologic basis for the relationship is uncertain. In the present study the association between long-term weight fluctuation and the development of metabolic syndrome (MS), a potent CVD risk factor, was investigated. METHODS AND RESULTS: A cross-sectional study of 664 Japanese men aged 40-49 years was conducted. The root mean square error around the slope of weight on age (weight - RMSE) was calculated by a simple linear regression model, in which the subject's actual weights at ages 20, 25, 30 years and 5 years prior to the study, as well as current weight, were dependent variables against the subject's age as the independent variable. Weight-RMSE was significantly and positively associated with the prevalence of each MS components (high blood pressure, hypertriglyceridemia, low-high density lipoprotein-cholesterol, high fasting glucose, and obesity). Such associations, as well as clustering of the MS component together with RMSE increase, were apparent among subjects with body mass index (BMI) <25 kg/m2, although the prevalence of MS or its components was much higher among overweight subjects (BMI >or=25 kg/m2). CONCLUSIONS: Development of MS possibly explains the risk of CVD not only in overweight or obese persons, but also in normal-weight persons with large weight fluctuation.

Perceived psychologic stress and colorectal cancer mortality: findings from the Japan Collaborative Cohort Study. Reviewed

Kojima M, Wakai K, Tokudome S, Tamakoshi K, Toyoshima H, Watanabe Y, Hayakawa N, Suzuki K, Hashimoto S, Kawado M, Suzuki S, Ito Y, Tamakoshi A; JACC Study Group.

Psychosom Med. Vol. 67 ( 1 ) page： 72-77 2005.1

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The purpose of this research was to examine the relationship between perceived psychologic stress and colorectal cancer mortality in a prospective large-scale study. METHODS: Between the years 1988 and 1990, 32,153 men and 45,854 women aged 40 to 79 years were enrolled. Participants completed a self-administered questionnaire that addressed demographic, lifestyle, and psychosocial characteristics. Subjects were subsequently followed for mortality until the end of 1999. Perceived psychologic stress was assessed using the question "Do you feel stress during your daily life?" The 4 possible responses, ranging from "little or none" (1) to "extreme" (4), were dichotomized as low (1 or 2) or high (3 or 4) stress. Relative risks (RRs) with 95% confidence intervals (CIs) for colon and rectal cancer according to the perceived level of stress were estimated using Cox's proportional hazard model. RESULTS: During the follow-up period (average, 9.6 years), 193 colon cancer deaths (96 men and 97 women) and 127 rectal cancer deaths (88 men and 39 women) were confirmed within the study group. Women who reported high stress had a 1.64-fold higher risk of colon cancer mortality (multivariate-adjusted RR, 1.64; 95% CI, 1.01-2.66) compared with those reporting low stress. There was no significant association between perceived stress and female rectal cancer or male colon and rectal cancer mortality. CONCLUSIONS: Perceived psychologic stress was weakly associated with increased mortality from colon cancer in women. No positive or inverse association was found in men. Further studies are needed to confirm our results.

Impact of menstrual and reproductive factors on breast cancer risk in Japan: results of the JACC study. Reviewed

Tamakoshi K, Yatsuya H, Wakai K, Suzuki S, Nishio K, Lin Y, Niwa Y, Kondo T, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A; JACC Study Group.

Cancer Sci. Vol. 96 ( 1 ) page： 57-62 2005.1

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

The incidence of breast cancer among Japanese women, a traditionally low-risk population, has increased substantially. To evaluate the association of reproductive factors with breast cancer risk, we examined 38,159 Japanese women, aged 40-79 years, who responded to a questionnaire on reproductive and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study. During an average 7.6 years of follow-up, we documented 151 incidents of breast cancers. Cox proportional hazards modeling was employed to estimate relative risks (RR) and 95% confidence intervals (CI). There was a significant decline in the risk of breast cancer with increasing parity among parous women (trend P=0.01). Women with four or more parities had a 69% lower risk than uniparous women, a reduced risk was also evident among menopausal women. Breast cancer risk tended to rise with increasing age at first delivery (trend P=0.05), the association being very apparent among menopausal women (trend P=0.02). Compared to the women who had their first delivery before age 25, those who delayed this event until after age 34 had an RR of 2.12 (95% CI: 0.72-6.21) and 3.33 (1.07-10.3) among the overall subjects and the menopausal, respectively. There was no apparent association of breast cancer risk with age at menarche or menopause. Our study concerning reproductive risk factors suggests that breast cancer in Japan is similar to that in Western countries, and that reproductive factors, particularly the number of parity and age at first delivery, might be important in the etiology of breast cancer among Japanese women.

Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort: effect modification by sex for carotenoids. Reviewed

Wakai K, Suzuki K, Ito Y, Kojima M, Tamakoshi K, Watanabe Y, Toyoshima H, Hayakawa N, Hashimoto S, Tokudome S, Suzuki S, Kawado M, Ozasa K, Tamakoshi A; Japan Collaborative Cohort Study Group.

