Updated on 2022/04/15

写真a

 
TAMAKOSHI, Koji
 
Organization
Graduate School of Medicine Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Professor

Degree 1

  1. 博士(医学) ( 名古屋大学 ) 

Research Areas 2

  1. Life Science / Obstetrics and gynecology

  2. Life Science / Hygiene and public health (laboratory)

Current Research Project and SDGs 3

  1. Multiple Risk Factor Syndromeの疫学的病態解明

  2. 性差を考慮した生活習慣病発症メカニズムの疫学的病態解明と予防プログラム作成

  3. 胎児期起源仮説に基づく生活習慣病予防―実践に向けてのエビデンス創生―

Education 1

  1. Nagoya University   Faculty of Medicine

    1981.4 - 1987.3

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    Country: Japan

Professional Memberships 5

  1. 日本公衆衛生学会

  2. 日本産科婦人科学会

  3. 日本母性衛生学会

  4. 日本疫学会

  5. 日本循環器予防学会

 

Papers 191

  1. Association between caregivers' health-related quality of life and care recipients' health outcomes

    Hoshino Junko, Tamakoshi Koji, Hori Yoko, Sakakibara Hisataka

    INTERNATIONAL JOURNAL OF NURSING PRACTICE     page: e13044   2022.3

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  2. Hospital organizational structure factors related to discharge planning activities for alcoholics by nurses in Japan

    Adachi Madoka, Tamakoshi Koji, Watai Izumi

    JAPAN JOURNAL OF NURSING SCIENCE     page: e12473   2022.2

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  3. Impact of Body Mass Index on Obesity-Related Cancer and Cardiovascular Disease Mortality; The Japan Collaborative Cohort Study.

    Matsunaga M, Yatsuya H, Iso H, Li Y, Yamagishi K, Tanabe N, Wada Y, Ota A, Tamakoshi K, Tamakoshi A, JACC Study Group.

    Journal of atherosclerosis and thrombosis     2021.12

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    Language:English  

    DOI: 10.5551/jat.63143

    PubMed

  4. Relationships Between Care Recipients' Psychological Symptoms and Family Caregivers' Depressive States

    Hoshino Junko, Tamakoshi Koji, Hori Yoko, Sakakibara Hisataka

    HOME HEALTH CARE MANAGEMENT AND PRACTICE     2021.11

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    Language:Japanese  

    DOI: 10.1177/10848223211058814

    Web of Science

  5. Evaluation of the risk factors for antepartum hemorrhage in cases of placenta previa: a retrospective cohort study

    Kuribayashi Momoko, Tsuda Hiroyuki, Ito Yumiko, Tezuka Atsuko, Ando Tomoko, Tamakoshi Koji, Mizuno Kimio

    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH   Vol. 49 ( 11 ) page: 3000605211054706   2021.11

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  6. Increased afternoon step count increases heart rate variability in patients with cardiovascular risk factors

    Nakayama Natsuki, Miyachi Masahiko, Tamakoshi Koji, Morikawa Shuji, Negi Koji, Watanabe Koji, Moriwaki Yoshimi, Hirai Makoto

    JOURNAL OF CLINICAL NURSING     2021.8

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  7. Decreased continuous sitting time increases heart rate variability in patients with cardiovascular risk factors

    Nakayama Natsuki, Miyachi Masahiko, Tamakoshi Koji, Hayashi Toshio, Negi Koji, Watanabe Koji, Hirai Makoto

    PLOS ONE   Vol. 16 ( 6 ) page: e0253399   2021.6

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  8. Relationship between fasting blood glucose levels in middle age and cognitive function in later life: The Aichi Workers' Cohort Study.

    Shimoda M, Kaneko K, Nakagawa T, Kawano N, Otsuka R, Ota A, Naito H, Matsunaga M, Ichino N, Yamada H, Chiang C, Hirakawa Y, Tamakoshi K, Aoyama A, Yatsuya H

    Journal of epidemiology     2021.5

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    Language:English  

    DOI: 10.2188/jea.JE20210128

    PubMed

  9. The Self of Adolescents with Autism Spectrum Disorder or Attention Deficit Hyperactivity Disorder: A Qualitative Study

    Hanai Fumi, Narama Miho, Tamakoshi Koji

    JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS   Vol. 51 ( 5 ) page: 1668 - 1677   2021.5

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  10. Structure and predictors of in-hospital nursing care leading to reduction in early readmission among patients with schizophrenia in Japan: A cross-sectional study.

    Maki S, Nagai K, Ando S, Tamakoshi K

    PloS one   Vol. 16 ( 4 ) page: e0250771   2021

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    Language:English  

    DOI: 10.1371/journal.pone.0250771

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  11. Positive Association of Physical Activity with Both Objective and Perceived Measures of the Neighborhood Environment among Older Adults: The Aichi Workers' Cohort Study

    Li Yuanying, Yatsuya Hiroshi, Hanibuchi Tomoya, Ota Atsuhiko, Naito Hisao, Otsuka Rei, Murata Chiyoe, Hirakawa Yoshihisa, Chiang Chifa, Uemura Mayu, Tamakoshi Koji, Aoyama Atsuko

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH   Vol. 17 ( 21 )   2020.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijerph17217971

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    PubMed

  12. The effects of nausea, vomiting, and social support on health-related quality of life during early pregnancy: A prospective cohort study

    Hirose Masami, Tamakoshi Koji, Takahashi Yuki, Mizuno Taeko, Yamada Akiko, Kato Noriko

    JOURNAL OF PSYCHOSOMATIC RESEARCH   Vol. 136   page: 110168   2020.9

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  13. Risk and population attributable fraction of metabolic syndrome and impaired fasting glucose for the incidence of type 2 diabetes mellitus among middle-aged Japanese individuals: Aichi Worker's Cohort Study

    Kaneko Kayo, Yatsuya Hiroshi, Li Yuanying, Uemura Mayu, Chiang Chifa, Hirakawa Yoshihisa, Ota Atsuhiko, Tamakoshi Koji, Aoyama Atsuko

    JOURNAL OF DIABETES INVESTIGATION   Vol. 11 ( 5 ) page: 1163 - 1169   2020.9

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  14. Increased Activity in Patients with Cardiovascular Risk Factors Increases Heart Rate Variability

    Nakayama Natsuki, Miyachi Masahiko, Tamakoshi Koji, Negi Koji, Watanabe Koji, Hirai Makoto

    WESTERN JOURNAL OF NURSING RESEARCH   Vol. 42 ( 6 ) page: 431 - 436   2020.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0193945919864700

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    PubMed

  15. The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study

    Yamamoto Eiko, Tien Dat Minh, Sekiya Yoko, Tamakoshi Koji, Xuan Phuoc Nguyen, Nishino Kimihiro, Kotani Kaoru Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Quang Thanh Le, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 183 - 191   2020.5

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  16. Relationship of household salt intake level with long-term all-cause and cardiovascular disease mortality in Japan: NIPPON DATA80

    Shima Azusa, Miyamatsu Naomi, Miura Katsuyuki, Miyagawa Naoko, Okuda Nagako, Yoshita Katsushi, Kadota Aya, Suzuki Harumitsu, Kondo Keiko, Okamura Tomonori, Okayama Akira, Ueshima Hirotsugu, Saitoh Shigeyuki, Sakata Kiyomi, Hozawa Atsushi, Hayakawa Takehito, Nakamura Yosikazu, Nishi Nobuo, Ohkubo Takayoshi, Kasagi Fumiyoshi, Murakami Yoshitaka, Izumi Toru, Matsumura Yasuhiro, Ojima Toshiyuki, Tamakoshi Koji, Nakagawa Hideaki, Kita Yoshikuni, Fujiyoshi Akira, Nakamura Yasuyuki, Miyamoto Yoshihiro, Kodama Kazunori, Kiyohara Yutaka

    HYPERTENSION RESEARCH   Vol. 43 ( 2 ) page: 132 - 139   2020.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-019-0349-9

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  17. Television Viewing Time and Breast Cancer Incidence or Japanese Premenopausal and Postmenopausal Women: The JACC Study

    Cao Jinhong, Eshak Ehab Salah, Liu Keyang, Muraki Isar, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo, Kurozawa Yoichi

    CANCER RESEARCH AND TREATMENT   Vol. 51 ( 4 ) page: 1509 - 1517   2019.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.4143/crt.2018.705

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  18. Cardiovascular Risk Assessment Chart by Dietary Factors in Japan - NIPPON DATA80-

    Kondo Keiko, Miura Katsuyuki, Tanaka-Mizuno Sachiko, Kadota Aya, Arima Hisatomi, Okuda Nagako, Fujiyoshi Akira, Miyagawa Naoko, Yoshita Katsushi, Okamura Tomonori, Okayama Akira, Ueshima Hirotsugu, Ueshima Hirotsugu, Okayama Akira, Ueshima Hirotsugu, Okamura Tomonori, Saitoh Shigeyuki, Sakata Kiyomi, Hozawa Atsushi, Hayakawa Takehito, Nakamura Yosikazu, Nishi Nobuo, Okuda Nagako, Ohkubo Takayoshi, Kasagi Fumiyoshi, Murakami Yoshitaka, Izumi Toru, Matsumura Yasuhiro, Ojima Toshiyuki, Tamakoshi Koji, Nakagawa Hideaki, Kita Yoshikuni, Miura Katsuyuki, Kadota Aya, Fujiyoshi Akira, Miyamatsu Naomi, Nakamura Yasuyuki, Yoshita Katsushi, Miyamoto Yoshihiro, Kodama Kazunori, Kiyohara Yutaka

    CIRCULATION JOURNAL   Vol. 83 ( 6 ) page: 1254 - +   2019.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-18-1002

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  19. Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke: Findings From the Japan Collaborative Cohort Study

    Ukawa Shigekazu, Zhao Wenjing, Yatsuya Hiroshi, Yamagishi Kazumasa, Tanabe Naohito, Iso Hiroyasu, Tamakoshi Akiko, Mori Mitsuru, Sakauchi Fumio, Motohashi Yutaka, Tsuji Ichiro, Nakamura Yosikazu, Iso Hiroyasu, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Miki Tsuneharu, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo

    JOURNAL OF EPIDEMIOLOGY   Vol. 29 ( 6 ) page: 233 - 237   2019.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20170341

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  20. Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly: NIPPON DATA 80, 90, and 2010

    Shibata Yosuke, Ojima Toshiyuki, Nakamura Mieko, Kuwabara Kazuyo, Miyagawa Naoko, Saito Yoshino, Nakamura Yasuyuki, Kiyohara Yutaka, Nakagawa Hideaki, Fujiyoshi Akira, Kadota Aya, Ohkubo Takayoshi, Okamura Tomonori, Ueshima Hirotsugu, Okayama Akira, Miura Katsuyuki, Ueshima Hirotsugu, Miura Katsuyuki, Okayama Akira, Okamura Tomonori, Okayama Akira, Okamura Tomonori, Ueshima Hirotsugu, Okayama Akira, Okamura Tomonori, Saitoh Shigeyuki, Sakata Kiyomi, Hozawa Atsushi, Hayakawa Takehito, Nakamura Yosikazu, Nishi Nobuo, Okuda Nagako, Okamura Tomonori, Murakami Yoshitaka, Ohkubo Takayoshi, Kasagi Fumiyoshi, Izumi Toru, Matsumura Yasuhiro, Ojima Toshiyuki, Tamakoshi Koji, Nakagawa Hideaki, Kita Yoshikuni, Miura Katsuyuki, Kadota Aya, Miyamatsu Naomi, Nakamura Yasuyuki, Yoshita Katsushi, Miyamoto Yoshihiro, Kodama Kazunori, Kiyohara Yutaka

    JOURNAL OF EPIDEMIOLOGY   Vol. 29 ( 4 ) page: 133 - 138   2019.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20170229

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  21. Sleep duration and risk of breast cancer: The JACC Study

    Cao Jinhong, Eshak Ehab S., Liu Keyang, Muraki Isao, Cui Renzhe, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo

    BREAST CANCER RESEARCH AND TREATMENT   Vol. 174 ( 1 ) page: 219-225   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10549-018-4995-4

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  22. Television viewing time, walking time, and risk of type 2 diabetes in Japanese men and women: The Japan Collaborative Cohort Study

    Ikehara Satoyo, Iso Hiroyasu, Maruyama Koutatsu, Ukawa Shigekazu, Tamakoshi Akiko, Aoki Kunio, Ohno Yoshiyuki, Sugano Haruo, Tajima Kazao, Mori Mitsuru, Sakauchi Fumio, Motohashi Yutaka, Tsuji Ichiro, Nakamura Yoshikazu, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Hashimoto Shuji, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Miki Tsuneharu, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Yoshimura Takesumi, Fujino Yoshihisa, Shibata Akira, Okamoto Naoyuki, Shio Hideo

    PREVENTIVE MEDICINE   Vol. 118   page: 220-225   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ypmed.2018.11.006

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  23. Time-Related Changes in Relationships Between the Keys Score, Dietary Lipids, and Serum Total Cholesterol in Japan - NIPPON DATA80/90/2010-

    Okami Yukiko, Ueshima Hirotsugu, Nakamura Yasuyuki, Kondo Keiko, Kadota Aya, Okuda Nagako, Okamura Tomonori, Miura Katsuyuki, Fujiyoshi Akira, Hozawa Atsushi, Kadota Aya, Kasagi Fumiyoshi, Nakagawa Hideaki, Toyoshima Hideaki, Yanagawa Hiroshi, Yoshita Katsushi, Kodama Kazunori, Ueda Kazuo, Sakata Kiyomi, Tamakoshi Koji, Okuda Nagako, Miyamatsu Naomi, Nishi Nobuo, Saitoh Shigeyuki, Tokudome Shinkan, Okubo Takayoshi, Hayakawa Takehito, Izumi Toru, Ojima Toshiyuki, Matsumura Yasuhiro, Miyamoto Yoshihiro, Kita Yoshikuni, Murakami Yoshitaka, Nakamura Yoshikazu, Kiyohara Yutaka

    CIRCULATION JOURNAL   Vol. 83 ( 1 ) page: 147-+   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-18-0628

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  24. Smoking results in accumulation of ectopic fat in the liver

    Kato Ayako, Li Yuanying, Ota Atsuhiko, Naito Hisao, Yamada Hiroya, Nihashi Takashi, Hotta Yo, Chiang Chifa, Hirakawa Yoshihisa, Aoyama Atsuko, Tamakoshi Koji, Yatsuya Hiroshi

    DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY   Vol. 12   page: 1075-1079   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2147/DMSO.S21495

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  25. Self-Reported Eczema in Relation with Mortality from Cardiovascular Disease in Japanese: the Japan Collaborative Cohort Study

    Nishida Yoko, Kubota Yasuhiko, Iso Hiroyasu, Tamakoshi Akiko, Tamakoshi Akiko, Mori Mitsuru, Kaneko Yoshihiro, Tsuji Ichiro, Nakamura Yosikazu, Iso Hiroyasu, Yamagishi Kazumasa, Mikami Haruo, Kurosawa Michiko, Hoshiyama Yoshiharu, Tanabe Naohito, Tamakoshi Koji, Wakai Kenji, Ando Masahiko, Suzuki Koji, Hashimoto Shuji, Yatsuya Hiroshi, Kikuchi Shogo, Wada Yasuhiko, Kawamura Takashi, Watanabe Yoshiyuki, Ozasa Kotaro, Mikami Kazuya, Date Chigusa, Sakata Kiyomi, Kurozawa Yoichi, Fujino Yoshihisa, Shibata Akira

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   Vol. 26 ( 9 ) page: 775 - 782   2019

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.46383

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  26. Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders

    Matsukawa Satoshi, Sumigama Seiji, Kotani Tomomi, Wang Jingwen, Miki Rika, Moriyama Yoshinori, Nakano Tomoko, Mano Yukio, Tsuda Hiroyuki, Tamakoshi Koji, Kikkawa Fumitaka

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 84 ( 4 ) page: 396 - 406   2019

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000496609

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  27. Association of gamma-glutamyl transferase and alanine aminotransferase with type 2 diabetes mellitus incidence in middle-aged Japanese men: 12-year follow up.

        2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.12930

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  28. The association between objective measures of residence and worksite neighborhood environment, and self-reported leisure-time physical activities: The Aichi Workers' Cohort Study.

    Li Y, Yatsuya H, Hanibuchi T, Hirakawa Y, Ota A, Uemura M, Chiang C, Otsuka R, Murata C, Tamakoshi K, Toyoshima H, Aoyama A

    Preventive medicine reports   Vol. 11   page: 282-289   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pmedr.2018.07.007

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  29. Relationship between the mode of conception and depressive symptoms during the first 6months post-partum in Japan

    Mori Emi, Iwata Hiroko, Maehara Kunie, Sakajo Akiko, Tamakoshi Koji

    REPRODUCTIVE MEDICINE AND BIOLOGY   Vol. 17 ( 3 ) page: 275 - 282   2018.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/rmb2.12101

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  30. Shoulder stiffness, back pain, and wrist pain: Are older primiparas more vulnerable?

    Iwata Hiroko, Mori Emi, Maehara Kunie, Sakajo Akiko, Aoki Kyoko, Tamakoshi Koji

    INTERNATIONAL JOURNAL OF NURSING PRACTICE   Vol. 24   page: e12654   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ijn.12654

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  31. Course of maternal fatigue and its associated factors during the first 6 months postpartum: a prospective cohort study

    Iwata Hiroko, Mori Emi, Sakajo Akiko, Aoki Kyoko, Maehara Kunie, Tamakoshi Koji

    NURSING OPEN   Vol. 5 ( 2 ) page: 186-196   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/nop2.130

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  32. A Point System for Predicting 10-Year Risk of Developing Type 2 Diabetes Mellitus in Japanese Men: Aichi Workers' Cohort Study.

    Yatsuya H, Li Y, Hirakawa Y, Ota A, Matsunaga M, Haregot HE, Chiang C, Zhang Y, Tamakoshi K, Toyoshima H, Aoyama A

    Journal of epidemiology     2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20170048

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  33. Association between the perspective of adult inpatients with digestive cancer regarding the nursing service and their quality of recovery on postoperative day 3

    Sasaki Kumiko, Tamakoshi Koji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 1 ) page: 29-37   2018.2

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    DOI: 10.18999/nagjms.80.1.29

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  34. The Positive Association Between Duration of Skin-to-Skin Contact and Blood Glucose Level in Full-Term Infants.

    Takahashi Y, Tamakoshi K

    The Journal of perinatal & neonatal nursing   Vol. 32 ( 4 ) page: 351 - 357   2018

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/JPN.0000000000000335

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  35. [The relationship between parenting anxiety in mothers and the resources from which they routinely sought advice: The final "Healthy Parents and Children 21" survey].

    Yamazaki S, Shinohara R, Akiyama Y, Ichikawa K, Ojima T, Tamakoshi K, Matsuura K, Yamazaki Y, Yamagata Z

    [Nihon koshu eisei zasshi] Japanese journal of public health   Vol. 65 ( 7 ) page: 334-346   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.11236/jph.65.7_334

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  36. Obstetric factors associated with salivary cortisol levels of healthy full-term infants immediately after birth

    Takahashi Y., Matsushima M., Nishida T., Tanabe K., Kawabe T., Tamakoshi K.

    CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY   Vol. 45 ( 6 ) page: 828-832   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.12891/ceog4088.2018

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  37. Association of serum asymmetric dimethylarginine, homocysteine, and l-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy. Reviewed

    MURATE ei, WANG Jingwen, KOTANI Tomomi, TSUDA Hiroyuki, NAKANO Tomoko, IMAI Kenji, SUMIGAMA Seiji, NIWA Yoshimitsu, MITSUI Takashi, YOSHIDA Shigeru, YAMASHITA Mamoru, NAWA Akihiro, TAMAKOSHI Koji, KAJIYAMA Hiroaki, KIKKAWA Fumitaka

    Clinica Chimica Acta   Vol. 475   page: 70-77   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cca.2017.10.007

  38. Anxiety during pregnancy and autonomic nervous system activity: A longitudinal observational and cross-sectional study. Reviewed

    MIZUNO Taeko, TAMAKOSHI Koji, TANABE Keiko

    J Psychosom Res   Vol. 99   page: 105-111   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jpsychores.2017.06.006.

  39. Palliative care and nursing support for patients experiencing dyspnoea. Reviewed

    SUGIMURA Ayumi, ANDO Shoko, TAMAKOSHI Koji

    Int J Palliat Nurs   Vol. 23 ( 7 ) page: 342-351   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.12968/ijpn.2017.23.7.342

  40. Similarities and differences between coronary heart disease and stroke in the associations with cardiovascular risk factors: The Japan Collaborative Cohort Study. Reviewed

    MATSUNAGA Masaaki, YATSUYA Hiroshi, ISO Hiroyasu, YAMASHITA Kentaro, LI Yuanying, YAMAGISHI Kaxumasa, TANABE Naohiro, WADA Yasuhiko, WANG Chaochen, OTA Atsuhiko, TAMAKOSHI Koji, TAMAKOSHI Akiko

    Atherosclerosis   Vol. 261   page: 124-130   2017.6

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    DOI: 10.1016/j.atherosclerosis.2017.03.003

  41. Association between physical and depressive symptoms during the first 6 months postpartum. Invited Reviewed

    MORI Emi, IWATA Hiroko, SAKAJO Akiko, MAEAGARA Kunie, TAMAKOSHI Koji

    Int J Nurs Pract   Vol. 23 ( Suppl 1 )   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ijn.12545

  42. Similarities and differences between coronary heart disease and stroke in the associations with cardiovascular risk factors: The Japan Collaborative Cohort Study

    Matsunaga Masaaki, Yatsuya Hiroshi, Iso Hiroyasu, Yamashita Kentaro, Li Yuanying, Yamagishi Kazumasa, Tanabe Naohito, Wada Yasuhiko, Wang Chaochen, Ota Atsuhiko, Tamakoshi Koji, Tamakoshi Akiko

    ATHEROSCLEROSIS   Vol. 261   page: 124-130   2017.6

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    DOI: 10.1016/j.atherosclerosis.2017.03.003

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  43. Association between physical and depressive symptoms during the first 6months postpartum

    Mori Emi, Iwata Hiroko, Sakajo Akiko, Maehara Kunie, Tamakoshi Koji

    INTERNATIONAL JOURNAL OF NURSING PRACTICE   Vol. 23   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ijn.12545

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  44. Long-term weight-change slope, weight fluctuation and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: findings of Aichi Workers' Cohort Study. Reviewed

    ZHANG Yan, YATSUYA Hiroshi, LI Yuanying, CHIANG Chifa, HIRAKAWA Yoshihisa, TAMAKOSHI Koji, TOYOSHIMA Hideaki, AOYAMA Atsuko

    Nutr Diabetes   Vol. 7 ( 3 ) page: e252   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nutd.2017.5.

