Updated on 2024/10/22

写真a

 
NAGANAWA, Shinji
 
Organization
Graduate School of Medicine Program in Integrated Medicine Advanced Medical Science Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
Contact information
メールアドレス

Degree 1

  1. Doctor of Medicine ( 1998.3   Nagoya University ) 

Research Interests 4

  1. magnetic resonance imaging, functional brain imaging, diffusion weighted image, inner ear

  2. magnetic resonance imaging endolymphatic hydrops glymphatic system

  3. inner ear

  4. functional brain imaging

Research Areas 2

  1. Others / Others  / Radiation Science

  2. Life Science / Radiological sciences

Current Research Project and SDGs 1

  1. Study on high resolution MRI of the inner ear

Research History 5

  1. Nagoya University   Brain and Mind Research Center   Director in General

    2015.4 - 2019.3

  2. Nagoya University

    2007.4

  3. Nagoya University

    2006.7

  4. Nagoya University   Professor

    2006.7

  5. Nagoya University

    2006.7

Education 1

  1. Nagoya University   Faculty of Medicine

    - 1987

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    Country: Japan

Professional Memberships 11

  1. 日本医学放射線学会   理事

    2016.4

  2. 日本磁気共鳴医学会   代議員

    2019.4 - 2021.9

  3. 日本医学放射線学会   代議員

    2010.4 - 2022.3

  4. Radiological Society of North America

  5. International Society of Magnetic Resonance in Medicine

  6. 日独放射線医学交流計画   代表幹事 (日本側)

    2018.9

  7. International Society of Magnetic Resonance in Medicine

  8. 日本医学放射線学会

  9. 日本磁気共鳴医学会

  10. 日本医学放射線学会

  11. Radiological Society of North America

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Committee Memberships 1

  1.   安全保障委員  

       

Awards 32

  1. 感謝状 (国内招待講演 メニエール病の画像診断;小さな宇宙を究める)

    2024.10   第34回日本耳科学会総会・学術講演会  

    長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  2. 2024年度日本磁気共鳴医学会 優秀論文賞

    2024.9   一般社団法人 日本磁気共鳴医学会  

    長縄慎二

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  3. 2023 MRMS Most Valuable Reviewer

    2024.9  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  4. 放射線科専門医30年の功績に対しての感謝状

    2023.11   日本放射線科専門医会・医会  

    長縄慎二

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    Country:Japan

  5. 感謝状

    2022.11   第81回日本めまい平衡医学会総会・学術講演会   感謝状

    長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc. 

  6. 2021 MRMS Distinguished Reviewer

    2022.9  

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    Award type:Honored in official journal of a scientific society, scientific journal 

  7. 2020 MRMS Distinguished Reviewer

    2021.10   2020 MRMS Distinguished Reviewer

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    Award type:Honored in official journal of a scientific society, scientific journal 

  8. MRMS(Magnetic Resonance in Medical Sciences) 創刊20周年最優秀論文賞

    2021.9   (一社) 日本磁気共鳴医学会  

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    Award type:Honored in official journal of a scientific society, scientific journal 

  9. 日本磁気共鳴医学会優秀論文賞

    2021.9   (一社) 日本磁気共鳴医学会  

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    Award type:Award from Japanese society, conference, symposium, etc. 

  10. 2020 ISMRM (International Society for Magnetic Resonance in Medicine) Fellows of the Society (senior fellow)

    2020.8   ISMRM virtual conference  

    Shinji Naganawa

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    Award type:International academic award (Japan or overseas)  Country:Japan

  11. MAGNA CUM LAUDE Radiographer Poster Award

    2019.2   European Conference of Radiology (ECR) 2019   Assessment of the severity in chronic thromboembolic pulmonary hypertension by quantitative parameters of dual-energy CT.

    Yoshinori Tsutsumi, Shingo Iwano, Naoki Okumura, Shiro Adachi, Shinji Abe, Takahisa Kondo, Shinji Naganawa, Katsuhiko Kato

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    Award type:Award from international society, conference, symposium, etc.  Country:Austria

  12. 一般社団法人日本めまい平衡医学会 60周年記念理事長表彰

    2018.11   一般社団法人日本めまい平衡医学会  

    長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  13. 2018年度日本磁気共鳴医学会優秀論文賞

    2018.9   一般社団法人 日本磁気共鳴医学会  

    長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  14. 平成28年度Japanese Journal of Radiology、Most often cited papers

    2017.4   公益社団法人日本医学放射線学会  

    長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  15. JJR Excellent Reviewer Award in 2015

    2016.4  

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    Country:Japan

  16. 第45回日本神経放射線学会 優秀症例展示賞(眼球内シリコンオイルの頭蓋内迷入の2例)

    2016.2   第45回日本神経放射線学会   (眼球内シリコンオイルの頭蓋内迷入の2例)

    川井 恒、田岡俊昭、中根俊樹、櫻井康雄、佐竹弘子、長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc. 

  17. 第45回日本神経放射線学会 最優秀口演賞(「Glioblastomaらしさ」とは何か?:テクスチャ解析による定量の試み)

    2016.2   第45回日本神経放射線学会   「Glioblastomaらしさ」とは何か?:テクスチャ解析による定量の試み

    田岡俊昭、川井 恒、中根俊樹、長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc. 

  18. Certificate of Merit

    2015.12   RSNA  

    Toshiaki Taoka, Akio Fukusumi, Toshiteru Miyasaka, Takeshi Wada, Kimihiko Kichikawa, Shinji Naganawa, Tomoko Ochi, Hisashi Kawai

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    Award type:International academic award (Japan or overseas)  Country:United States

  19. BEST ORAL PRESENTATION IN AOCMP 2015

    2015.11   15th Asia-Oceania Congress of Medical Physics  

    Takeshi Kamomae, Masataka Oita, Naoki Hayashi, Motoharu Sasaki, Hideki Aoyama, Yoshiyuki Itoh, Shinji Naganawa

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    Country:Japan

  20. 2014 MRMS Distinguished Reviewer Award

    2015.9  

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    Country:Japan

  21. 第74回日本医学放射線学会総会CyPos賞

    2015.4   第74回日本医学放射線学会総会  

    久保田誠司、伊藤善之、副松由加、野本由人、村尾豪之、山川耕二、石原俊一、平澤直樹、浅野晶子、長縄慎二

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    Country:Japan

    久保田誠司、伊藤善之、副松由加、野本由人、村尾豪之、山川耕二、 石原俊一、平澤直樹、浅野晶子、長縄慎二     I期声門癌に対する1回2.25Gyを用いた寡分割照射例の多施設調査

  22. 第10回「画像診断」Best Invited Editor賞

    2014.4   秀潤社  

    長縄慎二

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    Country:Japan

  23. 13th Asia-Oceania Congress of Medical Physics & 11th South-East Asian Congress of Medical Physics,Best Poster Award(Radiotherapy)

    2013.12   13th Asia-Oceania Congress of Medical Physics & 11th South-East Asian Congress of Medical Physics  

    Takeshi Kamomae, Yoshiyuki Itoh, Kuniyasu Okudaira, Masashi Tomida, Takayoshi Nakaya, Yoshikazu Miyake, Hiroshi Oguchi, Masataka Komori, Tohru Okada, Shinji Naganawa

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    Country:Singapore

  24. 2012 Robert and Elma Kemp Harper Prize

    2013.10   Clinical Radiology  

    Hiroshi Ogawa, Shigeki Itoh, Tetsuro Nagasaka, Kojiro Suzuki, Toyohiro Ota, Shinji Naganawa

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    Country:United Kingdom

  25. 第72回日本医学放射線学会総会 教育展示優秀賞

    2013.4   日本医学放射線学会  

    長縄慎二、山崎雅弘、川井 恒、中島 務

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    Country:Japan

    Objective diagnosis of Meniere´s disease by clinically applicable method:How to do it メニエール病のMRIによる簡便な客観診断法;How to do it

  26. BEST POSTER ON OTOLOGY,NEURO OTOLOGY AND SKULL BASE SURGERY

    2009.6  

    Tsutomu Nakashima, Shinji Naganawa, Naomi Katayama, Masaki Teranishi, Seiichi Nakata, Makoto Sugihara, Michihiko Sone, Sachiko Kasai, Mayumi Yoshioka, Masako Yamamoto, Tadao Yoshida, Hirokazu Suzuki

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    Award type:Award from international society, conference, symposium, etc. 

  27. certificate of merit

    2008.11   RSNA2008  

  28. Gold medal (日本医学放射線学会)

    2008.4   日本医学放射線学会  

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    Country:Japan

  29. Gold medal

    2007.4  

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    Country:Japan

  30. certificate of merit(ヨーロッパ放射線学会)

    2004.3   European Congress of Radiology  

  31. Cum Laude(北米放射線学会)

    1996  

  32. certificate of appreciation(ヨ-ロッパ放射線学会)

    1995  

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Papers 764

  1. Correlation of Endolysmphatic Duct Signal Intensity With Clinical Features in Otological Diseases. Reviewed

    Matsui K, Yoshida T, Sugimoto S, Kobayashi M, Naganawa S, Sone M

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   Vol. 45 ( 9 ) page: e624 - e629   2024.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MAO.0000000000004309

    PubMed

  2. Perilymphatic enhancement and endolymphatic hydrops: MRI findings and clinical associations. Reviewed

    Kobayashi M, Yoshida T, Fukunaga Y, Hara D, Naganawa S, Sone M

    Laryngoscope investigative otolaryngology   Vol. 9 ( 5 ) page: e1312   2024.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/lio2.1312

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  3. Comparing Lesion Conspicuity and ADC Reliability in High-resolution Diffusion-weighted Imaging of the Breast. Reviewed

    Iima M, Nakayama R, Kataoka M, Otikovs M, Nissan N, Frydman L, Urushibata Y, Honda M, Okazawa A, Satake H, Naganawa S, Nakamoto Y

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2024.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2463/mrms.tn.2024-0089

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  4. Visualization of distribution in the vitreous cavity via eye drops using ultra-heavily T2-weighted sequences in MRI: a preliminary study with enucleated pig eyes. Reviewed

    Kato Y, Yuki K, Nishiguchi K, Naganawa S

    Radiological physics and technology   Vol. 17 ( 3 ) page: 715 - 724   2024.9

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12194-024-00826-6

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  5. Correlation between the thyroid computed tomography value and thyroid function in hyperthyroidism: a retrospective study. Reviewed

    Iwanaga H, Fujita N, Abe S, Naganawa S, Kato K

    Annals of nuclear medicine   Vol. 38 ( 8 ) page: 659 - 665   2024.8

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    DOI: 10.1007/s12149-024-01938-0

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  6. The current state and future perspectives of radiotherapy for cervical cancer. Reviewed

    Yamada T, Kawamura M, Oie Y, Kozai Y, Okumura M, Nagai N, Yanagi Y, Nimura K, Ishihara S, Naganawa S

    The journal of obstetrics and gynaecology research     2024.6

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.15998

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  7. Predictive Performance of Radiomic Features Extracted from Breast MR Imaging in Postoperative Upgrading of Ductal Carcinoma in Situ to Invasive Carcinoma. Reviewed

    Satake H, Kinoshita F, Ishigaki S, Kato K, Jo Y, Shimada S, Masuda N, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2024.5

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2463/mrms.mp.2023-0168

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  8. Efficacy of 100 hz sound stimulation on saccular dysfunction in meniere's disease. Reviewed

    Sone M, Ohgami N, Katayama N, Kobayashi M, Gu Y, Tong K, Yoshida T, Naganawa S, Kato M

    Acta oto-laryngologica   Vol. 144 ( 4 ) page: 272 - 276   2024.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/00016489.2024.2363462

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  9. Development of automatic generation system for lung nodule finding descriptions Reviewed

    Momoki, Y; Ichinose, A; Nakamura, K; Iwano, S; Kamiya, S; Yamada, K; Naganawa, S

    PLOS ONE   Vol. 19 ( 3 ) page: e0300325   2024.3

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0300325

    Web of Science

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  10. Clinical significance of posterior expansion of the utricular endolymphatic space. Reviewed

    Kaida H, Yoshida T, Sugimoto S, Kobayashi M, Naganawa S, Sone M

    Acta oto-laryngologica   Vol. 144 ( 2 ) page: 107 - 111   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/00016489.2024.2329783

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  11. Response to "Striking a balance: embracing LLMs while upholding scientific integrity". Reviewed

    Nakaura T, Naganawa S

    Japanese journal of radiology   Vol. 42 ( 2 ) page: 210 - 211   2024.2

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11604-023-01498-9

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  12. Improvement of vertigo symptoms and acoustic power absorbance in cases with endolymphatic hydrops Reviewed

    Kobayashi, M; Yoshida, T; Fukunaga, Y; Hara, D; Sugimoto, S; Naganawa, S; Sone, M

    LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY   Vol. 9 ( 1 ) page: e1210   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/lio2.1210

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  13. Verifying the Accuracy of Hemodynamic Analysis Using High Spatial Resolution 3D Phase-contrast MR Imaging on a 7T MR System: Comparison with a 3T System. Reviewed

    Tajima S, Isoda H, Fukunaga M, Komori Y, Naganawa S, Sadato N

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2463/mrms.mp.2023-0016

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  14. Disruption of the Blood-Perilymph Barrier Preceding Endolymphatic Hydrops Formation in Meniere's Disease Reviewed

    Kobayashi, M; Yoshida, T; Sugimoto, S; Naganawa, S; Sone, M

    OTOLOGY & NEUROTOLOGY   Vol. 44 ( 10 ) page: E766 - E767   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MAO.0000000000003981

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  15. Shifting-field-of-view technique enhancing the inflow effect for identifying tumor/vessel boundaries in MRI for radiotherapy treatment planning. Reviewed

    Kato Y, Okudaira K, Noguchi Y, Kawamura M, Ishihara S, Naganawa S

    Radiological physics and technology   Vol. 16 ( 4 ) page: 578 - 583   2023.12

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12194-023-00745-y

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  16. New trend in artificial intelligence-based assistive technology for thoracic imaging Reviewed

    Yanagawa, M; Ito, R; Nozaki, T; Fujioka, T; Yamada, A; Fujita, S; Kamagata, K; Fushimi, Y; Tsuboyama, T; Matsui, Y; Tatsugami, F; Kawamura, M; Ueda, D; Fujima, N; Nakaura, T; Hirata, K; Naganawa, S

        2023.8

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11547-023-01691

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  17. Fluid signal suppression characteristics of 3D-FLAIR with a T2 selective inversion pulse in the skull base Reviewed

    Naganawa, S; Kato, Y; Yoshida, T; Sone, M

    NATURE COMMUNICATIONS   Vol. 14 ( 1 ) page: 4915   2023.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-023-40507-3

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  18. Urethral identification using three-dimensional magnetic resonance imaging and interfraction urethral motion evaluation for prostate stereotactic body radiotherapy Reviewed

    Kato, Y; Okumiya, S; Okudaira, K; Ito, J; Kumagai, M; Kamomae, T; Noguchi, Y; Kawamura, M; Ishihara, S; Naganawa, S

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 3 ) page: 504 - 517   2023.8

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.85.3.504

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  19. Effect of Temporal Sampling Rate on Estimates of the Perfusion Parameters for Patients with Moyamoya Disease Assessed with Simultaneous Multislice Dynamic Susceptibility Contrast-enhanced MR Imaging Reviewed

    Takamura, T; Hara, S; Nariai, T; Ikenouchi, Y; Suzuki, M; Taoka, T; Ida, M; Ishigame, K; Hori, M; Sato, K; Kamagata, K; Kumamaru, K; Oishi, H; Okamoto, S; Araki, Y; Uda, K; Miyajima, M; Maehara, T; Inaji, M; Tanaka, Y; Naganawa, S; Kawai, H; Nakane, T; Tsurushima, Y; Onodera, T; Nojiri, S; Aoki, S

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 22 ( 3 ) page: 301 - 312   2023.7

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    DOI: 10.2463/mrms.mp.2021-0162

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  20. Writing medical papers using large-scale language models: a perspective from the Japanese Journal of Radiology Reviewed

    Nakaura, T; Naganawa, S

    JAPANESE JOURNAL OF RADIOLOGY   Vol. 41 ( 5 ) page: 457 - 458   2023.5

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11604-023-01408-z

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  21. Magnetic resonance imaging of endolymphatic hydrops: a comparison of methods with and without gadolinium-based contrast agent administration Reviewed

    Ohashi, T; Naganawa, S; Nasu, Y; Kuno, K; Kato, K

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 2 ) page: 299 - 309   2023.5

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    DOI: 10.18999/nagjms.85.2.299

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  22. Significance of an augmented response on cervical vestibular evoked myogenic potential testing in Meniere's disease Reviewed

    Kobayashi, M; Katayama, N; Yoshida, T; Sugimoto, S; Naganawa, S; Sone, M

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 2 ) page: 375 - 379   2023.5

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    DOI: 10.18999/nagjms.85.2.375

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  23. Optimized radiotherapy treatment strategy for early glottic carcinoma Reviewed

    Ono, T; Itoh, Y; Ishihara, S; Kawamura, M; Oie, Y; Takase, Y; Okumura, M; Oyoshi, H; Nagai, N; Naganawa, S

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 2 ) page: 241 - 254   2023.5

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    DOI: 10.18999/nagjms.85.2.241

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  24. Retrospective study of cervical cancer with radiation dose reduction in concurrent chemoradiotherapy Reviewed

    Nagai, N; Kawamura, M; Ishihara, S; Oie, Y; Kozai, Y; Takase, Y; Okumura, M; Shindo, Y; Yasui, R; Yanagi, Y; Naganawa, S

    RADIOTHERAPY AND ONCOLOGY   Vol. 182   page: S1921 - S1922   2023.5

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  25. Pathophysiological analysis of idiopathic sudden sensorineural hearing loss by magnetic resonance imaging: A mini scoping review Reviewed

    Sone, M; Kobayashi, M; Yoshida, T; Naganawa, S

    FRONTIERS IN NEUROLOGY   Vol. 14   page: 1193104   2023.4

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    DOI: 10.3389/fneur.2023.1193104

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  26. Labyrinthine calcification in ears with otitis media and antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV): A report of two cases Reviewed

    Yoshida Tadao, Kobayashi Masumi, Sugimoto Satofumi, Naganawa Shinji, Sone Michihiko

    AURIS NASUS LARYNX   Vol. 50 ( 2 ) page: 299 - 304   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.anl.2022.01.0040385-8146

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  27. Presence of endolymphatic hydrops on listening difficulties in patients with normal hearing level Reviewed

    Yoshida, T; Kobayashi, M; Sugimoto, S; Fukunaga, Y; Hara, D; Naganawa, S; Sone, M

    ACTA OTO-LARYNGOLOGICA   Vol. 143 ( 2 ) page: 163 - 169   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/00016489.2023.2182450

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  28. Impact of endolymphatic hydrops on DPOAE in subjects with normal to mild hearing loss Reviewed

    Inagaki, K; Yoshida, T; Kobayashi, M; Sugimoto, S; Fukunaga, Y; Hara, D; Naganawa, S; Sone, M

    LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY   Vol. 8 ( 1 ) page: 262 - 268   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/lio2.998

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  29. Endoscopic Findings and Treatment of Gastric Neoplasms in Familial Adenomatous Polyposis Reviewed

    Sato Chihiro, Takahashi Kazuya, Sato Hiroki, Naruse Takumi, Nakajima Nao, Takatsuna Masafumi, Mizuno Ken-ichi, Hashimoto Satoru, Takeuchi Manabu, Yokoyama Junji, Kobayashi Masaaki, Terai Shuji

    JOURNAL OF GASTRIC CANCER   Vol. 22 ( 4 ) page: 381 - 394   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5230/jgc.2022.22.e30

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  30. Methods for confirming the safety of radiation therapy in patients with left ventricular assist device: a case of extranodal NK/T-cell lymphoma, nasal type Reviewed

    Oishi, H; Kondo, T; Kawamura, M; Shimada, K; Mutsuga, M; Kurokawa, T; Kuwayama, T; Hiraiwa, H; Morimoto, R; Okumura, T; Nishida, T; Kiyoi, H; Naganawa, S; Usui, A; Murohara, T

    JOURNAL OF ARTIFICIAL ORGANS   Vol. 25 ( 3 ) page: 274 - 278   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10047-022-01312-9

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  32. Pathological significance and classification of endolymphatic hydrops in otological disorders Reviewed

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  33. The Impact of System-Related Magnetic Resonance Imaging Geometric Distortion in Stereotactic Radiotherapy: A Case Report Reviewed

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  34. Novel approach to semi-quantification of tracer accumulation in dopamine transporter scan Reviewed

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  35. Functional connector hubs in the cerebellum. Reviewed

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  36. Consensus on MR Imaging of Endolymphatic Hydrops in Patients With Suspected Hydropic Ear Disease (Meniere)

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  37. Editorial: Hydropic Ear Disease: Imaging and Functional Evaluation Reviewed

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  38. End-Systolic Eccentricity Index Obtained by Enhanced Computed Tomography Is a Predictor of Pulmonary Vascular Resistance in Patients with Chronic Thromboembolic Pulmonary Hypertension. Reviewed

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  39. Poor local control of ulcerative T1 glottic cancer treated with 2.25-Gy per fraction radiotherapy Reviewed

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  40. Can we safely lower the RT dose with the use of high dose PF for advanced cervical cancer? Reviewed

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  43. A phase I/II trial of intraoperative breast radiotherapy in an Asian population: 10-year results Reviewed

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N., Moultos Othonas A., Mukherjee Maheswari, Nakayama Kazuhiko, Narayan Edward, Navaratnarajah, Neumann Philipp-Alexander, Nie Jiyun, Nie Yingjiu, Niemeyer Frank, Fiona, Nwaiwu Ogueri, Oldenmenger Wendy H., Olumayede Emmanuel, Ou Jianhong, Pallebage-Gamarallage Menuka, Pearce Simon P., Pelkonen Tuula, Pelleri Maria C., Pereira Joana L., Pheko Mpho, Pinto Karina A., Piovesan Allison, Pluess Michael, Podolsky Illya M., Prescott Julie, Qi Dongchen, Qi Xingshun, Raikou Vaia D., Ranft Andreas, Rhodes Johanna, Rotge Jean-Yves, Rowe Anna D., Saggar Manish, Schuon Robert A., Shahid Shaouli, Shalchyan Vahid, Shirvalkar Prasad, Shiryayev Oleg, Singh Jugpreet, Smout Michael J., Soares Antonio, Song Chunjiao, Srivastava Kshitij, Srivastava Rupesh K., Sun Jim, Szabo Attila, Szymanski Wiktor, Tai Chan N. P., Takeuchi Hisashi, Tanadini-Lang S., Tang Fei, Tao Wanyin, Theron G., Tian Chang F., Tian Yu-Shi, Tuttle Lisa M., Valenti Anna, Verlot Pierre, Walker Mirella, Wang Jun, Welter Danielle, Winslade Matthew, Wu Dalei, Wu Yi-Rui, Xiao Han, Xu Beisi, Xu Juan, Xu Ziyue, Yang Dongdong, Yang Mingjun, Yankilevich Patricio, You Yuyi, Yu Chenglong, Zhan Jian, Zhang Gong, Zhang Kai, Zhang Tuo, Zhang Yi, Zhao Guoyan, Zhao Jing, Zhou Xiaofan, Zhu Zhenxing, Ajani Penelope A., Anazodo Udunna C., Bagloee Saeed A., Bail Kasia, Bar Ido, Bathelt Joe, Benkeser David, Bernier Meghan L., Blanchard Adam M., Boakye Dominic W., Bonatsos Vasileios, Boon Michele H., Bouboulis George, Bromfield Elizabeth, Brown Joshua, Bul Kim C. M., Burton Kathryn J., Butkowski Eugene G., Carroll Grace, Chao Fengqing, Charrier Elisabeth E., Chen Xiaoyin, Chen Yu-Chih, Chenguang, Choi Jane R., Christoffersen Tore, Comel Joao C., Cosse Cyril, Cui Yanru, van Dessel Pieter, Dhaval, Diodato Daria, Duffey Maelle, Dutt Avik, Egea Luis G., El-Said Mohammed, Faye Martin, Fernandez-Fernandez Beatriz, Foley Kieran G., Founou Luria L., Fu Fan, Gadelkareem Rabea A., Galimov Evgeny, Garip Gulcan, Gemmill Alison, Gouil Quentin, Grey James, Gridneva Zoya, Grothe Michel J., Grebert Theophile, Guerrero Fabricio, Guignard Leo, Haenssgen Marco J., Hasler David, Holgate Joan Y., Huang Ancheng, Hulse-Kemp Amanda M., Jean-Quartier Claire, Jeon Sang-Min, Jia Yangyang, Jutzeler Catherine, Kalatzis Panagiotis, Karim Masud, Karsay Kathrin, Keitel Anne, Kempe Andreas, Keown Jeremy R., Khoo Chin M., Khwaja Nyil, Kievit Rogier A., Kosanic Aleksandra, Koutoukidis Dimitrios A., Kramer Paul, Kumar Dilip, Kirag Nukhet, Lanza Giuseppe, Le Thuc D., Leem Jung W., Leightley Daniel, Leite Andreia, Lercher Lukas, Li Ying, Lim Renly, Lima Luiz R. A., Lin Li, Ling Tong, Liu Yuchen, Liu Zhonghua, Lu Yao, Lum Fok M., Luo Hang, Machhi Jatin, Macleod Angus, Macwan Isaac, Madala Hanumantha R., Madani Nima, de Maio Nicola, Makowiecki Kalina, Mallinson Daniel J., Margelyte Ruta, Maria Caracausi, Markonis Y., Marsili Luca, Mavoa Suzanne, McWilliams Lorna, Megersa Moa, Mendes Caetano S. M., Menichetti Julia, Mercieca-Bebber Rebecca, Miller Jack J., Minde David-Paul M., Minges Alexander, Mishra Eleanor, Mishra Virendra R., Moores Carly, Morrice Nicola, Moskalensky Alexander E., Navarin Nicolo, Negera Edessa, Nolet Philippe, Nordberg Ana, Norden Rickard, Nowicki Jessica P., Olova Nelly, Olszewski Pawel, Onzima Robert, Pan Chih-Long, Park Charny, Park Dong Ik, Park Seyoung, Patil Chandrashekhar D., Pedro Sansoa A., Perry Samuel R., Peter Jessica, Peterson Brent M., Pezzuolo Andrea, Pozdnyakov Ilya, Qian Siyu, Qin Lei, Rafe Ali, Raote Ishier, Raza Ali, Rebl Henrike, Refai Osama, Regan Tim, Richa Tambi, Richardson Mark F., Robinson K. R., Rossoni Luca, Rouet Romain, Safaei Soroush, Schneeberger Pierre H. H., Schwotzer Daniela, Sebastian Agata, Selinski Jennifer, Seltmann Stefanie, Sha Feng, Shalev Nir, Shang Jin-Long, Singer Josef, Singh Mandeep, Smith Taylor, Solomon-Moore Emma, Song Lijuan, Soraggi Samuele, Stanley Ryan, Steckhan Nico, Strobl Frederic, Subissi Lorenzo, Supriyanto Irwan, Surve Chinmay R., Suzuki Tomo, Syme Caitlin, Sorelius Karl, Tang Young, Tantawy Marwa, Tennakoon Sumudu, Teseo Serafino, Toelzer Christine, Tomov Nikola, Tovar Miguel, Tran Linh, Tripathi Sushil, Tuladhar Anil M., Ukubuiwe Azubuike C., Ung Carolina O. L., Valgepea Kaspar, Vatanparast Hamid, Vidal Arnau, Wang Fang, Wang Qing, Watari Ricky, Webster Rebecca, Webster Ruth, Wei Junnian, Wibowo David, Wingenbach Tanja S. H., Xavier Rose M., Xiao Shumin, Xiong Peng, Xu Shicai, Xu Shilin, Yao Ruifeng, Yao Wen, Yin Qinan, Yu Yongbo, Zaitsu Masayoshi, Zeineb Zian, Zhan Xiao-Yong, Zhang Jilei, Zhang Rongqiang, Zhang Wei, Zhang Xianglilan, Zheng Shan, Zhou Bailing, Zhou Xiaoyan, Ahmad Haroon, Akinwumi Sayo A., Albery Gregory F., Alhowimel Ahmed, Ali Junaid, Alshehri Mansour, Alsuhaibani Mohammed, Anikin Andrey, Azubuike Samuel O., Bach-Mortensen Anders, Baltiansky Lior, Bartas Martin, Belachew Kiflemariam Y., Bhardwaj Vivek, Binder Karin, Bland Nicholas S., Boah Michael, Bullen Benjamin, Calabro Giovanna E., Callahan Tiffany J., Cao Bing, Chalmers Kelsey, Chang Wei, Che Zhengping, Chen Andrew T. Y., Chen Haimin, Chen Huaming, Chen Youning, Chen Zhao, Choi YoungRok, Chowdhury Mohiuddin A. K., Christensen Martin R., Cooke Robert S. C., Cottini Marzia, Covington Natalie V., Cunningham Catriona, Delarocque Julien, Devos Lucie, Dhar Aurup R., Ding Ke-Feng, Dong Kexian, Dong Zheng, Dreyer Niklas, Ekstrand Chelsea, Fardet Tanguy, Feleke Berhanu E., Feurer Thomas, Freitas Angela, Gao Tian, Asefa N. G., Giganti Francesco, Grabowski Piotr, Guerra-Mora Jose R., Guo Chengying, Guo Xinyi, Gupta Himanshu, He Shuonan, Heijne Marloes, Heinemann Stephanie, Hogrebe Alexander, Huang Zhengping, Iskander-Rizk Sophinese, Iyer Lavanya M., Jahan Yasmin, James Ameh S., Joel Emmanuel, Joffroy Bastian, Jegousse Clara, Kambondo George, Karnati Priyanka, Kaya Cihan, Ke An, Kelly Daniel, Kickert Rob, Kidibule Peter E., Kieselmann Jennifer P., Kim Hyeon J., Kitazawa Takeshi, Lamberts Aniek, Li You, Liang Huakang, Linn Sabrina N., Litfin Thomas, Liusuo Wang, Lygirou Vasiliki, Mahato Ajay K., Mai Zhi-Ming, Major Rupert W., Mali Samira, Mallis Panagiotis, Mao Wenzhi, Mao Wenzhi, Marvin-Dowle Katie, Marvin-Dowle Katie, Mason Leanda D., Merideth Ben, Merino-Plaza Maria J., Merlaen Britt, Messina Rossella, Mishra Anand K., Muhammad Junaid, Musinguzi Conrad, Nanou Afroditi, Naqash Amreen, Nguyen Joe T., Nguyen Thi T. H., Ni Duan, Nida, Notcovich Shirli, Ohst Barnabas, Ollivier Quinn R., Osses Daniel F., Peng Xiangda, Plantinga Arnoud, Pulia Michael, Rafiq Muhammad, Raman Ayush, Raucher-Chene Delphine, Rawski Rafal, Ray Asit, Razak Lubna A., Rudolf Kevin, Rusch Peter, Sadoine Margaux L., Schmidt Axel, Schurr Roey, Searles Stephen, Sharma Saurab, Sheehan Barry, Shi Chunhu, Shohayeb Belal, Sommerlad Andrew, Strehlow Jan, Sun Xianbao, Sundar Raghav, Taherzadeh Ghazaleh, Tahir Nur D. M., Tang Jun, Testa Jean, Tian Zhiqi, Tingting Qian, Verheijen Geert P., Vickstrom Casey, Wang Teng, Wang Xiaomin, Wang Zhenxing, Wei Pan, Wilson Alex, Wyart, Yassine Abdul-Amir, Yousefzadeh Abbas, Zare Asma, Zeng Zhen, Zhang Chengrong, Zhang Haowen, Zhang Linxing, Zhang Tongchuan, Zhang Weijia, Zhang Zhe, Zhou Jianyu, Zhu Dongjie, Adamo Vincenzo, Adeyemo Adebolajo A., Aggelidou Maria, Al-Owaifeer Adi M., Al-Riyami Arwa Z., Alzghari Saeed K., Andersen Vibeke, Angus Kathryn, Asaduzzaman Muhammad, Asady Hadi, Ato Dai, Bai Xiaoyong, Baines Rebecca L., Ballantyne Maghan, Ban Bo, Beck Jill, Ben-Nafa Walid, Black Emma, Blancher Antoine, Blankstein Ron, Bodagh Neil, Borges Paulo A. V., Brooks Anastasia, Brox-Ponce Josue, Brunetti Arturo, Canham Colin D., Carninci Piero, Carvajal Richard, Chang Shun C., Chao Jie, Chatterjee Pranab, Chen He, Chen Yi-Chun, Chhatriwalla Adnan K., Chikowe Ibrahim, Chuang Trees-Juen, Collevatti Rosane G., Valera-Cornejo Diego A., Cuenda Ana, Dao Myriam, Dauga Delphine, Deng Zaian, Devkota Kiran, Doan Lisa V., Elewa Yaser H. A., Fan Dongsheng, Faruk Mohammed, Feifei Shi, Ferguson Trevor S., Fleres Francesco, Foster Emma J., Foster C. Stephen, Furer Tzvi, Gao Yibo, Garcia-Rivera Enid J., Gazdar Adi, George Ronald B., Ghosh Sayantan, Gianchecchi Elena, Gleason Joshua M., Hackshaw Allan, Hall Adam, Hall Richard, Harper Paul, Hogg William E., Huang Guangqun, Hunter Kylie E., IJzerman Adriaan P., Jesus Carlos, Jian Gao, Lewis James S. Jr., Kanj Souha S., Kaur Harsheen, Kelly Shona, Kheir Fayez, Kichatova V. S., Kiyani Musa, Klein Reinhild, Kovesi Tom, Kraschnewski Jennifer L., Kumar Addanki P., Labutin Dmitry, Lazo-Langner Alejandro, Leclercq Guy, Li Maoteng, Li Qingchun, Li Tangliang, Li Yongzhe, Liao Wei-Ting, Liao Zheng-yin, Lin Jessica, Lizer J., Lobreglio Giambattista, Lowies Cher, Lu Cheng, Majeed Haroon, Martin Adam, Martinez-Sobrido Luis, Meresh Edwin, Middelveen Marianne, Mohebbi Alireza, Mota Jorge, Mozaheb Zahra, Muyaya Ley, Nandhakumar Amar, Ng Sheryl H. X., Obeidat Monther, Oh Deog-Hwan, Owais Mohammed, Pace-Asciak Pia, Panwar Ajay, Park Caroline, Patterson Chris, Penagos-Tabaree Felipe, Pianosi Paolo T., Pinzi Valentina, Pridans Clare, Psaroulaki Anna, Pujala Ravi Kumar, Pulido-Arjona Leonardo, Qi Peng-Fei, Rahman Proton, Rai Nayanjot K., Rassaf Tienush, Refardt Julie, Ricciardi Walter, Riess Olaf, Rovas Alexandros, Sacks Frank M., Saleh Sherif, Sampson Christopher, Schmutz Axel, Sepanski Robert, Sharma Neeraj, Singh Manisha, Spearman Paul, Subramaniapillai Mehala, Swali Ritu, Tan Cher M., Tellechea Juan I., Thomas Lisa-Marie, Tong Xin, Veys Ralf, Vitriol Veronica, Wang Horng-Dar, Wang Jinhui, Wang Jiucun, Waugh Jason, Webb S. A., Williams Brendan A., Workman Alan D., Xiang Tingxiu, Xie Li-Xin, Xu Jun, Xu Taosheng, Yang Chongjun, Yoon Jihoon G., Yuan Christina M., Zaritsky Arno, Zhang Yao, Zhao Haochen, Zuckerman Hannah, Lyu Ran, Pullan Wayne, Zhou Yaoqi

    DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION     page: 2019:baz085 - 2019:baz085   2019.10

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  45. Does I-131 uptake in the subhyoid portion or lymph nodes affect the outcome of low-dose ablation therapy for patients with differentiated thyroid cancer? Reviewed

    Ito S., Iwano S., Kato K., Naganawa S.

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   Vol. 46 ( SUPPL 1 ) page: S662 - S663   2019.10

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  46. Should Small Cell Carcinoma of the Cervix be Treated As Localized Small Cell Cancer or Advanced Cervical Cancer: A Retrospective Multi-Institutional Cohort Study Reviewed

    Kawamura M., Koide Y., Murai T., Ishihara S., Takase Y., Murao T., Okazaki D., Yamaguchi T., Uchiyama K., Itoh Y., Kodaira T., Shibamoto Y., Mizuno M., Kikkawa F., Naganawa S.

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   Vol. 105 ( 1 ) page: E324 - E325   2019.9

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    DOI: 10.1016/j.ijrobp.2019.06.1809

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  47. Clinical Results of T1 Glottic Cancer Treated with Radiotherapy Using 2.25 Gy per Fractions: A Multicenter Survey in Clinical Practice Reviewed

    Oie Y., Itoh Y., Kawamura M., Takase Y., Murao T., Ishihara S., Nomoto Y., Hirasawa N., Asano A., Yamakawa K., Ito J., Naganawa S.

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   Vol. 105 ( 1 ) page: E366 - E367   2019.9

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    DOI: 10.1016/j.ijrobp.2019.06.1708

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  48. Development of Three-Dimensional Printed Compensator for Improvement of Dose Distribution in Boron Neutron Capture Therapy: A Preliminary Study Reviewed

    Kamomae T., Sakurai Y., Oita M., Takata T., Niimi T., Matsumura T., Saito T., Komada T., Kato K., Itoh Y., Naganawa S.

    MEDICAL PHYSICS   Vol. 46 ( 6 ) page: E411 - E411   2019.6

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  49. Evaluation of Ra-223 therapy on bone metastases of prostate cancer by F-18-fluoride PET/CT, F-18-FDG PET/CT and bone scintigraphy/SPECT Reviewed

    Kato Katsuhiko, Odagawa Tetsuro, Fujita Naotoshi, Tsutsumi Yoshinori, Abe Shinji, Yamamoto Seiichi, Naganawa Shinji

    JOURNAL OF NUCLEAR MEDICINE   Vol. 60 ( supplement 1 ) page: 534 - 534   2019.5

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  50. Influence of implanted metals in new CT reconstruction algorithm for radiotherapy treatment planning Reviewed

    Kamomae T., Nakaya T., Kawabata F., Okudaira K., Kumagai M., Oguchi H., Itoh Y., Naganawa S.

    RADIOTHERAPY AND ONCOLOGY   Vol. 133   page: S1132 - S1132   2019.4

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    DOI: 10.1016/S0167-8140(19)32477-6

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  51. Diagnostic Radiology Service in Japan. Reviewed

    Shinji Naganawa, Yukunori Korogi

    Japanese journal of radiology   Vol. 36 ( 10 ) page: 575 - 578   2018.10

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    DOI: 10.1007/s11604-018-0770-z

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  52. Longitudinal Findings of MRI and PET in West Syndrome with Subtle Focal Cortical Dysplasia

    Sakaguchi Y., Kidokoro H., Ogawa C., Okai Y., Ito Y., Yamamoto H., Ohno A., Nakata T., Tsuji T., Nakane T., Kawai H., Kato K., Naganawa S., Natsume J.

    AMERICAN JOURNAL OF NEURORADIOLOGY   Vol. 39 ( 10 ) page: 1932 - 1937   2018.10

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    DOI: 10.3174/ajnr.A5772

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  53. PREDICTION OF INTRACRANIAL ARTERIAL STENOSIS PROGRESSION IN PATIENTS WITH MOYAMOYA VASCULOPATHY: CONTRAST-ENHANCED HIGH-RESOLUTION MAGNETIC RESONANCE VESSELWALL IMAGING

    Muraoka S., Araki Y., Taoka T., Kawai H., Okamoto S., Uda K., Ota S., Naganawa S., Wakabayashi T.

    INTERNATIONAL JOURNAL OF STROKE   Vol. 13   page: 32 - 32   2018.10

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  54. Prediction of recurrence using volume-based metabolic index obtained by preoperative FDG-PET for non-small-cell lung cancer

    Ito S., Iwano S., Kato K., Naganawa S.

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   Vol. 45   page: S506 - S506   2018.10

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  55. Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy. Reviewed International journal

    Kazuhiro Hara, Hirohisa Watanabe, Epifanio Bagarinao, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Takashi Tsuboi, Mizuki Ito, Naoki Atsuta, Hisayoshi Niwa, Toshiaki Taoka, Satoshi Maesawa, Shinji Naganawa, Masahisa Katsuno, Gen Sobue

    Journal of neurology   Vol. 265 ( 9 ) page: 2079 - 2087   2018.9

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    OBJECTIVE: We examined the anatomical involvement related to cognitive impairment in patients with multiple system atrophy (MSA). METHODS: We examined 30 patients with probable MSA and 15 healthy controls. All MSA patients were assessed by the Unified MSA-Rating scale and Addenbrooke's Cognitive Examination-Revised (ACE-R). We classified 15 MSA patients with ACE-R scores > 88 as having normal cognition (MSA-NC) and 15 with scores ≤ 88 as having cognitive impairment (MSA-CI). All subjects underwent 3 T MRI scanning and were investigated using voxel-based morphometry and diffusion tensor imaging. RESULTS: Both the MSA-NC and MSA-CI patients exhibited cerebellar but not cerebral atrophy in voxel-based morphometry compared to controls. In contrast, tract-based spatial statistics revealed widespread and significantly decreased fractional anisotropy (FA) values, as well as increased mean diffusivity, radial diffusivity, and axial diffusivity in both the cerebrum and cerebellum in MSA-CI patients compared to controls. MSA-NC patients also exhibited similar involvement of the cerebellum but less extensive involvement of the cerebrum compared with the MSA-CI patients. In particular, FA values in MSA-CI patients were significantly decreased in the anterior part of the left corpus callosum compared with those in MSA-NC patients. The mean FA values in the left anterior part of the corpus callosum were significantly correlated with total ACE-R scores and subscores (memory, fluency, and language) in MSA patients. CONCLUSIONS: Decreased FA values in the anterior corpus callosum showed a significant correlation with cognitive impairment in MSA.

    DOI: 10.1007/s00415-018-8923-7

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  56. Prediction of Intracranial Arterial Stenosis Progression in Patients with Moyamoya Vasculopathy: Contrast-Enhanced High-Resolution Magnetic Resonance Vessel Wall Imaging. Reviewed International journal

    Shinsuke Muraoka, Yoshio Araki, Toshiaki Taoka, Hisashi Kawai, Sho Okamoto, Kenji Uda, Shinji Ota, Shinji Naganawa, Toshihiko Wakabayashi

    World neurosurgery   Vol. 116   page: e1114 - e1121   2018.8

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    OBJECTIVE: Moyamoya vasculopathy (MMV) is characterized by progressive stenosis of the intracranial arteries. MMV currently has no curative treatments, and cerebral ischemia and hemorrhage are the major outcomes. Evaluation of the stroke risk of each patient resulting from the progression of intracranial arterial stenosis is clinically important. METHODS: We prospectively reviewed patients with intracranial arterial stenosis and already diagnosed MMV. High-resolution magnetic resonance imaging using contrast agent is the novel vessel wall imaging (VWI) technique for directly evaluating vascular walls and intracranial artery disease. All patients underwent high-resolution vessel wall imaging and magnetic resonance angiography at the time of registration, and they underwent follow-up magnetic resonance angiography. The Fisher exact test was used to assess associations between the degrees of wall enhancement and between stable and progressive intracranial arterial stenosis. RESULTS: A total of 24 patients (17 female; mean age, 36.1 ± 16.8 years; range 3-67 years) with MMV were consecutively recruited to this study. Progression of stenosis was shown in 6 lesions (66.6%) on strong enhancement, 2 lesions (12.5%) on mild enhancement, and 1 lesion (4.3%) on lack of enhancement. Arterial vessel wall enhancement in MMV patients correlated closely with progression of intracranial arterial stenosis (P = 0.002). CONCLUSIONS: Arterial vessel wall enhancement in MMV patients was closely related to progression of intracranial arterial stenosis. Strong enhancement of the intracranial vessel wall was associated with intracranial arterial stenosis progression, and lack of enhancement correlated with the stability of intracranial arterial stenosis.

    DOI: 10.1016/j.wneu.2018.05.181

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  57. Study Protocol: Prospective Study of Concurrent Chemoradiotherapy with S-1 and Hypofractionated Radiotherapy for Outpatients with Early Glottic Squamous Cell Carcinomas Reviewed International journal

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Seiji Kubota, Mariko Kawamura, Rie Nakahara, Yumi Oie, Yuka Kozai, Yuuki Takase, Hidenori Tsuzuki, Naoki Nishio, Mariko Hiramatsu, Yasushi Fujimoto, Takefumi Mizutani, Akihiro Hirakawa, Shinji Naganawa

    Asian Pacific journal of cancer prevention : APJCP   Vol. 19 ( 5 ) page: 1195 - 1199   2018.5

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    Background: The recommended treatment strategies for early glottic carcinoma with intent of larynx preservation are
    primarily radiotherapy. However, the outcomes of radiotherapy for bulky T1 or T2 glottic carcinoma are unsatisfactory.
    We designed a protocol consisting of concurrent chemoradiotherapy using S-1 as the radiosensitizer. We have performed
    this protocol in patients with favorable T2 lesions and demonstrated its efficacy and safety. In contrast, we have
    treated non-bulky T1 glottic carcinomas with 2.25 Gy per fraction, for a total of 25-28 fractions, starting in 2011 to
    improve efficacy and shorten the treatment period. Since this treatment strategy was implemented for T1 disease, no
    local failure has occurred to date, and it appears to be almost as safe as radiotherapy using 2.0 Gy per fraction. With
    the aim of improving the local control rate and shortening the treatment period primarily for favorable T2 disease, we
    changed the dose of radiation in our protocol from 2.0 Gy to 2.25 Gy per fraction, for a total of 25 fractions (from 30
    fractions). The present study aims to evaluate the efficacy and safety of this new protocol. Methods: This study will
    be conducted as a clinical, prospective, single-armed, non-randomized trial. Patients are to receive S-1 (55.3 mg /m2
    /day, once daily) and radiotherapy (2.25 Gy per fraction, for a total of 25 fractions). S-1 and radiotherapy are started
    on the same day that radiotherapy is performed, 3-6 hours after oral administration of S-1. The primary study aim is
    the 3-year local control rate. The secondary study aims are overall survival, voice-preservation survival, disease-free
    survival, complete response rate, completion rate, and toxicity. Result and conclusion: This is the first single-center,
    non-randomized, prospective study of concurrent chemoradiotherapy with S-1 and hypofractionated radiotherapy to
    be conducted. The trial will evaluate the efficacy and safety of our protocol.

    DOI: 10.22034/APJCP.2018.19.5.1195

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  58. Evaluation of the tumoricidal and pain relief effects of Sr-89 on bone metastases of cancer by F-18-fluoride PET/CT, F-18-FDG PET/CT, bone scintigraphy/SPECT, and follow-up

    Kato Katsuhiko, Odagawa Tetsuro, Fujita Naotoshi, Tsutsumi Yoshinori, Matsuzawa Shinichiro, Mukumoto Ryuto, Hasegawa Chinatsu, Abe Shinji, Naganawa Shinji

    JOURNAL OF NUCLEAR MEDICINE   Vol. 59   page: .   2018.5

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  59. Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer. Reviewed International journal

    Suguru Yamada, Tsutomu Fujii, Yukihiro Yokoyama, Hiroki Kawashima, Osamu Maeda, Kojiro Suzuki, Tohru Okada, Eizaburo Ono, Junpei Yamaguchi, Nao Takano, Hideki Takami, Masamichi Hayashi, Yukiko Niwa, Yoshiki Hirooka, Yoshiyuki Ito, Shinji Naganawa, Yuichi Ando, Masato Nagino, Hidemi Goto, Yasuhiro Kodera

    Cancer chemotherapy and pharmacology   Vol. 81 ( 5 ) page: 815 - 821   2018.5

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    PURPOSE: For unresectable locally advanced (UR-LA) pancreatic cancer, chemoradiotherapy has been recommended by the NCCN guidelines. We designed a chemoradiotherapy protocol using nab-paclitaxel combined with gemcitabine (GnP) for patients with UR-LA pancreatic cancer. The purpose of this phase I study was to determine a recommended dose (RD) for this novel regimen. METHODS: Patients with UR-LA pancreatic cancer were eligible. The frequency of dose-limiting toxicities (DLTs) was evaluated, and the RD was determined. Patients were classified according to the designated dose levels of chemoradiotherapy using the GnP regimen. After additional 6 cycles of the GnP regimen were administered, surgery was considered if the patients had stable disease and tumor marker levels had normalized. RESULTS: DLT (grade 4 thrombocytopenia) was observed only in 1 of 12 patients, and the RD was set at level 3. Grade 3-4 leukopenia was observed in 9 (75.0%) patients, and neutropenia in 7 (58.3%). The response rate was 41.7%, and the disease control rate was 100%. Conversion surgery was performed in 6 (50%) patients, and curative resection (R0) was performed in all 6 patients (100%). Stratification according to the Evans classification system demonstrated one patient with grade 1b, one with grade 2, two with grade 3, and two with grade 4 disease. CONCLUSION: The RD for weekly administration was 800 mg/m2 for gemcitabine and 100 mg/m2 for nab-paclitaxel with a 50.4 Gy radiation. The GnP regimen at this dosage was promising with 6 of 12 patients proceeding to conversion surgery, and should be evaluated further in a phase II trial.

    DOI: 10.1007/s00280-018-3554-3

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  60. Efficacy of percutaneous transhepatic portal vein embolization using gelatin sponge particles and metal coils. International journal

    Tomohiro Komada, Kojiro Suzuki, Takashi Mizuno, Tomoki Ebata, Masaya Matsushima, Shinji Naganawa, Masato Nagino

    Acta radiologica open   Vol. 7 ( 4 ) page: 2058460118769687 - 2058460118769687   2018.4

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    Background: Percutaneous transhepatic portal vein embolization (PTPE) can increase the future liver remnant (FLR) volume before extended liver resection; however, there is no current consensus regarding the best embolic material for PTPE. Purpose: To evaluate the efficacy of PTPE using gelatin sponge particles and coils. Material and Methods: The medical records of 136 patients who underwent PTPE using gelatin sponge particles and metal coils were retrospectively reviewed. We evaluated the procedural details, liver volume on CT, and clinical status before and after PTPE. Results: The mean FLR volume increased significantly from 390 ± 147 cm3 to 508 ± 141 cm3 (P < 0.001). A mean of 22.1 ± 9.4 days after PTPE, the mean increase in the ratio of FLR volume to total liver volume was 9.4 ± 6.5%. Complications related to PTPE occurred in five patients, including arterial damage (n = 4) and biloma (n = 1). The white blood cell count and C-reactive protein level increased significantly and then returned to baseline within seven days. Aspartate aminotransferase and alanine aminotransferase showed no significant changes. Fever (defined by the Common Terminology Criteria for Adverse Events v4.0) was reported in 74 patients (54%), but it was generally mild (Grade 1/2; n = 72). None of the patients experienced severe complications that required cancellation of surgery. Conclusion: PTPE with gelatin sponge particles and coils may impose low physical stress on patients and is a safe method of inducing a significant increase of FLR.

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  61. Detecting sub-second changes in brain activation patterns during interictal epileptic spike using simultaneous EEG-fMRI. Reviewed International journal

    Epifanio Bagarinao, Satoshi Maesawa, Yuji Ito, Naotaka Usui, Jun Natsume, Hirohisa Watanabe, Minoru Hoshiyama, Toshihiko Wakabayashi, Gen Sobue, Shinji Naganawa, Haruo Isoda

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology   Vol. 129 ( 2 ) page: 377 - 389   2018.2

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    OBJECTIVE: Epileptic spikes are associated with rapidly changing brain activation involving the epileptic foci and other brain regions in the "epileptic network". We aim to resolve these activation changes using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings. METHODS: Simultaneous EEG-fMRI recordings from 9 patients with epilepsy were used in the analysis. Our method employed the whole scalp EEG data to generate regressors for the analysis of fMRI data using the general linear model. RESULTS: We were able to resolve, with milliseconds temporal resolution, changes in activation patterns involving suspected epileptic foci and other brain regions in the epileptic network during spike and slow wave. Using summary maps (called SSWAS maps) which show the activation frequency of voxels, we found that suspected epileptic foci tend to be significantly active during this interval. SSWAS maps also enabled the detection of the epileptic foci in 4 of 5 patients where the conventional event-timing-based analysis failed to identify. CONCLUSION: These findings demonstrated the efficacy of the method and the potential application of SSWAS maps to identify epileptic foci. SIGNIFICANCE: The method could help resolve activation changes during epileptic spike and could provide insights into the underlying pathophysiology of these changes.

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  62. Effects of Gradient Coil Noise and Gradient Coil Replacement on the Reproducibility of Resting State Networks. Reviewed International journal

    Epifanio Bagarinao, Erina Tsuzuki, Yukina Yoshida, Yohei Ozawa, Maki Kuzuya, Takashi Otani, Shuji Koyama, Haruo Isoda, Hirohisa Watanabe, Satoshi Maesawa, Shinji Naganawa, Gen Sobue

    Frontiers in human neuroscience   Vol. 12   page: 148 - 148   2018

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    The stability of the MRI scanner throughout a given study is critical in minimizing hardware-induced variability in the acquired imaging data set. However, MRI scanners do malfunction at times, which could generate image artifacts and would require the replacement of a major component such as its gradient coil. In this article, we examined the effect of low intensity, randomly occurring hardware-related noise due to a faulty gradient coil on brain morphometric measures derived from T1-weighted images and resting state networks (RSNs) constructed from resting state functional MRI. We also introduced a method to detect and minimize the effect of the noise associated with a faulty gradient coil. Finally, we assessed the reproducibility of these morphometric measures and RSNs before and after gradient coil replacement. Our results showed that gradient coil noise, even at relatively low intensities, could introduce a large number of voxels exhibiting spurious significant connectivity changes in several RSNs. However, censoring the affected volumes during the analysis could minimize, if not completely eliminate, these spurious connectivity changes and could lead to reproducible RSNs even after gradient coil replacement.

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  63. Three-dimensional printer-generated patient-specific phantom for artificial in vivo dosimetry in radiotherapy quality assurance. Reviewed International journal

    Takeshi Kamomae, Hidetoshi Shimizu, Takayoshi Nakaya, Kuniyasu Okudaira, Takahiro Aoyama, Hiroshi Oguchi, Masataka Komori, Mariko Kawamura, Kazuhiro Ohtakara, Hajime Monzen, Yoshiyuki Itoh, Shinji Naganawa

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)   Vol. 44   page: 205 - 211   2017.12

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    Pretreatment intensity-modulated radiotherapy quality assurance is performed using simple rectangular or cylindrical phantoms; thus, the dosimetric errors caused by complex patient-specific anatomy are absent in the evaluation objects. In this study, we construct a system for generating patient-specific three-dimensional (3D)-printed phantoms for radiotherapy dosimetry. An anthropomorphic head phantom containing the bone and hollow of the paranasal sinus is scanned by computed tomography (CT). Based on surface rendering data, a patient-specific phantom is formed using a fused-deposition-modeling-based 3D printer, with a polylactic acid filament as the printing material. Radiophotoluminescence glass dosimeters can be inserted in the 3D-printed phantom. The phantom shape, CT value, and absorbed doses are compared between the actual and 3D-printed phantoms. The shape difference between the actual and printed phantoms is less than 1 mm except in the bottom surface region. The average CT value of the infill region in the 3D-printed phantom is -6 ± 18 Hounsfield units (HU) and that of the vertical shell region is 126 ± 18 HU. When the same plans were irradiated, the dose differences were generally less than 2%. These results demonstrate the feasibility of the 3D-printed phantom for artificial in vivo dosimetry in radiotherapy quality assurance.

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  64. Clinical outcomes of 125I brachytherapy with and without external-beam radiation therapy for localized prostate cancer: results from 300 patients at a single institution in Japan. Reviewed International journal

    Sayo Maki, Yoshiyuki Itoh, Seiji Kubota, Tohru Okada, Rie Nakahara, Junji Ito, Mariko Kawamura, Shinji Naganawa, Yasushi Yoshino, Takashi Fujita, Masashi Kato, Momokazu Gotoh, Mitsuru Ikeda

    Journal of radiation research   Vol. 58 ( 6 ) page: 870 - 880   2017.11

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    The aim of this study was to determine the outcomes and adverse events for 300 men with prostate cancer treated with 125iodine (125I) brachytherapy with and without external-beam radiation therapy (EBRT) at a single institution in Japan. Between February 2005 and November 2011, 300 consecutive patients with clinically localized prostate cancer were treated with 125I brachytherapy at the Nagoya University Hospital. A total of 271 men were treated with implants with doses of 145 Gy, and 29 men were treated with implants with doses of 110 Gy combined with EBRT (40-50 Gy/20-25 fractions). The median patient age was 69 years (range, 53-83 years). The median follow-up period was 53 months (range, 5-99 months). According to the National Comprehensive Cancer Network risk classification, 132 men (44%) had low-risk, 147 men (29%) had intermediate-risk and 21 men (7%) had high-risk disease. The 5-year overall survival rate, biochemical relapse-free survival rate, and disease-specific survival rates were 93.5%, 97.3% and 98.5%, respectively. Two men (0.6%) died of prostate cancer and 10 men (3.3%) died of other causes. Seventeen men (5.6%) experienced Grade 2 rectal bleeding in all: 12 (41.4%) of 29 in brachytherapy with EBRT, and 5 (1.8%) of 271 in brachytherapy alone. The rates of Grade 2 and 3 genitourinary toxicity were 1.0% and 1.7%, respectively. Excellent local control was achieved at our hospital for localized prostate cancer with 125I brachytherapy with and without EBRT. Gastrointestinal and genitourinary toxicities were acceptable.

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  65. Comparison of I-123-IMP SPECT, F-18-FDG PET/CT, and F-18-FDOPA PET/CT in Detection of Choroidal Malignant Melanoma

    Kato K., Odagawa T., Tsutsumi T., Honda M., Kunimoto K., Mukumoto R., Matsuzawa S., Abe S., Naganawa S.

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   Vol. 44   page: S745 - S745   2017.10

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  66. Development of the breast immobilization system in prone setup: The effect of bra in prone position to improve the breast setup error. Reviewed International journal

    Mariko Kawamura, Yoshikazu Maeda, Kazutaka Yamamoto, Shigeyuki Takamatsu, Yoshitaka Sato, Hiroki Minami, Yusuke Saga, Kyo Kume, Yuji Tameshige, Makoto Sasaki, Hiroyasu Tamamura, Kouji Ohta, Yoshiyuki Itoh, Shinji Naganawa

    Journal of applied clinical medical physics   Vol. 18 ( 4 ) page: 155 - 160   2017.7

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    PURPOSE/OBJECTIVE(S): Accurate and reproducible positioning of the breast is difficult due to its deformability and softness; thus, targeting a breast tumor or tumor bed with fractionated radiotherapy using external beam radiation is difficult. The aim of this study was to develop a novel bra to aid in breast immobilization in the prone position. MATERIALS & METHODS: To assess the accuracy of prone position fixation of breast tumors, 33 breast cancer patients with 34 lesions were recruited. The bra used in this verification was customized from a commercially available bra. Duplicate MRI were acquired in the prone position, alternating with and without the bra, and for each series, patients were asked to step off the MRI table and re-set up in the prone position. Patients were also asked to remove and re-fit the bra for the second MRI. Each pair of images were superimposed to match the shape of the skin surface, and the maximum difference in tumor geometric center in three axes was measured. The required set up margin was calculated as: required margin = mean difference in geometric center + 2.5 standard deviation. The volumetric overlap of the tumor, as well as contouring uncertainties, was evaluated using contour analysis software. RESULTS: The median breast size was 498 cc. The required margins for the lateral, vertical, and longitudinal directions were estimated to be 4.1, 4.1, and 5.0 mm, respectively, with the bra, and 5.1, 6.9, and 6.7 mm, respectively, without the bra. These margins covered the dislocation of more than 33 lesions in total. With the bra, 33 lesions had achieved an objective overlap of 95% and 99% with 2 and 4 mm margins, respectively, whereas 4 and 8 mm, respectively, were needed without the bra. CONCLUSION: The use of an immobilizing bra reduced the setup margin for prone position fixation of breast tumors.