Nutr Cancer. Vol. 51 ( 1 ) page： 13-24 2005

Language：English Publishing type：Research paper (scientific journal)

To examine associations of serum carotenoids, retinol, and tocopherols with colorectal cancer risk, we conducted a case-control study nested within the Japan Collaborative Cohort Study. These micronutrients were measured in prediagnostic serum samples from 116 men and women who developed colorectal cancer during an 8-yr follow-up period and from 298 matched controls. In men, the higher level of serum total carotenoids was associated with a decreased risk: The multivariate-adjusted odds ratio (OR) for the highest vs. the lowest tertile was 0.34 (95% confidence interval [CI] = 0.11-1.00; trend P over tertiles = 0.040). In women, the higher levels of alpha- and and total carotenoids were instead related to an increased risk: The corresponding ORs were 4.72 (95% CI = 1.29-17.3), 2.00 (0.70-5.73), and 2.47 (0.73-8.34), respectively (trend P = 0.007, 0.040, and 0.064, respectively). We also found a somewhat decreasing risk with increased serum retinol in all subjects and alpha-tocopherol in men: The ORs (95% CI) for the highest tertiles were 0.29 (0.11-0.78; trend P over tertiles = 0.010) and 0.29 (0.07-1.17; trend P = 0.098), respectively. The effects of some carotenoids on colorectal cancer risk may be modified by sex or by factors associated with sex, including smoking and drinking habits.

職域コホート男性における血清レプチン濃度と生活習慣との関連

大塚礼, 豊嶋英明, 八谷寛, 張恵明, 和田恵子, 村田千代栄, 堀容子, 近藤高明, 玉腰浩司

日本循環器病予防学会誌 Vol. 40 page： 123-130 2005

出生時体重と成人期の生活習慣病との関連 Reviewed

玉腰浩司、八谷寛、大塚礼、和田恵子、張恵明、豊嶋英明

現代医学 Vol. 52 page： 321-325 2005

Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: a case-control study nested in the Japan Collaborative Cohort Study. Reviewed

Suzuki K, Ito Y, Wakai K, Kawado M, Hashimoto S, Toyoshima H, Kojima M, Tokudome S, Hayakawa N, Watanabe Y, Tamakoshi K, Suzuki S, Ozasa K, Tamakoshi A; Japan Collaborative Cohort Study Group.

Cancer Epidemiol Biomarkers Prev. Vol. 13 ( 11 ) page： 1781-1787 2004.11

Language：English Publishing type：Research paper (scientific journal)

Oxidative stress plays an important role in carcinogenesis, but few epidemiologic studies have examined associations with risk of colorectal cancer. Relationships between serum levels of oxidized low-density lipoprotein (oxLDL) and oxLDL antibody (oLAB) and colorectal cancer risk were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 161 incidents and deaths from colorectal cancer were identified through 1999, and 395 controls were matched for gender, age, and study area. Measurements were taken of serum oxLDL levels in 119 cases and 316 controls and serum oLAB levels in 153 cases and 376 controls. Odds ratios (95% confidence intervals) across quartiles, adjusted for confounding factors, were 1.55 (0.70-3.46), 1.90 (0.84-4.28), and 3.65 (1.50-8.92) for oxLDL (P(trend) = 0.004) and 0.98 (0.54-1.80), 0.75 (0.39-1.48), and 1.68 (0.90-3.13) for oLAB (P(trend) = 0.140). Further adjustment for serum total cholesterol and alpha-tocopherol did not materially change these associations. Odds ratio (95% confidence interval) of the highest quartile of serum oxLDL compared with the lowest quartile was 3.40 (1.09-10.58; P(trend) = 0.045). Analyses restricted to colon cancer cases and corresponding controls yielded similar relationships between serum oxLDL and oLAB levels and risk. In conclusion, higher levels of serum oxLDL may increase risk of colorectal cancer.

Association of white blood cell count and clustered components of metabolic syndrome in Japanese men. Reviewed

Nagasawa N, Tamakoshi K, Yatsuya H, Hori Y, Ishikawa M, Murata C, Zhang H, Wada K, Otsuka R, Mabuchi T, Kondo T, Toyoshima H.

Circ J. Vol. 68 ( 10 ) page： 892-897 2004.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The role of inflammation in the genesis of cardiovascular disease has attracted attention and in the present study the association among metabolic syndrome (MS), white blood cell (WBC) count, and insulin concentration was investigated. METHODS AND RESULTS: A cross-sectional study of 3,594 Japanese men aged 34-69 years evaluated the MS components (high blood pressure, hypo-high density lipoprotein (HDL)-cholesterolemia, hypertriglyceridemia, hyperglycemia), as defined by the criteria given in the Third Report of the National Cholesterol Education Program Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults, except for obesity [body mass index (BMI) >/=25 kg/m(2)]. WBC count had a positive correlation with BMI, blood pressure, triglyceride, glucose and insulin, and a negative correlation with HDL-cholesterol. The multi-adjusted means of WBC count and insulin concentration were significantly higher in MS subjects defined as having 3 or more of the components than in non-MS subjects with no more than 2 components. Both means also increased with the number of MS components (p<0.001 for trend). In the multiple linear regression analysis, BMI, HDL-cholesterol, systolic blood pressure, glucose and triglyceride had a significant and independent association with WBC count, but the insulin concentration did not. CONCLUSIONS: The cluster of MS components based on insulin resistance may cause low-grade inflammation.

Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study. Reviewed

Yatsuya H, Toyoshima H, Tamakoshi A, Kikuchi S, Tamakoshi K, Kondo T, Mizoue T, Tokui N, Hoshiyama Y, Sakata K, Hayakawa N, Yoshimura T; Japan Collaborative Cohort Study Group.

Br J Cancer. Vol. 91 ( 5 ) page： 929-934 2004.8

Language：English Publishing type：Research paper (scientific journal)

We used 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study For Evaluation of Cancer Risk (JACC study) to investigate whether family history has an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection. A positive history of stomach cancer in one or more first-degree relatives was associated with an increased risk of the disease in women, but not in men after controlling for H. pylori infection and other confounding variables. Women with both a family history and H. pylori infection were associated with more than five-fold increased risk of the disease (OR 5.10, 95% CI 1.58-16.5) compared to those without these factors. These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone.

A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: findings from the JACC study. Reviewed

Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A; JACC Study Group.

Cancer Sci. Vol. 95 ( 7 ) page： 602-607 2004.7

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

The effects of reproductive factors on the etiology of colon cancer in Asian populations remain unexplored. So we examined 38,420 Japanese women aged 40-79 years who responded to a questionnaire on reproductive and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. During an average 7.6 years of follow-up, we documented 207 incident colon cancers. Multivariate analysis indicated that colon cancer risk was likely to be lower among parous women than among nulliparous. Women who had two abortions or more had a 72% higher risk of developing colon cancer [relative risk (RR) 1.72; 95% confidence interval (CI) 1.16-2.55; trend P < 0.01] compared with women who never had an abortion. The RR of colon cancer among postmenopausal women significantly decreased with increasing age at menarche (trend P = 0.01). No apparent association between colon cancer and gravida, age at first birth, age at menopause, or duration of menstruation was seen. These prospective data support the hypothesis that female reproductive events modify colon cancer risk, and suggest that reproductive factors, particularly age at menarche and having an abortion, may be of importance in the etiology of colon cancer among Japanese women.

Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha. Reviewed

Sumigama S, Ito T, Kajiyama H, Shibata K, Tamakoshi K, Kikkawa F, Williams T, Tainsky MA, Nomura S, Mizutani S.

Oncogene. Vol. 15 ( 32 ) page： 5496-5504 2004.7

Language：English Publishing type：Research paper (scientific journal)

A previous report demonstrated that AP-2alpha favors the survival of ovarian cancer patients by clinical findings. However, the functional roles of AP-2alpha in human ovarian cancers have not been determined. To clarify the roles, we overexpressed AP-2alpha in SKOV3 human ovarian cancer cells, which originally possess little AP-2alpha. AP-2alpha overexpression changed cell morphology from spindle to epithelioid type and suppressed cell proliferation and invasion, which would be partially correlated with decreased phosphorylation levels of the erbB2, Akt and ERK pathways, increased E-cadherin and reduced pro-matrix metalloproteinase-2 levels. Moreover, nude mice intraperitoneally injected with AP-2alpha-overexpressing cells survived longer than those with neo-transfected cells. The present data represent the first direct evidence that AP-2alpha plays a tumor suppressive role in ovarian cancer.

A prospective study of body size and colon cancer mortality in Japan: The JACC Study. Reviewed

Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

Int J Obes Relat Metab Disord. Vol. 28 ( 4 ) page： 551-558 2004.4

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To determine whether body size measurements are risk factors for colon cancer death among the Japanese. DESIGN AND SUBJECTS: A nationwide prospective study, the Japan Collaborative Cohort (JACC) Study from 1988 to 1999. The present analysis included 43 171 men and 58 775 women aged 40-79 y who respond to a questionnaire on current weight and height, weight around 20 y of age, and other lifestyle factors. Body mass index (BMI) at baseline and 20 y of age (B-BMI and 20-BMI, respectively) were calculated. RESULTS: We identified 127 deaths from colon cancer during the follow-up of 424 698 person-years among men and 122 deaths during the follow-up of 591 787 person-years among women. After adjustments for the lifestyle factors known to modify the risk of colon cancer, weight at baseline showed a significant positive association in women, while no such association was seen in men. There was also a significant trend of increasing risk with the increase in B-BMI among women. Women with B-BMI >/=28 kg/m(2) had a relative risk (RR) of 3.41 (95% confidence interval (CI): 1.44-8.06) compared with those with BMI of 20-<22 kg/m(2). 20-BMI also presented the same trend of increasing risk as B-BMI. Women with 20-BMI of <22 and B-BMI of >26 kg/m(2), that is, excessive BMI gain, had a high RR of 3.41 (95% CI 1.29-9.02) compared with those with 20-BMI of <22 and B-BMI of <22 kg/m(2). There were no corresponding trends of colon cancer risk for B-BMI, 20-BMI, or BMI change among men. CONCLUSIONS: These study data suggest that obesity and excessive weight gain are associated with the risk of colon cancer death in Japanese women but no such relationship was found in Japanese men.

Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women. Reviewed

Kojima M, Wakai K, Tokudome S, Tamakoshi K, Toyoshima H, Watanabe Y, Hayakawa N, Suzuki K, Hashimoto S, Ito Y, Tamakoshi A; JACC Study Group.

