研究者詳細 - 玉腰　浩司

論文 - 玉腰　浩司

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Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma 査読有り

MAEDA Osamu, SHIBATA Kiyosumi, HOSONO Satoyo, FUJIWARA Sawako, KAJIYAMA Hiroaki, INO Kazuhiko, NAWA Akihiro, TAMAKOSHI Koji, KIKKAWA Fumitaka

Int J Cancer 130 巻 ( 1 ) 頁： 113-121 2012年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

PMID:21328338
To overcome drug resistance in ovarian carcinoma, novel resistance mechanisms must be elucidated for clinical application. We purified 2 proteins in the 300 kDa range from cisplatin-resistant cells (NOS2CR2) by affinity chromatography with cisplatin-exposed Glutathione Sepharose 4B. The purified proteins were identified as spectrin αII and βII by peptide mass mapping analysis. Western blot analysis detected greater expression of spectrin αII and βII in NOS2CR2 than in wild-type cells (NOS2). The same result was obtained for spectrin βII expression by immunohistochemical staining. To determine whether spectrin αII and βII contribute to resistance, a drug sensitivity test was performed on SKOV3 ovarian cancer cells transfected with small interfering RNA. Sensitivity to platinum drugs was increased in the expression reduced cells. In a clinical study of five ovarian serous adenocarcinoma cases, tumor specimens taken after treatment with carboplatin stained more strongly for spectrin βII expression than untreated specimens. Fifty-two tumor specimens from 46 patients with ovarian serous adenocarcinoma were immunohistochemically stained for spectrin βII and scored. Tumors previously treated by chemotherapy scored higher than those not treated. Of 27 cases with detectable residual tumors at the time of surgery, cases scoring 4-6 had shorter progression-free survival periods after platinum-based chemotherapy than cases scoring 0-3 (p = 0.012). The cytoskeleton proteins Spectrin αII and βII contributed to drug resistance by anchoring the GS-Pt complex to the cell membrane, arresting cisplatin activity. Thus spectrin βII may be a useful predictor of platinum sensitivity in ovarian serous adenocarcinoma.

DOI： 10.1002/ijc.25983

Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan. 査読有り

MURO Yoshinao, SUGIURA Kazumitsu, HOSHINO Kei, AKIYAMA Masashi, TAMAKOSHI Koji

Arthritis Res Ther 13 巻 ( 6 ) 頁： 214 2011年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: Several reports have found the onset or activity of inflammatory myopathies to show spatial clustering and seasonal association. We recently detected autoantibodies against melanoma differentiation-associated gene 5 (MDA-5) in more than 20% of patients with dermatomyositis. Anti-MDA-5 antibodies were associated with the presence of rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis (CADM). The present study aims to assess the growing prevalence of CADM and the geographical incidence of anti-MDA-5-positive patients.

METHODS: We reviewed medical charts and examined the presence of anti-MDA-5 antibodies in 95 patients, including 36 CADM patients. Sera were obtained from 1994 through 2011. Statistical analyses were performed to assess whether CADM development and the presence of anti-MDA-5 antibodies were associated with various parameters, including age at disease onset, season of onset, annual positivity, and population of resident city.

RESULTS: Tertiles based on the year when the sera were collected showed increasing tendencies of CADM and anti-MDA-5-positive patients among all of the dermatomyositis patients. From 1994 to 2010, the relative prevalence of CADM and anti-MDA-5 antibody-positive patients significantly increased. Interestingly, the presence of anti-MDA-5 antibodies in 26 patients was inversely associated with the population of their city of residence.

CONCLUSIONS: This is the first study to examine the distribution of anti-MDA-5-positive dermatomyositis phenotypes in Japan. Regional differences in the incidences of these phenotypes would suggest that environmental factors contribute to the production of antibodies against MDA-5, which triggers innate antiviral responses.

Number of children and all-cause mortality risk: results from the Japan Collaborative Cohort Study 査読有り

TAMAKOSHI Akiko, TAMAKOSHI Koji, LIN Yingsong, MIKAMI Haruo, INABA Yutaka, YAGYU Kiyoko, KIKUCHI Syogo; for the JACC Study Group.