  45. The relationship between three signs of fetal magnetic resonance imaging and severity of congenital diaphragmatic hernia. Reviewed

    HATTORI T, HAYAKAWA M, ITO M, SATO Y, TAMAKOSHI K, KANAMORI Y, OKUYAMA H, INAMURA N, TAKAHASHI S, FUJINO Y, TAGUCHI T, USUI N

    J Perinatol   Vol. 37 ( 3 ) page: 265-269   2017.3

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  46. Fatigue, depression, maternal confidence, and maternal satisfaction during the first month postpartum: A comparison of Japanese mothers by age and parity. Reviewed

    MORI Emi, TSUCHIYA Miyako, MAEHARA Kunie, IWATA Hiroko, SAKAJO Akiko, TAMAKOSHI Koji

    Int J Nurs Pract   Vol. 23 ( 1 )   2017.2

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    DOI: 10.1111/ijn.12508

  47. Perinatal outcomes of abnormal umbilical coiling according to a modified umbilical coiling index. Reviewed

    OHNO Yauamasa, TERAUCHI Mikio, TAMAKOSHI Koji

    J Obstet Gynaecol Res.   Vol. 42 ( 11 ) page: 1457-1463   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.13092

  48. Prevalence of postpartum depressive symptoms during the first 6 months postpartum: Association with maternal age and parity. Reviewed

    IWATA Hiroko, MORI Emi, SAKAJO Akiko, AOKI Kyoko, MAEHARA Kunie, TAMAKOSHI Koji

    J Affect Disord.   Vol. 203   page: 227-232   2016.10

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    DOI: 10.1016/j.jad.2016.06.002

    PubMed

  49. Factors affecting maternal confidence among older and younger Japanese primiparae at one month post-partum. Reviewed

    MAEHARA Kunie, MORI Emi, TSUCHIYA Miyako, IWATA Hiroko, SAKAJO Akiko, OZAWA Harumi, MORITA Akiko, MAEKAWA Tomoko, MAKAYA Miyuki, TAMAKOSHI Koji

    Jpn J Nurs Sci   Vol. 13 ( 4 ) page: 424-436   2016.10

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    DOI: 10.1111/jjns.12123

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  50. Perinatal outcomes of abnormal umbilical coiling according to a modified umbilical coiling index. Reviewed

    OHNO Yasumasa, TERAUCHI Mikio, TAMAKOSHI Koji

    J Obstet Gynaecol Res     2016.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.13092

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  51. Caregiving activities closely associated with the development of low-back pain among female family caregivers. Reviewed

    SUZUKI Kishiko, TAMAKOSHI Koji, SAKAKIBARA Hisataka

    J Clin Nurs   Vol. 25 ( 16-16 ) page: 2156-2167   2016.8

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    DOI: 10.1111/jocn.13167

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  52. Comparison of prognoses according to non-positive and positive spectrin αII expression detected immunohistochemically in epithelial ovarian carcinoma: a retrospective study. Reviewed

    MAEDA Osamu, MIYATA-TAKATA Tomoko, SHIBATA Kiyosumi, KAJIYAMA Hiroaki, MIZUNO Mika, TAMAKOSHI Koji, SHIMOYAMA Yoshie, NAKAMURA Shigeo, KIKKAWA Fumitaka

    Cancer Med   Vol. 5 ( 6 ) page: 1081-1092   2016.6

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    DOI: 10.1002/cam4.683

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  53. Prospective study of seaweed consumption and thyroid cancer incidence in women: the Japan collaborative cohort study. Reviewed

    WANG Chaochen, YATSUYA Hiroshi, LI Yuanying, OTA Atsuhiko,TAMAKOSHI Koji, FUJINO Yoshihisa, MIKAMI Haruo, ISO Hiroyasu, TAMAKOSHI Akiko

    Eur J Cancer Prev   Vol. 25 ( 3 ) page: 239-245   2016.5

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    DOI: 10.1097/CEJ.0000000000000168

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  54. Factors affecting maternal confidence and satisfaction in older Japanese primiparae during postpartum hospital stay. Reviewed

    MAEHARA Kunie, MORI Emi, TSUCHIYA Miyako, IWATA Hiroko, SAKAJO Akiko, TAMAKOSHI Koji

    Int J Nurs Prac   Vol. 22 ( Suppl 1 ) page: 14-21   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ijn.12435

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  55. Cross-sectional and longitudinal validation of a 13-item fatigue scale among Japanese postpartum mothers. Reviewed

    Tsuchiya M, Mori E, Sakajo A, Iwata H, Maehara K, Tamakoshi K.

    Int J Nurs Pract   Vol. 22 ( Suppl 1 ) page: 5-13   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ijn.12434

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  56. The risk factors for labor onset hypertension Reviewed

    OHONO Yasumasa, TERAUCHI Mikio, TAMAKOSHI Koji, SHIOZAKI Arihiro, SAITO Shigeru

    Hypertens Res   Vol. 39 ( 4 ) page: 260-265   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/hr.2015.112

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  57. Impact of chorioamnionitis on short- and long-term outcomes in very low birth weight preterm infants: the Neonatal Research Network Japan. Reviewed

    MIYAZAKI Ken, FURUHASHI Madoka, ISHIAKAWA Kaoru, TAMAKOSHI Koji, HAYASHI Kazutoshi, KAI Akihiro, ISHIKAWA Hiroshi, MURABAYASHI Nao, KEDA Tomoaki, KONO Yumi, KUSADA Satoshi, FUJIMURA Masanori

    J Matern Fetal Neonatal Med.   Vol. 29 ( 2 ) page: 331-337   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00404-013-3106-3

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  58. Predictors of depressive symptoms in older Japanese primiparas at 1 month post-partum: A risk-stratified analysis. Reviewed

    IWATA Hiroko, MORI Emi, TSUCHIYA Miyako, SAKAJO Akiko, MAEHARA Kunie, OZAWA Harumi, MORITA Akiko, MAEKAWA Tomoko, AOKI Kyoko, TAMAKOSHI Koji

    Jpn J Nurs Sci   Vol. 13 ( 1 ) page: 147-155   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jjns.12099

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  59. Age-specific determinants of post-partum fatigue in primiparous women. Reviewed

    TSUCHIYA Miyako, MORI Emi,, SAKAJO Akiko,MAEKAWA Tomoko, IWATA Hiroko, MAEHARA Kunie, MORITA Akiko, OZAWA Harumi, MOCHUZUKI Yoshimi, AOKI Kyoko, MAKAYA Miyuki, TAMAKOSHI Koji

    Jpn J Nurs Sci   Vol. 13 ( 1 ) page: 93-94   2016.1

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    DOI: 10.1111/jjns.12089

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  60. Weight Gain and Alcohol Drinking Associations with Breast Cancer Risk in Japanese Postmenopausal Women - Results from the Japan Collaborative Cohort (JACC) Study. Reviewed

    NITTA Junichi, NOJIMA Masanori, OHNISHI Hirofumi, MORI Mitsuru, WAKAI Kenji, SUZUKI Sadao, FUJINO Yoshihisa, LIN Yingsong, TAMAKOSHI Koji, TAMAKOSHI Akiko

    Asian Pac J Cancer Prev   Vol. 17 ( 3 ) page: 1437-1443   2016

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    PubMed

  61. Long-term outcomes of antenatal corticosteroids treatment in very preterm infants after chorioamnionitis. Reviewed

    MIYAZAKI Ken, FURUHASHI Madoka, ISHIAKAWA Kaoru, TAMAKOSHI Koji, HAYASHI Kazutoshi, KAI Akihiro, ISHIKAWA Hiroshi, MURABAYASHI Nao, KEDA Tomoaki, KONO Yumi, KUSADA Satoshi, FUJIMURA Masanori

    Arch Gynecol Obstet   Vol. 292 ( 6 ) page: 1239-1246   2015.12

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    DOI: 10.1007/s00404-015-3762-6

    PubMed

  62. Predicting early post-partum depressive symptoms among older primiparous Japanese mothers. Reviewed

    IWATA Hiroko, MORI Emi, TSUCHIYA Miyako, SAKAJO Akiko, MAEHARA Kunie, OZAWA Harumi, MORITA Akiko, MAEKAWA Tomoko, AOKI Kyoko, MAKAYA Miyuki, TAMAKOSHI Koji

    Japanese Journal of Nursing Science   Vol. 12 ( 4 ) page: 297-308   2015.10

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    DOI: 10.1111/jjns.12069

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  63. Association between parental history of diabetes and the incidence of type 2 diabetes mellitus differs according to the sex of the parent and offspring's body weight: A finding from a Japanese worksite-based cohort study. Reviewed

    WANG Chaochen, YATSUYA Hiroshi, TAMAKOSHI Koji, TOYOSHIMAHideaki, WADA Keiko, LI Yuanying, HILAWE Esayas Haregot, UEMURA Mayu, CHIANG Chifa, ZHANG Yan, OTSUKA Rei, OTA Atsuhiko, HIRAKAWA Yoshihisa, AOYAMA Atsuko

    Prev Med.     2015.8

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    DOI: 10.1016/j.ypmed.2015.07.021

  64. Breakfast Skipping is Positively Associated With Incidence of Type 2 Diabetes Mellitus: Evidence From the Aichi Workers' Cohort Study. Reviewed

    UEMURA Mayu, YATSUYA Hiroshi, HILAWEI Esayas Haregot, LI Yuanying, WANG Chaochen, CHIANG Chifa, OTSUKA Rei, TOYOSHIMA Hideaki, TAMAKOSHI Koji, AOYAMA Atsuko

    J Epidemiol.   Vol. 25 ( 5 ) page: 351-358   2015.5

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  65. Smoking and diabetes: is the association mediated by adiponectin, leptin, or C-reactive protein? Reviewed

    HILAWE Esayas Haregot, Hiroshi Yatsuya, Yuanying Li, UEMURA Mayu, WANG Chaochen, CHIANG Chifa, TOYOSHIMA Hideaki, TAMAKOSHI Koji, ZHANG Yan, KAWAZOE Nobuo, AOYAMA Atsuko

    J Epidemiol   Vol. 25 ( 2 ) page: 99-109   2015.2

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    DOI: 10.2188/jea.JE20140055

  66. Milk drinking and mortality: findings from the Japan collaborative cohort study. Reviewed

    WANG Chaochen, YATSUYA Hiroshi, TAMAKOSHI Koji, ISO Hiroyasu, TAMAKOSHI Akiko

    J Epidemiol   Vol. 25 ( 1 ) page: 66-73   2015.1

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    DOI: 10.2188/jea.JE20140081

  67. Is the serum l-arginine level during early pregnancy a predictor of pregnancy-induced hypertension? Reviewed

    WANG Jingwen, KOTANI Tomomi, TSUDA Hiroyuki, MANO Yukio, SUMIGAMA Seiji, LI Hua, KOMATSU Koji, MIKI Rika, MARUTA Ei, NIWA Yoshimitsu, MITSUI Takashi, YOSHIDA Shigeru, TAMASHITA Mamoru, TAMAKOSHI Koji, KIKKAWA Fumitaka

    J Clin Biochem Nutr.   Vol. 57 ( 1 ) page: 74-81   2015.1

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    DOI: 10.3164/jcbn.14-104

  68. Independent association of liver fat accumulation with insulin resistance. Reviewed

    YATSUYA Hiroshi, NIHASHI Takashi, LI Yuanying, HOTTA You, MATSUSHITA Kunihiro, MURAMATSU Takashi, OTSUKA Rei, MATSUNAGA Masaaki, YAMASHITA Kentaro, WANG Chaochen, UEMURA Mayu, HARADA Akiko, FAKATSU Hiroshi, TOYOSHIMA Hideaki, AOYAMA Atsuko, TAMAKOSHI Koji

    Obes Res Clin Pract   Vol. 8 ( 4 ) page: 350-355   2014.7

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    DOI: 10.1016/j.orcp.2013.08.002

  69. The effects of antenatal corticosteroids therapy on very preterm infants after chorioamnionitis. Reviewed

    MIYAZAKI Ken, FURUHASHI Madoka, ISHIAKAWA Kaoru, TAMAKOSHI Koji, IKEDA Tomoaki

    Arch Gynecol Obstet   Vol. 286 ( 6 ) page: 1185-1190   2014.7

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    DOI: 10.1007/s00404-013-3106-3

  70. The levels of the neutrophil elastase in the amniotic fluid of pregnant women whose infants develop bronchopulmonary dysplasia.

    IKEDA Sayako, KIHIRA Kana, TOKOI Akira, TAMAKOSHI Koji, MIYAZAKI Ken, FURUHASGI Madoka

    J Matern Fatal Neonatal Med     page: 1-5   2014.6

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  71. Uterine sutures at prior caesarean section and placenta accreta in subsequent pregnancy: a case-control study. Reviewed

    SUMIGAMA Seiji, SUGIYAMA Chisato, KOTANI Tomomi, HAYAKAWA Hiromi, INOUE AKIKO, MANO Yukio, TSUDA Hiroyuki, FURUHASHI Madoka, YAMAMURO Osamu, KINOSHIATA Yoshito, OKAMOTO Tomomitsu, NAKAMURA Hiromi, MATSUSAWA Katsuji, SAKAKIBARA Katsumi, OGUCHI Hidenori, KAWAi Michiyasu, SHIMOYAMA Yoshie, TAMAKOSHI Koji, KIKKAWA Fumitaka

    British Journal of Obstetrics and Gynaecology   Vol. 121 ( 7 ) page: 866-74   2014.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1471-0528.12717

  72. Descriptive epidemiological study of food intake among Japanese adults: analyses by age, time and birth cohort model. Reviewed

    OTSUKA Rei, YATSUYA Hiroshi, TAMAKOSHI Koji

    BMI Public Health   Vol. 14   page: 328   2014.4

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    DOI: 10.1186/1471-2458-14-328

  73. Body mass index-modified relationship of chronic mental stress with resting blood pressure during 5 years in Japanese middle-aged male workers. Reviewed

    TOYOSHIMA hideaki, OTSUKA Rei, HASHIMOTO Shuji, RAMAKOSHI Koji, YATSUYA Hiroshi

    Circulation Journal   Vol. 78 ( 6 ) page: 1379-1386   2014.4

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    DOI: org/10.1253/circj.CJ-13-1086

  74. Factors associated with early postpartum maternity blues and depression tendency among Japanese mothers with full-term healthy infants. Reviewed

    TAKAHASHI Yuki, TAMAKOSHI Koji

    Nagoya J Med Sci   Vol. 76 ( 1-2 ) page: 129-138   2014.2

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  75. Learning disability in 10- to 16-year-old adolescents with very low birth weight in Japan. Reviewed

    TANABE Keiko, TAMAKOSHI Koji, KIKUCHI Saya, MUROTSUKI Jun

    Tohoku J Exp Med.   Vol. 232 ( 1 ) page: 27-33   2014.1

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  76. Positive association between high-sensitivity C-reactive protein and incidence of type 2 diabetes mellitus in Japanese workers: 6-year follow-up Reviewed

    WANG Chaochen, YATSUYA Hiroshi, TAMAKOSHI Koji, UEMURA Mayu, LI Yuanying, WADA Keiko, YAMASHITA Kentaro, KAWAGUCHU Leo, TOYOSHIMA Hideaki, AOYAMA Atsuko

    Diabetes Metab Res Rev   Vol. 29 ( 5 ) page: 398-405   2013.7

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    DOI: 10.1002/dmrr.2406

  77. Ovarian cancer mortality among women aged 40-79 years in relation to reproductive factors and body mass index: latest evidence from the Japan Collaborative Cohort study Reviewed

    KHAN Md. Mobarak Hossain, KHAN Aklimunnessa, NOJIMA Masahiro, SUZUKI Sadao, FUJINO Yoshihisa, TOKUDOME Shinkan, TAMAKOSHI Koji, MORI Mitsuru, TAMAKOSHI Akiko

    J Gynecol Oncol   Vol. 24 ( 3 ) page: 249-257   2013.7

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    DOI: 10.3802/jgo.2013.24.3.249

  78. Obesity/weight gain and breast cancer risk: findings from the Japan collaborative cohort study for the evaluation of cancer risk. Reviewed

    SUZUKI Sadao, KOJIMA Masayo, TOKUDOME Shinkan, MORI Mitsuru, SAKAUCHI Fumio, WAKAI Kenji, FUJINO Yoshihisa, LIN Yingsong, KIKUCHI Shogo, TAMAKOSHI Koji, TAMAKOSHI Akiko

    J Epidemiol   Vol. 23 ( 2 ) page: 139-145   2013.2

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  79. Associations of protein, fat, and carbohydrate intakes with insomnia symptoms among middle-aged Japanese workers. Reviewed

    TANAKA Eizaburo, YATSUYA Hiroshi, UEMURA Mayu, OTSUKA Rei, TOYOSHIMA Hideaki, TAMAKOSHI Koji, SASAKI Satoshi, KAWAGUCHI Leo, AOYAMA Atsuko

    J Epidemiol   Vol. 23 ( 2 ) page: 132-138   2013.2

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  80. Multiple roles and all-cause mortality: the Japan Collaborative Cohort Study Reviewed

    TAMAKOSHI Akiko, IKEDA Ai, FUJINO Yoshihisa, TAMAKOSHI Koji, ISO Hiroyasu

    Eur J Public Health     2013.2

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    DOI: 10.1093/eurpub/ckr194

  81. Characteristics of hypertension-related factors in female home caregivers in Japan-comparison with general community non-caregivers. Reviewed

    HOSHINO Junko, HORI Yoko, KONDO Takaaki, TAMAKOSHI Koji, TOYOSHIMA Hideaki, SAKAKIBARA Hisataka

    J Clin Nurs     2013.2

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    Access below to see full text; http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2702.2011.04039.x/full
    PMID:22642659

    DOI: DOI: 10.1111/j.1365-2702.2011.04039.x

  82. Validation of the prediction model for success of vaginal birth after cesarean delivery in Japanese women. Reviewed

    YOKOI Akira, ISHIKAWA Kaoru, MIYAZAKI Ken, TOSHIDA Kana, FYRUHASHI Madoka, TAMAKOSHI Koji

    Int J Med Sci   Vol. 9 ( 6 ) page: 488-491   2012.8

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    Access below to see full text; http://www.medsci.org/v09p0488.htm
    PMID:22927774

    DOI: doi:10.7150/ijms.4682

  83. Inverse relationship of serum adiponectin concentration with type 2 diabetes mellitus incidence in middle-aged Japanese workers: six-year follow-up. Reviewed

    LI Yuanying, YATSUYA Hiroshi, ISO Hiroyasu, TOYOSHIMA Hideaki, TAMAKOSHI Koji

    Diabetes Metab Res Rev   Vol. 28 ( 4 ) page: 349-356   2012.5

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    PMID:22228701

    DOI: DOI: 10.1002/dmrr.2277

  84. Multiple roles and all-cause mortality: the Japan Collaborative Cohort Study. Reviewed

    TAMAKOSHI Akiko, IKEDA Ai, FUJINO Yoshihisa, TAMAKOSHI Koji, ISO Hiroyasu

    Eur J Public Health     2012.1

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    Access below to see full text; http://eurpub.oxfordjournals.org/content/early/2012/01/11/eurpub.ckr194.long
    PMID:22241757

    DOI: doi: 10.1093/eurpub/ckr194

  85. Inverse relationship of serum adiponectin concentration with type 2 diabetes mellitus incidence in middle-aged Japanese workers: 6-year follow-up Reviewed

    LI Yuanying, HATSUYA Hiroshi, ISO Hiroyasu, TOYOSHIMA Hideaki, TAMAKOSHI Koji

    Diabetes Metab Res Rev     2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/dmrr.2277

  86. Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma Reviewed

    MAEDA Osamu, SHIBATA Kiyosumi, HOSONO Satoyo, FUJIWARA Sawako, KAJIYAMA Hiroaki, INO Kazuhiko, NAWA Akihiro, TAMAKOSHI Koji, KIKKAWA Fumitaka

    Int J Cancer     page: 113 - 121   2012.1

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    PMID:21328338

  87. Spectrin αII and βII tetramers contribute to platinum anticancer drug resistance in ovarian serous adenocarcinoma Reviewed

    MAEDA Osamu, SHIBATA Kiyosumi, HOSONO Satoyo, FUJIWARA Sawako, KAJIYAMA Hiroaki, INO Kazuhiko, NAWA Akihiro, TAMAKOSHI Koji, KIKKAWA Fumitaka

    Int J Cancer   Vol. 130 ( 1 ) page: 113-121   2012.1

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    PMID:21328338
    To overcome drug resistance in ovarian carcinoma, novel resistance mechanisms must be elucidated for clinical application. We purified 2 proteins in the 300 kDa range from cisplatin-resistant cells (NOS2CR2) by affinity chromatography with cisplatin-exposed Glutathione Sepharose 4B. The purified proteins were identified as spectrin αII and βII by peptide mass mapping analysis. Western blot analysis detected greater expression of spectrin αII and βII in NOS2CR2 than in wild-type cells (NOS2). The same result was obtained for spectrin βII expression by immunohistochemical staining. To determine whether spectrin αII and βII contribute to resistance, a drug sensitivity test was performed on SKOV3 ovarian cancer cells transfected with small interfering RNA. Sensitivity to platinum drugs was increased in the expression reduced cells. In a clinical study of five ovarian serous adenocarcinoma cases, tumor specimens taken after treatment with carboplatin stained more strongly for spectrin βII expression than untreated specimens. Fifty-two tumor specimens from 46 patients with ovarian serous adenocarcinoma were immunohistochemically stained for spectrin βII and scored. Tumors previously treated by chemotherapy scored higher than those not treated. Of 27 cases with detectable residual tumors at the time of surgery, cases scoring 4-6 had shorter progression-free survival periods after platinum-based chemotherapy than cases scoring 0-3 (p = 0.012). The cytoskeleton proteins Spectrin αII and βII contributed to drug resistance by anchoring the GS-Pt complex to the cell membrane, arresting cisplatin activity. Thus spectrin βII may be a useful predictor of platinum sensitivity in ovarian serous adenocarcinoma.