Br J Cancer Vol. 90 ( 7 ) page： 1397-1401 2004.4

Language：English Publishing type：Research paper (scientific journal)

The relationship between bowel movement (BM) frequency and the risk of colorectal cancer was examined in a large cohort of 25 731 men and 37 198 women living in 24 communities in Japan. At enrolment, each participant completed a self-administrated questionnaire on BM frequency and laxative use. Incidence rate ratios (IRR) with 95% confidence intervals (CI) were estimated using Cox's proportional-hazard model. During the follow-up period (average length 7.6 years), 649 cases of colorectal cancer, including 429 cases of colon cancer, were identified. Among women, subjects who reported a BM every 2-3 days had the lowest risk of developing colorectal (IRR=0.71, 95% CI=0.52-0.97) and colon cancer (IRR=0.70, 95% CI=0.49-1.00), whereas those reporting a BM every 6 days or less had an increased risk of developing colorectal (IRR=2.47, 95% CI=1.01-6.01) and colon cancer (IRR=2.52, 95% CI=0.93-6.82) compared with those reporting >or=1 BM per day. A similar, but nonsignificant, association between the frequency of BM and cancer risk was observed in men. There was no association between colorectal or colon cancer risk and laxative use. Regulating BM frequency might therefore have a role in the prevention of colorectal cancer.

A prospective study on the possible association between having children and colon cancer risk: findings from the JACC Study. Reviewed

Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

Cancer Sci. Vol. 95 ( 3 ) page： 243-247 2004.3

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

If having children is regarded as an exposure in life, its effect on a host could be considered as being due to female sex hormones associated with pregnancy in women and some lifestyle factors associated with large families in both men and women. To explore the roles of having children in the etiology of colon cancer, we examined 36,629 women and 24,877 men aged 40-79 years who completed a questionnaire on the number of children and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. During 291,080 and 200,648 person-years of follow-up, we documented 198 female and 202 male incident colon cancers, respectively. After adjusting for some factors known or suspected to modify the risk of colon cancer, compared with the women with no children, the multivariate-adjusted relative risks of colon cancer were 0.74 (95% confidence interval [CI]: 0.30-1.84) for one child, 1.00 (95% CI: 0.46-2.20) for two, 0.70 (95% CI: 0.31-1.55) for three, and 0.59 (95% CI: 0.26-1.33) for four or more. The risk of colon cancer showed a significantly monotonic decrease with increasing number of children (P value for trend = 0.047). There was no association between the number of children and colon cancer risk among men. From these prospective data, having children may reduce risk of colon cancer among women, but not among men, suggesting that modifications of hormone profiles secondary to pregnancies may influence female colon cancer risk.

Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases. Reviewed

Yatsuya H, Tamakoshi K, Hattori H, Otsuka R, Wada K, Zhang H, Mabuchi T, Ishikawa M, Murata C, Yoshida T, Kondo T, Toyoshima H

Circ J Vol. 68 ( 1 ) page： 11-16 2004.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Phospholipid transfer protein (PLTP) can generate pre-beta high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. The transfer of phospholipids to immature HDL is also essential in maintaining reverse cholesterol transport. The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; however, little information is available concerning the relationship between PLTP mass and disease. METHODS AND RESULTS: Using a sandwich enzyme-linked immunosorbent assay, PLTP concentration was measured and related to the risk of developing cardiovascular disease in a worksite-based cohort of Japanese men (n=2,567). Multiple linear regression analysis showed significant associations between PLTP and HDL cholesterol, triglycerides, low-density lipoprotein cholesterol, and body mass index (standardized beta=0.395, -0.191, -0.064, and -0.064, respectively; R(2)=0.31). During the follow-up period, there were 10 cases of coronary heart disease (CHD) and 7 of stroke. The multivariate adjusted relative risk of CHD was 0.46 (95% confidence interval, 0.20-1.07) for an increase of 1 standard deviation in the PLTP value (p=0.071). PLTP concentration was not related to the risk of stroke. CONCLUSIONS: The results of this prospective study indicate that the serum PLTP concentration would serve as a predictor of CHD, independent of HDL cholesterol, triglycerides and other established risk factors.

Diet and colorectal cancer mortality: results from the Japan Collaborative Cohort Study. Reviewed

Kojima M, Wakai K, Tamakoshi K, Tokudome S, Toyoshima H, Watanabe Y, Hayakawa N, Suzuki K, Hashimoto S, Ito Y, Tamakoshi A; Japan Collaborative Cohort Study Group.