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  67. Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue Reviewed International journal

    Gregor Jost, Thomas Frenzel, Jessica Lohrke, Diana Constanze Lenhard, Shinji Naganawa, Hubertus Pietsch

    EUROPEAN RADIOLOGY   Vol. 27 ( 7 ) page: 2877 - 2885   2017.7

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    Signal hyperintensity on unenhanced MRI in certain brain regions has been reported after multiple administrations of some, but not all, gadolinium-based contrast agents (GBCAs). One potential initial pathway of GBCA entry into the brain, infiltration from blood into the cerebrospinal fluid (CSF), was systematically evaluated in this preclinical study.
    GBCA infiltration and distribution in the CSF were investigated in healthy rats using repeated fluid-attenuated MRI up to 4 h after high-dose (1.8 mmol/kg) administration of six marketed and one experimental GBCA. Additionally, gadolinium measurements in CSF, blood and brain tissue samples (after 24 h) were performed using inductively coupled plasma mass spectrometry.
    Enhanced MRI signals in the CSF spaces with similar distribution kinetics were observed for all GBCAs. No substantial differences in the gadolinium concentrations among the marketed GBCAs were found in the CSF, blood or brain tissue. After 4.5 h, the concentration in the CSF was clearly higher than in blood but was almost completely cleared and lower than the brain tissue concentration after 24 h.
    In contrast to the brain signal hyperintensities, no differences in penetration and distribution into the CSF of healthy rats exist among the marketed GBCAs.
    aEuro cent Gadolinium-based contrast agents can cross the blood-CSF barrier.
    aEuro cent Fluid-attenuated MRI shows GBCA distribution with CSF flow.
    aEuro cent GBCA structure and physicochemical properties do not impact CSF penetration and distribution.
    aEuro cent GBCA clearance from CSF was almost complete within 24 h in rats.
    aEuro cent CSF is a potential pathway of GBCA entry into the brain.

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  68. Clinical outcome of definitive radiation therapy for superficial esophageal cancer. Reviewed International journal

    Yutaro Koide, Takeshi Kodaira, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Makoto Itoh, Tetsuya Abe, Kei Muro, Masahiro Tajika, Yasumasa Niwa, Yoshiyuki Itoh, Shinji Naganawa

    Japanese journal of clinical oncology   Vol. 47 ( 5 ) page: 393 - 400   2017.5

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    Objective: To analyze the clinical outcome of concurrent chemoradiotherapy in superficial esophageal cancer patients. Methods: We retrospectively analyzed data for 123 patients with superficial esophageal cancer who received external beam radiotherapy without intracavitary brachytherapy plus systemic chemotherapy during 1998-2015. Elective nodal irradiation was not performed. The dosage to planning treatment volume was 60 Gy in 30 fractions. The main outcome measure was overall survival. Results: Patient characteristics were as follows: median age, 66 (41-83) years; male/female ratio, 106/17; squamous cell carcinoma/other, 122/1; cT1a/cT1b, 27/96; cervical esophagus/upper thoracic esophagus/middle thoracic esophagus/lower thoracic esophagus, 7/9/66/41 and concurrent chemoradiotherapy/radiotherapy alone, 100/23. Cisplatin and 5-fluorouracil were the most commonly used agents (85%). At the last follow-up (median 60.5 months), 91 (74%) patients were alive. Complete response was achieved in 116 (94.4%) patients. The 5-year overall survival, progression-free survival and local control rates were 77.0, 46.9 and 62.7%, respectively, similar to that in the elderly patients (P = 0.878, 0.754 and 0.648, respectively). There were 55 failures: 42 local, 10 regional and 3 distant failures. Nine local and seven regional failures developed out-of-field. Thirty-eight local failures (90%) were successfully salvaged, of which 30 (71%) were salvaged via endoscopic removal; only 2 regional failures (20%) were salvaged. Fifteen G3 acute toxicities occurred. One pneumonitis (G3), one pneumothorax (G3) and two pericardial effusion (G2) were the late toxicities observed. There were no G4 toxicities or treatment-related deaths. Conclusions: Concurrent chemoradiotherapy without intracavitary brachytherapy was effective and safe for superficial esophageal cancer, even in elderly patients.

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  69. Lack of Contrast Enhancement in a Giant Perivascular Space of the Basal Ganglion on Delayed FLAIR Images: Implications for the Glymphatic System. Reviewed

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 16 ( 2 ) page: 89 - 90   2017.4

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  70. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. Reviewed

    Toshiaki Taoka, Yoshitaka Masutani, Hisashi Kawai, Toshiki Nakane, Kiwamu Matsuoka, Fumihiko Yasuno, Toshifumi Kishimoto, Shinji Naganawa

    Japanese journal of radiology   Vol. 35 ( 4 ) page: 172 - 178   2017.4

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    PURPOSE: The activity of the glymphatic system is impaired in animal models of Alzheimer's disease (AD). We evaluated the activity of the human glymphatic system in cases of AD with a diffusion-based technique called diffusion tensor image analysis along the perivascular space (DTI-ALPS). MATERIALS AND METHODS: Diffusion tensor images were acquired to calculate diffusivities in the x, y, and z axes of the plane of the lateral ventricle body in 31 patients. We evaluated the diffusivity along the perivascular spaces as well as projection fibers and association fibers separately, to acquire an index for diffusivity along the perivascular space (ALPS-index) and correlated them with the mini mental state examinations (MMSE) score. RESULTS: We found a significant negative correlation between diffusivity along the projection fibers and association fibers. We also observed a significant positive correlation between diffusivity along perivascular spaces shown as ALPS-index and the MMSE score, indicating lower water diffusivity along the perivascular space in relation to AD severity. CONCLUSION: Activity of the glymphatic system may be evaluated with diffusion images. Lower diffusivity along the perivascular space on DTI-APLS seems to reflect impairment of the glymphatic system. This method may be useful for evaluating the activity of the glymphatic system.

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  71. Magnetic resonance imaging evaluation of endolymphatic hydrops andpost-operative findings in cases with otosclerosis Reviewed

    Michihiko Sone, Tadao Yoshida, Satofumi Sugimoto, Kyoko Morimoto, Yuriko Okazaki, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima

    ACTA OTO-LARYNGOLOGICA   Vol. 137 ( 3 ) page: 242 - 245   2017.3

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    Conclusions: The presence of endolymphatic hydrops (EH) in the vestibule on magnetic resonance imaging (MRI) might be a high-risk factor for complications in cases that are candidates for stapes surgery.
    Objective: Pre-operative detection of EH could be valuable in cases that are candidates for stapes surgery to prevent unpredictable complications following surgery. Pre-operative MRI findings and post-operative findings following stapes surgery were compared to evaluate the efficacy of such MRI evaluation for the management of cases with otosclerosis.
    Subjects and methods: Sixteen cases who underwent pre-operative evaluation by 3T MRI performed 4h after intravenous injection of gadolinium and stapes surgery for otosclerosis were recruited. Imaging data concerning the degree of EH in the vestibule and cochlea were compared with post-operative clinical findings for all cases.
    Results: Mild EH in the cochlea or the vestibule was observed in eight ears and one ear, respectively, whereas one ear showed significant EH both in the cochlea and the vestibule. The post-operative course was uneventful in 12 of 14 cases with no EH in the vestibule, and the other two cases had a short period of dizziness, but two cases with EH in the vestibule had a long period of dizziness.

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  72. Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer. Reviewed

    Rise Miyauchi, Yoshiyuki Itoh, Mariko Kawamura, Akihiro Hirakawa, Kiyosumi Shibata, Hiroaki Kajiyama, Rie Nakahara, Seiji Kubota, Junji Ito, Tohru Okada, Fumitaka Kikkawa, Shinji Naganawa

    Nagoya journal of medical science   Vol. 79 ( 2 ) page: 211 - 220   2017.2

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    The purpose of this retrospective study was to analyze data in patients with stage IB-IIB uterine cervical cancer who were treated with concurrent chemoradiotherapy (CCRT) with high dose cisplatin and fluorouracil as postoperative adjuvant therapy. Between February 2003 and November 2011, 76 patients with FIGO stage IB-IIB cervical cancer were analyzed. Seventy patients were treated with postoperative CCRT and 6 patients were treated with radiation therapy alone. Data related to overall survival (OS), disease-free survival (DFS), toxicity, and failure pattern were analyzed. The median patient age was 45 years (range, 20-80 years). The median follow-up duration was 63 months (range, 10-125 months). Fifty-eight patients (76.3%) had a squamous cell histologic type, 55 patients (72.4%) had lymphovascular invasion, 31 patients (40.8%) had parametrial invasion, and 28 patients (36.8%) had lymph node metastases. Five-year OS and DFS were 96% and 92%, respectively. Five-year DFS in stage IB1 patients was significantly higher than in stage IB2-IIB patients (p = 0.022). Nineteen patients (25%) had grade 3 or 4 neutropenia, 13 patients (17.1%) had grade 3 anemia, and 2 patients (2.6%) had grade 3 thrombocytopenia, but none of these patients died from the disease. Three patients experienced chronic toxicity: one had bladder perforation, one had hydronephrosis, and one experienced ileus. CCRT as postoperative adjuvant therapy resulted in good survival and outcome without severe toxicity.

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  73. Structure of the Medullary Veins of the Cerebral Hemisphere and Related Disorders Reviewed

    Toshiaki Taoka, Akio Fukusumi, Toshiteru Miyasaka, Hisashi Kawai, Toshiki Nakane, Kimihiko Kichikawa, Shinji Naganawa

    RADIOGRAPHICS   Vol. 37 ( 1 ) page: 281 - 297   2017.1

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    Deep medullary veins drain into subependymal veins with four convergence zones and show parallel distribution patterns adjacent to the body or inferior horn and a radial pattern in the frontal horn or trigon of the lateral ventricle. As white matter imaging develops such as diffusion tensor imaging or susceptibility-weighted imaging, requirements for understanding of white matter structures are increasing, not only for understanding of neuronal tracts but also for that of other structures including the fine anatomy of white matter vessels. Some disorders are related to deep medullary veins and show characteristic distributions of the lesions indicating the relationship to the medullary veins. When lesions show a parallel or radial distribution pattern in the certebral deep white matter, disorders related to deep medullary veins should be considered for differential diagnosis. In this review, we discuss disorders related to deep medullary veins, including (a) anomalies of the medullary veins, (b) hemorrhagic disorders related to the medullary veins (diffuse vascular injury due to high-energy trauma, deep medullary vein engorgement/thrombosis in neonates), (c) inflammatory changes that spread along the medullary veins, (d) neoplasms within the medullary veins, and (e) metabolic changes that lead to altered visualization of medullary veins. Understanding the anatomic structure of medullary veins in the cerebral hemisphere and becoming familiar with disorders in which the medullary veins play a major role in disease development may be helpful in the interpretation of brain images. (C) RSNA, 2017

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  74. Endolymphatic hydrops in patients with unilateral and bilateral Meniere's disease Reviewed

    Kyoko Morimoto, Tadao Yoshida, Saiko Sugiura, Masahiro Kato, Ken Kato, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

    ACTA OTO-LARYNGOLOGICA   Vol. 137 ( 1 ) page: 23 - 28   2017.1

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    Conclusion: All definite Meniere's disease (MD) had endolymphatic hydrops (EH) at least in the cochlea or the vestibule. Symptoms of MD may appear after formation of EH. It is assumed that the probability of immediate progression to bilateral MD from unilateral MD is very low in patients without EH on the non-affected side.
    Objective: To evaluate the EH on both sides in patients with unilateral and bilateral MD, and to investigate factors with progression to bilateral MD including the degree of EH, hearing level, and the duration of MD.
    Patients and methods: The study included 29 patients with unilateral definite MD and 12 patients with bilateral definite MD. The endolymphatic space size was visualized by using 3-Tesla magnetic resonance imaging.
    Results: All patients with unilateral and bilateral MD had significant or mild EH at least in the cochlea or the vestibule on the affected side. On the non-affected side, EH was not observed at all in eight patients, but asymptomatic EH was observed in the cochlea in 14 patients and in the vestibule in 16 patients. There was no relationship between the EH on the non-affected side and the duration of MD.

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  75. Emerging neuroradiological topics in journals from related societies Reviewed

    Yukunori Korogi, Shinji Naganawa

    JAPANESE JOURNAL OF RADIOLOGY   Vol. 35 ( 1 ) page: 1 - 2   2017.1

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  76. Thoracic Temporal Subtraction Three Dimensional Computed Tomography (3D-CT): Screening for Vertebral Metastases of Primary Lung Cancers. Reviewed International journal

    Shingo Iwano, Rintaro Ito, Hiroyasu Umakoshi, Takatoshi Karino, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    PloS one   Vol. 12 ( 1 ) page: e0170309   2017

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    PURPOSE: We developed an original, computer-aided diagnosis (CAD) software that subtracts the initial thoracic vertebral three-dimensional computed tomography (3D-CT) image from the follow-up 3D-CT image. The aim of this study was to investigate the efficacy of this CAD software during screening for vertebral metastases on follow-up CT images of primary lung cancer patients. MATERIALS AND METHODS: The interpretation experiment included 30 sets of follow-up CT scans in primary lung cancer patients and was performed by two readers (readers A and B), who each had 2.5 years' experience reading CT images. In 395 vertebrae from C6 to L3, 46 vertebral metastases were identified as follows: osteolytic metastases (n = 17), osteoblastic metastases (n = 14), combined osteolytic and osteoblastic metastases (n = 6), and pathological fractures (n = 9). Thirty-six lesions were in the anterior component (vertebral body), and 10 lesions were in the posterior component (vertebral arch, transverse process, and spinous process). The area under the curve (AUC) by receiver operating characteristic (ROC) curve analysis and the sensitivity and specificity for detecting vertebral metastases were compared with and without CAD for each observer. RESULTS: Reader A detected 47 abnormalities on CT images without CAD, and 33 of them were true-positive metastatic lesions. Using CAD, reader A detected 57 abnormalities, and 38 were true positives. The sensitivity increased from 0.717 to 0.826, and on ROC curve analysis, AUC with CAD was significantly higher than that without CAD (0.849 vs. 0.902, p = 0.021). Reader B detected 40 abnormalities on CT images without CAD, and 36 of them were true-positive metastatic lesions. Using CAD, reader B detected 44 abnormalities, and 39 were true positives. The sensitivity increased from 0.783 to 0.848, and AUC with CAD was nonsignificantly higher than that without CAD (0.889 vs. 0.910, p = 0.341). Both readers detected more osteolytic and osteoblastic metastases with CAD than without CAD. CONCLUSION: Our temporal 3D-CT subtraction CAD software easily detected vertebral metastases on the follow-up CT images of lung cancer patients regardless of the osteolytic or osteoblastic nature of the lesions.

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  77. Applications of artificial intelligence in interventional oncology: An up-to-date review of the literature Reviewed

    Yusuke Matsui, Daiju Ueda, Shohei Fujita, Yasutaka Fushimi, Takahiro Tsuboyama, Koji Kamagata, Rintaro Ito, Masahiro Yanagawa, Akira Yamada, Mariko Kawamura, Takeshi Nakaura, Noriyuki Fujima, Taiki Nozaki, Fuminari Tatsugami, Tomoyuki Fujioka, Kenji Hirata, Shinji Naganawa

    Japanese Journal of Radiology     2024.10

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    Abstract

    Interventional oncology provides image-guided therapies, including transarterial tumor embolization and percutaneous tumor ablation, for malignant tumors in a minimally invasive manner. As in other medical fields, the application of artificial intelligence (AI) in interventional oncology has garnered significant attention. This narrative review describes the current state of AI applications in interventional oncology based on recent literature. A literature search revealed a rapid increase in the number of studies relevant to this topic recently. Investigators have attempted to use AI for various tasks, including automatic segmentation of organs, tumors, and treatment areas; treatment simulation; improvement of intraprocedural image quality; prediction of treatment outcomes; and detection of post-treatment recurrence. Among these, the AI-based prediction of treatment outcomes has been the most studied. Various deep and conventional machine learning algorithms have been proposed for these tasks. Radiomics has often been incorporated into prediction and detection models. Current literature suggests that AI is potentially useful in various aspects of interventional oncology, from treatment planning to post-treatment follow-up. However, most AI-based methods discussed in this review are still at the research stage, and few have been implemented in clinical practice. To achieve widespread adoption of AI technologies in interventional oncology procedures, further research on their reliability and clinical utility is necessary. Nevertheless, considering the rapid research progress in this field, various AI technologies will be integrated into interventional oncology practices in the near future.

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    Other Link: https://link.springer.com/article/10.1007/s11604-024-01668-3/fulltext.html

  78. Generative AI and large language models in nuclear medicine: current status and future prospects.

    Kenji Hirata, Yusuke Matsui, Akira Yamada, Tomoyuki Fujioka, Masahiro Yanagawa, Takeshi Nakaura, Rintaro Ito, Daiju Ueda, Shohei Fujita, Fuminari Tatsugami, Yasutaka Fushimi, Takahiro Tsuboyama, Koji Kamagata, Taiki Nozaki, Noriyuki Fujima, Mariko Kawamura, Shinji Naganawa

    Annals of nuclear medicine     2024.9

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    This review explores the potential applications of Large Language Models (LLMs) in nuclear medicine, especially nuclear medicine examinations such as PET and SPECT, reviewing recent advancements in both fields. Despite the rapid adoption of LLMs in various medical specialties, their integration into nuclear medicine has not yet been sufficiently explored. We first discuss the latest developments in nuclear medicine, including new radiopharmaceuticals, imaging techniques, and clinical applications. We then analyze how LLMs are being utilized in radiology, particularly in report generation, image interpretation, and medical education. We highlight the potential of LLMs to enhance nuclear medicine practices, such as improving report structuring, assisting in diagnosis, and facilitating research. However, challenges remain, including the need for improved reliability, explainability, and bias reduction in LLMs. The review also addresses the ethical considerations and potential limitations of AI in healthcare. In conclusion, LLMs have significant potential to transform existing frameworks in nuclear medicine, making it a critical area for future research and development.

    DOI: 10.1007/s12149-024-01981-x

    PubMed

  79. Response to letter to the editor from Dr. Muhammed Said Beşler: 'the accuracy of large language models in RANZCR's clinical radiology exam sample questions'.

    Takeshi Nakaura, Shinji Naganawa

    Japanese journal of radiology   Vol. 42 ( 9 ) page: 1081 - 1082   2024.9

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    DOI: 10.1007/s11604-024-01594-4

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  80. Imaging evaluation and volumetric measurement of the space surrounding the diploic veins.

    Rei Nakamichi, Toshiaki Taoka, Rintaro Ito, Tadao Yoshida, Michihiko Sone, Shinji Naganawa

    Japanese journal of radiology   Vol. 42 ( 9 ) page: 953 - 961   2024.9

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    PURPOSE: The diploic veins have been suggested to be involved in the excretion of cerebrospinal fluid and intracranial waste products; however, to date, there have been no reports evaluating the space surrounding the diploic veins. Therefore, we aimed to visualize the distribution of gadolinium-based contrast agent (GBCA) in the space surrounding the diploic veins and to evaluate the spatial characteristics. MATERIALS AND METHODS: Ninety-eight participants (aged 14-84 years) were scanned 4 h after intravenous GBCA injection at Nagoya University Hospital between April 2021 and December 2022. The volume of the space surrounding the diploic veins where the GBCA was distributed was measured using contrast-enhanced T1-weighted images with the application of three-axis motion-sensitized driven equilibrium. The parasagittal dura (PSD) volume adjacent to the superior sagittal sinus was also measured using the same images. Both volumes were corrected for intracranial volume. The correlation between age and the corrected volume was examined using Spearman's rank correlation coefficient; the relationship between the corrected volume and sex was assessed using the Mann-Whitney U test. RESULTS: A significant weak negative correlation was observed between the volume of the space surrounding the diploic veins and age (r = -0.330, p < 0.001). Furthermore, there was a significant weak positive correlation between the PSD volume and age (r = 0.385, p < 0.001). Both volumes were significantly greater in men than in women. There was no correlation between the volume of the space surrounding the diploic veins and the volume of the PSD. CONCLUSION: The volume of the space surrounding the diploic veins was measurable and, in contrast to the volume of the PSD, was greater in younger participants. This space may be related to intracranial excretory mechanisms and immune responses during youth, requiring further research.

    DOI: 10.1007/s11604-024-01572-w

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  81. Overview of Target-Oriented Project Group United for Nippon (TOP GUN): fostering interdisciplinary collaboration among young researchers in radiology on timely topics.

    Koji Kamagata, Shinji Naganawa

    Japanese journal of radiology   Vol. 42 ( 9 ) page: 935 - 936   2024.9

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    DOI: 10.1007/s11604-024-01580-w

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  82. Recent trends in AI applications for pelvic MRI: a comprehensive review

    Takahiro Tsuboyama, Masahiro Yanagawa, Tomoyuki Fujioka, Shohei Fujita, Daiju Ueda, Rintaro Ito, Akira Yamada, Yasutaka Fushimi, Fuminari Tatsugami, Takeshi Nakaura, Taiki Nozaki, Koji Kamagata, Yusuke Matsui, Kenji Hirata, Noriyuki Fujima, Mariko Kawamura, Shinji Naganawa

    La radiologia medica   Vol. 129 ( 9 ) page: 1275 - 1287   2024.9

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    DOI: 10.1007/s11547-024-01861-4

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    Other Link: https://link.springer.com/article/10.1007/s11547-024-01861-4/fulltext.html

  83. Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method.

    Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Toshiki Nakane, Hisashi Kawai, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 23 ( 3 ) page: 268 - 290   2024.7

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    More than 5 years have passed since the Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS) method was proposed with the intention of evaluating the glymphatic system. This method is handy due to its noninvasiveness, provision of a simple index in a straightforward formula, and the possibility of retrospective analysis. Therefore, the ALPS method was adopted to evaluate the glymphatic system for many disorders in many studies. The purpose of this review is to look back and discuss the ALPS method at this moment.The ALPS-index was found to be an indicator of a number of conditions related to the glymphatic system. Thus, although this was expected in the original report, the results of the ALPS method are often interpreted as uniquely corresponding to the function of the glymphatic system. However, a number of subsequent studies have pointed out the problems on the data interpretation. As they rightly point out, a higher ALPS-index indicates predominant Brownian motion of water molecules in the radial direction at the lateral ventricular body level, no more and no less. Fortunately, the term "ALPS-index" has become common and is now known as a common term by many researchers. Therefore, the ALPS-index should simply be expressed as high or low, and whether it reflects a glymphatic system is better to be discussed carefully. In other words, when a decreased ALPS-index is observed, it should be expressed as "decreased ALPS-index" and not directly as "glymphatic dysfunction". Recently, various methods have been proposed to evaluate the glymphatic system. It has become clear that these methods also do not seem to reflect the entirety of the extremely complex glymphatic system. This means that it would be desirable to use various methods in combination to evaluate the glymphatic system in a comprehensive manner.

    DOI: 10.2463/mrms.rev.2023-0175

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  84. The impact of large language models on radiology: a guide for radiologists on the latest innovations in AI.

    Takeshi Nakaura, Rintaro Ito, Daiju Ueda, Taiki Nozaki, Yasutaka Fushimi, Yusuke Matsui, Masahiro Yanagawa, Akira Yamada, Takahiro Tsuboyama, Noriyuki Fujima, Fuminari Tatsugami, Kenji Hirata, Shohei Fujita, Koji Kamagata, Tomoyuki Fujioka, Mariko Kawamura, Shinji Naganawa

    Japanese journal of radiology   Vol. 42 ( 7 ) page: 685 - 696   2024.7

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    The advent of Deep Learning (DL) has significantly propelled the field of diagnostic radiology forward by enhancing image analysis and interpretation. The introduction of the Transformer architecture, followed by the development of Large Language Models (LLMs), has further revolutionized this domain. LLMs now possess the potential to automate and refine the radiology workflow, extending from report generation to assistance in diagnostics and patient care. The integration of multimodal technology with LLMs could potentially leapfrog these applications to unprecedented levels.However, LLMs come with unresolved challenges such as information hallucinations and biases, which can affect clinical reliability. Despite these issues, the legislative and guideline frameworks have yet to catch up with technological advancements. Radiologists must acquire a thorough understanding of these technologies to leverage LLMs' potential to the fullest while maintaining medical safety and ethics. This review aims to aid in that endeavor.

    DOI: 10.1007/s11604-024-01552-0

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  85. Evaluation of alterations in interstitial fluid dynamics in cases of whole-brain radiation using the diffusion-weighted image analysis along the perivascular space method. International journal

    Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Toshiki Nakane, Mariko Kawamura, Shunichi Ishihara, Kazushige Ichikawa, Hisashi Kawai, Shinji Naganawa

    NMR in biomedicine   Vol. 37 ( 7 ) page: e5030   2024.7

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    In the current study, we assessed changes in interstitial fluid dynamics resulting after whole-brain radiotherapy using the diffusion-weighted image analysis along the perivascular space (DWI-ALPS) method, which is a simplified variation of the diffusion tensor image ALPS (DTI-ALPS) method using diffusion-weighted imaging (DWI) with orthogonal motion-probing gradients (MPGs). This retrospective study included 47 image sets from 22 patients who underwent whole-brain radiotherapy for brain tumors. The data for the normal control group comprised 105 image sets from 105 participants with no pathological changes. DWI was performed with the three MPGs applied in an orthogonal direction to the imaging plane, and apparent diffusion coefficient images for the x-, y-, and z-axes were retrospectively generated. The ALPS index was calculated to quantify interstitial fluid dynamics. The independent t-test was used to compare the ALPS index between normal controls and patients who underwent whole-brain radiotherapy. Patients were compared in all age groups and individual age groups (20-39, 40-59, and 60-84 years). We also examined the correlation between biologically equivalent doses (BEDs) and the ALPS index, as well as the correlation between white matter hyperintensity and the ALPS index. In the comparison of all age groups, the ALPS index was significantly lower (p < 0.001) in the postradiation group (1.32 ± 0.16) than in the control group (1.44 ± 0.17), suggesting that interstitial fluid dynamics were altered in patients following whole-brain radiotherapy. Significant age group differences were found (40-59 years: p < 0.01; 60-84 years: p < 0.001), along with a weak negative correlation between BEDs (r = -0.19) and significant correlations between white matter hyperintensity and the ALPS index (r = -0.46 for periventricular white matter, r = -0.38 for deep white matter). It was concluded that the ALPS method using DWI with orthogonal MPGs suggest alteration in interstitial fluid dynamics in patients after whole-brain radiotherapy. Further systematic prospective studies are required to investigate their association with cognitive symptoms.

    DOI: 10.1002/nbm.5030

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  86. Climate change and artificial intelligence in healthcare: Review and recommendations towards a sustainable future

    Daiju Ueda, Shannon L Walston, Shohei Fujita, Yasutaka Fushimi, Takahiro Tsuboyama, Koji Kamagata, Akira Yamada, Masahiro Yanagawa, Rintaro Ito, Noriyuki Fujima, Mariko Kawamura, Takeshi Nakaura, Yusuke Matsui, Fuminari Tatsugami, Tomoyuki Fujioka, Taiki Nozaki, Kenji Hirata, Shinji Naganawa

    Diagnostic and Interventional Imaging     2024.6

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    DOI: 10.1016/j.diii.2024.06.002

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  87. Palliative radiotherapy for painful non-bone lesions in patients with advanced cancer: a single center retrospective study

    Yurika Shindo, Yutaro Koide, Naoya Nagai, Tomoki Kitagawa, Takahiro Aoyama, Hidetoshi Shimizu, Shingo Hashimoto, Hiroyuki Tachibana, Takeshi Kodaira, Shunichi Ishihara, Shinji Naganawa

    Japanese Journal of Radiology   Vol. 42 ( 6 ) page: 656 - 661   2024.6

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    Abstract

    Purpose

    This retrospective study aimed to assess the efficacy and safety of palliative radiotherapy for painful non-bone lesions in patients with advanced cancer.

    Materials and methods

    We enrolled patients with painful non-bone lesions who underwent conventional palliative radiotherapy between September 2018 and September 2022. The treatment targets included primary tumor lesions, lymph node metastases, non-bone hematogenous metastases, and other lesions. The primary endpoint was the overall pain response rate in evaluable patients, determined based on the International Consensus Pain Response Endpoint criteria. The secondary endpoints included overall survival, pain recurrence, and adverse events.

    Results

    Of the 420 screened patients, 142 received palliative radiotherapy for painful non-bone lesions, and 112 were evaluable. A pain response was achieved in 67 patients (60%) of the 112 evaluable patients within a median of 1.2 months. Among these patients, 25 exhibited complete response, 42 partial response, 18 indeterminate response, and 27 pain progression. The median survival time was 5.5 months, recorded at a median follow-up of 6.0 months, during which 67 patients died. Multivariate analysis identified poor performance status scores of 2–4, opioid use, and re-irradiation as independent factors associated with a reduced likelihood of achieving a pain response. Pain recurrence occurred in 18 patients over a median of 4.1 months. Seventeen patients had grade 1–2 adverse events, while none experienced grade 3 or higher toxicity.

    Conclusion

    Palliative radiotherapy can potentially be a safe and well-tolerated modality for managing painful non-bone lesions, with a low rate of adverse events.

    DOI: 10.1007/s11604-024-01536-0

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    Other Link: https://link.springer.com/article/10.1007/s11604-024-01536-0/fulltext.html

  88. Decreased diffusivity along the perivascular space and cerebral hemodynamic disturbance in adult moyamoya disease

    Shoko Hara, Junko Kikuta, Kaito Takabayashi, Koji Kamagata, Shihori Hayashi, Motoki Inaji, Yoji Tanaka, Masaaki Hori, Kenji Ishii, Tadashi Nariai, Toshiaki Taoka, Shinji Naganawa, Shigeki Aoki, Taketoshi Maehara

    Journal of Cerebral Blood Flow &amp; Metabolism     page: 271678X241245492   2024.4

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    Moyamoya disease (MMD) causes cerebral arterial stenosis and hemodynamic disturbance, the latter of which may disrupt glymphatic system activity, the waste clearance system. We evaluated 46 adult patients with MMD and 33 age- and sex-matched controls using diffusivity along the perivascular space (ALPS) measured with diffusion tensor imaging (ALPS index), which may partly reflect glymphatic system activity, and multishell diffusion MRI to generate freewater maps. Twenty-three patients were also evaluated via <sup>15</sup>O-gas positron emission tomography (PET), and all patients underwent cognitive tests. Compared to controls, patients (38.4 (13.2) years old, 35 females) had lower ALPS indices in the left and right hemispheres (1.94 (0.27) vs. 1.65 (0.25) and 1.94 (0.22) vs. 1.65 (0.19), P &lt; 0.001). While the right ALPS index showed no correlation, the left ALPS index was correlated with parenchymal freewater ( ρ = −0.47, P &lt; 0.001); perfusion measured with PET (cerebral blood flow, ρ = 0.70, P &lt; 0.001; mean transit time, ρ = −0.60, P = 0.003; and oxygen extraction fraction, ρ = −0.52, P = 0.003); and cognitive tests (trail making test part B for executive function; ρ = −0.37, P = 0.01). Adult patients with MMD may exhibit decreased glymphatic system activity, which is correlated with the degree of hemodynamic disturbance, increased interstitial freewater, and cognitive dysfunction, but further investigation is needed.

    DOI: 10.1177/0271678X241245492

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    Other Link: https://journals.sagepub.com/doi/full-xml/10.1177/0271678X241245492

  89. Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging.

    Shinji Naganawa, Rintaro Ito, Mariko Kawamura, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2024.4

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    PURPOSE: The endolymph of the inner ear, vital for balance and hearing, has long been considered impermeable to intravenously administered gadolinium-based contrast agents (GBCAs) due to the tight blood-endolymph barrier. However, anecdotal observations suggested potential GBCA entry in delayed heavily T2-weighted 3D-real inversion recovery (IR) MRI scans. This study systematically investigated GBCA distribution in the endolymph using this 3D-real IR sequence. METHODS: Forty-one patients suspected of endolymphatic hydrops (EHs) underwent pre-contrast, 4-h, and 24-h post-contrast 3D-real IR imaging. Signal intensity in cerebrospinal fluid (CSF), perilymph, and endolymph was measured and analyzed for temporal dynamics of GBCA uptake, correlations between compartments, and the influence of age and presence of EH. RESULTS: Endolymph showed a delayed peak GBCA uptake at 24h, contrasting with peaks in perilymph and CSF at 4h. Weak to moderate positive correlations between endolymph and CSF contrast effect were observed at both 4 (r = 0.483) and 24h (r = 0.585), suggesting possible inter-compartmental interactions. Neither the presence of EH nor age significantly influenced endolymph enhancement. However, both perilymph and CSF contrast effects significantly correlated with age at both time points. CONCLUSION: This study provides the first in vivo systematic confirmation of GBCA entering the endolymph following intravenous administration. Notably, endolymph uptake peaked at 24h, significantly later than perilymph and CSF. The lack of a link between endolymph contrast and both perilymph and age suggests distinct uptake mechanisms. These findings shed light on inner ear fluid dynamics and their potential implications in Ménière's disease and other inner ear disorders.

    DOI: 10.2463/mrms.mp.2024-0011

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  90. Evaluation of 4D Flow MRI-Derived Relative Residence Time as a Marker for Cirrhosis Associated Portal Vein Thrombosis. Reviewed International journal

    Ryota Hyodo, Yasuo Takehara, Yoji Ishizu, Kazuki Nishida, Takashi Mizuno, Kazushige Ichikawa, Ryota Horiguchi, Nobuhiko Kurata, Yasuhiro Ogura, Shinya Yokoyama, Shinji Naganawa, Ning Jin, Yoshito Ichiba

    Journal of magnetic resonance imaging : JMRI     2024.3

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    BACKGROUND: Portal vein thrombosis (PVT) is thought to arise from stagnant blood flow, yet conclusive evidence is lacking. Relative residence time (RRT) assessed using 4D Flow MRI may offer insight into portal flow stagnation. PURPOSE: To explore the relationship between RRT values and the presence of PVT in cirrhotic participants. STUDY TYPE: Prospective. POPULATION: Forty-eight participants with liver cirrhosis (27 males, median age 67 years [IQR: 57-73]) and 20 healthy control participants (12 males, median age 45 years [IQR: 40-54]). FIELD STRENGTH/SEQUENCE: 3 T/4D Flow MRI. ASSESSMENT: Laboratory (liver and kidney function test results and platelet count) and clinical data (presence of tumors and other imaging findings), and portal hemodynamics derived from 4D Flow MRI (spatiotemporally averaged RRT [RRT-mean], flow velocity, and flow rate) were analyzed. STATISTICAL TESTS: We used multivariable logistic regression, adjusted by selected covariates through the Lasso method, to explore whether RRT-mean is an independent risk factor for PVT. The area under the ROC curve (AUC) was also calculated to assess the model's discriminative ability. P < 0.05 indicated statistical significance. RESULTS: The liver cirrhosis group consisted of 16 participants with PVT and 32 without PVT. Higher RRT-mean values (odds ratio [OR] 11.4 [95% CI: 2.19, 118]) and lower platelet count (OR 0.98 per 1000 μL [95% CI: 0.96, 0.99]) were independent risk factors for PVT. The incorporation of RRT-mean (AUC, 0.77) alongside platelet count (AUC, 0.75) resulted in an AUC of 0.84. When including healthy control participants, RRT-mean had an adjusted OR of 12.4 and the AUC of the combined model (RRT-mean and platelet count) was 0.90. DATA CONCLUSION: Prolonged RRT values and low platelet count were significantly associated with the presence of PVT in cirrhotic participants. RRT values derived from 4D Flow MRI may have potential clinical relevance in the management of PVT. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.

    DOI: 10.1002/jmri.29357

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  91. Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome. Reviewed International journal

    Nivedita Agarwal, Laura D Lewis, Lydiane Hirschler, Leonardo Rivera Rivera, Shinji Naganawa, Swati Rane Levendovszky, Geir Ringstad, Marijan Klarica, Joanna Wardlaw, Costantino Iadecola, Cheryl Hawkes, Roxana Octavia Carare, Jack Wells, Erik N T P Bakker, Vartan Kurtcuoglu, Lynne Bilston, Maiken Nedergaard, Yuki Mori, Marcus Stoodley, Noam Alperin, Mony de Leon, Matthias J P van Osch

    JOURNAL OF MAGNETIC RESONANCE IMAGING   Vol. 59 ( 2 ) page: 431 - 449   2024.2

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    Neurofluids is a term introduced to define all fluids in the brain and spine such as blood, cerebrospinal fluid, and interstitial fluid. Neuroscientists in the past millennium have steadily identified the several different fluid environments in the brain and spine that interact in a synchronized harmonious manner to assure a healthy microenvironment required for optimal neuroglial function. Neuroanatomists and biochemists have provided an incredible wealth of evidence revealing the anatomy of perivascular spaces, meninges and glia and their role in drainage of neuronal waste products. Human studies have been limited due to the restricted availability of noninvasive imaging modalities that can provide a high spatiotemporal depiction of the brain neurofluids. Therefore, animal studies have been key in advancing our knowledge of the temporal and spatial dynamics of fluids, for example, by injecting tracers with different molecular weights. Such studies have sparked interest to identify possible disruptions to neurofluids dynamics in human diseases such as small vessel disease, cerebral amyloid angiopathy, and dementia. However, key differences between rodent and human physiology should be considered when extrapolating these findings to understand the human brain. An increasing armamentarium of noninvasive MRI techniques is being built to identify markers of altered drainage pathways. During the three-day workshop organized by the International Society of Magnetic Resonance in Medicine that was held in Rome in September 2022, several of these concepts were discussed by a distinguished international faculty to lay the basis of what is known and where we still lack evidence. We envision that in the next decade, MRI will allow imaging of the physiology of neurofluid dynamics and drainage pathways in the human brain to identify true pathological processes underlying disease and to discover new avenues for early diagnoses and treatments including drug delivery. Evidence level: 1 Technical Efficacy: Stage 3.

    DOI: 10.1002/jmri.28759

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  92. Revolutionizing radiation therapy: the role of AI in clinical practice Reviewed

    Mariko Kawamura, Takeshi Kamomae, Masahiro Yanagawa, Koji Kamagata, Shohei Fujita, Daiju Ueda, Yusuke Matsui, Yasutaka Fushimi, Tomoyuki Fujioka, Taiki Nozaki, Akira Yamada, Kenji Hirata, Rintaro Ito, Noriyuki Fujima, Fuminari Tatsugami, Takeshi Nakaura, Takahiro Tsuboyama, Shinji Naganawa

    Journal of Radiation Research   Vol. 65 ( 1 ) page: 1 - 9   2024.1

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    Abstract

    This review provides an overview of the application of artificial intelligence (AI) in radiation therapy (RT) from a radiation oncologist’s perspective. Over the years, advances in diagnostic imaging have significantly improved the efficiency and effectiveness of radiotherapy. The introduction of AI has further optimized the segmentation of tumors and organs at risk, thereby saving considerable time for radiation oncologists. AI has also been utilized in treatment planning and optimization, reducing the planning time from several days to minutes or even seconds. Knowledge-based treatment planning and deep learning techniques have been employed to produce treatment plans comparable to those generated by humans. Additionally, AI has potential applications in quality control and assurance of treatment plans, optimization of image-guided RT and monitoring of mobile tumors during treatment. Prognostic evaluation and prediction using AI have been increasingly explored, with radiomics being a prominent area of research. The future of AI in radiation oncology offers the potential to establish treatment standardization by minimizing inter-observer differences in segmentation and improving dose adequacy evaluation. RT standardization through AI may have global implications, providing world-standard treatment even in resource-limited settings. However, there are challenges in accumulating big data, including patient background information and correlating treatment plans with disease outcomes. Although challenges remain, ongoing research and the integration of AI technology hold promise for further advancements in radiation oncology.

    DOI: 10.1093/jrr/rrad090

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  93. Interstitial Fluidopathy of the Central Nervous System: An Umbrella Term for Disorders with Impaired Neurofluid Dynamics. Reviewed

    Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Toshiki Nakane, Hisashi Kawai, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 23 ( 1 ) page: 1 - 13   2024.1

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    Interest in interstitial fluid dynamics has increased since the proposal of the glymphatic system hypothesis. Abnormal dynamics of the interstitial fluid have been pointed out to be an important factor in various pathological statuses. In this article, we propose the concept of central nervous system interstitial fluidopathy as a disease or condition in which abnormal interstitial fluid dynamics is one of the important factors for the development of a pathological condition. We discuss the aspects of interstitial fluidopathy in various diseases, including Alzheimer's disease, Parkinson's disease, normal pressure hydrocephalus, and cerebral small vessel disease. We also discuss a method called "diffusion tensor image analysis along the perivascular space" using MR diffusion images, which is used to evaluate the degree of interstitial fluidopathy or the activity of the glymphatic system.

    DOI: 10.2463/mrms.rev.2022-0012

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  94. Fairness of artificial intelligence in healthcare: review and recommendations Reviewed

    Daiju Ueda, Taichi Kakinuma, Shohei Fujita, Koji Kamagata, Yasutaka Fushimi, Rintaro Ito, Yusuke Matsui, Taiki Nozaki, Takeshi Nakaura, Noriyuki Fujima, Fuminari Tatsugami, Masahiro Yanagawa, Kenji Hirata, Akira Yamada, Takahiro Tsuboyama, Mariko Kawamura, Tomoyuki Fujioka, Shinji Naganawa

    Japanese Journal of Radiology   Vol. 42 ( 1 ) page: 3 - 15   2024.1

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    In this review, we address the issue of fairness in the clinical integration of artificial intelligence (AI) in the medical field. As the clinical adoption of deep learning algorithms, a subfield of AI, progresses, concerns have arisen regarding the impact of AI biases and discrimination on patient health. This review aims to provide a comprehensive overview of concerns associated with AI fairness; discuss strategies to mitigate AI biases; and emphasize the need for cooperation among physicians, AI researchers, AI developers, policymakers, and patients to ensure equitable AI integration. First, we define and introduce the concept of fairness in AI applications in healthcare and radiology, emphasizing the benefits and challenges of incorporating AI into clinical practice. Next, we delve into concerns regarding fairness in healthcare, addressing the various causes of biases in AI and potential concerns such as misdiagnosis, unequal access to treatment, and ethical considerations. We then outline strategies for addressing fairness, such as the importance of diverse and representative data and algorithm audits. Additionally, we discuss ethical and legal considerations such as data privacy, responsibility, accountability, transparency, and explainability in AI. Finally, we present the Fairness of Artificial Intelligence Recommendations in healthcare (FAIR) statement to offer best practices. Through these efforts, we aim to provide a foundation for discussing the responsible and equitable implementation and deployment of AI in healthcare.

    DOI: 10.1007/s11604-023-01474-3

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  95. The Glymphatic System in Humans: Investigations With Magnetic Resonance Imaging. Reviewed International journal

    Shinji Naganawa, Toshiaki Taoka, Rintaro Ito, Mariko Kawamura

    Investigative radiology   Vol. 59 ( 1 ) page: 1 - 12   2024.1

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    The concept of the glymphatic system was proposed more than a decade ago as a mechanism for interstitial fluid flow and waste removal in the central nervous system. The function of the glymphatic system has been shown to be particularly activated during sleep. Dysfunction of the glymphatic system has been implicated in several neurodegenerative diseases. Noninvasive in vivo imaging of the glymphatic system is expected to be useful in elucidating the pathophysiology of these diseases. Currently, magnetic resonance imaging is the most commonly used technique to evaluate the glymphatic system in humans, and a large number of studies have been reported. This review provides a comprehensive overview of investigations of the human glymphatic system function using magnetic resonance imaging. The studies can be divided into 3 categories, including imaging without gadolinium-based contrast agents (GBCAs), imaging with intrathecal administration of GBCAs, and imaging with intravenous administration of GBCAs. The purpose of these studies has been to examine not only the interstitial fluid movement in the brain parenchyma, but also the fluid dynamics in the perivascular and subarachnoid spaces, as well as the parasagittal dura and meningeal lymphatics. Recent research has even extended to include the glymphatic system of the eye and the inner ear. This review serves as an important update and a useful guide for future research directions.

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  96. Glymphatic System Dysfunction in Myelin Oligodendrocyte Glycoprotein Immunoglobulin G Antibody-Associated Disorders: Association with Clinical Disability. Reviewed International journal

    Akifumi Hagiwara, Yuji Tomizawa, Yasunobu Hoshino, Kazumasa Yokoyama, Koji Kamagata, Towa Sekine, Kaito Takabayashi, Moto Nakaya, Tomoko Maekawa, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Nobutaka Hattori, Shigeki Aoki

    AJNR. American journal of neuroradiology   Vol. 45 ( 1 ) page: 66 - 71   2024.1

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    BACKGROUND AND PURPOSE: Impaired glymphatic function has been suggested to be implicated in the pathophysiology of MS and aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorder. This study aimed to investigate the interstitial fluid dynamics in the brain in patients with myelin oligodendrocyte glycoprotein antibody disorders (MOGAD), another demyelinating disorder, using a noninvasive imaging technique called the diffusivity along the perivascular space (ALPS) index. MATERIALS AND METHODS: A prospective study was conducted on 16 patients with MOGAD in remission and 22 age- and sex-matched healthy control subjects. MR imaging was performed using a 3T scanner, and the ALPS index was calculated using diffusion MR imaging data with a b-value of 1000 s/mm2. The ALPS index and gray matter volumes were compared between the 2 groups, and these parameters were correlated with the Expanded Disability Status Scale. RESULTS: The mean ALPS index of patients with MOGAD was significantly lower than that of healthy controls (Cohen d = 0.93, false discovery rate-corrected P = .02). The lower mean ALPS index was significantly associated with a worse Expanded Disability Status Scale score (Spearman ρ = -0.51; 95% CI, -0.85 to -0.02; P = .03). However, cortical volume and deep gray matter volume were not significantly different between the 2 groups, and they were not correlated with the Expanded Disability Status Scale. CONCLUSIONS: This study suggests that patients with MOGAD may have impaired glymphatic function, as measured by the ALPS index, which is associated with patient disability. Further study is warranted with a larger sample size.

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  97. Association between the Putative Meningeal Lymphatics at the Posterior Wall of the Sigmoid Sinus and Delayed Contrast-agent Elimination from the Cerebrospinal Fluid.

    Shinji Naganawa, Rintaro Ito, Mariko Kawamura, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 23 ( 1 ) page: 80 - 91   2024

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    PURPOSE: To investigate the characteristics of the putative meningeal lymphatics located at the posterior wall of the sigmoid sinus (PML-PSS) in human subjects imaged before and after intravenous administration (IV) of a gadolinium-based contrast agent (GBCA). The appearance of the PML-PSS and the enhancement of the perivascular space of the basal ganglia (PVS-BG) were analyzed for an association with gender, age, and clearance of the GBCA from the cerebrospinal fluid (CSF). METHODS: Forty-two patients with suspected endolymphatic hydrops were included. Heavily T2-weighted 3D-fluid attenuated inversion recovery (hT2w-3D-FLAIR) and 3D-real inversion recovery (IR) images were obtained at pre-administration, immediately post-administration, and at 4 and 24 hours after IV-GBCA. The appearance of the PML-PSS and the presence of enhancement in the PVS-BG were analyzed for a relationship with age, gender, contrast enhancement of the CSF at 4 hours after IV-GBCA, and the washout ratio of the GBCA in the CSF from 4 to 24 hours after IV-GBCA. RESULTS: The PML-PSS and PVS-BG were seen in 23 of 42 and 21 of 42 cases, respectively, at 4 hours after IV-GBCA. In all PML-PSS positive cases, hT2w-3D-FLAIR signal enhancement was highest at 4 hours after IV-GBCA. A multivariate analysis between gender, age, CSF signal elevation at 4 hours, and washout ratio indicated that only the washout ratio was independently associated with the enhancement of the PML-PSS or PVS-BG. The odds ratios (95% CIs; P value) were 4.09 × 10-5 (2.39 × 10-8 - 0.07; 0.0078) for the PML-PSS and 1.7 × 10-4 (1.66 × 10-7 - 0.174; 0.014) for the PVS-BG. CONCLUSION: The PML-PSS had the highest signal enhancement at 4 hours after IV-GBCA. When the PML-PSS was seen, there was also often enhancement of the PVS-BG at 4 hours after IV-GBCA. Both observed enhancements were associated with delayed GBCA excretion from the CSF.

    DOI: 10.2463/mrms.mp.2022-0110

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  98. Assessing the Real-World, Long-Term Impact of Lemborexant on Sleep Quality in a Home-Based Clinical Study. International journal

    Seiko Miyata, Kunihiro Iwamoto, Ippei Okada, Akihiro Fujimoto, Yuki Kogo, Daisuke Mori, Manabu Amano, Nao Matsuyama, Kazuki Nishida, Masahiko Ando, Toshiaki Taoka, Shinji Naganawa, Norio Ozaki

    Nature and science of sleep   Vol. 16   page: 291 - 303   2024

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    PURPOSE: Both subjective and objective evaluations are essential for the treatment of insomnia. Lemborexant has been shown to be effective in the long-term based solely on a subjective basis, and no long-term objective measures have been evaluated under natural sleep conditions. Small, lightweight sleep electroencephalogram (EEG) monitor was used, instead of polysomnography, to objectively evaluate sleep at home 4 and 12 weeks after lemborexant treatment. PATIENTS AND METHODS: Adults and elderly subjects with insomnia disorder, per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, were enrolled in this open-label, single-arm, single-center trial. Objective and subjective measures of sleep were prospectively assessed. Sleep disturbance, excessive sleepiness, and depressive symptoms were assessed using questionnaires. RESULTS: A total of 45 subjects were screened, of which 33 were enrolled. Paired t-tests were conducted to evaluate changes in sleep variables and compared with the baseline; subjects showed significant improvements in objective sleep efficiency (SE) and subjective sleep parameters at weeks 4 and 12 following treatment with lemborexant. When baseline values were taken into account, a repeated-multivariate analysis of variance (MANOVA) revealed statistically significant changes in the objective measures. Sleep disturbance, excessive sleepiness, and depressive symptoms improved after three months of lemborexant treatment. CONCLUSION: Furthermore, lemborexant therapy improved nocturnal sleep, when measured objectively using sleep EEG monitoring at home, and improved daytime sleepiness and depressive symptoms in older adults with insomnia disorder.

    DOI: 10.2147/NSS.S448871

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  99. Assessing interstitial fluid dynamics in type 2 diabetes mellitus and prediabetes cases through diffusion tensor imaging analysis along the perivascular space

    Rukeye Tuerxun, Koji Kamagata, Yuya Saito, Christina Andica, Kaito Takabayashi, Wataru Uchida, Seina Yoshida, Junko Kikuta, Hiroki Tabata, Hitoshi Naito, Yuki Someya, Hideyoshi Kaga, Mari Miyata, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Shigeki Aoki

    Frontiers in Aging Neuroscience   Vol. 16   page: 1362457   2024

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    Background and purpose

    Glymphatic system in type 2 diabetes mellitus (T2DM) but not in the prodrome, prediabetes (Pre-DM) was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS). Association between glymphatic system and insulin resistance of prominent characteristic in T2DM and Pre-DM between is yet elucidated. Therefore, this study delves into the interstitial fluid dynamics using the DTI-ALPS in both Pre-DM and T2DM and association with insulin resistance.

    Materials and methods

    In our cross-sectional study, we assessed 70 elderly individuals from the Bunkyo Health Study, which included 22 with Pre-DM, 18 with T2DM, and 33 healthy controls with normal glucose metabolism (NGM). We utilized the general linear model (GLM) to evaluate the ALPS index based on DTI-ALPS across these groups, considering variables like sex, age, intracranial volume, years of education, anamnesis of hypertension and hyperlipidemia, and the total Fazekas scale. Furthermore, we have explored the relationship between the ALPS index and insulin resistance, as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) using GLM and the same set of covariates.

    Results

    In the T2DM group, the ALPS index demonstrated a reduction compared with the NGM group [family-wise error (FWE)-corrected p &amp;lt; 0.001; Cohen's d = −1.32]. Similarly, the Pre-DM group had a lower ALPS index than the NGM group (FWE-corrected p &amp;lt; 0.001; Cohen's d = −1.04). However, there was no significant disparity between the T2DM and Pre-DM groups (FWE-corrected p = 1.00; Cohen's d = −0.63). A negative correlation was observed between the ALPS index and HOMA-IR in the combined T2DM and Pre-DM groups (partial correlation coefficient r = −0.35, p &amp;lt; 0.005).

    Conclusion

    The ALPS index significantly decreased in both the pre-DM and T2DM groups and showed a correlated with insulin resistance. This indicated that changes in interstitial fluid dynamics are associated with insulin resistance.

    DOI: 10.3389/fnagi.2024.1362457

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  100. Measurement of solid size in early-stage lung adenocarcinoma by virtual 3D thin-section CT applied artificial intelligence. Reviewed International journal

    Shingo Iwano, Shinichiro Kamiya, Rintaro Ito, Akira Kudo, Yoshiro Kitamura, Keigo Nakamura, Shinji Naganawa

    Scientific reports   Vol. 13 ( 1 ) page: 21709 - 21709   2023.12

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    An artificial intelligence (AI) system that reconstructs virtual 3D thin-section CT (TSCT) images from conventional CT images by applying deep learning was developed. The aim of this study was to investigate whether virtual and real TSCT could measure the solid size of early-stage lung adenocarcinoma. The pair of original thin-CT and simulated thick-CT from the training data with TSCT images (thickness, 0.5-1.0 mm) of 2700 pulmonary nodules were used to train the thin-CT generator in the generative adversarial network (GAN) framework and develop a virtual TSCT AI system. For validation, CT images of 93 stage 0-I lung adenocarcinomas were collected, and virtual TSCTs were reconstructed from conventional 5-mm thick-CT images using the AI system. Two radiologists measured and compared the solid size of tumors on conventional CT and virtual and real TSCT. The agreement between the two observers showed an almost perfect agreement on the virtual TSCT for solid size measurements (intraclass correlation coefficient = 0.967, P < 0.001, respectively). The virtual TSCT had a significantly stronger correlation than that of conventional CT (P = 0.003 and P = 0.001, respectively). The degree of agreement between the clinical T stage determined by virtual TSCT and the clinical T stage determined by real TSCT was excellent in both observers (k = 0.882 and k = 0.881, respectively). The AI system developed in this study was able to measure the solid size of early-stage lung adenocarcinoma on virtual TSCT as well as on real TSCT.

    DOI: 10.1038/s41598-023-48755-5

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  101. 第1章 画像診断機器 【基調論文】最新医療機器の現況と将来的方向性 2024年 最新医療機器の現状と展望 CTやMRIなどの画像診断装置の技術的到達点への評価と課題 Reviewed

    長縄慎二

    月間新医療データブック・シリーズ 医療機器システム白書 2024     page: 8 - 11   2023.12

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  102. 公益社団法人愛知県医師会「現代医学」誌70巻号の特集テーマ「がん検診」座談会 Invited Reviewed

    長縄慎二

    現代醫学   Vol. 70 ( 2 ) page: 1 - 13   2023.12

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  103. Intracranial Air Absorption through Arachnoid Granulation: New Considerations from Transsphenoidal Surgery and Implications for Neurofluid Dynamics. Reviewed

    Shinji Naganawa, Rintaro Ito, Mariko Kawamura, Toshiaki Taoka

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2023.11

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    Postsurgery intracranial air usually diminishes, presumably merging with cerebrospinal fluid (CSF) and venous circulation. Our study presents two transsphenoidal surgery cases, highlighting potential air absorption by arachnoid granulation (AG)-an underexplored phenomenon. AG has long been deemed pivotal for CSF absorption, but recent perspectives suggest a significant role in waste clearance, neuroinflammation, and neuroimmunity. These cases may stimulate renewed research on the multifaceted role of AG in neurofluid dynamics and potentially elucidate further AG functions.

    DOI: 10.2463/mrms.bc.2023-0122

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  104. Recent advances in artificial intelligence for cardiac CT: Enhancing diagnosis and prognosis prediction Reviewed

    Fuminari Tatsugami, Takeshi Nakaura, Masahiro Yanagawa, Shohei Fujita, Koji Kamagata, Rintaro Ito, Mariko Kawamura, Yasutaka Fushimi, Daiju Ueda, Yusuke Matsui, Akira Yamada, Noriyuki Fujima, Tomoyuki Fujioka, Taiki Nozaki, Takahiro Tsuboyama, Kenji Hirata, Shinji Naganawa

    Diagnostic and Interventional Imaging   Vol. 104 ( 11 ) page: 521 - 528   2023.11

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    DOI: 10.1016/j.diii.2023.06.011

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  105. <Editors' Choice> Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function. Reviewed

    Yusuke Yoshida, Takamasa Yokoi, Kazuhiro Hara, Hirohisa Watanabe, Hiroshi Yamaguchi, Epifanio Bagarinao, Michihito Masuda, Toshiyasu Kato, Aya Ogura, Reiko Ohdake, Kazuya Kawabata, Masahisa Katsuno, Katsuhiko Kato, Shinji Naganawa, Nobuyuki Okamura, Kazuhiko Yanai, Gen Sobue

    Nagoya journal of medical science   Vol. 85 ( 4 ) page: 758 - 771   2023.11

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    We aimed to elucidate the distribution pattern of the positron emission tomography probe [18F]THK 5351, a marker for astrogliosis and tau accumulation, in healthy aging. We also assessed the relationship between THK5351 retention and resting state networks. We enrolled 62 healthy participants in this study. All participants underwent magnetic resonance imaging/positron emission tomography scanning consisting of T1-weighted images, resting state functional magnetic resonance imaging, Pittsburgh Compound-B and THK positron emission tomography. The preprocessed THK images were entered into a scaled subprofile modeling/principal component analysis to extract THK distribution patterns. Using the most significant THK pattern, we generated regions of interest, and performed seed-based functional connectivity analyses. We also evaluated the functional connectivity overlap ratio to identify regions with high between-network connectivity. The most significant THK distributions were observed in the medial prefrontal cortex and bilateral putamen. The seed regions of interest in the medial prefrontal cortex had a functional connectivity map that significantly overlapped with regions of the dorsal default mode network. The seed regions of interest in the putamen showed strong overlap with the basal ganglia and anterior salience networks. The functional connectivity overlap ratio also showed that three peak regions had the characteristics of connector hubs. We have identified an age-related spatial distribution of THK in the medial prefrontal cortex and basal ganglia in normal aging. Interestingly, the distribution's peaks are located in regions of connector hubs that are strongly connected to large-scale resting state networks associated with higher cognitive function.

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  106. From FDG and beyond: the evolving potential of nuclear medicine. Reviewed

    Kenji Hirata, Koji Kamagata, Daiju Ueda, Masahiro Yanagawa, Mariko Kawamura, Takeshi Nakaura, Rintaro Ito, Fuminari Tatsugami, Yusuke Matsui, Akira Yamada, Yasutaka Fushimi, Taiki Nozaki, Shohei Fujita, Tomoyuki Fujioka, Takahiro Tsuboyama, Noriyuki Fujima, Shinji Naganawa

    Annals of nuclear medicine   Vol. 37 ( 11 ) page: 583 - 595   2023.11

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    The radiopharmaceutical 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) has been dominantly used in positron emission tomography (PET) scans for over 20 years, and due to its vast utility its applications have expanded and are continuing to expand into oncology, neurology, cardiology, and infectious/inflammatory diseases. More recently, the addition of artificial intelligence (AI) has enhanced nuclear medicine diagnosis and imaging with FDG-PET, and new radiopharmaceuticals such as prostate-specific membrane antigen (PSMA) and fibroblast activation protein inhibitor (FAPI) have emerged. Nuclear medicine therapy using agents such as [177Lu]-dotatate surpasses conventional treatments in terms of efficacy and side effects. This article reviews recently established evidence of FDG and non-FDG drugs and anticipates the future trajectory of nuclear medicine.