Number of children and all-cause mortality risk: results from the Japan Collaborative Cohort Study 頁： 732 - 737 2011年12月

女性における家族介護者の高血圧自覚の有無による血圧管理状況査読有り

鈴木洋子, 堀容子, 星野純子, 濱本律子, 杉山晃子, 岡田武, 永井邦芳, 近藤高明, 玉腰浩司, 岡本和士, 長澤伸江, 豊嶋英明, 榊原久孝

日本公衆衛生雑誌 58 巻 ( 12 ) 頁： 1016-1025 2011年12月

Early age at menarche associated with increased all-cause mortality 査読有り

TAMAKOSHI Koji, HATSUYA Hiroshi, TAMAKOSHI Akiko

Eur J Epidemiol 2011年10月

Maternal mental disorders and pregnancy outcomes: A clinical study in a Japanese population 査読有り

HIRONAKA Masae, KOTANI Tomomi, SUMIGAMA Seiji, TSUDA Hiroyuki, MANO Yukio, HAYAKAWA Hiromi, TANAKA Satoshi , OZAKI Norio, TAMAKOSHI Koji, KIKKAWA Fumitaka

J Obstet Gynaecol Res 37 巻 ( 10 ) 頁： 1283-1289 2011年10月

Comparison of salivary cortisol, heart rate, and oxygen saturation between early skin-to-skin contact with different initiation and duration times in healthy, full-term infants 査読有り

TAKAHASHI Yuki, TAMAKOSHI Koji, MATSUSHIMA Miyoko, KAWABE Tsutomu

Early Hum Dev 87 巻 ( 3 ) 頁： 151-157 2011年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

PMID:21220191
BACKGROUND: There are few studies that compare the physiological and biological efficacies between different early skin-to-skin contacts (SSC) post birth.

AIM: To investigate physiologically and biochemically how early SSC with different initiation and duration time influence the stress post birth for full-term infants.

STUDY DESIGN: Non-experimental study.

SUBJECTS: Study I; Thirty-two infants who began SSC 5min or less [birth SSC, mean initiation time (standard deviation): 1.6 (1.1) min] after birth and 36 infants who did so more than 5min [very early SSC, 26.3 (5.0) min] in heart rate (HR) and oxygen saturation (SpO(2)) analysis. Study II; Eighteen infants who underwent SSC for 60min or less [mean initiation time: 7.5 (12.2) min] and 61 infants who did so for more than 60min [15.3 (12.5) min] in salivary cortisol analysis.

OUTCOME MEASURES: HR and SpO(2) measured for 30min post birth. Salivary cortisol concentration measured at 1min, 60min, and 120min post birth.

RESULTS: Birth SSC group reached HR stability of 120-160bpm significantly faster than very early SSC group by Kaplan-Meier analysis (P=0.001 by log-rank test). As for SpO(2) stability of 92% and 96%, no significantly between-group difference was found. Salivary cortisol levels were significantly lower between 60 and 120min after birth in SSC group, continuing for more than 60min compared with SSC group for 60min or less after adjustment for salivary cortisol level at 1min besides the infant stress factors (P=0.046).

CONCLUSIONS: Earlier SSC beginning within 5min post birth and longer SSC continuing for more than 60min within 120min post birth are beneficial for stability of cardiopulmonary dynamics and the reduction of infant stress during the early period post birth.

母娘二世代の母子健康手帳にみられる妊娠分娩経過の関連査読有り

田辺圭子，玉腰浩司，室月淳

母性衛生 51 巻 ( 4 ) 頁： 594-600 2011年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）

近年、成人病胎児期起源仮説、Developmental Origin of Health and Disease(DOHaD)仮説が注目されている。今回、母娘二世代362組の母子健康手帳を用いて、二世代間の妊娠分娩経過の関連を検討した。世代間比較では、二世代目は一世代目に比べ身長が高く、妊娠中の平均収縮期血圧が低く、体重増加量が少なく、出生した児の体重が軽かった。また、分娩時出血量が多く、分娩様式では帝王切開を受けた人が多かった。一方、二世代間の非妊娠時体格、妊娠中期以降の血圧や体重増加量、出生児の出生体重と頭囲は統計学的に有意な正の関連を示した。また、重回帰分析による三世代目の出生体重に関連する因子の分析では、二世代目の出生体重が二世代目の非妊娠時のBMIや妊娠時の体重増加量より強く関連することが示された。本研究の結果により、世代間の妊娠分娩経過には、社会背景の変化や医療水準の向上などによる差異はあるものの、関連がみられた。また、前世代の胎内環境が次世代の胎内環境に影響を与えることが示唆された。以上より、前世代の妊娠分娩経過を知ることは、妊娠早期からの保健指導を可能にし、妊娠中の合併症の予防、さらにはその先に続いてゆく世代の健康につながっていく可能性が示唆された。