Nutr Cancer. Vol. 50 ( 1 ) page： 23-32 2004

Language：English Publishing type：Research paper (scientific journal)

The relationship between diet and colorectal cancer mortality was analyzed in a prospective study of 45,181 men and 62,643 women aged 40-79 yr enrolled in the Japan Collaborative Cohort Study. Between 1988 and 1990, subjects completed a self-administered questionnaire on their sociodemographic characteristics, diet, and other lifestyle habits. During the follow-up period (average 9.9 yr), 284 colon cancer deaths (138 men and 146 women) and 173 rectal cancer deaths (116 men and 57 women) were confirmed. The only significant association of colorectal cancer mortality with vegetable intake was observed between male rectal cancer mortality and green leafy vegetable consumption [hazard ratio (HR) using Cox proportional hazard models = 0.6; 95% confidence interval (CI) = 0.3-0.9; P for trend = 0.02]. Yogurt intake was also inversely associated with male rectal cancer mortality (HR = 0.5; 95% CI = 0.2-1.0; P for trend = 0.04). Egg consumption was positively associated with male colon cancer mortality (P for trend = 0.04). Women with high fruit consumption had increased colon cancer mortality (HR = 1.6; 95% CI = 1.0-2.6; P for trend = 0.04). It should be noted that this study lacked statistical power due to small sample size and measurement error in the food-frequency questionnaire. Further investigation is therefore necessary to confirm the association between diet and colorectal cancer, especially by subsites and gender.

肥満者における心血管疾患発症の過剰リスクを説明する新しい軸　血清レプチン値と白血球数の関連

八谷寛, 間淵智子, 大塚礼, 和田恵子, 長澤伸江, 張恵明, 村田千代栄, 石川美由紀, 堀容子, 近藤高明, 玉腰浩司, 豊嶋英明

Vol. 20 page： 19-25 2004

人間ドックの有効性と限界

玉腰浩司、八谷寛、豊嶋英明

総合臨床 Vol. 53 page： 2435-2338 2004

日本人男性における血清レプチン濃度と5年間追跡後の体重変化

八谷寛, 玉腰浩司, 大塚礼, 間淵智子, 和田恵子, 張恵明, 村田千代栄, 石川美由紀, 近藤高明, 豊嶋英明

健康医科学研究助成論文集 Vol. 19 page： 110-117 2004

肥満を伴った高脂血症患者に対する運動療法の効果に関する研究　行動医学的アプローチを用いた運動習慣の定着による動脈硬化促進要因の改善に関する研究

下光輝一, 井上茂, 小田切優子, 高波嘉一, 豊嶋英明, 八谷寛, 玉腰浩司, 近藤高明, 井口ちよ

医科学応用研究財団研究報告 Vol. 21 page： 215-223 2004

Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men. Reviewed

Tamakoshi K, Yatsuya H, Kondo T, Ishikawa M, Zhang H, Murata C, Otsuka R, Mabuchi T, Hori Y, Zhu S, Yoshida T, Toyoshima H.

Int J Obes Relat Metab Disord. Vol. 27 ( 9 ) page： 1059-1065 2003.9

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To elucidate the effect of long-term weight variability on C-reactive protein (CRP) levels. DESIGN: Cross-sectional study of the circulating CRP. SUBJECTS: A total of 637 Japanese men aged 40-49 y in1997. MEASUREMENTS: Serum CRP levels, body mass index in 1997 (current BMI), the slope of weight on age (weight-slope) representing an individual's weight trend of direction and magnitude, and the root mean square error around the slope of weight on age (weight-RMSE) representing the weight fluctuation magnitude, as calculated by a simple linear regression model in which each value of the subject's five actual weights (aged 20, 25, 30 y, five years ago, and current) was a dependent variable and the subject's ages independent variables. RESULTS: After adjustment for age and confounders, including smoking and health status, the odds ratios of elevated CRP (> or =0.06 mg/dl) were 1.83 (95% CI: 1.25-2.69), 2.63 (1.69-4.11), and 10.31 (2.17-48.98) for upper normal-weight (BMI: 22-<25 kg/m(2)), overweight (25-<30), and obese (> or =30) persons, respectively, compared with lower normal-weight persons (18.5-<22). Adjusting for age, confounders, and current BMI, weight-slope was positively associated with CRP level especially among subjects with BMI> or =25 kg/m(2) (trend P<0.01), and weight-RMSE was positively associated with CRP level particularly among subjects with BMI <25 kg/m(2) (trend P<0.05). CONCLUSION: Our results suggest a state of low-grade systemic inflammation not only in overweight and obese persons, but also in normal-weight persons with large weight fluctuation, possibly explaining in part the positive association between weight fluctuation and CVD.

Association between weight fluctuation and fasting insulin concentration in Japanese men. Reviewed

Yatsuya H, Tamakoshi K, Yoshida T, Hori Y, Zhang H, Ishikawa M, Zhu S, Kondo T, Toyoshima H.

Int J Obes Relat Metab Disord. Vol. 27 ( 4 ) page： 478-483 2003.4

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To investigate whether long-term weight fluctuation is associated with the fasting serum insulin concentration. DESIGN AND SUBJECTS: Weight histories of 1932 male Japanese workers aged 40-59 y were analyzed in relation to their current fasting serum insulin concentration. MEASUREMENTS: Individual weight fluctuation was calculated by root mean square error (RMSE) along the linear regression line of weight measured at five to six different ages. RESULTS: The mean RMSE and fasting insulin concentration were 1.22 kg and 4.5 microU/ml, respectively. The multivariate adjusted insulin level became higher with the increase in weight fluctuation. Subanalysis stratified by current body mass index (BMI) showed that the multivariate adjusted insulin level in individuals in the top quartile of fluctuation was 4.3 microU/ml, against 3.9 microU/ml in those in the bottom quartile (P=0.018, analysis of covariance (ANCOVA)) in the normal weight subgroup with current BMI below 25 kg/m(2). In the overweight subgroup with BMI 25 kg/m(2) or above, the level was 6.9 microU/ml in individuals in the top quartile and 6.2 microU/ml in those in the bottom quartile (P=0.054, ANCOVA). CONCLUSION: The results suggest that weight fluctuation increases the risk of developing hyperinsulinemia. Prospective observations together with measurement of changes in adiposity are needed for confirmation.