    DOI: 10.1002/ijc.25983

  88. Epidemiologic study of clinically amyopathic dermatomyositis and anti-melanoma differentiation-associated gene 5 antibodies in central Japan. Reviewed

    MURO Yoshinao, SUGIURA Kazumitsu, HOSHINO Kei, AKIYAMA Masashi, TAMAKOSHI Koji

    Arthritis Res Ther   Vol. 13 ( 6 ) page: 214   2011.12

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    INTRODUCTION: Several reports have found the onset or activity of inflammatory myopathies to show spatial clustering and seasonal association. We recently detected autoantibodies against melanoma differentiation-associated gene 5 (MDA-5) in more than 20% of patients with dermatomyositis. Anti-MDA-5 antibodies were associated with the presence of rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis (CADM). The present study aims to assess the growing prevalence of CADM and the geographical incidence of anti-MDA-5-positive patients.

    METHODS: We reviewed medical charts and examined the presence of anti-MDA-5 antibodies in 95 patients, including 36 CADM patients. Sera were obtained from 1994 through 2011. Statistical analyses were performed to assess whether CADM development and the presence of anti-MDA-5 antibodies were associated with various parameters, including age at disease onset, season of onset, annual positivity, and population of resident city.

    RESULTS: Tertiles based on the year when the sera were collected showed increasing tendencies of CADM and anti-MDA-5-positive patients among all of the dermatomyositis patients. From 1994 to 2010, the relative prevalence of CADM and anti-MDA-5 antibody-positive patients significantly increased. Interestingly, the presence of anti-MDA-5 antibodies in 26 patients was inversely associated with the population of their city of residence.

    CONCLUSIONS: This is the first study to examine the distribution of anti-MDA-5-positive dermatomyositis phenotypes in Japan. Regional differences in the incidences of these phenotypes would suggest that environmental factors contribute to the production of antibodies against MDA-5, which triggers innate antiviral responses.

  89. Number of children and all-cause mortality risk: results from the Japan Collaborative Cohort Study Reviewed

    TAMAKOSHI Akiko, TAMAKOSHI Koji, LIN Yingsong, MIKAMI Haruo, INABA Yutaka, YAGYU Kiyoko, KIKUCHI Syogo; for the JACC Study Group.

    Number of children and all-cause mortality risk: results from the Japan Collaborative Cohort Study     page: 732 - 737   2011.12

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    PMID: 21113028

  90. 女性における家族介護者の高血圧自覚の有無による血圧管理状況 Reviewed

    鈴木洋子, 堀容子, 星野純子, 濱本律子, 杉山晃子, 岡田武, 永井邦芳, 近藤高明, 玉腰浩司, 岡本和士, 長澤伸江, 豊嶋英明, 榊原久孝

    日本公衆衛生雑誌   Vol. 58 ( 12 ) page: 1016-1025   2011.12

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  91. Early age at menarche associated with increased all-cause mortality Reviewed

    TAMAKOSHI Koji, HATSUYA Hiroshi, TAMAKOSHI Akiko

    Eur J Epidemiol     2011.10

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    PMID:22006230

    DOI: 10.1007/s10654-011-9623-0

  92. Maternal mental disorders and pregnancy outcomes: A clinical study in a Japanese population Reviewed

    HIRONAKA Masae, KOTANI Tomomi, SUMIGAMA Seiji, TSUDA Hiroyuki, MANO Yukio, HAYAKAWA Hiromi, TANAKA Satoshi , OZAKI Norio, TAMAKOSHI Koji, KIKKAWA Fumitaka

    J Obstet Gynaecol Res   Vol. 37 ( 10 ) page: 1283-1289   2011.10

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    PMID:21535304

    DOI: 10.1111/j.1447-0756

  93. Comparison of salivary cortisol, heart rate, and oxygen saturation between early skin-to-skin contact with different initiation and duration times in healthy, full-term infants Reviewed

    TAKAHASHI Yuki, TAMAKOSHI Koji, MATSUSHIMA Miyoko, KAWABE Tsutomu

    Early Hum Dev   Vol. 87 ( 3 ) page: 151-157   2011.3

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    PMID:21220191
    BACKGROUND: There are few studies that compare the physiological and biological efficacies between different early skin-to-skin contacts (SSC) post birth.

    AIM: To investigate physiologically and biochemically how early SSC with different initiation and duration time influence the stress post birth for full-term infants.

    STUDY DESIGN: Non-experimental study.

    SUBJECTS: Study I; Thirty-two infants who began SSC 5min or less [birth SSC, mean initiation time (standard deviation): 1.6 (1.1) min] after birth and 36 infants who did so more than 5min [very early SSC, 26.3 (5.0) min] in heart rate (HR) and oxygen saturation (SpO(2)) analysis. Study II; Eighteen infants who underwent SSC for 60min or less [mean initiation time: 7.5 (12.2) min] and 61 infants who did so for more than 60min [15.3 (12.5) min] in salivary cortisol analysis.

    OUTCOME MEASURES: HR and SpO(2) measured for 30min post birth. Salivary cortisol concentration measured at 1min, 60min, and 120min post birth.

    RESULTS: Birth SSC group reached HR stability of 120-160bpm significantly faster than very early SSC group by Kaplan-Meier analysis (P=0.001 by log-rank test). As for SpO(2) stability of 92% and 96%, no significantly between-group difference was found. Salivary cortisol levels were significantly lower between 60 and 120min after birth in SSC group, continuing for more than 60min compared with SSC group for 60min or less after adjustment for salivary cortisol level at 1min besides the infant stress factors (P=0.046).

    CONCLUSIONS: Earlier SSC beginning within 5min post birth and longer SSC continuing for more than 60min within 120min post birth are beneficial for stability of cardiopulmonary dynamics and the reduction of infant stress during the early period post birth.

  94. 母娘二世代の母子健康手帳にみられる妊娠分娩経過の関連 Reviewed

    田辺圭子,玉腰浩司,室月淳

    母性衛生   Vol. 51 ( 4 ) page: 594-600   2011.1

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    近年、成人病胎児期起源仮説、Developmental Origin of Health and Disease(DOHaD)仮説が注目されている。今回、母娘二世代362組の母子健康手帳を用いて、二世代間の妊娠分娩経過の関連を検討した。世代間比較では、二世代目は一世代目に比べ身長が高く、妊娠中の平均収縮期血圧が低く、体重増加量が少なく、出生した児の体重が軽かった。また、分娩時出血量が多く、分娩様式では帝王切開を受けた人が多かった。一方、二世代間の非妊娠時体格、妊娠中期以降の血圧や体重増加量、出生児の出生体重と頭囲は統計学的に有意な正の関連を示した。また、重回帰分析による三世代目の出生体重に関連する因子の分析では、二世代目の出生体重が二世代目の非妊娠時のBMIや妊娠時の体重増加量より強く関連することが示された。本研究の結果により、世代間の妊娠分娩経過には、社会背景の変化や医療水準の向上などによる差異はあるものの、関連がみられた。また、前世代の胎内環境が次世代の胎内環境に影響を与えることが示唆された。以上より、前世代の妊娠分娩経過を知ることは、妊娠早期からの保健指導を可能にし、妊娠中の合併症の予防、さらにはその先に続いてゆく世代の健康につながっていく可能性が示唆された。

  95. Association of women's birth weight with their blood pressure during pregnancy and with the body size of their babies Reviewed

    TANABE Keiko, TAMAKOSHI Koji, MUROTSUKI Jun

    Tohoku J Exp Med   Vol. 224 ( 4 ) page: 287-292   2011

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    PMID:21791889
    The women's own intrauterine environment may influence their own pregnancy and their babies. The aim of our study was to investigate how a woman's birth weight affects the course of her pregnancy later in life as well as the body size of her babies; this study was based on the developmental origins of health and disease (DOHaD) concept. We collected Maternal and Child Health handbooks from 414 women and their biological mothers. They were classified into 3 categories based on the Fetal growth curve of Japan: light-for-date (LFD), which means birth weight is less than the -1.5SD; appropriate-for-date (AFD), which means it lies between the -1.5SD and +1.5SD; and heavy-for-date (HFD), which means it is in the +1.5SD, or higher. In the first trimester, systolic blood pressures (SBPs) were 117.6 (14.4 mmHg), 111.6 (12.4 mmHg), and 105.0 (11.6 mmHg), and diastolic blood pressures (DBP) were 71.0 (8.5 mmHg), 65.7 (9.4 mmHg), and 62.1 (8.7 mmHg) in women born LFD, AFD, and HFD, respectively (SBP: p for trend = 0.018, DBP: p for trend = 0.027). In the second and third trimesters, both SBP and DBP were higher for women born LFD than for those of the other 2 groups. Birth weights of the babies of women born LFD, AFD, and HFD were 2,791.1 (483.0 g), 3,043.4 (361.0 g), and 3,248.0 (431.5 g), respectively (p for trend < 0.01). Our findings support the DOHaD concept and suggest that intrauterine environment in fetal life may be passed down from generation to generation.

  96. Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies. Reviewed

    GKRANIA-KLOTSA Effrossyni, YE Zheng, COOPER Andrew J, SHARP Stephen J, LUBEN Robert, BIGGS Mary L, CHEN Liang-Kung, GOKULAKTISHNAN Kuppan, HANEFELD Markolf, INGELSSON Erik, LAI Wen-An, LIN Shih-Yi, LIND Lars, LOHSOONTHORN Vitool, MOHAN Viswanathan, MUSCARI Antonio, NILSSON Goran, OHRVIK John, CHAO QOANG Jiang, LENNY Nancy Swords, TAMAKOSHI Koji, TEMELKOVA-KURKTSCHIEV Theodora, WANG Ya-Yu, YAJNIK Chittaranjan Sakerlal, ZOLI Marco, KHAW Kay-Tee, FOROUHI Nita G, WAREHAM Nicholas J, LANGENBERG Claudia.

    PLoS One   Vol. 18 ( 5 ) page: 1-11   2010.10

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    PMID: 20976133

  97. Impact of smoking and other lifestyle factors on life expectancy among japanese: findings from the Japan Collaborative Cohort (JACC) Study. Reviewed

    TAMAKOSHI Akiko, KAWADO Miyuki, OZASA Kotaro, TAMAKOSHI Koji, LIN Yingsong, YAGYU Kiyoko, KIKUCHI Syogo, HASHIMOTO Suji; JACC Study Group.

    J Epidemiol   Vol. 20 ( 5 ) page: 370376   2010.9

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    PMID: 20631456
    BACKGROUND: A number of lifestyle factors, including smoking and drinking, are known to be independently associated with all-cause mortality. However, it might be more effective in motivating the public to adopt a healthier lifestyle if the combined effect of several lifestyle factors on all-cause mortality could be demonstrated in a straightforward manner.

    METHODS: We examined the combined effects of 6 healthy lifestyle behaviors on all-cause mortality by estimating life expectancies at 40 and 60 years of age among 62 106 participants in a prospective cohort study with a 14.5-year follow-up. The healthy behaviors selected were current nonsmoking, not heavily drinking, walking 1 hour or more per day, sleeping 6.5 to 7.4 hours per day, eating green leafy vegetables almost daily, and having a BMI between 18.5 to 24.9.

    RESULTS: At age 40, we found a 10.3-year increase in life expectancy for men and a 8.3-year increase for women who had all 6 healthy behaviors, as compared with those who had only 0 to 2 healthy behaviors. Increases of 9.6 and 8.2 years were observed for men and women, respectively, at age 60 with all 6 healthy behaviors. When comparing currently nonsmoking individuals with 0 to 1 healthy behaviors, the life expectancy of smokers was shorter in both men and women, even if they maintained all 5 other healthy behaviors.

    CONCLUSIONS: Among individuals aged 40 and 60 years, maintaining all 6 healthy lifestyle factors was associated with longer life expectancy. Smokers should be encouraged to quit smoking first and then to maintain or adopt the other 5 lifestyle factors.

  98. Body mass index and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanese cohorts using individual data. Reviewed

    YATSUYA Hiroshi, TOYOSHIMA Hideaki, YAMAHISHI Kazymasa, TAMAKOSHI Koji, TAGURI Masataka, HARADA Akiko, OHHASHI Yasuo, KITA Yoshikuni, NAITO Yoshihiko, YAMADA Michiko, TANABE Naohito, ISO Hiroyasu, UESHIMA Hirotsugu; Japan Arteriosclerosis Longitudinal Study (JALS) group.

    Circ Cardiovasc Qual Outcomes   Vol. 3 ( 5 ) page: 498-505   2010.9

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    PMID: 20699444

  99. Incidence of metabolic syndrome according to combinations of lifestyle factors among middle-aged Japanese male workers. Reviewed

    LI Yuanying, YATSUYA Hiroshi, ISO Hiroyasu, TAMAKOSHI Koji, TOYOSHIMA Hideaki.

    Prev Med   Vol. 51 ( 2 ) page: 118-122   2010.8

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    PMID: 20451548
    OBJECTIVE: To examine a combination of healthy lifestyles on the risk of metabolic syndrome (MetS) to inform future interventions.

    METHODS: A total of 1897 men aged 35-60 years participated in an annual health check-up in 2002 and 2005. MetS was defined by AHA/NCEP criteria. Logistic regression analyses were used to estimate age- and BMI-adjusted odds ratios (ORs) of MetS incidence for each healthy lifestyle (regular physical activity, adherence to healthy eating behaviors, not current smoking, and maintaining a stable weight since one's mid-twenties), separately (Model 1) and simultaneously (Model 2). A points system was developed to derive 3-year risk of MetS incidence by assigning a specific point to each healthy lifestyle.

    RESULTS: MetS developed in 285 (15.0%) subjects after the follow-up. The ORs of MetS for each healthy lifestyle ranged from 0.42 to 0.64 (Model 2). Three-year risk of MetS incidence was predicted to differ from 1% to 60% according to the individual point total of the points system. The population-attributable fraction of MetS in subjects whose point total was not in the highest quartile was 71%.

    CONCLUSION: Adherence to healthy lifestyles was associated with a lower risk of MetS among apparently healthy middle-aged Japanese male workers.

  100. Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. Reviewed

    MURAMATSU Takashi, YATSUYA Hiroshi, TOYOSHIMA Hideaki, SASAKI Satoshi, LI Yuanying, OTSUKA Rei, WADA Keiko, HOTTA Yo, MITSUHASHI Hirotsugu, MATSUSHITA Kunihiro, MUROHARA Toyoaki, TAMAKOSHI Koji.

    Prev Med   Vol. 50 ( 5-6 ) page: 272-276   2010.5

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    PMID: 20211645
    OBJECTIVE: To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA+DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake.

    METHOD: We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA+DHA intake as the reference were calculated by logistic regression analysis.

    RESULTS: Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA+DHA were 47.9 years, 22.9 kg/m(2), and 1.90 g/day (0.88%E) and 0.77 g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1=0.74, P for trend=0.01) and the association was observed only in subjects with a BMI of <25 kg/m(2) (P for interaction=0.033). However EPA+DHA showed no such associations consistently.

    CONCLUSION: Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women.

  101. Iron intake and associated factors in general Japanese population: NIPPON DATA80, NIPPON DATA90 and national nutrition monitoring. Reviewed

    YURIN Tanvir Chowdhury, OKUDA Nagako, MIURA Katsuyuki, NAKAMURA Yasuyuki, RUMADA Nahid, KADOTA Aya, TAMAKOSHI Koji, UESHIMA Hirotsugu; NIPPON DATA80/90 Research Group.

    J Epidemiol   Vol. Suppl 3   page: 557-566   2010.4

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    PMID: 20351478
    OBJECTIVE: The purpose of this study was to investigate the dietary iron intake and associated other dietary factors and clinical characteristics among a representative sample cohort of Japanese population.

    METHODS: We obtained data from NIPPON DATA80 and 90 that were conducted with the National Nutrition Surveys in 1980 and in 1990. Then we estimated nutrient and food intakes of individuals in the National Nutrition Survey of 1980 and that of 1990, which were adjusted on the basis of data of the National Nutrition Survey of 1995. Finally, we analyzed data for the 10,422 participants (4585 men and 5837 women) in NIPPON DATA80 and 8342 participants (3488 men and 4854 women) in NIPPON DATA90 having dietary iron intake information.

    RESULTS: In NIPPON DATA80 and 90, there was a significant relationship between the dietary iron intake and age for both men and women. Dietary protein intake was associated with iron intake where as dietary fat intake did not show any association. Regarding the minerals, significant relationships were observed between the different minerals and dietary iron intake. Apart from the food group of milk and dairy products, there were significant differences in other food groups according to quintiles of iron intakes for men and women.

    CONCLUSIONS: We described the mean dietary iron intake and its relation with other dietary factors and clinical characteristics in Japanese adults as the baseline data in NIPPON DATA80 and in NIPPON DATA90.

  102. BMI and all-cause mortality among Japanese older adults: findings from the Japan collaborative cohort study. Reviewed

    TAMAKOSHI Akiko, YATSUYA Hiroshi, LIN Yingsong, TAMAKOSHI Koji, KONDO Takaaki, SUZUKI Sadao, YAGYU Kiyoko, KIKUCHI Syogo; JACC Study Group.

    Obesity (Silver Spring)   Vol. 18 ( 2 ) page: 362-369   2010.2

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    PMID: 19543206
    The association between BMI and all-cause mortality may vary with gender, age, and ethnic groups. However, few prospective cohort studies have reported the relationship in older Asian populations. We evaluated the association between BMI and all-cause mortality in a cohort comprised 26,747 Japanese subjects aged 65-79 years at baseline (1988-1990). The study participants were followed for an average of 11.2 years. Proportional-hazards regression models were used to estimate mortality hazard ratios (HRs) and 95% confidence intervals. Until 2003, 9,256 deaths occurred. The underweight group was associated with a statistically higher risk of all-cause mortality compared with the mid-normal-range group (BMI: 20.0-22.9); resulting in a 1.78-fold (95% confidence interval: 1.45-2.20) and 2.55-fold (2.13-3.05) increase in mortality risk among severest thin men and women (BMI: <16.0), respectively. Even within the normal-range group, the lower normal-range group (BMI: 18.5-19.9) showed a statistically elevated risk. In contrast, being neither overweight (BMI: 25.0-29.9) nor obese (BMI: > or =30.0) elevated the risk among men; however among women, HR was slightly elevated in the obese group but not in the overweight group compared with the mid-normal-range group. Among Japanese older adults, a low BMI was associated with increased risk of all-cause mortality, even among those with a lower normal BMI range. The wide range of BMI between 20.0 and 29.9 in both older men and women showed the lowest all-cause mortality risk.

  103. Changes in activities of daily living, physical fitness, and depressive symptoms after six-month periodic well-rounded exercise programs for older adults living in nursing homes or special nursing facilities. Reviewed

    Ouyang P, Yatsuya H, Toyoshima H, Otsuka R, Wada K, Matsushita K, Ishikawa M, Yuanying L, Hotta Y, Mitsuhashi H, Muramatsu T, Kasuga N, Tamakoshi K.

    Nagoya J Med Sci   Vol. 71 ( 3-4 ) page: 115-126   2009.9

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  104. Healthy lifestyle and preventable death: findings from the Japan Collaborative Cohort (JACC) Study. Reviewed

    Tamakoshi A, Tamakoshi K, Lin Y, Yagyu K, Kikuchi S; JACC Study Group.

    Prev Med.   Vol. 48 ( 5 ) page: 486-492   2009.5

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  105. Self-reported medical history was generally accurate among Japanese workplace population. Reviewed

    Wada K, Yatsuya H, Ouyang P, Otsuka R, Mitsuhashi H, Takefuji S, Matsushita K, Sugiura K, Hotta Y, Toyoshima H, Tamakoshi K.

    J Clin Epidemiol.   Vol. 62 ( 3 ) page: 306-313   2009.3

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  106. Uric acid and left ventricular hypertrophy in Japanese men. Reviewed

    Mitsuhashi H, Yatsuya H, Matsushita K, Zhang H, Otsuka R, Muramatsu T, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H, Tamakoshi K.

    Circ J.   Vol. 73 ( 4 ) page: 667-672   2009.2

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  107. Multilevel analyses of effects of variation in body mass index on serum lipid concentrations in middle-aged Japanese men. Reviewed

    Kondo T, Kimata A, Yamamoto K, Ueyama S, Ueyama J, Yatsuya H, Tamakoshi K, Hori Y.

    Nagoya J Med Sci.   Vol. 71 ( 1-2 ) page: 19-28   2009.2

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  108. Effect of the interaction between mental stress and eating pattern on body mass index gain in healthy Japanese male workers. Reviewed

    Toyoshima H, Masuoka N, Hashimoto S, Otsuka R, Sasaki S, Tamakoshi K, Yatsuya H.