Association of women's birth weight with their blood pressure during pregnancy and with the body size of their babies 査読有り

TANABE Keiko, TAMAKOSHI Koji, MUROTSUKI Jun

Tohoku J Exp Med 224 巻 ( 4 ) 頁： 287-292 2011年

記述言語：英語掲載種別：研究論文（学術雑誌）

PMID:21791889
The women's own intrauterine environment may influence their own pregnancy and their babies. The aim of our study was to investigate how a woman's birth weight affects the course of her pregnancy later in life as well as the body size of her babies; this study was based on the developmental origins of health and disease (DOHaD) concept. We collected Maternal and Child Health handbooks from 414 women and their biological mothers. They were classified into 3 categories based on the Fetal growth curve of Japan: light-for-date (LFD), which means birth weight is less than the -1.5SD; appropriate-for-date (AFD), which means it lies between the -1.5SD and +1.5SD; and heavy-for-date (HFD), which means it is in the +1.5SD, or higher. In the first trimester, systolic blood pressures (SBPs) were 117.6 (14.4 mmHg), 111.6 (12.4 mmHg), and 105.0 (11.6 mmHg), and diastolic blood pressures (DBP) were 71.0 (8.5 mmHg), 65.7 (9.4 mmHg), and 62.1 (8.7 mmHg) in women born LFD, AFD, and HFD, respectively (SBP: p for trend = 0.018, DBP: p for trend = 0.027). In the second and third trimesters, both SBP and DBP were higher for women born LFD than for those of the other 2 groups. Birth weights of the babies of women born LFD, AFD, and HFD were 2,791.1 (483.0 g), 3,043.4 (361.0 g), and 3,248.0 (431.5 g), respectively (p for trend < 0.01). Our findings support the DOHaD concept and suggest that intrauterine environment in fetal life may be passed down from generation to generation.

Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies. 査読有り

GKRANIA-KLOTSA Effrossyni, YE Zheng, COOPER Andrew J, SHARP Stephen J, LUBEN Robert, BIGGS Mary L, CHEN Liang-Kung, GOKULAKTISHNAN Kuppan, HANEFELD Markolf, INGELSSON Erik, LAI Wen-An, LIN Shih-Yi, LIND Lars, LOHSOONTHORN Vitool, MOHAN Viswanathan, MUSCARI Antonio, NILSSON Goran, OHRVIK John, CHAO QOANG Jiang, LENNY Nancy Swords, TAMAKOSHI Koji, TEMELKOVA-KURKTSCHIEV Theodora, WANG Ya-Yu, YAJNIK Chittaranjan Sakerlal, ZOLI Marco, KHAW Kay-Tee, FOROUHI Nita G, WAREHAM Nicholas J, LANGENBERG Claudia.

PLoS One 18 巻 ( 5 ) 頁： 1-11 2010年10月

Impact of smoking and other lifestyle factors on life expectancy among japanese: findings from the Japan Collaborative Cohort (JACC) Study. 査読有り

TAMAKOSHI Akiko, KAWADO Miyuki, OZASA Kotaro, TAMAKOSHI Koji, LIN Yingsong, YAGYU Kiyoko, KIKUCHI Syogo, HASHIMOTO Suji; JACC Study Group.

J Epidemiol 20 巻 ( 5 ) 頁： 370376 2010年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

PMID: 20631456
BACKGROUND: A number of lifestyle factors, including smoking and drinking, are known to be independently associated with all-cause mortality. However, it might be more effective in motivating the public to adopt a healthier lifestyle if the combined effect of several lifestyle factors on all-cause mortality could be demonstrated in a straightforward manner.

METHODS: We examined the combined effects of 6 healthy lifestyle behaviors on all-cause mortality by estimating life expectancies at 40 and 60 years of age among 62 106 participants in a prospective cohort study with a 14.5-year follow-up. The healthy behaviors selected were current nonsmoking, not heavily drinking, walking 1 hour or more per day, sleeping 6.5 to 7.4 hours per day, eating green leafy vegetables almost daily, and having a BMI between 18.5 to 24.9.