    DOI: 10.1007/s12149-023-01865-6

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  107. Diffusivity Along the Perivascular Space is Decreased and Related to Hypoperfusion in Adult Moyamoya disease Reviewed

    Shoko Hara, Junko Kikuta, Kaito Takabayashi, Koji Kamagata, Shihori Hayashi, Motoki Inaji, Yoji Tanaka, Masaaki Hori, Kenji Ishii, Tadashi Nariai, Toshiaki Taoka, Shinji Naganawa, Shigeki Aoki, Taketoshi Maehara

    in press (https://www.researchsquare.com/article/rs-3411760/v1)     2023.10

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    DOI: 10.21203/rs.3.rs-3411760/v1

  108. Multisite harmonization of diffusion tensor image analysis along the perivascular space using the COMBined Association Test. Reviewed

    Yuya Saito, Koji Kamagata, Christina Andica, Toshiaki Taoka, Rukeye Tuerxun, Wataru Uchida, Kaito Takabayashi, Mana Owaki, Seina Yoshida, Keigo Yamazaki, Shinji Naganawa, Shigeki Aoki

    Japanese journal of radiology   Vol. 41 ( 10 ) page: 1072 - 1083   2023.10

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    PURPOSE: This multisite study aimed to use the COMBined Association Test (COMBAT), a harmonization technique that uses regression of covariates with an empirical Bayesian framework, to harmonize diffusion tensor image analysis along the perivascular space (DTI-ALPS) variations caused by scanner, site, and protocol differences. MATERIALS AND METHODS: This study included multisite diffusion magnetic resonance imaging (dMRI) data of 45 patients with Alzheimer's disease (AD) and 82 cognitively normal (CN) participants from the AD neuroimaging initiative database. The dMRI data were obtained with two b values (0 and 1000 s/mm2) from 27 institutions and three different 3-Tesla MRI scanners (two vendors). The ALPS index was calculated from multisite dMRI data, and COMBAT was used to harmonize the factors causing site variations. Welch's t test was used, Cohen's d was calculated to compare the difference in the ALPS index between AD and CN before and after harmonization, and Pearson's correlation coefficient was calculated to assess the relationships between the ALPS index and the cognitive score, [18F] fluorodeoxyglucose (FDG)-positron emission tomography (PET), and [18F] florbetapir (AV45)-PET standardized uptake value ratios (SUVRs). RESULTS: COMBAT harmonized scanner differences and increased Cohen's d of the left and right ALPS indexes between AD and CN from 0.288 to 0.438 and 0.328 to 0.480, respectively. The ALPS indexes were significantly different between AD and CN after harmonization (P < 0.05) but not before it. Moreover, Pearson's correlation coefficients between the ALPS index and cognitive score, FDG-PET, and AV45-PET SUVRs were higher after harmonization than before it. CONCLUSION: This study demonstrates the application of COMBAT harmonization to eliminate between-scanner, site, and protocol variations in the ALPS index calculated from DTI-ALPS using dMRI and possibly facilitate the use of the ALPS index in multi-center studies.

    DOI: 10.1007/s11604-023-01432-z

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  109. New trend in artificial intelligence-based assistive technology for thoracic imaging. Reviewed International journal

    Masahiro Yanagawa, Rintaro Ito, Taiki Nozaki, Tomoyuki Fujioka, Akira Yamada, Shohei Fujita, Koji Kamagata, Yasutaka Fushimi, Takahiro Tsuboyama, Yusuke Matsui, Fuminari Tatsugami, Mariko Kawamura, Daiju Ueda, Noriyuki Fujima, Takeshi Nakaura, Kenji Hirata, Shinji Naganawa

    La Radiologia medica   Vol. 128 ( 10 ) page: 1236 - 1249   2023.10

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    Although there is no solid agreement for artificial intelligence (AI), it refers to a computer system with intelligence similar to that of humans. Deep learning appeared in 2006, and more than 10 years have passed since the third AI boom was triggered by improvements in computing power, algorithm development, and the use of big data. In recent years, the application and development of AI technology in the medical field have intensified internationally. There is no doubt that AI will be used in clinical practice to assist in diagnostic imaging in the future. In qualitative diagnosis, it is desirable to develop an explainable AI that at least represents the basis of the diagnostic process. However, it must be kept in mind that AI is a physician-assistant system, and the final decision should be made by the physician while understanding the limitations of AI. The aim of this article is to review the application of AI technology in diagnostic imaging from PubMed database while particularly focusing on diagnostic imaging in thorax such as lesion detection and qualitative diagnosis in order to help radiologists and clinicians to become more familiar with AI in thorax.

    DOI: 10.1007/s11547-023-01691-w

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  110. MOGADのGlymphatic systemのDTI-ALPSを用いた解析 Reviewed

    宮地 真由, 富沢 雄二, 星野 泰延, コッス・ダビデ, 萩原 彰文, 鎌形 康司, 関根 永久, 高林 海斗, 田岡 俊昭, 仲谷 元, 横山 和正, 長縄 慎二, 青木 茂樹, 服部 信孝

    臨床神経学   Vol. 63 ( Suppl. ) page: S275 - S275   2023.9

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  111. A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents. Reviewed International journal

    Tadashi Shiohama, Norihide Maikusa, Masahiro Kawaguchi, Jun Natsume, Yoshiyuki Hirano, Keito Saito, Jun-Ichi Takanashi, Jacob Levman, Emi Takahashi, Koji Matsumoto, Hajime Yokota, Shinya Hattori, Keita Tsujimura, Daisuke Sawada, Tomoko Uchida, Tomozumi Takatani, Katsunori Fujii, Shinji Naganawa, Noriko Sato, Hiromichi Hamada

    Diagnostics (Basel, Switzerland)   Vol. 13 ( 17 )   2023.9

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    Regional anatomical structures of the brain are intimately connected to functions corresponding to specific regions and the temporospatial pattern of genetic expression and their functions from the fetal period to old age. Therefore, quantitative brain morphometry has often been employed in neuroscience investigations, while controlling for the scanner effect of the scanner is a critical issue for ensuring accuracy in brain morphometric studies of rare orphan diseases due to the lack of normal reference values available for multicenter studies. This study aimed to provide across-site normal reference values of global and regional brain volumes for each sex and age group in children and adolescents. We collected magnetic resonance imaging (MRI) examinations of 846 neurotypical participants aged 6.0-17.9 years (339 male and 507 female participants) from 5 institutions comprising healthy volunteers or neurotypical patients without neurological disorders, neuropsychological disorders, or epilepsy. Regional-based analysis using the CIVET 2.1.0. pipeline provided regional brain volumes, and the measurements were across-site combined using ComBat-GAM harmonization. The normal reference values of global and regional brain volumes and lateral indices in our study could be helpful for evaluating the characteristics of the brain morphology of each individual in a clinical setting and investigating the brain morphology of ultra-rare diseases.

    DOI: 10.3390/diagnostics13172774

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  112. Four-dimensional Flow MRI Assessment of Portal Hemodynamics and Hepatic Regeneration after Portal Vein Embolization. Reviewed International journal

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Ryota Horiguchi, Shoji Kawakatsu, Takashi Mizuno, Tomoki Ebata, Shinji Naganawa, Ning Jin, Yoshito Ichiba

    Radiology   Vol. 308 ( 3 ) page: e230709   2023.9

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    Background Percutaneous transhepatic portal vein (PV) embolization (PVE) is a standard preoperative procedure for advanced biliary cancer when the future liver remnant (FLR) is insufficient, yet the effect of this procedure on portal hemodynamics is still unclear. Purpose To assess whether four-dimensional (4D) MRI flowmetry can be used to estimate FLR volume and to identify the optimal time for this measurement. Materials and Methods This prospective single-center study enrolled consecutive adult patients with biliary cancer who underwent percutaneous transhepatic PVE for the right liver between June 2020 and November 2022. Portal hemodynamics were assessed using 4D flow MRI before PVE and within 1 day (0-day group) or 3-4 days (3-day group) after PVE. FLR volume was measured using CT before PVE and after PVE but before surgery. Blood flow changes were analyzed with the Wilcoxon signed rank test, and correlations with Spearman rank correlation. Results The 0-day group included 24 participants (median age, 72 years [IQR, 69-77 years]; 17 male participants), and the 3-day group included 13 participants (median age, 71 years [IQR, 68-78 years]; eight male participants). Both groups showed increased left PV (LPV) flow rate after PVE (0-day group: from median 3.72 mL/sec [IQR, 2.83-4.55 mL/sec] to 9.48 mL/sec [IQR, 8.12-10.7 mL/sec], P < .001; 3-day group: from median 3.65 mL/sec [IQR, 2.14-3.79 mL/sec] to 8.16 mL/sec [IQR, 6.82-8.98 mL/sec], P < .001). LPV flow change correlated with FLR volume change relative to the number of days from PVE to presurgery CT only in the 3-day group (ρ = 0.62, P = .02; 0-day group, P = .11). The output of the regression equation for estimating presurgery FLR volume correlated with CT-measured volume (ρ = 0.78; P = .002). Conclusion Four-dimensional flow MRI demonstrated increased blood flow in residual portal branches 3-4 days after PVE, offering insights for estimating presurgery FLR volume. Published under a CC BY 4.0 license. Supplemental material is available for this article. See also the editorial by Roldán-Alzate and Oechtering in this issue.

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  113. From pituitary adenoma to PitNET: it is time to discuss PitNET/pituitary adenoma. Reviewed

    Yasutaka Fushimi, Toshiaki Taoka, Shinji Naganawa

    Japanese journal of radiology   Vol. 41 ( 8 ) page: 787 - 788   2023.8

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    DOI: 10.1007/s11604-023-01412-3

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  114. Prognostic impact of EGFR/ALK alterations in leptomeningeal metastasis from lung adenocarcinoma treated with whole-brain radiotherapy. Reviewed International journal

    Hidekazu Oyoshi, Hidenari Hirata, Yasuhiro Hirano, Sadamoto Zenda, Yuzheng Zhou, Kento Tomizawa, Takeshi Fujisawa, Masaki Nakamura, Hidehiro Hojo, Atsushi Motegi, Shun-Ichiro Kageyama, Yoshitaka Zenke, Koichi Goto, Shunichi Ishihara, Shinji Naganawa, Tetsuo Akimoto

    Clinical & experimental metastasis   Vol. 40 ( 5 ) page: 407 - 413   2023.7

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    The prognosis and prognostic factors of patients receiving whole-brain radiotherapy (WBRT) for leptomeningeal metastasis (LM) from lung adenocarcinoma have not been established. Particularly, the impact of EGFR mutations and ALK rearrangements on survival remains unclear. This retrospective study evaluated the prognosis and prognostic factors of patients receiving WBRT for LM. We evaluated overall survival (OS) from WBRT initiation and clinical variables in 80 consecutive patients receiving WBRT for LM from lung adenocarcinoma at our institution between June 2013 and June 2021. After a median follow-up of 5.2 (range 0.5-56.5) months, the median OS was 6.2 months (95% CI 4.4-12.4). Of the 80 patients, 51 were classified as EGFR/ALK mutant (EGFR: 44; ALK: 6; both: 1) and 29 as wild-type. The median OS was 10.4 (95% CI 5.9-20.9) versus 3.8 (95% CI 2.5-7.7) months in the EGFR/ALK-mutant versus wild-type patients (HR = 0.49, P = 0.0063). Multivariate analysis indicated that EGFR/ALK alterations (HR = 0.54, P = 0.021) and Eastern Cooperative Oncology Group performance status (ECOG PS) of 0-1 (HR = 0.25, P < 0.001) were independent factors associated with favorable OS. Among the patients who underwent brain MRI before and after WBRT, intracranial progression-free survival was longer in the 26 EGFR/ALK-mutant than 13 wild-type patients (HR = 0.31, P = 0.0039). Although the prognosis of patients receiving WBRT for LM remains poor, EGFR/ALK alterations and good ECOG PS may positively impact OS in those eligible for WBRT.

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  115. Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer’s disease using 11C-Pittsburgh Compound-B Reviewed

    Tomohiro Tada, Kazuhiro Hara, Naotoshi Fujita, Yoshinori Ito, Hiroshi Yamaguchi, Reiko Ohdake, Kazuya Kawabata, Aya Ogura, Toshiyasu Kato, Takamasa Yokoi, Michihito Masuda, Shinji Abe, Shinichi Miyao, Shinji Naganawa, Masahisa Katsuno, Hirohisa Watanabe, Gen Sobue, Katsuhiko Kato

    Annals of Nuclear Medicine   Vol. 37 ( 7 ) page: 410 - 418   2023.7

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    Abstract

    Objectives

    Standardised uptake value ratio (SUVR) is usually obtained by dividing the SUV of the region of interest (ROI) by that of the cerebellar cortex. Cerebellar cortex is not a valid reference in cases where amyloid β deposition or lesions are present. Only few studies have evaluated the use of other regions as references. We compared the validity of the pons and corpus callosum as reference regions for the quantitative evaluation of brain positron emission tomography (PET) using <sup>11</sup>C-PiB compared to the cerebellar cortex.

    Methods

    We retrospectively evaluated data from 86 subjects with or without Alzheimer’s disease (AD). All subjects underwent magnetic resonance imaging, PET imaging, and cognitive function testing. For the quantitative analysis, three-dimensional ROIs were automatically placed, and SUV and SUVR were obtained. We compared these values between AD and healthy control (HC) groups.

    Results

    SUVR data obtained using the pons and corpus callosum as reference regions strongly correlated with that using the cerebellar cortex. The sensitivity and specificity were high when either the pons or corpus callosum was used as the reference region. However, the SUV values of the corpus callosum were different between AD and HC (p &lt; 0.01).

    Conclusions

    Our data suggest that the pons and corpus callosum might be valid reference regions.

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    Other Link: https://link.springer.com/article/10.1007/s12149-023-01843-y/fulltext.html

  116. 田岡俊昭先生の2023 ISMRM Senior Fellow 受章を記念して Reviewed

    長縄慎二

    日本磁気共鳴医学会雑誌   Vol. 43 ( 3 )   2023.7

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  117. Clinical applications of artificial intelligence in liver imaging Reviewed

    Akira Yamada, Koji Kamagata, Kenji Hirata, Rintaro Ito, Takeshi Nakaura, Daiju Ueda, Shohei Fujita, Yasutaka Fushimi, Noriyuki Fujima, Yusuke Matsui, Fuminari Tatsugami, Taiki Nozaki, Tomoyuki Fujioka, Masahiro Yanagawa, Takahiro Tsuboyama, Mariko Kawamura, Shinji Naganawa

    Radiologia Medica   Vol. 128 ( 6 ) page: 655 - 667   2023.6

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    This review outlines the current status and challenges of the clinical applications of artificial intelligence in liver imaging using computed tomography or magnetic resonance imaging based on a topic analysis of PubMed search results using latent Dirichlet allocation. LDA revealed that “segmentation,” “hepatocellular carcinoma and radiomics,” “metastasis,” "fibrosis," and "reconstruction" were current main topic keywords. Automatic liver segmentation technology using deep learning is beginning to assume new clinical significance as part of whole-body composition analysis. It has also been applied to the screening of large populations and the acquisition of training data for machine learning models and has resulted in the development of imaging biomarkers that have a significant impact on important clinical issues, such as the estimation of liver fibrosis, recurrence, and prognosis of malignant tumors. Deep learning reconstruction is expanding as a new technological clinical application of artificial intelligence and has shown results in reducing contrast and radiation doses. However, there is much missing evidence, such as external validation of machine learning models and the evaluation of the diagnostic performance of specific diseases using deep learning reconstruction, suggesting that the clinical application of these technologies is still in development.

    DOI: 10.1007/s11547-023-01638-1

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  118. Retrospective non-inferiority study of stereotactic radiosurgery for more than ten brain metastases Reviewed

    Naoya Nagai, Yutaro Koide, Yurika Shindo, Shingo Hashimoto, Hiroyuki Tachibana, Takeshi Kodaira, Shunichi Ishihara, Shinji Naganawa

    Journal of Neuro-Oncology   Vol. 163 ( 2 ) page: 385 - 395   2023.6

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    DOI: 10.1007/s11060-023-04358-8

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    Other Link: https://link.springer.com/article/10.1007/s11060-023-04358-8/fulltext.html

  119. もやもや病にGlymphatic system機能不全は存在するか? DTI-ALPS indexによる評価 Reviewed

    原 祥子, 菊田 潤子, 高林 海斗, 鎌形 康司, 林 志保里, 稲次 基希, 田中 洋次, 堀 正明, 石井 賢二, 成相 直, 田岡 俊昭, 長縄 慎二, 青木 茂樹, 前原 健寿

    日本磁気共鳴医学会雑誌   Vol. 43 ( 2 ) page: 56 - 59   2023.5

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    もやもや病のGlymphatic system(GS)について、DTI analysis along the perivascular space(DTI-ALPS index)を用いて検討した。成人もやもや病患者46名(男性13名、女性33名、平均38.4歳)と年齢、性別の合致した健常人34名(男性7名、女性27名、平均40.1歳)を対象とし、3T機でEPIシーケンスによる拡散MRIとMPRAGE法による3DT1強調像を撮影した。患者全例で認知機能検査としてTrail Making Test(TMT)を行った。もやもや病のDTI-ALPS indexは健常人より有意に低く、脳実質水成分と負の相関を示した。DTI-ALPS indexはPETのパラメータのうち、脳灌流圧の逆波である平均通過時間(MTT)と有意な負の相関を示した。遂行機能障害が強いほど点数が高くなるTMT-Bは左半球のDTI-ALPS indexと有意な負の相関を示した。もやもや病では脳循環不全の程度に応じてGS機能不全が存在し、脳実質の水成分増加を生じ、認知機能障害と関連する可能性があると考えられた。

  120. もやもや病にGlymphatic system機能不全は存在するか?―DTI-ALPS indexによる評価― Reviewed

    原 祥子、菊田潤子、高林海斗、鎌形康司、林 志保里、稲次基希、田中洋次、堀 正明、石井賢二、 成相 直、田岡俊昭、長縄慎二、青木茂樹、前原健寿

    日本磁気共鳴医学会雑誌   Vol. 43 ( 2 ) page: 56 - 59   2023.5

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  121. ALPS-indexを用いた糖尿病と糖尿病前期の病態におけるGlymphatic systemの評価 Reviewed

    Rukeye Tuerxun、鎌形康司、Christina Andica、 内田 航、斎藤勇哉、高林海斗、加賀 英義、染谷由希、 明石敏昭、和田昭彦、田端宏樹、内藤仁嗣、田村好史、田岡俊昭、長縄慎二、河盛隆造、綿田裕孝、青木茂樹

    日本磁気共鳴医学会雑誌   Vol. 43 ( 2 ) page: 60 - 62   2023.5

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  122. Labyrinthine calcification in ears with otitis media and antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV): A report of two cases. Reviewed International journal

    Tadao Yoshida, Masumi Kobayashi, Satofumi Sugimoto, Shinji Naganawa, Michihiko Sone

    Auris, nasus, larynx   Vol. 50 ( 2 ) page: 299 - 304   2023.4

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    Otitis media with antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV) has been proposed as a new type of otitis media. The hearing loss caused by OMAAV can be expected to improve with early detection and intervention, but if it continues to worsen and leads to deafness, it is challenging to recover the patient's hearing. When bilateral deafness occurs, cochlear implant (CI) surgery is the only way to improve hearing. Here, Case 1 showed unilateral cochlear calcification, and Case 2 showed bilateral cochlear calcification. In Case 1, CI surgery was performed on the ear lacking calcification, and in Case 2 it was performed on the ear with milder calcification. In Case 2, granulation was present from the tympanic space to the mastoid, the round window was closed, and the basal turn of the cochlea was narrowed. Such calcification of the cochlea caused by OMAAV has not been reported so far. It is essential to detect these changes by computed tomography scans at an early stage and to perform CI surgery at an appropriate time, because hearing improvements are not expected in patients who become deaf because of OMAAV.

    DOI: 10.1016/j.anl.2022.01.004

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  123. Postendovascular Aneurysmal Repair Increase in Local Energy Loss for Fusiform Abdominal Aortic Aneurysm: Assessments With 4D flow MRI. Reviewed International journal

    Ryota Horiguchi, Yasuo Takehara, Masataka Sugiyama, Ryota Hyodo, Tomohiro Komada, Masaya Matsushima, Shinji Naganawa, Takashi Mizuno, Yasuo Sakurai, Masayuki Sugimoto, Hiroshi Banno, Kimihiro Komori, Keiichi Itatani

    Journal of magnetic resonance imaging : JMRI   Vol. 57 ( 4 ) page: 1199 - 1211   2023.4

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    BACKGROUND: Although endovascular aneurysmal repair (EVAR) is a preferred treatment for abdominal aortic aneurysm (AAA) owing to its low invasiveness, its impact on the local hemodynamics has not been fully assessed. PURPOSE: To elucidate how EVAR affects the local hemodynamics in terms of energy loss (EL). STUDY TYPE: Prospective single-arm study. FIELD STRENGTH/SEQUENCE: A 3.0 T/4D flow MRI using a phase-contrast three-dimensional cine-gradient-echo sequence. POPULATION: A total of 13 consecutive patients (median [interquartile range] age: 77.0 [73.0, 78.8] years, 11 male) scheduled for EVAR as an initial treatment for fusiform AAA. ASSESSMENT: 4D flow MRI covering the abdominal aorta and bilateral common iliac arteries and the corresponding stent-graft (SG) lumen was performed before and after EVAR. Plasma brain natriuretic peptide (BNP) was measured within 1 week before and 1 month after EVAR. The hemodynamic data, including mean velocity and the local EL, were compared pre-/post-EVAR. EL was correlated with AAA neck angle and with BNP. Patients were subdivided into deformed (N = 5) and undeformed SG subgroups (N = 8) and pre-/post-EVAR BNP compared in each. STATISTICS: Parametric or nonparametric methods. Spearman's rank correlation coefficients (r). The interobserver/intraobserver variabilities with Bland-Altman plots. A P value < 0.05 is considered significant. RESULTS: The mean velocity (cm/sec) at the AAA was five times greater after EVAR: 4.79 ± 0.32 vs. 0.91 ± 0.02. The total EL (mW) increased by 1.7 times after EVAR: 0.487 (0.420, 0.706) vs. 0.292 (0.192, 0.420). The total EL was proportional to the AAA neck angle pre-EVAR (r = 0.691) and post-EVAR (r = 0.718). BNP (pg/mL) was proportional to the total EL post-EVAR (r = 0.773). In the deformed SG group, EL (0.349 [0.261, 0.416]) increased 2.4-fold to 0.848 (0.597, 1.13), and the BNP 90.3 (53.6, 105) to 100 (67.2, 123) post-EVAR. CONCLUSION: The local EL showed a 1.7-fold increase after EVAR. The larger increase in the EL in the deformed SG group might be a potential concern for frail patients. EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 2.

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  124. 門松健治先生のすごさ;高いVision、現実解実現のための行動力 Invited Reviewed

    長縄慎二

    門松健治教授退任記念誌     page: 75 - 76   2023.4

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  125. 門松健治先生のすごさ;高いVision、現実解実現のための行動力 Invited Reviewed

    長縄慎二

    門松健治教授退任記念誌     page: 75 - 76   2023.4

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  126. Glymphatic system impairment in nonathlete older male adults who played contact sports in their youth associated with cognitive decline: A diffusion tensor image analysis along the perivascular space study Reviewed International journal

    Yuichi Morita, Koji Kamagata, Christina Andica, Kaito Takabayashi, Junko Kikuta, Shohei Fujita, Thomas Samoyeau, Wataru Uchida, Yuya Saito, Hiroki Tabata, Hitoshi Naito, Yuki Someya, Hideyoshi Kaga, Yoshifumi Tamura, Mari Miyata, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Hirotaka Watada, Ryuzo Kawamori, Osamu Abe, Shigeki Aoki

    Frontiers in Neurology   Vol. 14   page: 1100736 - 1100736   2023.2

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    Background and purpose

    Exposure to contact sports in youth causes brain health problems later in life. For instance, the repetitive head impacts in contact sports might contribute to glymphatic clearance impairment and cognitive decline. This study aimed to assess the effect of contact sports participation in youth on glymphatic function in old age and the relationship between glymphatic function and cognitive status using the analysis along the perivascular space (ALPS) index.

    Materials and methods

    A total of 52 Japanese older male subjects were included in the study, including 12 who played heavy-contact sports (mean age, 71.2 years), 15 who played semicontact sports (mean age, 73.1 years), and 25 who played noncontact sports (mean age, 71.3 years) in their youth. All brain diffusion-weighted images (DWIs) of the subjects were acquired using a 3T MRI scanner. The ALPS indices were calculated using a validated semiautomated pipeline. The ALPS indices from the left and right hemispheres were compared between groups using a general linear model, including age and years of education. Furthermore, partial Spearman's rank correlation tests were performed to assess the correlation between the ALPS indices and cognitive scores (Mini-Mental State Examination and the Japanese version of the Montreal Cognitive Assessment [MoCA-J]) after adjusting for age years of education and HbA1c.

    Results

    The left ALPS index was significantly lower in the heavy-contact and semicontact groups than that in the noncontact group. Although no significant differences were observed in the left ALPS index between the heavy-contact and semicontact groups and in the right ALPS index among groups, a trend toward lower was found in the right ALPS index in individuals with semicontact and heavy-contact compared to the noncontact group. Both sides' ALPS indices were significantly positively correlated with the MoCA-J scores.

    Conclusion

    The findings indicated the potential adverse effect of contact sports experience in youth on the glymphatic system function in old age associated with cognitive decline.

    DOI: 10.3389/fneur.2023.1100736

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  127. Neuroimaging findings related to glymphatic system alterations in older adults with metabolic syndrome. Reviewed International journal

    Christina Andica, Koji Kamagata, Kaito Takabayashi, Junko Kikuta, Hideyoshi Kaga, Yuki Someya, Yoshifumi Tamura, Ryuzo Kawamori, Hirotaka Watada, Toshiaki Taoka, Shinji Naganawa, Shigeki Aoki

    Neurobiology of disease   Vol. 177   page: 105990 - 105990   2023.2

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    OBJECTIVE: The glymphatic system is a glial-based perivascular network that promotes brain metabolic waste clearance. Reduced glymphatic flow has been observed in rat models of type 2 diabetes and hypertension, indicating the role of vascular risk factors in the glymphatic system. However, little is known about how vascular risk factors affect the human glymphatic system. The present study aims to assess the relationships between metabolic syndrome (MetS), a cluster of vascular risk factors, and the glymphatic system function using diffusion magnetic resonance imaging (MRI)-based measures of water diffusivity in the glymphatic compartments, including the brain interstitial space and perivascular spaces around the deep medullary vein. We hypothesized that vascular risk factors are associated with glymphatic dysfunction, leading to cognitive impairment in older adults. METHODS: This cross-sectional study assessed 61 older adults (age range, 65-82 years) who had participated in the Bunkyo Health Study, including 15 healthy controls (mean age, 70.87 ± 4.90 years) and 46 individuals with MetS (mean age, 71.76 ± 4.61 years). Fractional volume of extracellular-free water (FW) and an index of diffusion tensor imaging along the perivascular space (DTI-ALPS) were used as indirect indicators of water diffusivity in the interstitial extracellular and perivenous spaces of white matter, respectively. RESULTS: After adjusting for age, sex, years of education, total Fazekas scale, Pittsburgh sleep quality index (PSQI) score, and intracranial volume (ICV), a significantly (P = 0.030; Cohen's d = 1.01) higher FW was observed in individuals with MetS than in the healthy controls. Furthermore, individuals with MetS had a significantly (P = 0.031; Cohen's d = 0.86) lower ALPS index than the healthy controls, with age, sex, years of education, total Fazekas scale, PSQI score, ICV, fractional anisotropy, and mean diffusivity included as confounding factors. Higher FW was significantly associated with lower ALPS index (r = -0.37; P = 0.004). Multiple linear regression (MLR) with backward elimination analyses showed that higher diastolic blood pressure (BP; standardized β = 0.33, P = 0.005) was independently associated with higher FW, whereas higher fasting plasma glucose levels (standardized β = -0.63, P = 0.002) or higher Brinkman index of cigarette consumption cumulative amount (standardized β = -0.27, P = 0.022) were associated with lower ALPS index. The lower ALPS index (standardized β, 0.28; P = 0.040) was associated with poorer global cognitive performance, which was determined using the Japanese version of the Montreal Cognitive Assessment (MOCA-J) scores. Finally, partial correlation analyses showed a significant correlation between higher FW and lower MOCA-J scores (r = -0.35; P = 0.025) and between higher FW and higher diastolic BP (r = 0.32, P = 0.044). CONCLUSION: The present study shows the changes in diffusion MRI-based measures reflected by the higher FW and lower ALPS index in older adults with MetS, possibly due to the adverse effect of vascular risk factors on the glymphatic system. Our findings also indicate the associations between the diffusion MRI-based measures and elevated diastolic BP, hyperglycemia, smoking habit, and poorer cognitive performance. However, owing to the limitations of this study, the results should be cautiously interpreted.

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  128. 自己免疫性膵炎の画像診断:コンピュータ断層撮影と磁気共鳴画像法 Reviewed

    小川 浩、竹原康雄、長縄慎二

    Jpn. J Med Ultrasonics.   Vol. 50 ( 1 ) page: 39 - 45   2023.1

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  129. A plea for systematic literature analysis and conclusive study design, comment on: "Systematic review of magnetic resonance imaging for diagnosis of Meniere disease". Reviewed International journal

    Robert Gürkov, Krisztina Barath, Bert de Foer, Munehisa Fukushima, Michael Gluth, Jermy Hornibrook, Nicolas Perez-Fernandez, Ilmari Pyykkö, Michihiko Sone, Shin-Ichi Usami, Wuqing Wang, Jing Zou, Shinji Naganawa

    Journal of vestibular research : equilibrium & orientation   Vol. 33 ( 2 ) page: 151 - 157   2023

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    DOI: 10.3233/VES-190662

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  130. "Speckled Enhancement" on Gd-EOB-DTPA Enhanced MR Imaging of Primary Hepatic Mucosa-associated Lymphoid Tissue Lymphoma. Reviewed

    Ryota Hyodo, Yasuo Takehara, Ayumi Nishida, Masaya Matsushima, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 22 ( 3 ) page: 273 - 281   2023

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    PURPOSE: To elucidate MRI features of primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma, particularly, the "speckled enhancement" on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI. METHODS: The institutional review board approved this retrospective observational study and waived informed consent. Using our picture archiving and communication systems and electronic medical records, five patients histopathologically diagnosed as hepatic MALT lymphoma and clinically confirmed as primary lesions who had undergone dynamic contrast-enhanced (DCE)-CT and DCE-MRI with Gd-EOB-DTPA were identified from September 2009 to December 2020. Two radiologists assessed their CT and MRI data in consensus with a pathologist's advice. RESULTS: Overall, five lesions in five patients were included in this study. Precontrast CT showed hypoattenuation in all lesions. In the arterial phase of DCE-CT, four lesions (80%) showed hyperattenuation, whereas all lesions showed iso- to hypoattenuation in the delayed phase. A vessel penetration sign was also observed in all lesions. On MRI, all lesions showed hypointensity on T1-weighted images, hyperintensity on T2-weighted images, and restricted diffusion on diffusion-weighted images. Both DCE-CT and DCE-MRI with Gd-EOB-DTPA showed similar enhancement patterns, except for the hepatocyte phase. Notably, however, four out of five lesions showed characteristic "speckled enhancement" that refers to punctate positive enhancements within the low signal lesions on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI pathologically confirmed to be hepatocyte clusters that remained in the tumor. CONCLUSION: Primary hepatic MALT lymphomas were characterized by arterial phase enhancement, restricted diffusion, vessel penetration sign, and more specifically "speckled enhancement" in the hepatobiliary phase of DCE-MRI with Gd-EOB-DTPA.

    DOI: 10.2463/mrms.mp.2021-0069

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  131. Peripheral Retinal Leakage after Intravenous Administration of a Gadolinium-based Contrast Agent: Age Dependence, Temporal and Inferior Predominance and Potential Implications for Eye Homeostasis. Reviewed

    Shinji Naganawa, Rintaro Ito, Mariko Kawamura, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 22 ( 1 ) page: 45 - 55   2023

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    PURPOSE: Peripheral retinal leakage (PRL) of contrast medium from the ora serrata (i.e., the peripheral part of the retina) was recently reported in normal eyes using ultra-widefield fluorescein angiography. We occasionally see PRL of gadolinium-based contrast agents (GBCAs) in the vitreous from the temporal and inferior sides of the ora serrata on MR images of subjects without ophthalmic disease. In this study, we retrospectively evaluated these MR images to determine if PRL was associated with aging. We also evaluated whether the initial leakage appeared in the temporal and inferior sides, and whether there was uniform distribution within the vitreous after 24 hours. METHODS: In 127 subjects (9 volunteers, 85 patients with sudden deafness, and 33 patients with a suspicion of endolymphatic hydrops), pre- and post-contrast-enhanced heavily T2-weighted 3D-fluid attenuated inversion recovery (FLAIR) images were obtained. The presence or absence of PRL was subjectively evaluated. For patients with a suspicion of endolymphatic hydrops, 3D-real inversion recovery (IR) images were also obtained at pre-, 10 mins, 4 hours, and 24 hours after intravenous administration (IV) of GBCA. Four circular ROIs were placed in the vitreous humor and the signal intensity was measured. RESULTS: In the cases with PRL (n = 88) and without PRL (n = 47), the median age was 59 and 47 years, respectively (P = 0.001). At 4 hours after IV-GBCA, the mean signal increase in the inferior temporal ROI was greater than all the other ROIs. At 24 hours after IV-GBCA, no significant difference in signal intensity was observed for the four ROIs. CONCLUSION: PRL of GBCA is age-dependent and occurs mainly from the inferior temporal side of the ora serrata. The contrast effect was uniformly distributed at 24 hours after IV-GBCA. Future observations in a variety of diseases will determine the clinical significance of these findings.

    DOI: 10.2463/mrms.mp.2021-0100

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  132. Pitfalls of Using T2-contrast Enhancement Techniques in 3D-FLAIR to Detect Endolymphatic Hydrops. Reviewed

    Yutaka Kato, Shinji Naganawa, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 22 ( 3 ) page: 335 - 344   2023

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    PURPOSE: To determine whether T2-contrast enhancement techniques can be used to diagnose endolymphatic hydrops, we compared fluid signal artifacts with and without T2-contrast enhancement techniques in 3D fluid-attenuated inversion recovery (3D-FLAIR). METHODS: We prepared a custom-made phantom consisting of eight tubes half-filled with saline. Images were obtained using four 3D-FLAIR: without T2-contrast enhancement (Normal), with non-selective T2-inversion recovery (T2-IR), and two with non-selective T2 preparation IR (T2-prep). Scans were performed with and without rice covering the phantom to simulate minimal and severe B0-inhomogeneity conditions. The average signal intensity (SI) values of eight saline tubes were compared between the four sequences and between each other. Comparisons were performed for all measurement slices and the central 10 slices. The images using T2-contrast enhancement technique were obtained from a volunteer and a patient suspected of Meniere's disease. RESULTS: The Normal sequence SI for all slices was significantly lower than that for the other sequences, with smaller standard deviation (SD) and no outliers. Several outliers were detected in the other sequences. The SDs and outliers were larger without rice than with rice. When the central 10 slices with rice, the T2-IR had a significantly higher SI with more outliers compared with the Normal sequence. The T2-prep had no outliers and SIs that were comparable to those of the Normal sequence. However, without rice, the T2-IR and T2-prep sequences had significantly higher SIs with outliers and larger SDs compared to the Normal sequence. In the corresponding images, the Normal sequence achieved excellent fluid suppression, whereas the T2-IR and T2-prep sequences showed high-signal artifacts. Imperfect fluid suppressions were observed in the volunteer image and the endolymphatic hydrops on the post-gadolinium image differed in size and shape in the non-injected T2-IR in the patient image. CONCLUSION: T2-contrast enhancement techniques should be used with caution in 3D-FLAIR for diagnosing endolymphatic hydrops.

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  133. Assessing the Complicated Venous Hemodynamics and Therapeutic Outcomes of Budd-Chiari Syndrome with Respiratory-gated 4D Flow MR Imaging During the Expiratory and Inspiratory Phases. Reviewed

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Shinya Yokoyama, Yoji Ishizu, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 22 ( 1 ) page: 1 - 6   2023

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    A man in his 50s with Budd-Chiari syndrome diagnosed with the suprahepatic inferior vena cava (IVC) obstruction on CT was assessed using 4D Flow MRI before and after balloon angioplasty. 4D Flow MRI acquired in two respiratory phases, depicted complex hemodynamic and respiratory variability, and a jet stream at the narrowed channel of the membranous IVC. Post-interventional 4D Flow MRI showed that the IVC blood flow increased with corrected flow directions in the infrarenal IVC.

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  134. Parasagittal Cystic Lesions May Arise from the Pial Sheath around the Cortical Venous Wall. Reviewed

    Shinji Naganawa, Rintaro Ito, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 22 ( 1 ) page: 143 - 146   2023

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    It has been reported that perivenous cystic structures near the parasagittal dura are associated with the leakage of gadolinium-based contrast agents at 4 hours after intravenous administration. The origin of such cystic structures remains unknown. While reading many cases of MR cisternography, we noticed that some of the cystic structures appeared to connect to the perivenous subpial space. This new imaging finding might facilitate future research of the waste clearance system for the central nervous system.

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  135. Current State of Artificial Intelligence in Clinical Applications for Head and Neck MR Imaging Reviewed

    Noriyuki Fujima, Koji Kamagata, Daiju Ueda, Shohei Fujita, Yasutaka Fushimi, Masahiro Yanagawa, Rintaro Ito, Takahiro Tsuboyama, Mariko Kawamura, Takeshi Nakaura, Akira Yamada, Taiki Nozaki, Tomoyuki Fujioka, Yusuke Matsui, Kenji Hirata, Fuminari Tatsugami, Shinji Naganawa

    Magnetic Resonance in Medical Sciences   Vol. 22 ( 4 ) page: 401 - 414   2023

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    DOI: 10.2463/mrms.rev.2023-0047

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  136. Stereotactic radiotherapy for ventricular tachycardia: A study protocol. Reviewed International journal

    Mariko Kawamura, Masafumi Shimojo, Yasuya Inden, Takeshi Kamomae, Kuniyasu Okudaira, Tomohiro Komada, Sumire Aoki, Yurika Shindo, Ryotaro Yasui, Yusuke Yanagi, Masayuki Okumura, Takehiro Yamada, Yuka Kozai, Yumi Oie, Yutaka Kato, Shunichi Ishihara, Toyoaki Murohara, Shinji Naganawa

    F1000Research   Vol. 12   page: 798 - 798   2023

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    BACKGROUND: Currently, the standard curative treatment for ventricular tachycardia (VT) and ventricular fibrillation (VF) is radiofrequency catheter ablation. However, when the VT circuit is deep in the myocardium, the catheter may not be delivered, and a new, minimally invasive treatment using different energies is desired. METHODS: This is a protocol paper for a feasibility study designed to provide stereotactic radiotherapy for refractory VT not cured by catheter ablation after at least one catheter ablation. The primary end point is to evaluate the short-term safety of this treatment and the secondary endpoint is to evaluate its efficacy as assessed by the reduction in VT episode. Cyberknife M6 radiosurgery system will be used for treatment, and the prescribed dose to the target will be 25Gy in one fraction. The study will be conducted on three patients. CONCLUSION: Since catheter ablation is the only treatment option for VT that is covered by insurance in Japan, there is currently no other treatment for VT/VF that cannot be cured by catheter ablation. We hope that this feasibility study will provide hope for patients who are currently under the stress of ICD activation. TRIAL REGISTRATION: The study has been registered in the Japan Registry of Clinical Trials (jRCTs042230030).

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  137. Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease. Reviewed International journal

    Koji Kamagata, Christina Andica, Kaito Takabayashi, Yuya Saito, Toshiaki Taoka, Hayato Nozaki, Junko Kikuta, Shohei Fujita, Akifumi Hagiwara, Kouhei Kamiya, Akihiko Wada, Toshiaki Akashi, Katsuhiro Sano, Mitsuo Nishizawa, Masaaki Hori, Shinji Naganawa, Shigeki Aoki

    Neurology   Vol. 99 ( 24 ) page: E2648 - E2660   2022.12

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    BACKGROUND AND OBJECTIVES: The glymphatic system is a whole-brain perivascular network, which promotes CSF/interstitial fluid exchange. Alterations to this system may play a pivotal role in amyloid β (Aβ) accumulation. However, its involvement in Alzheimer's disease (AD) pathogenesis is not fully understood. Here, we investigated the changes in noninvasive MRI measurements related to the perivascular network in patients with mild cognitive impairment (MCI) and AD. Additionally, we explored the associations of MRI measures with neuropsychological score, PET standardized uptake value ratio (SUVR), and Aβ deposition. METHODS: MRI measures, including perivascular space (PVS) volume fraction (PVSVF), fractional volume of free water in white matter (FW-WM), and index of diffusivity along the perivascular space (ALPS index) of patients with MCI, those with AD, and healthy controls from the Alzheimer's Disease Neuroimaging Initiative database were compared. MRI measures were also correlated with the levels of CSF biomarkers, PET SUVR, and cognitive score in the combined subcohort of patients with MCI and AD. Statistical analyses were performed with age, sex, years of education, and APOE status as confounding factors. RESULTS: In total, 36 patients with AD, 44 patients with MCI, and 31 healthy controls were analyzed. Patients with AD had significantly higher total, WM, and basal ganglia PVSVF (Cohen's d = 1.15-1.48; p < 0.001), and FW-WM (Cohen's d = 0.73; p < 0.05) and a lower ALPS index (Cohen's d = 0.63; p < 0.05) than healthy controls. Meanwhile, the MCI group only showed significantly higher total (Cohen's d = 0.99; p < 0.05) and WM (Cohen's d = 0.91; p < 0.05) PVSVF. Low ALPS index was associated with lower CSF Aβ42 (r s = 0.41, p fdr = 0.026), FDG-PET uptake (r s = 0.54, p fdr < 0.001), and worse multiple cognitive domain deficits. High FW-WM was also associated with lower CSF Aβ42 (r s = -0.47, p fdr = 0.021) and worse cognitive performances. CONCLUSION: Our study indicates that changes in PVS-related MRI parameters occur in MCI and AD, possibly due to impairment of the glymphatic system. We also report the associations between MRI parameters and Aβ deposition, neuronal change, and cognitive impairment in AD.

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  138. Reproducibility of functional connectivity metrics estimated from resting-state functional MRI with differences in days, coils, and global signal regression Reviewed

    Sanae Kato, Epifanio Bagarinao, Haruo Isoda, Shuji Koyama, Hirohisa Watanabe, Satoshi Maesawa, Kazuhiro Hara, Masahisa Katsuno, Shinji Naganawa, Norio Ozaki, Gen Sobue

    Radiological Physics and Technology   Vol. 15 ( 4 ) page: 298 - 310   2022.12

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    Other Link: https://link.springer.com/article/10.1007/s12194-022-00670-6/fulltext.html

  139. 17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function. Reviewed International journal

    Tadao Yoshida, Shinji Naganawa, Masumi Kobayashi, Satofumi Sugimoto, Naomi Katayama, Tsutomu Nakashima, Yutaka Kato, Kazushige Ichikawa, Hiroshi Yamaguchi, Kazuki Nishida, Michihiko Sone

    Frontiers in neurology   Vol. 13   page: 1016577 - 1016577   2022.11

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    We evaluated the inner ear distribution of 17O-labeled saline administered to the human tympanic cavity. Magnetic resonance imaging was performed after intratympanic administration in five healthy volunteers and one patient with cochlear endolymphatic hydrops. In all volunteers, 17O-labeled water permeated the cochlear basal turn and vestibule at 30 min and disappeared gradually within 2-4 h. All participants experienced positional vertigo lasting a few hours to a few days. Visualization of 17O-labeled water distribution in the endolymphatic space of the posterior ampulla showed indistinct separation of endolymph and perilymph in the cochlea and most of the vestibule in all participants. Intralabyrinthine distribution of 17O-labeled water differed from that in previous reports of intratympanically administered gadolinium-based contrast agent. 17O-labeled water in the endolymphatic space may cause heavier endolymph and positional vertigo. These results of this study may add new insights for investigating the distribution and the effects of molecules in the inner ear after the intratympanic administration in living humans.

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  140. 4D Flow MRI in the portal venous system: imaging and analysis methods, and clinical applications. Reviewed International journal

    Ryota Hyodo, Yasuo Takehara, Shinji Naganawa

    La Radiologia medica   Vol. 127 ( 11 ) page: 1181 - 1198   2022.11

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    Thus far, ultrasound, CT, and 2D cine phase-contrast MRI has been adopted to evaluate blood flow and vascular morphology in the portal venous system; however, all these techniques have some shortcomings, such as limited field of view and difficulty in accurately evaluating blood flow. A new imaging technique, namely 3D cine phase-contrast (4D Flow) MRI, can acquire blood flow data of the entire abdomen at once and in a time-resolved manner, allowing visual, quantitative, and comprehensive assessment of blood flow in the portal venous system. In addition, a retrospective blood flow analysis, i.e., "retrospective flowmetry," is possible. Although the development of 4D Flow MRI for the portal system has been delayed compared to that for the arterial system owing to the lower flow velocity of the portal venous system and the presence of respiratory artifacts, several useful reports have recently been published as the technology has advanced. In the first part of this narrative review article, technical considerations of image acquisition and analysis methods of 4D Flow MRI for the portal venous system and the validations of their results are described. In the second part, the current clinical application of 4D Flow MRI for the portal venous system is reviewed.

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  141. Iodinated Contrast Media Substitution to Prevent Recurrent Hypersensitivity Reactions: A Systematic Review and Meta-Analysis. Reviewed International journal

    Hiroyasu Umakoshi, Takashi Nihashi, Akira Takada, Naoki Hirasawa, Shunichi Ishihara, Yasuo Takehara, Shinji Naganawa, Matthew S Davenport, Teruhiko Terasawa

    Radiology   Vol. 305 ( 2 ) page: 341 - 349   2022.11

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    Background Changing iodinated contrast media (ICM) may reduce the risk of recurrent ICM-induced hypersensitivity reactions in patients with a prior reaction. Purpose To perform a systematic review on the effectiveness of ICM change in comparison with no change to prevent recurrent ICM immediate hypersensitivity reactions. Materials and methods Multiple data bases were searched without language restriction between January 1990 and August 2021 to identify comparative studies of any design that included patients with a prior ICM hypersensitivity reaction to low-osmolality ICM and re-exposure to intravascular ICM. The methods used included a duplicate assessment of eligibility, double extraction of quantitative data, validity assessment, and random-effects meta-analysis. The primary outcome was the incidence of all-grade immediate recurrent hypersensitivity reactions. Secondary outcomes were the incidence of severe immediate recurrent hypersensitivity reactions and other adverse events associated with ICM change. Results Six retrospective observational studies at moderate to severe risk of bias assessed 7155 adult patients (4329 in the ICM change group and 2826 in the no-change group). Studies adopted nonstandardized switching methods, and the proportions of the ICM change group ranged between 19% (five of 27 examinations) and 80% (3104 of 3880 examinations). A Bayesian meta-analysis revealed that changing ICM was associated with a reduced risk of recurrent hypersensitivity reaction by 61% (risk ratio = 0.39; 95% credible interval [CrI]: 0.24, 0.58). The wide-ranging estimates of risk reduction were not explained by the risk of bias ratings, the event rates in the no-change group, the index-reaction severity, or the co-administered nonstandard premedication. Rare severe recurrent reactions (five studies with five events) precluded a conclusion (risk ratio = 0.34, favoring ICM change; CrI: 0.01, 3.74). Adverse events associated with ICM change were not reported. Conclusion In observational evidence of limited quality, iodinated contrast media (ICM)-change was associated with a reduced risk of recurrent immediate hypersensitivity reaction in patients with a prior ICM-induced hypersensitivity reaction. © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by McDonald in this issue.

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  142. Impact of tissue properties on time-dependent alterations in apparent diffusion coefficient: A phantom study using oscillating gradient spin-echo and pulsed gradient spin-echo sequences Reviewed

    Kazushige Ichikawa, Toshiaki Taoka, Masanori Ozaki, Mayuko Sakai, Hiroshi Yamaguchi, Shinji Naganawa

    Japanese Journal of Radiology   Vol. 40 ( 9 ) page: 970 - 978   2022.9

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    PURPOSE: The purpose of this study was to investigate whether the changes in apparent diffusion coefficients (ADCs) due to differences in diffusion time reflect tissue properties in actual measurements of phantoms. MATERIALS AND METHODS: Various n-alkane phantoms and sucrose/collagen phantoms with various collagen densities were set up with and without polyvinyl alcohol (PVA) foam with an average pore diameter of 300 μm. Thus, n-alkanes or sucrose/collagen represented substrate viscosity and the presence of PVA foam represented tissue structure with septum. Diffusion-weighted images with various diffusion times (7.71-60 ms) were acquired using pulsed-gradient spin-echo (PGSE) and oscillating-gradient spin-echo (OGSE) sequences. The ADCs of the phantoms with and without PVA foam were calculated. RESULTS: The ADCs of some of the phantoms without PVA decreased with diffusion times decreased. In the n-alkane phantoms, only C8H18 showed significantly different ADCs depending on the use of PVA foam in the OGSE sequence. On the other hand, sucrose/collagen phantoms showed significant differences according to diffusion time. The ADCs of the phantoms decreased as the molecular size of the n-alkanes or collagen density of the sucrose/collagen phantom increased. Compared to phantoms without PVA foam, the ADC of the phantoms with PVA foam decreased as the diffusion time increased. CONCLUSION: Changes in ADCs due to differences in diffusion time reflect tissue properties in actual measurements of phantoms. These changes in ADCs can be used for tissue characterization in vivo.

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  143. Diffusion-weighted image analysis along the perivascular space (DWI-ALPS) for evaluating interstitial fluid status: age dependence in normal subjects. Reviewed

    Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Toshiki Nakane, Mayuko Sakai, Kazushige Ichikawa, Hisashi Kawai, Shinji Naganawa

    Japanese journal of radiology   Vol. 40 ( 9 ) page: 894 - 902   2022.9

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    PURPOSE: The purpose of this study was to evaluate the interstitial fluid status in a wide range of age groups using diffusion-weighted image analysis along the perivascular space (DWI-ALPS) method, which is a simplified variation of diffusion tensor image analysis along the perivascular space (DTI-ALPS). MATERIALS AND METHODS: This retrospective study included data from 128 patients who underwent clinical magnetic resonance imaging (MRI) studies, including DWI, and were found to have no abnormal findings in the brain on MRI. Three motion-probing gradients of the DWI were applied in an orthogonal direction to the imaging plane. Apparent diffusion coefficient images in the x-, y-, and z-axes were retrospectively generated, and composite color images were created to locate the projection and association fiber area on the slice including the body of the lateral ventricle. ALPS indices were calculated, and correlations with age were evaluated using linear and second-degree regression analysis. Linear regression analysis was also performed for a subgroup of patients older than 40 years. In addition, an analysis of variance (ANOVA) test among the generations was performed. RESULTS: The linear regression analysis between age and the ALPS index showed a correlation coefficient of -0.20 for all age group and -0.51 for the subgroup older than 40 years. The second-degree regression analysis showed a correlation coefficient of 0.39. ANOVA showed that the 40's generation showed a statistically significant higher value of ALPS index compared to all other generations except for the 30's generation. While, the 70's generation showed a statistically significant lower value of the ALPS index compared to all other generations. CONCLUSIONS: The analysis of the DWI-APLS method showed a correlation between age and the ALPS index in second-degree distribution which peaked in the 40's generation. This finding in normal subjects may be fundamental in the analysis of disease cases. We tried to evaluate the glymphatic system status in a wide range of age groups using diffusion-weighted image analysis along the perivascular space (DWI-ALPS) method, and the results showed a correlation between age and the ALPS index in second-degree distribution which peaked in the 40's generation.

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  144. 人工知能を応用したバーチャル3D thin-section CTを用いた肺腺癌の充実成分径の計測 Reviewed

    岩野 信吾, 神谷 晋一朗, 伊藤 倫太郎, 工藤 彰, 北村 嘉郎, 中村 圭児, 長縄 慎二

    断層映像研究会雑誌   Vol. 49 ( 2 ) page: 39 - 39   2022.9

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  145. Development of a high-resolution two-dimensional detector-based dose verification system for tumor-tracking irradiation in the CyberKnife system. Reviewed International journal

    Fumitaka Kawabata, Takeshi Kamomae, Kuniyasu Okudaira, Masataka Komori, Hiroshi Oguchi, Motoharu Sasaki, Masaki Mori, Mariko Kawamura, Shinji Abe, Shunichi Ishihara, Shinji Naganawa

    Journal of applied clinical medical physics   Vol. 23 ( 8 ) page: e13645 - e13645   2022.8

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    We aim to evaluate the basic characteristics of SRS MapCHECK (SRSMC) for CyberKnife (CK) and establish a dose verification system using SRSMC for the tumor-tracking irradiation for CK. The field size and angular dependence of SRSMC were evaluated for basic characterization. The output factors (OPFs) and absolute doses measured by SRSMC were compared with those measured using microDiamond and microchamber detectors and those calculated by the treatment planning system (TPS). The angular dependence was evaluated by comparing the SRSMC with a microchamber. The tumor-tracking dose verification system consists of SRSMC and a moving platform. The doses measured using SRSMC were compared with the doses measured using a microchamber and radiochromic film. The OPFs and absolute doses of SRSMC were within ±3.0% error for almost all field sizes, and the angular dependence was within ±2.0% for all incidence angles. The absolute dose errors between SRSMC and TPS tended to increase when the field size was smaller than 10 mm. The absolute doses of the tumor-tracking irradiation measured using SRSMC and those measured using a microchamber agreed within 1.0%, and the gamma pass rates of SRSMC in comparison with those of the radiochromic film were greater than 95%. The basic characteristics of SRSMC for CK presented acceptable results for clinical use. The results of the tumor-tracking dose verification system realized using SRSMC were equivalent to those of conventional methods, and this system is expected to contribute toward improving the efficiency of quality control in many facilities.

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  146. Contrast-Enhanced Fluid-Attenuated Inversion Recovery in Neuroimaging: A Narrative Review on Clinical Applications and Technical Advances. Reviewed International journal

    Sung Jun Ahn, Toshiaki Taoka, Won-Jin Moon, Shinji Naganawa

    Journal of magnetic resonance imaging : JMRI   Vol. 56 ( 2 ) page: 341 - 353   2022.8

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    While contrast-enhanced fluid-attenuated inversion recovery (FLAIR) has long been regarded as an adjunct sequence to evaluate leptomeningeal disease in addition to contrast-enhanced T1-weighted imaging, it is gradually being used for more diverse pathologies beyond leptomeningeal disease. Contrast-enhanced FLAIR is known to be highly sensitive to low concentrations of gadolinium within the fluid. Accordingly, recent research has suggested the potential utility of contrast-enhanced FLAIR in various kinds of disease, such as Meniere's disease, seizure, stroke, traumatic brain injury, and brain metastasis, in addition to being used for visualizing glymphatic dysfunction. However, its potential applications have been reported sporadically in an unorganized manner. Furthermore, the exact mechanism for its superior sensitivity to low concentrations of gadolinium has not been fully understood. Rapidly developing magnetic resonance technology and unoptimized parameters for FLAIR may challenge its accurate application in clinical practice. This review provides the fundamental mechanism of contrast-enhanced FLAIR, systematically describes its current and potential clinical application, and elaborates on technical considerations for its optimization. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY STAGE: 5.

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  147. The Incidence and Its Associated Factors Relevant to Brain Radionecrosis That Requires Intervention Following Single or Fractionated Stereotactic Radiosurgery Using Vero4DRT for Brain Metastases Reviewed

    Takehiro Yamada, Kazuhiro Ohtakara, Takeshi Kamomae, Junji Itoh, Hideki Shimada, Shunichi Ishihara, Shinji Naganawa

    CUREUS JOURNAL OF MEDICAL SCIENCE   Vol. 14 ( 6 ) page: e25888 - e25888   2022.6

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  148. Embolization using patient-specific vascular models created by a 3D printer for difficult cases: a report of two cases. Reviewed

    Tomohiro Komada, Takeshi Kamomae, Masaya Matsushima, Ryota Hyodo, Shinji Naganawa

    Nagoya journal of medical science   Vol. 84 ( 2 ) page: 477 - 483   2022.5

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    With the widespread use of three-dimensional printers, organ models created by these printers are now being used in the medical field for preoperative planning of surgeries. In this article, we report two cases in which embolization was expected to be difficult, and the three-dimensional printer-based vascular modeling was helpful in planning the surgery. The first case involved an aneurysm of the splenic artery. We attempted to embolize the aneurysm but were unable to advance the catheter into the distal artery and discontinued the procedure. The second case was a perianal varicose vein, which was initially treated with percutaneous transhepatic obliteration but was recanalized and required embolization. However, we expected difficulty in selecting the inferior mesenteric vein. In both cases, the vascular models were created using a 3D printer from the patients' computed tomography images. Preoperative planning, including treatment simulation, was based on these models. The time required to print a three-dimensional vascular model was approximately 12 hours at a cost of less than $10 each. Patient-specific vascular models using a three-dimensional printer can be a simple and inexpensive tool that can increase the success of embolization in difficult cases.

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  149. Letter to editor on the article "A non-invasive, automated diagnosis of Menière's disease using radiomics and machine learning on conventional magnetic resonance imaging: a multicentric, case-controlled feasibility study" by van der Lubbe Mfja et al. Reviewed International journal

    Shinji Naganawa, Rintaro Ito, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    La Radiologia medica   Vol. 127 ( 4 ) page: 458 - 459   2022.4

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  150. Does the Pulsatile Non-uniform Flow Matter in MR Flowmetry? Reviewed

    Masataka Sugiyama, Yasuo Takehara, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 21 ( 2 ) page: 365 - 371   2022.3

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    3D cine phase-contrast (4D flow) MRI is a sequence with great potential for non-invasive time-resolved 3D flowmetry at arbitrary vessel sections in various blood vessels. However, it is not widely known that the flowmetry with 4D flow MRI is vulnerable to pulsatile and non-uniform flow. Due to the limited spatial and temporal resolutions, averaging within the 3D voxel is occurring during the flowmetry. A simple solution is to avoid setting the measurement plane in the area where non-uniform flow is dominant, which is possible with an aid of streamline depictions generated by computational fluid dynamics (CFD) or 4D flow MRI data. Unlike 4D flow MRI, flowmetry in CFD simulation can use higher spatial and temporal resolution depending on computer performance; therefore, it is robust to fluctuating non-uniform flow. However, the performance of CFD simulations might be limited due to inlet conditions with low temporal resolution. Difficulty applying complex blood flow such as reflection flow from periphery may also limit accurate simulation. Caution should be taken when comparing the result of CFD simulation to that of 4D flow measurement.

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  151. Hybrid 3D T1-weighted gradient-echo sequence for fiducial marker detection and tumor delineation via magnetic resonance imaging in liver stereotactic body radiation therapy. Reviewed International journal

    Yutaka Kato, Takeshi Kamomae, Motoki Kumagai, Yumi Oie, Yumiko Noguchi, Kuniyasu Okudaira, Mariko Kawamura, Toshiaki Taoka, Shinji Naganawa

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)   Vol. 95   page: 9 - 15   2022.3

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    PURPOSE: Gold fiducial markers are used to guide liver stereotactic body radiation therapy (SBRT) and are hard to detect by magnetic resonance imaging (MRI). In this study, the parameters of the three-dimensional T1-weighted turbo gradient-echo (3D T1W-GRE) sequence were optimized for gold marker detection without degrading tumor delineation. METHODS: Custom-made phantoms mimicking tumor and normal liver parenchyma were prepared and embedded with a gold marker. The 3D T1W-GRE was scanned by varying echo time (TE), bandwidth (BW), flip angle (FA), and base matrix size. The signal-to-noise ratio (SNR), contrast ratio (CR), and relative standard deviation (RSD) of the signal intensity in the area including the gold marker were evaluated, and the parameters were optimized accordingly. The modified 3D T1W-GRE (called HYBRID) was compared with the conventional T1W-GRE- and T2*-sequences in both phantom and clinical studies. In the clinical study of six patients with primary liver tumors, two observers visually assessed marker detection, tumor delineation, and overall image quality on a four-point scale. RESULTS: In the phantom study, HYBRID showed significantly higher SNR and RSD than those of conventional T1W-GRE (P < 0.001). In the clinical study, HYBRID yielded significantly higher scores than conventional T1W-GRE did in terms of marker detection (P < 0.001). The scores of both sequences were not statistically different in terms of tumor delineation and overall image quality (P = 0.56 and P = 0.32). CONCLUSIONS: The proposed HYBRID sequence improved gold fiducial marker detection without degrading tumor delineation in MRI for SBRT of primary liver tumor.