    J Epidemiol   Vol. 19 ( 2 ) page: 88-93   2009.2

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  109. Effect of physical activity on breast cancer risk: findings of the Japan collaborative cohort study. Reviewed

    Suzuki S, Kojima M, Tokudome S, Mori M, Sakauchi F, Fujino Y, Wakai K, Lin Y, Kikuchi S, Tamakoshi K, Yatsuya H, Tamakoshi A; Japan Collaborative Cohort Study Group.

    Cancer Epidemiol Biomarkers Prev.   Vol. 17 ( 12 ) page: 3396-3401   2008.12

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  110. Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: comparison of leptin and adiponectin. Reviewed

    Sugiura K, Tamakoshi K, Yatsuya H, Otsuka R, Wada K, Matsushita K, Kondo T, Hotta Y, Mitsuhashi H, Murohara T, Toyoshima H.

    Int J Cardiol.   Vol. 130 ( 2 ) page: 159-164   2008.11

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  111. Low leptin but high insulin resistance of smokers in Japanese men. Reviewed

    Hotta Y, Yatsuya H, Toyoshima H, Matsushita K, Mitsuhashi H, Takefuji S, Oiso Y, Tamakoshi K.

    Diabetes Res Clin Pract.   Vol. 81 ( 3 ) page: 358-364   2008.9

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  112. Development and validity of the Japanese version of body shape silhouette: relationship between self-rating silhouette and measured body mass index. Reviewed

    Nagasaka K, Tamakoshi K, Matsushita K, Toyoshima H, Yatsuya H.

    Nagoya J Med Sci   Vol. 70 ( 3-4 ) page: 89-96   2008.8

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  113. Having more healthy practice was associated with low white blood cell counts in middle-aged Japanese male and female workers. Reviewed

    Otsuka R, Tamakoshi K, Wada K, Matsushita K, Ouyang P, Hotta Y, Takefuji S, Mitsuhashi H, Toyoshima H, Shimokata H, Yatsuya H.

    Ind Health   Vol. 46 ( 4 ) page: 341-347   2008.8

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  114. 労働者の肥満と高血圧 Invited

    玉腰浩司,八谷寛

    血圧   Vol. 15 ( 6 ) page: 51-54   2008.6

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  115. *Association between low birth weight and elevated white blood cell count in adulthood within a Japanese population. Reviewed

    Wada K, Tamakoshi K, Ouyang P, Otsuka R, Mitsuhashi H, Takefuji S, Matsushita K, Sugiura K, Hotta Y, Toyoshima H, Yatsuya H.

    Circ J   Vol. 72 ( 5 ) page: 757-763   2008.5

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  116. Further inflammatory information on metabolic syndrome by adiponectin evaluation. Reviewed

    Matsushita K, Tamakoshi K, Yatsuya H, Wada K, Otsuka R, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H.

    Int J Cardiol   Vol. 124 ( 3 ) page: 339-344   2008.3

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  117. Eating fast leads to insulin resistance: findings in middle-aged Japanese men and women. Reviewed

    Otsuka R, Tamakoshi K, Yatsuya H, Wada K, Matsushita K, OuYang P, Hotta Y, Takefuji S, Mitsuhashi H, Sugiura K, Sasaki S, Kral JG, Toyoshima H.

    Prev Med.   Vol. 46 ( 2 ) page: 154-159   2008.2

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  118. Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Reviewed

    Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Mori M, Tamakoshi A; Japan Collaborative Cohort Study Group for Evaluation of Cancer Risk.

    J Epidemiol   Vol. 18 ( 2 ) page: 77-83   2008

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  119. Smoking status and adiponectin in healthy Japanese men and women. Reviewed

    Takefuji S, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Matsushita K, Sugiura K, Hotta Y, Mitsuhashi H, Oiso Y, Toyoshima H.

    Prev Med   Vol. 45 ( 6 ) page: 471-475   2007.12

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  120. Risk factors for first acute myocardial infarction attack assessed by cardiovascular disease registry data in Aichi Prefecture. Reviewed

    Kondo Y, Toyoshima H, Yatsuya H, Hirose K, Morikawa Y, Ikedo N, Masui T, Tamakoshi K.

    Nagoya J Med Sci   Vol. 69 ( 3-4 ) page: 139-147   2007.10

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  121. Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study). Reviewed

    Kondo T, Hori Y, Yatsuya H, Tamakoshi K, Toyoshima H, Nishino Y, Seki N, Ito Y, Suzuki K, Ozasa K, Watanabe Y, Ando M, Wakai K, Tamakoshi A.

    Cancer Causes Control   Vol. 18   page: 229-234   2007

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  122. *The transition to menopause reinforces adiponectin production and its contribution to insulin-resistant state. Reviewed

    Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, OuYang P, Sugiura K, Yo Hotta Y, Mitsuhashi H, Takefuji S, Kondo T, Toyoshima H.

    Clin Endocrinol   Vol. 66   page: 65-71   2007

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    OBJECTIVE: To evaluate the influence of menopausal status on the serum adiponectin concentration and investigate whether the contribution of adiponectin to insulin resistance is modified by menopausal status. SUBJECTS: We conducted a population-based, cross-sectional study of 207 premenopausal and 206 postmenopausal Japanese women. MEASUREMENTS: Data on anthropometric characteristics, fasting serum adiponectin, glucose and insulin concentrations were used. Insulin resistance (homeostasis model assessment of insulin resistance: HOMA-IR) was calculated. RESULTS: Postmenopausal women had significantly higher HOMA-IRs than premenopausal women [1.50 (1.42, 1.59) vs 1.18 (1.12, 1.24), geometric mean (1 standard error range), P = 0.005]. Paradoxically, adiponectin levels in postmenopausal women were also significantly higher than those in premenopausal women [10.3 (9.95, 10.7) vs 9.04 (8.71, 9.39), P = 0.028]. Multiple regression analysis showed that body mass index (BMI) was the only significantly independent predictor [standardized partial regression coefficients (sbeta) = 0.319, P < 0.001] for HOMA-IR among premenopausal women, whereas both BMI and adiponectin were the significant predictors among postmenopausal (sbeta = 0.334 and -0.141, P < 0.001 and < 0.05, respectively). When the subjects were restricted to those without metabolic disorders including high blood pressure, hypertriglyceridaemia, hypo-HDL cholesterolaemia and high fasting glucose, adiponectin (sbeta = -0.249, P < 0.05) was the only significant predictor for HOMA-IR among postmenopausal women but BMI was not significant (sbeta = 0.223, P = 0.075). CONCLUSIONS: The transition to menopause increases serum adiponectin concentrations. And the significant and negative association between adiponectin and HOMA-IR was observed only after menopause. Therefore, adiponectin may play a role in the improvement of an incipient insulin-resistant state after, rather than before, menopause.

  123. Results of the Health Assessment Questionnaire for Japanese patients with systemic sclerosis--measuring functional impairment in systemic sclerosis versus other connective tissue diseases. Reviewed

    Morita Y, Muro Y, Sugiura K, Tomita Y, Tamakoshi K.

    Clin Exp Rheumatol   Vol. 25   page: 367-372   2007

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  124. Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study. Reviewed

    Nishio K, Niwa Y, Toyoshima H, Tamakoshi K, Kondo T, Yatsuya H, Yamamoto A, Suzuki S, Tokudome S, Lin Y, Wakai K, Hamajima N, Tamakoshi A.

    Cancer Causes Control   Vol. 18   page: 801-808   2007

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  125. High-sensitivity C-reactive protein is quite low in Japanese men at high coronary risk. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Yang PO, Otsuka R, Wada K, Mitsuhashi H, Hotta Y, Kondo T, Murohara T, Toyoshima H.

    Circ J   Vol. 71   page: 820-825   2007

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  126. Adiponectin level and left ventricular hypertrophy in Japanese men. Reviewed

    Mitsuhashi H, Yatsuya H, Tamakoshi K, Matsushita K, Otsuka R, Wada K, Sugiura K, Takefuji S, Hotta Y, Kondo T, Murohara T, Toyoshima H.

    Hypertension   Vol. 49   page: 1448-1454   2007

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  127. Dietary fiber and risk of colorectal cancer in the Japan collaborative cohort study. Reviewed

    Wakai K, Date C, Fukui M, Tamakoshi K, Watanabe Y, Hayakawa N, Kojima M, Kawado M, Suzuki K, Hashimoto S, Tokudome S, Ozasa K, Suzuki S, Toyoshima H, Ito Y, Tamakoshi A; JACC Study Group.

    Cancer Epidemiol Biomarkers Prev   Vol. 16   page: 668-675   2007

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  128. White blood cell count and risk of all-cause and cardiovascular mortality in nationwide sample of Japanese--results from the NIPPON DATA90. Reviewed

    Tamakoshi K, Toyoshima H, Yatsuya H, Matsushita K, Okamura T, Hayakawa T, Okayama A, Ueshima H; NIPPON DATA90 Research Group.

    Circ J   Vol. 71   page: 479-485   2007

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  129. Psychological factors and insomnia among male civil servants in Japan. Reviewed

    Murata C, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Toyoshima H.

    Sleep Med   Vol. 8   page: 209-214   2007

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  130. Psychological attitudes and risk of breast cancer in Japan: a prospective study. Reviewed

    Wakai K, Kojima M, Nishio K, Suzuki S, Niwa Y, Lin Y, Kondo T, Yatsuya H, Tamakoshi K, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A; for the JACC Study Group.

    Cancer Causes Control   Vol. 18   page: 259-267   2007

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  131. A positive association between leptin and blood pressure of normal range in Japanese men. Reviewed

    Wada K, Yatsuya H, Tamakoshi K, Otsukai R, Fujii C, Matsushita K, Sugiura K, Toyoshima H.

    Hypertens Res   Vol. 29   page: 485-492   2006

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  132. *Eating fast leads to obesity: findings based on self-administered questionnaires among middle-aged Japanese men and women. Reviewed

    Otsuka R, Tamakoshi K, Yatsuya H, Murata C, Sekiya A, Wada K, Zhang HM, Matsushita K, Sugiura K, Takefuji S, OuYang P, Nagasawa N, Kondo T, Sasaki S, Toyoshima H.

    J Epidemiol   Vol. 16   page: 117-124   2006

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    BACKGROUND: Few epidemiologic studies have examined the association between the rate of eating and obesity. In this study, we cross-sectionally examined the association of the self-reported rate of eating with current Body Mass Index (BMI), and BMI-change from 20 years of age to the current age. METHODS: Subjects were 3737 male (mean age +/- standard deviation and mean BMI +/- standard deviation: 48.2 +/- 7.1 years and 23.3 +/- 2.7 kg/m(2)) and 1005 female (46.3 +/- 7.0 years and 21.8 +/- 2.8 kg/m(2)) Japanese civil servants. We measured self-reported categorical rate of eating, current BMI, BMI at age 20, and BMI-change from age 20. Energy intake was assessed over a 1-month period with a brief-type diet history questionnaire. RESULTS: The multiple regression analysis in which the current BMI was regressed by categorical rate of eating, energy intake, age, and lifestyle factors showed that current BMI steadily increased by -0.99, -0.67, 0.81, and 1.47 kg/m(2) along with the progress of categorical rate of eating from the 'medium' group to 'very slow', 'relatively slow', 'relatively fast', and 'very fast' groups, respectively, in men. In women, the corresponding values were -1.06, -0.35, 0.50, and 1.34 kg/m(2). When the BMI increment from age 20 to current age was regressed in the same manner, the increment was -0.63, -0.34, 0.57, and 1.05 kg/m(2) in men and -0.71, -0.32, 0.34, and 1.14 kg/m(2) in women, respectively. Additionally, both BMI at age 20 and current height were positively associated with rate of eating. CONCLUSIONS: Our results among middle-aged men and women suggest that eating fast would lead to obesity.

  133. *Birth weight and adult hypertension: cross-sectional study in a Japanese workplace population. Reviewed

    Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Yang PO, Sugiura K, Hotta Y, Mitsuhashi H, Kondo T, Toyoshima H.

    Circ J   Vol. 70   page: 262-267   2006

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    BACKGROUND: Low birth weight has been associated with adult hypertension in several Western populations. This association needs to be evaluated in Japanese people. METHODS AND RESULTS: A population-based cross-sectional study of 3,107 subjects (2,303 males and 804 females) aged 35-66 years was conducted. The participants responded to a questionnaire about their birth weights, blood pressure, medical history, parental history, and lifestyle factors. Hypertension was defined as systolic blood pressure > or =140 mmHg and/or diastolic blood pressure > or =90 mmHg and/or under treatment by anti-hypertensives. Multiple logistic regression analysis adjusted for age, sex, body mass index, parental history, and lifestyle revealed the adjusted odds ratios for hypertension were 1.26 (95% confidence interval: 0.88-1.80), 1.00 (reference), 0.89 (0.73-1.08) and 0.70 (0.49-1.00) in subjects in birth weight categories of <2,500 g, 2,500-<3,000 g, 3,000-<3,500 g, 3,500- g, respectively (p-value for trend =0.009). Furthermore, this inverse association was clearly pronounced in normal-weight subjects. CONCLUSION: Low birth weight was independently associated with adult hypertension in the Japanese workplace population. Our results support the inverse association observed previously in Western populations and suggest that intrauterine environmental insults might lead to permanent changes in the metabolism and structure of the fetal organs influencing the regulation of blood pressure.

  134. Low birth weight is associated with reduced adiponectin concentration in adult. Reviewed

    Tamakoshi K, Yatsuya H, Wada K, Matsushita K, Otsuka R, Sugiura K, Kondo T, Toyoshima H.

    Ann Epidemiol   Vol. 16   page: 669-674   2006

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    PURPOSE: Low birth weight has been associated with metabolic and vascular diseases, but the precise mechanism is debated. Adiponectin is one of the key molecules in metabolic disease, and a decrease in level precedes the onset of type 2 diabetes and development of atherosclerosis. Our aim is to examine whether low birth weight is associated with adiponectin concentration in adult. METHODS: We conducted a population-based cross-sectional study of 2277 subjects (1661 men and 616 women) aged 35 to 66 years who had their self-reported birth weights and adiponectin concentrations measured as adults. RESULTS: After adjusting for potential confounders, including age, sex, current body mass index (BMI), smoking status, alcohol consumption, and exercise, geometric mean adiponectin levels were 6.63, 6.45, 6.86, 7.05, 6.75, and 7.22 microg/mL for subjects with birth weights less than 2500, 2500 to less than 2800, 2800 to less than 3000, 3000 to less than 3200, 3200 to less than 3500, and greater than 3500 g, respectively. A positive association was found between birth weight and adiponectin concentration (trend p = 0.002). Stratified by current BMI of 25 kg/m2, a positive association was not observed for subjects with a BMI less than 25 kg/m2, but was pronounced in those with a BMI of 25 kg/m2 or greater. CONCLUSION: This study indicates that low birth weight contributes to decreased adiponectin concentrations in adult life independently of current BMI, especially for obese subjects.

  135. Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Zhang H, Sugiura K, Kondo T, Murohara T, Toyoshima H.

    Atherosclerosis   Vol. 188   page: 184-189   2006

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  136. Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. Reviewed

    Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Takefuji S, Sugiura K, Kondo T, Murohara T, Toyoshima H.

    Arterioscler Thromb Vasc Biol   Vol. 26   page: 871-876   2006

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  137. Association between parental histories of hypertension, diabetes and dyslipidemia and the clustering of these disorders in offspring. Reviewed

    Wada K, Tamakoshi K, Yatsuya H, Otsuka R, Murata C, Zhang H, Takefuji S, Matsushita K, Sugiura K, Toyoshima H.

    Prev Med   Vol. 42   page: 358-363   2006

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  138. Methods for myometrium closure and other factors impacting effects on cesarean section scars of the uterine segment detected by the ultrasonography . Reviewed

    Hayakawa H, Itakura A, Mitsui T, Okada M, Suzuki M, Tamakoshi K, Kikkawa F.

    Acta Obstet Gynecol Scand   Vol. 85   page: 429-434   2006

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  139. Determinants of self-rated health: Could health status explain the association between self-rated health and mortality? . Reviewed

    Murata C, Kondo T, Tamakoshi K, Yatsuya H , Toyoshima H.

    Arch Gerontol Geriatr   Vol. 43   page: 369-380   2006

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  140. Plasma fibrinogen levels and cardiovascular risk factors in Japanese schoolchildren. Reviewed

    Fujii C, Sakakibara H, Kondo T, Yatsuya H, Tamakoshi K, Toyoshima H.

    J Epidemiol   Vol. 16   page: 64-70   2006

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  141. Factors related to frequency of engaging in outside activities among elderly persons living an independent life at home. Reviewed

    Ishikawa M, Tamakoshi K, Yatsuya H, Suma K, Wada K, Otsuka R, Matsushita K, Zhang H, Murata C, Kondo T, Toyoshima H.

    Nagoya J Med Sci   Vol. 68   page: 121-130   2006

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  142. Factors associated with life space among community-living rural elders in Japan. Reviewed

    Murata C, Kondo T, Tamakoshi K, Yatsuya H, Toyoshima H.

    Public Health Nursing   Vol. 23   page: 324-331   2006

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  143. Perceived psychological stress and serum leptin concentration in Japanese men. Reviewed

    Otsuka R, Yatsuya H, Tamakoshi K, Matsushita K, Wada K, Toyoshima H.

    Obesity   Vol. 14   page: 1-7   2006

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  144. Relationship between body mass index and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort (JACC) study. Reviewed

    Niwa Y, Yatsuya H, Tamakoshi K, Nishio K, Kondo T, Lin Y, Suzuki S, Wakai K, Tokudome S, Yamamoto A, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

    J Obstet Gynaecol Res.   Vol. 31 ( 5 ) page: 452-458   2005.10

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    AIM: The incidence of ovarian cancer in Japan has increased since the 1970s. The many studies that have assessed the relationship between body mass index (BMI) and the risk of ovarian cancer have produced contradictory results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, which was initiated in 1988. METHODS: A self-administered questionnaire on dietary habits and other risk factors for cancer was completed by 36,456 Japanese women. After 7.6 years of follow up, 38 cases of ovarian cancer were available for analysis. Cox proportional-hazards models were used to compute relative risks and to adjust for confounders. RESULTS: Compared to women with BMI of 18.5-24.9 kg/m2, the relative risk of ovarian cancer was 2.24 (95% CI = 1.10-4.21) for BMI of 25.0-29.9 and 1.78 (95% CI = 0.24-13.34) for BMI of > or = 30 kg/m2. A test for trend revealed that this finding was statistically significant (P = 0.014). CONCLUSION: The results of this study suggest that being overweight is independently associated with a higher risk of developing ovarian cancer in the Japanese population.

  145. Prospective study of alcohol consumption and breast cancer risk in Japanese women. Reviewed

    Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A.

    Int J Cancer.   Vol. 116 ( 5 ) page: 779-783   2005.9

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    Epidemiologic evidence is lacking for the association between alcohol consumption and the risk of breast cancer in Japanese women. We addressed this association in a prospective cohort study with an average follow-up of 7.6 years. At baseline (1988-1990), cohort participants completed a self-administered questionnaire that included alcohol use, reproductive history and hormone use. The women were followed up for breast cancer incidence through December 31, 1997. Cox proportional hazards models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for breast cancer incidence and any association with alcohol consumption. During a follow-up of 271,412 person-years, we identified 151 women with breast cancer, of whom 45 were current drinkers and 11 drank > or =15 g of alcohol/day. After adjustment for age and other potential risk factors for breast cancer, the RR for current drinkers was 1.27 (95% CI 0.87-1.84) compared to nondrinkers. Average alcohol intake of <15 g/day did not significantly increase the risk for breast cancer. However, risk was significantly increased for women who consumed > or =15 g/day of alcohol (RR = 2.93, 95% CI 1.55-5.54). Age at starting drinking and frequency of consumption per week were not significantly associated with breast cancer risk. Our cohort study demonstrated that Japanese women who consume at least a moderate amount of alcohol have an increased risk of breast cancer.

  146. Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. Reviewed

    Wakai K, Tamakoshi K, Date C, Fukui M, Suzuki S, Lin Y, Niwa Y, Nishio K, Yatsuya H, Kondo T, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A; JACC Study Group.

    Cancer Sci.   Vol. 96 ( 9 ) page: 590-599   2005.9

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  147. Validity of self-reported height and weight in a Japanese workplace population. Reviewed

    Wada K, Tamakoshi K, Tsunekawa T, Otsuka R, Zhang H, Murata C, Nagasawa N, Matsushita K, Sugiura K, Yatsuya H, Toyoshima H.

    Int J Obes Relat Metab Disord.   Vol. 29 ( 9 ) page: 1093-1099   2005.9

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    OBJECTIVE: To assess the validity of self-reported height and weight in a Japanese workplace population, and to examine factors associated with the validity of self-reported weight. DESIGN: Comparison of self-reported height and weight with independent measurement. SUBJECTS: In total, 4253 men and 1148 women aged 35-64 y (mean measured body mass index (BMI): 23.3 kg/m(2) in men, 21.9 kg/m(2) in women) were included in the study. MEASUREMENTS: Self-reported height and weight were obtained by a self-administered questionnaire. Measured height and weight were based on annual health checkups. Sex, age, measured BMI, and the presence of hypertension, diabetes, and hyperlipidemia were examined as potential factors associated with the accuracy of self-reported weight. RESULTS: Self-reported height and weight were highly correlated with measured height and weight for men and women (Pearson's r for men and women: 0.979 and 0.988 in height, 0.961 and 0.959 in weight, 0.943 and 0.950 in BMI, respectively). For men, mean differences+/-2 s.d. of height and weight were 0.078+/-2.324 cm and -0.034+/-5.012 kg, respectively, and for women 0.029+/-1.652 cm and 0.024+/-4.192 kg, respectively. The prevalence of obesity with BMI > or =25 kg/m(2) based on self-reported data (23.6 and 11.5% for men and women, respectively) was slightly smaller than that based on measured data (24.9 and 12.4%, respectively). Specificity and sensitivity, however, were quite high for both men and women (sensitivity was 85.8 and 85.2%, and specificity was 97.0 and 98.9%, respectively). The subjects with higher measured BMI significantly underestimated their weight compared with those with smaller BMI after adjustments for age in men and women. Furthermore, the presence of diabetes in men and age in women affected self-reported weight. Neither the presence of hypertension nor hyperlipidemia was associated with reporting bias. CONCLUSION: The self-reported height and weight were generally reliable in the middle

  148. Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women. Reviewed

    Mabuchi T, Yatsuya H, Tamakoshi K, Otsuka R, Nagasawa N, Zhang H, Murata C, Wada K, Ishikawa M, Hori Y, Kondo T, Hashimoto S, Toyoshima H.