RESULTS: At age 40, we found a 10.3-year increase in life expectancy for men and a 8.3-year increase for women who had all 6 healthy behaviors, as compared with those who had only 0 to 2 healthy behaviors. Increases of 9.6 and 8.2 years were observed for men and women, respectively, at age 60 with all 6 healthy behaviors. When comparing currently nonsmoking individuals with 0 to 1 healthy behaviors, the life expectancy of smokers was shorter in both men and women, even if they maintained all 5 other healthy behaviors.

CONCLUSIONS: Among individuals aged 40 and 60 years, maintaining all 6 healthy lifestyle factors was associated with longer life expectancy. Smokers should be encouraged to quit smoking first and then to maintain or adopt the other 5 lifestyle factors.

Body mass index and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanese cohorts using individual data. 査読有り

YATSUYA Hiroshi, TOYOSHIMA Hideaki, YAMAHISHI Kazymasa, TAMAKOSHI Koji, TAGURI Masataka, HARADA Akiko, OHHASHI Yasuo, KITA Yoshikuni, NAITO Yoshihiko, YAMADA Michiko, TANABE Naohito, ISO Hiroyasu, UESHIMA Hirotsugu; Japan Arteriosclerosis Longitudinal Study (JALS) group.

Circ Cardiovasc Qual Outcomes 3 巻 ( 5 ) 頁： 498-505 2010年9月

Incidence of metabolic syndrome according to combinations of lifestyle factors among middle-aged Japanese male workers. 査読有り

LI Yuanying, YATSUYA Hiroshi, ISO Hiroyasu, TAMAKOSHI Koji, TOYOSHIMA Hideaki.

Prev Med 51 巻 ( 2 ) 頁： 118-122 2010年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

PMID: 20451548
OBJECTIVE: To examine a combination of healthy lifestyles on the risk of metabolic syndrome (MetS) to inform future interventions.

METHODS: A total of 1897 men aged 35-60 years participated in an annual health check-up in 2002 and 2005. MetS was defined by AHA/NCEP criteria. Logistic regression analyses were used to estimate age- and BMI-adjusted odds ratios (ORs) of MetS incidence for each healthy lifestyle (regular physical activity, adherence to healthy eating behaviors, not current smoking, and maintaining a stable weight since one's mid-twenties), separately (Model 1) and simultaneously (Model 2). A points system was developed to derive 3-year risk of MetS incidence by assigning a specific point to each healthy lifestyle.

RESULTS: MetS developed in 285 (15.0%) subjects after the follow-up. The ORs of MetS for each healthy lifestyle ranged from 0.42 to 0.64 (Model 2). Three-year risk of MetS incidence was predicted to differ from 1% to 60% according to the individual point total of the points system. The population-attributable fraction of MetS in subjects whose point total was not in the highest quartile was 71%.

CONCLUSION: Adherence to healthy lifestyles was associated with a lower risk of MetS among apparently healthy middle-aged Japanese male workers.

Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. 査読有り

MURAMATSU Takashi, YATSUYA Hiroshi, TOYOSHIMA Hideaki, SASAKI Satoshi, LI Yuanying, OTSUKA Rei, WADA Keiko, HOTTA Yo, MITSUHASHI Hirotsugu, MATSUSHITA Kunihiro, MUROHARA Toyoaki, TAMAKOSHI Koji.

Prev Med 50 巻 ( 5-6 ) 頁： 272-276 2010年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

PMID: 20211645
OBJECTIVE: To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA+DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake.

METHOD: We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA+DHA intake as the reference were calculated by logistic regression analysis.

RESULTS: Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA+DHA were 47.9 years, 22.9 kg/m(2), and 1.90 g/day (0.88%E) and 0.77 g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1=0.74, P for trend=0.01) and the association was observed only in subjects with a BMI of <25 kg/m(2) (P for interaction=0.033). However EPA+DHA showed no such associations consistently.

CONCLUSION: Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women.

Iron intake and associated factors in general Japanese population: NIPPON DATA80, NIPPON DATA90 and national nutrition monitoring. 査読有り

YURIN Tanvir Chowdhury, OKUDA Nagako, MIURA Katsuyuki, NAKAMURA Yasuyuki, RUMADA Nahid, KADOTA Aya, TAMAKOSHI Koji, UESHIMA Hirotsugu; NIPPON DATA80/90 Research Group.

J Epidemiol Suppl 3 巻頁： 557-566 2010年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

PMID: 20351478
OBJECTIVE: The purpose of this study was to investigate the dietary iron intake and associated other dietary factors and clinical characteristics among a representative sample cohort of Japanese population.