*The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state. Reviewed

Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Ishikawa M, Zhang H, Murata C, Otsuka R, Zhu S, Toyoshima H.

Int J Obes Relat Metab Disord. Vol. 27 ( 4 ) page： 443-449 2003.4

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To elucidate the underlying mechanisms between C-reactive protein (CRP) and cardiovascular disease, we examined the association of circulating CRP in healthy reference range (< or =1.0 mg/dl) measured by high-sensitive CRP assay with the metabolic syndrome (MS). DESIGN: Cross-sectional study of circulating CRP in adult men. SUBJECTS: A total of 3692 Japanese men aged 34-69 y. MEASUREMENTS: Serum CRP, total cholesterol, triglycerides, LDL-cholesterol, fasting glucose, fasting insulin, uric acid, systolic blood pressure, diastolic blood pressure, and body mass index (BMI). RESULTS: There was a statistically significant positive correlation between CRP and BMI (r=0.25), total cholesterol (r=0.096), triglycerides (r=0.22), LDL-cholesterol (r=0.12), fasting glucose (r=0.088), fasting insulin (r=0.17), uric acid (r=0.13), systolic blood pressure (r=0.12), and diastolic blood pressure (r=0.11), and a significant negative correlation of CRP with HDL-cholesterol (r=0.24). After adjusting for age, smoking, and all other components of MS, obesity, hypertriglyceridemia, hyper-LDL-cholesterolemia, diabetes, hyperinsulinemia, and hyperuricemia were significantly associated with both mildly (> or =0.06 mg/dl) and moderately (> or =0.11 mg/dl) elevated CRP. Compared with men who had no such components of the MS, those who had one, two, three, four, and five or more components were, respectively, 1.48, 1.84, 1.92, 3.42, and 4.17 times more likely to have mildly elevated CRP levels (trend P<0.001). As for moderately elevated CRP, the same association was observed. CONCLUSIONS: These results indicate that a variety of components of the MS are associated with elevated CRP levels in a systemic low-grade inflammatory state.

U-shaped association between white blood cell count and fasting plasma glucose level. Reviewed

Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Zhang H, Ishikawa M, Murata C, Otsuka R, Zhu S, Toyoshima H.

Diabetes Care. Vol. 26 ( 3 ) page： 950 2003.3

The accuracy of long-term recall of past body weight in Japanese adult men. Reviewed

Tamakoshi K, Yatsuya H, Kondo T, Hirano T, Hori Y, Yoshida T, Toyoshima H.

Int J Obes Relat Metab Disord. Vol. 27 ( 2 ) page： 247-252 2003.2

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To examine the influences of recall period, current body weight, weight gain and loss, and weight variability on the accuracy of long-term recall of past weight. DESIGN AND SUBJECTS: Comparison of recalled weights around 25 y old with weights measured at age 25y in health checkup records among 2453 Japanese men (age: 34-61 y). MEASUREMENTS: Deviations between reported and measured weights were examined as to the three indexes: actual error (reported-measured), percent error (actual error/measured x 100), and absolute value of the percent error. Weight variability was defined as (1) the coefficient of variation of weight (CV) and (2) the root mean square error around the slope of weight on age (RMSE). RESULTS: Recalled weight strongly correlated with measured weight (r=0.849). Correlation coefficients decreased as age or the elapsed time since age 25y increased. Recalled weight (mean=58.3 kg) was slightly greater than measured weight at age 25y (mean=57.0 kg, mean actual error=1.28 kg). Subjects with a current body mass index (BMI) of less than 28.6 kg/m(2) overestimated their past weights, whereas those with BM1 of 28.6 kg/m(2) or over underestimated it. Subjects with weight loss since age 25y underestimated their past weights, whereas those with stable weight or gain overestimated it. There were monotonic increases in the three indexes of deviation across the CV quartile categories. Concerning the effect RMSE, a similar trend was observed. CONCLUSION: These results indicate that past body weights over a long period seem to be recalled with good accuracy. However, it should be kept in mind when using recalled weight in an epidemiologic study that accuracy of recall is influenced by age or elapsed time, current BMI, weight gain and loss, and weight variability.

Trends in the mortality (1950-1997) and incidence (1975-1993) of malignant ovarian neoplasm among Japanese women: analyses by age, time, and birth cohort. Reviewed

Tamakoshi K, Kondo T, Yatsuya H, Hori Y, Kikkawa F, Toyoshima H.