    Diabetes Metab Res Rev.   Vol. 21 ( 5 ) page: 441-447   2005.7

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    BACKGROUND: Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. METHODS: Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were analyzed in relation to their WBC count. Serum leptin concentrations and WBC counts were measured by radioimmunoassay and automated particle counter respectively, using samples obtained at the time of the participants' annual health checkups. RESULTS: The geometric mean (+/-geometric standard deviation) leptin concentrations were 3.25 +/- 1.82 ng/mL and 6.25 +/- 3.99 ng/mL, and the geometric mean WBC counts, 5770 +/- 1269/mm(3) and 5107 +/- 1228/mm(3), in men and women respectively. The WBC count adjusted for age, body mass index (BMI), physical activity, and drinking and smoking habits increased together with the increase in leptin concentration. Multiple linear regression against WBC count by the leptin concentration and those covariates revealed a significant and independent association with serum leptin concentration especially in women (standardized beta = 0.31, p < 0.001), and also in men (standardized beta = 0.17, p < 0.001). BMI was not significantly associated with WBC counts in the multivariate model adjusting for leptin levels in both sexes. CONCLUSIONS: Our results are in line with leptin's hematopoietic or proinflammatory functions. The increased WBC counts often observed in obese people would be mediated by the increased leptin concentration.

  149. Serum levels of insulin-like growth factor I, II, and binding protein 3, transforming growth factor beta-1, soluble fas ligand and superoxide dismutase activity in stomach cancer cases and their controls in the JACC Study. Reviewed

    Yatsuya H, Toyoshima H, Tamakoshi K, Tamakoshi A, Kondo T, Hayakawa N, Sakata K, Kikuchi S, Hoshiyama Y, Fujino Y, Mizoue T, Tokui N, Yoshimura T; JACC Study Group.

    J Epidemiol.   Vol. S2   page: S120-125.   2005.7

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    BACKGROUND: The prognosis of stomach cancer with advanced stage remains poor. New biomarkers of the disease that may contribute to establish the potential screening strategy would be of value for the early detection of individuals at high risk of the disease. METHODS: We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the Japan Collaborative Cohort (JACC) Study, to evaluate serum levels of insulin-like growth factor I, II, and binding protein 3 (IFG-I, IGF-II, and IGFBP-3), transforming growth factorbeta-1 (TGFbeta1), soluble fas (sFas) and superoxide dismutase activity (SOD) in 210 stomach cancer cases diagnosed in the JACC Study in relation to those levels in their 410 controls. RESULTS: Among 6 serum biomarkers tested for case-control differences, only sFas level in female stomach cancer cases was significantly higher than that of controls (2.22 pg/ml vs. 2.04 pg/mL, respectively; P=0.013 by two-way analysis of covariance controlling for matching variable). CONCLUSION: None of the biomarkers consistently predicted future risk of stomach cancer in both men and women in the present analysis. Serum sFas level in women, however, should be studied much more thoroughly whether it provides meaningful refinement of risk stratification, or it elucidate the mechanisms of tumorigenesis in women.

  150. Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan. Reviewed

    Tamakoshi K, Toyoshima H, Wakai K, Kojima M, Suzuki K, Watanabe Y, Hayakawa N, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A.

    Oncology.   Vol. 68 ( 4-6 ) page: 454-461   2005.7

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    OBJECTIVE: To elucidate whether leptin is involved in the etiology of female colorectal cancer. METHODS: A case-control study nested in the Japan Collaborative Cohort Study. We compared serum leptin levels in 58 cases of female colorectal cancer with those in 145 controls matched for study area and age. Data were analyzed using a conditional logistic regression model with adjustments for known risk factors for the development of colorectal cancer. Quintile cutoff points were determined on the distribution of leptin levels in cases and controls combined. RESULTS: Serum geometric mean levels of leptin were 6.88 ng/ml in cases and 6.00 ng/ml in controls. The odds ratios of female colorectal cancer risk were 1.40 (95% confidence interval, CI: 0.41-4.78) for the category of the second and third quintiles combined, and 4.84 (CI: 1.29-18.1) for the category of the fourth and fifth quintiles combined relative to the first quintile after adjustment for body mass index (BMI), life-style factors, reproductive factors, and hormonal variables including insulin-like growth factor and its binding protein. CONCLUSION: Our results suggest that leptin most likely increases the risk of female colorectal cancer substantially independent of BMI.

  151. Medical history of circulatory diseases and colorectal cancer death in the JACC Study. Reviewed

    Watanabe Y, Ozasa K, Ito Y, Suzuki K, Kojima M, Suzuki S, Tokudome S, Tamakoshi K, Toyoshima H, Kawado M, Hashimoto S, Hayakawa N, Wakai K, Tamakoshi A; JACC Study Group.

    J Epidemiol.   Vol. S2   page: S168-172   2005.6

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    BACKGROUND: Host factors expressed by individual past medical history of hypertension, stroke, and myocardial infarction may have a relationship with colorectal cancer. METHODS: As part of the Japan Collaborative Cohort Study (JACC Study) for the Evaluation of Cancer Risk sponsored by the Ministry of Education, Science, Sports and Culture of Japan (Monbusho), we conducted a follow-up study of 110,792 Japanese inhabitants aged 40-79 years to reveal the relationship of past medical history of hypertension, stroke, and myocardial infarction at the baseline in 1988-1990 with colorectal cancer death for about 10 years up to the end of 1999. RESULTS: Past medical history of hypertension associated with an increased risk of female rectal cancer when analyzing all cancer cases with adjustment for age, body mass index, and exercise (hazard ratio [HR]=1.97, 95% confidence interval [CI]; 1.13-3.43). Past medical history of myocardial infarction was also an increased risk for female rectal cancer (HR=3.05, 95% CI; 1.28-7.28). Females who had a medical history of stroke had increased risk of rectal cancer without statistical significance. CONCLUSION: There was a positive association of past medical history of hypertension and myocardial infarction and an increased risk of rectal cancer in women.

  152. Colorectal cancer and serum C-reactive protein levels: a case-control study nested in the JACC Study. Reviewed

    Ito Y, Suzuki K, Tamakoshi K, Wakai K, Kojima M, Ozasa K, Watanabe Y, Kawado M, Hashimoto S, Suzuki S, Tokudome S, Toyoshima H, Hayakawa N, Kato K, Watanabe M, Ohta Y, Maruta M, Tamakoshi A; JACC Study Group.

    J Epidemiol.   Vol. S2   page: S185-189   2005.6

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    BACKGROUND: Recently, it has been hypothesized that inflammation increases the risk of colorectal cancer. We investigated whether serum levels of C-reactive protein (CRP), a biomarker of inflammation, are associated with colorectal cancer, using serum samples collected in the Japan Collaborative Cohort Study (JACC Study). METHODS: We conducted a nested case-control study in the JACC Study, investigating the relationship between the risk for colorectal cancer and serum levels of CRP determined by a high-sensitivity CRP enzyme immunoassay. The subjects recruited were 141 patients with colorectal cancer (63 males and 78 females) and 327 controls with no history of cancer (148 males and 179 females). Each case of colorectal cancer was matched for sex, age and participating institution to 2 or 3 controls. We used ttest to analyze mean differences in CRP levels between colorectal cancer cases and controls. Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using a conditional logistic regression model after adjusting for the potential confounding factors. RESULTS: Serum CRP levels were not clearly associated with the risk of colorectal cancer. The OR of the highest serum CRP levels was 1.18 (95% CI: 0.68-2.06) for colorectal cancer and 1.42 (95% CI: 0.73-2.74) for colon cancer, compared to subjects with lowest serum levels. The OR for incidence of colorectal cancer showed a similar trend, but the difference was not significant. Thus, high serum CRP levels did not appear to increase the risk of colorectal cancer. CONCLUSIONS: The present results suggest that high serum CRP levels are not associated with the risk of colorectal cancer in the JACC Study.

  153. Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese People. Reviewed

    Ozasa K, Ito Y, Suzuki K, Watanabe Y, Kojima M, Suzuki S, Tokudome S, Tamakoshi K, Toyoshima H, Kawado M, Hashimoto S, Hayakawa N, Wakai K, Tamakoshi A; JACC Study Group.

    J Epidemiol.   Vol. S2   page: S180-184   2005.6

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    BACKGROUND: Glucose intolerance may increase the risk of developing colorectal cancer. METHODS: In a sero-epidemiological nested case-control study, conducted as part of the Japan Collaborative Cohort Study (JACC Study) for Evaluation of Cancer Risk, we measured serum glycoalbumin in 123 patients with colorectal cancer and 279 controls. Conditional logistic regression was used to evaluate the risk of colorectal cancer. RESULTS: There were trends towards an association between high levels of glycoalbumin and an increased risk of colorectal cancer in men (odds ratio [OR]=2.39; 95% confidence interval [CI]; 0.89- 6.36) and between high levels of glycoalbumin and a decreased risk of colorectal cancer in women (OR=0.41; 95% CI, 0.14-1.04). CONCLUSIONS: A high level of glycoalbumin may increase the risk of colorectal cancer in men. The finding that high levels of glycoalbumin in women decreased their risk of colorectal cancer was inconsistent with previous reports, and may have been the result of limitations in the procedure in selecting samples and statistical power.

  154. Alcohol consumption and colorectal cancer risk: findings from the JACC Study. Reviewed

    Wakai K, Kojima M, Tamakoshi K, Watanabe Y, Hayakawa N, Suzuki K, Hashimoto S, Kawado M, Tokudome S, Suzuki S, Ozasa K, Toyoshima H, Ito Y, Tamakoshi A; JACC Study Group.

    J Epidemiol.   Vol. S2   page: S173-179   2005.6

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    BACKGROUND: Because alcohol drinking is a potential risk factor for colorectal cancer, the trend in alcohol consumption in Japan may partly explain the increase in incidence and mortality rates of this malignancy until 1990-1995. METHODS: We analyzed data from the Japan Collaborative Cohort Study. From 1988 to 1990, 23,708 men and 34,028 women, aged 40-79 years, completed a questionnaire on lifestyle factors including drinking habits. Incidence rate ratios (IRR) were estimated by using proportional hazards models. RESULTS: During the mean follow-up of 7.6 years through December 1997, we documented 418 incidents of colon cancer and 211 of rectal cancer. Male ex- or current drinkers demonstrated a twofold risk for colon cancer compared with nondrinkers: the multivariate-adjusted IRR was 2.01 (95% confidence interval [CI] 1.09-3.68) for ex-drinkers and 1.97 (95% CI: 1.28-3.03) for current drinkers. The doseresponse relationship between alcohol consumption and the risk, however, was not clear. Female exdrinkers were at an increased risk without statistical significance. For rectal cancer, we found a slightly lower risk in light current drinkers who consumed less than 22 g ethanol per day: the multivariate IRR was 0.61 (95% CI: 0.33-1.13) for men and 0.69 (95% CI: 0.27-1.74) for women. Although the IRR for all current drinkers was almost unity in men, an increasing trend in risk was detected with increasing alcohol consumption in current drinkers (trend p=0.027). CONCLUSIONS: Taking the findings from our study and other prospective investigations into consideration, more attention should be paid to alcohol consumption in the prevention of colon cancer in Japan.

  155. Effects of social relationships on mortality among the elderly in a Japanese rural area: an 88-month follow-up study. Reviewed

    Murata C, Kondo T, Hori Y, Miyao D, Tamakoshi K, Yatsuya H, Sakakibara H, Toyoshima H.

    J Epidemiol.   Vol. 15 ( 3 ) page: 78-84   2005.5

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    BACKGROUND: The association between social relationships and lower mortality has been well documented in Western countries. This study aims to investigate that association among elderly Japanese in a rural area. METHODS: An analysis was conducted with 1,994 subjects (58.1% women), 78.3% of the total elderly aged 65 and older in a town, who were independent in activities of daily living. A baseline survey was carried out in 1992, and subjects were followed until 1999. Cox proportional hazard models examined the association between social relationships (availability of casual friend/ support provider, group membership, job, living arrangement) and an 88-month mortality. RESULTS: A significant association between social relationships and mortality was observed among the old-old (aged 75 and older). Among men, having a job and group membership were significantly associated with lower mortality with hazard ratios (95% confidence intervals) of 0.62 (0.41-0.94) and 0.60 (0.40-0.90), respectively, after adjustment for age, diagnosed illnesses, self-rated health, other social relationships, annual income, and home ownership. Among women, having a job and living alone were significantly associated with lower mortality with hazard ratios (95% confidence intervals) of 0.67 (0.45-0.99) and 0.35 (0.13-0.97), respectively. CONCLUSIONS: Social relationships such as having a job and group membership were associated with lower mortality among the old-old. In addition, old-old women living alone were better off in terms of mortality after adjustment for possible confounders. This suggests the importance of considering family relationships in terms of quality in areas where multi-generation households prevail.

  156. Cigarette smoking and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort study. Reviewed

    Niwa Y, Wakai K, Suzuki S, Tamakoshi K, Lin Y, Yatsuya H, Kondo T, Nishio K, Yamamoto A, Tokudome S, Hamajima N, Toyoshima H, Tamakoshi A; JACC Study Group.

    J Obstet Gynaecol Res.   Vol. 31 ( 2 ) page: 144-151   2005.4

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    AIM: The many studies into the relation between cigarette smoking and the risk of ovarian cancer have produced inconsistent results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, initiated in 1988. METHODS: A self-administered questionnaire on smoking habits and other risk factors for cancer was completed by 34 639 Japanese women. After 7.6 years of follow up, 39 cases of ovarian cancer were available for analyses. Cox proportional-hazards models were used to compute relative risks (RR) and to adjust for confounders. RESULTS: Relative to those who had never smoked, the RR of ovarian cancer were 1.63 (95% confidence interval [CI] = 0.21-12.50) for former smokers and 2.27 (95% CI = 0.85-6.08) for current smokers. Among current smokers, the RR were 1.48 (95% CI = 0.20-10.92), 5.56 (95% CI = 1.68-19.06), and 1.86 (95% CI = 0.25-14.30) among women who smoked <10, 10-19, and at least 20 pack-years ([number of cigarettes smoked per day/20] x number of years subject has smoked), respectively, relative to those who had never smoked. A test for trend was statistically significant (P = 0.044). CONCLUSIONS: These data indicate that cigarette smoking increases the risk of developing ovarian cancer in the Japanese population.

  157. Lack of an association between serum level of transforming growth factor beta -1 and stomach cancer risk in the JACC study. Reviewed

    Yatsuya H, Tamakoshi A, Tamakoshi K, Hoshiyama Y, Fujino Y, Tokui N, Mizoue T, Kikuchi S, Sakata K, Hayakawa N, Kondo T, Toyoshima H, Yoshimura T.

    Asian Pac J Cancer Prev.   Vol. 6 ( 2 ) page: 170-176   2005.4

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    Alterations in the serum concentration of transforming growth factor beta-1 (TGFbeta1) have been observed in gastric cancer patients. No study, however, has ever examined the association between the serum TGFbeta1 level and stomach cancer prospectively. We conducted a prospective, nested case-control analysis among apparently healthy men and women who were followed for up to 8 years in the JACC Study to assess whether serum level of total TGFbeta1 is associated with a subsequent risk of stomach cancer. The concentration of serum TGFbeta1 in previously collected blood samples was analyzed by ELISA for 209 individuals in whom a diagnosis of stomach cancer was documented, and for 409 controls matched with them for gender, age and study area. Baseline blood levels of TGFbeta1 were not related to the risk of stomach cancer in either men or women, a finding unchanged even after adjustment for potential confounders. The multivariate-adjusted odds ratio of stomach cancer in men and women was 1.10 (95% CI, 0.82 to 1.48) and 1.09 (95% CI, 0.80 to 1.48), respectively, for each increase of 1 SD in the TGFbeta1 value. In conclusion, serum TGFbeta1 levels were not associated with increased risks of subsequent stomach cancer.gene A52C polymorphism related to the metabolism of long-chain fatty acids and oxidized LDL in the etiology of colorectal cancer.

  158. Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: a prospective study. Reviewed

    Kojima M, Wakai K, Tokudome S, Suzuki K, Tamakoshi K, Watanabe Y, Kawado M, Hashimoto S, Hayakawa N, Ozasa K, Toyoshima H, Suzuki S, Ito Y, Tamakoshi A; JACC Study Group.

    Am J Epidemiol.   Vol. 161 ( 5 ) page: 462-471   2005.3

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    To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80 degrees C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total omega-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), alpha-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of omega-6 polyunsaturated fatty acids on colorectal cancer risk were detected.

  159. Familial aggregation and coaggregation of history of hypertension and stroke. Reviewed

    Kondo T, Toyoshima H, Tsuzuki Y, Hori Y, Yatsuya H, Tamakoshi K, Tamakoshi A, Ohno Y; JACC Study Group.

    J Hum Hypertens.   Vol. 19 ( 2 ) page: 119-125   2005.2

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    We attempted to evaluate familial aggregation and coaggregation of history of hypertension and stroke. Past and family history of hypertension and stroke for 83 089 probands and their relatives were obtained from a data set for the Japan Collaborative Cohort Study for Evaluation of Cancer Risk sponsored by the Ministry of Education (JACC Study), which was initiated from 1988 to 1990. First, evaluation was performed for familial aggregation of each of two disorders using ordinal logistic regression of the generalized estimation equations (GEE) to account for dependence of observations within families. Secondly, in order to evaluate the familial congregation of the history of hypertension and stroke, a GEE-based multivariate probed predictive model was applied. After adjusting for the proband's age, level of obesity, smoking status, drinking status, habitation area, and the gender and type of the relatives, the estimated odds ratios for the intraindividual clustering and familial aggregation of the disease history showed statistically significant relationships. In addition, the history of the two disorders showed a significant relationship in terms of familial coaggregation independently of the aggregation of each disorder itself. Our results confirmed that hypertension and stroke coaggregate strongly within families through possible effects of genetic factors, which, alone or in conjunction with environmental factors, influence susceptibility to both hypertension and stroke.

  160. Long-term body weight fluctuation is associated with metabolic syndrome independent of current body mass index among Japanese men. Reviewed

    Zhang H, Tamakoshi K, Yatsuya H, Murata C, Wada K, Otsuka R, Nagasawa N, Ishikawa M, Sugiura K, Matsushita K, Hori Y, Kondo T, Toyoshima H.

    Circ J.   Vol. 69 ( 1 ) page: 13-18   2005.1

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    BACKGROUND: The relation between weight fluctuation and the risk of cardiovascular disease (CVD) is fairly consistent, although the physiologic basis for the relationship is uncertain. In the present study the association between long-term weight fluctuation and the development of metabolic syndrome (MS), a potent CVD risk factor, was investigated. METHODS AND RESULTS: A cross-sectional study of 664 Japanese men aged 40-49 years was conducted. The root mean square error around the slope of weight on age (weight - RMSE) was calculated by a simple linear regression model, in which the subject's actual weights at ages 20, 25, 30 years and 5 years prior to the study, as well as current weight, were dependent variables against the subject's age as the independent variable. Weight-RMSE was significantly and positively associated with the prevalence of each MS components (high blood pressure, hypertriglyceridemia, low-high density lipoprotein-cholesterol, high fasting glucose, and obesity). Such associations, as well as clustering of the MS component together with RMSE increase, were apparent among subjects with body mass index (BMI) <25 kg/m2, although the prevalence of MS or its components was much higher among overweight subjects (BMI >or=25 kg/m2). CONCLUSIONS: Development of MS possibly explains the risk of CVD not only in overweight or obese persons, but also in normal-weight persons with large weight fluctuation.

  161. Perceived psychologic stress and colorectal cancer mortality: findings from the Japan Collaborative Cohort Study. Reviewed

    Kojima M, Wakai K, Tokudome S, Tamakoshi K, Toyoshima H, Watanabe Y, Hayakawa N, Suzuki K, Hashimoto S, Kawado M, Suzuki S, Ito Y, Tamakoshi A; JACC Study Group.

    Psychosom Med.   Vol. 67 ( 1 ) page: 72-77   2005.1

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    OBJECTIVE: The purpose of this research was to examine the relationship between perceived psychologic stress and colorectal cancer mortality in a prospective large-scale study. METHODS: Between the years 1988 and 1990, 32,153 men and 45,854 women aged 40 to 79 years were enrolled. Participants completed a self-administered questionnaire that addressed demographic, lifestyle, and psychosocial characteristics. Subjects were subsequently followed for mortality until the end of 1999. Perceived psychologic stress was assessed using the question "Do you feel stress during your daily life?" The 4 possible responses, ranging from "little or none" (1) to "extreme" (4), were dichotomized as low (1 or 2) or high (3 or 4) stress. Relative risks (RRs) with 95% confidence intervals (CIs) for colon and rectal cancer according to the perceived level of stress were estimated using Cox's proportional hazard model. RESULTS: During the follow-up period (average, 9.6 years), 193 colon cancer deaths (96 men and 97 women) and 127 rectal cancer deaths (88 men and 39 women) were confirmed within the study group. Women who reported high stress had a 1.64-fold higher risk of colon cancer mortality (multivariate-adjusted RR, 1.64; 95% CI, 1.01-2.66) compared with those reporting low stress. There was no significant association between perceived stress and female rectal cancer or male colon and rectal cancer mortality. CONCLUSIONS: Perceived psychologic stress was weakly associated with increased mortality from colon cancer in women. No positive or inverse association was found in men. Further studies are needed to confirm our results.