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  152. 歪みのないMRI拡散強調画像の放射線治療計画への臨床応用 Reviewed

    加藤 裕, 奥平 訓康, 丸山 克也, 田岡 俊昭, 長縄 慎二

    日本放射線技術学会総会学術大会予稿集   Vol. 78回   page: 169 - 169   2022.3

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  153. 17O標識水と市販点眼薬の画像化に向けた初期検討 Ultra-heavily T2強調画像の可能性 Invited

    加藤 裕, 山口 博司, 田岡 俊昭, 長縄 慎二

    日本放射線技術学会総会学術大会予稿集   Vol. 78回   page: 190 - 190   2022.3

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  154. コークスクリュー型高速パラレルイメージング併用3D-FLAIRシーケンスの基礎的検討 Reviewed

    加藤 裕, 田岡 俊昭, 丸山 克也, 長縄 慎二

    日本放射線技術学会総会学術大会予稿集   Vol. 78回   page: 214 - 214   2022.3

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  155. Water Diffusivity Changes Along the Perivascular Space After Lumboperitoneal Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus. Reviewed International journal

    Junko Kikuta, Koji Kamagata, Toshiaki Taoka, Kaito Takabayashi, Wataru Uchida, Yuya Saito, Christina Andica, Akihiko Wada, Kaito Kawamura, Chihiro Akiba, Madoka Nakajima, Masakazu Miyajima, Shinji Naganawa, Shigeki Aoki

    Frontiers in neurology   Vol. 13   page: 843883 - 843883   2022.2

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    Background: The aim of this study was to evaluate the water diffusivity changes along the perivascular space after lumboperitoneal shunt (LPS) surgery in idiopathic normal pressure hydrocephalus. Methods: Nine patients diagnosed with idiopathic normal pressure hydrocephalus (iNPH; three men and six women, mean age ± SD = 75.22 ± 5.12 years) according to the guidelines for iNPH in Japan were included in the study. Post-LPS surgery, six patients with iNPH who exhibited improvement in symptoms were defined as responder subjects, while three patients with iNPH who did not were defined as non-responder subjects. We calculated the mean analysis along the perivascular space (ALPS) index of the left and right hemispheres and compared the differences between pre- and post-LPS surgery mean ALPS indices in iNPH patients. In the responder or non-responder subjects, the mean ALPS indices in the pre- and post-operative iNPH groups were compared using Wilcoxon signed-rank tests. Next, correlation analyses between pre- and post-operation changes in the mean ALPS index and clinical characteristics were conducted. Results: The mean ALPS index of the post-operative iNPH group was significantly higher than that of the pre-operative iNPH group (p = 0.021). In responder subjects, the mean ALPS index of the post-operative iNPH group was significantly higher than that of the pre-operative iNPH group (p = 0.046). On the other hand, in the non-responder subjects, the mean ALPS index of the post-operative iNPH group was not significantly different compared to the pre-operative iNPH group (p = 0.285). The mean ALPS index change was not significantly correlated with changes in the Mini-Mental State Examination (MMSE) score (r = -0.218, p = 0.574), Frontal Assessment Battery (FAB) score (r = 0.185, p = 0.634), Trail Making Test A (TMTA) score (r = 0.250, p = 0.516), and Evans' index (r = 0.109, p = 0.780). In responder subjects, the mean ALPS index change was significantly correlated with Evans' index in pre-operative patients with iNPH (r = 0.841, p = 0.036). Conclusion: This study demonstrates the improved water diffusivity along perivascular space in patients with iNPH after LPS surgery. This could be indicative of glymphatic function recovery following LPS surgery.

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  156. 中枢神経原発の成人T細胞白血病・リンパ腫の1例 Reviewed

    長井 尚哉, 川井 恒, 田岡 俊昭, 伊藤 信嗣, 長縄 慎二, 加賀谷 裕介, 寺倉 精太郎, 横井 聡, 勝野 雅央, 河野 奨, 下山 芳江

    Japanese Journal of Radiology   Vol. 40 ( Suppl. ) page: 25 - 25   2022.2

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  157. Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study. Reviewed

    Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Koji Kamagata, Mayuko Sakai, Hisashi Kawai, Toshiki Nakane, Takashi Abe, Kazushige Ichikawa, Junko Kikuta, Shigeki Aoki, Shinji Naganawa

    Japanese journal of radiology   Vol. 40 ( 2 ) page: 147 - 158   2022.2

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    PURPOSE: The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was developed to evaluate the brain's glymphatic function or interstitial fluid dynamics. This study aimed to evaluate the reproducibility of the DTI-ALPS method and the effect of modifications in the imaging method and data evaluation. MATERIALS AND METHODS: Seven healthy volunteers were enrolled in this study. Image acquisition was performed for this test-retest study using a fixed imaging sequence and modified imaging methods which included the placement of region of interest (ROI), imaging plane, head position, averaging, number of motion-proving gradients, echo time (TE), and a different scanner. The ALPS-index values were evaluated for the change of conditions listed above. RESULTS: This test-retest study by a fixed imaging sequence showed very high reproducibility (intraclass coefficient = 0.828) for the ALPS-index value. The bilateral ROI placement showed higher reproducibility. The number of averaging and the difference of the scanner did not influence the ALPS-index values. However, modification of the imaging plane and head position impaired reproducibility, and the number of motion-proving gradients affected the ALPS-index value. The ALPS-index values from 12-axis DTI and 3-axis diffusion-weighted image (DWI) showed good correlation (r = 0.86). Also, a shorter TE resulted in a larger value of the ALPS-index. CONCLUSION: ALPS index was robust under the fixed imaging method even when different scanners were used. ALPS index was influenced by the imaging plane, the number of motion-proving gradient axes, and TE in the imaging sequence. These factors should be uniformed in the planning ALPS method studies. The possibility to develop a 3-axis DWI-ALPS method using three axes of the motion-proving gradient was also suggested.

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  158. <Editors' Choice> Evaluation of system-related magnetic resonance imaging geometric distortion in radiation therapy treatment planning: two approaches and effectiveness of three-dimensional distortion correction. Reviewed

    Yutaka Kato, Kuniyasu Okudaira, Takeshi Kamomae, Motoki Kumagai, Youta Nagai, Toshiaki Taoka, Yoshiyuki Itoh, Shinji Naganawa

    Nagoya journal of medical science   Vol. 84 ( 1 ) page: 29 - 41   2022.2

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    We propose two methods to evaluate system-related distortion in magnetic resonance imaging (MRI) in radiation therapy treatment planning (RTP) and demonstrate the importance of three-dimensional (3D) distortion correction (DC) by quantitatively measuring the distortion magnitude. First, a small pin phantom was scanned at multiple positions using an external laser guide for accurate phantom placement and combined into one image encompassing a large area. Direct plane images were used for evaluating in-plane distortion and multiplanar reconstruction images for through-plane distortion with no DC, two-dimensional (2D) DC, and 3D DC. Second, a large grid sheet was scanned as the direct plane of the phantom placement. The distortion magnitude was determined by measuring the displacement between the MRI and reference coordinates. The measured distortions were compared between in- and through-plane when applying DC and between the two methods. The small pin phantom method can be used to evaluate a wide range of distortions, whereas data from the entire plane can be obtained with a single scan using the grid sheet without a laser guide. The mean distortion magnitudes differed between the methods. Furthermore, the 3D DC reduced in- and through-plane distortions. In conclusion, the small pin phantom method can be used to evaluate a wide range of distortions by creating a combined image, whereas the grid sheet method is simpler, accurate, repeatable, and does not require a special-order phantom or laser guide. As 3D DC reduces both in- and through-plane distortions, it can be used to improve RTP quality.

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  159. Labyrinthitis With Endolymphatic Hydrops Revealed by Imaging Analysis in a Case With Severe Postoperative Complications Following Stapes Surgery. Reviewed International journal

    Masumi Kobayashi, Tadao Yoshida, Yasue Uchida, Satofumi Sugimoto, Shinji Naganawa, Michihiko Sone

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   Vol. 43 ( 1 ) page: E134 - E136   2022.1

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    DOI: 10.1097/MAO.0000000000003328

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  160. Features from MRI texture analysis associated with survival outcomes in triple-negative breast cancer patients. Reviewed

    Saki Kamiya, Hiroko Satake, Yoko Hayashi, Satoko Ishigaki, Rintaro Ito, Mariko Kawamura, Toshiaki Taoka, Shingo Iwano, Shinji Naganawa

    Breast cancer (Tokyo, Japan)   Vol. 29 ( 1 ) page: 164 - 173   2022.1

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    PURPOSE: The purpose of the study is to evaluate the associations between intratumoral or peritumoral textural features derived from pretreatment magnetic resonance imaging (MRI) and recurrence-free survival (RFS) in triple-negative breast cancer (TNBC) patients. METHODS: Forty-three patients with TNBC who underwent preoperative MRI between February 2008 and March 2014 were included. We performed two-dimensional texture analysis on the intratumoral or peritumoral region of interest (ROI) on axial of T2-weighted image (T2WI), dynamic contrast-enhanced (DCE)-MRI and DCE-MRI subtraction images. We also analyzed histopathological data. Cox proportional hazards models were used to investigate associations with survival outcomes. RESULTS: Twelve of the 43 patients (27.9%) had recurrence disease, at a median of 32.5 months follow-up (1.4-61.5 months). In univariate analysis, nine texture features in T2WI and DCE-MRI subtraction images were significantly associated with RFS. In multivariate analysis, intratumoral difference entropy in DCE-MRI subtraction images in the initial phase (hazard ratio 11.71; 95% confidence interval (CI) [1.41, 97.00]; p value 0.023) and, peritumoral difference variance in DCE-MRI subtraction images in the delayed phase (hazard ratio 9.60; 95% CI [1.98, 46.51]; p value 0.005), were both independently associated with RFS. Moreover, multivariate analysis revealed the presence of lymphovascular invasion as independently associated with RFS (hazard ratio 8.13; 95% CI [2.16, 30.30]; p value 0.002). CONCLUSIONS: At pretreatment MRI, an intratumoral and peritumoral quantitative approach using texture analysis has the potential to serve as a prognostic marker in patients with TNBC.

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  161. Radiomics in breast MRI: current progress toward clinical application in the era of artificial intelligence. Reviewed International journal

    Hiroko Satake, Satoko Ishigaki, Rintaro Ito, Shinji Naganawa

    La Radiologia medica   Vol. 127 ( 1 ) page: 39 - 56   2022.1

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    Breast magnetic resonance imaging (MRI) is the most sensitive imaging modality for breast cancer diagnosis and is widely used clinically. Dynamic contrast-enhanced MRI is the basis for breast MRI, but ultrafast images, T2-weighted images, and diffusion-weighted images are also taken to improve the characteristics of the lesion. Such multiparametric MRI with numerous morphological and functional data poses new challenges to radiologists, and thus, new tools for reliable, reproducible, and high-volume quantitative assessments are warranted. In this context, radiomics, which is an emerging field of research involving the conversion of digital medical images into mineable data for clinical decision-making and outcome prediction, has been gaining ground in oncology. Recent development in artificial intelligence has promoted radiomics studies in various fields including breast cancer treatment and numerous studies have been conducted. However, radiomics has shown a translational gap in clinical practice, and many issues remain to be solved. In this review, we will outline the steps of radiomics workflow and investigate clinical application of radiomics focusing on breast MRI based on published literature, as well as current discussion about limitations and challenges in radiomics.

    DOI: 10.1007/s11547-021-01423-y

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  162. Reserve and maintenance in the aging brain: A longitudinal study of healthy older adults. Reviewed International journal

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Kazuya Kawabata, Kazuhiro Hara, Reiko Ohdake, Aya Ogura, Daisuke Mori, Noritaka Yoneyama, Kazunori Imai, Takamasa Yokoi, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

    eNeuro   Vol. 9 ( 1 ) page: 0455-21 - 0455-21   2022.1

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    The aging brain undergoes structural changes even in very healthy individuals. Quantifying these changes could help disentangle pathological changes from those associated with the normal human aging process. Using longitudinal MRI data from 227 carefully selected healthy human cohort with age ranging from 50 to 80 years old at baseline scan, we quantified age-related volumetric changes in the brain of healthy human older adults. Longitudinally, the rates of tissue loss in total gray matter (GM) and white matter were 2,497.5 mm3 per year and 2,579.8 mm3 per year, respectively. Across the whole brain, the rates of GM decline varied with regions in the frontal and parietal lobes having faster rates of decline, whereas some regions in the occipital and temporal lobes appeared relatively preserved. In contrast, cross sectional changes were mainly observed in the temporal-occipital regions. Similar longitudinal atrophic changes were also observed in subcortical regions including thalamus, hippocampus, putamen, and caudate, whereas the pallidum showed an increasing volume with age. Overall, regions maturing late in development (frontal, parietal) are more vulnerable to longitudinal decline, whereas those that fully mature in the early stage (temporal, occipital) are mainly affected by cross sectional changes in healthy older cohort. This may suggest that, for a successful healthy aging, the former needs to be maximally developed at an earlier age to compensate for the longitudinal decline later in life and the latter to remain relatively preserved even in old age, consistent with both concepts of reserve and brain maintenance.Significance StatementAging is associated with gray matter (GM) decline, yet some individuals tend to remain cognitively healthy even in advanced age. What differentiates the brains of "healthy agers" from those individuals who are prone to faster cognitive decline still remains unclear. Using longitudinal MRI data from a carefully selected cohort, we examined the brain aging characteristics of healthy agers. Our findings showed that, even in this population, frontal-parietal regions have faster longitudinal rate of GM decline, whereas some temporal-occipital regions appeared relatively preserved. These findings may suggest that, for a successful healthy aging, frontal-parietal regions need to be maximally developed to compensate for the longitudinal decline later in life and the temporal-occipital regions to remain relatively preserved even in old age.

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  163. An Investigation of Water Diffusivity Changes along the Perivascular Space in Elderly Subjects with Hypertension Reviewed

    J. Kikuta, K. Kamagata, K. Takabayashi, T. Taoka, H. Yokota, C. Andica, A. Wada, Y. Someya, Y. Tamura, R. Kawamori, H. Watada, S. Naganawa, S. Aoki

    American Journal of Neuroradiology   Vol. 43 ( 1 ) page: 48 - 55   2022.1

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    DOI: 10.3174/ajnr.A7334

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  164. The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging. Reviewed

    Shinji Naganawa, Toshiaki Taoka

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 21 ( 1 ) page: 182 - 194   2022

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    The central nervous system (CNS) was previously thought to be the only organ system lacking lymphatic vessels to remove waste products from the interstitial space. Recently, based on the results from animal experiments, the glymphatic system was hypothesized. In this hypothesis, cerebrospinal fluid (CSF) enters the periarterial spaces, enters the interstitial space of the brain parenchyma via aquaporin-4 (AQP4) channels in the astrocyte end feet, and then exits through the perivenous space, thereby clearing waste products. From the perivenous space, the interstitial fluid drains into the subarachnoid space and meningeal lymphatics of the parasagittal dura. It has been reported that the glymphatic system is particularly active during sleep. Impairment of glymphatic system function might be a cause of various neurodegenerative diseases such as Alzheimer's disease, normal pressure hydrocephalus, glaucoma, and others. Meningeal lymphatics regulate immunity in the CNS. Many researchers have attempted to visualize the function and structure of the glymphatic system and meningeal lymphatics in vivo using MR imaging. In this review, we aim to summarize these in vivo MR imaging studies and discuss the significance, current limitations, and future directions. We also discuss the significance of the perivenous cyst formation along the superior sagittal sinus, which is recently discovered in the downstream of the glymphatic system.

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  165. Cross-sectional Area of the Superior Petrosal Sinus is Reduced in Patients with Significant Endolymphatic Hydrops. Reviewed

    Shinji Naganawa, Rintaro Ito, Hisashi Kawai, Mariko Kawamura, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 21 ( 3 ) page: 459 - 467   2022

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    PURPOSE: To evaluate the relationship between the size of the venous structures related to the inner ear and the degree of endolymphatic hydrops (EH). METHODS: Thirty-four patients with a suspicion of EH underwent whole brain MR imaging including the inner ear. Images were obtained pre- and post-administration, and at 4 and 24 hours after the intravenous administration of a gadolinium-based contrast agent (IV-GBCA). The cross-sectional areas (CSA) of the internal jugular vein (IJV), superior petrosal sinus (SPS), and inferior petrosal sinus (IPS) were measured on the magnetization prepared rapid acquisition of gradient echo (MPRAGE) images obtained immediately after the IV-GBCA. The grade of EH was determined on the hybrid of reversed image of positive endolymph signal and native image of positive perilymph signal (HYDROPS) images obtained at 4 hours after IV-GBCA as no, mild, and significant EH according to the previously proposed grading system for the cochlea and vestibule, respectively. The ipsilateral CSA was compared between groups with each level of EH grade. P < 0.05 was considered statistically significant. RESULTS: There were no statistically significant differences between EH grades for the CSA of the IJV or that of the IPS in either the cochlea or the vestibule. The CSA of the SPS in the groups with significant EH was significantly smaller than that in the group with no EH, for both the cochlea (P < 0.01) and the vestibule (P < 0.05). In an ROC analysis to predict significant EH, the cut-off CSA value in the SPS was 3.905 mm2 for the cochlea (AUC: 0.8762, 95% confidence interval [CI]: 0.7952‒0.9572) and 3.805 mm2 for the vestibule (AUC: 0.7727, 95% CI: 0.6539‒0.8916). CONCLUSION: In the ears with significant EH in the cochlea or vestibule, the CSA of the ipsilateral SPS was smaller than in the ears without EH.

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  166. MR Imaging of Endolymphatic Hydrops in Five Minutes. Reviewed

    Shinji Naganawa, Rintaro Ito, Hisashi Kawai, Mariko Kawamura, Toshiaki Taoka, Mayuko Sakai, Kazushige Ichikawa, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 21 ( 3 ) page: 401 - 405   2022

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    In this study, we present images acquired by a fast-imaging method for the evaluation of endolymphatic hydrops after intravenous administration of a single dose of gadolinium-based contrast agent. We utilized the hybrid of reversed image of MR cisternography and a positive perilymph signal by heavily T2- weighted 3D-fluid attenuated inversion recovery-multiplied by T2 (HYDROPS2-Mi2) method combined with deep learning reconstruction denoising. The scan time for the fast protocol was approximately 5 mins, which is far shorter than previously reported scan times. The fast acquisition provides similar image quality and less motion artifacts compared to the longer method.

    DOI: 10.2463/mrms.ici.2021-0022

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  167. Effects of Head Motion on the Evaluation of Age-related Brain Network Changes Using Resting State Functional MRI. Reviewed

    Sanae Kato, Epifanio Bagarinao, Haruo Isoda, Shuji Koyama, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Masahisa Katsuno, Minoru Hoshiyama, Shinji Naganawa, Norio Ozaki, Gen Sobue

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 4 ) page: 338 - 346   2021.12

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    PURPOSE: The estimation of functional connectivity (FC) measures using resting state functional MRI (fMRI) is often affected by head motion during functional imaging scans. Head motion is more common in the elderly than in young participants and could therefore affect the evaluation of age-related changes in brain networks. Thus, this study aimed to investigate the influence of head motion in FC estimation when evaluating age-related changes in brain networks. METHODS: This study involved 132 healthy volunteers divided into 3 groups: elderly participants with high motion (OldHM, mean age (±SD) = 69.6 (±5.31), N = 44), elderly participants with low motion (OldLM, mean age (±SD) = 68.7 (±4.59), N = 43), and young adult participants with low motion (YugLM, mean age (±SD) = 27.6 (±5.26), N = 45). Head motion was quantified using the mean of the framewise displacement of resting state fMRI data. After preprocessing all resting state fMRI datasets, several resting state networks (RSNs) were extracted using independent component analysis (ICA). In addition, several network metrics were also calculated using network analysis. These FC measures were then compared among the 3 groups. RESULTS: In ICA, the number of voxels with significant differences in RSNs was higher in YugLM vs. OldLM comparison than in YugLM vs. OldHM. In network analysis, all network metrics showed significant (P < 0.05) differences in comparisons involving low vs. high motion groups (OldHM vs. OldLM and OldHM vs. YugLM). However, there was no significant (P > 0.05) difference in the comparison involving the low motion groups (OldLM vs. YugLM). CONCLUSION: Our findings showed that head motion during functional imaging could significantly affect the evaluation of age-related brain network changes using resting state fMRI data.

    DOI: 10.2463/mrms.mp.2020-0081

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  168. Evaluating the Effect of Arterial Pulsation on Cerebrospinal Fluid Motion in the Sylvian Fissure of Patients with Middle Cerebral Artery Occlusion Using Low b-value Diffusion-weighted Imaging Reviewed

    Toshiaki Taoka, Hisashi Kawai, Toshiki Nakane, Takashi Abe, Rei Nakamichi, Rintaro Ito, Yutaro Sasaki, Ayumi Nishida, Shinji Naganawa

    Magnetic Resonance in Medical Sciences   Vol. 20 ( 4 ) page: 371 - 377   2021.12

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    DOI: 10.2463/mrms.mp.2020-0121

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  169. Incidental findings on computed tomography for preoperative assessment before transcatheter aortic valve implantation in Japanese patients. Reviewed

    Akihiro Tobe, Akihito Tanaka, Yoshiyuki Tokuda, Yusuke Miki, Kenji Furusawa, Sho Akita, Taro Fujii, Yoshinori Tsutsumi, Hideki Ishii, Shingo Iwano, Shinji Naganawa, Akihiko Usui, Toyoaki Murohara

    Heart and vessels   Vol. 36 ( 12 ) page: 1911 - 1922   2021.12

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    Extra-cardiovascular incidental findings (IFs) on preoperative computed tomography (CT) are frequently observed in transcatheter aortic valve implantation (TAVI) candidates. However, the backgrounds of TAVI candidates and comorbidities differ based on the race and/or country, and data on IFs in a specific population are not always applicable to another. The aim of this study was to assess the prevalence, type, and clinical impact of IFs in Japanese TAVI candidates. This was a retrospective, single-center, observational study. CT reports of 257 TAVI candidates were reviewed, and IFs were classified as (a) insignificant: findings that did not require further investigation, treatment, or follow-up; (b) intermediate: findings that needed to be followed up or were considered for further investigation but did not affect the planning of TAVI; and (c) significant: findings that required further investigation immediately or affected the planning of TAVI. At least one IF was found in 254 patients (98.8%). Insignificant, intermediate, and significant IFs were found in 253 (98.4%), 153 (59.5%), and 34 (13.2%) patients, respectively. Newly indicated significant IFs were found in 19 patients (7.4%). In 2 patients (0.8%), TAVI was canceled because of significant IFs. In patients who consequently underwent TAVI, the presence of significant IFs was not associated with the duration from CT performance to TAVI [28 (19-40) days vs. 27 (19-43) days, p = 0.74] and all-cause mortality during the median follow-up period of 413 (223-805) days (p = 0.44). Almost all Japanese TAVI candidates had at least one IF, and the prevalence of significant IFs was not negligible. Although the presence of significant IFs was not associated with mid-term mortality, appropriate management of IFs was considered important.

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  170. FLUID study: study protocol for an open-label, single-centre pilot study to investigate the efFect of Lemborexant on sleep management in Japanese sUbjects aged 50 years and older with Insomnia Disorder. Reviewed International journal

    Ippei Okada, Kunihiro Iwamoto, Seiko Miyata, Akihiro Fujimoto, Masaki Tanaka, Manabu Amano, Nao Matsuyama, Toshiaki Taoka, Shinji Naganawa, Norio Ozaki

    BMJ open   Vol. 11 ( 11 ) page: e054885   2021.11

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    INTRODUCTION: Bidirectional associations have been reported between sleep disturbance and both cognitive impairment, including Alzheimer's disease and amyloid beta-peptide (Aβ) accumulation. These relationships can be explained by the glymphatic system, which acts as a garbage drainage system in the brain. As interstitial fluid dynamics are suggested to increase during sleep, clearance of Aβ can be influenced by sleep disturbance or deprivation. We hypothesised that using lemborexant, an orexin receptor antagonist, to improve sleep quality would also improve the function of the glymphatic system. We plan to examine the effect of lemborexant on sleep quality and the glymphatic system among patients with insomnia disorder. METHODS AND ANALYSIS: This pilot study is designed as an open-label, single-arm, single-centre trial. Thirty patients aged 50 years and over with insomnia will be recruited. The participants will take lemborexant (5 mg) at bedtime for 12 weeks and undergo a home-based sleep study at baseline and weeks 4 and 12, as well as MRI examinations to evaluate the glymphatic system at baseline and week 12. The primary outcome will be changes in objective sleep parameters as evaluated using a sleep monitoring system. The secondary outcomes will be changes in subjective sleep parameters. The relationships between changes in sleep parameters and the glymphatic system will be evaluated using diffusion tensor image analysis along the perivascular space, which is called the ALPS-index. Sleep parameters and the ALPS-index will be analysed using a paired t-test or Pearson's correlation coefficient. ETHICS AND DISSEMINATION: The study protocol was approved by Nagoya University Certified Review Board. The findings from this research will be published in peer-reviewed journals and be presented at local, national and international conferences. TRIAL REGISTRATION NUMBER: jRCTs041210024.

    DOI: 10.1136/bmjopen-2021-054885

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  171. Development of an x-ray-opaque-marker system for quantitative phantom positioning in patient-specific quality assurance Reviewed

    Kentaro Suzuki, Takeshi Kamomae, Hiroshi Oguchi, Fumitaka Kawabata, Kazuma Sugita, Kuniyasu Okudaira, Masaki Mori, Shinji Abe, Masataka Komori, Mariko Kawamura, Kazuhiro Ohtakara, Yoshiyuki Itoh, Shinji Naganawa

    Physica Medica   Vol. 91   page: 121 - 130   2021.11

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    DOI: 10.1016/j.ejmp.2021.10.017

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  172. A case of intraductal tubulopapillary neoplasm of the pancreas originating from the branch duct: cast in the mold sign. Reviewed

    Ryota Horiguchi, Hiroshi Ogawa, Naoya Nagai, Yasuo Takehara, Shinji Naganawa, Yukihiro Yokoyama, Yoshie Shimoyama

    Nagoya journal of medical science   Vol. 83 ( 4 ) page: 869 - 875   2021.11

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    A 59-year-old man with jaundice and lower common bile duct stenosis was referred to our institution for diagnosis and treatment. Computed tomography and magnetic resonance imaging showed a well-circumscribed smoothly marginated solid mass lesion in the pancreatic head. He underwent pyloric preserving pancreatoduodenectomy. Histopathological specimen revealed that the mass was located in the dilated branch duct of the pancreatic head, and an intraductal tubulopapillary neoplasm originating from the branch pancreatic duct was diagnosed. On magnetic resonance cholangiopancreatography, the mass within the dilated duct branch in the pancreatic head was similar to a "cast in the mold" image, which we retrospectively deemed, might be reflecting the nature of this tumor.

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  173. Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus. Reviewed International journal

    Kazuya Kawabata, Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Reiko Ohdake, Michihito Masuda, Aya Ogura, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

    iScience   Vol. 24 ( 10 ) page: 103106 - 103106   2021.10

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    The thalamus is critical for the brain's integrative hub functions; however, the localization and characterization of the different thalamic hubs remain unclear. Using a voxel-level network measure called functional connectivity overlap ratio (FCOR), we examined the thalamus' association with large-scale resting-state networks (RSNs) to elucidate its connector hub roles. Connections to the core-neurocognitive networks were localized in the anterior and medial parts, such as the anteroventral and mediodorsal nuclei areas. Regions functionally connected to the sensorimotor network were distinctively located around the lateral pulvinar nucleus but to a limited extent. Prominent connector hubs include the anteroventral, ventral lateral, and mediodorsal nuclei with functional connections to multiple RSNs. These findings suggest that the thalamus, with extensive connections to most of the RSNs, is well placed as a critical integrative functional hub and could play an important role for functional integration facilitating brain functions associated with primary processing and higher cognition.

    DOI: 10.1016/j.isci.2021.103106

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  174. Magnetic resonance cisternography imaging findings related to the leakage of Gadolinium into the subarachnoid space Reviewed

    Rei Nakamichi, Toshiaki Taoka, Hisashi Kawai, Tadao Yoshida, Michihiko Sone, Shinji Naganawa

    Japanese Journal of Radiology   Vol. 39 ( 10 ) page: 927 - 937   2021.10

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    <title>Abstract</title><sec>
    <title>Purpose</title>
    To identify magnetic resonance cisternography (MRC) imaging findings related to Gadolinium-based contrast agent (GBCA) leakage into the subarachnoid space.


    </sec><sec>
    <title>Materials and methods</title>
    The number of voxels of GBCA leakage (V-leak) on 3D-real inversion recovery images was measured in 56 patients scanned 4 h post-intravenous GBCA injection. Bridging veins (BVs) were identified on MRC. The numbers of BVs with surrounding cystic structures (BV-cyst), with arachnoid granulations protruding into the superior sagittal sinus (BV-AG-SSS) and the skull (BV-AG-skull), and including any of these factors (BV-incl) were recorded. Correlations between these variables and V-leak were examined based on the Spearman’s rank correlation coefficient. Receiver-operating characteristic (ROC) curves were generated to investigate the predictive performance of GBCA leakage.


    </sec><sec>
    <title>Results</title>
    V-leak and the number of BV-incl were strongly correlated (<italic>r</italic> = 0.609, <italic>p</italic> &lt; 0.0001). The numbers of BV-cyst and BV-AG-skull had weaker correlations with V-leak (<italic>r</italic> = 0.364, <italic>p</italic> = 0.006; <italic>r</italic> = 0.311, <italic>p</italic> = 0.020, respectively). The number of BV-AG-SSS was not correlated with V-leak. The ROC curve for contrast leakage exceeding 1000 voxels and the number of BV-incl had moderate accuracy, with an area under the curve of 0.871.


    </sec><sec>
    <title>Conclusion</title>
    The number of BV-incl may be a predictor of GBCA leakage and a biomarker for waste drainage function without using GBCA.



    </sec>

    DOI: 10.1007/s11604-021-01137-1

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    Other Link: https://link.springer.com/article/10.1007/s11604-021-01137-1/fulltext.html

  175. Imaging diagnosis of autoimmune pancreatitis: computed tomography and magnetic resonance imaging. Reviewed

    Hiroshi Ogawa, Yasuo Takehara, Shinji Naganawa

    Journal of medical ultrasonics (2001)   Vol. 48 ( 4 ) page: 565 - 571   2021.10

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    Autoimmune pancreatitis (AIP) is a pancreatic phenotype of IgG4-related systemic disease. Since its first description in the literature, characteristic imaging features have gradually become known to many clinicians encompassing various specialties in the past quarter century. CT and MRI have been the workhorses for imaging diagnosis of AIP. Typical features include sausage-like swelling of the focal or entire pancreas, duct-penetrating sign, a capsule-like rim of the affected lesions, and homogeneous delayed enhancement or enhanced duct sign after contrast administration, as well as characteristic combined findings reflecting coexisting pathologies in the other organs as a systemic disease. In this review, recent and future developments in CT and MRI that may help diagnose AIP are discussed, including restricted diffusion and perfusion and increased elasticity measured using MR.

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  176. The importance of choosing the right strategy to treat small cell carcinoma of the cervix: a comparative analysis of treatments. Reviewed International journal

    Mariko Kawamura, Yutaro Koide, Taro Murai, Shunichi Ishihara, Yuuki Takase, Takayuki Murao, Dai Okazaki, Takahiro Yamaguchi, Kaoru Uchiyama, Yoshiyuki Itoh, Takeshi Kodaira, Yuta Shibamoto, Mika Mizuno, Fumitaka Kikkawa, Shinji Naganawa

    BMC cancer   Vol. 21 ( 1 ) page: 1046 - 1046   2021.9

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    BACKGROUND: Standard treatments for small cell carcinoma of the cervix (SCCC) have not been established. In this study, we aimed to estimate the optimal treatment strategy for SCCC. METHODS: This was a multicenter retrospective study. Medical records of patients with pathologically proven SCCC treated between 2003 and 2016 were retrospectively analyzed. Overall survival (OS) was plotted using the Kaplan-Meier method. Log-rank tests and Cox regression analysis were used to assess the differences in survival according to stage, treatment strategy, and chemotherapy regimen. RESULTS: Data of 78 patients were collected, and after excluding patients without immunohistopathological staining, 65 patients were evaluated. The median age of the included patients was 47 (range: 24-83) years. The numbers of patients with International Federation of Gynecology and Obstetrics (FIGO) 2018 stages I-IIA, IIB-IVA, IVB were 23 (35%), 34 (52%), and 8 (12%), respectively. Of 53 patients who had undergone chemotherapy, 35 and 18 received SCCC and non-SCCC regimens as their first-line chemotherapy regimen, respectively. The 5-year OS for all patients was 49%, while for patients with FIGO stages I-IIA, IIB-IVA, IVB, it was 60, 50, and 0%, respectively. The 5-year OS rates for patients who underwent treatment with SCCC versus non-SCCC regimens were 59 and 13% (p < 0.01), respectively. This trend was pronounced in locally advanced stages. Multivariate analysis showed that FIGO IVB at initial diagnosis was a significant prognostic factor in all patients. Among the 53 patients who received chemotherapy, the SCCC regimen was associated with significantly better 5-year OS in both the uni- and multivariate analyses. CONCLUSION: Our results suggest that the application of an SCCC regimen such as EP or IP as first-line chemotherapy for patients with locally advanced SCCC may play a key role in OS. These findings need to be validated in future nationwide, prospective clinical studies.

    DOI: 10.1186/s12885-021-08772-x

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  177. Changes in Vessel Wall Enhancement Related to the Recent Neurological Symptoms in Patients with Moyamoya Disease. Reviewed

    Shinsuke Muraoka, Toshiaki Taoka, Hisashi Kawai, Sho Okamoto, Kenji Uda, Shinji Naganawa, Yoshio Araki

    Neurologia medico-chirurgica   Vol. 61 ( 9 ) page: 515 - 520   2021.9

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    Moyamoya disease (MMD) causes intracranial arterial stenosis progression. The progression of intracranial arterial stenosis will increase the risk of ischemic cerebrovascular events. This study aims to investigate the relationship between intracranial arterial stenosis progression, vessel wall enhancement (VWE), and the recent neurological symptoms. A total of 39 MMD patients (12 male; 37.6 ± 18.0 years old) were registered in this study analysis between April 2016 and July 2018. All patients received MRI at registration and 6, 12, and 24 months post-registration. The incidence of ischemic cerebrovascular events (transit ischemic attacks or cerebral infarction) was checked until December 2018. We evaluated the relationship between the intensity of VWE, intracranial arterial stenosis, and the recent neurological symptoms. During the mean follow-up period of 13.8 ± 5.5 months, the changes in VWE were observed in 33 hemispheres (42.3%), stenosis progression was observed in 21 hemispheres (26.9%), and recent neurological symptoms occurred in 10 hemispheres (12.8%). Stenosis progression was observed in 11 hemispheres (33.3%) in the VWE(+) group and ten hemispheres (22.2%) in the VWE(-) group (p = 0.310). The recent neurological symptoms were observed in eight hemispheres (21.2%) in the VWE(+) group and two hemispheres (4.44%) in the VWE(-) group (odds ratio 6.88, 95% confidence interval 1.35-34.98, p = 0.015). The intensity of VWE sometimes changes. The changes in VWE were significantly associated with the recent neurological symptoms but not with stenosis progression.

    DOI: 10.2176/nmc.oa.2021-0058

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  178. Evaluation of the blood-perilymph barrier in ears with endolymphatic hydrops. Reviewed International journal

    Tadao Yoshida, Masumi Kobayashi, Satofumi Sugimoto, Masaaki Teranishi, Shinji Naganawa, Michihiko Sone

    Acta oto-laryngologica   Vol. 141 ( 8 ) page: 736 - 741   2021.8

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    BACKGROUND: Otological diseases including Meniere's disease (MD) involve endolymphatic hydrops (EH), which can be visualized by magnetic resonance imaging (MRI) with gadolinium contrast agents, but the temporal changes of contrast in the inner ear have not been evaluated. OBJECTIVES: We investigated the permeability of the blood-perilymph barrier (BPB) in ears with EH to evaluate the severity of the inner ear disturbances. MATERIALS AND METHODS: The study included 32 ears from 16 patients with EH or related diseases who underwent MRI. The permeability of the BPB was assessed by the signal-intensity ratio (SIR) at four-time points: before and at 10 min, 4 h, and 24 h after administration of gadolinium for assessing EH. RESULTS: Cochlear EH was found in 25 of the 32 ears, and vestibular EH in 11. The rate of EH was significantly higher in symptomatic ears; however, the existence of EH was not related to SIR values. Nevertheless, SIR values in the basal turn were significantly higher 4 and 24 h after injection of gadolinium in patients aged ≥50 years. CONCLUSION AND SIGNIFICANCE: Higher SIR values observed in older patients with EH indicate severe disturbances of the BPB in the cochlea, which may account for intractable inner ear disturbances in older patients.

    DOI: 10.1080/00016489.2021.1957500

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  179. Dilatation of the Endolymphatic Space in the Ampulla of the Posterior Semicircular Canal: A New Clinical Finding Detected on Magnetic Resonance Imaging. Reviewed International journal

    Masaru Morioka, Satofumi Sugimoto, Tadao Yoshida, Masaaki Teranishi, Masumi Kobayashi, Naoki Nishio, Naomi Katayama, Shinji Naganawa, Michihiko Sone

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   Vol. 42 ( 6 ) page: E643 - E647   2021.7

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    OBJECTIVES: To investigate the clinical features of ears with dilatation of the endolymphatic space in the ampulla of the posterior semicircular canal on magnetic resonance imaging. STUDY DESIGN: Retrospective study. SETTING: A university hospital. METHODS: This study included 1,842 ears from 934 patients who underwent 3-T magnetic resonance imaging with gadolinium to investigate the presence of endolymphatic hydrops. Age, sex distribution, hearing thresholds on pure-tone audiometry, and vestibular symptoms were compared between cases of unilateral and bilateral dilatation of the endolymphatic space in the ampulla of the posterior semicircular canal. RESULTS: Forty-eight ears (17 men and 14 women; mean age 49.9 yrs) showed dilatation of the endolymphatic space in the ampulla of the posterior semicircular canal. Age and the rate of chronic sensorineural hearing loss were significantly higher in the unilateral group (14 ears) than in the bilateral group (34 ears). The average hearing thresholds and rates of vestibular symptoms reported did not differ between unilateral and bilateral cases, but some patients showed positional nystagmus. CONCLUSIONS: Dilatation of the endolymphatic space in the ampulla was observed selectively in the posterior semicircular canal, though its pathogenesis was not clear. Such dilatation is not usually accompanied by vestibular endolymphatic hydrops, and it may be a cause of vertigo and dizziness.

    DOI: 10.1097/MAO.0000000000003073

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  180. 【COVID-19肺炎と肺疾患AI開発のフロントライン】COVID-19肺炎におけるAI研究の動向および問題点について Reviewed

    伊藤 倫太郎, 岩野 信吾, 長縄 慎二

    医用画像情報学会雑誌   Vol. 38 ( 2 ) page: 32 - 40   2021.7

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    COVID-19が世界中に広まり、COVID-19肺炎の診断に胸部CTや胸部単純X線の有用性が報告され、この画像所見を用いたAI開発が初期の段階から積極的に行われた。高性能なAIが多数存在するが、臨床において用いる際には注意すべき点が複数存在する。COVID-19肺炎に対して開発・使用された画像診断に関連するAI研究について、PubMedに2020年12月までに登録されたものを抽出しレビューを行った。

  181. Novel Magnetic Resonance Imaging-Based Method for Accurate Diagnosis of Meniere's Disease Reviewed

    Taeko Ito, Takashi Inoue, Hiroshi Inui, Toshiteru Miyasaka, Toshiaki Yamanaka, Kimihiko Kichikawa, Noriaki Takeda, Masato Kasahara, Tadashi Kitahara, Shinji Naganawa

    Frontiers in Surgery   Vol. 8   page: 671624   2021.6

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    Background: Pathologically, Meniere's disease symptoms are considered to be associated with endolymphatic hydrops. Examinations revealing endolymphatic hydrops can be useful for accurate Meniere's disease diagnosis. We previously reported a quantitative method for evaluating endolymphatic hydrops, i.e., by measuring the volume of the endolymphatic space using three-dimensional magnetic resonance imaging (MRI) of the inner ear. This study aimed to confirm the usefulness of our methods for diagnosing Meniere's disease. Here, we extracted new explanatory factors for diagnosing Meniere's disease by comparing the volume of the endolymphatic space between healthy volunteers and patients with Meniere's disease. Additionally, we validated our method by comparing its diagnostic accuracy with that of the conventional method.

    Methods and Findings: This is a prospective diagnostic accuracy study performed at vertigo/dizziness centre of our university hospital, a tertiary hospital. Eighty-six patients with definite unilateral Meniere's disease and 47 healthy volunteers (25 and 33 males, and 22 and 53 females in the control and patient groups, respectively) were enrolled. All participants underwent 3-Tesla MRI 4 h after intravenous injection of gadolinium to reveal the endolymphatic space. The volume of the endolymphatic space was measured and a model for Meniere's disease diagnosis was constructed and compared with models using conventional criteria to confirm the effectiveness of the methods used. The area under the receiver operating characteristic curve of the method proposed in this study was excellent (0.924), and significantly higher than that derived using the conventional criteria (0.877). The four indices, sensitivity, specificity, positive predictive value, and negative predictive value, were given at the threshold; all of these indices achieved higher scores for the 3D model compared to the 2D model. Cross-validation of the models revealed that the improvement was due to the incorporation of the semi-circular canals.

    Conclusions: Our method showed high diagnostic accuracy for Meniere's disease. Additionally, we revealed the importance of observing the semi-circular canals for Meniere's disease diagnosis. The proposed method can contribute toward providing effective symptomatic relief in Meniere's disease.

    DOI: 10.3389/fsurg.2021.671624

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  182. Age estimates from brain magnetic resonance images of children younger than two years of age using deep learning. Reviewed International journal

    Masahiro Kawaguchi, Hiroyuki Kidokoro, Rintaro Ito, Anna Shiraki, Takeshi Suzuki, Yuki Maki, Masaharu Tanaka, Yoko Sakaguchi, Hiroyuki Yamamoto, Yosiyuki Takahashi, Shinji Naganawa, Jun Natsume

    Magnetic resonance imaging   Vol. 79   page: 38 - 44   2021.6

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    The accuracy of brain age estimates from magnetic resonance (MR) images has improved with the advent of deep learning artificial intelligence (AI) models. However, most previous studies on predicting age emphasized aging from childhood to adulthood and old age, and few studies have focused on early brain development in children younger than 2 years of age. Here, we performed brain age estimates based on MR images in children younger than 2 years of age using deep learning. Our AI model, developed with one slice each of raw T1- and T2-weighted images from each subject, estimated brain age with a mean absolute error of 8.2 weeks (1.9 months). The estimates of our AI model were close to those of human specialists. The AI model also estimated the brain age of subjects with a myelination delay as significantly younger than the chronological age. These results indicate that the prediction accuracy of our AI model approached that of human specialists and that our simple method requiring less data and preprocessing facilitates a radiological assessment of brain development, such as monitoring maturational changes in myelination.

    DOI: 10.1016/j.mri.2021.03.004

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  183. Dosimetric impacts of beam-hardening filter removal for the CyberKnife system Reviewed International journal

    Takeshi Kamomae, Takuma Matsunaga, Junji Suzuki, Kuniyasu Okudaira, Fumitaka Kawabata, Yutaka Kato, Hiroshi Oguchi, Morihito Shimizu, Motoharu Sasaki, Yuki Takase, Mariko Kawamura, Kazuhiro Ohtakara, Yoshiyuki Itoh, Shinji Naganawa

    PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS   Vol. 86   page: 98 - 105   2021.6

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    Purpose: Equipment refurbishment was performed to remove the beam-hardening filter (BHF) from the CyberKnife system (CK). This study aimed to confirm the change in the beam characteristics between the conventional CK (present-BHF CK) and CK after the BHF was removed (absent-BHF CK) and evaluate the impact of BHF removal on the beam quality correction factors kQ. Methods: The experimental measurements of the beam characteristics of the present- and absent-BHF CKs were compared. The CKs were modeled using Monte Carlo simulations (MCs). The energy fluence spectra were calculated using MCs. Finally, kQ were estimated by combining the MC results and analytic calculations based on the TRS-398 and TRS-483 approaches. Results: All gamma values for percent depth doses and beam profiles between each CK were less than 0.5 following the 3%/1 mm criteria. The percentage differences for tissue-phantom ratios at depths of 20 and 10 cm and percentage depth doses at 10 cm between each CK were -1.20% and -0.97%, respectively. The MC results demonstrated that the photon energy fluence spectrum of the absent-BHF CK was softer than that of the presentBHF CK. The kQ values for the absent-BHF CK were in agreement within 0.02% with those for the present-BHF CK. Conclusions: The photon energy fluence spectrum was softened by the removal of BHF. However, no remarkable impact was observed for the measured beam characteristics and kQ. Therefore, the previous findings of the kQ values for the present-BHF CK can be directly used for the absent-BHF CK.

    DOI: 10.1016/j.ejmp.2021.05.011

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  184. Age-related changes in the distribution of intravenously administered gadolinium-based contrast agents leaked into the cerebrospinal fluid in patients with suspected endolymphatic hydrops Reviewed

    Toshio Ohashi, Shinji Naganawa, Saeko Iwata, Kayao Kuno

    Japanese Journal of Radiology   Vol. 39 ( 5 ) page: 433 - 441   2021.5

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    Purpose: The purpose of this retrospective study was to investigate the relationship between age and leakage of intravenously administered gadolinium-based contrast agents (GBCAs) into the cerebrospinal fluid (CSF) by volumetric segmentation of the whole-cranium CSF. Materials and methods: In 30 patients clinically diagnosed with suspected endolymphatic hydrops, the three-dimensional real inversion recovery (3D-real IR) images were obtained at pre- and 4 h post-intravenous administration of a single dose of GBCA. The volume of interest was set on the whole-cranium CSF in the 3D-real IR image. The signal intensity (SI)-increase of the ventricular CSF and the extra-ventricular CSF at 4 h post-administration of GBCA compared to pre-administration was measured. The relationship between the age of the patient and the SI-increase was evaluated. Results: A correlation between age and the SI-increase was observed in the whole-cranium CSF. The correlation coefficient between age and the SI-increase in the ventricular CSF was higher than that in the extra-ventricular CSF. Conclusion: An age-related leakage of the intravenously administered GBCAs was found in the whole-brain CSF. The age-related change in the distribution of the GBCA leakage was more prominent in the ventricular CSF than in the extra-ventricular CSF.

    DOI: 10.1007/s11604-020-01079-0

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  185. Early glottic cancer treatment with concurrent chemoradiotherapy with once-daily orally administered S-1 Reviewed

    Yuuki Takase, Yoshiyuki Itoh, Kazuhiro Ohtakara, Mariko Kawamura, Junji Ito, Yumi Oie, Tamami Ono, Yutaro Sasaki, Ayumi Nishida, Shinji Naganawa

    Nagoya Journal of Medical Science   Vol. 83 ( 2 ) page: 251 - 258   2021.5

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    Glottic carcinoma is the most common laryngeal cancer. The outcomes for T1 bulky Glottic carcinoma and T2N0 Glottic carcinoma after radiation therapy alone are unsatisfactory. This study was conducted to evaluate the efficacy and safety of unique concurrent chemoradiotherapy regimen using S-1 for early glottic cancer. Concurrent chemoradiotherapy consisted of 60 Gy in 30 fractions with once-daily, orally administered S-1 exclusively within three to six hours prior to each irradiation. Twenty-one consecutive patients treated with this regimen were retrospectively reviewed. Initial complete remission was achieved in all patients without any subsequent local and/or regional recurrences to the last follow-up. The 4-year local control, overall survival, and disease-free survival rates were all 100%. No significant toxicities were observed, except for three cases with Grade 3 acute dermatitis. This regimen is highly effective and well-tolerated, and these results encourage further research to long-term efficacy and functional preservation.

    DOI: 10.18999/nagjms.83.2.251

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  186. Diffusion analysis of fluid dynamics with incremental strength of motion proving gradient (DANDYISM) to evaluate cerebrospinal fluid dynamics Reviewed

    Toshiaki Taoka, Hisashi Kawai, Toshiki Nakane, Takashi Abe, Rei Nakamichi, Rintaro Ito, Yuki Sato, Mayuko Sakai, Shinji Naganawa

    Japanese Journal of Radiology   Vol. 39 ( 4 ) page: 315 - 323   2021.4

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    <title>Abstract</title><sec>
    <title>Purpose</title>
    To visualize and analyze the dynamics of cerebrospinal fluid (CSF) motion in the cranium, we evaluated the distribution of motion-related signal dephasing by CSF on Diffusion ANalysis of fluid DYnamics with Incremental Strength of Motion proving gradient (DANDYISM) method, a composite imaging method using various low <italic>b</italic> values.



    </sec><sec>
    <title>Materials and methods</title>
    This study examined ten subjects aged 25–58. We acquired DWIs on a 3T clinical scanner with <italic>b</italic> values 0, 50, 100, 200, 300, 500, 700, and 1000 s/mm<sup>2</sup> in total imaging time of 4 min. We constructed DANDYISM images and evaluated the CSF area distribution with decreased motion-dephasing signal using a scoring method.


    </sec><sec>
    <title>Results</title>
    The DANDYISM images showed statistically significant higher CSF scores in the ventral posterior fossa, suprasellar cistern, and Sylvian vallecula compared to the lateral ventricle and frontal and parietal CSF spaces, indicating greater CSF movement in the former areas.


    </sec><sec>
    <title>Conclusion</title>
    The results indicated prominent CSF motions in the ventral portion of the posterior fossa, suprasellar cistern, and Sylvian fissure but smaller motions in the lateral ventricles and parietal subarachnoid space. This method may provide information of CSF dynamics in the clinical settings within short imaging time.


    </sec>

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    Other Link: http://link.springer.com/article/10.1007/s11604-020-01075-4/fulltext.html

  187. Variation in thyroid volumes due to differences in the measured length or area of the cross-sectional plane: A validation study of the ellipsoid approximation method using CT images Reviewed

    Naotoshi Fujita, Katsuhiko Kato, Shinji Abe, Shinji Naganawa

    Journal of Applied Clinical Medical Physics   Vol. 22 ( 4 ) page: 15 - 25   2021.4

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    Purpose: This study examined the variation in the thyroid volume determined by the ellipsoid approximation method due to differences in the measured length or area of the cross-sectional plane of CT images. Methods: Forty-five patients with Graves' disease were included in this retrospective study. We designated the three-dimensional thyroid volumes extracted manually (VCT) as the reference data and calculated five approximate volumes for comparison: (a) the mean volume of 8100 different thyroid volumes depending on the diameter of the cross-sectional plane at the midpoint of the major axis, (Vellipsoid,mean)
    (b) the volume using the maximum diameter and its orthogonal diameter, (Vellipsoid,maxlength)
    (c) the maximum (Vellipsoid,maxvolume)
    (d) minimum (Vellipsoid,minvolume) of the 8100 thyroid volumes
    and (e) the volume determined with an equivalent circle diameter, (Vellipsoid,Heywood). Results: Thyroid volumes obtained via the ellipsoid approximation method varied depending on the diameter of the cross-sectional plane and included a mean error of approximately 20%, while the concordance correlation coefficient (CCC) differed for each approximate volume. Among these volumes, Vellipsoid,mean and Vellipsoid,Heywood were in good agreement with VCT, according to single regression analyses and the resultant CCC values, with mean errors of 0.1% and 10.4%, respectively. Conclusion: While Vellipsoid,Heywood approximated thyroid volumes with vastly reduced errors, we recommend utilizing three-dimensional thyroid volumetry if measurement accuracy is required.

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  188. 【Precision Medicine時代のCardiac Imaging 2021 後編】MRI:循環器領域における臨床の最前線と技術の到達点 MRIの技術革新が広げる循環器画像診断の可能性 大血管の4D flow MRI Reviewed

    櫻井 康雄, 竹原 康雄, 水野 崇, 阿部 真治, 長縄 慎二

    INNERVISION   Vol. 36 ( 5 ) page: 7 - 9   2021.4

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    MRIは、周辺技術の進歩により高画質、高速化が進められ、画像診断において重要な位置を占めている。MRによる生体内情報として、各組織のプロトンの密度、T1緩和、T2緩和、磁化率、拡散、血流、体液の流れ、灌流情報などの画像化、代謝情報が得られるが、その中で、血流や体液の流速を計測する試みは、位相コントラスト法を用いて古くから行われてきた。本稿では、血管領域に関する機能画像として、研究段階ではあるが、三次元の空間に時間軸情報を加えた三次元シネ位相コントラスト(phase contrast:PC)法である「4D flow MRI」について、主として大血管における現状を紹介する。(著者抄録)

  189. Time-resolved 3D cine phase-contrast magnetic resonance imaging (4D-flow MRI) can quantitatively assess portosystemic shunt severity and confirm normalization of portal flow after embolization of large portosystemic shunts. Reviewed International journal

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yoji Ishizu, Masataka Sugiyama, Shinji Naganawa

    Hepatology research : the official journal of the Japan Society of Hepatology   Vol. 51 ( 3 ) page: 343 - 349   2021.3

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    Diagnosis and severity assessments of portosystemic shunts (PSSs) are important because the pathology sometimes results in severe hepatic encephalopathy, which can be treated almost completely by shunt embolization. At present, morphological assessment of PSS is performed mainly by computed tomography, and ultrasound is used for blood flow assessment. In two cases of PSS-related hepatic encephalopathy, we used time-resolved 3D cine phase-contrast (4D-flow) magnetic resonance imaging (MRI) to assess blood flow before and after shunt embolization. Before the intervention, blood flow in the main trunk of the superior mesenteric vein was mostly hepatofugal. However, post-interventional 4D-flow MRI revealed hepatopetal superior mesenteric vein flow with significantly increased portal vein blood flow. 4D-flow MRI is an ideal adjunct to Doppler ultrasonography, allowing for objective and visual assessment of morphology and blood flow of the portal venous system, including PSSs, and is useful in determining the indications for, and outcome of, PSS embolization.

    DOI: 10.1111/hepr.13616

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  190. MRによる頭蓋内間質液・脳脊髄液動態の解明 Invited Reviewed

    長縄慎二、田岡俊昭、川井 恒

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成   Vol. - ( - ) page: 23 - 23   2021.3

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  191. TGSE-Radial Sampling型DWIにおける自作ファントムを用いたADC値と磁化率歪みの評価 Reviewed

    加藤 裕, 熊谷 始紀, 奥平 訓康, 丸山 克也, 田岡 俊昭, 長縄 慎二

    日本放射線技術学会総会学術大会予稿集   Vol. 77回   page: 200 - 200   2021.3

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  192. Imaging of endolymphatic hydrops on a vertigo attack of Meniere's disease. Reviewed

    Takafumi Nakada, Masaaki Teranishi, Saiko Sugiura, Yasue Uchida, Shinji Naganawa, Michihiko Sone

    Nagoya journal of medical science   Vol. 83 ( 1 ) page: 209 - 216   2021.2

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    Meniere's disease (MD) characteristically presents with endolymphatic hydrops (EH), which can be visualized with gadolinium-enhanced inner ear magnetic resonance imaging (MRI). Inner ear membrane rupture has been suspected to cause MD attacks, but this remains controversial. We report a case of MD coincidentally evaluated the EH using 3-Tesla MRI during a vertigo attack. A 78-year-old man with bilateral definite MD visited the hospital outpatient department due to a vertigo attack. To evaluate of endolymphatic hydrops on the attack, inner ear MRI was obtained 4 hours after intravenous injection of gadolinium agent. Vestibular EH in each ear occupied almost all vestibular endolymphatic space in contact with the oval window and herniated into the horizontal semi-circular canal. The endolymphatic space was enlarged, without collapse or mixture of contrast agent. No difference was found between ears. EH on a vertigo attack was associated with significant swelling, without obvious evidence of membranous ruptures on magnetic resonance images.

    DOI: 10.18999/nagjms.83.1.209

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  193. コロナウイルス肺炎のAi診断 Invited Reviewed

    伊藤倫太郎、岩野信吾、長縄慎二

    臨床免疫・アレルギー科   Vol. 75 ( 2 ) page: 189 - 193   2021.2

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  194. Iodine-related attenuation in contrast-enhanced dual-energy computed tomography in small-sized solid-type lung cancers is associated with the postoperative prognosis. Reviewed International journal

    Shingo Iwano, Shinichiro Kamiya, Rintaro Ito, Shota Nakamura, Shinji Naganawa

    Cancer imaging : the official publication of the International Cancer Imaging Society   Vol. 21 ( 1 ) page: 7 - 7   2021.1

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    BACKGROUND: To investigate the correlation between iodine-related attenuation in contrast-enhanced dual-energy computed tomography (DE-CT) and the postoperative prognosis of surgically resected solid-type small-sized lung cancers. METHODS: We retrospectively reviewed the DE-CT findings and postoperative course of solid-type lung cancers ≤3 cm in diameter. After injection of iodinated contrast media, arterial phases were scanned using 140-kVp and 80-kVp tube voltages. Three-dimensional iodine-related attenuation (3D-IRA) of primary tumors at the arterial phase was computed using the "lung nodule" application software. The corrected 3D-IRA normalized to the patient's body weight and contrast medium concentration was then calculated. RESULTS: A total of 120 resected solid-type lung cancers ≤3 cm in diameter were selected for analysis (82 males and 38 females; mean age, 67 years). During the observation period (median, 47 months), 32 patients showed postoperative recurrence. Recurrent tumors had significantly lower 3D-IRA and corrected 3D-IRA at early phase compared to non-recurrent tumors (p = 0.046 and p = 0.027, respectively). The area under the receiver operating characteristic curve for postoperative recurrence was 0.624 for the corrected 3D-IRA at early phase (p = 0.025), and the cutoff value was 5.88. Kaplan-Meier curves for disease-free survival indicated that patients showing tumors with 3D-IRA > 5.88 had a significantly better prognosis than those with tumors showing 3D-IRA < 5.88 (p = 0.017). CONCLUSIONS: The 3D-IRA of small-sized solid-type lung cancers on contrast-enhanced DE-CT was significantly associated with postoperative prognosis, and low 3D-IRA tumors showed a higher TNM stage and a significantly poorer prognosis.

    DOI: 10.1186/s40644-020-00368-1

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  195. Lesion-specific prognosis by magnetic resonance imaging in sudden sensorineural hearing loss. Reviewed International journal

    Cheng-Jui Yang, Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Masumi Kobayashi, Naoki Nishio, Shinji Naganawa, Michihiko Sone

    Acta oto-laryngologica   Vol. 141 ( 1 ) page: 5 - 9   2021.1

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    BACKGROUND: High signals in the inner ear of idiopathic sudden sensorineural hearing loss (ISSNHL) on magnetic resonance imaging (MRI) have been reported, but no quantitative evaluation has yet been done. OBJECTIVES: To evaluate hearing outcomes and cochlear signal intensities on 3-T heavily T2-weighted three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (hT2W-3D-FLAIR) in patients with ISSNHL. MATERIALS AND METHODS: Twenty-nine patients with ISSNHL were included. Patients underwent hT2W-3D-FLAIR with intravenous gadolinium injection and pure tone audiometry (PTA) at initial visits and 3 months later. Signal intensity ratios (SIRs) were measured in the basal or apical-middle turns of the affected cochlea. A statistical analysis of relationships between SIRs and the average hearing levels (HLs) at low (125, 250, and 500 Hz) and high (2, 4, and 8 kHz) tone frequencies was performed. RESULTS: Hearing improvements at high-tone frequencies in ears with HLs ≥60 dB were significantly worse in those with high SIRs at the basal turns on pre-contrast images. Similarly, hearing improvements at low-tone frequencies in ears with HLs ≥60 dB were significantly worse in those with high SIRs at the apical-middle turns on post-contrast images. CONCLUSIONS AND SIGNIFICANCE: High SIRs on hT2W-3D-FLAIR indicate cochlear disturbances with severe ISSNHL and could provide lesion-specific prognostic information.