METHODS: We obtained data from NIPPON DATA80 and 90 that were conducted with the National Nutrition Surveys in 1980 and in 1990. Then we estimated nutrient and food intakes of individuals in the National Nutrition Survey of 1980 and that of 1990, which were adjusted on the basis of data of the National Nutrition Survey of 1995. Finally, we analyzed data for the 10,422 participants (4585 men and 5837 women) in NIPPON DATA80 and 8342 participants (3488 men and 4854 women) in NIPPON DATA90 having dietary iron intake information.

RESULTS: In NIPPON DATA80 and 90, there was a significant relationship between the dietary iron intake and age for both men and women. Dietary protein intake was associated with iron intake where as dietary fat intake did not show any association. Regarding the minerals, significant relationships were observed between the different minerals and dietary iron intake. Apart from the food group of milk and dairy products, there were significant differences in other food groups according to quintiles of iron intakes for men and women.

CONCLUSIONS: We described the mean dietary iron intake and its relation with other dietary factors and clinical characteristics in Japanese adults as the baseline data in NIPPON DATA80 and in NIPPON DATA90.

BMI and all-cause mortality among Japanese older adults: findings from the Japan collaborative cohort study. 査読有り

TAMAKOSHI Akiko, YATSUYA Hiroshi, LIN Yingsong, TAMAKOSHI Koji, KONDO Takaaki, SUZUKI Sadao, YAGYU Kiyoko, KIKUCHI Syogo; JACC Study Group.

Obesity (Silver Spring) 18 巻 ( 2 ) 頁： 362-369 2010年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

PMID: 19543206
The association between BMI and all-cause mortality may vary with gender, age, and ethnic groups. However, few prospective cohort studies have reported the relationship in older Asian populations. We evaluated the association between BMI and all-cause mortality in a cohort comprised 26,747 Japanese subjects aged 65-79 years at baseline (1988-1990). The study participants were followed for an average of 11.2 years. Proportional-hazards regression models were used to estimate mortality hazard ratios (HRs) and 95% confidence intervals. Until 2003, 9,256 deaths occurred. The underweight group was associated with a statistically higher risk of all-cause mortality compared with the mid-normal-range group (BMI: 20.0-22.9); resulting in a 1.78-fold (95% confidence interval: 1.45-2.20) and 2.55-fold (2.13-3.05) increase in mortality risk among severest thin men and women (BMI: <16.0), respectively. Even within the normal-range group, the lower normal-range group (BMI: 18.5-19.9) showed a statistically elevated risk. In contrast, being neither overweight (BMI: 25.0-29.9) nor obese (BMI: > or =30.0) elevated the risk among men; however among women, HR was slightly elevated in the obese group but not in the overweight group compared with the mid-normal-range group. Among Japanese older adults, a low BMI was associated with increased risk of all-cause mortality, even among those with a lower normal BMI range. The wide range of BMI between 20.0 and 29.9 in both older men and women showed the lowest all-cause mortality risk.

Changes in activities of daily living, physical fitness, and depressive symptoms after six-month periodic well-rounded exercise programs for older adults living in nursing homes or special nursing facilities. 査読有り

Ouyang P, Yatsuya H, Toyoshima H, Otsuka R, Wada K, Matsushita K, Ishikawa M, Yuanying L, Hotta Y, Mitsuhashi H, Muramatsu T, Kasuga N, Tamakoshi K.

Nagoya J Med Sci 71 巻 ( 3-4 ) 頁： 115-126 2009年9月

Healthy lifestyle and preventable death: findings from the Japan Collaborative Cohort (JACC) Study. 査読有り

Tamakoshi A, Tamakoshi K, Lin Y, Yagyu K, Kikuchi S; JACC Study Group.

Prev Med. 48 巻 ( 5 ) 頁： 486-492 2009年5月

Self-reported medical history was generally accurate among Japanese workplace population. 査読有り

Wada K, Yatsuya H, Ouyang P, Otsuka R, Mitsuhashi H, Takefuji S, Matsushita K, Sugiura K, Hotta Y, Toyoshima H, Tamakoshi K.

J Clin Epidemiol. 62 巻 ( 3 ) 頁： 306-313 2009年3月

Uric acid and left ventricular hypertrophy in Japanese men. 査読有り

Mitsuhashi H, Yatsuya H, Matsushita K, Zhang H, Otsuka R, Muramatsu T, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H, Tamakoshi K.

Circ J. 73 巻 ( 4 ) 頁： 667-672 2009年2月

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