  162. Impact of menstrual and reproductive factors on breast cancer risk in Japan: results of the JACC study. Reviewed

    Tamakoshi K, Yatsuya H, Wakai K, Suzuki S, Nishio K, Lin Y, Niwa Y, Kondo T, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A; JACC Study Group.

    Cancer Sci.   Vol. 96 ( 1 ) page: 57-62   2005.1

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    The incidence of breast cancer among Japanese women, a traditionally low-risk population, has increased substantially. To evaluate the association of reproductive factors with breast cancer risk, we examined 38,159 Japanese women, aged 40-79 years, who responded to a questionnaire on reproductive and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study. During an average 7.6 years of follow-up, we documented 151 incidents of breast cancers. Cox proportional hazards modeling was employed to estimate relative risks (RR) and 95% confidence intervals (CI). There was a significant decline in the risk of breast cancer with increasing parity among parous women (trend P=0.01). Women with four or more parities had a 69% lower risk than uniparous women, a reduced risk was also evident among menopausal women. Breast cancer risk tended to rise with increasing age at first delivery (trend P=0.05), the association being very apparent among menopausal women (trend P=0.02). Compared to the women who had their first delivery before age 25, those who delayed this event until after age 34 had an RR of 2.12 (95% CI: 0.72-6.21) and 3.33 (1.07-10.3) among the overall subjects and the menopausal, respectively. There was no apparent association of breast cancer risk with age at menarche or menopause. Our study concerning reproductive risk factors suggests that breast cancer in Japan is similar to that in Western countries, and that reproductive factors, particularly the number of parity and age at first delivery, might be important in the etiology of breast cancer among Japanese women.

  163. Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort: effect modification by sex for carotenoids. Reviewed

    Wakai K, Suzuki K, Ito Y, Kojima M, Tamakoshi K, Watanabe Y, Toyoshima H, Hayakawa N, Hashimoto S, Tokudome S, Suzuki S, Kawado M, Ozasa K, Tamakoshi A; Japan Collaborative Cohort Study Group.

    Nutr Cancer.   Vol. 51 ( 1 ) page: 13-24   2005

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    To examine associations of serum carotenoids, retinol, and tocopherols with colorectal cancer risk, we conducted a case-control study nested within the Japan Collaborative Cohort Study. These micronutrients were measured in prediagnostic serum samples from 116 men and women who developed colorectal cancer during an 8-yr follow-up period and from 298 matched controls. In men, the higher level of serum total carotenoids was associated with a decreased risk: The multivariate-adjusted odds ratio (OR) for the highest vs. the lowest tertile was 0.34 (95% confidence interval [CI] = 0.11-1.00; trend P over tertiles = 0.040). In women, the higher levels of alpha- and and total carotenoids were instead related to an increased risk: The corresponding ORs were 4.72 (95% CI = 1.29-17.3), 2.00 (0.70-5.73), and 2.47 (0.73-8.34), respectively (trend P = 0.007, 0.040, and 0.064, respectively). We also found a somewhat decreasing risk with increased serum retinol in all subjects and alpha-tocopherol in men: The ORs (95% CI) for the highest tertiles were 0.29 (0.11-0.78; trend P over tertiles = 0.010) and 0.29 (0.07-1.17; trend P = 0.098), respectively. The effects of some carotenoids on colorectal cancer risk may be modified by sex or by factors associated with sex, including smoking and drinking habits.

  164. 職域コホート男性における血清レプチン濃度と生活習慣との関連

    大塚礼, 豊嶋英明, 八谷寛, 張恵明, 和田恵子, 村田千代栄, 堀容子, 近藤高明, 玉腰浩司

    日本循環器病予防学会誌   Vol. 40   page: 123-130   2005

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  165. 出生時体重と成人期の生活習慣病との関連 Reviewed

    玉腰浩司、八谷寛、大塚礼、和田恵子、張恵明、豊嶋英明

    現代医学   Vol. 52   page: 321-325   2005

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  166. Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: a case-control study nested in the Japan Collaborative Cohort Study. Reviewed

    Suzuki K, Ito Y, Wakai K, Kawado M, Hashimoto S, Toyoshima H, Kojima M, Tokudome S, Hayakawa N, Watanabe Y, Tamakoshi K, Suzuki S, Ozasa K, Tamakoshi A; Japan Collaborative Cohort Study Group.

    Cancer Epidemiol Biomarkers Prev.   Vol. 13 ( 11 ) page: 1781-1787   2004.11

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    Oxidative stress plays an important role in carcinogenesis, but few epidemiologic studies have examined associations with risk of colorectal cancer. Relationships between serum levels of oxidized low-density lipoprotein (oxLDL) and oxLDL antibody (oLAB) and colorectal cancer risk were investigated in a case-control study nested in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. Serum samples and lifestyle information were collected at baseline from 39,242 men and women between 1988 and 1990. Of these, 161 incidents and deaths from colorectal cancer were identified through 1999, and 395 controls were matched for gender, age, and study area. Measurements were taken of serum oxLDL levels in 119 cases and 316 controls and serum oLAB levels in 153 cases and 376 controls. Odds ratios (95% confidence intervals) across quartiles, adjusted for confounding factors, were 1.55 (0.70-3.46), 1.90 (0.84-4.28), and 3.65 (1.50-8.92) for oxLDL (P(trend) = 0.004) and 0.98 (0.54-1.80), 0.75 (0.39-1.48), and 1.68 (0.90-3.13) for oLAB (P(trend) = 0.140). Further adjustment for serum total cholesterol and alpha-tocopherol did not materially change these associations. Odds ratio (95% confidence interval) of the highest quartile of serum oxLDL compared with the lowest quartile was 3.40 (1.09-10.58; P(trend) = 0.045). Analyses restricted to colon cancer cases and corresponding controls yielded similar relationships between serum oxLDL and oLAB levels and risk. In conclusion, higher levels of serum oxLDL may increase risk of colorectal cancer.

  167. Association of white blood cell count and clustered components of metabolic syndrome in Japanese men. Reviewed

    Nagasawa N, Tamakoshi K, Yatsuya H, Hori Y, Ishikawa M, Murata C, Zhang H, Wada K, Otsuka R, Mabuchi T, Kondo T, Toyoshima H.

    Circ J.   Vol. 68 ( 10 ) page: 892-897   2004.10

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    BACKGROUND: The role of inflammation in the genesis of cardiovascular disease has attracted attention and in the present study the association among metabolic syndrome (MS), white blood cell (WBC) count, and insulin concentration was investigated. METHODS AND RESULTS: A cross-sectional study of 3,594 Japanese men aged 34-69 years evaluated the MS components (high blood pressure, hypo-high density lipoprotein (HDL)-cholesterolemia, hypertriglyceridemia, hyperglycemia), as defined by the criteria given in the Third Report of the National Cholesterol Education Program Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults, except for obesity [body mass index (BMI) >/=25 kg/m(2)]. WBC count had a positive correlation with BMI, blood pressure, triglyceride, glucose and insulin, and a negative correlation with HDL-cholesterol. The multi-adjusted means of WBC count and insulin concentration were significantly higher in MS subjects defined as having 3 or more of the components than in non-MS subjects with no more than 2 components. Both means also increased with the number of MS components (p<0.001 for trend). In the multiple linear regression analysis, BMI, HDL-cholesterol, systolic blood pressure, glucose and triglyceride had a significant and independent association with WBC count, but the insulin concentration did not. CONCLUSIONS: The cluster of MS components based on insulin resistance may cause low-grade inflammation.

  168. Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case-control study. Reviewed

    Yatsuya H, Toyoshima H, Tamakoshi A, Kikuchi S, Tamakoshi K, Kondo T, Mizoue T, Tokui N, Hoshiyama Y, Sakata K, Hayakawa N, Yoshimura T; Japan Collaborative Cohort Study Group.

    Br J Cancer.   Vol. 91 ( 5 ) page: 929-934   2004.8

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    We used 202 cases of stomach cancer and 394 controls nested within the Japan Collaborative Cohort Study For Evaluation of Cancer Risk (JACC study) to investigate whether family history has an independent effect on the risk of stomach cancer after controlling for the Helicobacter pylori infection. A positive history of stomach cancer in one or more first-degree relatives was associated with an increased risk of the disease in women, but not in men after controlling for H. pylori infection and other confounding variables. Women with both a family history and H. pylori infection were associated with more than five-fold increased risk of the disease (OR 5.10, 95% CI 1.58-16.5) compared to those without these factors. These results suggest the existence of inherited susceptibility to the disease in women, and that measurements of H. pylori infection together with the family history allow meaningful evaluation of risk beyond that provided by either factor alone.

  169. A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: findings from the JACC study. Reviewed

    Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A; JACC Study Group.

    Cancer Sci.   Vol. 95 ( 7 ) page: 602-607   2004.7

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    The effects of reproductive factors on the etiology of colon cancer in Asian populations remain unexplored. So we examined 38,420 Japanese women aged 40-79 years who responded to a questionnaire on reproductive and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. During an average 7.6 years of follow-up, we documented 207 incident colon cancers. Multivariate analysis indicated that colon cancer risk was likely to be lower among parous women than among nulliparous. Women who had two abortions or more had a 72% higher risk of developing colon cancer [relative risk (RR) 1.72; 95% confidence interval (CI) 1.16-2.55; trend P < 0.01] compared with women who never had an abortion. The RR of colon cancer among postmenopausal women significantly decreased with increasing age at menarche (trend P = 0.01). No apparent association between colon cancer and gravida, age at first birth, age at menopause, or duration of menstruation was seen. These prospective data support the hypothesis that female reproductive events modify colon cancer risk, and suggest that reproductive factors, particularly age at menarche and having an abortion, may be of importance in the etiology of colon cancer among Japanese women.

  170. Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha. Reviewed

    Sumigama S, Ito T, Kajiyama H, Shibata K, Tamakoshi K, Kikkawa F, Williams T, Tainsky MA, Nomura S, Mizutani S.

    Oncogene.   Vol. 15 ( 32 ) page: 5496-5504   2004.7

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    A previous report demonstrated that AP-2alpha favors the survival of ovarian cancer patients by clinical findings. However, the functional roles of AP-2alpha in human ovarian cancers have not been determined. To clarify the roles, we overexpressed AP-2alpha in SKOV3 human ovarian cancer cells, which originally possess little AP-2alpha. AP-2alpha overexpression changed cell morphology from spindle to epithelioid type and suppressed cell proliferation and invasion, which would be partially correlated with decreased phosphorylation levels of the erbB2, Akt and ERK pathways, increased E-cadherin and reduced pro-matrix metalloproteinase-2 levels. Moreover, nude mice intraperitoneally injected with AP-2alpha-overexpressing cells survived longer than those with neo-transfected cells. The present data represent the first direct evidence that AP-2alpha plays a tumor suppressive role in ovarian cancer.

  171. A prospective study of body size and colon cancer mortality in Japan: The JACC Study. Reviewed

    Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

    Int J Obes Relat Metab Disord.   Vol. 28 ( 4 ) page: 551-558   2004.4

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    OBJECTIVE: To determine whether body size measurements are risk factors for colon cancer death among the Japanese. DESIGN AND SUBJECTS: A nationwide prospective study, the Japan Collaborative Cohort (JACC) Study from 1988 to 1999. The present analysis included 43 171 men and 58 775 women aged 40-79 y who respond to a questionnaire on current weight and height, weight around 20 y of age, and other lifestyle factors. Body mass index (BMI) at baseline and 20 y of age (B-BMI and 20-BMI, respectively) were calculated. RESULTS: We identified 127 deaths from colon cancer during the follow-up of 424 698 person-years among men and 122 deaths during the follow-up of 591 787 person-years among women. After adjustments for the lifestyle factors known to modify the risk of colon cancer, weight at baseline showed a significant positive association in women, while no such association was seen in men. There was also a significant trend of increasing risk with the increase in B-BMI among women. Women with B-BMI >/=28 kg/m(2) had a relative risk (RR) of 3.41 (95% confidence interval (CI): 1.44-8.06) compared with those with BMI of 20-<22 kg/m(2). 20-BMI also presented the same trend of increasing risk as B-BMI. Women with 20-BMI of <22 and B-BMI of >26 kg/m(2), that is, excessive BMI gain, had a high RR of 3.41 (95% CI 1.29-9.02) compared with those with 20-BMI of <22 and B-BMI of <22 kg/m(2). There were no corresponding trends of colon cancer risk for B-BMI, 20-BMI, or BMI change among men. CONCLUSIONS: These study data suggest that obesity and excessive weight gain are associated with the risk of colon cancer death in Japanese women but no such relationship was found in Japanese men.

  172. Bowel movement frequency and risk of colorectal cancer in a large cohort study of Japanese men and women. Reviewed

    Kojima M, Wakai K, Tokudome S, Tamakoshi K, Toyoshima H, Watanabe Y, Hayakawa N, Suzuki K, Hashimoto S, Ito Y, Tamakoshi A; JACC Study Group.

    Br J Cancer   Vol. 90 ( 7 ) page: 1397-1401   2004.4

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    The relationship between bowel movement (BM) frequency and the risk of colorectal cancer was examined in a large cohort of 25 731 men and 37 198 women living in 24 communities in Japan. At enrolment, each participant completed a self-administrated questionnaire on BM frequency and laxative use. Incidence rate ratios (IRR) with 95% confidence intervals (CI) were estimated using Cox's proportional-hazard model. During the follow-up period (average length 7.6 years), 649 cases of colorectal cancer, including 429 cases of colon cancer, were identified. Among women, subjects who reported a BM every 2-3 days had the lowest risk of developing colorectal (IRR=0.71, 95% CI=0.52-0.97) and colon cancer (IRR=0.70, 95% CI=0.49-1.00), whereas those reporting a BM every 6 days or less had an increased risk of developing colorectal (IRR=2.47, 95% CI=1.01-6.01) and colon cancer (IRR=2.52, 95% CI=0.93-6.82) compared with those reporting >or=1 BM per day. A similar, but nonsignificant, association between the frequency of BM and cancer risk was observed in men. There was no association between colorectal or colon cancer risk and laxative use. Regulating BM frequency might therefore have a role in the prevention of colorectal cancer.

  173. A prospective study on the possible association between having children and colon cancer risk: findings from the JACC Study. Reviewed

    Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki K, Ito Y, Tamakoshi A; JACC Study Group.

    Cancer Sci.   Vol. 95 ( 3 ) page: 243-247   2004.3

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    If having children is regarded as an exposure in life, its effect on a host could be considered as being due to female sex hormones associated with pregnancy in women and some lifestyle factors associated with large families in both men and women. To explore the roles of having children in the etiology of colon cancer, we examined 36,629 women and 24,877 men aged 40-79 years who completed a questionnaire on the number of children and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. During 291,080 and 200,648 person-years of follow-up, we documented 198 female and 202 male incident colon cancers, respectively. After adjusting for some factors known or suspected to modify the risk of colon cancer, compared with the women with no children, the multivariate-adjusted relative risks of colon cancer were 0.74 (95% confidence interval [CI]: 0.30-1.84) for one child, 1.00 (95% CI: 0.46-2.20) for two, 0.70 (95% CI: 0.31-1.55) for three, and 0.59 (95% CI: 0.26-1.33) for four or more. The risk of colon cancer showed a significantly monotonic decrease with increasing number of children (P value for trend = 0.047). There was no association between the number of children and colon cancer risk among men. From these prospective data, having children may reduce risk of colon cancer among women, but not among men, suggesting that modifications of hormone profiles secondary to pregnancies may influence female colon cancer risk.

  174. Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases. Reviewed

    Yatsuya H, Tamakoshi K, Hattori H, Otsuka R, Wada K, Zhang H, Mabuchi T, Ishikawa M, Murata C, Yoshida T, Kondo T, Toyoshima H

    Circ J   Vol. 68 ( 1 ) page: 11-16   2004.1

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    BACKGROUND: Phospholipid transfer protein (PLTP) can generate pre-beta high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. The transfer of phospholipids to immature HDL is also essential in maintaining reverse cholesterol transport. The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; however, little information is available concerning the relationship between PLTP mass and disease. METHODS AND RESULTS: Using a sandwich enzyme-linked immunosorbent assay, PLTP concentration was measured and related to the risk of developing cardiovascular disease in a worksite-based cohort of Japanese men (n=2,567). Multiple linear regression analysis showed significant associations between PLTP and HDL cholesterol, triglycerides, low-density lipoprotein cholesterol, and body mass index (standardized beta=0.395, -0.191, -0.064, and -0.064, respectively; R(2)=0.31). During the follow-up period, there were 10 cases of coronary heart disease (CHD) and 7 of stroke. The multivariate adjusted relative risk of CHD was 0.46 (95% confidence interval, 0.20-1.07) for an increase of 1 standard deviation in the PLTP value (p=0.071). PLTP concentration was not related to the risk of stroke. CONCLUSIONS: The results of this prospective study indicate that the serum PLTP concentration would serve as a predictor of CHD, independent of HDL cholesterol, triglycerides and other established risk factors.

  175. Diet and colorectal cancer mortality: results from the Japan Collaborative Cohort Study. Reviewed

    Kojima M, Wakai K, Tamakoshi K, Tokudome S, Toyoshima H, Watanabe Y, Hayakawa N, Suzuki K, Hashimoto S, Ito Y, Tamakoshi A; Japan Collaborative Cohort Study Group.

    Nutr Cancer.   Vol. 50 ( 1 ) page: 23-32   2004

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    The relationship between diet and colorectal cancer mortality was analyzed in a prospective study of 45,181 men and 62,643 women aged 40-79 yr enrolled in the Japan Collaborative Cohort Study. Between 1988 and 1990, subjects completed a self-administered questionnaire on their sociodemographic characteristics, diet, and other lifestyle habits. During the follow-up period (average 9.9 yr), 284 colon cancer deaths (138 men and 146 women) and 173 rectal cancer deaths (116 men and 57 women) were confirmed. The only significant association of colorectal cancer mortality with vegetable intake was observed between male rectal cancer mortality and green leafy vegetable consumption [hazard ratio (HR) using Cox proportional hazard models = 0.6; 95% confidence interval (CI) = 0.3-0.9; P for trend = 0.02]. Yogurt intake was also inversely associated with male rectal cancer mortality (HR = 0.5; 95% CI = 0.2-1.0; P for trend = 0.04). Egg consumption was positively associated with male colon cancer mortality (P for trend = 0.04). Women with high fruit consumption had increased colon cancer mortality (HR = 1.6; 95% CI = 1.0-2.6; P for trend = 0.04). It should be noted that this study lacked statistical power due to small sample size and measurement error in the food-frequency questionnaire. Further investigation is therefore necessary to confirm the association between diet and colorectal cancer, especially by subsites and gender.

  176. 肥満者における心血管疾患発症の過剰リスクを説明する新しい軸 血清レプチン値と白血球数の関連

    八谷寛, 間淵智子, 大塚礼, 和田恵子, 長澤伸江, 張恵明, 村田千代栄, 石川美由紀, 堀容子, 近藤高明, 玉腰浩司, 豊嶋英明

      Vol. 20   page: 19-25   2004

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  177. 人間ドックの有効性と限界

    玉腰浩司、八谷寛、豊嶋英明

    総合臨床   Vol. 53   page: 2435-2338   2004

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  178. 日本人男性における血清レプチン濃度と5年間追跡後の体重変化

    八谷寛, 玉腰浩司, 大塚礼, 間淵智子, 和田恵子, 張恵明, 村田千代栄, 石川美由紀, 近藤高明, 豊嶋英明

    健康医科学研究助成論文集   Vol. 19   page: 110-117   2004

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  179. 肥満を伴った高脂血症患者に対する運動療法の効果に関する研究 行動医学的アプローチを用いた運動習慣の定着による動脈硬化促進要因の改善に関する研究

    下光輝一, 井上茂, 小田切優子, 高波嘉一, 豊嶋英明, 八谷寛, 玉腰浩司, 近藤高明, 井口ちよ

    医科学応用研究財団研究報告   Vol. 21   page: 215-223   2004

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  180. Long-term body weight variability is associated with elevated C-reactive protein independent of current body mass index among Japanese men. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Ishikawa M, Zhang H, Murata C, Otsuka R, Mabuchi T, Hori Y, Zhu S, Yoshida T, Toyoshima H.

    Int J Obes Relat Metab Disord.   Vol. 27 ( 9 ) page: 1059-1065   2003.9

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    OBJECTIVE: To elucidate the effect of long-term weight variability on C-reactive protein (CRP) levels. DESIGN: Cross-sectional study of the circulating CRP. SUBJECTS: A total of 637 Japanese men aged 40-49 y in1997. MEASUREMENTS: Serum CRP levels, body mass index in 1997 (current BMI), the slope of weight on age (weight-slope) representing an individual's weight trend of direction and magnitude, and the root mean square error around the slope of weight on age (weight-RMSE) representing the weight fluctuation magnitude, as calculated by a simple linear regression model in which each value of the subject's five actual weights (aged 20, 25, 30 y, five years ago, and current) was a dependent variable and the subject's ages independent variables. RESULTS: After adjustment for age and confounders, including smoking and health status, the odds ratios of elevated CRP (> or =0.06 mg/dl) were 1.83 (95% CI: 1.25-2.69), 2.63 (1.69-4.11), and 10.31 (2.17-48.98) for upper normal-weight (BMI: 22-<25 kg/m(2)), overweight (25-<30), and obese (> or =30) persons, respectively, compared with lower normal-weight persons (18.5-<22). Adjusting for age, confounders, and current BMI, weight-slope was positively associated with CRP level especially among subjects with BMI> or =25 kg/m(2) (trend P<0.01), and weight-RMSE was positively associated with CRP level particularly among subjects with BMI <25 kg/m(2) (trend P<0.05). CONCLUSION: Our results suggest a state of low-grade systemic inflammation not only in overweight and obese persons, but also in normal-weight persons with large weight fluctuation, possibly explaining in part the positive association between weight fluctuation and CVD.