    DOI: 10.1080/00016489.2020.1827159

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  196. Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics. Reviewed

    Toshiaki Taoka, Shinji Naganawa

    Japanese journal of radiology   Vol. 39 ( 1 ) page: 1 - 14   2021.1

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    After the introduction of the glymphatic system hypothesis, an increasing number of studies on cerebrospinal fluid and interstitial fluid dynamics within the brain have been investigated and reported. A series of diseases are known which develop due to abnormality of the glymphatic system including Alzheimer's disease, traumatic brain injury, stroke, or other disorders. These diseases or disorders share the characteristics of the glymphatic system dysfunction or other mechanisms related to the interstitial fluid dynamics. In this review article, we propose "Central Nervous System (CNS) Interstitial Fluidopathy" as a new concept encompassing diseases whose pathologies are majorly associated with abnormal interstitial fluid dynamics. Categorizing these diseases or disorders as "CNS interstitial fluidopathies," will promote the understanding of their mechanisms and the development of potential imaging methods for the evaluation of the disease as well as clinical methods for disease treatment or prevention. In other words, having a viewpoint of the dynamics of interstitial fluid appears relevant for understanding CNS diseases or disorders, and it would be possible to develop novel common treatment methods or medications for "CNS interstitial fluidopathies."

    DOI: 10.1007/s11604-020-01017-0

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  197. Distribution of gadolinium-based contrast agent after leaking into the cerebrospinal fluid: Comparison between the cerebral cisterns and the lateral ventricles Reviewed

    Toshio Ohashi, Shinji Naganawa, Saeko Iwata, Kayao Kuno

    Magnetic Resonance in Medical Sciences   Vol. 20 ( 2 ) page: 175 - 181   2021

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    Purpose: Leakage of a small amount of intravenously administered gadolinium-based contrast agents (GBCAs) into the cerebrospinal fluid (CSF) space has been reported, even in healthy subjects without blood-brain barrier disruption. Several candidates including the choroid plexus and cortical veins have been proposed as the source of the leakage. The purpose of this study was to evaluate the distribution of intravenously administered GBCA leakage into the CSF by comparing the contrast enhancement of the cerebral cisterns to the lateral ventricles (LVs). Methods: In 26 patients with a suspicion of endolymphatic hydrops (21-80 years old), a three-dimensional real inversion recovery (3D-real IR) image was obtained at pre-, and at 5 min, and 4 h post-intravenous administration of a single dose of GBCA (IV-SD-GBCA). In the 3D-real IR image, the signal intensities (SIs) in the anterior horn of the LV (LVante), the trigone of the LV (LVtri), the Sylvian fissure (SyF), the ambient cistern (Amb), the prepontine cistern (PPC), the cerebellopontine angle cistern (CPA), and the vitreous (Vit) were measured. The differences in the SI at pre-, and at 5 min and 4 h post-IV-SD-GBCA were evaluated for each region. The change in the SI pre- to post-IV-SD-GBCA (SIchange) were calculated for each region. The differences in the SIchange in each region were evaluated at 5 min and 4 h post-IV-SD-GBCA. A Steel-Dwass’s test was applied to correct for multiple comparisons. Results: The SIs of all regions at 4 h post-IV-SD-GBCA were significantly higher compared with pre-IV-SD-GBCA (P &lt
    0.05). The SIchange in the SyF, Amb, PPC, and the CPA were significantly higher compared with those of the LVante, LVtri, and the Vit at 4 h post-IV-SD-GBCA (P &lt
    0.05). Conclusion: The contrast enhancement in the cerebral cisterns was greater than that in the LVs.

    DOI: 10.2463/mrms.mp.2020-0016

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  198. Three Dimensional Ultra-short Echo Time MRI Can Depict Cholesterol Components of Gallstones Bright. Reviewed

    Mamoru Takahashi, Yasuo Takehara, Kenji Fujisaki, Tomoyuki Okuaki, Yukiko Fukuma, Norihiro Tooyama, Katsutoshi Ichijo, Tomoyasu Amano, Satoshi Goshima, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 4 ) page: 359 - 370   2021

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    PURPOSE: Non-calcified cholesterol stones that are small in size are hard to be depicted on CT or magnetic resonance cholangiopancreatography. This institutional review board (IRB)-approved retrospective in vitro study aims to characterize contrast behaviors of 3 main components of the gallstones, i.e., cholesterol component (CC), bilirubin calcium component (BC) and CaCO3 (CO) on 3D radial scan with ultrashort TE (UTE) MRI, and to test the capability of depicting CC of gallstones as bright signals as compared to background saline. METHODS: Fourteen representative gallstones from 14 patients, including 15 CC, 6 BC and 4 CO, were enrolled. The gallstones underwent MRI including fat-saturated T1-weighted image (fs-T1WI) and UTE MRI with dual echoes. The contrast-to-noise ratio (CNR) and the chemical analysis for the 25 portions of the stones were compared. RESULTS: BC was bright on fs-T1WI, which did not change dramatically on UTE MRI and the signal did not remain on UTE subtraction image between dual echoes. Whereas the CC was negative or faintly positive signal on fs-T1WI, bright signal on UTE MRI and the contrast remained even higher on the UTE subtraction, which reflected their short T2 values. Median CNRs and standard errors of the segments on each imaging were as follows: on fs-T1WI, -10.2 ± 4.2 for CC, 149.7 ± 27.6 for BC and 37.9 ± 14.3 for CO; on UTE MRI first echo, 16.7 ± 3.3 for CC, 74.9 ± 21.3 for BC and 17.7 ± 8.4 for CO; on UTE subtraction image, 30.2 ±2.0 for CC, -11.2 ± 5.4 for BC and 17.8 ± 10.7 for CO. Linear correlations between CNRs and cholesterol concentrations were observed on fs-T1WI with r = -0.885, (P < 0.0001), UTE MRI first echo r = -0.524 (P = 0.0072) and UTE subtraction with r = 0.598 (P = 0.0016). CONCLUSION: UTE MRI and UTE subtraction can depict CC bright.

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  199. Relationship between Time-dependent Signal Changes in Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space. Reviewed

    Shinji Naganawa, Rintaro Ito, Rei Nakamichi, Mariko Kawamura, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 4 ) page: 378 - 384   2021

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    PURPOSE: To investigate the association between signal changes over time in perivenous cystic structures near the superior sagittal sinus and leakage of a gadolinium-based contrast agent (GBCA) into the subarachnoid space in patients with suspected endolymphatic hydrops. METHODS: Fifty-one cystic structures in 27 cases were evaluated. The signal intensity of the cystic structures was measured on 3D real inversion recovery (3D-real IR) images obtained at pre-, and at 10 min, 4 hrs and 24 hrs post-intravenous administration (IV) of GBCA. Signal enhancement of the cystic structures from the pre-contrast images at each time point was compared in subjects with leakage (positive) versus those without leakage (negative) using an ANOVA. Fisher's exact probability test was used to compare the maximum contrast-enhanced time point between positive and negative groups. We used 5% as a threshold to determine statistical significance. RESULTS: In leakage positive subjects, mean signal enhancement of the cysts was significantly greater at 4 and 24 hrs compared to 10 min. However, although there was a trend of an increase from 4 to 24 hrs, the difference was not significant. In the leakage negative group, mean signal enhancement of the cysts was significantly higher at 4 hrs compared to 10 min and 24 hrs. There was no significant difference between 10 min and 24 hrs. In the positive group, the maximum signal increase was found in 10/38 and 28/38 cysts at 4 and 24 hrs after IV-GBCA, respectively. In the leakage negative group, the maximum signal increase was found in 10/13 and 3/13 cysts at 4 and 24 hrs, respectively (P = 0.0019). CONCLUSION: There was an association between signal changes over time after IV-GBCA in perivenous cystic structures and leakage of GBCA. Further research to clarify the impact of cystic structures on the function of the waste clearance system of the brain is warranted.

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  200. Relationship between Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space around the Cortical Veins after Intravenous Administration. Reviewed

    Shinji Naganawa, Rintaro Ito, Rei Nakamichi, Mariko Kawamura, Hisashi Kawai, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 3 ) page: 245 - 252   2021

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    PURPOSE: The purpose of this retrospective study was to investigate the relationship between the number and size of cystic structures around the cortical veins near the superior sagittal sinus and the leakage of gadolinium-based contrast agent (GBCA) around the cortical veins. METHODS: Of 190 patients (91 male and 99 female), that were scanned at 4 h after an intravenous injection of GBCA as a diagnostic examination for endolymphatic hydrops, 6 patients with GBCA leakage were younger than the previously proposed threshold age of 37.3 years for leakage. Six age-matched patients without leakage were also included for reference. In addition, we included 8 cases without leakage that were older than the hypothesized threshold of 37.3 years, as well as 8 age-matched patients with GBCA leakage into the cerebrospinal fluid space. The number of cysts was counted and the sizes were measured in these 28 patients (age: 32-60 years old, 13 men and 15 women). RESULTS: The mean number of cysts surrounding the cortical veins in the parasagittal region was 4.29 ± 1.77 vs. 1.79 ± 1.05 (P = 0.0001) in the subjects with and without GBCA leakage, respectively. The mean size of the largest cysts was at 8.89 ± 3.49 mm vs. 5.69 ± 2.29 (P = 0.009) in the subjects with and without GBCA leakage, respectively. CONCLUSION: The number and size of the perivenous cystic structures near the superior sagittal sinus is greater in subjects with GBCA leakage into the subarachnoid space compared with those without leakage. Future research regarding the histological and functional details of these parasagittal cystic structures is needed.

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  201. Portal Vein Stenosis Following Liver Transplantation Hemodynamically Assessed with 4D-flow MRI before and after Portal Vein Stenting. Reviewed

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yasuhiro Ogura, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 3 ) page: 231 - 235   2021

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    We present a case of a patient who underwent portal vein (PV) stenting for PV stenosis after a living-donor liver transplantation. A pretreatment 3D cine phase-contrast (4D-flow) MRI showed decreased, though hepatopetal, blood flow in the PV. After stenting, 4D-flow MRI confirmed an improvement in PV flow, with a more homogeneous flow distribution to each hepatic segment. 4D-flow MRI are valuable for understanding the hemodynamics of this area, planning for treatments, and evaluating the outcome of the interventions.

    DOI: 10.2463/mrms.ici.2020-0057

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  202. MR Imaging of Endolymphatic Hydrops: Utility of iHYDROPS-Mi2 Combined with Deep Learning Reconstruction Denoising. Reviewed

    Shinji Naganawa, Rei Nakamichi, Kazushige Ichikawa, Mariko Kawamura, Hisashi Kawai, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 3 ) page: 272 - 279   2021

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    PURPOSE: MRI of endolymphatic hydrops (EH) 4 h after intravenous administration of a single dose of gadolinium-based contrast agent is used for clinical examination in some institutions; however, further improvement in image quality would be valuable for wider clinical utility. Denoising using deep learning reconstruction (Advanced Intelligent Clear-IQ Engine [AiCE]) has been reported for CT and MR. The purpose of this study was to compare the contrast-to-noise ratio of endolymph to perilymph (CNREP) between the improved hybrid of reversed image of the positive endolymph signal and the native image of the perilymph signal multiplied with the heavily T2-weighted MR cisternography (iHYDROPS-Mi2) images, which used AiCE for the three source images (i.e. positive endolymph image [PEI], positive perilymph image [PPI], MR cisternography [MRC]) to those that did not use AiCE. We also examined if there was a difference between iHYDROPS-Mi2 images with and without AiCE for degree of visual grading of EH and in endolymphatic area [EL] ratios. METHODS: Nine patients with suspicion of EH were imaged on a 3T MR scanner. iHYDROPS images were generated by subtraction of PEI images from PPI images. iHYDROPS-Mi2 images were then generated by multiplying MRC with iHYDROPS images. The CNREP and EL ratio were measured on the iHYDROPS-Mi2 images. Degree of radiologist visual grading for EH was evaluated. RESULTS: Mean CNREP ± standard deviation was 1681.8 ± 845.2 without AiCE and 7738.6 ± 5149.2 with AiCE (P = 0.00002). There was no significant difference in EL ratio for images with and without AiCE. Radiologist grading for EH agreed completely between the 2 image types in both the cochlea and vestibule. CONCLUSION: The CNREP of iHYDROPS-Mi2 images with AiCE had more than a fourfold increase compared with that without AiCE. Use of AiCE did not adversely affect radiologist grading of EH.

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  203. Intracranial Distribution of Intravenously Administered Gadolinium-based Contrast Agent over a Period of 24 Hours: Evaluation with 3D-real IR Imaging and MR Fingerprinting. Reviewed

    Shinji Naganawa, Rintaro Ito, Yutaka Kato, Hisashi Kawai, Toshiaki Taoka, Tadao Yoshida, Katsuya Maruyama, Katsutoshi Murata, Gregor Körzdörfer, Josef Pfeuffer, Mathias Nittka, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 1 ) page: 91 - 98   2021

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    PURPOSE: To evaluate the feasibility for the detection of slight contrast effects after intravenous administration of single dose gadolinium-based contrast agent (IV-SD-GBCA), the time course of the GBCA distribution up to 24 h was examined in various fluid spaces and brain parenchyma using 3D-real IR imaging and MR fingerprinting (MRF). METHODS: Twenty-four patients with a suspicion of endolymphatic hydrops were scanned at pre-administration and at 10 min, 4 and 24 h post-IV-SD-GBCA. 3D-real IR images and MRF at the level of the internal auditory canal were obtained. The signal intensity on the 3D-real IR image of the cerebrospinal fluid (CSF) in the cerebellopontine angle cistern (CPA), Sylvian fissure (Syl), lateral ventricle (LV), and cochlear perilymph (CPL) was measured. The T1 and T2 values of cerebellar gray (GM) and white matter (WM) were measured using MRF. Each averaged value at the various time points was compared using an analysis of variance. RESULTS: The signal intensity on the 3D-real IR image in each CSF region peaked at 4 h, and was decreased significantly by 24 h (P< 0.05). All patients had a maximum signal intensity at 4 h in the CPA, and Syl. The mean CPL signal intensity peaked at 4 h and decreased significantly by 24 h (P < 0.05). All patients but two had a maximum signal intensity at 4 h. Regarding the T1 value in the cerebellar WM and GM, the T1 value at 10 min post-IV-GBCA was significantly decreased compared to the pre-contrast scan, but no significant difference was observed at the other time points. There was no significant change in T2 in the gray or white matter at any of the time points. CONCLUSION: Time course of GBCA after IV-SD-GBCA could be evaluated by 3D-real IR imaging in CSF spaces and in the brain by MRF.

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  204. 特集「世界の医療・Radiology:海外事情を覗き見よう」ドイツ編 Reviewed

    長縄慎二

    JCRニュース (日本放射線科専門医会・医会誌)   Vol. 238 ( - ) page: 11 - 13   2021

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  205. A case of stent-graft implantation for postpancreaticoduodenectomy hemorrhage in a patient with a reconstructed gastric tube Reviewed

    Tomohiro Komada, Yasushi Tachi, Ken Nagasaka, Suguru Yamada, Masaya Matsushima, Yutaro Sakaki, Shinji Naganawa

    Radiology Case Reports   Vol. 15 ( 12 ) page: 2710 - 2713   2020.12

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    DOI: 10.1016/j.radcr.2020.10.021

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  206. Evaluation of magnetic resonance angiography as a possible alternative to rotational angiography or computed tomography angiography for assessing cerebrovascular computational fluid dynamics. Reviewed International journal

    Yuya Yoneyama, Haruo Isoda, Kenta Ishiguro, Masaki Terada, Masaki Kamiya, Kenichi Otsubo, Roshani Perera, Takashi Mizuno, Atsushi Fukuyama, Kazuya Takiguchi, Tomoya Watanabe, Takafumi Kosugi, Yoshiaki Komori, Shinji Naganawa

    Physical and engineering sciences in medicine   Vol. 43 ( 4 ) page: 1327 - 1337   2020.12

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    The aim of this study was to conduct a flow experiment using a cerebrovascular phantom and investigate whether magnetic resonance angiography (MRA) could replace three-dimensional rotational angiography (RA) and computed tomography angiography (CTA) to construct vascular models for computational fluid dynamics (CFD). We performed MRA and 3D cine phase-contrast (PC) MR imaging with a silicone cerebrovascular phantom of an internal carotid artery-posterior communicating artery aneurysm with blood-mimicking fluid, and controlled flow with a flowmeter. We also obtained RA and CTA data for the phantom. Four analysts constructed vascular models based on the three different modalities. These 12 constructed models used flow information based on 3D cine PC MR imaging for CFD. We compared RA-, CTA-, MRA-based CFD results using the micro-CT-based CFD result as the criterion standard to investigate whether MRA-based CFD was not inferior to RA- or CTA-based CFD. We also analyzed the inter-analyst variability. Wall shear stress (WSS) distributions and streamlines of RA- or MRA-based CFD and those of micro-CT-based CFD were similar, but the vascular models and WSS values were different. Accuracy in measurements of blood vessel diameter, cross-sectional maximum velocity, and spatially averaged WSS was the highest for RA-based CFD, followed by MRA-based and CTA-based CFD using micro-CT-based CFD result as the reference. Except maximum velocity from CTA, all other parameters had good inter-analyst agreement using different modalities. The results demonstrated that non-invasive MRA can be used for cerebrovascular CFD models with good inter-analyst agreements.

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  207. 【基調論文】CTおよびMRIなどの画像診断装置の今後の展望 Reviewed

    長縄慎二

    月間新医療データブック・シリーズ 医療機器システム白書   Vol. - ( - ) page: 14 - 18   2020.12

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  208. 【特集】 マネジメントに苦慮する疾患: Is it benign, malignant or insignificant? 1. 甲状腺病変の診断とマネジメント Invited Reviewed

    石垣聡子、佐竹弘子、松本篤子、林 葉子、清水友理、長縄慎二

    日獨医報   Vol. 65 ( 1 ) page: 5 - 11   2020.12

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  209. Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio. Reviewed International journal

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Reiko Ohdake, Michihito Masuda, Aya Ogura, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

    NeuroImage   Vol. 222   page: 117241 - 117241   2020.11

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    Neuroimaging studies have shown that the brain is functionally organized into several large-scale brain networks. Within these networks are regions that are widely connected to several other regions within and/or outside the network. Regions that connect to several other networks, known as connector hubs, are believed to be crucial for information transfer and between-network communication within the brain. To identify regions with high between-network connectivity at the voxel level, we introduced a novel metric called functional connectivity overlap ratio (FCOR), which quantifies the spatial extent of a region's connection to a given network. Using resting state functional magnetic resonance imaging data, FCOR maps were generated for several well-known large-scale resting state networks (RSNs) and used to examine the relevant associations among different RSNs, identify connector hub regions in the cerebral cortex, and elucidate the hierarchical functional organization of the brain. Constructed FCOR maps revealed a strong association among the core neurocognitive networks (default mode, salience, and executive control) as well as among primary processing networks (sensorimotor, auditory, and visual). Prominent connector hubs were identified in the bilateral middle frontal gyrus, posterior cingulate, lateral parietal, middle temporal, dorsal anterior cingulate, and anterior insula, among others, regions mostly associated with the core neurocognitive networks. Finally, clustering the whole brain using FCOR features yielded a topological organization that arranges brain regions into a hierarchy of information processing systems with the primary processing systems at one end and the heteromodal systems comprising connector hubs at the other end.

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  210. Neurofluid Dynamics and the Glymphatic System: A Neuroimaging Perspective. Reviewed International journal

    Toshiaki Taoka, Shinji Naganawa

    Korean journal of radiology   Vol. 21 ( 11 ) page: 1199 - 1209   2020.11

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    The glymphatic system hypothesis is a concept describing the clearance of waste products from the brain. The term "glymphatic system" combines the glial and lymphatic systems and is typically described as follows. The perivascular space functions as a conduit that drains cerebrospinal fluid (CSF) into the brain parenchyma. CSF guided to the perivascular space around the arteries enters the interstitium of brain tissue via aquaporin-4 water channels to clear waste proteins into the perivascular space around the veins before being drained from the brain. In this review, we introduce the glymphatic system hypothesis and its association with fluid dynamics, sleep, and disease. We also discuss imaging methods to evaluate the glymphatic system.

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  211. Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks Reviewed International journal

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshiaki Taoka, Shuji Koyama, Hiroki C. Tanabe, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

    Frontiers in Aging Neuroscience   Vol. 12   page: 592469 - 592469   2020.10

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    Recent studies have demonstrated that connector hubs, regions considered critical for the flow of information across neural systems, are mostly involved in neurodegenerative dementia. Considering that aging can significantly affect the brain's intrinsic connectivity, identifying aging's impact on these regions' overall connection strength is important to differentiate changes associated with healthy aging from neurodegenerative disorders. Using resting state functional magnetic resonance imaging data from a carefully selected cohort of 175 healthy volunteers aging from 21 to 86 years old, we computed an intrinsic connectivity contrast (ICC) metric, which quantifies a region's overall connectivity strength, for whole brain, short-range, and long-range connections and examined age-related changes of this metric over the adult lifespan. We have identified a limited number of hub regions with ICC values that showed significant negative relationship with age. These include the medial precentral/midcingulate gyri and insula with both their short-range and long-range (and thus whole-brain) ICC values negatively associated with age, and the angular, middle frontal, and posterior cingulate gyri with their long-range ICC values mainly involved. Seed-based connectivity analyses further confirmed that these regions are connector hubs with connectivity profile that strongly overlapped with multiple large-scale brain networks. General cognitive performance was not associated with these hubs' ICC values. These findings suggest that even healthy aging could negatively impact the efficiency of regions critical for facilitating information transfer among different functional brain networks. The extent of the regions involved, however, was limited.

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  212. Significance of high signal intensity in the endolymphatic duct on magnetic resonance imaging in ears with otological disorders. Reviewed International journal

    Kyoko Morimoto, Tadao Yoshida, Masumi Kobayashi, Satofumi Sugimoto, Naoki Nishio, Masaaki Teranishi, Shinji Naganawa, Michihiko Sone

    Acta oto-laryngologica   Vol. 140 ( 10 ) page: 818 - 822   2020.10

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    BACKGROUND: High signal intensity in the endolymphatic duct (ED) is occasionally observed on magnetic resonance imaging (MRI) in ears that have otological disorders. OBJECTIVE: The signal intensity (SI) in the ED on post-contrast MRI was investigated in subjects with various otological disorders, and the meaning of high SI in the ED was evaluated. MATERIAL AND METHODS: 392 patients with otological disorders and 21 controls without otological symptoms underwent 3 T MRI. The SIs of the ED and the cerebellum were measured, the SI ratio (SIR) was calculated, and ears with SIR ≥4 were identified. RESULTS: A high SIR was identified in the ED of 3.7% of ears affected by definite Meniere's disease (dMD), 100% of ears affected by large vestibular aqueduct syndrome (LVAS), and 7.1% of ears with no otological symptoms. On the whole, a significant relationship was found between the existence of vestibular or cochlear EH and the SIR in the ED. CONCLUSION: The MRI finding of high SI in the ED may indicate the mechanism of inner ear disturbances in ears with otological disorders, especially in those with LVAS, and it may suggest an underlying disorder in some ears in which otological symptoms are not apparent.

    DOI: 10.1080/00016489.2020.1781927

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  213. Change of White Matter Integrity in Children With Hematopoietic Stem Cell Transplantation. Reviewed International journal

    Yoko Sakaguchi, Jun Natsume, Hiroyuki Kidokoro, Masaharu Tanaka, Yu Okai, Yuji Ito, Hiroyuki Yamamoto, Atsuko Ohno, Tomohiko Nakata, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Hideki Muramatsu, Shinji Naganawa, Yoshiyuki Takahashi

    Pediatric neurology   Vol. 111   page: 78 - 84   2020.10

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    BACKGROUND: Advances in hematopoietic stem cell transplantation have improved the survival rate of malignant diseases and congenital immunodeficiencies. It has become important to assess long-term complications in survivors. To assess neurological abnormalities in children treated by transplantation, diffusion tensor imaging was performed. METHODS: Forty children who underwent head diffusion tensor imaging before and after their first transplantation were enrolled. Patients with brain lesions on conventional MRI were excluded. Fractional anisotropy and mean diffusivity were compared between patients and 28 control subjects using tract-based spatial statistics. The Strengths and Difficulties Questionnaire was administered as a behavioral evaluation after transplantation, and diffusion tensor images of patients with and without behavioral abnormalities were compared. RESULTS: The age of patients and controls was 0 to 19 years and 0 to 16 years, respectively. The date of diffusion tensor imaging was 10 to 57 days before and 40 to 153 days after transplantation. Tract-based spatial statistics showed fractional anisotropy reduction in widespread white matter in patients before and after transplantation. Mean diffusivity was high before transplantation and normalized after transplantation. Analysis comparing before and after hematopoietic stem cell transplantation shows no difference in fractional anisotropy and a higher mean diffusivity before hematopoietic stem cell transplantation. In patients with behavioral abnormalities, low fractional anisotropy and high mean diffusivity remained after transplantation. CONCLUSIONS: Longitudinal diffusion tensor imaging showed white matter abnormalities in children without conventional MRI abnormalities, which were related to behavioral problems after transplantation. Diffusion tensor imaging is useful for behavioral assessment in children undergoing transplantation.

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  214. A review on the use of artificial intelligence for medical imaging of the lungs of patients with coronavirus disease 2019. Reviewed International journal

    Rintaro Ito, Shingo Iwano, Shinji Naganawa

    Diagnostic and interventional radiology (Ankara, Turkey)   Vol. 26 ( 5 ) page: 443 - 448   2020.9

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    The results of research on the use of artificial intelligence (AI) for medical imaging of the lungs of patients with coronavirus disease 2019 (COVID-19) has been published in various forms. In this study, we reviewed the AI for diagnostic imaging of COVID-19 pneumonia. PubMed, arXiv, medRxiv, and Google scholar were used to search for AI studies. There were 15 studies of COVID-19 that used AI for medical imaging. Of these, 11 studies used AI for computed tomography (CT) and 4 used AI for chest radiography. Eight studies presented independent test data, 5 used disclosed data, and 4 disclosed the AI source codes. The number of datasets ranged from 106 to 5941, with sensitivities ranging from 0.67-1.00 and specificities ranging from 0.81-1.00 for prediction of COVID-19 pneumonia. Four studies with independent test datasets showed a breakdown of the data ratio and reported prediction of COVID-19 pneumonia with sensitivity, specificity, and area under the curve (AUC). These 4 studies showed very high sensitivity, specificity, and AUC, in the range of 0.9-0.98, 0.91-0.96, and 0.96-0.99, respectively.

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  215. 第21回山形めまい研究会 特別講演Ⅰ MR imaging of endolymphatic hydrops; What is right, what is wrong, and what is new Invited Reviewed

    長縄慎二

    耳鼻咽喉科山形 (日本耳鼻咽喉科学会山形県地方部会誌)   Vol. 24 ( - ) page: 54 - 55   2020.9

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  216. Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis. Reviewed International journal

    Shao Wei Choy, Epifanio Bagarinao, Hirohisa Watanabe, Eric Tatt Wei Ho, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshiaki Taoka, Shuji Koyama, Hiroki C Tanabe, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

    Human brain mapping   Vol. 41 ( 12 ) page: 3198 - 3211   2020.8

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    White matter (WM) fiber bundles change dynamically with age. These changes could be driven by alterations in axonal diameter, axonal density, and myelin content. In this study, we applied a novel fixel-based analysis (FBA) framework to examine these changes throughout the adult lifespan. Using diffusion-weighted images from a cohort of 293 healthy volunteers (89 males/204 females) from ages 21 to 86 years old, we performed FBA to analyze age-related changes in microscopic fiber density (FD) and macroscopic fiber morphology (fiber cross section [FC]). Our results showed significant and widespread age-related alterations in FD and FC across the whole brain. Interestingly, some fiber bundles such as the anterior thalamic radiation, corpus callosum, and superior longitudinal fasciculus only showed significant negative relationship with age in FD values, but not in FC. On the other hand, some segments of the cerebello-thalamo-cortical pathway only showed significant negative relationship with age in FC, but not in FD. Analysis at the tract-level also showed that major fiber tract groups predominantly distributed in the frontal lobe (cingulum, forceps minor) exhibited greater vulnerability to the aging process than the others. Differences in FC and the combined measure of FD and cross section values observed between sexes were mostly driven by differences in brain sizes although male participants tended to exhibit steeper negative linear relationship with age in FD as compared to female participants. Overall, these findings provide further insights into the structural changes the brain's WM undergoes due to the aging process.

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  217. Efficacy and safety of accelerated fractionated radiotherapy without elective nodal irradiation for T3N0 glottic cancer without vocal cord fixation. Reviewed International journal

    Masayuki Okumura, Atsushi Motegi, Sadamoto Zenda, Naoki Nakamura, Hidehiro Hojo, Masaki Nakamura, Yasuhiro Hirano, Shun-Ichiro Kageyama, Satoko Arahira, Raturi Vijay Parshuram, Hirofumi Kuno, Ryuichi Hayashi, Makoto Tahara, Yoshiyuki Itoh, Shinji Naganawa, Tetsuo Akimoto

    Head & neck   Vol. 42 ( 8 ) page: 1775 - 1782   2020.8

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    BACKGROUND: The purpose of this study was to evaluate accelerated fractionated radiotherapy (AFRT) without elective nodal irradiation (ENI) for T3N0 glottic cancer (GC) without vocal cord fixation, especially in comparison with chemoradiotherapy (CRT) and hyperfractionated radiotherapy (HFRT) both of which included ENI. METHODS: The medical charts of patients with T3N0GC without cord fixation received definitive radiotherapy between June 2005 and March 2018 were reviewed. RESULTS: A total of 74 patients were analyzed. After a median follow-up time of 46 months (range, 12-141), 3-year local failure in AFRT/CRT/HFRT (n = 41/10/23) was 10%/20%/26%, 3-year regional failure 6%/0%/9%, 3-year progression-free survival 71%/69%/74%, and 3-year overall survival 77%/100%/87%. There were no significant differences among three groups in recurrence or survival. Grade 3 adverse events (AEs) were noted in 5/2/8 patients (12%/20%/35%) in AFRT/CRT/HFRT, respectively. There were no Grade 4/5 AEs. CONCLUSIONS: AFRT without ENI is an effective and feasible treatment for T3N0GC without cord fixation.

    DOI: 10.1002/hed.26092

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  218. ロボット支援前立腺全摘除術後の難治性乳び腹水に対してリンパ管塞栓術が奏功した一例 Reviewed

    兵藤 良太, 山田 恵一郎, 堀口 瞭太, 伊藤 準, 松島 正哉, 駒田 智大, 大脇 貴之, 竹原 康雄, 長縄 慎二

    日本インターベンショナルラジオロジー学会雑誌   Vol. 35 ( Suppl. ) page: 290 - 290   2020.8

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  219. Effects of endolymphatic hydrops on acoustic energy absorbance. Reviewed International journal

    Masumi Kobayashi, Tadao Yoshida, Satofumi Sugimoto, Mariko Shimono, Masaaki Teranishi, Shinji Naganawa, Michihiko Sone

    Acta oto-laryngologica   Vol. 140 ( 8 ) page: 626 - 631   2020.7

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    Background: The presence of endolymphatic hydrops (EH) may cause hearing loss and affect the transmission of acoustic energy to the inner ear.Objectives: Acoustic energy absorbance on wideband acoustic immittance (WAI) was evaluated, focusing especially on EH in the vestibule.Material and methods: A total of 32 ears from 16 patients who underwent 3-T magnetic resonance imaging (MRI) to evaluate the presence of EH were examined, retrospectively. The degree of EH in the vestibule was classified into three grades (no, mild, and significant), and pure tone audiometry (PTA) and WAI were measured before and after a glycerol drip.Results: Ears with significant EH showed significantly higher hearing levels and air-bone gaps (ABG), and higher absorbance values on WAI at low frequencies (560-600 Hz) than ears with mild or no EH. Changes in absorbance values were observed in some ears without threshold change on PTA.Conclusions and Significance: This study showed significantly higher absorbance values of acoustic energy with significant vestibular EH at low frequencies. Considering ABGs observed in ears with significant EH, the presence of EH in the vestibule might cause an obstacle to the transmission of acoustic energy to the inner ear.

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  220. A phase I/II trial of intraoperative breast radiotherapy in an Asian population: 10-year results with critical evaluation. Reviewed International journal

    Mariko Kawamura, Yoshiyuki Itoh, Takeshi Kamomae, Masataka Sawaki, Toyone Kikumori, Nobuyuki Tsunoda, Junji Ito, Yoshie Shimoyama, Hiroko Satake, Shinji Naganawa

    Journal of radiation research   Vol. 61 ( 4 ) page: 602 - 607   2020.7

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    Although phase III trials have been published comparing whole breast irradiation (WBI) with accelerated partial breast irradiation (APBI) using intraoperative radiotherapy (IORT), long-term follow-up results are lacking. We report the 10-year follow-up results of a prospective phase I/II clinical trial of IORT. The inclusion criteria were as follows: (i) tumor size <2.5 cm, (ii) desire for breast-conserving surgery, (iii) age >50 years, (iv) negative margins after resection and (v) sentinel lymph node-negative disease. A single dose of IORT (19-21 Gy) was delivered to the tumor bed in the operation room just after wide local excision of the primary breast cancer using a 6-12 MeV electron beam. Local recurrence was defined as recurrence or new disease within the treated breast and was evaluated annually using mammography and ultrasonography. A total of 32 patients were eligible for evaluation. The median patient age was 65 years and the median follow-up time was 10 years. Two patients experienced local recurrence just under the nipple, out of the irradiated field, after 8 years of follow-up. Three patients had contralateral breast cancer and one patient experienced bone metastasis after 10 years of follow-up. No patient experienced in-field recurrence nor breast cancer death. Eight patients had hypertrophic scarring at the last follow-up. There were no lung or heart adverse effects. This is the first report of 10-year follow-up results of IORT as APBI. The findings suggest that breast cancer with extended intraductal components should be treated with great caution.

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  221. Evaluation of segment 4 portal vein embolization added to right portal vein for right hepatic trisectionectomy: a retrospective propensity score-matched study. Reviewed

    Jun Ito, Tomohiro Komada, Kojiro Suzuki, Masaya Matsushima, Masahiro Nakatochi, Yumiko Kobayashi, Tomoki Ebata, Shinji Naganawa, Masato Nagino

    Journal of hepato-biliary-pancreatic sciences   Vol. 27 ( 6 ) page: 299 - 306   2020.6

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    BACKGROUND: Adding segment 4 (S4) portal vein embolization (PVE) to right PVE before right hepatic trisectionectomy is controversial. We retrospectively examined the effect of S4 PVE on segments 2 and 3 (S2+3) hypertrophy. METHODS: We reviewed patients with biliary carcinoma who underwent right PVE with (R3PVE) or without (R2PVE) S4 PVE using gelatin sponge particles and coils (2010-2019). Propensity score matching balanced the cohort for baseline characteristics, including total liver volume and S2+3 volume before PVE. We compared the groups regarding the S2+3 volume changes after PVE. RESULTS: Of 178 enrolled patients, 38 underwent R3PVE for right hepatic trisectionectomy and 140 underwent R2PVE for right hepatectomy. Twenty-eight patients from each group were respectively matched. The median absolute volume increase in (146 cm3 vs 70 cm3 ), hypertrophy rate of (52.4% vs 32.3%), and kinetic growth rate of (3.1 %/week vs 2.0 %/week) S2+3 were significantly higher in the R3PVE group than in the R2PVE group. In the pre-matched cohort, the rate of posthepatectomy liver failure and postoperative hospital stay did not significantly differ between the patients who underwent right hepatic trisectionectomy and right hepatectomy. CONCLUSION: R3PVE increased the S2+3 volume more effectively than R2PVE in patients with biliary carcinoma.

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  222. Unexpected radioactive iodine accumulation on whole-body scan after I-131 ablation therapy for differentiated thyroid cancer. Reviewed

    Shingo Iwano, Shinji Ito, Shinichiro Kamiya, Rintaro Ito, Katsuhiko Kato, Shinji Naganawa

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 205 - 215   2020.5

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    We retrospectively evaluated the frequency of unexpected accumulation of radioactive iodine on the post-therapy whole-body scan (Rx-WBS) after radioactive iodine (RAI) ablation therapy in patients with differentiated thyroid cancer (DTC). We searched our institutional database for Rx-WBSs of DTC patients who underwent RAI ablation or adjuvant therapy between 2012 and 2019. Patients with distant metastasis diagnosed by CT or PET/CT before therapy, and those had previously received RAI therapy were excluded. In total, 293 patients (201 female and 92 male, median age 54 years) were selected. Two nuclear medicine physicians interpreted the Rx-WBS images by determining the visual intensity of radioiodine uptake by the thyroid bed, cervical and mediastinal lymph nodes, lungs, and bone. Clinical features of the patients with and without the metastatic accumulation were compared by chi-square test and median test. Logistic regression analyses were performed to compare the association between the presence of metastatic accumulation and these clinical factors. Eighty-four of 293 patients (28.7%) showed metastatic accumulation. Patients with metastatic RAI accumulation showed a significantly higher frequency of pathological N1 (pN1) and serum thyroglobulin (Tg) > 1.5 ng/ml under TSH stimulation (p = 0.035 and p = 0.031, respectively). Logistic regression analysis indicated that a serum Tg > 1.5 ng/ml was significantly correlated with the presence of metastatic accumulation (odds ratio = 1.985; p = 0.033). In conclusion, Patients with Tg > 1.5 ng/ml were more likely to show metastatic accumulation. In addition, the presence of lymph node metastasis at the initial thyroid surgery was also associated with this unexpected metastatic accumulation.

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  223. 特集 基礎から学ぶ肺癌診断  肺癌の3次元CT・PET/CT診断―原発巣の診断と悪性度― Reviewed

    岩野信吾、伊藤信嗣、伊藤倫太郎、神谷晋一朗、加藤克彦、長縄慎二

    画像診断   Vol. 40 ( 5 ) page: 439 - 446   2020.5

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  224. 150周年記念記事 高次医用科学 創基150周年に寄せて Reviewed

    長縄慎二

    名大医学部学友時報   Vol. 843 ( - ) page: 10 - 10   2020.4

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  225. Evaluation of newly implemented dose calculation algorithms for multileaf collimator-based CyberKnife tumor-tracking radiotherapy. Reviewed International journal

    Kohei Kawata, Takeshi Kamomae, Hiroshi Oguchi, Fumitaka Kawabata, Kuniyasu Okudaira, Mariko Kawamura, Kazuhiro Ohtakara, Yoshiyuki Itoh, Shinji Naganawa

    Medical physics   Vol. 47 ( 3 ) page: 1391 - 1403   2020.3

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    PURPOSE: In the previous treatment planning system (TPS) for CyberKnife (CK), multileaf collimator (MLC)-based treatment plans could be created only by using the finite-size pencil beam (FSPB) algorithm. Recently, a new TPS, including the FSPB with lateral scaling option (FSPB+) and Monte Carlo (MC) algorithms, was developed. In this study, we performed basic and clinical end-to-end evaluations for MLC-based CK tumor-tracking radiotherapy using the MC, FSPB+, and FSPB. METHODS: Water- and lung-equivalent slab phantoms were combined to obtain the percentage depth dose (PDD) and off-center ratio (OCR). The CK M6 system and Precision TPS were employed, and PDDs and OCRs calculated by the MC, FSPB+, and FSPB were compared with the measured doses obtained for 30.8 × 30.8 mm2 and 60.0 × 61.6 mm2 fields. A lung motion phantom was used for clinical evaluation and MLC-based treatment plans were created using the MC. The doses were subsequently recalculated using the FSPB+ and FSPB, while maintaining the irradiation parameters. The calculated doses were compared with the doses measured using a microchamber (for target doses) or a radiochromic film (for dose profiles). The dose volume histogram (DVH) indices were compared for all plans. RESULTS: In homogeneous and inhomogeneous phantom geometries, the PDDs calculated by the MC and FSPB+ agreed with the measurements within ±2.0% for the region between the surface and a depth of 250 mm, whereas the doses calculated by the FSPB in the lung-equivalent phantom region were noticeably higher than the measurements, and the maximum dose differences were 6.1% and 4.4% for the 30.8 × 30.8 mm2 and 60.0 × 61.6 mm2 fields, respectively. The maximum distance to agreement values of the MC, FSPB+, and FSPB at the penumbra regions of OCRs were 1.0, 0.6, and 1.1 mm, respectively, but the best agreement was obtained between the MC-calculated curve and measurements at the boundary of the water- and lung-equivalent slabs, compared with those of the FSPB+ and FSPB. For clinical evaluations using the lung motion phantom, under the static motion condition, the dose errors measured by the microchamber were -1.0%, -1.9%, and 8.8% for MC, FSPB+, and FSPB, respectively; their gamma pass rates for the 3%/2 mm criterion comparing to film measurement were 98.4%, 87.6%, and 31.4% respectively. Under respiratory motion conditions, there was no noticeable decline in the gamma pass rates. In the DVH indices, for most of the gross tumor volume and planning target volume, significant differences were observed between the MC and FSPB, and between the FSPB+ and FSPB. Furthermore, significant differences were observed for lung Dmean , V15 Gy , and V20 Gy between the MC, FSPB+, and FSPB. CONCLUSIONS: The results indicate that the doses calculated using the MC and FSPB+ differed remarkably in inhomogeneous regions, compared with the FSPB. Because the MC was the most consistent with the measurements, it is recommended for final dose calculations in inhomogeneous regions such as the lung. Furthermore, the sufficient accuracy of dose delivery using MLC-based tumor-tracking radiotherapy by CK was demonstrated for clinical implementation.

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  226. Pharmacologic and non-pharmacologic interventions to prevent hypersensitivity reactions of non-ionic iodinated contrast media: a systematic review protocol Reviewed

    Hiroyasu Umakoshi, Takashi Nihashi, Hironori Shimamoto, Takehiro Yamada, Hiroaki Ishiguchi, Akira Takada, Naoki Hirasawa, Shunichi Ishihara, Yasuo Takehara, Shinji Naganawa, Matthew Davenport, Teruhiko Terasawa

    BMJ OPEN   Vol. 10 ( 3 ) page: e033023   2020.3

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    Introduction Iodinated contrast media are commonly used in medical imaging and can cause hypersensitivity reactions, including rare but severe life-threatening reactions. Although several prophylactic approaches have been proposed for severe reactions, their effects remain unclear. Therefore, we aim to review systematically the preventive effects of pharmacologic and non-pharmacologic interventions and predictors of acute, hypersensitivity reactions.Methods and analysis We will search the PubMed, EMBASE and Cochrane Central Register of Controlled Trials databases from 1 January 1990 through 31 December 2019 and will examine the bibliographies of eligible studies, pertinent review articles and clinical practice guidelines. We will include prospective and retrospective studies of any design that evaluated the effects of pharmacological and non-pharmacological preventive interventions for adverse reactions of non-ionic iodinated contrast media. Two assessors will independently extract the characteristics of the study and intervention and the quantitative results. Two independent reviewers will assess the risk of bias using standard design-specific validity assessment tools. The primary outcome will be reduction in acute contrast media-induced hypersensitivity reactions. The secondary outcomes will include characteristics associated with the development of contrast media-induced acute hypersensitivity reactions, and adverse events associated with specific preventive interventions. Unique premedication regimens (eg, dose, drug and duration) and non-pharmacological strategies will be analysed separately. Average-risk and high-risk patients will be considered separately. A meta-analysis will be performed if appropriate.Ethics and dissemination Ethics approval is not applicable, as this will be a secondary analysis of publicly available data. The results of the analysis will be submitted for publication in a peer reviewed journal.

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  227. 脳動脈瘤破裂リスク評価のための磁気共鳴流体解析と計算流体解析による形態ならびに血流動態バイオマーカーの検討 Reviewed

    MAJUWANA GAMAGE, 礒田治夫、泉 孝嗣、若林俊彦、長縄慎二

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 令和元年度活動報告書   Vol. - ( - ) page: 27 - 27   2020.3

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  228. 磁気共鳴画像によるNeurofluids動態の解明 Reviewed

    長縄慎二、田岡俊昭、川井 恒

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 令和元年度活動報告書   Vol. - ( - ) page: 30 - 30   2020.3

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  229. 【基礎から学ぶ肺癌診断】肺癌の3次元CT・PET/CT診断 原発巣の診断と悪性度 Reviewed

    岩野 信吾, 伊藤 信嗣, 伊藤 倫太郎, 神谷 晋一朗, 加藤 克彦, 長縄 慎二

    画像診断   Vol. 40 ( 5 ) page: 439 - 446   2020.3

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    <文献概要>肺癌の臨床病期分類(TNM分類)は主に画像診断に基づいて行われる.2017年に改訂されたTNM分類では,T因子(サイズ)の診断が複雑になった.病理学的浸潤径に相当する充実成分径の計測はthinsection CTで行うのが基本であるが,3次元CTやPET/CTを利用することで精度の向上が期待できる.

    Other Link: https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00235&link_issn=&doc_id=20200408090014&doc_link_id=10.15105%2FGZ.0000001656&url=https%3A%2F%2Fdoi.org%2F10.15105%2FGZ.0000001656&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  230. White matter microstructural changes in tuberous sclerosis: Evaluation by neurite orientation dispersion and density imaging (NODDI) and diffusion tensor images. Reviewed International journal

    Toshiaki Taoka, Noriko Aida, Yuta Fujii, Kazushi Ichikawa, Hisashi Kawai, Toshiki Nakane, Rintaro Ito, Shinji Naganawa

    Scientific reports   Vol. 10 ( 1 ) page: 436 - 436   2020.1

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    Neurite orientation dispersion and density imaging (NODDI) is a novel diffusion method for evaluating tissue microstructure, and may provide additional information over conventional diffusion tensor imaging (DTI). We evaluated NODDI and DTI parameters in cases of tuberous sclerosis (TS) to assess microstructural changes in the white matter. Eleven cases of tuberous sclerosis and eight age-matched controls underwent NODDI and DTI. We performed qualitative analysis and tract-based spatial statistics (TBSS) analysis of the NODDI parameters (Ficv: intracellular volume fraction, Fiso: isotropic fraction, ODI: orientation dispersion index) as well as DTI parameters (MD: mean diffusivity, FA: fractional anisotropy). We also performed a correlation analysis between clinical symptoms and parameters. The qualitative analysis indicated that the Ficv had a lower value in TS cases particularly in the tubers adjacent to the white matter. The TBSS analysis showed that the TS cases had decreased Ficv in a greater area compared to the other parameters including MD. In particular, the Ficv was decreased in deep white matter, such as the superior longitudinal fascicles (SLF). The application of NODDI to TS cases revealed tissue microstructural changes, and particularly the Ficv could detect more widespread abnormalities in white matter structure compared to DTI parameters.

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  231. Glymphatic imaging using MRI. Reviewed International journal

    Toshiaki Taoka, Shinji Naganawa

    Journal of magnetic resonance imaging : JMRI   Vol. 51 ( 1 ) page: 11 - 24   2020.1

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    In recent years, the existence of a mass transport system in the brain via cerebrospinal fluid (CSF) or interstitial fluid (ISF) has been suggested by many studies. The glymphatic system is hypothesized to be a waste clearance system of the CSF through the perivascular and interstitial spaces in the brain. Tracer studies have primarily been used to visualize or evaluate the waste clearance system in the brain, and evidence for this system has accumulated. The initial study that identified the glymphatic system was an in vivo tracer study in mice. In that study, fluorescent tracers were injected into the cisterna magna and visualized by two-photon microscopy. MRI has also been used to evaluate glymphatic function primarily with gadolinium-based contrast agents (GBCAs) as tracers. A number of GBCA studies evaluating glymphatic function have been conducted using either intrathecal or intravenous injections. Stable isotopes, such as 17 O-labeled water, may also be used as tracers since they can be detected by MRI. In addition to tracer studies, several other approaches have been used to evaluate ISF dynamics within the brain, including diffusion imaging. Phase contrast evaluation is a powerful method for visualizing flow within the CSF space. In order to evaluate the movement of water within tissue, diffusion-weighted MRI represents another promising technique, and several studies have utilized diffusion techniques for the evaluation of the glymphatic system. This review will discuss the findings of these diffusion studies. Level of Evidence: 5 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2020;51:11-24.

    DOI: 10.1002/jmri.26892

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  232. Celebrating the beginning of international journal collaboration. Reviewed

    Shinji Naganawa, Yukunori Korogi

    Japanese journal of radiology   Vol. 38 ( 1 ) page: 1 - 2   2020.1

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    DOI: 10.1007/s11604-019-00904-5

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  233. 中枢神経系原発anaplastic lymphoma kinase陽性未分化大細胞リンパ腫の1例 Reviewed

    佐々木 裕太郎, 中道 玲瑛, 伊藤 信嗣, 川井 恒, 岩野 信吾, 田岡 俊昭, 加藤 克彦, 川島 直美, 下山 芳江, 長縄 慎二

    映像情報Medical   Vol. 52 ( 1 ) page: 82 - 83   2020.1

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  234. Quantification of Endolymphatic Space Volume after Intravenous Administration of a Single Dose of Gadolinium-based Contrast Agent: 3D-real Inversion Recovery versus HYDROPS-Mi2. Reviewed

    Toshio Ohashi, Shinji Naganawa, Ai Takeuchi, Toshio Katagiri, Kayao Kuno

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 2 ) page: 119 - 124   2020

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    PURPOSE: Recently, the use of 3D real inversion recovery (3D-real IR) imaging has been proposed for the evaluation of endolymphatic hydrops (EH). This method shows similar contrast between the endolymphatic and perilymphatic spaces and surrounding bone compared with the hybrid of reversed image of positive endolymph signal and native image of perilymph signal multiplied with heavily T2-weighted MR cisternography (HYDROPS-Mi2) image. We measured the volume of the endolymphatic space using 3D-real IR and HYDROPS-Mi2 images, and compared the measurements obtained with both techniques. METHODS: HYDROPS-Mi2 and 3D-real IR images were obtained for 30 ears from 15 patients with clinical suspicion of EH; imaging was performed 4 h after intravenous administration of a single dose of gadolinium-based contrast agent. We measured the volume of the endolymphatic space in the cochlea and vestibule by manually drawing the regions of interest. The correlation between endolymphatic volume determined from HYDROPS-Mi2 images and 3D-real IR images was calculated. RESULTS: There was a strong positive linear correlation between the cochlear and vestibular endolymphatic volume determined from HYDROPS-Mi2 and 3D-real IR images. The Spearman's rank correlation coefficient (ρ) between the measurements obtained with both images was 0.805 (P < 0.001) for the cochlea and 0.826 (P < 0.001) for the vestibule. CONCLUSION: The endolymphatic volume measured using 3D-real IR images strongly correlated with that measured using HYDROPS-Mi2 images. Thus, 3D-real IR imaging might be a suitable method for the measurement of endolymphatic volume.

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  235. The Space between the Pial Sheath and the Cortical Venous Wall May Connect to the Meningeal Lymphatics. Reviewed

    Shinji Naganawa, Rintaro Ito, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 1 ) page: 1 - 4   2020

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    We currently obtain pre- and post-contrast enhanced whole brain 3D-real inversion recovery images for the evaluation of endolymphatic hydrops. We noticed that the space between the pial sheath surrounding the cortical veins and the cortical venous wall is enhanced and this enhancement seems to connect to the meningeal lymphatics along superior sagittal sinus. This new anatomical concept regarding the outflow from the glymphatic system might be important for the future research in neuroscience.

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  236. Detection of IV-gadolinium Leakage from the Cortical Veins into the CSF Using MR Fingerprinting. Reviewed

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Hirokazu Kawaguchi, Katsuya Maruyama, Katsutoshi Murata, Gregor Körzdörfer, Josef Pfeuffer, Mathias Nittka, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 2 ) page: 141 - 146   2020

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    PURPOSE: It has been reported that leakage of intravenously administered gadolinium-based contrast agents (IV-GBCAs) into the cerebrospinal fluid (CSF) from the cortical veins even in healthy subjects can be detected using a highly sensitive pulse sequence such as heavily T2-weighted 3D fluid-attenuated inversion recovery and 3D-real inversion recovery (IR). The purpose of this study was to evaluate the feasibility of MR fingerprinting to detect GBCA leakage from the cortical veins after IV-GBCA. MATERIALS: Fourteen patients with suspected endolymphatic hydrops (EH) who received a single dose of IV-GBCA (39-79 years old) were included. The real IR images as well as MR fingerprinting images were obtained at 4 h after IV-GBCA. T1 and T2 values were obtained using MR fingerprinting and analyzed in ROIs covering intense GBCA leakage, and non-leakage areas of the CSF as determined on real IR images. The scan time for real IR imaging was 10 min and that for MR fingerprinting was 41 s. RESULTS: The mean T1 value of the ROI in the area of GBCA leakage was 2422 ± 261 ms and that in the non-leakage area was 3851 ± 235 ms (P < 0.01). There was no overlap between the T1 values in the area of GBCA leakage and those in the non-leakage area.The mean T2 value in the area of GBCA leakage was 319 ± 90 ms and that in the non-leakage area was 670 ± 166 ms (P < 0.01). There was some overlap between the T2 values in the area of GBCA leakage and those in the non-leakage area. CONCLUSION: Leaked GBCA from the cortical veins into the surrounding CSF can be detected using MR fingerprinting obtained in <1 min.

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  237. Confirmation of Age-dependence in the Leakage of Contrast Medium around the Cortical Veins into Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agent. Reviewed

    Shinji Naganawa, Rintaro Ito, Hisashi Kawai, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 4 ) page: 375 - 381   2020

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    PURPOSE: It has been reported previously that intravenously administered gadolinium-based contrast agent (GBCA) leaks into the subarachnoid space around the cortical veins at 4 h after injection in all old people over 37 years, but not in younger people up to 37 years of age in 3D-real IR images. The purpose of this study was to investigate whether there was a strict threshold of 37 years of age for the leakage of the GBCA into the subarachnoid space. METHODS: The subjects included 190 patients, that were scanned for 3D-real IR images at 4 hours after intravenous injection of GBCA as a diagnostic test for endolymphatic hydrops. The patient's age ranged from 14 to 81 years. Two experienced neuroradiologists evaluated the images to determine whether the GBCA leakage around the cortical veins was positive or negative. Any discrepancies between the two observers were discussed and a consensus was obtained.A Mann-Whitney U test and receiver operating characteristic (ROC) curve analysis were used to compare the positive and the negative group and to set the age cut-off value for the prediction of GBCA leakage. RESULTS: The GBCA leakage around the cortical veins was negative in 35 patients and positive in 155 patients. The average age was 33 ± 11 years in the negative group, and 55 ± 12 years in the positive group (P < 0.01). In the ROC analysis for the age and leakage of the GBCA, an area under the curve was 0.905 and the cut-off age was 37.317 years (sensitivity of 0.942 and specificity of 0.771). CONCLUSION: Intravenously administered GBCA leaks into the subarachnoid space around the cortical veins in most patients over 37 years of age. However, it should be noted that it can be found occasionally in patients under 37 years of age.

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  238. Comprehensive Evaluation of B1+-corrected FISP-based Magnetic Resonance Fingerprinting: Accuracy, Repeatability and Reproducibility of T1 and T2 Relaxation Times for ISMRM/NIST System Phantom and Volunteers. Reviewed

    Yutaka Kato, Kazushige Ichikawa, Kuniyasu Okudaira, Toshiaki Taoka, Hirokazu Kawaguchi, Katsutoshi Murata, Katsuya Maruyama, Gregor Koerzdoerfer, Josef Pfeuffer, Mathias Nittka, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 3 ) page: 168 - 175   2020

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    PURPOSE: This study aimed to evaluate comprehensively; accuracy, repeatability and reproducibility of T1 and T2 relaxation times measured by magnetic resonance fingerprinting using B1+-corrected fast imaging with steady-state precession (FISP-MRF). METHODS: The International Society of Magnetic Resonance in Medicine/National Institute of Standards and Technology (ISMRM/NIST) phantom was scanned for 100 days, and six healthy volunteers for 5 days using a FISP-MRF prototype sequence. Accuracy was evaluated on the phantom by comparing relaxation times measured by FISP-MRF with the reference values provided by the phantom manufacturer. Daily repeatability was characterized as the coefficient of variation (CV) of the measurements over 100 days for the phantom and over 5 days for volunteers. In addition, the cross-scanner reproducibility was evaluated in volunteers. RESULTS: In the phantom study, T1 and T2 values from FISP-MRF showed a strong linear correlation with the reference values of the phantom (R2 = 0.9963 for T1; R2 = 0.9966 for T2). CVs were <1.0% for T1 values larger than 300 ms, and <3.0% for T2 values across a wide range. In the volunteer study, CVs for both T1 and T2 values were <5.0%, except for one subject. In addition, all T2 values estimated by FISP-MRF in vivo were lower than those measured with conventional mapping sequences reported in previous studies. The cross-scanner variation of T1 and T2 showed good agreement between two different scanners in the volunteers. CONCLUSION: B1+-corrected FISP-MRF showed an acceptable accuracy, repeatability and reproducibility in the phantom and volunteer studies.

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  239. Assessing the Risk of Intracranial Aneurysm Rupture Using Morphological and Hemodynamic Biomarkers Evaluated from Magnetic Resonance Fluid Dynamics and Computational Fluid Dynamics. Reviewed

    Roshani Perera, Haruo Isoda, Kenta Ishiguro, Takashi Mizuno, Yasuo Takehara, Masaki Terada, Chiharu Tanoi, Takehiro Naito, Harumi Sakahara, Hisaya Hiramatsu, Hiroki Namba, Takashi Izumi, Toshihiko Wakabayashi, Takafumi Kosugi, Yuki Onishi, Marcus Alley, Yoshiaki Komori, Mitsuru Ikeda, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 4 ) page: 333 - 344   2020

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    PURPOSE: Evaluate in vivo hemodynamic and morphological biomarkers of intracranial aneurysms, using magnetic resonance fluid dynamics (MRFD) and MR-based patient specific computational fluid dynamics (CFD) in order to assess the risk of rupture. METHODS: Forty-eight intracranial aneurysms (10 ruptured, 38 unruptured) were scrutinized for six morphological and 10 hemodynamic biomarkers. Morphological biomarkers were calculated based on 3D time-of-flight magnetic resonance angiography (3D TOF MRA) in MRFD analysis. Hemodynamic biomarkers were assessed using both MRFD and CFD analyses. MRFD was performed using 3D TOF MRA and 3D cine phase-contrast magnetic resonance imaging (3D cine PC MRI). CFD was performed utilizing patient specific inflow-outflow boundary conditions derived from 3D cine PC MRI. Univariate analysis was carried out to identify statistically significant biomarkers for aneurysm rupture and receiver operating characteristic (ROC) analysis was performed for the significant biomarkers. Binary logistic regression was performed to identify independent predictive biomarkers. RESULTS: Morphological biomarker analysis revealed that aneurysm size [P = 0.021], volume [P = 0.035] and size ratio [P = 0.039] were statistically significantly different between the two groups. In hemodynamic biomarker analysis, MRFD results indicated that ruptured aneurysms had higher oscillatory shear index (OSI) [OSI.max, P = 0.037] and higher relative residence time (RRT) [RRT.ave, P = 0.035] compared with unruptured aneurysms. Correspondingly CFD analysis demonstrated significant differences for both average and maximum OSI [OSI.ave, P = 0.008; OSI.max, P = 0.01] and maximum RRT [RRT.max, P = 0.045]. ROC analysis revealed AUC values greater than 0.7 for all significant biomarkers. Aneurysm volume [AUC, 0.718; 95% CI, 0.491-0.946] and average OSI obtained from CFD [AUC, 0.774; 95% CI, 0.586-0.961] were retained in the respective logistic regression models. CONCLUSION: Both morphological and hemodynamic biomarkers have significant influence on intracranial aneurysm rupture. Aneurysm size, volume, size ratio, OSI and RRT could be potential biomarkers to assess aneurysm rupture risk.