Gynecol Oncol. Vol. 83 ( 1 ) page： 64-71 2001.10

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The purpose of this study was to explore epidemiological features of malignant ovarian neoplasm in Japan. METHODS: The number of deaths from malignant ovarian neoplasm was obtained from the national vital statistics. Estimated incidence rates, based on several cancer registries, were also used for analyses. We divided the subjects into two age groups (0-29 and 30+ years) and examined secular trends in mortality (1950-1997) and incidence (1975-1993) by age, time, and birth cohort. RESULTS: The age-adjusted mortality rate has increased approximately 4-fold (from 0.9 to 3.6 per 100,000 women) from 1950 to 1997. Age-specific mortality rates showed a rising pattern in the elderly, whereas mortality in the younger people tended to increase in the 1950s and 1960s, but then decreased in the 1970s and afterward. In analyses using a mathematical model, the time effect in the population aged 0-29 years increased with advancing period up to 1970, and then decreased. The cohort effects had positive values, which indicate higher than additive influence from age/time effect, for birth cohorts from 1900 to 1935. The age-adjusted incidence rate increased approximately 1.5-fold (from 3.6 to 5.7) from 1975 to 1993. The rate increased in the early 1980s, but has remained stable since the late 1980s. Age-specific incidence rates in older age groups increased steadily up to 1985, and have remained stable since, while the rates in younger women have remained almost unchanged. CONCLUSION: The major effects on malignant ovarian neoplasm in Japan are supposed to be due to declining parity and therapeutic improvements.

Clinical behavior of borderline ovarian tumors: a study of 150 cases. Reviewed

Tamakoshi K, Kikkawa F, Nakashima N, Tamakoshi A, Kawai M, Furuhashi Y, Hattori SE, Kuzuya K, Arii Y, Suganuma N, Tomoda Y.

J Surg Oncol. Vol. 64 ( 2 ) page： 147-152 1997.2

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: We evaluated the clinical features, treatment, and survival status of the patients with borderline ovarian tumors. METHODS: A retrospective review of the charts of 150 patients with borderline ovarian tumor registered at the Tokai Ovarian Tumor Study Group from January 1, 1980, to December 31, 1994, was conducted to obtain clinical and pathological information. RESULTS: In stage II and III disease, the numbers of patients with no residual tumor, residual tumor of <2 cm, 2-5 cm, and >5 cm were 9, 10, 3, and 3, respectively. The sizes of residual tumors and corresponding clinical response to chemotherapy were as follows: residual tumor of <2 cm, complete response (CR), 6 patients; no change (NC), 2; progressive disease (PD), 2; tumors 2-5 cm, NC, 1 patient, PD, 2; tumors >5 cm, PD, 3 patients. The survival for patients with residual tumor <2 cm was significantly better than for those with residual tumor from 2-5 cm and of >5 cm (P < 0.05). The survival for patients with stage II and III serous tumor was significantly longer than that for patients with stage II and III mucinous tumor (P < 0.05). CONCLUSION: In advanced borderline ovarian tumor, the prognosis of patients with gross residual tumor after initial surgery, and especially with mucinous tumor, was poor.

Hyaluronidase activity in gynaecological cancer tissues with different metastatic forms. Reviewed

Tamakoshi K, Kikkawa F, Maeda O, Suganuma N, Yamagata S, Yamagata T, Tomoda Y.

Br J Cancer. Vol. 75 ( 12 ) page： 1807-1811 1997

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

We investigated hyaluronidase activity in gynaecological normal and malignant tissues. Hyaluronidase activity in culture medium of tissue specimens was detected by hyaluronic acid zymography and quantified by densitometry. Hyaluronidase activity was shown as one dominant band (molecular weight 65 kDa) at pH 3.5. Hyaluronidase activity was significantly higher in normal ovary (P < 0.05) and normal endometrium (P< 0.05) than in normal cervix. One dominant 65-kDa hyaluronidase was expressed in 100% (14 out of 14) of ovarian cancer tissues and in 91% (10 out of 11) of endometrial cancer tissues. However, hyaluronidase activity was not observed in cervical cancer tissues. Hyaluronidase activity was significantly higher in ovarian (P < 0.001) and endometrial (P < 0.01) cancer tissues than in cervical cancer tissue and was significantly higher in ovarian cancer tissue than in endometrial cancer tissue (P < 0.05). These facts suggest that the cancer cells make use of the original characteristic of the organ to invade and metastasize. Moreover, these results reflect the difference in metastatic forms and are suggestive of a strong relationship between hyaluronidase activity and invasion and metastasis of ovarian and endometrial cancers compared with cervical cancer.

Clinical value of CA125, CA19-9, CEA, CA72-4, and TPA in borderline ovarian tumor. Reviewed

Tamakoshi K, Kikkawa F, Shibata K, Tomoda K, Obata NH, Wakahara F, Tokuhashi Y, Ishikawa H, Kawai M, Tomoda Y.