  181. Association between weight fluctuation and fasting insulin concentration in Japanese men. Reviewed

    Yatsuya H, Tamakoshi K, Yoshida T, Hori Y, Zhang H, Ishikawa M, Zhu S, Kondo T, Toyoshima H.

    Int J Obes Relat Metab Disord.   Vol. 27 ( 4 ) page: 478-483   2003.4

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    OBJECTIVE: To investigate whether long-term weight fluctuation is associated with the fasting serum insulin concentration. DESIGN AND SUBJECTS: Weight histories of 1932 male Japanese workers aged 40-59 y were analyzed in relation to their current fasting serum insulin concentration. MEASUREMENTS: Individual weight fluctuation was calculated by root mean square error (RMSE) along the linear regression line of weight measured at five to six different ages. RESULTS: The mean RMSE and fasting insulin concentration were 1.22 kg and 4.5 microU/ml, respectively. The multivariate adjusted insulin level became higher with the increase in weight fluctuation. Subanalysis stratified by current body mass index (BMI) showed that the multivariate adjusted insulin level in individuals in the top quartile of fluctuation was 4.3 microU/ml, against 3.9 microU/ml in those in the bottom quartile (P=0.018, analysis of covariance (ANCOVA)) in the normal weight subgroup with current BMI below 25 kg/m(2). In the overweight subgroup with BMI 25 kg/m(2) or above, the level was 6.9 microU/ml in individuals in the top quartile and 6.2 microU/ml in those in the bottom quartile (P=0.054, ANCOVA). CONCLUSION: The results suggest that weight fluctuation increases the risk of developing hyperinsulinemia. Prospective observations together with measurement of changes in adiposity are needed for confirmation.

  182. *The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Ishikawa M, Zhang H, Murata C, Otsuka R, Zhu S, Toyoshima H.

    Int J Obes Relat Metab Disord.   Vol. 27 ( 4 ) page: 443-449   2003.4

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    OBJECTIVE: To elucidate the underlying mechanisms between C-reactive protein (CRP) and cardiovascular disease, we examined the association of circulating CRP in healthy reference range (< or =1.0 mg/dl) measured by high-sensitive CRP assay with the metabolic syndrome (MS). DESIGN: Cross-sectional study of circulating CRP in adult men. SUBJECTS: A total of 3692 Japanese men aged 34-69 y. MEASUREMENTS: Serum CRP, total cholesterol, triglycerides, LDL-cholesterol, fasting glucose, fasting insulin, uric acid, systolic blood pressure, diastolic blood pressure, and body mass index (BMI). RESULTS: There was a statistically significant positive correlation between CRP and BMI (r=0.25), total cholesterol (r=0.096), triglycerides (r=0.22), LDL-cholesterol (r=0.12), fasting glucose (r=0.088), fasting insulin (r=0.17), uric acid (r=0.13), systolic blood pressure (r=0.12), and diastolic blood pressure (r=0.11), and a significant negative correlation of CRP with HDL-cholesterol (r=0.24). After adjusting for age, smoking, and all other components of MS, obesity, hypertriglyceridemia, hyper-LDL-cholesterolemia, diabetes, hyperinsulinemia, and hyperuricemia were significantly associated with both mildly (> or =0.06 mg/dl) and moderately (> or =0.11 mg/dl) elevated CRP. Compared with men who had no such components of the MS, those who had one, two, three, four, and five or more components were, respectively, 1.48, 1.84, 1.92, 3.42, and 4.17 times more likely to have mildly elevated CRP levels (trend P<0.001). As for moderately elevated CRP, the same association was observed. CONCLUSIONS: These results indicate that a variety of components of the MS are associated with elevated CRP levels in a systemic low-grade inflammatory state.

  183. U-shaped association between white blood cell count and fasting plasma glucose level. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Hori Y, Zhang H, Ishikawa M, Murata C, Otsuka R, Zhu S, Toyoshima H.

    Diabetes Care.   Vol. 26 ( 3 ) page: 950   2003.3

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  184. The accuracy of long-term recall of past body weight in Japanese adult men. Reviewed

    Tamakoshi K, Yatsuya H, Kondo T, Hirano T, Hori Y, Yoshida T, Toyoshima H.

    Int J Obes Relat Metab Disord.   Vol. 27 ( 2 ) page: 247-252   2003.2

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    OBJECTIVE: To examine the influences of recall period, current body weight, weight gain and loss, and weight variability on the accuracy of long-term recall of past weight. DESIGN AND SUBJECTS: Comparison of recalled weights around 25 y old with weights measured at age 25y in health checkup records among 2453 Japanese men (age: 34-61 y). MEASUREMENTS: Deviations between reported and measured weights were examined as to the three indexes: actual error (reported-measured), percent error (actual error/measured x 100), and absolute value of the percent error. Weight variability was defined as (1) the coefficient of variation of weight (CV) and (2) the root mean square error around the slope of weight on age (RMSE). RESULTS: Recalled weight strongly correlated with measured weight (r=0.849). Correlation coefficients decreased as age or the elapsed time since age 25y increased. Recalled weight (mean=58.3 kg) was slightly greater than measured weight at age 25y (mean=57.0 kg, mean actual error=1.28 kg). Subjects with a current body mass index (BMI) of less than 28.6 kg/m(2) overestimated their past weights, whereas those with BM1 of 28.6 kg/m(2) or over underestimated it. Subjects with weight loss since age 25y underestimated their past weights, whereas those with stable weight or gain overestimated it. There were monotonic increases in the three indexes of deviation across the CV quartile categories. Concerning the effect RMSE, a similar trend was observed. CONCLUSION: These results indicate that past body weights over a long period seem to be recalled with good accuracy. However, it should be kept in mind when using recalled weight in an epidemiologic study that accuracy of recall is influenced by age or elapsed time, current BMI, weight gain and loss, and weight variability.

  185. Trends in the mortality (1950-1997) and incidence (1975-1993) of malignant ovarian neoplasm among Japanese women: analyses by age, time, and birth cohort. Reviewed

    Tamakoshi K, Kondo T, Yatsuya H, Hori Y, Kikkawa F, Toyoshima H.

    Gynecol Oncol.   Vol. 83 ( 1 ) page: 64-71   2001.10

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    OBJECTIVE: The purpose of this study was to explore epidemiological features of malignant ovarian neoplasm in Japan. METHODS: The number of deaths from malignant ovarian neoplasm was obtained from the national vital statistics. Estimated incidence rates, based on several cancer registries, were also used for analyses. We divided the subjects into two age groups (0-29 and 30+ years) and examined secular trends in mortality (1950-1997) and incidence (1975-1993) by age, time, and birth cohort. RESULTS: The age-adjusted mortality rate has increased approximately 4-fold (from 0.9 to 3.6 per 100,000 women) from 1950 to 1997. Age-specific mortality rates showed a rising pattern in the elderly, whereas mortality in the younger people tended to increase in the 1950s and 1960s, but then decreased in the 1970s and afterward. In analyses using a mathematical model, the time effect in the population aged 0-29 years increased with advancing period up to 1970, and then decreased. The cohort effects had positive values, which indicate higher than additive influence from age/time effect, for birth cohorts from 1900 to 1935. The age-adjusted incidence rate increased approximately 1.5-fold (from 3.6 to 5.7) from 1975 to 1993. The rate increased in the early 1980s, but has remained stable since the late 1980s. Age-specific incidence rates in older age groups increased steadily up to 1985, and have remained stable since, while the rates in younger women have remained almost unchanged. CONCLUSION: The major effects on malignant ovarian neoplasm in Japan are supposed to be due to declining parity and therapeutic improvements.

  186. Clinical behavior of borderline ovarian tumors: a study of 150 cases. Reviewed

    Tamakoshi K, Kikkawa F, Nakashima N, Tamakoshi A, Kawai M, Furuhashi Y, Hattori SE, Kuzuya K, Arii Y, Suganuma N, Tomoda Y.

    J Surg Oncol.   Vol. 64 ( 2 ) page: 147-152   1997.2

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    BACKGROUND: We evaluated the clinical features, treatment, and survival status of the patients with borderline ovarian tumors. METHODS: A retrospective review of the charts of 150 patients with borderline ovarian tumor registered at the Tokai Ovarian Tumor Study Group from January 1, 1980, to December 31, 1994, was conducted to obtain clinical and pathological information. RESULTS: In stage II and III disease, the numbers of patients with no residual tumor, residual tumor of <2 cm, 2-5 cm, and >5 cm were 9, 10, 3, and 3, respectively. The sizes of residual tumors and corresponding clinical response to chemotherapy were as follows: residual tumor of <2 cm, complete response (CR), 6 patients; no change (NC), 2; progressive disease (PD), 2; tumors 2-5 cm, NC, 1 patient, PD, 2; tumors >5 cm, PD, 3 patients. The survival for patients with residual tumor <2 cm was significantly better than for those with residual tumor from 2-5 cm and of >5 cm (P < 0.05). The survival for patients with stage II and III serous tumor was significantly longer than that for patients with stage II and III mucinous tumor (P < 0.05). CONCLUSION: In advanced borderline ovarian tumor, the prognosis of patients with gross residual tumor after initial surgery, and especially with mucinous tumor, was poor.

  187. Hyaluronidase activity in gynaecological cancer tissues with different metastatic forms. Reviewed

    Tamakoshi K, Kikkawa F, Maeda O, Suganuma N, Yamagata S, Yamagata T, Tomoda Y.

    Br J Cancer.   Vol. 75 ( 12 ) page: 1807-1811   1997

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    We investigated hyaluronidase activity in gynaecological normal and malignant tissues. Hyaluronidase activity in culture medium of tissue specimens was detected by hyaluronic acid zymography and quantified by densitometry. Hyaluronidase activity was shown as one dominant band (molecular weight 65 kDa) at pH 3.5. Hyaluronidase activity was significantly higher in normal ovary (P < 0.05) and normal endometrium (P< 0.05) than in normal cervix. One dominant 65-kDa hyaluronidase was expressed in 100% (14 out of 14) of ovarian cancer tissues and in 91% (10 out of 11) of endometrial cancer tissues. However, hyaluronidase activity was not observed in cervical cancer tissues. Hyaluronidase activity was significantly higher in ovarian (P < 0.001) and endometrial (P < 0.01) cancer tissues than in cervical cancer tissue and was significantly higher in ovarian cancer tissue than in endometrial cancer tissue (P < 0.05). These facts suggest that the cancer cells make use of the original characteristic of the organ to invade and metastasize. Moreover, these results reflect the difference in metastatic forms and are suggestive of a strong relationship between hyaluronidase activity and invasion and metastasis of ovarian and endometrial cancers compared with cervical cancer.

  188. Clinical value of CA125, CA19-9, CEA, CA72-4, and TPA in borderline ovarian tumor. Reviewed

    Tamakoshi K, Kikkawa F, Shibata K, Tomoda K, Obata NH, Wakahara F, Tokuhashi Y, Ishikawa H, Kawai M, Tomoda Y.

    Gynecol Oncol.   Vol. 62 ( 1 ) page: 67-72   1996.7

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    Five tumor markers were analyzed clinically in 101 patients with borderline ovarian tumors who were treated by the Tokai Ovarian Tumor Study Group, an association comprising Nagoya University and its affiliated hospital, between January 1986 and December 1994. The positive rate of CA125 was 68.2% in serous tumor and 51.9% in mucinous tumor. The positive rate of CA19-9 was 51.5% in serous tumor and 44.7% in mucinous tumor. The positive rates and mean serum levels of CA125 in serous and mucinous tumor by stage had rising tendencies with an increase in each stage. The mean serum levels of CA19-9 in serous and mucinous tumor by stage had rising tendencies with an increase in each stage. CA125 and CA19-9 were useful for screening of borderline ovarian tumors. The positive rates of CEA and TPA in mucinous tumor were 32.5 and 27.3%, respectively, although none of the patients with serous tumor were positive in CEA and TPA. The positive rates and mean serum levels of CEA in mucinous tumor by stage had rising tendencies with an increase in each stage. The positive rate of CA72-4 was significantly lower than that of CA125 (P < 0.05).

  189. Characterization of extracellular matrix-degrading proteinase and its inhibitor in gynecologic cancer tissues with clinically different metastatic form. Reviewed

    Tamakoshi K, Kikkawa F, Nawa A, Ishikawa H, Mizuno K, Tamakoshi A, Yamagata S, Suganuma N, Tomoda Y.

    Cancer.   Vol. 76 ( 12 ) page: 2565-2571   1995.12

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    BACKGROUND. The authors conducted a comparison study of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) activities in clinically different metastatic types of ovarian cancer, cervical cancer, and endometrial cancer tissues. METHODS. Gelatinase activity in culture medium obtained from each cancer tissue was detected by zymography and was quantitated by densitometer. Tissue inhibitor of metalloproteinase-1 activity was measured in culture medium by the human TIMP-1 enzyme immunoassay kit. RESULTS. Six dominant gelatinases were detected in ovarian, cervical, and endometrial cancers: 200-kDa; 130-kDa; 92-kDa (MMP-9); 83-kDa, which is an active form of 92-kDa gelatinase; 72-kDa (MMP-2); and 66-kDa gelatinase, which is an active form of 72-kDa gelatinase. The 92-kDa and 72-kDa gelatinolytic bands were present in all samples. The expression rates of 200-, 130-, and 83-kDa gelatinase in endometrial cancer and cervical cancer tissues were higher than that observed in ovarian cancer tissue. Densitometric analysis showed that the 92-kDa/72-kDa ratio was significantly higher in cervical cancer tissue than in ovarian and endometrial cancer tissues (P < 0.05), and the 66-kDa/72-kDa ratio was significantly higher in endometrial cancer tissue than in ovarian cancer tissue (P < 0.01). Tissue inhibitor of metalloproteinase-1 activity was significantly lower in cervical cancer tissue than in ovarian and endometrial cancer tissues (P < 0.01). CONCLUSIONS. These results reflect the difference of metastatic forms and are indicative of the possibility of the strong relationship to MMP activity in the invasion and metastasis of cervical cancer and endometrial cancer, compared with those of ovarian cancer.

  190. Clinical value of a new serum tumor marker, CA125II, in gynecologic disease: comparison with CA125. Reviewed

    Tamakoshi K, Kikkawa F, Hasegawa N, Ishikawa H, Mizuno K, Kawai M, Tomoda Y.

    Gynecol Obstet Invest.   Vol. 39 ( 2 ) page: 125-129   1995

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    CA125 II, an improved version of the conventional CA125 was compared with CA125 as to which was more useful in gynecologic disease. In the diagnosis of tumors around the adnexal field (primary epithelial ovarian cancer, metastatic ovarian cancer, benign ovarian tumor and endometrial cyst), CA125 II showed the same sensitivity and specificity as CA125. CA125 II also has high simultaneous reproducibility in the low concentration area. The examination by the receiver operating characteristic curve revealed that CA125 II has higher precision than that of CA125 when it is used for the screening test. In conclusion, CA125 II is a better tumor marker than conventional CA125.

  191. Different pattern of zymography between human gynecologic normal and malignant tissues. Reviewed

    Tamakoshi K, Kikkawa F, Nawa A, Maeda O, Kawai M, Sugamuma N, Yamagata S, Tomoda Y.

    Am J Obstet Gynecol.   Vol. 171 ( 2 ) page: 478-484   1994.8

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    OBJECTIVE: Our purpose was to evaluate type IV collagenase in ovarian and endometrial cancer tissues. STUDY DESIGN: Tissue specimens were obtained from patients with ovarian and endometrial cancer and uterine myoma. Gelatinase activity was detected by zymography and quantitated by densitometer. RESULTS: Four dominant gelatinases were detected in ovarian and endometrial cancer tissues: 200, 130, 92, and 72 kd gelatinase. Other forms observed were 83 kd gelatinase, which is an active form of 92 kd gelatinase, and 66 kd gelatinase, which is an active form of 72 kd gelatinase. Densitometric analysis showed that the 92 kd/72 kd ratio in ovarian cancer tissues was significantly higher than in normal ovarian tissues (p < 0.05) and that the 66 kd/72 kd ratio was higher in ovarian cancer tissues (p = 0.07). Both ratios in endometrial cancer tissues were significantly higher than in normal endometrial tissues (p < 0.05). CONCLUSION: Gelatinase activity was remarkably higher in ovarian and endometrial cancer tissues. Especially, 92, 83, and 66 kd gelatinases were clearly detected in cancer tissues, suggesting that these gelatinases were related to the malignant phenotype, because degradation of the components of the basement membrane such as type IV collagen is necessary for cancer cells to metastasize.

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Books 2

  1. 乳幼児の発達医療と生育支援

    ( Role: Joint author)

    南山堂  2007.7 

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  2. エキスパート管理栄養士養成シリーズ 公衆衛生学 4章健康状態・疾病の測定と評価 1.疫学の概念

    ( Role: Joint author)

    化学同人  2004 

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    Language:Japanese

Presentations 34

  1. 出生数の変化に関連する因子の検討

    永井亜貴子,田中太一郎,松浦賢長,山崎嘉久,尾島俊之,玉腰浩司,市川香織,荒木田美香子,山縣然太朗

    第22回日本疫学会 

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    Event date: 2012.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  2. Association between CRP and Incidence of Type-2 Diabetes in a Japanese Worksite-based Cohort

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    Event date: 2012.1

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  3. 米国心臓学会が提唱する食事・栄養摂取指標と6年間の糖尿病発症との関連

    上村真由,八谷寛,玉腰浩司,豊嶋英明,大塚礼,李媛英,佐々木敏,青山温子

    第22回日本疫学会 

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    Event date: 2012.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  4. 在宅介護者の握力と筋・骨・関節に関連する症状の男女の特徴―非介護者との比較から―

    鈴木岸子,星野純子, 堀容子, 濱本律子,杉山晃子,玉腰浩司,近藤高明, 榊原久孝

    第21回日本疫学会学術総会 

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    Event date: 2011.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:札幌   Country:Japan  

  5. 子供の数と総死亡との関連:JACC Studyから

    玉腰暁子,玉腰浩司,林櫻松,三上春夫,稲葉裕,柳生聖子,菊池正悟

    第21回日本疫学会学術総会 

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    Language:Japanese   Presentation type:Poster presentation  

    Venue:札幌   Country:Japan  

  6. 次子の出産希望と妊娠・出産に関する満足度の関連の検討

    永井亜貴子, 田中太一郎, 松浦賢長, 山崎嘉久, 尾島俊之, 玉腰浩司, 荒木田美香子,市川香織, 山縣然太朗

    第21回日本疫学会学術総会 

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    Language:Japanese   Presentation type:Poster presentation  

    Venue:札幌   Country:Japan  

  7. H Magnetic Resonance Spectroscopeで測定した肝内脂質量とインスリン抵抗性の関連

    八谷寛,二橋尚志,王超辰,玉腰浩司,李媛英,大塚礼,堀田洋,松下邦洋

    第21回日本疫学会学術総会 

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    Event date: 2011.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:札幌   Country:Japan  

  8. EPDSによる産後うつ頻度の把握に関する研究

    鈴木茜, 樋口善之, 渡辺多恵子, 若松美貴代, 市川香織, 玉腰浩司, 松浦賢長

    第51回日本母性衛生学会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:金沢   Country:Japan  

  9. 在宅で介護している高齢な女性介護者の尿中ストレス関連物質に関する検討

    星野純子, 堀容子, 近藤高明, 玉腰浩司, 柴山健三, 宇佐美久枝, 小島重子, 榊原久孝, 豊嶋英明

    第69回日本公衆衛生学会総会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  10. 母子保健事業と健やか親子21評価指標の変化(第2報) 子どもの虐待、育児不安

    永井亜貴子, 田中太一郎, 松浦賢長, 山崎嘉久, 尾島俊之, 玉腰浩司, 市川香織, 荒木田美香子, 山縣然太朗

    第69回日本公衆衛生学会総会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京y   Country:Japan  

  11. 母子保健事業と健やか親子21評価指標の変化(第1報) 妊娠・出産、小児医療

    田中太一郎, 永井亜貴子, 松浦賢長, 山崎嘉久, 尾島俊之, 玉腰浩司, 市川香織, 荒木田美香子, 山縣然太朗

    第69回日本公衆衛生学会総会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  12. 健やか親子21の評価指標の変化(第2回) 中間評価の報告

    山縣然太朗, 松浦賢長, 山崎嘉久, 尾島俊之, 玉腰浩司, 市川香織, 荒木田美香子

    第69回日本公衆衛生学会総会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  13. いのちの尊さとすばらしさ 思春期を迎えて

    玉腰浩司

    思春期セミナー 

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    Event date: 2005.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  14. 極めて健康な成人男性におけるadiponectinとC反応性蛋白の関連

    松下邦洋, 八谷寛, 玉腰浩司, 室原豊明, 豊嶋英明

    第40回日本循環器病予防学会 

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    Event date: 2005.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  15. 生活習慣病の家族歴と罹患集積状況との関連

    和田恵子, 玉腰浩司, 大塚礼, 張惠明, 竹藤聖子, 松下邦洋, 杉浦嘉一郎, 八谷寛, 豊嶋英明

    第40回日本循環器病予防学会 

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    Event date: 2005.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  16. 食べる速さと現在のBMI,20歳からのBMI変化量との関連