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  240. Kinetic volume analysis on dynamic contrast-enhanced MRI of triple-negative breast cancer: associations with survival outcomes. Reviewed International journal

    Yoko Hayashi, Hiroko Satake, Satoko Ishigaki, Rintaro Ito, Mariko Kawamura, Hisashi Kawai, Shingo Iwano, Shinji Naganawa

    The British journal of radiology   Vol. 93 ( 1106 ) page: 20190712 - 20190712   2020

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    OBJECTIVE: To evaluate the associations between computer-aided diagnosis (CAD)-generated kinetic volume parameters and survival in triple-negative breast cancer (TNBC) patients. METHODS: 40 patients with TNBC who underwent pre-operative MRI between March 2008 and March 2014 were included. We analyzed CAD-generated parameters on dynamic contrast-enhanced MRI, visual MRI assessment, and histopathological data. Cox proportional hazards models were used to determine associations with survival outcomes. RESULTS: 12 of the 40 (30.0%) patients experienced recurrence and 7 died of breast cancer after a median follow-up of 73.6 months. In multivariate analysis, higher percentage volume (%V) with more than 200% initial enhancement rate correlated with worse disease-specific survival (hazard ratio, 1.12; 95% confidence interval, 1.02-1.22; p-value, 0.014) and higher %V with more than 100% initial enhancement rate followed by persistent curve type at 30% threshold correlated with worse disease-specific survival (hazard ratio, 1.33; 95% confidence interval, 1.10-1.61; p-value, 0.004) and disease-free survival (hazard ratio, 1.27; 95% confidence interval, 1.12-1.43; p-value, 0.000). CONCLUSION: CAD-generated kinetic volume parameters may correlate with survival in TNBC patients. Further study would be necessary to validate our results on larger cohorts. ADVANCES IN KNOWLEDGE: CAD generated kinetic volume parameters on breast MRI can predict recurrence and survival outcome of patients in TNBC. Varying the enhancement threshold improved the predictive performance of CAD generated kinetic volume parameter.

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  241. Optimal Plane Selection for Measuring Post-prandial Blood Flow Increase within the Superior Mesenteric Artery: Analysis Using 4D Flow and Computational Fluid Dynamics. Reviewed

    Masataka Sugiyama, Yasuo Takehara, Masanori Kawate, Naoki Ooishi, Masaki Terada, Haruo Isoda, Harumi Sakahara, Shinji Naganawa, Kevin M Johnson, Oliver Wieben, Tetsuya Wakayama, Atsushi Nozaki, Hiroyuki Kabasawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 4 ) page: 366 - 374   2020

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    PURPOSE: 2D cine phase contrast (PC)-MRI is a standard velocimetry for the superior mesenteric artery (SMA); however, the optimal localization of the measurement plane has never been fully discussed previously. The purpose of this Institutional Review Board approved prospective and single arm study is to test whether flow velocimetry of the SMA with combined use of 2D cine PC-MRI and meal challenge is dependent on the localizations of the measurement planes and to seek optimal section for velocimetry. METHODS: Seven healthy volunteers underwent cardiac phase resolved ECG gated 2D cine PC-MRI pre- and 30 min post-meal challenge at three measurement planes: proximal, curved mid section and distal straight section of the SMA at 3T. 4D Flow using 3D cine PC-MRI with vastly undersampled isotropic projection imaging (PC VIPR) was also performed right after 2D cine PC-MRI to delineate the flow dynamics within the SMA using streamline analysis. Two radiologists measured flow velocities, and rated the appearances of the abnormal flow in the SMA on streamlines derived from the 4D Flow and the computational fluid dynamics (CFD). RESULTS: 2D cine PC-MRI measured increased temporally averaged flow velocity (mm/s) after the meal challenge only in the proximal (129.3 vs. 97.8, P = 0.0313) and distal section (166.9 vs. 96.2, P = 0.0313), not in the curved mid section (113.1 vs. 85.5, P = 0.0625). The average velocities were highest and their standard errors (8.5-26.5) were smallest at the distal straight section both before and after the meal challenge as compared with other sections. The streamline analysis depicted more frequent appearances of vertical or helical flow in the curved mid section both on 4D Flow and CFD (κ: 0.27-0.68). CONCLUSION: SMA velocimetry with 2D cine PC-MRI was dependent on the localization of the measurement planes. Distal straight section, not in the curved mid section is recommended for MR velocimetry.

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  242. Assessment of Severity in Chronic Thromboembolic Pulmonary Hypertension by Quantitative Parameters of Dual-Energy Computed Tomography Reviewed

    Tsutsumi Yoshinori, Iwano Shingo, Okumura Naoki, Adachi Shiro, Abe Shinji, Kondo Takahisa, Kato Katsuhiko, Naganawa Shinji

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY   Vol. 44 ( 4 ) page: 578 - 585   2020

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  243. Abnormal Flow Dynamics Result in Low Wall Shear Stress and High Oscillatory Shear Index in Abdominal Aortic Dilatation: Initial in vivo Assessment with 4D-flow MRI. Reviewed

    Yasuo Takehara, Haruo Isoda, Mamoru Takahashi, Naoki Unno, Norihiko Shiiya, Takasuke Ushio, Satoshi Goshima, Shinji Naganawa, Marcus Alley, Tetsuya Wakayama, Atsushi Nozaki

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 3 ) page: 235 - 246   2020

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    PURPOSE: To characterize the non-laminar flow dynamics and resultant decreased wall shear stress (WSS) and high oscillatory shear index (OSI) of the infrarenal abdominal aortic dilatation, cardiac phase-resolved 3D phase-contrast MRI (4D-flow MRI) was performed. METHODS: The prospective single-arm study was approved by the Institutional Review Board and included 18 subjects (median 67.5 years) with the dilated infrarenal aorta (median diameter 35 mm). 4D-flow MRI was conducted on a 1.5T MRI system. On 3D streamline images, laminar and non-laminar (i.e., vortex or helical) flow patterns were visually assessed both for the dilated aorta and for the undilated upstream aorta. Cardiac phase-resolved flow velocities, WSS and OSI, were also measured for the dilated aorta and the upstream undilated aorta. RESULTS: Non-laminar flow represented by vortex or helical flow was more frequent and overt in the dilated aorta than in the undilated upstream aorta (P < 0.0156) with a very good interobserver agreement (weighted kappa: 0.82-1.0). The WSS was lower, and the OSI was higher on the dilated aortic wall compared with the proximal undilated segments. In mid-systole, mean spatially-averaged WSS was 0.20 ± 0.016 Pa for the dilated aorta vs. 0.68 ± 0.071 Pa for undilated upstream aorta (P < 0.0001), and OSI on the dilated aortic wall was 0.093 ± 0.010 vs. 0.041 ± 0.0089 (P = 0.013). The maximum values and the amplitudes of the WSS at the dilated aorta were inversely proportional to the ratio of dilated/undilated aortic diameter (r = -0.694, P = 0.0014). CONCLUSION: 4D-flow can characterize abnormal non-laminar flow dynamics within the dilated aorta in vivo. The wall of the infrarenal aortic dilatation is continuously and increasingly affected by atherogenic stimuli due to the flow disturbances represented by vortex or helical flow, which is reflected by lower WSS and higher OSI.

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  244. 2020年 最新医療機器の現状と展望 CTおよびMRIなどの画像診断装置の今後の在り方と展望 Reviewed

    長縄慎二

    月刊新医療データブック・シリーズ 医療機器システム白書   Vol. - ( - ) page: 12 - 15   2019.12

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  245. 私と医療 New Med Essay ―第176回 動機はいい加減だったものの、真面目に取り組めばこそ― Reviewed

    長縄慎二

    月刊新医療   Vol. 540 ( - ) page: 77 - 77   2019.11

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  246. 正常老化におけるTHK5351分布様式と安静時機能的ネットワークの関係性

    吉田 有佑, 横井 孝政, 渡辺 宏久, 山口 博司, Bagarinao Epifanio, 桝田 道人, 加藤 隼康, 小倉 礼, 大嶽 れい子, 川畑 和也, 原 一洋, 勝野 雅央, 加藤 克彦, 長縄 慎二, 岡村 信行, 矢内 一彦, 祖父江 元

    臨床神経学   Vol. 59 ( Suppl. ) page: S297 - S297   2019.11

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  247. Balloon-Occluded Retrograde Transvenous Obliteration for Fundal Gastric Variceal Bleeding in a Small Child. Reviewed International journal

    Tomohiro Komada, Kojiro Suzuki, Kazuo Oshima, Masaya Matsushima, Ken Nagasaka, Shinji Naganawa

    Journal of vascular and interventional radiology : JVIR   Vol. 30 ( 10 ) page: 1624 - 1625   2019.10

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    DOI: 10.1016/j.jvir.2019.06.022

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  248. ちょっと気になる胆・膵画像 ティーチングファイルから(第43回) 術前診断が困難であった膵lymphangiomaの1例

    小川 浩, 竹原 康雄, 長縄 慎二, 高見 秀樹, 中黒 匡人

    胆と膵   Vol. 40 ( 10 ) page: 841 - 844   2019.10

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  249. Glymphatic systemとMRI―ヒトでの可視化に向けた取り組み Reviewed

    長縄慎二

    医学のあゆみ   Vol. 270 ( 13 ) page: 1189 - 1192   2019.10

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  250. Multi-window levels and widths imaging 画像変換による新たな読影手法の検討

    伊藤 倫太郎, 岩野 信吾, 小田 紘久, 森 健策, 長縄 慎二

    日本医学放射線学会秋季臨床大会抄録集   Vol. 55回   page: S531 - S532   2019.9

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  251. Reorganization of brain networks and its association with general cognitive performance over the adult lifespan. Reviewed International journal

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshiaki Taoka, Shuji Koyama, Hiroki C Tanabe, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Norio Ozaki, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Gen Sobue

    Scientific reports   Vol. 9 ( 1 ) page: 11352 - 11352   2019.8

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    Healthy aging is associated with structural and functional changes in the brain even in individuals who are free of neurodegenerative diseases. Using resting state functional magnetic resonance imaging data from a carefully selected cohort of participants, we examined cross sectional changes in the functional organization of several large-scale brain networks over the adult lifespan and its potential association with general cognitive performance. Converging results from multiple analyses at the voxel, node, and network levels showed widespread reorganization of functional brain networks with increasing age. Specifically, the primary processing (visual and sensorimotor) and visuospatial (dorsal attention) networks showed diminished network integrity, while the so-called core neurocognitive (executive control, salience, and default mode) and basal ganglia networks exhibited relatively preserved between-network connections. The visuospatial and precuneus networks also showed significantly more widespread increased connectivity with other networks. Graph analysis suggested that this reorganization progressed towards a more integrated network topology. General cognitive performance, assessed by Addenbrooke's Cognitive Examination-Revised total score, was positively correlated with between-network connectivity among the core neurocognitive and basal ganglia networks and the integrity of the primary processing and visuospatial networks. Mediation analyses further indicated that the observed association between aging and relative decline in cognitive performance could be mediated by changes in relevant functional connectivity measures. Overall, these findings provided further evidence supporting widespread age-related brain network reorganization and its potential association with general cognitive performance during healthy aging.

    DOI: 10.1038/s41598-019-47922-x

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  252. High-dose-rate intracavitary brachytherapy for recurrent cervical cancer in the vaginal stump after hysterectomy Reviewed

    Kozai Yuka, Itoh Yoshiyuki, Kawamura Mariko, Nakahara Rie, Ito Junji, Okada Tohru, Kikkawa Fumitaka, Ikeda Mitsuru, Naganawa Shinji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 3 ) page: 351 - 358   2019.8

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    This study aimed to evaluate the treatment outcomes of patients who received high-dose-rate intracavitary brachytherapy (HDR-BT) using Iridium-192 with or without external beam radiotherapy as definitive treatment for recurrent cervical cancer after hysterectomy. Thirty-six patients with local recurrence after hysterectomy received radiotherapy including HDR-BT from 2005 to 2013. Overall survival, local control rate, and progression-free survival were estimated retrospectively via the Kaplan-Meier method. Late adverse events were also scored using the Common Terminology Criteria for Adverse Events (version 3.0). Median follow-up time was 38 (range, 7.4-101.3) months. The 3-year estimates of overall survival, local control rate, and progression-free survival were 100.0%, 82.8%, and 76.8%, respectively. Two patients (5.6%) had grade 2 lymphedema, but no other adverse events greater than grade 2 were reported. In conclusion, HDR-BT was an effective treatment modality for patients with cervical cancer recurrence in the vaginal stump.

    DOI: 10.18999/nagjms.81.3.351

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  253. Whole abdominopelvic intensity-modulated radiation therapy for peritoneal disseminated rhabdomyosarcoma with three-year follow-up: a case report. Reviewed International journal

    Mariko Kawamura, Kuniyasu Okudaira, Yoshiyuki Itoh, Takeshi Kamomae, Eri Nishikawa, Hideki Muramatsu, Yoshiyuki Takahashi, Kazuki Yokota, Shinji Naganawa

    Radiation oncology (London, England)   Vol. 14 ( 1 ) page: 127 - 127   2019.7

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    BACKGROUND: The role of local radiotherapy in the treatment of metastatic rhabdomyosarcoma is important. However, with peritoneal dissemination, the application of local therapy is challenging. Although there are few reports addressing the efficacy of the whole abdominopelvic irradiation to peritoneal disseminated rhabdomyosarcoma patients, no precise curse of treatment nor the follow up result is explained in paper nor in the text. CASE PRESENTATION: Six years old rhabdomyosarcoma boy with peritoneal dissemination was treated at our facility under COG D9803 protocol (vincristine, dactinomycin, and cyclophosphamide (VAC)). He underwent tumor resection on the 14th week according to the protocol. During surgery, the 2-cm residual tumor was completely resected, but in the pelvis, numerous nodules that were suspected as peritoneal disseminated tumors were observed. We administered 30 Gy/20fr whole abdominopelvic radiotherapy using volumetric modulated arc therapy (VMAT) technique and a 6 Gy sequential boost to pelvis after the surgery and completed the protocol treatment. During the course of treatment, the patient experienced G4 hematological toxicity and received multiple transfusions, particularly after whole abdominopelvic irradiation. He has achieved complete remission and is alive without evidence of recurrence and severe late adverse effect for 3 years. In terms of growth, his height and weight are within the average values for Japanese boys at the same age. CONCLUSION: By using the VMAT technique, a patient with peritoneal disseminated rhabdomyosarcoma can be treated, and a dose of 30 Gy to the whole abdominopelvis with concurrent chemotherapy may be tolerable.

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  254. 2.胸部領域 胸部画像診断におけるAIと臨床研究について Reviewed

    伊藤倫太郎、岩野信吾、長縄慎二

    INNERVISION   Vol. 34 ( 7 ) page: 25 - 28   2019.7

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  255. Postoperative recurrence of clinical early-stage non-small cell lung cancers: a comparison between solid and subsolid nodules. Reviewed International journal

    Shingo Iwano, Hiroyasu Umakoshi, Shinichiro Kamiya, Kohei Yokoi, Koji Kawaguchi, Takayuki Fukui, Shinji Naganawa

    Cancer imaging : the official publication of the International Cancer Imaging Society   Vol. 19 ( 1 ) page: 33 - 33   2019.6

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    BACKGROUND: For subsolid non-small cell lung cancers (NSCLCs), solid size (SS), which is the maximal diameter of the solid component, correlates more accurately with tumor prognosis than the total size, which is the maximal diameter of the entire tumor, including ground-glass opacity. We reviewed the propriety of the TNM staging based on the SS for early-stage NSCLCs. METHODS: We retrospectively reviewed the preoperative radiological reports, clinical records, and pathological reports of NSCLC cases in our hospital between 2010 and 2013, and clinical stage (c-Stage) 0 and I tumors were selected. Disease-free survival (DFS), based on survival analysis, was used to assess the tumor characteristics that predicted the prognosis. RESULTS: A total of 247 NSCLC diagnoses in 231 patients (88 women and 143 men; age, 67 ± 7 years) were included in our cohort. They were classified into solid (n = 131) and subsolid (n = 116) nodules. The DFS curves indicated that prognosis was significantly worse in the following order: c-Stage 0, c-Stage IA, and c-Stage IB tumors (p = 0.016). Patients with solid nodules showed a significantly worse prognosis than patients with subsolid nodules (p < 0.001). A multivariate Cox proportional hazards model showed that the significant predictive factors for DFS were c-Stage (hazard ratio, 1.600; p = 0.020) and solid nodules (hazard ratio, 3.077; p = 0.031). CONCLUSIONS: For early-stage NSCLCs, the c-Stage based on the SS in subsolid nodules was useful for predicting postoperative DFS. In addition, whether nodules were solid or subsolid was another independent prognostic factor.

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  256. Monitoring of fatigue in radiologists during prolonged image interpretation using fNIRS. Reviewed

    Takashi Nihashi, Takeo Ishigaki, Hiroko Satake, Shinji Ito, Osamu Kaii, Yoshine Mori, Kazuhiro Shimamoto, Hiromichi Fukushima, Kojiro Suzuki, Hiroyasu Umakoshi, Mitsuo Ohashi, Fumio Kawaguchi, Shinji Naganawa

    Japanese journal of radiology   Vol. 37 ( 6 ) page: 437 - 448   2019.6

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    PURPOSE: To determine whether functional near-infrared spectroscopy (fNIRS) allows monitoring fatigue in radiologists during prolonged image interpretation. MATERIALS AND METHODS: Nine radiologists participated as subjects in the present study and continuously interpreted medical images and generated reports for cases for more than 4 h under real clinical work conditions. We measured changes in oxygenated hemoglobin concentrations [oxy-Hb] in the prefrontal cortex using 16-channel fNIRS (OEG16ME, Spectratech) every hour during the Stroop task to evaluate fatigue of radiologists and recorded fatigue scale (FS) as a behavior data. RESULTS: Two subjects showed a subjective feeling of fatigue and an apparent decrease in brain activity after 4 h, so the experiment was completed in 4 h. The remaining seven subjects continued the experiment up to 5 h. FS decreased with time, and a significant reduction was observed between before and the end of image interpretation. Seven out of nine subjects showed a minimum [oxy-Hb] change at the end of prolonged image interpretation. The mean change of [oxy-Hb] at the end of all nine subjects was significantly less than the maximum during image interpretation. CONCLUSION: fNIRS using the change of [oxy-Hb] may be useful for monitoring fatigue in radiologists during image interpretation.

    DOI: 10.1007/s11604-019-00826-2

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  257. 食道平滑筋腫 Reviewed

    兵藤良太、岩野信吾、長縄慎二

    画像診断   Vol. 39 ( 7 ) page: 662 - 663   2019.6

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  258. 【人工知能が医療を変える!医療分野におけるAI研究開発最前線2019】領域別・画像診断におけるAI研究開発の最前線 胸部領域 胸部画像診断におけるAIと臨床研究について

    伊藤 倫太郎, 岩野 信吾, 長縄 慎二

    INNERVISION   Vol. 34 ( 7 ) page: 25 - 28   2019.6

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    2006年から始まった第三次AIブームによりAIの研究が加速度的に進み、現在ではスマートフォンのカメラや音声入力など身近なものに活用されている。放射線医学においては古くから人工知能(AI)を用いた研究が行われ、臨床にも応用されていた。最近では、さらに発展したAIを用いたCADの開発が盛んであり、世界中の研究者が開発を競っている。本稿では、加速度的に進歩するAIと放射線医学とのかかわりについて、主に胸部画像診断の観点から現在の状況と問題点についてまとめ、実際の研究例について提示する。(著者抄録)

  259. Increased signal intensity of low-concentration gadolinium contrast agent by longer repetition time in heavily T<sub>2</sub>-weighted-3D-FLAIR.

    Kato Y, Bokura K, Taoka T, Naganawa S

    Japanese journal of radiology   Vol. 37 ( 5 ) page: 431-435   2019.5

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    DOI: 10.1007/s11604-019-00828-0

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  260. Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study. Reviewed

    Nao Takano, Suguru Yamada, Akihiro Hirakawa, Yukihiro Yokoyama, Hiroki Kawashima, Osamu Maeda, Tohru Okada, Eizaburo Ohno, Junpei Yamaguchi, Takuya Ishikawa, Fuminori Sonohara, Masaya Suenaga, Hideki Takami, Masamichi Hayashi, Yukiko Niwa, Yoshiki Hirooka, Yoshiyuki Ito, Shinji Naganawa, Yuichi Ando, Masato Nagino, Hidemi Goto, Tsutomu Fujii, Yasuhiro Kodera

    Nagoya journal of medical science   Vol. 81 ( 2 ) page: 233 - 239   2019.5

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    The efficacy of nab-paclitaxel combined with gemcitabine (GnP) and of chemoradiotherapy (CRT) for unresectable locally advanced pancreatic ductal adenocarcinoma (UR-LA PDAC) is still unclear. We previously conducted a phase I study of CRT using GnP and determined the recommended dose and have now designed a phase II trial to evaluate the efficacy of CRT incorporating GnP for UR-LA PDAC. Eligibility criteria are chemotherapy-naïve patients with UR-LA PDAC as defined by the NCCN guidelines version 2. 2016. Study patients will receive 100 mg/m2 nab-paclitaxel and 800 mg/m2 gemcitabine on Days 1, 8, and 15 per 4-week cycle with concurrent radiation therapy (total dose of 50.4 Gy in 28 fractions of 1.8 Gy per day, 5 days per week). Treatment will be continued until disease progression or surgery, which is to be performed only for patients in whom the disease is well-controlled at 8 months from beginning the protocol treatment. Primary endpoint is 2-year overall survival rate and co-primary endpoint is resection rate. Secondary endpoints are overall survival, progression free survival, time to treatment failure, response rate, disease control rate, early tumor shrinkage, depth of response, reduction of SUV-max on PET-CT, serum tumor markers, relative dose intensity, safety, and Quality of life. This study will show the efficacy and safety of chemoradiotherapy combined with GnP.

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  261. 子宮平滑筋肉腫 Reviewed

    櫻井悠介、岩野信吾、長縄慎二、下山芳江、新美 薫

    画像診断   Vol. 39 ( 6 ) page: 512 - 513   2019.5

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  262. 画像診断と病理 食道平滑筋腫

    兵藤 良太, 岩野 信吾, 長縄 慎二, 宮田 一志, 島田 聡子

    画像診断   Vol. 39 ( 7 ) page: 662 - 663   2019.5

  263. Utility of Metabolic Parameters on FDG PET/CT in the Classification of Early-Stage Lung Adenocarcinoma: Prediction of Pathological Invasive Size.

    Iwano S, Ito S, Kamiya S, Ito R, Kato K, Naganawa S

    Clinical nuclear medicine     2019.4

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    DOI: 10.1097/RLU.0000000000002591

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  264. A case of human pancreatic eurytremiasis. Reviewed International journal

    Hiroshi Ogawa, Yasuo Takehara, Shinji Naganawa, Junpei Yamaguchi, Masato Nakaguro

    Abdominal radiology (New York)   Vol. 44 ( 4 ) page: 1213 - 1216   2019.4

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    This study provides the first comprehensive imaging report of human pancreatic eurytremiasis. A 43-year-old man with obstructive jaundice and a pancreatic tumor was referred for diagnosis and treatment. Serum aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase were elevated. Computed tomography (CT) revealed a multilocular cystic lesion with delayed enhanced area in the pancreas head. On magnetic resonance imaging, the tumor was hyperintense on diffusion-weighted image, and the apparent diffusion coefficient value of the tumor was lower than that of the normal pancreatic parenchyma. Positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed tomography (18F-FDG PET/CT) revealed abnormally increased uptake of 18F-FDG in the tumor. A subtotal stomach-preserving pancreaticoduodenectomy was performed on the preoperative diagnosis of pancreatic carcinoma accompanied by branch duct-type intraductal papillary mucinous neoplasm. Multifocal granulomatous lesions with necrotic areas including many parasite eggs were seen on the histology. The final diagnosis was pancreatic eurytremiasis.

    DOI: 10.1007/s00261-019-01925-4

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  265. Clinical Features of Ears With Otosclerosis and Endolymphatic Hydrops.

    Wang F, Yoshida T, Sugimoto S, Shimono M, Teranishi M, Naganawa S, Sone M

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   Vol. 40 ( 4 ) page: 441-445   2019.4

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    DOI: 10.1097/MAO.0000000000002175

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  266. Influence of implanted metals in new CT reconstruction algorithm for radiotherapy treatment planning

    Kamomae T, Nakaya T, Kawabata F, Okudaira K, Kumagai M, Oguchi H, Itoh Y, Naganawa S

    RADIOTHERAPY AND ONCOLOGY   Vol. 133   page: S1132-S1132   2019.4

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  267. 縦隔奇形腫 Reviewed

    中根俊樹、岩野信吾、長縄慎二

    画像診断   Vol. 39 ( 5 ) page: 380 - 381   2019.4

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  268. FDG-PET/CTの腫瘍代謝容積に基づいた肺腺癌の臨床病期診断の試み

    岩野 信吾, 伊藤 倫太郎, 長縄 慎二

    肺癌   Vol. 59 ( 2 ) page: 189 - 189   2019.4

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  269. 7テスラMR装置における高空間分解能3次元位相コントラスト磁気共鳴法を利用した脳血流動態解析の制度検証 Reviewed

    田嶋駿亮、礒田治夫、福永雅喜、長縄慎二

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 平成30年度活動報告書   Vol. - ( - ) page: 24 - 24   2019.3

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  270. 腎静脈に発生した平滑筋肉腫 Invited Reviewed

    松島正哉、林 葉子、岩野信吾、長縄慎二、下山芳江

    画像診断   Vol. 39 ( 3 ) page: 252 - 253   2019.3

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  271. 脳とこころの研究センター長 挨拶 Reviewed

    長縄慎二

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 平成30年度活動報告書   Vol. - ( - ) page: 1 - 1   2019.3

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  272. MRによる血液-脳間質液-脳脊髄液の動態の解明 Reviewed

    長縄慎二、田岡俊昭、川井 恒

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 平成30年度活動報告書   Vol. - ( - ) page: 29 - 30   2019.3

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  273. Quantitative Follow-Up Assessment of Patients with Interstitial Lung Disease by 3D-Curved High-Resolution CT Imaging Parallel to the Chest Wall. Reviewed

    Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Keigo Nakamura, Shinji Naganawa

    Nagoya journal of medical science   Vol. 81 ( 1 ) page: 41 - 53   2019.2

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    We evaluated the progression of interstitial lung disease (ILD) by three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall and compare the results to pulmonary function test (PFT) results on a follow-up assessment. We reviewed the patients with ILD who underwent HRCT and concurrent PFTs at least twice from April 2008 to December 2014. Forty-five patients with ILD were enrolled. 3D-cHRCT images of the lung at various depths from the chest wall were reconstructed, and total area (TA), high-attenuation area (HAA) >-500 HU, and %HAA ([HAA/TA] × 100) were calculated. The TA, HAA, and %HAA ratios (follow-up to baseline) were assessed for use in the diagnosis of physiologically progressive ILD (defined as; forced vital capacity [FVC] ratio <0.9 or %diffusing capacity of the lung for carbon monoxide [%DLCO] ratio <0.85 [follow-up to baseline]). Of all ratios obtained from 3D-cHRCT images at 5-30mm depths, the %HAA ratio at 20-mm had the largest area under the receiver operating characteristic curve (0.815, 95 % confidence interval 0.677-0.953). By univariate logistic regression analysis, TA, HAA, and %HAA ratios at 20-mm showed significant correlations with physiologically progressive ILD. 3D-cHRCT imaging performed in parallel with the chest wall offers novel quantitative parameters that are useful for following ILD.

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  274. パーキンソン病におけるdefault mode network Reviewed

    渡辺宏久、勝野雅央、長縄慎二、祖父江元

    CLINICAL NEUROSCIENCE (月間 臨床神経科学)   Vol. 37 ( 2 ) page: 212 - 216   2019.2

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  275. 膵上皮内腫瘍性病変 Reviewed

    小川 浩、岩野信吾、長縄慎二、中黒匡人

    画像診断   Vol. 39 ( 2 ) page: 142 - 143   2019.2

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  276. 原発性肺癌の術前臨床病期診断の正確性

    岩野 信吾, 馬越 弘泰, 伊藤 倫太郎, 島本 宏矩, 長縄 慎二

    Japanese Journal of Radiology   Vol. 37 ( Suppl. ) page: 25 - 25   2019.2

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  277. イピリムマブに伴う下垂体炎の3例

    加藤 理恵子, 川井 恒, 田岡 俊昭, 長縄 慎二, 岩間 信太郎

    Japanese Journal of Radiology   Vol. 37 ( Suppl. ) page: 25 - 25   2019.2

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  278. Significance of internal auditory canal diverticula in ears with otosclerosis.

    Wang F, Yoshida T, Shimono M, Sugimoto S, Teranishi M, Naganawa S, Sone M

    Acta oto-laryngologica     page: 1-4   2019.1

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    DOI: 10.1080/00016489.2018.1521526

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  279. 画像診断と病理 骨芽細胞腫

    駒田 智大, 岩野 信吾, 長縄 慎二, 新井 英介, 西田 佳弘, 下山 芳江

    画像診断   Vol. 39 ( 1 ) page: 4-5 - 5   2018.12

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  280. Signal Intensity of the Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agents: Strong Contrast Enhancement around the Vein of Labbe.

    Ohashi T, Naganawa S, Ogawa E, Katagiri T, Kuno K

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2018.11

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    DOI: 10.2463/mrms.mp.2018-0043

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  281. Can low b value diffusion weighted imaging evaluate the character of cerebrospinal fluid dynamics?

    Taoka T, Naganawa S, Kawai H, Nakane T, Murata K

    Japanese journal of radiology     2018.11

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    DOI: 10.1007/s11604-018-0790-8

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  282. Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging.

    Naganawa S, Nakane T, Kawai H, Taoka T

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2018.11

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    DOI: 10.2463/mrms.mp.2018-0053

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  283. 2019年 最新医療機器の動向を探る CTおよびMRIなどの画像診断機器の最新潮流ならびに今後のあり方

    長縄慎二

    医療機器システム白書     page: 14-17   2018.11

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  284. Analysis of late adverse events and their chronological changes after radiation therapy for cervical cancer

    Yamada Takehiro, Ishihara Shunichi, Kawai Michiyasu, Itoh Yoshiyuki, Naganawa Shinji, Ikeda Mitsuru

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 4 ) page: 487-496   2018.11

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    DOI: 10.18999/nagjms.80.4.487

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  285. 画像診断レポート未読問題について Reviewed

    長縄慎二

    健康文化   Vol. 53 ( - ) page: 138 - 142   2018.11

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  286. 第三次人工知能ブーム? Reviewed

    長縄慎二

    健康文化   Vol. 53 ( - ) page: 1 - 2   2018.11

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  287. Significance of Endolymphatic Hydrops Herniation Into the Semicircular Canals Detected on MRI.

    Sugimoto S, Yoshida T, Teranishi M, Kobayashi M, Shimono M, Naganawa S, Sone M

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   Vol. 39 ( 10 ) page: 1229-1234   2018.10

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    DOI: 10.1097/MAO.0000000000002022

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  288. Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer's Disease: A PET (THK5351, PiB) and Resting fMRI Study. Reviewed International journal

    Takamasa Yokoi, Hirohisa Watanabe, Hiroshi Yamaguchi, Epifanio Bagarinao, Michihito Masuda, Kazunori Imai, Aya Ogura, Reiko Ohdake, Kazuya Kawabata, Kazuhiro Hara, Yuichi Riku, Shinsuke Ishigaki, Masahisa Katsuno, Shinichi Miyao, Katsuhiko Kato, Shinji Naganawa, Ryuichi Harada, Nobuyuki Okamura, Kazuhiko Yanai, Mari Yoshida, Gen Sobue

    Frontiers in aging neuroscience   Vol. 10   page: 304 - 304   2018.10

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    Background: Imaging studies in Alzheimer's disease (AD) have yet to answer the underlying questions concerning the relationship among tau retention, neuroinflammation, network disruption and cognitive decline. We compared the spatial retention patterns of 18F-THK5351 and resting state network (RSN) disruption in patients with early AD and healthy controls. Methods: We enrolled 23 11C-Pittsburgh compound B (PiB)-positive patients with early AD and 24 11C-PiB-negative participants as healthy controls. All participants underwent resting state functional MRI and 18F-THK5351 PET scans. We used scaled subprofile modeling/principal component analysis (SSM/PCA) to reduce the complexity of multivariate data and to identify patterns that exhibited the largest statistical effects (variances) in THK5351 concentration in AD and healthy controls. Findings: SSM/PCA identified a significant spatial THK5351 pattern composed by mainly three clusters including precuneus/posterior cingulate cortex (PCC), right and left dorsolateral prefrontal cortex (DLPFC) which accounted for 23.6% of the total subject voxel variance of the data and had 82.6% sensitivity and 79.1% specificity in discriminating AD from healthy controls. There was a significant relationship between the intensity of the 18F-THK5351 covariation pattern and cognitive scores in AD. The spatial patterns of 18F-THK5351 uptake showed significant similarity with intrinsic functional connectivity, especially in the PCC network. Seed-based connectivity analysis from the PCC showed significant decrease in connectivity over widespread brain regions in AD patients. An evaluation of an autopsied AD patient with Braak V showed that 18F-THK5351 retention corresponded to tau deposition, monoamine oxidase-B (MAO-B) and astrogliosis in the precuneus/PCC. Interpretation: We identified an AD-specific spatial pattern of 18F-THK5351 retention in the precuneus/PCC, an important connectivity hub region in the brain. Disruption of the functional connections of this important network hub may play an important role in developing dementia in AD.

    DOI: 10.3389/fnagi.2018.00304

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  289. Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain: Observations by Dynamic MRI and Effect of Circadian Rhythm on Tissue Gadolinium Concentrations. Reviewed International journal

    Toshiaki Taoka, Gregor Jost, Thomas Frenzel, Shinji Naganawa, Hubertus Pietsch

    Investigative radiology   Vol. 53 ( 9 ) page: 529 - 534   2018.9

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    OBJECTIVES: The glymphatic system is a recently hypothesized waste clearance system of the brain in which perivascular space constitutes a pathway similar to the lymphatic system in other body regions. Sleep and anesthesia are reported to influence the activity of the glymphatic system. Because rats are nocturnal animals, the glymphatic system is expected to be more active during the day. We attempted to elucidate the influence of the glymphatic system for intravenously injected gadodiamide in the rat brain by 2 experiments. One was a magnetic resonance imaging (MRI) experiment to evaluate the short-term dynamics of signal intensity changes after gadodiamide administration. The other was a quantification experiment to evaluate the concentration of retained gadolinium within the rat brain after repeated intravenous administration of gadodiamide at different times of day and levels of anesthesia. MATERIALS AND METHODS: The imaging experiment was performed on 6 rats that received an intravenous injection of gadodiamide (1 mmol/kg) and dynamic MRI for 3 hours at 2.4-minute intervals. The time course of the signal intensity changes was evaluated for different brain structures. The tissue quantification experiment was performed on 24 rats divided into 4 groups by injection time (morning, late afternoon) and anesthesia (none, short, long) during administration. All animals received gadodiamide (1.8 mmol/kg, 8 times over 2 weeks). Gadolinium concentration of dissected brain tissues was quantified 5 weeks after the last administration by inductively coupled plasma mass spectrometry. RESULTS: In the imaging experiment, muscle and the fourth ventricle showed an instantaneous signal intensity increase immediately after gadodiamide injection. The signal curve of the cerebral cortex and deep cerebellar nuclei reached the peak signal intensity later than the fourth ventricle but earlier than that of the prepontine cistern. In the gadolinium quantification experiment, the concentration in the group with the morning injection showed a significantly lower concentration than the late afternoon injection group. The lowest tissue gadolinium concentrations were found in the groups injected in the morning during long anesthesia. CONCLUSIONS: Instantaneous transition of gadodiamide from blood to cerebrospinal fluid was indicated by dynamic MRI. The gadodiamide distribution to the cerebral cortex and deep cerebellar nuclei seemed to depend on both blood flow and cerebrospinal fluid. This confirms previous studies indicating that the cerebrospinal fluid is one potential pathway of gadolinium-based contrast agent entry into the brain. For the distribution and clearance of the gadodiamide from brain tissue, involvement of the glymphatic system seemed to be indicated in terms of the influence of sleep and anesthesia.

    DOI: 10.1097/RLI.0000000000000473

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  290. Generative Adversarial Networkを用いた肺結節の画像生成について

    伊藤 倫太郎, 岩野 信吾, 長縄 慎二

    日本医学放射線学会秋季臨床大会抄録集   Vol. 54回   page: S561 - S561   2018.9

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  291. Histogram analysis of quantitative pharmacokinetic parameters on DCE-MRI: correlations with prognostic factors and molecular subtypes in breast cancer.

    Nagasaka K, Satake H, Ishigaki S, Kawai H, Naganawa S

    Breast cancer (Tokyo, Japan)     2018.8

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    DOI: 10.1007/s12282-018-0899-8

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  292. Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer. Reviewed

    Shinji Ito, Shingo Iwano, Katsuhiko Kato, Shinji Naganawa

    Annals of nuclear medicine   Vol. 32 ( 6 ) page: 418 - 424   2018.7

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    OBJECTIVE: To identify prognostic factors associated with a low-iodine diet (LID) and the amount of remnant thyroid tissue in Japanese patients with differentiated thyroid cancer (DTC) who received initial I-131 remnant ablation (RAI) using a fixed low dose of I-131 (1110 MBq). PATIENTS AND METHODS: In this prospective study, we enrolled 45 patients. Patients were classified into a self-managed LID group and a strict LID group. We measured the urinary iodine concentration on the day of RAI after patients consumed LID for 2 weeks. Thyroid-stimulating hormone-induced thyroglobulin (Tg) levels and I-131 uptake by the remnant thyroid tissue were also evaluated. A response-evaluation whole-body scan (WBS) was performed 6-8 months after RAI to determine the outcome of the therapy. RESULTS: Post-LID urinary iodine levels of the strict LID group tended to be lower than those of the self-managed LID group. Twenty-five cases (56%) showed absence of uptake, whereas 20 cases (44%) showed residual uptake on the response-evaluation WBS. There were no significant differences between "absence" and "residual" groups in urinary iodine concentrations and Tg levels (p = 0.253 and p = 0.234, respectively). However, significant differences were observed in I-131 uptake by the thyroid bed (p = 0.035). CONCLUSIONS: For patients following the current Japanese method of a 2-week LID, the urinary iodine concentration was not a predictive factor for the successful outcome of RAI. In contrast, low I-131 uptake by the thyroid bed, revealed by the scintigram after RAI, may serve as a favorable predictive factor.

    DOI: 10.1007/s12149-018-1261-0

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  293. 【膵癌update】 診断 MRI/MRCP

    小川 浩、竹原康雄、長縄慎二

    臨床消化器内科   Vol. 33 ( 7 ) page: 789-793   2018.7

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  294. Myocardial motion analysis based on an optical flow method using tagged MR images. Reviewed

    Daiki Tabata, Haruo Isoda, Kaori Kato, Hiroki Matsubara, Takafumi Kosugi, Takashi Kosugi, Masaki Terada, Atsushi Fukuyama, Yoshiaki Komori, Shinji Naganawa

    Radiological physics and technology   Vol. 11 ( 2 ) page: 202 - 211   2018.6

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    We developed a method of velocimetry based on an optical flow method using quantitative analyses of tagged magnetic resonance (MR) images (tagged MR-optical flow velocimetry, tMR-O velocimetry). The purpose of our study was to examine the accuracy of measurement of the proposed tMR-O velocimetry. We performed retrospective pseudo-electrocardiogram (ECG) gating tagged cine MR imaging on a rotating phantom. We optimized imaging parameters for tagged MR imaging, and validated the accuracy of tMR-O velocimetry. Our results indicated that the difference between the reference velocities and the computed velocities measured using optimal imaging parameters was less than 1%. In addition, we performed tMR-O velocimetry and echocardiography on 10 healthy volunteers, for four sections of the heart (apical, midventricular, and basal sections aligned with the short-axis, and a four-chamber section aligned with the long-axis), and obtained radial and longitudinal myocardial velocities in these sections. We compared the myocardial velocities obtained using tMR-O velocimetry with those obtained using echocardiography. Our results showed good agreement between tMR-O velocimetry and echocardiography in the radial myocardial velocities in three short-axial sections and longitudinal myocardial velocities on the midventricular portion of the four-chamber section in the long-axis. In the study conducted on the rotating phantom, tMR-O velocimetry showed high accuracy; moreover, in the healthy volunteers, the myocardial velocities obtained using tMR-O velocimetry were relatively similar to those obtained using echocardiography. In conclusion, tMR-O velocimetry is a potentially feasible method for analyzing myocardial motion in the human heart.

    DOI: 10.1007/s12194-018-0456-3

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  295. Inter-individual Comparison of Gadobutrol and Gadoteridol Tissue Time-intensity Profiles for Dynamic Susceptibility Contrast Perfusion MR Imaging.

    Yamada M, Taoka T, Kawaguchi A, Yasuda K, Niinomi Y, Ohashi Y, Okuda T, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2018.5

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    DOI: 10.2463/mrms.mp.2017-0172

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  296. Diagnostic performance of <sup>18</sup>F-FDG PET/CT and whole-body diffusion-weighted imaging with background body suppression (DWIBS) in detection of lymph node and bone metastases from pediatric neuroblastoma.

    Ishiguchi H, Ito S, Kato K, Sakurai Y, Kawai H, Fujita N, Abe S, Narita A, Nishio N, Muramatsu H, Takahashi Y, Naganawa S

    Annals of nuclear medicine     2018.4

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    DOI: 10.1007/s12149-018-1254-z

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  297. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan.

    Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Wakabayashi T, Kuzuya M, Ozaki N, Hoshiyama M, Isoda H, Naganawa S, Sobue G

    NeuroImage   Vol. 169   page: 134 - 144   2018.4

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    DOI: 10.1016/j.neuroimage.2017.12.014

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  298. Tau Kinetics in Neurons and the Human Central Nervous System

    Sato Chihiro, Barthelemy Nicolas R., Mawuenyega Kwasi G., Patterson Bruce W., Gordon Brian A., Jockel-Balsarotti Jennifer, Sullivan Melissa, Crisp Matthew J., Kasten Tom, Kirmess Kristopher M., Kanaan Nicholas M., Yarasheski Kevin E., Baker-Nigh Alaina, Benzinger Tammie L. S., Miller Timothy M., Karch Celeste M., Bateman Randall J.

    NEURON   Vol. 97 ( 6 ) page: 1284 - +   2018.3

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    DOI: 10.1016/j.neuron.2018.02.015

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  299. Computer-aided Volumetry of Part-Solid Lung Cancers by Using CT: Solid Component Size Predicts Prognosis.

    Kamiya S, Iwano S, Umakoshi H, Ito R, Shimamoto H, Nakamura S, Naganawa S

    Radiology     page: 172319   2018.3

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    DOI: 10.1148/radiol.2018172319

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  300. Improved 3D-real Inversion Recovery: A Robust Imaging Technique for Endolymphatic Hydrops after Intravenous Administration of Gadolinium.

    Naganawa S, Kawai H, Taoka T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2018.3

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    DOI: 10.2463/mrms.bc.2017-0158

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  301. Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease.

    Kawabata K, Watanabe H, Hara K, Bagarinao E, Yoneyama N, Ogura A, Imai K, Masuda M, Yokoi T, Ohdake R, Tanaka Y, Tsuboi T, Nakamura T, Hirayama M, Ito M, Atsuta N, Maesawa S, Naganawa S, Katsuno M, Sobue G

    Journal of neurology   Vol. 265 ( 3 ) page: 688-700   2018.3

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    DOI: 10.1007/s00415-018-8755-5

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  302. Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease

    Kawabata Kazuya, Watanabe Hirohisa, Hara Kazuhiro, Bagarinao Epifanio, Yoneyama Noritaka, Ogura Aya, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ohdake Reiko, Tanaka Yasuhiro, Tsuboi Takashi, Nakamura Tomohiko, Hirayama Masaaki, Ito Mizuki, Atsuta Naoki, Maesawa Satoshi, Naganawa Shinji, Katsuno Masahisa, Sobue Gen

    JOURNAL OF NEUROLOGY   Vol. 265 ( 3 ) page: 688-700   2018.3

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    DOI: 10.1007/s00415-018-8755-5

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  303. 特集 脳脊髄液動態のすべて 脳脊髄液による老廃物のクリアランス―glymphaticシステム―

    田岡俊昭、長縄慎二

    画像診断   Vol. 38 ( 3 ) page: 268-276   2018.3

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  304. MR画像による脳内の物質輸送機構の解明

    長縄慎二、田岡俊昭、川井 恒

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成   平成29年度活動報告書     page: 25-26   2018.3

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  305. 脳とこころの研究センター長 挨拶

    長縄慎二

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成   平成29年度活動報告書     page: 1   2018.3

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  306. 後下小脳動脈抹消部動脈瘤の診断におけるthin slab MIP法の有用性

    長縄慎二

    日本脳神経CI学会機関誌   Vol. 39 ( 3-4 ) page: 121-130   2018.3

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  307. Patients with anti-thyroid antibodies are prone to develop destructive thyroiditis by nivolumab: a prospective study Reviewed

    Tomoko Kobayashi, Shintaro Iwama, Yoshinori Yasuda, Norio Okada, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita, Motomitsu Goto, Hidetaka Suga, Ryoichi Banno, Kenji Yokota, Tetsunari Hase, Masahiro Morise, Naozumi Hashimoto, Masahiko Ando, Hitoshi Kiyoi, Momokazu Gotoh, Yuichi Ando, Masashi Akiyama, Yoshinori Hasegawa, Hiroshi Arima

    Journal of the Endocrine Society     2018.2

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    DOI: 10.1210/js.2017-00432

  308. Imaging of the endolymphatic space in patients with Ménière's disease. Reviewed International journal

    Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Hironao Otake, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

    Auris, nasus, larynx   Vol. 45 ( 1 ) page: 33 - 38   2018.2

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    OBJECTIVE: To examine endolymphatic hydrops (EH) using magnetic resonance imaging (MRI) in patients with definite Ménière's disease (MD) and those with nonotological diseases. METHODS: We studied 32 patients with unilateral MD, 10 patients with bilateral MD and 21 patients with control ears who had other benign diseases not associated with hearing or vestibular dysfunction. The mean age of the subjects was 54.0 years (range 27-74) in the MD group and 56.1 years (range 24-79) in the control group. Using MRI, the degree of EH was classified as none, mild and significant in the cochlea and vestibule separately. The ratio of the area of endolymphatic space to the vestibular fluid space was calculated for the vestibule. The duration of MD was defined as the months between the first attack of MD and the MRI study. RESULTS: EH was present in the cochlea of 45/52 affected ears of patients with MD (87%) and in 16/42 control ears (38%). Significant cochlear hydrops was present in 37/52 affected ears (71%) and in 4/42 control ears (10%). EH in the vestibule was present in 49/52 affected ears (94%) and in 3/42 control ears (7%). Significant vestibular hydrops was present in 40/52 affected ears (77%) and in none of the 42 control ears. There was no relationship between the degree of EH and its duration. Using a cut off value for the relative size of EH in the vestibule of 41.9%, the test had a sensitivity of 88.5% and a specificity of 100% to diagnose definite MD. CONCLUSION: Cochlear EH was occasionally observed in control ears on MRI, as in normal temporal bone specimens. The presence or absence and degree of vestibular EH were significantly different between ears with MD and control ears. EH in the vestibule might be a specific predictor of definite MD.

    DOI: 10.1016/j.anl.2017.02.002

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  309. 早期声門癌に対するS-1併用化学放射線療法の長期成績

    高瀬 裕樹, 伊藤 善之, 木村 香菜, 岡田 徹, 久保田 誠司, 川村 麻里子, 中原 理絵, 大家 祐実, 香西 由加, 長縄 慎二, 藤本 保志, 曾根 三千彦

    Japanese Journal of Radiology   Vol. 36 ( Suppl. ) page: 22 - 22   2018.2

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  310. 胸壁並行断面CTを用いた間質性肺炎の経時的評価

    馬越 弘泰, 岩野 信吾, 伊藤 倫太郎, 島本 宏矩, 長縄 慎二

    Japanese Journal of Radiology   Vol. 36 ( Suppl. ) page: 19 - 19   2018.2

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  311. 非小細胞肺癌の局所浸潤性の予測に関する造影dual energy CTとFDG-PET/CTの比較

    伊藤 倫太郎, 岩野 信吾, 島本 宏矩, 馬越 弘泰, 伊藤 信嗣, 長縄 慎二, 加藤 克彦

    Japanese Journal of Radiology   Vol. 36 ( Suppl. ) page: 20 - 20   2018.2

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  312. 【脳脊髄液動態のすべて】脳脊髄液による老廃物のクリアランス glymphaticシステム

    田岡 俊昭, 長縄 慎二

    画像診断   Vol. 38 ( 3 ) page: 268 - 276   2018.2

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    glymphaticシステムは頭蓋内の脳脊髄液,脳内の間質液を含む循環に関連した1つのコンセプトであり,脳実質内の老廃物を洗い出すシステムとして広く受け入れられるようになりつつある.その一方で,以前から提唱されている細小動脈壁の排出路を介したシステムとの関連も含めて,この仮説に関して不明な点も多く,現時点で多くの議論がある.(著者抄録)

    Other Link: https://search.jamas.or.jp/default/link?pub_year=2018&ichushi_jid=J00235&link_issn=&doc_id=20180226160007&doc_link_id=10.15105%2FGZ.0000000353&url=https%3A%2F%2Fdoi.org%2F10.15105%2FGZ.0000000353&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  313. Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio. Reviewed

    Toshio Ohashi, Shinji Naganawa, Toshio Katagiri, Kayao Kuno

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 17 ( 1 ) page: 67 - 72   2018.1

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    PURPOSE: We routinely obtain the endolymphatic hydrops (EH) image using heavily T2-weighted three dimensional-fluid attenuated inversion recovery (hT2w-3D-FLAIR) imaging at 4 hours after intravenous administration of a single-dose of gadolinium-based contrast media (IV-SD-GBCM). While repeating the examination, we speculated that the contrast enhancement of the perivascular space (PVS) in the basal ganglia might be related to the degree of EH. Therefore, the purpose of this study was to investigate the relationship between the endolymphatic volume ratio (%ELvolume) and the signal intensity of the PVS (SI-PVS). MATERIALS AND METHODS: In 20 patients with a suspicion of EH, a heavily T2-weighted 3D-turbo spin echo sequence for MR cisternography (MRC) and an hT2w-3D-FLAIR as a positive perilymph image (PPI) were obtained at 4 hours after IV-SD-GBCM. The %ELvolume of the cochlea and the vestibule were measured on the previously reported HYDROPS2-Mi2 image. The PVS in the basal ganglia was segmented on MRC using a region-growing method. The PVS regions were copied and pasted onto the PPI, and the SI-PVS was measured. The larger value of the right and the left ears was employed as the %ELvolume, and the weighted average of both sides was employed as the SI-PVS. The correlation between the %ELvolume and the SI-PVS was evaluated. RESULT: There was a strong negative linear correlation between the %ELvolume of the cochlea and the SI-PVS (r = -0.743, P < 0.001); however, there was no significant correlation between the %ELvolume of the vestibule and the SI-PVS (r = -0.267, P = 0.256). CONCLUSION: There was a strong negative correlation between the cochlear %ELvolume and the SI-PVS. Contrast enhancement of PVS might be a biomarker of EH.

    DOI: 10.2463/mrms.mp.2017-0001

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  314. Gadolinium-based Contrast Media, Cerebrospinal Fluid and the Glymphatic System: Possible Mechanisms for the Deposition of Gadolinium in the Brain. Reviewed

    Toshiaki Taoka, Shinji Naganawa

    Magn Reson Med Sci.     2018.1

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    DOI: 10.2463/mrms.rev.2017-0116.

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  315. FDG PET/CT Overcomes Discordance Between Clinical and Pathologic TNM Classification of Small-size Primary Lung Cancer: Influence on Postoperative Prognosis. Reviewed International journal

    Hiroyasu Umakoshi, Shingo Iwano, Kohei Yokoi, Shinji Ito, Rintaro Ito, Koji Kawaguchi, Takayuki Fukui, Shinji Naganawa

    Clinical lung cancer   Vol. 19 ( 1 ) page: e37-e45 - e45   2018.1

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    INTRODUCTION: We aimed to determine the concordance between the clinical stage (c-stage) and pathologic stage (p-stage) for patients with small-size lung cancer. Additionally we searched for prognostic factors other than the TNM stage. PATIENTS AND METHODS: We retrospectively reviewed the preoperative multidetector computed tomography (CT) and positron emission tomography/CT reports, surgical records, and pathologic reports of patients with primary lung cancer ≤ 3 cm. The Union for International Cancer Control TNM seventh edition classification of c-stage and p-stage were compared. The tumors were classified into multiple subgroups by concordance or discordance between the c-stage and p-stage. Disease-free survival (DFS) was assessed using survival analysis to assess the tumor characteristics that were predictive of prognosis. RESULTS: A total of 289 surgically resected primary lung cancers were evaluated. The concordance between c-stage and p-stage was 65.4%, with moderate reproducibility (kappa coefficient, 0.467). The upstaging rate from c-stage I to p-stage II-IV was 9.4%, and these patients had significantly worse DFS than those with a concordant stage I classification (P < .001). The main reason for upstaging was an underestimation of metastases to the hilar lymph nodes (n = 7) or mediastinal lymph nodes (n = 11). A multivariate Cox proportional hazards model showed that the significant predictive factors for DFS were p-stage (hazard ratio, 1.342; P = .003) and maximum standardized uptake value on positron emission tomography/CT (hazard ratio, 12.162; P = .001). CONCLUSION: The concordance rate between c-stage and p-stage for small primary lung cancers had moderate reproducibility. Discordance between c-stage I and p-stage II-IV significantly affected DFS. The maximum standardized uptake value of the primary lesion was an independent prognostic factor, and combining it with c-stage might improve the prediction of therapeutic outcomes.

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  316. Differences in Signal Intensity and Enhancement on MR Images of the Perivascular Spaces in the Basal Ganglia versus Those in White Matter

    Naganawa Shinji, Nakane Toshiki, Kawai Hisashi, Taoka Toshiaki

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 17 ( 4 ) page: 301-307   2018

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    DOI: 10.2463/mrms.mp.2017-0137

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  317. Clinical MR imaging of endolymphatic hydrops: Updates on scanning methods, image processing and interpretation. Reviewed

    Shinji Naganwa

    Solutions in Contrast Imaging.   Vol. 9 ( 5 ) page: 1-5   2018

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  318. Dosimetric feasibility of using tungsten-based functional paper for flexible chest wall protectors in intraoperative electron radiotherapy for breast cancer. Reviewed International journal

    Takeshi Kamomae, Hajime Monzen, Mariko Kawamura, Kuniyasu Okudaira, Takayoshi Nakaya, Takashi Mukoyama, Yoshikazu Miyake, Yoshitomo Ishihara, Yoshiyuki Itoh, Shinji Naganawa

    Physics in medicine and biology   Vol. 63 ( 1 ) page: 015006 - 015006   2017.12

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    Intraoperative electron radiotherapy (IOERT), which is an accelerated partial breast irradiation method, has been used for early-stage breast cancer treatment. In IOERT, a protective disk is inserted behind the target volume to minimize the dose received by normal tissues. However, to use such a disk, the surgical incision must be larger than the field size because the disk is manufactured from stiff and unyielding materials. In this study, the applicability of newly developed tungsten-based functional paper (TFP) was assessed as an alternative to the existing protective disk. The radiation-shielding performance of the TFP was verified through experimental measurements and Monte Carlo simulations. Percentage depth dose curves and lateral dose profiles with and without TFPs were measured and simulated on a dedicated IOERT accelerator. The number of piled-up TFPs was changed from 1 to 40. In the experimental measurements, the relative doses at the exit plane of the TFPs for 9 MeV were 42.7%, 9.2%, 0.2%, and 0.1% with 10, 20, 30, and 40 TFPs, respectively, whereas those for 12 MeV were 63.6%, 27.1%, 8.6%, and 0.2% with 10, 20, 30, and 40 TFPs, respectively. Slight dose enhancements caused by backscatter radiation from the TFPs were observed at the entrance plane of the TFPs at both beam energies. The results of the Monte Carlo simulation indicated the same tendency as the experimental measurements. Based on the experimental and simulated results, the radiation-shielding performances of 30 TFPs for 9 MeV and 40 TFPs for 12 MeV were confirmed to be acceptable and close to those of the existing protective disk. The findings of this study suggest the feasibility of using TFPs as flexible chest wall protectors in IOERT for breast cancer treatment.

    DOI: 10.1088/1361-6560/aa96cf

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  319. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan. Reviewed

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshihiko Wakabayashi, Masafumi Kuzuya, NorioOzaki, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Gen Sobue

    Neuroimage   ( 169 ) page: 134-144   2017.12

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  320. Longitudinal up-regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment. Reviewed International journal

    Munehisa Fukushima, Tadashi Kitahara, Ryohei Oya, Shiro Akahani, Hidenori Inohara, Shinji Naganawa, Noriaki Takeda

    Laryngoscope investigative otolaryngology   Vol. 2 ( 6 ) page: 344 - 350   2017.12

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    Objective/Hypothesis: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Study Design: Prospective, single-arm repeated measures. Methods: Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months. Results: The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level. Conclusion: EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period. Level of Evidence: 2b.

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  321. 【中枢神経系の新たな疾患カテゴリーとその画像所見】Glymphaticシステム 脳内の老廃物排除のための仕組み

    田岡 俊昭, 長縄 慎二

    臨床画像   Vol. 33 ( 12 ) page: 1447 - 1458   2017.12

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    Glymphaticシステムは頭蓋内の脳脊髄液、脳内の間質液を含む循環に関連した1つのコンセプトであり、脳脊髄液の循環に関しての新しい考え方とともに広く受け入れられるようになりつつあり、さまざまな疾患と関連している可能性が指摘されている。(著者抄録)

    Other Link: https://search.jamas.or.jp/default/link?pub_year=2017&ichushi_jid=J01843&link_issn=&doc_id=20171201080008&doc_link_id=%2Fap4ringc%2F2017%2F003312%2F009%2F1447-1458%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fap4ringc%2F2017%2F003312%2F009%2F1447-1458%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  322. The Relationship Between Endolymphatic Hydrops in the Vestibule and Low-Frequency Air-Bone Gaps. Reviewed

    Satofumi Sugimoto, Tadao Yoshida, Masaaki Teranishi, Yuriko Okazaki, Shinji Naganawa, Michihiko Sone

    The Laryngoscope.   Vol. 28 ( 7 ) page: 1658 - 1662   2017.11

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    DOI: 10.1002/lary.26898.

  323. Letter to editor [Saccular measurements in routine MRI can predict hydrops in Meniele disease] by Simon F et al.

    Pablo Dominguez, Shinji Naganawa

    Eur Arch Otorhinolaryngol.     2017.11

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    DOI: 10.1007/s00405-017-4794-2

  324. Structural MRI correlates of amyotrophic lateral sclerosis progression. Reviewed International journal

    Joe Senda, Naoki Atsuta, Hirohisa Watanabe, Epifanio Bagarinao, Kazunori Imai, Daichi Yokoi, Yuichi Riku, Michihito Masuda, Ryoichi Nakamura, Hazuki Watanabe, Mizuki Ito, Masahisa Katsuno, Shinji Naganawa, Gen Sobue

    Journal of neurology, neurosurgery, and psychiatry   Vol. 88 ( 11 ) page: 901 - 907   2017.11

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    PURPOSE: Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical course and progression of ALS varies widely. Brain degeneration detected using structural MRI could reflect disease progression. SUBJECTS AND METHODS: On study registration, 3-Tesla volumetric MRI and diffusion tensor imaging scans were obtained at baseline in 38 healthy controls and 67 patients with sporadic ALS. Patients had Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) scores of ≥36 and did not have the chromosome 9, open reading frame 72 repeat expansion. Six months later, changes in ALSFRS-R (ΔALSFRS-R) scores were calculated and patients were grouped into three categories, namely, patients with slow progression with ΔALSFRS-R scores ≤3 (n=19), intermediate progression with ΔALSFRS-R scores =4, 5 and 6 (n=36) and rapid progression with ΔALSFRS-R scores ≥7 (n=12). We analysed voxel-based morphometry and tract-based spatial statistics among these subgroups and controls. RESULTS: In comparison with controls, patients with ALS showed grey matter atrophy and decreased fractional anisotropy beyond the motor cortex and CST, especially in the frontotemporal lobes and basal ganglia. Moreover, the degree of change was highly proportional to ΔALSFRS-R at the 6-month assessment. CONCLUSION: A more rapid disease progression and poorer functional decline were associated with greater involvement of the extra-motor cortex and basal ganglia, suggesting that the spatial extent of brain involvement can be an indicator of the progression in ALS.