Gynecol Oncol. Vol. 62 ( 1 ) page： 67-72 1996.7

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Five tumor markers were analyzed clinically in 101 patients with borderline ovarian tumors who were treated by the Tokai Ovarian Tumor Study Group, an association comprising Nagoya University and its affiliated hospital, between January 1986 and December 1994. The positive rate of CA125 was 68.2% in serous tumor and 51.9% in mucinous tumor. The positive rate of CA19-9 was 51.5% in serous tumor and 44.7% in mucinous tumor. The positive rates and mean serum levels of CA125 in serous and mucinous tumor by stage had rising tendencies with an increase in each stage. The mean serum levels of CA19-9 in serous and mucinous tumor by stage had rising tendencies with an increase in each stage. CA125 and CA19-9 were useful for screening of borderline ovarian tumors. The positive rates of CEA and TPA in mucinous tumor were 32.5 and 27.3%, respectively, although none of the patients with serous tumor were positive in CEA and TPA. The positive rates and mean serum levels of CEA in mucinous tumor by stage had rising tendencies with an increase in each stage. The positive rate of CA72-4 was significantly lower than that of CA125 (P < 0.05).

Characterization of extracellular matrix-degrading proteinase and its inhibitor in gynecologic cancer tissues with clinically different metastatic form. Reviewed

Tamakoshi K, Kikkawa F, Nawa A, Ishikawa H, Mizuno K, Tamakoshi A, Yamagata S, Suganuma N, Tomoda Y.

Cancer. Vol. 76 ( 12 ) page： 2565-2571 1995.12

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND. The authors conducted a comparison study of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) activities in clinically different metastatic types of ovarian cancer, cervical cancer, and endometrial cancer tissues. METHODS. Gelatinase activity in culture medium obtained from each cancer tissue was detected by zymography and was quantitated by densitometer. Tissue inhibitor of metalloproteinase-1 activity was measured in culture medium by the human TIMP-1 enzyme immunoassay kit. RESULTS. Six dominant gelatinases were detected in ovarian, cervical, and endometrial cancers: 200-kDa; 130-kDa; 92-kDa (MMP-9); 83-kDa, which is an active form of 92-kDa gelatinase; 72-kDa (MMP-2); and 66-kDa gelatinase, which is an active form of 72-kDa gelatinase. The 92-kDa and 72-kDa gelatinolytic bands were present in all samples. The expression rates of 200-, 130-, and 83-kDa gelatinase in endometrial cancer and cervical cancer tissues were higher than that observed in ovarian cancer tissue. Densitometric analysis showed that the 92-kDa/72-kDa ratio was significantly higher in cervical cancer tissue than in ovarian and endometrial cancer tissues (P < 0.05), and the 66-kDa/72-kDa ratio was significantly higher in endometrial cancer tissue than in ovarian cancer tissue (P < 0.01). Tissue inhibitor of metalloproteinase-1 activity was significantly lower in cervical cancer tissue than in ovarian and endometrial cancer tissues (P < 0.01). CONCLUSIONS. These results reflect the difference of metastatic forms and are indicative of the possibility of the strong relationship to MMP activity in the invasion and metastasis of cervical cancer and endometrial cancer, compared with those of ovarian cancer.

Clinical value of a new serum tumor marker, CA125II, in gynecologic disease: comparison with CA125. Reviewed

Tamakoshi K, Kikkawa F, Hasegawa N, Ishikawa H, Mizuno K, Kawai M, Tomoda Y.

Gynecol Obstet Invest. Vol. 39 ( 2 ) page： 125-129 1995

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

CA125 II, an improved version of the conventional CA125 was compared with CA125 as to which was more useful in gynecologic disease. In the diagnosis of tumors around the adnexal field (primary epithelial ovarian cancer, metastatic ovarian cancer, benign ovarian tumor and endometrial cyst), CA125 II showed the same sensitivity and specificity as CA125. CA125 II also has high simultaneous reproducibility in the low concentration area. The examination by the receiver operating characteristic curve revealed that CA125 II has higher precision than that of CA125 when it is used for the screening test. In conclusion, CA125 II is a better tumor marker than conventional CA125.

Different pattern of zymography between human gynecologic normal and malignant tissues. Reviewed

Tamakoshi K, Kikkawa F, Nawa A, Maeda O, Kawai M, Sugamuma N, Yamagata S, Tomoda Y.

Am J Obstet Gynecol. Vol. 171 ( 2 ) page： 478-484 1994.8

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Our purpose was to evaluate type IV collagenase in ovarian and endometrial cancer tissues. STUDY DESIGN: Tissue specimens were obtained from patients with ovarian and endometrial cancer and uterine myoma. Gelatinase activity was detected by zymography and quantitated by densitometer. RESULTS: Four dominant gelatinases were detected in ovarian and endometrial cancer tissues: 200, 130, 92, and 72 kd gelatinase. Other forms observed were 83 kd gelatinase, which is an active form of 92 kd gelatinase, and 66 kd gelatinase, which is an active form of 72 kd gelatinase. Densitometric analysis showed that the 92 kd/72 kd ratio in ovarian cancer tissues was significantly higher than in normal ovarian tissues (p < 0.05) and that the 66 kd/72 kd ratio was higher in ovarian cancer tissues (p = 0.07). Both ratios in endometrial cancer tissues were significantly higher than in normal endometrial tissues (p < 0.05). CONCLUSION: Gelatinase activity was remarkably higher in ovarian and endometrial cancer tissues. Especially, 92, 83, and 66 kd gelatinases were clearly detected in cancer tissues, suggesting that these gelatinases were related to the malignant phenotype, because degradation of the components of the basement membrane such as type IV collagen is necessary for cancer cells to metastasize.

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