    大塚礼, 玉腰浩司, 八谷寛, 和田恵子, 松下邦洋, 杉浦嘉一郎, 竹藤聖子, 歐陽はい, 張恵明, 村田千代栄, 豊嶋英明

    第40回日本循環器病予防学会 

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    Event date: 2005.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  17. 性感染症について

    玉腰浩司

    思春期セミナー 

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    Event date: 2005.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  18. 母子保健情報から読む地域の状況

    玉腰浩司,和田恵子

    平成16年度地域保健福祉教育情報ネットワーク構築事業 

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    Event date: 2005.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  19. どうして性が存在するのか

    玉腰浩司

    思春期教室 

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    Event date: 2005.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  20. 妊娠中の経過と喫煙予防について

    玉腰浩司

    思春期セミナー 

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    Event date: 2004.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  21. 飲酒と女性乳がん罹患リスクの関連

    林櫻松, 菊地正悟, 豊嶋英明, 玉腰浩司, 八谷寛, 若井建志, 鈴木貞夫, 西尾和子, 徳留信寛, 玉腰暁子, 柳生聖子, 小幡由紀

    第63回日本癌学会 

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    Event date: 2004.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  22. 生殖歴と乳がん罹患リスクとの関連

    玉腰浩司, 豊嶋英明, 若井建志, 林櫻松, 鈴木貞夫, 丹羽慶光, 西尾和子, 八谷寛, 徳留信寛, 玉腰暁子, 大規模コホート運営委員会

    第63回日本癌学会 

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    Event date: 2004.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  23. 血清IgEと大腸がんリスクとの関連 文科省科研費の補助による大規模コホート内症例対照研究

    鈴木康司, 伊藤宜則, 若井建志, 小嶋雅代, 玉腰浩司, 豊嶋英明, 渡邊能行, 早川式彦, 徳留信寛, 橋本修二, 鈴木貞夫, 小笹晃太郎, 玉腰暁子

    第63回日本癌学会 

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    Event date: 2004.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  24. 喫煙と卵巣癌罹患リスクの関連

    丹羽慶光, 西尾和子, 豊嶋英明, 玉腰浩司, 八谷寛, 林櫻松, 若井建志, 徳留信寛, 鈴木貞夫, 玉腰暁子

    第63回日本癌学会 

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    Event date: 2004.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  25. 脂質摂取と乳がん罹患リスクとの関連 日本における大規模コホート研究による検討

    若井建志, 玉腰浩司, 八谷寛, 鈴木貞夫, 徳留信寛, 丹羽慶光, 西尾和子, 林櫻松, 豊嶋英明, 玉腰暁子

    第63回日本癌学会 

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    Event date: 2004.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  26. アディポネクチンは肥満度,インスリン抵抗性とは独立にMetabolic Syndromeに関連する

    八谷寛, 玉腰浩司, 大塚礼, 近藤高明, 豊嶋英明

    第25回日本肥満学会 

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    Event date: 2004.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  27. 職域男性における自覚的ストレスと血清レプチン濃度との関連

    大塚礼, 八谷寛, 玉腰浩司, 堀容子, 長澤伸江, 近藤高明, 豊嶋英明

    第25回日本肥満学会 

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    Event date: 2004.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  28. 各種肥満指標をmetabolic syndrome関連徴候のスクリーニングに用いた場合の有用性

    近藤高明, 堀容子, 八谷寛, 玉腰浩司, 豊嶋英明

    第25回日本肥満学会 

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    Event date: 2004.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  29. 大豆製品摂取と乳がん罹患リスクとの関連

    西尾和子, 玉腰浩司, 八谷寛, 鈴木貞夫, 徳留信寛, 丹羽慶光, 林櫻松, 豊嶋英明, 若井建志, 玉腰暁子

    第63回日本癌学会 

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    Event date: 2004.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  30. 連携して地域の課題解決に臨む

    玉腰浩司

    平成16年度地域保健福祉教育情報ネットワーク構築事業 

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    Event date: 2004.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  31. 性と生から感染症を考える

    玉腰浩司

    思春期セミナー 

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    Event date: 2004.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  32. 職域コホートにおける血清レプチン濃度と生活習慣との関連

    大塚礼, 八谷寛, 玉腰浩司, 和田恵子, 堀容子, 近藤高明, 豊嶋英明

    第39回日本循環器病予防学会 

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    Event date: 2004.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  33. 職域集団における自己申告の身長,体重の妥当性

    和田恵子, 玉腰浩司, 間淵智子, 大塚礼, 村田千代栄, 張惠明, 石川美由紀, 八谷寛, 豊嶋英明

    第39回日本循環器病予防学会 

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    Event date: 2004.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  34. 濃い味の好みと肥満との関連性に関する検討

    堀容子, 大塚礼, 和田恵子, 八谷寛, 玉腰浩司, 近藤高明, 豊嶋英明

    第39回日本循環器病予防学会 

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    Event date: 2004.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

▼display all

Research Project for Joint Research, Competitive Funding, etc. 1

  1. 生活習慣病の病態解明と予防に向けての新たなアプローチ・胎児起源仮説の検証と発展

    2006

KAKENHI (Grants-in-Aid for Scientific Research) 16

  1. 経時データを用いたDOHaD仮説に基づく生活習慣病の疫学的病態解明

    Grant number:20K10496  2020.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    玉腰 浩司

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    本研究は、経時的なデータを用いて、出生時体重を胎内環境の指標としてその後の疾患発症との関連について生活習慣、DNAのメチル化等様々な視点から分析する。DOHaDの病態、即ち「発達期の環境の変化に対応した不可逆的な反応が生じると、発達が完了した時期の環境と合えば健康な生活ができ、そうでなければ成人期の様々な疾患の源になる」を疫学的に解明することは、母子から小児、成人、老年と続く生涯保健の向上に寄与する。
    平成9年から「生活習慣病とそれに続く心血管事故の予防を目的としたコホート研究」を行っており、平成25 年の調査時には1804名のDNAを同意の下保存した。また、同時に出生時体重や生活習慣病の既往歴を含む生活習慣アンケートを実施した。本研究では、糖尿病、高血圧、脂質代謝異常のいずれの既往歴も持たない517名(男性412名、女性105名、35歳から59歳、平均50.7±6.5歳)のDNAメチル化を測定した。ターゲットとした分子はATP-binding cassette protein G1(ABCG1)であり、この分子はHDLコレステロールの生成過程で重要な役割を果たしていることが知られている。また、ABCG1遺伝子のDNAメチル化が、心血管アテローム性動脈硬化症の早期徴候である頚動脈内膜中膜肥厚と関連するとの報告がある。2021年度は、胎内環境の指標である出生時体重とABCG1遺伝子のDNAメチル化率との関連を検討した。ABCG1遺伝子のDNAメチル化率(%)は、最小値50.9、25パーセンタイル値65.5、中央値68.3、75パーセンタイル値70.6、最大値83.3、平均値68.0、標準偏差3.9であった。出生時体重を2500グラム未満、2500グラム以上3000グラム未満、3000グラム以上に分けると、メチル化率の平均(標準偏差)は順に68.7(3.5)、67.7(4.1)、68.2(3.8)であった(一次の傾向性p値=0.849、二次の傾向性p値=0.093)。
    並行して、平成9年度からのデータの整理に努めた。
    保存したDNAを使って、生活習慣病に関連する遺伝子のメチル化について解析を進めている。2020年度はATP-binding cassette protein G1(ABCG1)に関して分析し、従来から研究を進めている出生時体重との関連を検討した。その結果、出生時体重が2500グラム未満の成人(35歳から59歳)では、DNAのメチル化率が高い傾向がみられた。
    引き続き、保存したDNAを使って、生活習慣病に関連する遺伝子のメチル化について解析を進めていく。2020年度はATP-binding cassette protein G1(ABCG1)に関して分析したが、さらに他の遺伝子のメチル化についても解析を進めていく。また、平成9年から「生活習慣病とそれに続く心血管事故の予防を目的としたコホート研究」において、集積しているデータを整理し、経時データとして分析できるデータセットの作成に努める。

  2. 周産期から取り組む母親の役割自信構築支援のための基礎的研究

    Grant number:19K11030  2019.4 - 2023.3

    科学研究費助成事業  基盤研究(C)

    高橋 由紀, 玉腰 浩司, 奈良間 美保

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    Authorship:Coinvestigator(s) 

    妊娠・出産は,女性にとって人生における喜ばしいライフイベントの1つであるが,産科合併症の増加や子育てのしにくさや抑うつ傾向を示す母親が増加している.国内においては,産後うつ病自己評価票を用いた早期スクリーニングが標準化した一方で,早期発見だけでは対応にも限界がある.わが国の産後ケアの特徴として,産後48時間以内に退院する諸外国と比較すれば長い入院期間がある.この時間的な利点を活かし,周産期ケアのあり方と産後の母親の身体的回復が母親役割の自信や育児ストレスにどのように関連しているのかについて検討し,具体的な産後の母親の役割適応を促進する助産実践につながる重要なエビデンスを提示したい.
    2020年度は、データ収集期間として位置付け、2020年1月より研究協力施設において妊婦に対する研究参加依頼および研究同意の確認、データ収集に着手した。しかし、新型コロナウイルス流行にともない、病院におけるデータ収集は4月に中断となり、その後研究再開には至らなかった。次年度以降の調査再開については不明な状態である。したがって、2020年度に収集できた件数は、研究参加同意者数97名、うち初産53名、経産婦44名である。そのうち、産後1か月時の追跡調査ができた対象者は90名、産後4か月の追跡調査ができた対象者は49名であった。
    これまでの研究成果の公表は以下の学会においておこなった。1.2020.3.22. 第34回日本助産学会学術集会(新潟)「褥婦が自覚する身体部痛と日常生活の支障感の産後1か月までの推移」2.2020.6.9. WAIMH 17th World Congress(BRISBANE)“Difficulties with daily life activities during early postpartum: relationship with postnatal depression at 1 month postpartum”3.2020.6.9. WAIMH 17th World Congress(BRISBANE)”Usage of mobile device during the first mother-infant interactions immediately after birth-a case report”国際学会については、新型コロナウイルス流行に伴い、学会開催が延期となり2021年6月にオンラインにポスター発表が決定している。
    新型コロナウイルス流行にともない、データ収集が中断し、再開の目途がたたないため、当初に予定していたデータ数の確保が難しいことが理由である。
    研究再開への努力を続けることと、現在データ収集が終了しているデータを用いて、解析を行い、成果の公表を行う。

  3. 退職公務員におけるフレイルと社会参加に関する在職時からのライフコース疫学研究

    Grant number:18H03057  2018.4 - 2022.3

    科学研究費助成事業  基盤研究(B)

    八谷 寛, 平川 仁尚, 李 媛英, 江 啓発, 市野 直浩, 太田 充彦, 山田 宏哉, 大塚 礼, 玉腰 浩司, 吉岡 健太郎, 内藤 久雄, 青山 温子, 上村 真由

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    Authorship:Coinvestigator(s) 

    本研究は、若年成人期・中年期の生活習慣や健康状態(健診成績)と高齢期の健康状態との関連を調べることを目的としており、2018年に退職者に対して、フレイルや認知機能の評価、腹部超音波、社会参加の状況の調査等を含む包括的な調査を実施した。2002年の血糖値と16年後の認知機能が負に関連することを見出した結果をJournal of Epidemiologyに原著論文として公表した。また、発症スクリーニングのための病歴自己申告調査と合わせて実施したJST版活動能力指標及び精神的健康に関する質問紙調査の2,289名の有効回答のデータベース化を今年度は完成し、退職後の生活習慣とともに統計解析を開始した。
    具体的な結果は以下の通りである。調査時60歳以上であった回答者2,215名のうち、1,893名(85%)が男性で、平均年齢は69.3(中央値70歳、範囲:60-83歳)、7.8%が独居、51.8%が二人世帯であった。JST版活動能力指標の新機器利用3点以上、情報収集4点以上、生活マネジメント4点以上、社会参加2点以上(JST版活動能力指標利用マニュアル第2版による100人中上位50位のカットオフ値)の割合は68.2%、38.1%、26.5%、70.8%であった。
    本研究では、研究ベースとなっている愛知職域コホート研究の在職者の生活習慣等の継続的な調査及び対象者の追跡調査を、継続して実施しており、在職者を対象に、病歴スクリーニング調査を実施した。これらの結果に基づき、糖尿病、急性冠血管疾患、脳卒中に関連する要因についての検討を継続して行った。
    本研究で具体的に実施する事項と計画した在職者調査と退職者調査をそれぞれ実施し、データベース化が完了した。また血液及びDNAの保存も計画通り実施できている。また本研究で明らかにすることを目的とした、若年成人期・中年期の生活習慣や危険因子の状況と退職後の健康状態との関連については、統計解析を継続して実施しているが、軽度認知障害発現リスクについて論文公表できた。また、退職公務員の生活の特徴ならびに在職中の要因との関連性についても統計解析を実施しており、概ね計画通りと考える。
    計画最終年度であり、研究計画において具体的に実施するとした各事項について、統計解析・論文公表を行っていく。また2020年度に実施した在職者に対する病歴スクリーニング調査結果に基づき、主治医に対する詳細な調査を実施する。さらに退職者に対する定期的な病歴自己申告調査を実施するとともに、生活習慣の変化についても確認する。

  4. 日本女性の妊娠期から産褥期の栄養が胎児期から新生児期・母乳に与える経世代的影響

    Grant number:17K12325  2017.4 - 2022.3

    科学研究費助成事業  基盤研究(C)

    田辺 圭子, 玉腰 浩司, 室月 淳, 高橋 由紀, 谷 純子

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    妊娠期の栄養は母体の健康を維持し,胎児を健やかに育てるために必要不可欠であり,この時期の胎内環境がのちの疾病や健康を決めるといっても過言ではない。特に,妊娠初期の栄養は正常な胎児発育において重要な役割を担っており,次世代の長期にわたる健康に寄与する。本研究は,成人病胎児期起源説の観点から,胎児期から新生児期にかけての栄養調査を実施した。昨年度,データ収集を終え,助産学会等で発表した。
    今年度も妊娠期の栄養を主として,つわりの影響の有無による比較(第61日本母性衛生学会学術集会「つわりの有無による妊娠期の女性の栄養摂取と食生活習慣」),BMI3群での比較(同学術集会「体型別にみる妊娠期の女性の栄養摂取と食生活習慣」)を発表した(ただし,コロナ禍のためオンライン)。現在,つわりの影響として発表したものを「つわりの程度にみる日本人女性の妊娠初期の栄養素等摂取状況」として母性衛生誌に投稿したところである。今回の解析より,本研究対象者はつわりの程度にかかわらず妊娠初期の食事摂取基準を充たしていない栄養素が多いことがわかった。そのため,妊娠初期の栄養指導は,つわりの影響に配慮しつつも次世代の健康に影響することを念頭に,従来からの栄養指導を見直し,妊娠初期から十分な栄養素等の摂取を促していく栄養指導への転換が必要であると考えられた。
    また,2020年度,延期となったICM学会が今年度はバーチャルによる開催が決定した。一昨年採択されたポスター発表(「Association between nutrition status and morning sickness in Japanese pregnant women」)がようやく実現することなり,再解析し,ポスターを作成している。
    今後、体型別による比較を論文化していく予定である。
    データセットが完了し,現在、一部の分析が進み,学会発表や論文投稿が可能となっているため。ただし,まだ妊娠期の栄養も食品群までの詳細な解析に至っていないこと,妊娠経過や分娩経過との関連まで進んでいないため,おおむね順調と判断した。
    現在,ようやく,妊娠初期の特徴がつかめてきたところである。これから,妊娠食・中期・末期,産褥期とどのように栄養素等摂取状況が変化していくのか,体型別にみた場合の特徴など把握していきたい。本研究の目的は、胎内環境や母乳成分への妊娠期の栄養がどのように関連するのか,さらに,それらを踏まえて妊娠期の適切な栄養指導を考えることである。妊娠期はこれまでの食事内容や食生活行動を見直すきっかけとなる時期である。低栄養による母児の低体重化を予防することは、世代間連鎖を断ち切るだけでなく、成人期までの望ましい食生活習慣獲得に寄与すると考える。

  5. Care for patients with both diabetes and secondary lymphedema

    Grant number:16H05563  2016.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    FUJIMOTO Etsuko

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    We attempted to establish a care program for breast cancer-related lymphedema in diabetic patients. We examined from various viewpoints based on the complete decongestive therapy (CDT).
    MR images of the forearm revealed that fluid accumulates in ulnar side more than radial side. Therefore, it is recommended that the drainage should focus on this part. After 120 minutes of meal, it was found that blood pressure stabilize. Hence CDT should be carried out at 120 minutes after a meal. Because the evaluation using a tape measure or subjective symptoms was not sufficient, in order to understand the situation of edema, magnetic resonance imaging or ultrasonic diagnostic imaging is necessary. In self-care, it is important to visually grasp the effects of care in order to encourage patients. For this purpose, we considered to use a 3D scanner.

  6. エピジェネティクス理論に基づいて生活習慣病の起源を疫学的に探究する

    2015.4

    科学研究費補助金  基盤研究(C)

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  7. Epidemiological study on the origin of lifestyle-related diseases based on epigenetic theory

    Grant number:15K08802  2015.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Tamakoshi Koji

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    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    Among 421 men (mean 50.7 ± 6.1 years) who had no history of diabetes, hypertension, or abnormal lipid metabolism, the association between birth weight and the methylation of the ATP-binding cassette protein A1 (ABCA1) gene was examined to elucidate the epidemiological pathology of lifestyle-related diseases based on epigenetics theory. The ATP-binding cassette protein A1 (ABCA1) plays an important role in HDL cholesterol production. The methylation rate of DNA was significantly higher in the group of less than 2500 g compared to the group of 2500 g or more among the subjects at age 50 and older, while there was no significant difference between the two groups among those under the age of 50. This finding suggests that the bad prenatal environment may promote the DNA methylation rate of ABCA1 gene in the second half of adulthood.

  8. Interdisciplinary study of obstetric management and gynecological rare tumor in Vietnam

    Grant number:15H02660  2015.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    FUMITAKA KIKKAWA

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    For the purpose of not only the development of obstetrics and gynecology in Vietnam, but also creation of evidence worldwide and building of medical research resources to Japan, we investigated obstetric management and gynecological rare tumor in Vietnam at several facilities in Vietnam. In the present study, several findings, which are related to improvement of mothers and children's prognosis,were gained. First, Pregnancy with dengue fever causes thrombocytopenia, which is at risk of postpartum hemorrhage. Second, cesarean section scar pregnancy with an increase in cesarean section rate in Vietnam, could be managed by medication for only selected patients. Third, evaluation of cardiac function by ultrasound examination for fetal growth restriction would be beneficial. Lastly, we found that there was a high secondary rate after molar pregnancy in Vietnam and preventive measures might improve it.

  9. Spatial and genetic epidemiological study on the pathogenesis of obesity and diabetes

    Grant number:26293153  2014.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Yatsuya Hiroshi, HANIBUCHI Tomoya, TOYOSHIMA Hideaki, CHIANG Chifa, YAMASHITA Kentaro, WANG Chaochen, ZHANG Yan, KANEKO Kayo, AL-SHOAIBI Abubakr Ahmed Abdullah, GEBREMARIAM Lemlem Weldegerima, HE Yupeng, SUZUKI Koji, SAYEED Shurovi, KATOH Yoshiji, FUJISAWA Akiko, MATSUNAGA Masaaki, KHINE May Thet

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    The associations of a neighborhood’s built environment on health via its effects on physical activity, diet, or other unknown mediators have been suggested, but little studied in Japan. A composite measure of geographic characteristics, walkability index, was obtained in the present study using geographic information system (GIS), which consists of population density, road density, access to parks, and access to retail areas (Hanibuchi, et al., 2015). As the results, the degree of residence neighborhood walkability was associated with self-reported leisure-time physical activities among workers living in an urban-suburban area. Also, distance between one's home and the workplace was positively associated with self-reported duration of walking.

  10. Longitudinal study of cardiovascular multi-biomarkers in long-time workers.

    Grant number:25460795  2013.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Hirai Makoto

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    Long-time working increases cardiovascular diseases even in young workers. However, the mechanisms for this have not yet been elucidated. We analyzed biomarkers to clarify the pathobiochemical mechanisms involved in the development of cardiovascular diseases induced by long-time working in office and factory workers. We measured the followings twice (1-year interval): small dense (SD) low-density lipoprotein (LDL); total cholesterol; LDL cholesterol; high-density lipoprotein cholesterol. We also used questionnaires concerning smoking habit and body weight gain or loss time twice with 1-year interval. In smokers with overtime work, SD-LDL and the ratio of SD-LDL to LDL significantly increased however, LDL did not change significantly. In non-smokers with overtime work, only the ratio of SD-LDL to LDL increased significantly. Lowering SD-LDL might be of importance and beneficial in preventing cardiovascular events in office and factory workers with long-time working.

  11. 胎児期起源仮説に基づく生活習慣病予防―実践に向けてのエビデンス創生―      

    2008

    科学研究費補助金  基盤研究(C),課題番号:20590641

    玉腰 浩司

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  12. 癌の転移・浸潤抑制物質の同定およびクローニング

    1996 - 1997

    科学研究費補助金  基盤研究(C)

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  13. 婦人科癌転移阻止剤開発へのアプローチ

    1995

    科学研究費補助金  奨励研究(A)

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  14. シスプラチン耐性に関与する蛋白、遺伝子の同定及びクローニング

    1994 - 1996

    科学研究費補助金  基盤研究(C)

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  15. 悪性卵巣腫瘍の再発防止による長期生存率改善の研究

    1994 - 1996

    科学研究費補助金  基盤研究(B)

  16. 非免疫系抗腫瘍性因子による新たな卵巣癌治療法開発への基礎的検討に関する研究

    1994 - 1995

    科学研究費補助金  基盤研究(C)

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