    DOI: 10.1136/jnnp-2016-314337

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  325. 【局所進行膵癌の治療限界に挑む】局所進行膵癌の術前治療後の画像診断

    小川 浩, 鈴木 耕次郎, 竹原 康雄, 長縄 慎二

    胆と膵   Vol. 38 ( 11 ) page: 1255 - 1260   2017.11

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    膵癌は、血管浸潤の範囲と遠隔転移・腹膜播種の有無により、切除可能、切除境界、切除不能に分類される。このうち、局所進行膵癌である切除境界および切除不能膵癌に関しては、化学療法あるいは化学放射線療法により癌細胞が減少し、外科的切除が可能となる症例が存在する。膵癌の治療効果判定は、CTやMRI、PETといった画像や、CA19-9などの腫瘍マーカーの推移でみるのが一般的である。ここでは、とくに局所進行膵癌の術前治療後の画像診断について述べ、さらに化学放射線療法後に生じる多彩な画像上の変化についても言及する。(著者抄録)

  326. The retention pattern of THK5351 pet imaging and functional network disruption associated with development of Alzheimer's disease

    Yokoi T, Watanabe H, Yamaguchi H, Bagarinao E, Masuda M, Imai K, Ogura A, Ohdake R, Kawabata K, Hara K, Riku Y, Ishigaki S, Katsuno M, Kato K, Naganawa S, Okamura N, Miyao S, Yanai K, Sobue G

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page: 960 - 961   2017.10

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    DOI: 10.1016/j.jns.2017.08.2705

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  327. Improved HYDROPS: Imaging of Endolymphatic Hydrops after Intravenous Administration of Gadolinium. Reviewed

    Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 16 ( 4 ) page: 357 - 361   2017.10

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    To improve the imaging protocol for the evaluation of endolymphatic hydrops after intravenous administration of a gadolinium-based contrast agent, we modified our previously reported hybrid of reversed image of positive endolymph signal and native image of positive perilymph signal (HYDROPS) method. Although the scan time of the new protocol was half that of the previous one, there were no significant differences between two protocols in the mean contrast noise ratio between the endolymph and perilymph and the area ratio of the endolymph size values in nine patients.

    DOI: 10.2463/mrms.tn.2016-0126

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  328. Improved HYDROPS: Imaging of Endolymphatic Hydrops after Intravenous Administration of Gadolinium. Reviewed

    Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Michihiko Sone

    Magn Reson Med Sci.   ( 16 ) page: 357-361   2017.10

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  329. Three-dimensional printer-generated patient-specific phantom for artificial in vivo dosimetry in radiotherapy quality assurance. Reviewed

    Takeshi Kamomae, Hidetoshi Shimizu, Takayoshi Nakaya, Kuniyasu Okudaira, Takahiro Aoyama, Hiroshi Oguchi, Masataka Komori, Mariko Kawamura, Kazuhiro Ohtakara, Hajime Monzen, Yoshiyuki Itoh, Shinji Naganawa

    Phys Med.     2017.10

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    DOI: 10.1016/j.ejmp.2017.10.005.

  330. Longitudinal Up-Regulation of Endolymphatic Hydrops in Patients with Meniere's Disease During Medical Treatment. Reviewed

    Munehisa Fukushima, Tadashi Kitahara, Ryohei Oya, Shiro Akahani, Hidenori Inohara, Shinji Naganawa, Noriaki Takeda

    Laryngoscope Investigative Otolaryngology.   Vol. - ( - )   2017.10

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  331. A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological invasiveness of non-small cell lung cancer. Reviewed International journal

    Rintaro Ito, Shingo Iwano, Hironori Shimamoto, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Ito, Katsuhiko Kato, Shinji Naganawa

    European journal of radiology   Vol. 95   page: 186 - 191   2017.10

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    PURPOSE: To compare dual-phase dual-energy CT (DE-CT) with FDG-PET/CT for predicting histopathological locoregional invasiveness of non-small cell lung cancers (NSCLCs). MATERIALS AND METHODS: We selected 63 consecutive patients with NSCLC lesions (37 males, 26 females; age range, 44-85 years; mean age, 69 years) who were evaluated preoperatively by both DE-CT and PET/CT at our institution. Postoperative microscopic invasiveness (lymphatic permeation, vascular invasion, and/or pleural involvement) was reviewed, and we defined locoregionally invasive tumors as those that had at least one positive finding of microscopic invasiveness. DE-CT scanning in the arterial and delayed phases was performed after injection of iodinated contrast media using 140-kVp and 80-kVp tube voltages. Three-dimensional iodine-related attenuation of primary tumors in the arterial and delayed phases was quantified automatically using "syngo Dual Energy Lung Nodules" application software, and the ratio of arterial phase to delayed phase enhancement (A/D ratio) was calculated. The A/D ratio and SUVmax on PET/CT were evaluated with respect to postoperative invasiveness by univariate logistic regression analysis. RESULTS: The A/D ratio was significantly correlated with lymphatic permeation, vascular invasion, and pleural involvement (p=0.011, p=0.021, and p=0.010, respectively). In contrast, the SUVmax was significantly correlated with pleural involvement (p=0.020) but not with lymphatic permeation or vascular invasion (p=0.088 and p=0.100, respectively). In the subgroup of patients with lesion diameters ≤2cm, the A/D ratio was significantly correlated with locoregional invasiveness (p=0.040), while the SUVmax was not (p=0.121). CONCLUSION: For the prediction of microscopic invasiveness of NSCLCs, the diagnostic performance of dual-phase DE-CT may be comparable to that of FDG-PET/CT.

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  332. ちょっと気になる胆・膵画像 ティーチングファイルから(第36回) 主膵管内腫瘍栓を呈した腺房細胞癌の1例

    小川 浩, 竹原 康雄, 館 靖, 長縄 慎二, 鈴木 耕次郎, 廣岡 芳樹, 山田 豪, 藤井 努, 下山 芳江

    胆と膵   Vol. 38 ( 10 ) page: 1131 - 1134   2017.10

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  333. Appearance of the Organum Vasculosum of the Lamina Terminalis on Contrast-enhanced MR Imaging.

    Naganawa S, Taoka T, Kawai H, Yamazaki M, Suzuki K

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2017.9

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    DOI: 10.2463/mrms.mp.2017-0088

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  334. Clinical usefulness of MLCs in robotic radiosurgery systems for prostate SBRT. Reviewed

    Masashi Tomida, Takeshi Kamomae, Junji Suzuki, Yoichi Ohashi, Yoshiyuki Itoh, Hiroshi Oguchi, Takahito Okuda

    J Appl Clin Med Phys.   Vol. 18 ( 5 ) page: 124-133   2017.9

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  335. Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall: A pilot study. Reviewed

    Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    PLoS One.   Vol. 12 ( 9 ) page: e0185532.   2017.9

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  336. Letter to Editors: Detection of endolymphatic hydrops using traditional MR imaging sequences

    Shinji Naganawa, Michihiko Sone

    American Journal of Otolaryngology - Head and Neck Medicine and Surgery   Vol. 38 ( 5 ) page: 637 - 638   2017.9

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    DOI: 10.1016/j.amjoto.2017.06.014

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  337. Significance of Endolymphatic Hydrops in Ears With Unilateral Sensorineural Hearing Loss. International journal

    Yuriko Okazaki, Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Ken Kato, Shinji Naganawa, Michihiko Sone

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   Vol. 38 ( 8 ) page: 1076 - 1080   2017.9

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    OBJECTIVE: The purpose of this study was to investigate the existence of endolymphatic hydrops (EH) in affected and unaffected ears in patients with unilateral sensorineural hearing loss (SNHL) using contrast-enhanced magnetic resonance imaging (MRI), and to evaluate the significance of EH in various otological diseases. STUDY DESIGN: Retrospective study. SETTING: University hospital. METHODS: One hundred eighty-two ears from 91 patients with unilateral SNHL were studied. The endolymphatic space was evaluated using 3-Tesla MRI with gadodiamide hydrate. Imaging data about the degree of EH in the cochlea and vestibule were analyzed and compared between ears with various otological diseases. RESULTS: All affected ears with delayed endolymphatic hydrops had EH. In affected ears with definite Menière's disease, cochlear EH was observed in all ears and vestibular EH in 93% of ears, and these rates were significantly higher in the affected than in the unaffected ears. EH was also observed in the cochlea and vestibule in 66% and 41%, respectively, of the affected ears with idiopathic sudden SNHL; however, these percentages did not differ significantly from those in the unaffected ears (52% and 38%, respectively). CONCLUSION: MRI showed that a high percentage of ears affected by Menière's disease or delayed endolymphatic hydrops had EH. Further studies should evaluate the implications of EH in ears, especially in those with sudden SNHL, in terms of secondary or pre-existing EH.

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  338. A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological invasiveness of non-small cell lung cancer. Reviewed

    Rintaro Ito, Shingo Iwano, Hironori Shimamoto, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Ito, Katsuhiko Kato, Shinji Naganawa

    European Journal of Radiology.   ( 95 ) page: 186-191   2017.8

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  339. Optimized treatment strategy of radiotherapy for early glottic squamous cell carcinomas: An initial analysis. Reviewed

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Seiji Kubota, Mariko Kawamura, Rie Nakahara, Yumi Oie, Yuka Kozai, Yuuki Takase, Hidenori Tsuzuki, Naoki Nishio, Mariko Hiramatsu, Yasushi Fujimoto, Takefumi Mizutani, Shinji Naganawa

    Nagoya J Med Sci.   Vol. 79 ( 3 ) page: 331-338   2017.8

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  340. Optimized treatment strategy of radiotherapy for early glottic squamous cell carcinomas: An initial analysis. Reviewed

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Seiji Kubota, Mariko Kawamura, Rie Nakahara, Yumi Oie, Yuka Kozai, Yuuki Takase, Hidenori Tsuzuki, Naoki Nishio, Mariko Hiramatsu, Yasushi Fujimoto, Takefumi Mizutani, Shinji Naganawa

    Nagoya journal of medical science   Vol. 79 ( 3 ) page: 331 - 338   2017.8

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    The purpose of this study was to evaluate the clinical outcomes of radiotherapy for patients with T1/T2 glottic carcinoma. Patients with T1/T2 glottic carcinoma histopathologically diagnosed with squamous cell carcinoma and treated at our hospital between 2007 and 2015 were analyzed retrospectively. Our strategy for T1/T2 glottic carcinoma was as follows: radiotherapy alone with 2.25 Gy per fraction to a total of 25-28 fractions for patients with non-bulky T1 glottic carcinoma; concurrent chemoradiotherapy with oral S-1 and radiotherapy with 2 Gy per fraction to a total of 30 fractions for patients with T1 bulky/T2 favorable glottic carcinoma; or chemoradiotherapy with high-dose cisplatin and radiotherapy with 2 Gy per fraction to a total of 35 fractions for T2 unfavorable glottic carcinoma. Forty-eight patients were eligible. The median follow-up period among surviving patients was 38 months (range, 11-107). The disease was T1a in 23%, T1b in 13%, and T2 in 65% of patients. The 3-year local control rate in all patients, T1a, T1b, and T2 was 96.7%, 100%, 100%, and 96.0%, respectively. Of the 46 patients, one with T2 glottic carcinoma developed recurrent disease at the primary site, and one with T2 glottic carcinoma had lymph node recurrences in the neck. Acute Grade 3 dermatitis occurred in 8 (17%) patients and late Grade 2 hypothyroidism occurred in 2 (4%) patients. This retrospective study shows that our optimized treatment strategy of radiotherapy depending on the stage of early glottic carcinoma is not only effective but also well-tolerated.

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  341. FDG-PET/CT predicts survival and lung metastasis of hypopharyngeal cancer in a multi-institutional retrospective study. Reviewed

    Hidenori Suzuki, Katsuhiko Kato, Masami Nishio, Tsuneo Tamaki, Yasushi Fujimoto, Mariko Hiramatsu, Nobuhiro Hanai, Takeshi Kodaira, Yoshiyuki Itoh, Shinji Naganawa, Michihiko Sone, Yasuhisa Hasegawa

    Annals of nuclear medicine   Vol. 31 ( 7 ) page: 514 - 520   2017.8

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    OBJECTIVES: We investigated a possible correlation between the maximum standardized uptake value (SUVmax), which is assessed by pretreatment 18F-fluorodeoxyglucose positron emission tomography with computed tomography, and the overall survival (OS) in patients with hypopharyngeal squamous cell carcinoma from two institutions on long-term follow-up, and examined whether SUVmax is correlated with several survival outcomes, including lung metastasis-free survival. METHODS: A total of 81 patients were enrolled. The survival rate was calculated by the Kaplan-Meier method. Both univariate and multivariate survival analyses were assessed by a Cox proportional hazards model. RESULTS: SUVmax ≥15.2 in institution A (p = 0.0306) or SUVmax ≥8 in institution B (p = 0.0132) was significantly predictor of a lower OS. We disaggregated the data by high SUVmax (SUVmax ≥15.2 from institution A and SUVmax ≥8 from institution B) and low SUVmax (SUVmax <15.2 from institution A and SUVmax <8 from institution B). Patients with a high SUVmax exhibited a significantly lower OS in both univariate (p = 0.001) and multivariate (p = 0.0046) analyses for adjusted for the clinical stage and treatment group. The patients with a high SUVmax exhibited significantly shorter disease-specific (p = 0.0068), distant metastasis-free (p = 0.0428), and lung metastasis-free (p = 0.0328) survivals. CONCLUSIONS: High SUVmax was significantly correlated with a lower OS, disease-specific survival, distant metastasis-free survival, and lung metastasis-free survival in a multi-institutional retrospective study.

    DOI: 10.1007/s12149-017-1176-1

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  342. Portal Vein Bleeding after Pancreatectomy: Diagnosis and Stent Graft Repair - A Consecutive Case Series

    Suzuki Kojiro, Ebata Tomoki, Komada Tomohiro, Matsushima Masaya, Mizuno Takashi, Igami Tsuyoshi, Sugawara Gen, Yokoyama Yukihiro, Naganawa Shinji, Nagino Masato

    JOURNAL OF THE PANCREAS   Vol. 18 ( 4 ) page: 339 - 344   2017.7

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  343. Progression of mean pulmonary arterial pressure in idiopathic pulmonary fibrosis with mild to moderate restriction Reviewed

    Ryo Teramachi, Hiroyuki Taniguchi, Yasuhiro Kondoh, Masahiko Ando, Tomoki Kimura, Kensuke Kataoka, Atsushi Suzuki, Taiki Furukawa, Koji Sakamoto, Yoshinori Hasegawa

    RESPIROLOGY   Vol. 22 ( 5 ) page: 986 - 990   2017.7

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    Background and objectiveElevation of mean pulmonary arterial pressure (MPAP) is associated with poor prognosis in patients with idiopathic pulmonary fibrosis (IPF), yet the progression of MPAP in patients with IPF has not been sufficiently elucidated. We evaluated serial changes in MPAP and its determinants in patients with IPF with mild to moderate restriction.
    MethodsWe retrospectively reviewed patients with IPF who underwent initial evaluations including right heart catheterization (RHC) in our institute from May 2007 to December 2013 with follow-up RHC at least 1year later. Patients with forced vital capacity (FVC)&lt;50% predicted or those with pulmonary artery wedge pressure&gt;15mm Hg were excluded.
    ResultsA total of 95 patients were included. Median follow-up time of second RHC was 1.8years. MPAP increased significantly at follow-up (from 16.8 to 20.2mm Hg; P&lt;0.001), and annual change in MPAP (MPAP) was 1.8mm Hg/year. In multiple regression analysis, the lowest oxygen saturation (SpO(2) ) at 6-min walk test (6MWT) was an independent predictor of MPAP. When adjusted for age, sex, baseline MPAP and FVC % predicted, MPAP was a significant predictor of mortality (hazard ratio: 1.21; P=0.001).
    ConclusionMPAP was significantly associated with desaturation in the 6MWT, and with increased mortality in patients with IPF with mild to moderate restriction.
    We reviewed patients with idiopathic pulmonary fibrosis with mild to moderate restriction and showed that mean pulmonary arterial pressure (MPAP) was progressive. The lowest oxygen saturation (SpO(2) ) in the 6-min walk test at baseline was an independent predictor of annual change in MPAP.

    DOI: 10.1111/resp.12986

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  344. Effect of Gadolinium Deposition on 18F-FDG PET/CT of Dentate Nucleus and Globus Pallidus. Reviewed

    Shinji Naganawa

    J Nucl Med Technol.   Vol. 45 ( 2 ) page: 173   2017.6

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  345. Letter to Editors: Detection of endolymphatic hydrops using traditional MR imaging sequences. Reviewed

    Shinji Naganawa, Michihiko Sone

    Am J Otolaryngol.   ( 17 ) page: 30378-2   2017.6

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  346. FDG PET/CT Overcomes Discordance Between Clinical and Pathologic TNM Classification of Small-size Primary Lung Cancer: Influence on Postoperative Prognosis. Reviewed

    Hiroyasu Umakoshi, Shingo Iwano, Kohei Yokoi, Shinji Ito, Rintaro Ito, Koji Kawaguchi, Takayuki Fukui, Shinji Naganawa

    Clin Lung Cancer.   ( 17 ) page: 30170-5   2017.6

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  347. Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio. Reviewed

    Toshio Ohashi, Shinji Naganawa, Toshio Katagiri, Kayao Kuno

    Magn Reson Med Sci.     2017.6

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    DOI: 10.2463/mrms.mp.2017-0001.

  348. 【MRI最前線】ガドリニウム造影剤と脳脊髄液 glymphaticシステムとは何か?

    田岡 俊昭, 長縄 慎二

    臨床画像   Vol. 33 ( 6 ) page: 652 - 663   2017.6

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    2012年にNedergaardらにより,脳内の老廃物排出系としてのglymphaticシステムが提唱された。この仮説では血管周囲腔と,それを囲むグリアのエンドフィートを介した脳脊髄液による,脳組織の洗い流しによる老廃物の排出を想定している。この仮説と脳内のガドリニウム沈着の関連に関して考察したい。(著者抄録)

    Other Link: https://search.jamas.or.jp/default/link?pub_year=2017&ichushi_jid=J01843&link_issn=&doc_id=20170605150003&doc_link_id=%2Fap4ringc%2F2017%2F003306%2F004%2F0652-0663%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fap4ringc%2F2017%2F003306%2F004%2F0652-0663%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  349. Comparison of accumulation of F-18-FLT PET/CT with histopathological findings of primary and metastatic lesions of urinary tract tumors Reviewed

    Katsuhiko Kato, Shinji Abe, Shinichiro Matsuzawa, Ryuto Mukumoto, Tetsuro Odagawa, Shinji Naganawa

    JOURNAL OF NUCLEAR MEDICINE   Vol. 58   page: .   2017.5

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  350. Clinical outcome of definitive radiation therapy for superficial esophageal cancer. Reviewed

    Yutaro Koide, Takeshi Kodaira, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Makoto Itoh, Tetsuya Abe, Kei Muro, Masahiro Tajika, Yasumasa Niwa, Yoshiyuki Itoh, Shinji Naganawa

    Jpn J Clin Oncol.   Vol. 47 ( 5 ) page: 393-400   2017.5

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  351. Portal Vein Bleeding after Pancreatectomy: Diagnosis and Stent Graft Repair - A Consecutive Case Series. Reviewed

    Kojiro Suzuki, Tomoki Ebata, Tomohiro Komada, Masaya Matsushima, Takashi Mizuno, Tsuyoshi Igami, Gen Sugawara, Yukihiro Yokoyama, Shinji Naganawa, Masato Nagino

    Journal of the Pancreas.   Vol. 18 ( 3 ) page: 241-246   2017.5

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  352. Improved HYDROPS: Imaging of Endolymphatic Hydrops after Intravenous Administration of Gadolinium. Reviewed

    Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Michihiko Sone,

    Magn Reson Med Sci.   Vol. 16 ( 4 ) page: 357-361   2017.5

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  353. Structural MRI correlates of amyotrophic lateral sclerosis progression. Reviewed

    Joe Senda, Naoki Atsuta, Hirohisa Watanabe, Epifanio Bagarinao, Kazunori Imai, Daichi Yokoi, Yuichi Riku, Michihito Masuda, Ryoichi Nakamura, Hazuki Watanabe, Mizuki Ito, Masahisa Katsuno, Shinji Naganawa, Gen Sobue

    J Neurol Neurosurg Psychiatry.   Vol. 88 ( 11 ) page: 901-907   2017.5

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  354. COPD Assessment Test for measurement of health status in patients with idiopathic pulmonary fibrosis: A cross-sectional study Reviewed

    Toshiaki Matsuda, Hiroyuki Taniguchi, Masahiko Ando, Yasuhiro Kondoh, Tomoki Kimura, Kensuke Kataoka, Koji Sakamoto, Atsushi Suzuki, Taiki Furukawa, Yoshinori Hasegawa

    RESPIROLOGY   Vol. 22 ( 4 ) page: 721 - 727   2017.5

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    Background and objectiveThe COPD Assessment Test (CAT) has been reported to have potential utility for measuring health status of idiopathic pulmonary fibrosis (IPF). Although the CAT has been developed for the assessment of COPD patients, it has not been fully evaluated exclusively in IPF. This study was designed to evaluate the validity of the CAT in IPF.
    MethodsThe clinical data for 106 consecutive subjects with newly diagnosed IPF who completed pulmonary function tests, partial pressure of oxygen in arterial blood (PaO2 ) at rest, 6-min walk test (6MWT), CAT, St George's Respiratory Questionnaire (SGRQ), modified Medical Research Council (mMRC) dyspnoea grade and Hospital Anxiety and Depression Scale (HADS), were analysed. We assessed the validity of the CAT in comparison with the SGRQ.
    ResultsThe present subjects showed mild to moderate restrictive impairment on spirometry. Mean CAT score and total SGRQ were 12.88.0 and 30.817.7, respectively. The concurrent validity of the CAT score in comparison with the SGRQ total score was significant (r=0.72, P&lt;0.001). Internal consistency (Cronbach's =0.869) and repeatability over 3months (intraclass correlation coefficient=0.742) of the CAT were also significant. Single regression analysis showed that the CAT had significant construct validity. In multiple regression analysis, mMRC, PaO2 at rest, minimum SpO(2) during 6MWT and anxiety of HADS were independent predictors for the CAT.
    ConclusionsThe CAT is a valid health status measurement in IPF patients. Multiple regression analysis showed that the CAT was significantly correlated with dyspnoea severity, oxygenation impairment and anxiety.
    The validity of the COPD Assessment Test (CAT) was evaluated exclusively in idiopathic pulmonary fibrosis (IPF) patients in comparison with the St George's Respiratory Questionnaire (SGRQ). The CAT had a significant correlation with SGRQ and was independently predicted by dyspnoea severity, oxygenation impairment and anxiety.

    DOI: 10.1111/resp.12936

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  355. Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation

    Go Shinji, Go Shiori, Veillon Lucas, Ciampa Maria Grazia, Mauri Laura, Sato Chihiro, Kitajima Ken, Prinetti Alessandro, Sonnino Sandro, Inokuchi Jin-ichi

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 292 ( 17 ) page: 7040 - 7051   2017.4

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    DOI: 10.1074/jbc.M116.771253

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  356. CSF Pulsation Artifacts on ADC Maps Obtained with Readout-segmented EPI.

    Toshio Ohashi, Shinji Naganawa, Mai Kanou, Mitsuru Ikeda

    Magn Reson Med Sci.   Vol. 16 ( 2 ) page: 123-128   2017.4

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    DOI: 10.2463/mrms.mp.2016-0031

  357. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. Reviewed

    Toshiaki Taoka, Yoshitaka Masutani, Hisashi Kawai, Toshiki Nakane, Kiwamu Matsuoka, Fumihiko Yasuno, Toshifumi Kishimoto, Shinji Naganawa

    Jpn. J Radiol.   ( 35 ) page: 172-178   2017.4

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  358. Lack of Contrast Enhancement in a Giant Perivascular Space of the Basal Ganglion on Delayed FLAIR Images: Implications for the Glymphatic System. Reviewed

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka

    Magn Reson Med Sci.   Vol. 16 ( 2 ) page: 89-90   2017.4

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  359. Magnetic resonance imaging evaluation of endolymphatic hydrops andpost-operative findings in cases with otosclerosis.

    Michihiko Sone, Tadao Yoshida, Satofumi Sugimoto, Kyoko Morimoto, Yuriko Okazaki, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima

    Acta Otolaryngol.   Vol. 137 ( 3 ) page: 242-245   2017.3

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  360. Do gadolinium-based contrast agents affect the 18F-FDG PET/CT uptake in the dentate nucleus and the globus pallidus? Reviewed

    Shinji Naganawa

    J Nucl Med Technol.     2017.3

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    DOI: 10.2967/jnmt.116.187591

  361. Modulation of immunological activity on macrophages induced by diazinon Reviewed

    Nanako Ogasawara, Miyoko Matsushima, Nami Kawamura, Kazuko Atsumi, Takehiro Yamaguchi, Haruka Ochi, Yuto Kusatsugu, Sayaka Oyabu, Naozumi Hashimoto, Yoshinori Hasegawa, Jun Ueyama, Tsutomu Kawabe

    TOXICOLOGY   Vol. 379   page: 22 - 30   2017.3

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    Diazinon is an organophosphorus (OP) insecticide and is widely used not only in agriculture but also homes and garden in Japan. Diazinon has been reported to increase TNF-alpha production in rat serum and brain, suggesting that it can modify the proinflammatory response. In this study, we investigated the effects of diazinon on macrophage functions, such as cytokine production, reactive oxygen species (ROS) generation, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) expressions, cell-surface molecule expressions, and phagocytosis in RAW264.7 cells. In RAW264.7 cells, diazinon induced the production of TNF-alpha and IL-6. Diazinon induced ROS generation and the expressions of COX-2, iNOS, and cell-surface molecules CD40, CD86, and MI-IC class II, but reduced phagocytic activity in RAW264.7 cells. ERIC and p38, but not JNK and p65 were involved in diazinon-induced IL-6 expression in RAW264.7 cells. We also examined these proinflammatory responses in bone marrow-derived macrophages (BMDM) and bronchoalveolar lavage fluid (BALF) cells. These results suggested that diazinon can activate macrophages and enhance inflammatory responses. (C) 2017 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.tox.2017.01.014

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    Other Link: http://orcid.org/0000-0003-0660-2726

  362. Emerging neuroradiological topics in journals from related societies. Reviewed

    Yukunori Korogi, Shinji Naganawa

    Jpn. J Radiol.   Vol. 35 ( 1 ) page: 1-2   2017.2

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  363. Imaging of the endolymphatic space in patients with Ménière's disease. Reviewed

    Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Hironao Otake, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

    Auris Nasus Larynx.   ( 17 ) page: 30142-6   2017.2

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  364. Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer. Reviewed

    Rise Miyauchi, Yoshiyuki Itoh, Mariko Kawamura, Akihiro Hirakawa, Kiyosumi Shibata, Hiroaki Kajiyama, Rie Nakahara, Seiji Kubota, Junji Ito, Tohru Okada, Fumitaka Kikkawa, Shinji Naganawa

    Nagoya J Med Sci.   Vol. 79 ( 2 ) page: 211-220   2017.2

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  365. Dual Energy CTによる小型肺癌の造影評価

    島本 宏矩, 岩野 信吾, 馬越 弘泰, 伊藤 倫太郎, 長縄 慎二

    Japanese Journal of Radiology   Vol. 35 ( Suppl. ) page: 34 - 34   2017.2

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  366. 胸壁並行断面CTを用いた間質性肺炎の定量的評価

    馬越 弘泰, 岩野 信吾, 伊藤 倫太郎, 長縄 慎二

    Japanese Journal of Radiology   Vol. 35 ( Suppl. ) page: 34 - 34   2017.2

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  367. ドパミントランスポータシンチグラフィにおける解析ソフトの有用性に関する研究

    松澤 伸一郎, 加藤 克彦, 国本 啓太, 本田 将之, 椋本 竜斗, 小田川 哲郎, 阿部 真治, 藤田 尚利, 櫻木 庸博, 伊藤 信嗣, 伊藤 倫太郎, 岩野 信吾, 長縄 慎二

    核医学   Vol. 54 ( 1 ) page: 663 - 663   2017.2

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  368. FDG-PETによる非小細胞肺癌の予後予測因子の検討 SUVmaxと体積を考慮した指標の比較

    伊藤 信嗣, 岩野 信吾, 伊藤 倫太郎, 長縄 慎二, 加藤 克彦

    核医学   Vol. 54 ( 1 ) page: 565 - 565   2017.2

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  369. Structure of the Medullary Veins of the Cerebral Hemisphere and Related Disorders. Reviewed

    Toshiaki Taoka, Akio Fukuisumi, Toshiteru Miyasaka, Hisashi Kawai, Toshiki Nakane, Kimihiko Kichikawa, Shinji Naganawa

    Radiographics.   Vol. 37 ( 1 ) page: 281-297   2017.1

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  370. Endolymphatic hydrops in patients with unilateral and bilateral Meniere's disease.

    Kyoko Morimoto, Tadao Yoshida, Saiko Sugiura, Masahiro Kato, Ken Kato, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

    Acta Otolaryngol.   Vol. 137 ( 1 ) page: 23-28   2017.1

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  371. Visualization of Middle Ear Ossicles in Elder Subjects with Ultra-short Echo Time MR Imaging

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Kojiro Suzuki, Shingo Iwano, Hiroko Satake, David Grodzki

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 16 ( 2 ) page: 93 - 97   2017

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    Purpose: To evaluate the visualization of middle ear ossicles by ultra-short echo time magnetic resonance (MR) imaging at 3T in subjects over 50 years old.
    Materials and Methods: Sixty ears from 30 elder patients that underwent surgical or interventional treatment for neurovascular diseases were included (ages: 50-82, median age: 65; 10 men, 20 women). Patients received follow-up MR imaging including routine T1-and T2-weighted images, time-of-flight MR angiography, and ultra-short echo time imaging (PETRA, pointwise encoding time reduction with radial acquisition). All patients underwent computed tomography (CT) angiography before treatment. Thin-section source CT images were correlated with PETRA images. Scan parameters for PETRA were: TR 3.13, TE 0.07, flip angle 6 degrees, 0.83 x 0.83 x 0.83 mm resolution, 3 min 43 s scan time. Two radiologists retrospectively evaluated the visibility of each ossicular structure as positive or negative using PETRA images. The structures evaluated included the head of the malleus, manubrium of the malleus, body of the incus, long process of the incus, and the stapes. Signal intensity of the ossicles was classified as: between labyrinthine fluid and air, similar to labyrinthine fluid, between labyrinthine fluid and cerebellar parenchyma, or higher than cerebellar parenchyma.
    Results: In all ears, the body of the incus was visible. The head of the malleus was visualized in 36/60 ears. The manubrium of the malleus and long process of the incus was visualized in 1/60 and 4/60 ears, respectively. The stapes were not visualized in any ear. Signal intensity of the visible structures was between labyrinthine fluid and air in all ears.
    Conclusion: The body of the incus was consistently visualized with intensity between air and labyrinthine fluid on PETRA images in aged subjects. Poor visualization of the manubrium of the malleus, long process of the incus, and the stapes limits clinical significance of middle ear imaging with current PETRA methods.

    DOI: 10.2463/mrms.mp.2015-0171

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  372. Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 16 ( 1 ) page: 61 - 65   2017

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    Purpose: In textbooks, the perivascular space (PVS) is described as non-enhancing after the intravenous administration of gadolinium-based contrast agent (IV-GBCA). We noticed that the PVS sometimes has high signal intensity (SI) on heavily T-2-weighted 3D-FLAIR (hT(2)-FL) images obtained 4 h after IV-GBCA. The purpose of this study was to retrospectively evaluate the contrast enhancement of the PVS.
    Materials and Methods: In 8 healthy subjects and 19 patients with suspected endolymphatic hydrops, magnetic resonance cisternography (MRC) and hT(2)-FL images were obtained before and 4 h after a single dose of IV-GBCA. No subjects had renal insufficiency. On axial MRC at the level of the anterior commissure (AC)-posterior commissure (PC) line, 1 cm circular regions of interest (ROIs) were drawn centering on the PVS in the bilateral basal ganglia and thalami. Three-millimeter diameter ROIs were set in the cerebrospinal fluid (CSF) of the bilateral ambient cistern. The ROIs on MRC were copied onto the hT2-FL images and the SI was measured. The SI ratio (SIR) was defined as SIRPVS = SI of PVS/SI of the thalami, and SIRCSF = SI of CSF/SI of the thalami. The average of the bilateral values was used for the calculation. The SIRCSF, SIRPVS, and SI of the thalami were compared between before and 4 h after IV-GBCA.
    Results: The SIR was increased significantly from 1.02 +/- 0.37 to 2.65 +/- 0.82 in the CSF (P &lt; 0.01) and from 1.20 +/- 0.35 to 2.13 +/- 1.23 in the PVS at 4 h after IV-GBCA (P &lt; 0.01). The SI of the thalami showed no significant difference.
    Conclusion: The enhancement of the PVS at 4 h after IV-GBCA was confirmed even in subjects without renal insufficiency. It is possible that the GBCA in the blood vessels might have permeated into the cerebrospinal fluid (CSF) space and the PVS. This might be a first step in the imaging evaluation of the glymphatic system (waste clearance system) of the brain.

    DOI: 10.2463/mrms.mp.2016-0039

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  373. Detection of endolymphatic hydrops using traditional MR imaging sequences

    Naganawa Shinji, Sone Michihiko

    AMERICAN JOURNAL OF OTOLARYNGOLOGY   Vol. 38 ( 5 ) page: 637-638   2017

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  374. Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall: A pilot study. Reviewed International journal

    Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    PloS one   Vol. 12 ( 9 ) page: e0185532   2017

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    OBJECTIVES: To quantify the imaging findings of patients with interstitial pneumonia (IP) and emphysema using three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall, and compare the results to visual assessment of IP and each patient's diffusing capacity of the lungs for carbon monoxide (DLco). METHODS: We retrospectively reviewed the axial CT findings and pulmonary function test results of 95 patients with lung cancer (72 men and 23 women, aged 45-84 years) with or without IP, as follows: non-IP (n = 47), mild IP (n = 31), and moderate IP (n = 17). The 3D-cHRCT images of the lung at a 1-cm depth from the chest wall were reconstructed automatically using original software; total area (TA), high-attenuation area (HAA) >-500 HU, and low-attenuation area (LAA) <-950 HU were calculated on a workstation. The %HAA and %LAA were calculated as follows: [Formula: see text], and [Formula: see text]. RESULTS: The %HAA and %LAA respective values were 3.2±0.9 and 27.7±8.2, 3.9±1.2 and 27.6±5.9, and 6.9±2.2 and 25.4±8.7 in non-IP, mild IP, and moderate IP patients, respectively. There were significant differences in %HAA between the 3 groups of patients (P<0.001), but no differences in %LAA (P = 0.558). Multiple linear regression analysis revealed that %HAA and %LAA were negatively correlated with predicted DLco (standard partial regression coefficient [b*] = -0.453, P<0.001; b* = -0.447, P<0.001, respectively). CONCLUSIONS: The %HAA and %LAA values computed using 3D-cHRCT were significantly correlated with DLco and may be important quantitative parameters for both IP and emphysema.

    DOI: 10.1371/journal.pone.0185532

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  375. CSF Pulsation Artifacts on ADC Maps Obtained with Readout-segmented EPI

    Ohashi Toshio, Naganawa Shinji, Kanou Mai, Ikeda Mitsuru

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 16 ( 2 ) page: 123-128   2017

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    DOI: 10.2463/mrms.mp.2016-0031

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  376. A multicenter survey of stage T1 glottic cancer treated with radiotherapy delivered in 2.25-Gy fractions in clinical practice: An initial 5-year analysis.

    Yoshiyuki Itoh, Seiji Kubota, Mariko Kawamura, Yoshihito Nomoto, Takayuki Murao, Kouji Yamakawa, Shunichi Ishihara, Naoki Hirasawa, Akiko Asano, Shigeo Yanagawa, Shinji Naganawa

    Nagoya J. Med. Sci.   Vol. 78 ( 4 ) page: 399-406   2016.12

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  377. Active brain changes after initiating fingolimod therapy in multiple sclerosis patients using individual voxel-based analyses for diffusion tensor imaging. Reviewed

    Joe Senda, Hirohisa Watanabe, Kuniyuki Endo, Keizo Yasui, Yasuhiro Hawsegawa, Noritaka Yoneyama, Takashi Tsuboi, Kazuhiro Hara, Mizuki Ito, Naoki Atsuta, Bagarinao Epifanio Jr, Masahisa Katsuno, Shinji Naganawa, Gen Sobue

    Nagoya J Med Sci.   Vol. 78 ( 4 ) page: 455-463   2016.12

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  378. Magnetic resonance imaging of cardiac sarcoidosis: an evaluation of the cardiac segments and layers that exhibit late gadolinium enhancement. Reviewed

    Tomohiro Komada, Kojiro Suzuki, Hiroaki Ishiguchi, Hisashi Kawai, Takahiro Okumura, Akihiro Hirashiki, Shinji Naganawa

    Nagoya J. Med. Sci.   Vol. 78   page: 437-446   2016.11

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  379. Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum.

    Michihito Masuda, Joe Senda, Hirohisa Watanabe, Bagarinao Epifanio, Yasuhiro Tanaka, Kazunori Imai, Yuchi Riku, Yuanzhe Li, Ryoichi Nakamura, Mizuki Ito, Shinsuke Ishigaki, Naoki Atsuta, Haruki Koike, Katsuno Masahisa, Nobutaka Hattori, Shinji Naganawa, Gen Sobue

    Amyotroph Lateral Scler Frontotemporal Degener.   Vol. 17 ( 7-8 ) page: 571-579   2016.10

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  380. Ⅳ ISMRMから読み解くMRI最新動向 1.臨床の視点から見たISMRM2016のトピックス―頭頸部領域を中心に

    長縄慎二

    INNERVISION   Vol. 31 ( 9 ) page: 66-68   2016.9

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  381. Impact of Thin-Section Computed Tomography-Determined Combined Pulmonary Fibrosis and Emphysema on Outcomes Among Patients With Resected Lung Cancer Reviewed

    Naozumi Hashimoto, Shingo Iwano, Koji Kawaguchi, Takayuki Fukui, Koichi Fukumoto, Shota Nakamura, Shunsuke Mori,Koji Sakamoto, Kenji Wakai, Kohei Yokoi, Yoshinori Hasegawa

    Ann Thorac Surg.   Vol. 102 ( 2 ) page: 440-447   2016.8

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  382. BOOK REVIEW:頭頸部の臨床画像診断学 改訂第3版

    長縄慎二

    画像診断   Vol. 36 ( 8 ) page: 799   2016.7

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  383. Diffusion tensor studies and voxel-based morphometry of the temporal lobe to determine the cognitive prognosis in cases of Alzheimer's disease and mild cognitive impairment: Do white matter changes precede gray matter changes?

    Toshiaki Taoka, Fumihiko Yasuno, Masayuki Morikawa, Makoto Inoue, Kuniaki Kiuchi, Soichiro Kitamura, Kiwamu Matsuoka, Toshifumi Kishimoto, Kimihiko Kichikawa, Shinji Naganawa

    SpringerPlus.   Vol. 5 ( 1 ) page: 1023   2016.7

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  384. Evaluation of locoregional invasiveness of small-sized non-small cell lung cancers by enhanced dual-energy computed tomography. Reviewed

    Hironori Shimamoto, Shingo Iwano, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Naganawa

    Cancer Imaging.   Vol. 16 ( 1 ) page: 18   2016.7

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  385. Characterization of stochastic noise and post-irradiation density growth for reflective-type radiochromic film in therapeutic photon beam dosimetry. Reviewed

    Takeshi Kamomae, Masataka Oita, Naoki Hayashi, Motoharu Sasaki, Hideki Aoyama, Hiroshi Oguchi, Mariko Kawamura, Hajime Monzen, Yoshiyuki Itoh, Shiniji Naganawa

    Phys Med   Vol. 32   page: 1314-1320   2016.7

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  386. Late Rectal Toxicity from Image-guided Intensity Modulated Radiotherapy for Prostate Cancer.

    Maki S, Itoh Y, Kubota S, Okada T, Nakahara R, Ito J, Kawamura M, Kamomae T, Naganawa S, Yoshino Y, Gotoh M, Ikeda M

    Anticancer Res.   Vol. 36 ( 6 ) page: 2967-2973   2016.6

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  387. Meniere's disease.

    Tsutomu Nakashima, Ilmari Pyykko, Megan A. Arroll, Margaretha L. Casselbrant, Carol A. Foster, Nauman F. Manzoor, Cliff A. Megerian, Shinji Naganawa, Yi Ho Young

    Nat Rev Dis Primers.     2016.5

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    DOI: 10.1038/nrdp.2016.28.

  388. Contrast-enhanced magnetic resonance pancreatography with gadoteridol by heavily T2-weighted three-dimensional fluid-attenuated inversion recovery: preliminary results in healthy subjects.

    Kojiro Suzuki, Shinji Naganawa, Naohiro Furuhashi, Masahiro Yamazaki, Hiroshi Ogawa and Hisashi Kawai

    Nagoya J. Med. Sci.   Vol. 78 ( 2 ) page: 175-181   2016.5

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  389. Application of histogram analysis for the evaluation of vascular permeability in glioma by the K2 parameter obtained with the dynamic susceptibility contrast method: Comparisons with Ktrans obtained with the dynamic contrast enhance method and cerebral blood volume.

    Toshiaki Taoka, Hisashi Kawai , Toshiki Nakane , Saeka Hori, Tomoko Ochi, Toshiteru Miyasaka, Masahiko Sakamoto, Kimihiko Kichikawa, Shinji Naganawa

    Magn Reson Imaging.   Vol. 34 ( 7 ) page: 896-901   2016.4

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  390. Comparison of the multidetector-row computed tomography findings of IgG4-related sclerosing cholangitis and extrahepatic cholangiocarcinoma.

    Yata Masaki, Suzuki Kojiro, Furuhashi Naohiro, Kawakami K, Kawai Y, Naganawa Shinji

    Clin Radiol.   Vol. 71 ( 3 ) page: 203-210   2016.3

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  391. Time Course of Diffusion Kurtosis in Cerebral Infarctions of Transient Middle Cerebral Artery Occlusion Rat Model.

    Toshiaki Taoka, Masayuki Fujioka, Yuto Kashiwagi, Atsushi Obata, Takemi Rokugawa, Masaaki Hori, Yoshitaka Masutani, Shigeki Aoki, Shinji Naganawa, Kohji Abe

    J Stroke Cerebrovasc Dis.   Vol. 25 ( 3 ) page: 610-617   2016.3

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  392. 非正規分布拡散画像の評価方法の開発

    田岡俊昭、長縄慎二、川井 恒

    脳とこころの研究センター 脳疾患克服に向けた次世代創訳開発のためのコホート・コンソーシアム型研究拠点形成 平成27年度活動報告書     page: 32   2016.3

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  393. Simple Estimation of the Endolymphatic Volume Ratio after Intravenous Administration of a Single-dose of Gadolinium Contrast.

    Shinji Naganawa, Mai Kanou, Toshio Ohashi, Kayao Kuno, Michihiko Sone

    Magn Reson Med Sci.     2016.3

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    DOI: 10.2463/mrms.mp.2015-0175

  394. Cochlear Lymph Fluid Signal Increase in Patients with Otosclerosis after Intravenous Administration of Gadodiamide.

    Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Kojiro Suzuki, Shingo Iwano, Hiroko Satake, Michihiko Sone, Mitsuru Ikeda

    Magn Reson Med.     2016.2

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    DOI: 10.2463/mrms.mp.2015-0121

  395. 夢について

    長縄慎二

    健康文化   Vol. 50   page: 77-79   2015.12

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  396. White Matter Abnormality Correlates with Developmental and Seizure Outcomes in West Syndrome of Unknown Etiology.

    Jun Natsume, Chikako Ogawa, Tatsuya Fukasawa, Hiroyuki Yamamoto, Naoko Ishihara, Yoko Sakaguchi, Yuji Ito, Tomoya Takeuchi, Yoshiki Azuma, Naoki Ando, Tetsuo Kubota, Takeshi Tuji, Hisashi Kawai, Shinji Naganawa, Hiroyuki Kidokoro

    AJNR Am J Neuroradiol.     2015.11

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    DOI: 10.3174/ajnr.A4589.

  397. Heavily T2-Weighted 3D-FLAIR Improves the Detection of Cochlear Lymph Fluid Signal Abnormalities in Patients with Sudden Sensorineural Hearing Loss.

    Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Kojiro Suzuki, Shingo Iwano, Hiroko Satake, Michihiko Sone, Mitsuru Ikeda

    Magn Reson Med Sci.     2015.11

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    DOI: 10.2463/mrms.mp.2015-0065

  398. Endolymphatic hydrops in superior canal dehiscence and large vestibular aqueduct syndromes.

    Michihiko Sone, Tadao Yoshida, Kyoko Morimoto , Masaaki Teranishi, Tsutomu Nakashima, Shinji Naganawa

    Laryngoscope.     2015.11

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    DOI: 10.1002/lary.25747.

  399. Changes in endolymphatic hydrops in patients with Ménière's disease treated conservatively for more than 1 year.

    Suga K, Kato M, Yoshida T, Nishio N, Nakada T, Sugiura S, Otake H, Kato K, Teranishi M, Sone M, Naganawa S, Nakashima T.

    Acta Otolaryngol.   Vol. 135 ( 9 ) page: 866-870   2015.9

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  400. Ⅷ ISMRMから読み解くMRI最新動向 1.臨床の視点から見たISMRM2015のトピックス 1)頭頸部領域

    長縄慎二

    INNERVISION   Vol. 30 ( 9 ) page: 63-65   2015.9

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  401. CASE OF THE MONTH―THE KEY TO Case of August―(8月号掲載のCASE OF THE MONTHの解答)

    岩野信吾、長縄慎二

    画像診断   Vol. 35 ( 12 ) page: 1442-1444   2015.9

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  402. How the Non-attending Brain Hears Its Owner's Name.

    Toshiki Nakane, Makoto Miyakoshi, Toshiharu Nakai, Shinji Naganawa

    Cereb Cortex.     page: in press   2015.9

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    DOI: 10.1093/cercor/bhv184

  403. Correlation between FDG-PET/CT findings and solid type non-small cell cancer prognostic factors: are there differences between adenocarcinoma and squamous cell carcinoma?

    Rintaro Ito, Shingo Iwano, Mariko Kishimoto, Shinji Ito, Katsuhiko Kato, Shinji Naganawa

    Ann Nucl Med.     page: in press   2015.9

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    DOI: 10.1007/s12149-015-1025-z

  404. Evaluation of lung cancer by enhanced dual-energy CT: association between three-dimensional iodine concentration and tumour differentiation.

    Shingo Iwano, Rintaro Ito, Hiroyasu Umakoshi, Shinji Ito, Shinji Naganawa

    Br J Radiol.     page: in press   2015.9

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    DOI: 10.1259/bjr.20150224

  405. A Randomized, Double-Blind Pilot Trial of Hydrolyzed Rice Bran versus Placebo for Radioprotective Effect on Acute Gastroenteritis Secondary to Chemoradiotherapy in Patients with Cervical Cancer.

    Yoshiyuki Itoh, Mika Mizuno, Mitsuru Ikeda, Rie Nakahara, Seiji Kubota, Junji Ito, Tohru Okada, Mariko Kawamura, Fumitaka Kikkawa, Shinji Naganawa

    Evidence-Based Complementary and Alternative Medicine.     page: in press   2015.9

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    DOI: Article ID:974390

  406. Ossicular Anomaly and Endolymphatic Hydrops as Risk Factors for Complications after Ossiculoplasty. Reviewed

    Norihiko Inagaki, Tadao Yoshida, Michihiko Sone, Satofumi Sugimoto, Hironao Otake, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima

    Austin J Radiol   Vol. 2 ( 5 ) page: 1029   2015.8

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  407. CASE OF THE MONTH―THE KEY TO Case of July―(7月号掲載のCASE OF THE MONTHの解答)

    佐竹弘子、石垣聡子、長縄慎二

    画像診断   Vol. 35 ( 10 ) page: 1316-1318   2015.8

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  408. CASE OF THE MONTH―CASE OF September―

    鈴木耕次郎、小川 浩、長縄慎二

    画像診断   Vol. 35 ( 10 ) page: 1315   2015.8

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  409. 2.解剖・正常変異―部位別の鑑別診断―Q2.読影に必要な脳神経の解剖について簡単に教えてください。   

    長縄慎二

    画像診断   Vol. 35 ( 10 ) page: 1211-1213   2015.8

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  410. Prediction of background parenchymal enhancement on breast MRI using mammography, ultrasonography, and diffusion-weighted imaging.

    Akiko Kawamura, Hiroko Satake, Satoko Ishigaki, Mitsuru Ikeda, Reiko Kimura, Kazuhiro Shimamoto and Shinji Naganawa

    Nagoya J Med Sci   Vol. 77 ( 3 ) page: 425-437   2015.8

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  411. Background parenchymal enhancement in preoperative breast MRI.

    Satoko Kohara, Satoko Ishigaki, Hiroko Satake, Akiko Kawamura, Hisashi Kawai, Toyone Kikumori and Shinji Naganawa

    Nagoya J Med Sci   Vol. 77 ( 3 ) page: 373-382   2015.8

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  412. Pancreatic neuroendocrine tumors containing areas of iso- or hypoattenuation in dynamic contrast-enhanced computed tomography: Spectrum of imaging findings and pathological grading. Reviewed

    Ryota Hyodo, Kojiro Suzuki, Hiroshi Ogawa, Tomohiro Komada, Shinji Naganawa

    Eur J Radiol.     2015.8

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    DOI: 10.1016/j.ejrad.2015.08.014.

  413. A phase I/II trial of intraoperative breast radiotherapy in an Asian population: 5-year results of local control and cosmetic outcome.

    Kawamura M, Itoh Y, Sawaki M, Kikumori T, Tsunoda N, Kamomae T, Kubota S, Okada T, Nakahara R, Ito J, Hayashi H, Naganawa S.

    Radiat Oncol.   Vol. 10 ( 150 )   2015.7

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    DOI: 10.1186/s13014-015-0469-6.

  414. CASE OF THE MONTH―CASE OF August―

    岩野信吾、長縄慎二

    画像診断   Vol. 35 ( 9 ) page: 1147   2015.7

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  415. Stent-graft treatment for extrahepatic portal vein hemorrhage after pancreaticoduodenectomy.

    Suzuki K, Igami T, Komada T, Mori Y, Yokoyama Y, Ebata T, Naganawa S, Nagino M.

    Acta Radiol Open.   Vol. 4 ( 6 ) page: 1-4   2015.6

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  416. CASE OF THE MONTH―CASE OF July―

    佐竹弘子、石垣聡子、長縄慎二

    画像診断   Vol. 35 ( 8 ) page: 1007   2015.6

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  417. Differentiation of focal-type autoimmune pancreatitis from pancreatic carcinoma: assessment by multiphase contrast-enhanced CT. Reviewed

    Naohiro Furuhashi, Kojiro Suzuki, Yusuke Sakurai, Mitsuru Ikeda, Yuichi Kawai, Shinji Naganawa

    Eur Radiol   Vol. 25 ( 5 ) page: 1366-1374   2015.5

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  418. 今後MRI診断はいかなる領域を拓いていくべきか

    長縄慎二

    新医療   Vol. 486 ( 6 ) page: 28-31   2015.5

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  419. Cerumen impaction shown by brain magnetic resonance imaging in patients with cognitive impairment. Reviewed

    Tsutomu Nakashima, Saiko Sugiura, Shinji Naganawa, Minori Yasue, Yoshitaka Inui, Takeshi Sakurai, Yasue Uchida, Michihiko Sone, Masaaki Teranishi, Tadao Yoshida, Kengo Ito, Kenji Toba

    Geriatr Gerontol Int.     2015.5

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    DOI: 10.1111/ggi.12529.

  420. 乳がんにおける画像診断の最新トピックス

    石垣聡子、佐竹弘子、川井 恒、長縄慎二

    東海核医学セミナー症例集:2-5     page: 2-5   2015.5

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  421. Critical evaluation of a prospective study of concurrent chemoradiotherapy with s-1 for early glottic carcinoma. Reviewed

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Rie Nakahara, Mariko Kawamura, Seiji Kubota, Junji Itoh, Mariko Hiramatsu, Yasushi Fujimoto, Takashi Shibata, Shinji Naganawa

    ANTICANCER RESEARCH.   Vol. 35 ( 4 ) page: 2385-2390   2015.4

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  422. 胆道癌の最新の画像診断 MDCT,EOM-MRI,PET(Recent advances in diagnostic imaging of biliary carcinoma: MDCT,EOB-MRI and PET)

    鈴木耕次郎、古橋尚博、小川 浩、長縄慎二

    消化器外科   Vol. 38 ( 5 ) page: 765-771   2015.4

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  423. 胆管癌と胆管炎

    鈴木耕次郎、古橋尚博、小川 浩、長縄慎二

    画像診断   Vol. 35 ( 6 ) page: 699-711   2015.4

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  424. アイソトープと核医学

    長縄慎二

    名古屋大学アイソトープ総合センターTRACER   Vol. 57   page: 1-2   2015.3

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  425. 放射線科活動年次報告

    川井 恒、長縄慎二

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 平成26年度活動報告書     page: 34   2015.3

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  426. Ratio of Vestibular Endolymph in Patients with Isolated Lateral Semicircular Canal Dysplasia. Reviewed

    Shinji Naganawa, Hisashi Kawai, Michihiko Sone, Mitsuru Ikeda

    Magn Reson Med Sci.     2015.3

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    DOI: 10.2463/mrms.2014-0112

  427. Volume Quantification of Endolymph after Intravenous Administration of a Single Dose of Gadolinium Contrast Agent: Comparison of 18- versus 8-minute Imaging Protocols. Reviewed

    Shinji Naganawa, Toshio Ohashi, Mai Kanou, Kayao Kuno, Michihiko Sone, Mitsuru Ikeda

    Magn Reson Med Sci.     2015.3

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    DOI: 10.2463/mrms.2014-0118

  428. The Technical and Clinical Features of 3D-FLAIR in Neuroimaging. Reviewed

    Shinji Naganawa

    Magn Reson Med Sci.   Vol. 14 ( 2 ) page: 93-106   2015.3

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    DOI: 10.2463/mrms.2014-0132

  429. 内耳の造影MRIによる内リンパ水腫画像                           -その撮像と評価について、いま放射線科医が知っておくべきこと- Reviewed

    長縄慎二

    画像診断    Vol. 35 ( 2 ) page: 278-289   2015.2

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  430. Patient with an SLC26A4 gene mutation who had low-frequency sensorineural hearing loss and endolymphatic hydrops Reviewed

    Tadao Yoshida, Michihiko Sone, Shinji Naganawa, Tsutomu Nakashima

    The Journal of Laryngology & Otology     page: 1-3   2015

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  431. 健康づくり

    長縄慎二

    健康文化   Vol. 49   page: 1   2014.12

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  432. 乳がんとマンモグラフィ

    長縄慎二

    名大病院 かわらばん     page: 4   2014.10

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  433. 私を変えたこの論文【14】

    長縄慎二

    臨床画像   Vol. 30 ( 10 ) page: 1158-1161   2014.10

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  434. 日常診療にすぐに役立つCT/MRIの基礎と活用法-中枢神経系疾患- 序論

    長縄慎二

    日獨医報   Vol. 59 ( 2 ) page: 4   2014.10

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  435. Ability of 18-fludeoxyglucose positron emission tomography/CT to detect incidental cancer. Reviewed

    Y Sone, A Sobajima, T Kawachi, S Kohara, K Kato, Shinji Naganawa

    Br J Radiol. (87) 1042   Vol. 87 ( 1042 )   2014.10

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    DOI: 10.1259/bjr.20140030.

  436. 臨床の立場から見たISMRM2014のトピックス

    長縄慎二

    INNERVISION   Vol. 29 ( 9 ) page: 67-69   2014.9

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  437. Quiet Suite 臨床編(2) qPETRA/qRESOLVEの使用経験と有用性

    川井 恒、長縄慎二

    INNERVISION   Vol. 29 ( 9 ) page: 46-47   2014.9

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  438. 3D Real Inversion Recovery MR Imaging for the Visualization of Endolymphatic Hydrops. Reviewed

    Shinji Naganawa, M Sone

    AJNR Am J Neuroradiol.     2014.9

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    DOI: 10.3174/ajnr.A4126

  439. VISUALIZATION OF BRAIN WHITE MATTER TRACTS USING HEAVILY T2-WEIGHTED THREE-DIMENSIONAL FLUID-ATTENUATED INVERSION-RECOVERY MAGNETIC RESONANCE IMAGING Reviewed

    Masahiro Yamazaki, Shinji Naganawa, Kiminori Bokura, Hisashi Kawai

    Nagoya J. Med. Sci. 76 No.3,4 285-291   Vol. 76 ( 3,4 ) page: 285-291   2014.8

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  440. Endolymphatic space size in patients with vestibular migraine and Ménière's disease.

    Nakada T, Yoshida T, Suga K, Kato M, Otake H, Kato K, Teranishi M, Sone M, Sugiura S, Kuno K, Pyykkö I, Naganawa S, Watanabe H, Sobue G, Nakashima T

    J Neurol.     2014.8

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    DOI: 10.1007/s00415-014-7458-9

  441. Evaluation of 11C-choline PET/CT for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract: a pilot study. Reviewed

    Naoto Sassa, Katsuhiko Kato, Shinji Abe, Shingo Iwano, Shinji Ito, Mitsuru Ikeda, Kazuhiro Shimamoto, Seiichi Yamamoto, Tokunori Yamamoto, Momokazu Gotoh, Shinji Naganawa

    Eur J Nucl Med Mol Imaging     2014.8

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    DOI: 10.1007/s00259-014-2871-y

  442. 腫瘍性病変との鑑別が困難であった小児骨髄炎の1例

    伊藤倫太郎、中根俊樹、長縄慎二、濱 麻人、筑紫 聡、下山芳江

    映像情報Medical   Vol. 46 ( 6 ) page: 518-519   2014.6

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  443. 内耳―3D-FLAIR法がもたらした新たな潮流

    長縄慎二

    INNERVISION 5月号     page: 49-51   2014.4

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  444. Visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: Does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?

    Masahiro Yamazaki, Shinji Naganawa, Hisashi Kawai, Mitsuru Ikeda, Kiminori Bokura, Haruo Isoda, Tsutomu Nakashima

    PLoS ONE   Vol. 9 ( 3 )   2014.3

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    DOI: 10.1371/journal.pone.0091860

  445. Retrospective Case Series of 15 Patients Treated with Chemoradiation Using 5-FU and Nedaplatin for Gynecological Malignancy: With Regard to Hemotoxicity.

    Yoshiyuki Itoh, Mitsuru Ikeda, Naoki Hirasawa, Shunichi Ishihara, Takahito Okuda, Takayuki Murao, Seiji Kubota, Tohru Okada, Shinji Naganawa, Takeo Ishigaki

    Nagoya Journal of Medical Science.   Vol. 76   page: 11-16   2014.2

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  446. FDG-PET/CTで陰性所見を示した肺腫瘤性病変の検討

    岩野信吾、長縄慎二、伊藤信嗣、加藤克彦

    臨床放射線   Vol. 59 ( 1 ) page: 154-164   2014.1

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  447. MRI and FDG-PET for Assessment of Response to Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer

    Toshisada Aiba, Keisuke Uehara, Takashi Nihashi, Toyonori Tsuzuki, Hiroshi Yatsuya, Yuichiro Yoshioka

    Ann Surg Oncol.   Vol. 21   page: 1801-1808   2014.1

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  448. A phase I study of concurrent chemoradiotherapy using oral s-1 for head and neck cancer.

    Yasushi fujimoto, Satoshi Kato, Yoshiyuki Itoh, Shinji Naganawa, Tsutomu Nakashima

    ANTICANCER RESEARCH   Vol. 34   page: 209-214   2014

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  449. Potential of a new MRI for visualizing cerebellar involvement in progressive supranuclear palsy.

    Kazuhiro Hara, Hirohisa Watanabe, Mizuki Ito, Takashi Tsuboi, Hazuki Watanabe, Ryoichi Nakamura, Jo Senda, Naoki Atsuta, Hiroaki Adachi, Ikuko Aiba, Shinji Naganawa, Gen Sobue

    Parkinsonism Relat Disord.   Vol. 20 ( 2 ) page: 157-161   2014

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  450. Clinical and radiological impact of liver transplantation for brain in cirrhosis patients without hepatic encephalopathy.

    Ishihara Tetsuro, Ito Mizuki, Niimi Yoshiki, Tsujimoto Masashi, Senda Jo, Kawai Yoshinari, Watanabe Hirohisa, Ishigami Masatoshi, Ito Takashi, Kamei Hideya, Onishi Yasuharu, Nakamura Taro, Goto Hidemi, Naganawa Shinji, Kiuchi Tetsuya, Sobue Gen.

    Clin Neurol Neurosurg. 2013 Nov;115(11):2341-7.   Vol. 115 ( 11 ) page: 2341-7   2013.11

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  451. 難聴を合併したMPO―ANCA 関連血管炎患者の3D―FLAIR MR 画像評価

    加藤 健、曾根三千彦、寺西正明、吉田忠雄、大竹宏直、中島 務、長縄慎二

    日本耳鼻咽喉科学会会誌   Vol. 116   page: 1192-1199   2013.11

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  452. Cortical and subcortical brain atrophy in Parkinson's disease with visual hallucination.

    Watanabe Hirohisa, Senda Jo, Kato Shigenori, Ito Mizuki, Atsuta Naoki, Hara Kazuhiro, Tsuboi Takashi, Katsuno Masahisa, Nakamura Tomohiko, Hirayama Masaaki, Adachi Hiroaki, Naganawa Shinji, Sobue Gen.

    Mov Disord.   Vol. 28 ( 12 ) page: 1732-6   2013.10

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  453. Endolymphatic hydrops revealed by magnetic resonance imaging in patients with acute low-tone sensorineural hearing loss.

    Shimono M, Teranishi M, Yoshida T, Kato M, Sano R, Otake H, Kato K, Sone M, Ohmiya N, Naganawa S, Nakashima T

    Otol Neurotol   Vol. 34 ( 7 ) page: 1241-6   2013.7

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  454. MRI進化への視点を示す 〈狭い、うるさい、長時間かかる〉果たしてMRIは優しくなれるか メーカーへの提言をふくめて

    長縄慎二

    新医療   Vol. 462 ( 6 ) page: 24-26   2013.6

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  455. Limited Efficacy of 18F-FDG PET/CT for Differentiation Between Metastasis-Free Pancreatic Cancer and Mass-Forming Pancreatitis.

    Kato K, Nihashi T, Ikeda M, Abe S, Iwano S, Itoh S, Shimamoto K, Naganawa S.

    Clin Nucl Med.   Vol. 38 ( 6 ) page: 417-21   2013.6

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  456. Comparison of Liquid Crystal Display Monitors Calibrated With Gray-Scale Standard Display Function and With γ 2.2 and iPad: Observer Performance in Detection of Cerebral Infarction on Brain CT.

    Yoshimura K, Nihashi T, Ikeda M, Ando Y, Kawai H, Kawakami K, Kimura R, Okada Y, Okochi Y, Ota N, Tsuchiya K, Naganawa S.

    AJR Am J Roentgenol.   Vol. 200 ( 6 ) page: 1304-1309.   2013.6

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  457. Three-dimensional Visualization of Endolymphatic Hydrops after Intravenous Administration of Single-dose Gadodiamide.

    Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T.

    Magn Reson Med Sci.     page: in press   2013.5

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  458. Magnetic resonance imaging of the inner ear after both intratympanic and intravenous gadolinium injections.

    Iida T, Teranishi M, Yoshida T, Otake H, Sone M, Kato M, Shimono M, Yamazaki M, Naganawa S, Nakashima T

    Acta Otolaryngol   Vol. 133 ( 5 ) page: 434-8   2013.5

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  459. Relationship of Myocardial Fibrosis to Left Ventricular and Mitochondrial Function in Nonischemic Dilated Cardiomyopathy-A Comparison of Focal and Interstitial Fibrosis.

    Yamada T, Hirashiki A, Cheng XW, Okumura T, Shimazu S, Okamoto R, Shinoda N, Isobe S, Takeshita K, Naganawa S, Kondo T, Murohara T

    J Card Fail   Vol. 19 ( 8 ) page: 557-64   2013.5

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  460. Visualization of Endolymphatic Hydrops in Ménière's Disease after Intravenous Administration of Single-dose Gadodiamide at 1.5T.

    Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T.

    Magn Reson Med Sci.     page: in press   2013.5

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  461. 18F-FDG-PET/CT predicts survival in hypopharyngeal squamous cell carcinoma.

    Suzuki H, Kato K, Fujimoto Y, Itoh Y, Hiramatsu M, Maruo T, Naganawa S, Hasegawa Y, Nakashima T.

    Ann Nucl Med.   Vol. 27 ( 3 ) page: 297-302   2013.4

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  462. Comparison of the central adrenal vein and the common trunk of the left adrenal vein for adrenal venous sampling. Reviewed

    Takada A, Suzuki K, Mori Y, Hyodo R, Kawakami K, Okochi Y, Naganawa S.

    J Vasc Interv Radiol.   Vol. 24 ( 4 ) page: 550 - 557   2013.4

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  463. Imaging of Ménière's disease after intravenous administration of single-dose gadodiamide: utility of multiplication of MR cisternography and HYDROPS image.

    NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu

    Magn Reson Med Sci   Vol. 12 ( 1 ) page: 63-68   2013.3

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  464. Pulmonary lobar volumetry using novel volumetric computer-aided diagnosis and computed tomography.

    Iwano S, Kitano M, Matsuo K, Kawakami K, Koike W, Kishimoto M, Inoue T, Li Y, Naganawa S.

    Interact Cardiovasc Thorac Surg.     page: in press   2013.3

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  465. Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere's disease.

    KATO Masahiro, SUGIURA Makoto, SHIMONO Mariko, YOSHIDA Tadao, OTAKE Hironao, KATO Ken, TERANISHI Masaaki, SONE Michihiko, YAMAZAKI Masahiro, NAGANAWA Shinji, NAKASHIMA Tsutomu

    Acta Otolaryngol   Vol. 133 ( 2 ) page: 123-129   2013.2

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  466. Planning of segmentectomy using three-dimensional computed tomography angiography with a virtual safety margin: Technique and initial experience.

    Iwano S, Yokoi K, Taniguchi T, Kawaguchi K, Fukui T, Naganawa S

    Lung Cance   Vol. 81 ( 3 ) page: 410-415   2013

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  467. Pulmonary lobar volumetry using novel volumetric computer-aided diagnosis and computed tomography.

    Iwano S, Kitano M, Matsuo K, Kawakami K, Koike W, Kishimoto M, Inoue T, Li Y, Naganawa S

    Interact Cardiovasc Thorac Surg     page: in press   2013

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  468. 乳癌―広がり診断―

    佐竹弘子、石垣聡子、長縄慎二

    画像診断 33(9)   Vol. 33 ( 9 ) page: 1044-1051   2013

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  469. second look US―切除範囲決定の実際―

    佐竹弘子、石垣聡子、長縄慎二

    臨床画像   Vol. 29 ( 11 ) page: 1292-1300   2013

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  470. Clinical Evaluation of 12 Patients with Cervical Lymph Node Metastases from Squamous Cell Carcinoma of Unknown Primary: a Retrospective Review

    Nishiyama Kana, Itoh Yoshiyuki, Nakahara Rie, Asano Akiko, Okada Tohru, Kubota Seiji, Maki Sayo, Itoh Junji, Fujimoto Yasushi, Nakashima Tsutomu, Naganawa Shinji

    Austral-Asian Journal of Cancer   Vol. 12 ( 4 ) page: 275-283   2013

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  471. Doubling time calculations for lung cancer by three-dimensional computer-aided volumetry: Effects of inter-observer differences and nodule characteristics.

    Koike Wataru, Iwano Shingo, Matsuo Keiji, Kitano Mariko, Kawakami Kenichi, Naganawa Shinji

    J Med Imaging Radiat Oncol.     page: DOI   2013

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    DOI: DOI

  472. (18)F-FDG-PET/CT predicts survival in hypopharyngeal squamous cell carcinoma.

    Hidenori Suzuki, Katsuhiko Kato, Yasushi Fujimoto, Yoshiyuki Itoh, Mariko Hiramatsu, Takashi Maruo, Shinji Naganawa, Yasuhisa Hasegawa, Tsutomu Nakashima

    Ann Nucl Med.   Vol. 27 ( 3 ) page: 297-302   2013

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  473. Evaluation of vascular activity in otosclerosis by laser Doppler flowmetry: comparison with computed tomographic densitometry.

    Sone Michihiko, Yoshida Tadao, Otake Hironao, Kato Ken, Teranishi Masaaki, Naganawa Shinji, Nakashima Tsutomu.

    Otol Neurotol.   Vol. 34 ( 9 ) page: 1559-63   2013

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  474. Cutting-edge MRI techniques for studying neurological diseases focusing on spinocerebellar degeneration.

      Vol. 53 ( 11 ) page: 1087-90   2013

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  475. Clinical use of 11C-methionine and 18F-FDG-PET for germinoma in central nervous system.

    Yoshiyuki Okochi, Takashi Nihashi, Masazumi Fuji, Katsuhiko Kato, Yumiko Okada, Yoshio Ando, Satoshi Maesawa, Shigenori Takebayashi, Toshihiko Wakabayashi, Shinji Naganawa

    Ann Nucl Med.   Vol. 24   page: DOI   2013

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  476. 神経疾患におけるMR撮像法の最先端:脊髄小脳変性症を中心に

    渡辺 宏久、千田 譲、伊藤 瑞規、熱田 直樹、原 一洋、渡辺 はづき、中村 亮一、坪井 崇、吉田 眞理、長縄 慎二、祖父江 元

    臨床神経学 2013;53(11):1087-90   Vol. 53 ( 11 ) page: 1087-90   2013

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  477. Establishing Normal Diameter Range of the Cochlear and Facial Nerves with 3D-CISS at 3T.

    Rei Nakamichi, Masahiro Yamazaki, Mitsuru Ikeda, Haruo Isoda, Hisashi Kawai, Michihiko Sone, Tsutomu Nakashima, Shinji Naganawa

    Magn Reson Med Sci.   Vol. 12 ( 4 ) page: 241-247   2013

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  478. Semi-quantification of Endolymphatic Size on MR Imaging after Intravenous Injection of Single-dose Gadodiamide: Comparison between Two Types of Processing Strategies.

    Shinji Naganawa, Kojiro Suzuki, Rei Nakamichi, Kiminori Bokura, Tadao Yoshida, Michihiko Sone, Homann Georg, Tsutomu Nakashima, Mitsuru Ikeda

    Magn Reson Med Sci.   Vol. 12 ( 4 ) page: 261-269   2013

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  479. Imaging of Ménière's disease by subtraction of MR cisternography from positive perilymph image.

    NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu

    Magn Reson Med Sci   Vol. 11 ( 4 ) page: 303-309   2012.12

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  480. Gadolinium distribution in cochlear perilymph: differences between intratympanic and intravenous gadolinium injection.

    Yamazaki M, Naganawa S, Kawai H, Sone M, Nakashima T

    Neuroradiology   Vol. 54 ( 10 ) page: 1161-9   2012.10

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  481. Differentiation of newly diagnosed glioblastoma multiforme and intracranial diffuse large B-cell Lymphoma using 11C-methionine and 18F-FDG PET.

    Okada Y, Nihashi T, Fujii M, Kato K, Okochi Y, Ando Y, Yamashita M, Maesawa S, Takebayashi S, Wakabayashi T, Naganawa S

    Clin Nucl Med   Vol. 37 ( 9 ) page: 843-9   2012.9

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  482. Imaging of Ménière's disease after intravenous administration of single-dose gadodiamide: utility of subtraction images with different inversion time.

    NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu

    Magn Reson Med Sci   Vol. 11 ( 3 ) page: 213-219   2012.9

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  483. 臨床の立場から見たISMRM2012のトピックス

    長縄慎二

    INNERVISION   Vol. 27 ( 9 ) page: 71-72   2012.9

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  484. Peak width in multifrequency tympanometry and endolymphatic hydrops revealed by magnetic resonance imaging.

    Kato K, Yoshida T, Teranishi M, Sano R, Otake H, Sone M, Naganawa S, Nakashima T

    Otol Neurotol   Vol. 33 ( 6 ) page: 912-5   2012.8

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  485. Gadolinium distribution in cochlear perilymph: differences between intratympanic and intravenous gadolinium injection.

    YAMAZAKI Masahiro, NAGANAWA Shinji, KAWAI Hisashi, SONE Michihiko, NAKASHIMA Tsutomu

    Neuroradiology   Vol. 54 ( 10 ) page: 1161-1169   2012.8

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  486. MRI mean diffusivity detects widespread brain degeneration in multiple sclerosis

    SENDA JOE ,WATANABE HIROHISA,TSUBOI TAKASHI ,HARA KAZUHIRO,WATANABE HAZUKI ,NAKAMURA RYOICHI,ITO MIZUKI,ATSUTA NAOKI,TANAKA FUMIAKI,NAGANAWA SHINJI,SOBUE GEN

    Journal of the Neurological Sciences   Vol. 319 ( 1-2 ) page: 105-10   2012.8

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  487. Correlation between dynamic CT findings and pathological prognostic factors of small lung adenocarcinoma.

    IWANO SHINGO, KOIKE WATARU, MATSUO KEIJI, KITANO MARIKO, KAWAKAMI KENICHI, OKADA TOHRU, NAGANAWA SHINJI

    Cancer Imaging.   Vol. 29 ( 12 ) page: 187-93   2012.6

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  488. MRIを施設のアイコンにするための要件と課題を説く

    長縄慎二

    新医療   ( 6 ) page: 28-30   2012.6

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  489. Virtual Bronchoscopic Navigation(VBN)による気管支鏡下生検経路の診断精度

    岸本真理子、岩野信吾、長縄慎二

    映像情報メディカル   Vol. 44 ( 6 ) page: 602-603   2012.6

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  490. 3D-CT Lung Volumetry Using Multidetector Row Computed Tomography:Pulmonary Function of Each Anatomic Lobe. Reviewed

    IWANO SHINGO, OKADA TOHRU, SATAKE HIROKO, NAGANAWA SHINJI

    J Thorac Imaging   Vol. 27 ( 3 ) page: 164 - 170   2012.5

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  491. Contrast enhancement of the inner ear in magnetic resonance images taken at 10 minutes or 4 hours after intravenous gadolinium injection.

    Sano R, Teranishi M, Yamazaki M, Isoda H, Naganawa S, Sone M, Hiramatsu M, Yoshida T, Suzuki H, Nakashima T

    Acta Otolaryngol   Vol. 132 ( 3 ) page: 241-246   2012.5

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  492. 急性感音難聴の新しい画像診断

    長縄慎二

    JOHNS   Vol. 28 ( 5 ) page: 747-750   2012.5

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  493. Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection.

    YAMAZAKI MASAHIRO, NAGANAWA SHINJI, TAGAYA MITSUHIKO, KAWAI HISASHI, IKEDA MITSURU, SONE MICHIHIKO, TERANISHI MASAAKI, SUZUKI HIROKAZU, NAKASHIMA TSUTOMU

    AJNR Am J Neuroradiol   Vol. 33 ( 4 ) page: 773–78   2012.4

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  494. CT findings of intraductal papillary neoplasm of the bile duct: Assessment with multiphase contrast-enhanced examination using multi-detector CT.

    OGAWA HIROSHI,ITOH SHIGEKI,NAGASAKA TETSURO,SUZUKI KOJIRO,OTA TOYOHIRO,NAGANAWA SHINJI

    Clin Radiol   Vol. 67 ( 3 ) page: 224-231   2012.3

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  495. Audiological signs in pediatric cases with dehiscence of the bony labyrinth caused by a high jugular bulb.

    Michihiko Sone, Naomi Katayama, Shinji Naganawa, Tadao Yoshida, Masaaki Teranishi,Tsutomu Nakashima

    Int J Pediatr Otorhinolaryngol   Vol. 76 ( 3 ) page: 447-451   2012.3

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  496. Diffusion-weighted imaging of breast masses: comparison of diagnostic performance using various apparent diffusion coefficient parameters.

    HIRANO MAKI,SATAKE HIROKO,ISHIGAKI SATOKO,IKEDA MITSURU,KAWAI HISASHI,NAGANAWA SHINJI

    AJR Am J Roentgenol   Vol. 198 ( 3 ) page: 717-22   2012.3

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  497. 十二指腸乳頭部癌の画像診断-マルチスライスCTを中心に-

    高田章、鈴木耕次郎、石垣聡子、伊藤茂樹、長縄慎二

    胆と膵   Vol. 33 ( 3 ) page: 243-248   2012.3

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  498. Estimation of I-123 IMP arterial blood activity using I-123 IMP acquisition data from the lungs and brain without any blood sampling: Validation of its usefulness for quantification of regional cerebral blood flow.

    ABE SHINJI, KATO KATSUHIKO, TAKAHASHI YOSHITAKE, FUJITA NAOTOSHI, YAMASHITA MASATO, SHINODA MASAKI, IKEDA MITSURU, OTA NAOTOSHI, KAJITA YASUKAZU, NAGANAWA SHINJI

    Clin Nucl Med   Vol. 37 ( 3 ) page: 258-263   2012.3

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  499. Imaging of Ménière's Disease after Intravenous Administration of Single-dose Gadodiamide: Utility of Subtraction Images with Different Inversion Time.

    Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T.

    Magn Reson Med Sci   Vol. 11 ( 3 ) page: 213-9   2012.3

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  500. Imaging of endolymphatic and perilymphatic fluid after intravenous administration of single-dose gadodiamide.

    Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T

    Magn Reson Med Sci   Vol. 11 ( 2 ) page: 145-50   2012.2

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  501. 脳機能MR画像解析-3T MR装置における施設内及び施設間の再現性の検証-

    長縄慎二

    映像情報メディカル   Vol. 44 ( 1 ) page: 104-105   2012.1

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  502. 画像検査

    長縄慎二、中島 務

      Vol. 30 ( 1 ) page: 61-63   2012.1

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  503. Comparison of computed tomography and magnetic resonance imaging for evaluation of cholesteatoma with labyrinthine fistulae.

    Michihiko Sone, Tadao Yoshida, Shinji Naganawa, Hironao Otake, Ken Kato, Rui Sano, Masaaki Teranishi,Tsutomu Nakashima

        page: 10.1002   2012

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  504. Study of the Cost-Benefit Analysis of Electronic Medical Record Systems in General Hospital in China.

    Li K, Naganawa S, Wang K, Li P, Kato K, Li X, Zhang J, Yamauchi K.

    J Med Syst     page: 10.1007   2012

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  505. Estimation of perilymph enhancement after intrarympanic administration of Gd-DTPA by fast T1-mapping with dual flip angle 3D-spoiled gradient echo sequence Reviewed

    NAGANAWA SHINJI, MASAHIRO YAMAZAKI, KAWAI HISASHI, NAKASHIMA TSUTOMU

    Proc.Intl.Mag.Reson.Med     page: .   2012

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  506. MRI mean diffusivity detects widespread brain degeneration in multiple sclerosis

    SENDA JOE ,WATANABE HIROHISA,TSUBOI TAKASHI ,HARA KAZUHIRO,WATANABE HAZUKI ,NAKAMURA RYOICHI,ITO MIZUKI,ATSUTA NAOKI,TANAKA FUMIAKI,NAGANAWA SHINJI,SOBUE GEN

    Journal of the Neurological Sciences     page: .   2012

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  507. Autoimmune pancreatitis: Assessment of the enhanced duct sign on multiphase contrast-enhanced computed tomography

    KAWAI YUICHI,SUZUKI KOJIRO,ITOH SHIGEKI,TAKADA AKIRA,MORI YOSHINE,NAGANAWA SHINJI

    European Journal of Radiology     page: .   2012

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  508. The diagnosis of neurodegenerative disorders based on clinical and pathological findings using an MRI approach.

    Rinsho Shinkeigaku   Vol. 51 ( 11 ) page: 863-864   2011.11

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  509. Contrast Enhancement of the Anterior Eye Segment and Subarachnoid Space: Detection in the Normal State by Heavily T(2)-weighted 3D FLAIR.

    NAGANAWA SHINJI,YAMAZAKI MASAHIRO,KAWAI HISASHI,SONE MICHIHIKO,NAKASHIMA TSUTOMU

    Magn Reson Med Sci   Vol. 10 ( 3 ) page: 193-199   2011.10

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  510. Foreign body granulomaと病理診断された腫瘤形成性膵炎の1例

    河合雄一、鈴木耕次郎、小川浩、太田豊裕、長縄慎二、伊藤茂樹、藤井努

    臨床放射線   Vol. 56 ( 10 ) page: 1250-1253   2011.10

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  511. Anatomical Details of the Brainstem and Cranial Nerves Visualized by High Resolution Readout-segmented Multi-shot Echo-planar Diffusion-weighted Images using Unidirectional MPG at 3T.

    Naganawa S, Yamazaki M, Kawai H, Sone M, Nakashima T, Isoda H

    Magn Reson Med Sci   Vol. 10 ( 4 ) page: 269-275   2011.10

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  512. 側頭骨 (内耳、内耳道)

    長縄慎二

    画像診断 臨時増刊号   Vol. 31 ( 11 ) page: S108-S118   2011.9

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  513. 臨床の立場から見たISMRM2011のトピックス-イメージングバイオマーカーとしての進歩・定量化を中心に

    長縄慎二

    INNERVISION   Vol. 26 ( 9 ) page: 57-59   2011.9

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  514. 乳腺造影3T MRIの診断法と臨床的意義

    佐竹弘子、石垣聡子、木村麗子、川井 恒、長縄慎二

    INNERVISON   Vol. 26 ( 9 ) page: 82-86   2011.9

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  515. Scattered radiation from dental metallic crowns in head and neck radiotherapy.

    Shimozato T, Igarashi Y, Itoh Y, Yamamoto N, Okudaira K, Tabushi K, Obata Y, Komori M, Naganawa S, Ueda M.

    Phys Med Biol.   Vol. 56 ( 17 ) page: 5525-5534   2011.8

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  516. Images of a Case of Carney Triad by Combined F-18 FDG PET/CT.

    KATO KATSUHIKO, KOIKE WATARU, IWANO SHINGO, USAMI NORIHIRO, YOKOI KOHEI, UEDA YUICHI, NAGANAWA SHINJI

    Clin Nucl Med   Vol. 36 ( 8 ) page: 698-700   2011.8

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  517. CTを利用した子宮頸癌腔内照射の治療システムの構築 画像誘導小線源治療に向けて

    平澤直樹、伊藤善之、久保田誠司、青山裕一、野口由美子、奥平訓康、中原理絵、牧 紗代、石原俊一、三宅良和、長縄慎二

    臨床放射線   Vol. 56 ( 7 ) page: 873-877   2011.7

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  518. 普及型と研究型に棲み分けされるMRIの今後を示す

    長縄慎二

    新医療   Vol. 438 ( 6 ) page: 24-27   2011.6

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  519. Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging

    TSUJIMOTO MASASHI,SENDA JO , ISHIHARA TETSURO, NIIMI YOSHIKI, KAWAI YOSHINARI, ATSUTA NAOKI,WATANABE HIROHISA, TANAKA FUMIAKI, NAGANAWA SHINJI, SOBUE GEN

    J Neurol Sci.   Vol. 307 ( 1-2 ) page: 34-40   2011.6

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  520. 乳癌に対する乳房部分切除後の放射線治療 術中照射を中心に

    石原俊一、伊藤善之、中原理絵、牧 紗代、久保田誠司、平澤直樹、長縄慎二、今井常夫、菊森豊根、澤木正孝、青山裕一、三宅良和

    臨床放射線   Vol. 56 ( 4 ) page: 501-510   2011.4

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  521. Accuracy of 3.0 Tesla magnetic resonance imaging in the diagnosis of intracochlear schwannoma.

    YOSHIDA TADAO ,SONE MICHIHIKO,NAGANAWA SHINJI,NAKASHIMA TSUTOMU

    Auris Nasus Larynx   Vol. 38 ( 4 ) page: 551-554   2011.4

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  522. A comparative contrast perception phantom image of brain CT study between high-grade and low-grade liquid crystal displays (LCDs) in electronic medical charts

    YOSHIMURA KUMIKO, SHIMAMOTO KAZUHIRO , IKEDA MITSURU , ICHIKAWA KATSUHIRO , NAGANAWA SHINJIPhysica Medica

    Physica Medica   ( 27 ) page: 109-116   2011.4

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  523. Contrast-enhanced MRI of the inner ear after intratympanic injection of meglumine gadopentetate or gadodiamide hydrate.

    SUZUKI HIROKAZU,TERANISHI MASAAKI,NAGANAWA SHINJI,NAKATA SEIICHI,SONE MICHIHIKO,NAKASHIMA TSUTOMU

    Acta Otolaryngol   Vol. 131 ( 2 ) page: 130-135   2011.2

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  524. Visualization of Endolymphatic Hydrops after Intratympanic Injection of Gd-DTPA: Comparison of 2D and 3D Real Inversion Recovery Imaging.

    NAGANAWA SHINJI,SONE MICHIHIKO ,YAMAZAKI MASAHIRO,KAWAI HISASHI,NAKASHIMA TSUTOMU

    Magn Reson Med Sci.   Vol. 10 ( 2 ) page: 101-106   2011.2

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  525. Endolympathic hydrops in patients with vestibular schwannoma: visualization by non-contrast-enhanced 3D FLAIR.

    Naganawa S, Kawai H, Sone M, Nakashima T, Ikeda M

    Neuroradiology     2011.1

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    DOI: in press

  526. Predictive value for malignancy of suspicious breast masses of BI-RADS categories 4 and 5 using ultrasound elastography and MR diffusion-weighted imaging.

    SATAKE HIROKO,NISHIO AKIKO,IKEDA MITSURU, ISHIGAKI SATOKO, SHIMAMOTO KAZUHIRO, HIRANO MAKI, NAGANAWA SHINJI

    AJR Am J Roentgenol   Vol. 196 ( 1 ) page: 202-209   2011.1

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  527. Progressive and widespread brain damage in ALS: MRI voxel-based morphometry and diffusion tensor imaging study.

    Senda J, Kato S, Kaga T, Ito M, Atsuta N, Nakamura T, Watanabe H, Tanaka F, Naganawa S, Sobue G

    Amyotroph Lateral Scler   Vol. 12 ( 1 ) page: 59-56   2011.1

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  528. 特発性と考えられた陳旧性肝内血腫の1例

    鈴木耕次郎、森芳峰、長縄慎二、太田豊裕、伊藤茂樹、野本周嗣

    臨床放射線   Vol. 56   page: 1098-1102   2011

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  529. Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection.

    YAMAZAKI MASAHIRO, NAGANAWA SHINJI, TAGAYA MITSUHIKO, KAWAI HISASHI, IKEDA MITSURU, SONE MICHIHIKO, TERANISHI MASAAKI, SUZUKI HIROKAZU, NAKASHIMA TSUTOMU

    AJNR Am J Neuroradiol     page: .   2011

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  530. Segmentectomy Simulation using a Virtual Three-dimensional Safety Margin.

    IWANO SHINGO, USAMI NORIYASU, YOKOI KOHEI, NAGANAWA SHINJI

    Ann Thorac Surg     page: in press   2011

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  531. EARLY PREDICTION OF RESPONSE TO NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED BREAST CANCER USING MRI.

    KAWAMURA MARIKO, SATAKE HIROKO, ISHIGAKI SATOKO, NISHIO AKIKO, SAWAKI MASATAKA , NAGANAWA SHINJI

    Nagoya J Med Sci   Vol. 73 ( 3-4 ) page: 147-156   2011

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  532. Contrast enhancement of the inner ear after intravenous administration of a standard or double dose of gadolinium contrast agents.

    SUZUKI HIROKAZU, TERANISHI MASAAKI, SONE MICHIHIKO, YAMAZAKI MASAHIRO, NAGANAWA SHINJI, NAKASHIMATSUTOMU

    Acta Oto-Laryngologica   Vol. 131   page: 1025-1031   2011

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  533. FDG-PET performed concurrently with initial I-131 ablation for differentiated thyroid cancer.

    Iwano Shingo, Kato Katsuhiko, Ito Shinji, Tsuchiya Kenichi, Naganawa Shinji

    Ann Nucl Med     page: in press   2011

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  534. Association Between Endolymphatic Hydrops as Revealed by Magnetic Resonance Imaging and Caloric Response.

    KATO MASAHIRO, TERANISHI MASAAKI, KATAYAMA NAOMI, SONE MICHIHIKO, NAGANAWA SHINJI, NAKASHIMA TSUTOMU

    Otology & Neurotology   Vol. 32 ( 9 ) page: 1480-1485   2011

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  535. ここまでわかる耳鼻咽喉科MRI「内耳のMRI」

    中島務、長縄慎二

    MB ENT   Vol. 122   page: 20-26   2010.12

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  536. Magnetic resonance imaging of the inner ear in Meniere's disease.

    Ilmari Pyykk&ouml;; Jing Zou; Dennis Poe; Tsutomu Nakashima; Shinji Naganawa

    Otolaryngologic clinics of North America   Vol. 43 ( 5 ) page: 1059-1080   2010.10

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  537. パーキンソニズムを呈する疾患のMRI診断

    渡辺宏久、吉田眞理、饗場郁子、長縄慎二、祖父江元

    自律神経   Vol. 47 ( 5 ) page: 402-411   2010.10

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  538. 臨床の立場からみたISMRMへのトピックスー7Tを中心とした国際的な動向について

    長縄慎二

      Vol. 25 ( 9 ) page: 62-62   2010.9

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  539. Increased sensitivity to low concentration gadolinium contrast by optimized heavily T2-weighted 3D-FLAIR to visualize endolymphatic space.

    NAGANAWA SHINJI, KAWAI HISASHI, SONE MICHIHIKO,NAKASHIMA TSUTOMU

    Magn Reson Med Sci   Vol. 9   page: 73-80   2010.9

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  540. Simultaneous three-dimensional visualization of the intra-parotid facial nerve and parotid duct using a three-dimensional reversed FISP sequence with diffusion weighting.

    NAGANAWA SHINJI, ISHIHARA SHUNICHI, SATAKE HIROKO, KAWAI HISASHI, SONE MICHIHIKO, NAKASHIMA TSUTOMU

    Magn Reson Med Sci   Vol. 9   page: 153-158   2010.9

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  541. CT findings in autoimmune pancreatitis: assessment using multiphase contrast-enhanced multisection CT.

    SUZUKI KOJIRO, ITOH SHIGEKI, NAGASAKA T, OGAWA HIROSHI, OTA TOYOHIRO, NAGANAWA SHINJI

    Clin Radiol   Vol. 65   page: 735-743   2010.9

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  542. Diagnostic value of SPIO-mediated breath-hold, black-blood, fluid-attenuated, inversion recovery (BH-BB-FLAIR) imaging in patients with hepatocellular carcinomas.

    MATSUSHIMA MASAYA, NAGANAWA SHINJI, IKEDA MITSURU, ITOH SHIGEKI, OGAWA HIROSHI, KOMADA TOMOHIRO, ISHIGAKI SATOKO, KAWAI HISASHI, SUZUKI KOJIRO, SATAKE HIROKO, IWANO SHINGO

    Magn Reason Med Sci   Vol. 9 ( 2 ) page: 49-58   2010.9

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  543. Evaluation of 11C-choline PET/CT for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract: a pilot study.

    Naoto Sassa, Katsuhiko Kato, Shinji Abe, Shingo Iwano, Shinji Ito, Mitsuru Ikeda, Kazuhiro Shimamoto, Seiichi Yamamoto, Tokunori Yamamoto, Momokazu Gotoh, Shinji Naganawa

    Eur J Nucl Med Mol Imaging     2010.8

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    DOI: 10.1007/s00259-014-2871-y

  544. 臨床に及ぼす画像診断機器の有用性と今後の展望

    医療機器システム白書   Vol. 2010~2011   page: 16-20   2010.7

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  545. Imaging findings in a case with cholesteatoma in complete aural atresia.

    Sone M, Naganawa S, Yoshida T, Nakata S, Nakashima T

    Am J Otolaryngol   Vol. 31 ( 4 ) page: 297-299   2010.7

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  546. 側頭骨領域の造影3T MRI

    長縄慎二

    INNERVISION   Vol. 25 ( 7 ) page: 6-10   2010.7

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  547. なぜ先進的病院が高磁場MRIを導入・稼動しなければならないのか

    長縄慎二

    新医療   Vol. 6   page: 28-31   2010.6

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  548. Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis.

    HIRASAWA NAOKI, ITOH YOSHIYUKI ISHIHARA SHUNICHI, KUBOTA SEIJI, ITOH JUNJI, FUJIMOTO YASUSHI, NAKASHIMA TSUTOMU, NAGANAWA SHINJI

    Head Neck Oncol   Vol. 2 ( 20 )   2010.6

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  549. 早期声門癌に対する治療方針に関するアンケート調査 耳鼻科医を対象とした調査結果

    平澤直樹、伊藤善之、石原俊一、長縄慎二、鈴木一徳、野本由人、村尾豪之、堀川よしみ、小山一之、笹岡政宏、浅野晶子、小幡康範

    臨床放射線   Vol. 55   page: 541-546   2010.5

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  550. White matter microstructure of the cingulum and cerebellar peduncle is related to sustained attention and working memory: A diffusion tensor imaging study.

    Takahashi M, Iwamoto K, Fukatsu H, Naganawa S, Iidaka T, Ozaki N

    Neurosci Lett   Vol. 477 ( 2 ) page: 72-76   2010.4

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  551. 第3回論文発表における学術研究成果報告のノウハウ

    長縄慎二

    映像情報Medical   Vol. 42 ( 3 ) page: 316-317   2010.3

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  552. Three-dimensional (3D) visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: optimization of a 3D-real inversion-recovery turbo spin-echo (TSE) sequence and application of a 32-channel head coil at 3T.

    Shinji Naganawa, Shunichi Ishihara,Shingo Iwano,Michihiko Sone, Tsutomu Nakashima

    JOURNAL OF MAGNETIC RESONANCE IMAGING   Vol. 31   page: 210-241   2010.1

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  553. Relationship between endolymphatic hydrops and vestibular-evoked myogenic potential.

    Katayama Naomi, Yamamoto Masako, Teranishi Masaaki, Naganawa Shinji, Nakata Seiichi, Sone Michihiko, Nakashima Tsutomu

    Acta Otolaryngol   Vol. 130 ( 8 ) page: 917-923   2010.1

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  554. Detection of presumed hemorrhage in the ampullar endolymph of the semicircular canal: a case report.

    Naganawa, Shinji; Ishihara, Shunichi; Iwano, Shingo; Sone, Michihiko; Nakashima, Tsutomu

    Magn Reson Med Sci   Vol. 8   page: 187-191   2010

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    We examined a 61-year-old woman with sudden left-side hearing loss accompanied by severe vertigo. High signal in the ampullar endolymph of the left semicircular canal on magnetic resonance (MR) fluid attenuated inversion recovery (3D-FLAIR) images suggested labyrinthine hemorrhage. The patient had been treated for chronic heart failure and prescribed 100 mg/day of acetylsalicylic acid (aspirin) for its antiplatelet effect. The 3D-FLAIR images demonstrated a small amount of focal hemorrhage in the labyrinthine fluid that may have been overlooked on T(1)-weighted images.

  555. MR imaging of the Cochlear Modiolus after Intratympanic Administration of Gd-DTPA

    Hisashi Kawai, Shinji Naganawa, Shunichi Ishihara, Michihiko Sone, Tsutomu Nakashima

    Magn Reson Med Sci   Vol. 9 ( 1 ) page: 23-29   2010

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  556. Estimation of Gadolinium-induced T(1)-shortening with Measurement of Simple Signal Intensity Ratio between the Cochlea and Brain Parenchyma on 3D-FLAIR: Correlation with T(1) Measurement by TI Scout Sequence.

    Shinji Naganawa, Shunichi Ishihara,Shingo Iwano,Hisashi Kawai, Michihiko Sone, Tsutomu Nakashima

    Magn Reson Med Sci   Vol. 9 ( 1 ) page: 17-22   2010

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  557. 3 Tesla magnetic resonance imaging obtained 4 hours after intravenous gadolinium injection in patients with sudden deafness.

    Tagaya, Mitsuhiko; Teranishi, Masaaki; Naganawa, Shinji; Iwata, Tomoyuki; Yoshida, Tadao; Otake, Hironao; Nakata, Seiichi; Sone, Michihiko; Nakashima, Tsutomu

    Acta Otolaryngol   Vol. 130   page: 665-669   2010

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  558. Signal Alteration of the Cochlear Perilymph on 3 Different Sequences after Intratympanic Gd-DTPA Administration at 3 Tesla:Comparison of 3D-FLAIR,3D-T1-weighted Imaging,and 3D-CISS.

    Yamazaki Masahiro,Naganawa Shinji,Kawai Hisashi,Nihashi Takashi,Nakashima Tsutomu

    Magn Reason Med Sci   Vol. 9 ( 2 ) page: 65-71   2010

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  559. Correlation between estimated glomerular filtration rate (eGFR) and apparent diffusion coefficient (ADC) values of the kidneys.

    Toya Reiko,Naganawa Shinji,Kawai Hisashi,Ikeda Mitsuru

    Magn Reson Med Sci   Vol. 9   page: 59-64   2010

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  560. A comparative contrast perception phantom image of brain CT study between high-grade and low-grade liquid crystal displays (LCDs) in electronic medical charts.

    Yoshimura Kumiko, Shimamoto Kazuhiro, Ikeda Mitsuru, Ichikawa Katsuhiro, Naganawa Shinji

    Phys Med.   Vol. in press   2010

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  561. Putaminal magnetic resonance imaging features at various magnetic field strengths in multiple system atrophy.

    Watanabe H, Ito M, Fukatsu H, Senda J, Atsuta N, Kaga T, Kato S, Katsuno M, Tanaka F, Hirayama M, Naganawa S, Sobue G

    Mov Disord   Vol. in press   2010

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  562. Impact of adjustment measures on reducing outpatient waiting time in a community hospital: application of a computer simulation.

    Chen, Bai-lian; Li, En-dong; Yamawuchi, Kazunobu; Kato, Ken; Naganawa, Shinji; Miao, Wei-jun

    Chin Med J (Engl)   Vol. 123 ( 5 ) page: 574-580   2010

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  563. Relationship between the Degree of Endolymphatic Hydrops and Electrocochleography.

    Yamamoto M, Teranishi M, Naganawa S, Otake H, Sugiura M, Yamamoto Masako, Teranishi Masaaki, Naganawa Shinji, Otake Hironao, Sugiura Makoto, Iwata Tomoyuki, Yoshida Tadao, Katayama Naomi, Nakata Seiichi, Sone Michihiko, Nakashima Tsutomu

    Audiol Neurootol   Vol. 15   page: 254-260   2010

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  564. Virtual bronchoscopy-guided transbronchial biopsy for aiding the diagnosis of peripheral lung cancer.

    Iwano Shingo, Imaizumi Kazuyozhi, Okada Tohru, Hasegawa Yoshinori, Naganawa Shinji

    Eur J Radiol   Vol. in press   2010

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    The aim of this study was to evaluate the clinical value of virtual bronchoscopy (VB) in aiding diagnosis of peripheral lung cancer by transbronchial biopsy (TBB). In addition, we sought to systematically analyze the factors that affect the diagnostic sensitivity of VB-guided TBB for the evaluation of peripheral lung cancers. MATERIALS AND METHODS: A hundred and twenty-two peripheral lung cancers from 122 patients (82 men and 40 women, 38-84 years; median 68.5 years) who were performed VB-guided TBB were evaluated retrospectively. VB was reconstructed from 1- or 0.5-mm slice thickness images of multi-detector CT (MDCT). Experienced pulmonologists inserted the conventional and ultrathin bronchoscopes into the target bronchus under direct vision following the VB image. RESULTS: A definitive diagnosis was established by VB-guided TBB in 96 lesions (79%). The diagnostic sensitivity of small pulmonary lesions </=30mm in maximal diameter (71%) was significantly lower than that of lesions >30mm (91%, p=0.008). For small pulmonary lesions </=30mm (n=76), internal opacity of the lesion was the independent predictor of diagnostic sensitivity by VB-guided TBB, and the non-solid type lung cancers were significantly lower than the solid type and part-solid type lung cancers for diagnostic sensitivity (odds ratio=0.161; 95% confidence interval=0.033-0.780; p=0.023). CONCLUSION: Use of an ultrathin bronchoscope and simulation with VB reconstructed by high quality MDCT images is thought to improve pathological diagnosis of peripheral lung cancers, especially for solid and partly solid types. For small pulmonary lesions </=30mm, the lesion internal opacity is a significant factor for predicting the diagnostic sensitivity, and the sensitivity was low for small non-solid type of lung cancers.

  565. Correlation between pyramidal tract degeneration and widespread white matter involvement in amyotrophic lateral sclerosis: a study with tractography and diffusion-tensor imaging.

    Senda, Joe; Ito, Mizuki; Watanabe, Hirohisa; Atsuta, Naoki; Kawai, Yoshinari; Katsuno, Masahisa; Tanaka, Fumiaki; Naganawa, Shinji; Fukatsu, Hiroshi; Sobue, Gen

    Amyotroph Lateral Scler   Vol. 10   page: 288-294   2009.12

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    Our aim was to evaluate the location and extent of white matter involvement in patients with amyotrophic lateral sclerosis (ALS) using diffusion-tensor magnetic resonance imaging (DTI). We obtained fractional anisotropy (FA) values from the internal capsule and various white matter regions of 46 patients with sporadic ALS and 19 control subjects. In ALS patients, FA values in the internal capsule, frontal white matter, genu and splenium of the corpus callosum (p<0.001), parietal and temporal lobe white matter, and posterior cingulum (p<0.05) were significantly lower than in controls. FA values in frontal white matter were lower than in parietal white matter (p<0.001). Decreased FA values in frontal, parietal, and temporal white matter, and the genu of the corpus callosum, correlated significantly with those in the internal capsule (r=0.66 and p<0.001, r=0.47 and p=0.001, r=0.33 and p=0.021, r=0.41 and p=0.005, respectively). No such correlations were found for FA values in other white matter areas or in controls. Patient FA values generally were not correlated with disease duration. DTI demonstrated more widespread involvement of the cerebral white matter in ALS patients than previously believed. The severity of involvement in the frontal, temporal and parietal white matter correlated with severity in the pyramidal tract.

  566. Endolymphatic space imaging in patients with delayed endolymphatic hydrops.

    Kasai Sachio; Teranishi Masaaki; Katayama Naomi; Sugiura Makoto; Nakata Seiichi; Sone Michihiko; Naganawa Shinji; Nakashima Tsutomu

    Acta Otolaryngol   Vol. 129   page: 1163-1174   2009.11

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  567. 鼓室内ガドリニウム造影剤注入による内耳内リンパ水腫の可視化

    長縄慎二

    映像情報 medical   Vol. 41 ( 10 ) page: 967-1006   2009.9

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  568. Lymphoplasmacytic sclerosing cholangitis: assessment of clinical, CT, and pathological findings.

    Itoh Shigeki; Nagasaka T; Suzuki Koujiro; Satake Hiroko; Ota Toyohiro; Naganawa Shinji

    Clin Radiol   ( 64 ) page: 1104-1114   2009.9

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  569. Comparisons of I-123 diagnostic and I-131 post-treatment scans for detecting residual thyroid tissue and metastases of differentiated thyroid cancer.

    IWANO SHINGO,KATO KATSUHIKO, NIHASHI TAKASHI,ITO SHIGEKI, TACHI YASUSHI, NAGANAWA SHINJI

    Ann Nucl Med   Vol. 2009 ( sep ) page: 25   2009.9

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  570. Individual Differences in the Permeability of the Round Window: Evaluating the Movement of Intratympanic Gadolinium Into the Inner Ear.

    Yoshioka M, Naganawa S, Sone M, Nakata S, Teranishi M, Nakashima T

    Otol Neurotol   Vol. 30 ( 5 ) page: 645-648   2009.8

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  571. MRIは画像診断の中心になっていくべき象徴的存在である

    長縄慎二

    月刊 新医療   Vol. 416 ( 8 ) page: 84-87   2009.8

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  572. Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma.

    Yamazaki M, Naganawa S, Kawai H, Nihashi T, Fukatsu H, Nakashima T

    Neuroradiology   Vol. in press   2009.8

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  573. 3T MR

    長縄慎二

      Vol. 2009 ( 11 ) page: 151-160   2009.8

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  574. Stenosis of the third portion of the duodenum due to bleeding from the anterior pancreaticoduodenal artery: assessment by multiphase contrast-enhanced examination with multislice CT.

    Itoh Shigeki, Mori Yoshine, Suzuki Koujiro, Satake Hiroko, Ota Toyohiro, Naganawa Shinji

    Abdom Imaging   Vol. in press   2009.7

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  575. Stent-Graft Treatment for Bleeding Superior Mesenteric Artery Pseudoaneurysm After Pancreaticoduodenectomy.

    Suzuki K, Mori Y, Komada T, Matsushima M, Ota T, Naganawa S

    Cardiovasc Intervent Radiol.   Vol. 32 ( 4 ) page: 762-6   2009.7

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  576. MRIの’’今’’を知り、診断能を探る

    長縄慎二

    新医療   Vol. 6   page: 36-39   2009.6

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  577. Image evaluation of endolymphatic space in fluctuating hearing loss without vertigo.

    Teranishi Masaaki, Naganawa Shinji, Katayama Naomi, Sugiura Makoto, Nakata Seiichi, Sone Michiko, Nakashima Tsutomu

    Eur Arch Otorhinolaryngol   Vol. 266 ( 12 ) page: 1871-1877   2009.5

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  578. 3D-CT volumetry of the lung using multidetector row CT: comparison with pulmonary function tests.

    Iwano, Shingo; Okada, Tohru; Satake, Hiroko; Naganawa, Shinji

    Acad Radiol   ( 16 ) page: 205-256   2009.3

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    RATIONALE AND OBJECTIVES: The aim of this study was to evaluate the accuracy of measurements of lung volumes reconstructed using three-dimensional computed tomographic (CT) imaging from thin-section multidetector-row CT images compared to standard pulmonary function testing. MATERIALS AND METHODS: Preoperative three-dimensional CT images and pulmonary function test results of 64 patients with solitary pulmonary nodules who were considered candidates for lung resection were reviewed. On the three-dimensional CT images, total lung capacity (TLC(CTV)), emphysematous lung capacity (ELC(CTV)), and normal lung capacity (NLC(CTV)) were calculated. Total lung capacity (TLC), vital capacity, and forced expiratory volume in 1 second were measured using spirometry. RESULTS: There was a strong positive correlation between estimated TLC(CTV) and measured TLC values (r = 0.87, P < .001). Estimated ELC(CTV) at the threshold value of -900 Hounsfield units was negatively correlated with forced expiratory volume in 1 second (r = -0.56, P < .001). NLC(CTV) values were more strongly correlated with vital capacity values than TLC(CTV) values (r = 0.74, P < .001). CONCLUSIONS: Lung volume calculated using three-dimensional CT volumetry was well correlated with lung volume measured using spirometry. Three-dimensional CT volumetry can be used to evaluate pulmonary function.

  579. Visualization of Endolymphatic Hydrops in the Patients with Meniere's Disease by MR Imaglng after lntratympanic Administration of Gd-DTPA :Its Methods, Anatomy, Findings, and Clinical Application

      ( 2月 ) page: 60   2009.2

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  580. Changes in endolymphatic hydrops in a patient with Meniere's disease observed using magnetic resonance imaging

    Sone Michiko, Naganawa Shinji, Teranishi Masaaki, Nakata Seiichi, Katayama Naomi, Nakashima Tsutomu

    Auris Nasus Larynx   Vol. 37 ( 2 ) page: 220-222   2009

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  581. Endolymphatic Hydrops of the Labyrinth Visualized on Noncontrast MR Imaging: A Case Report.

    Naganawa, Shinji; Sone, Michihiko; Otake, Hironao; Nakashima, Tsutomu

    Magn Reson Med Sci   Vol. 8   page: 43-46   2009

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  582. 乳腺領域におけるReal-time Virtual Sonography の臨床的有用性について

    佐竹弘子、西尾明子、石垣聡子、川村麻里子、長縄慎二

    Jpn J Med Ultrasonics   Vol. 36 ( 6 ) page: 669-678   2009

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  583. Three-Dimensional Intravenous Digital Subtraction Angiography Using Flat Panel Detector System in Vascular Mapping of the External Carotid Artery: A Comparison with 3-Dimensional Computed Tomography Angiography.

    Yoshinori Tsutsumi, Kojiro Suzuki, Mitsuru Ikeda, Masataka Achiwa, Yoshine Mori, Masaya Matsushima, Satoko Ishigaki, Toyohiro Ota, Satoru Kondo, Kazuo Yoneda, Shinji Naganawa

    Current Medical Imaging Reviews   Vol. 5   page: 216-221   2009

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  584. Computer-aided diagnosis of lung cancer: definition and detection of ground-glass opacity type of nodules by high-resolution computed tomography.

    Okada, Tohru; Iwano, Shingo; Ishigaki, Takeo; Kitasaka, Takayuki; Hirano, Yasushi; Mori, Kensaku; Suenaga, Yasuhito; Naganawa, Shinji

    Jpn J Radiol   Vol. 27   page: 91-99   2009

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  585. Semi-automatic volumetric measurement of lung cancer using multi-detector CT effects of nodule characteristics.

    Iwano, Shingo; Okada, Tohru; Koike, Wataru; Matsuo, Keiji; Toya, Reiko; Yamazaki, Masahiro; Ito, Shinya; Ito, Junji; Naganwa, Shinji

    Acad Radiol   Vol. 16   page: 1179-1186   2009

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  586. CT, MR

    長縄慎二

    脳神経外科エキスパート 頭蓋底     page: 2-14   2009

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  587. A Phase I Study of Intraoperative Radiotherapy for Early Breast Cancer in Japan

    Masataka Sawaki , Shigenori Sato,Toyone Kikumori ,Shunichi Ishihara ,Yuichi Aoyama, Yoshiyuki Itoh ,Akimasa Nakao , Tsuneo Imai

    World J Surg   Vol. 33   page: 2587-2593   2009

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  588. Communication between cochlear perilymph and cerebrospinal fluid through the cochlear modiolus visualized after intratympanic administration of Gd-DTPA.

    Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Sone, Michihiko; Nakashima, Tsutomu

    Radiat Med   Vol. 26   page: 597-602   2009

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  589. Cutting edge of inner ear MRI

    SHINJI NAGANAWA ,TSUTOMU NAKASHIMA

    Acta Oto-Laryngologica   Vol. 129   page: 15-21   2009

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  590. Clinical significance of endolymphatic imaging after intratympanic gadolinium injection

    TSUTOMU NAKASHIMA, SHINJI NAGANAWA2, NAOMI KATAYAMA,MASAAKI TERANISHI, SEIICHI NAKATA, MAKOTO SUGIURA,MICHIHIKO SONE, SACHIO KASAI, MAYUMI YOSHIOKA& ASAKO YAMAMOTO

    Acta Oto-Laryngologica   Vol. 129   page: 9-14   2009

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  591. Grading of endolymphatic hydrops using magnetic resonance imaging

    TSUTOMU NAKASHIMA, SHINJI NAGANAWA, ILMARI PYYKKO,WILLIAM P.R. GIBSON, MICHIHIKO SONE, SEIICHI NAKATA,MASAAKI TERANISHI

    Acta Oto-Laryngologica   Vol. 129   page: 5-8   2009

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  592. Diagnostic Whole-Body Scanning Before Radioiodine Therapy for Pulmonary Metastases of Diffrentiated Thyroid Cancer. Predictve Value and Recommendations.

    Tachi Y, Iwano S, Kato K, Tadokoro M, Naganawa S

    Clin Nucl Med   Vol. 33 ( 12 ) page: 845-851   2008.12

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  593. Endovascular Management of Ruptured Pancreaticoduodenal Artery Aneurysms Associated with Celiac Axis Stenosis.

    Suzuki K, Tachi Y, Ito S, Maruyama K, Mori Y, Komada T, Matsushima M, Ota T, Naganawa S

    Cardiovasc Intervent Radiol   Vol. 31 ( 6 ) page: 1082-7   2008.11

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    The purpose of this study was to assess the efficacy of transcatheter arterial embolization for ruptured pancreaticoduodenal artery (PDA) aneurysms associated with celiac axis stenosis (CS). Seven patients (four men and three women; mean age, 64; range, 43-84) were treated with transcatheter arterial embolization between 2002 and 2007. They were analyzed with regard to the clinical presentation, radiological finding, procedure, and outcome. All patients presented with sudden epigastric pain or abdominal discomfort. Contrast-enhanced CT showed a small aneurysm and retroperitoneal hematoma around the pancreatic head in all patients. The aneurysms ranged from 0.3 to 0.9 cm in size. In one patient, two aneurysms were detected. The aneurysms were located in the pancreaticoduodenal artery (n = 5) and the dorsal pancreatic artery (n = 3). Embolization was performed with microcoils in all aneurysms (n = 8). N-Butyl 2-cyanoacrylate (n = 1) and gelatine particle (n = 1) were also used. Complete occlusion was achieved in four patients. In the other three patients, a significantly reduced flow to the aneurysm remained at final angiography. However, these aneurysms were thrombosed on follow-up CT within 2 weeks. And there was no recurrence of the symptoms and bleeding during follow-up (mean, 28 months; range, 5-65 months) in all patients. In conclusion, transcatheter arterial embolization for PDA aneurysms associated with CS is effective. Significant reduction of the flow to the aneurysm at final angiography may be predictive of future thrombosis.

  594. Arteriovenous malformation of the pancreas: assessment of clinical and multislice CT features.

    Ogawa H, Itoh S, Mori Y, Suzuki K, Ota T, Naganawa S

    Abdom Imaging.   Vol. Epub ahead of print   2008.10

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  595. 特集 地方会を考えるー地方会の意義;中部の場合ー

    長縄慎二

      Vol. 166   page: 8-9   2008.9

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  596. Three-Dimensional Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging Findings and Prognosis in Sudden Sensorineural Hearing Loss.

    Yoshida T, Sugiura M, Naganawa S, Teranishi M, Nakata S, Nakashima T.

    Laryngoscope   Vol. 118 ( 8 ) page: 1433-7   2008.8

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  597. Imaging analysis in cases with inflammation-induced sensorineural hearing loss.

    Sone Michiko, Mizuno Terukazu, Naganawa Shinji, Nakashima Tsutomu

    Acta Otolaryngol   Vol. 8   page: 1-5   2008.8

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  598. Focal inflammation in the embryological ventral pancreas: assessment using CT and MRI.

    Itoh, S; Suzuki, K; Kawai, H; Naganawa, S

    Clin Radiol   Vol. 63   page: 433-441   2008.4

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  599. Cognitive impairments in multiple system atrophy: MSA-C vs MSA-P.

    Kawai, Y; Suenaga, M; Takeda, A; Ito, M; Watanabe, H; Tanaka, F; Kato, K; Fukatsu, H; Naganawa, S; Kato, T; Ito, K; Sobue, G

    Neurology   Vol. 70   page: 1390-1396   2008.4

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    We evaluated comprehensive neuropsychological tests and regional brain blood flow to compare cognitive dysfunction between two types of multiple system atrophy: predominant cerebellar ataxia (MSA-C) and predominant parkinsonism (MSA-P). METHODS: Twenty-one patients with MSA-C, 14 patients with MSA-P, and 21 age- and education-matched control subjects were subjected to neuropsychological tests and SPECT. The neuropsychological tests examined general cognition, verbal and visual memory, working memory, visuospatial and constructional ability, language, executive function, depression, and anxiety, while SPECT analysis examined brain perfusion. RESULTS: Patients with MSA-P showed severe involvement of visuospatial and constructional function, verbal fluency, and executive function compared with control subjects. Patients with MSA-C showed involvement only in visuospatial and constructional function compared with control subjects and a milder degree of involvement compared with patients with MSA-P. Patients with MSA-P tended toward a wide and severe impairment in cognitive function compared with patients with MSA-C. In addition, neuropsychological impairment in patients with MSA-P was significantly correlated with a decrease in prefrontal perfusion. This significant relation was not correlated to other factors such as age, education, and severity of cerebellar ataxia and parkinsonism, which are relevant factors associated with cognitive performance. CONCLUSIONS: Patients with multiple system atrophy-parkinsonism show more severe and more widespread cognitive dysfunctions than patients with multiple system atrophy-cerebellar ataxia. Our results also indicate that cognitive dysfunction in patients with multiple system atrophy-parkinsonism may be associated with prefrontal involvement.

  600. *Separate visualization of endolymphatic space, perilymphatic space and bone by a single pulse sequence; 3D-inversion recovery imaging utilizing real reconstruction after intratympanic Gd-DTPA administration at 3 Tesla.

    Naganawa S, Satake H, Kawamura M, Fukatsu H, Sone M, Nakashima T

    Eur Radiol   Vol. 18 ( 5 ) page: 920-924   2008.3

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  601. *Imaging of Endolymphatic and Perilymphatic Fluid at 3T After Intratympanic Administration of Gadolinium-Diethylene-Triamine Pentaacetic Acid.

    Naganawa S, Sugiura M, Kawamura M, Fukatsu H, Sone M, Nakashima T

    AJNR Am J Neuroradiol   Vol. 29 ( 4 ) page: 724-726   2008.1

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    SUMMARY: By optimizing the inversion time of a 3D inversion-recovery turbo spin-echo sequence at 3T, we obtained separate images of endolymphatic and perilymphatic space 24 hours after intratympanic administration of gadolinium contrast material. In patients with Meniere disease, endolymphatic hydrops were detected not only in the cochlea but also in the vestibule. Fusion of the 2 types of images visualized the entire fluid space of the labyrinth and the spatial relationship of the 2 spaces.

  602. Arterial Spin Labeling(syngo ASL) Case Report from Nagoya University

    Shinji Naganawa

    MAGNETON Flash     page: 26-33   2008.1

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  603. Neuroendocrine tumor in the breast.

    Ogawa H, Nishio A, Satake H, Naganawa S, Imai T, Sawaki M, Yamamoto E, Miyata T.

    Radiat Med   Vol. 26 ( 1 ) page: 28-32   2008.1

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    A 34-year-old woman with a past history of a carcinoid tumor in the right ovary presented with a right breast mass found on contrast-enhanced computed tomography (CT) of the chest. She was asymptomatic, and her blood tests were normal. The mass measured about 2 cm. Mammography showed a lobular, circumscribed, high-density mass without microcalcifications in the upper outer quadrant of the right breast. Ultrasonography showed an irregular mass with both hypoechoic and hyperechoic components with increased vascularity. The mass was well enhanced on contrast-enhanced CT and dynamic magnetic resonance imaging. At the same time, a well-enhanced small nodule was detected in the pouch of Douglas. Both of the tumors were resected, and a primary breast neuroendocrine tumor (solid neuroendocrine carcinoma) and peritoneal dissemination of the ovarian carcinoid tumor were diagnosed.

  604. Development and evaluation of a novel lossless image compression method (AIC: artificial intelligence compression method) using neural networks as artificial intelligence.

    Fukatsu, Hiroshi; Naganawa, Shinji; Yumura, Shinnichiro

    Radiat Med   Vol. 26   page: 120-128   2008

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  605. 内耳MRIの最前線

    長縄慎二

    臨床放射線 vol.53 No.11   Vol. 23 ( 11 ) page: 1324-1333   2008

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  606. Imaging endolymphatic hydrops at 3 tesla using 3D-FLAIR with intratympanic Gd-DTPA administration.

    Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Fukatsu, Hiroshi; Sone, Michihiko; Nakashima, Tsutomu

    Magn Reson Med Sci   Vol. 7   page: 85-91   2008

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  607. Intraductal papillary mucinous neoplasm of the pancreas: assessment of the likelihood of invasiveness with multisection CT.

    Ogawa, Hiroshi; Itoh, Shigeki; Ikeda, Mitsuru; Suzuki, Kojiro; Naganawa, Shinji

    Radiology   Vol. 248   page: 876-886   2008

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  608. Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging investigation of inner ear disturbances in cases of middle ear cholesteatoma with labyrinthine fistula

    Sone M, Mizuno T, Sugiura M, Naganawa S, Nakashima T.

    Otol Neurotol.   Vol. 28 ( 8 ) page: 1029-33   2007.12

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    To investigate the cause of inner ear disturbances in cases of middle ear cholesteatoma with labyrinthine fistula. SETTING: University hospital. STUDY DESIGN: Prospective case study. PATIENTS: Eight patients who were scheduled to undergo surgery for middle ear cholesteatoma with labyrinthine fistula were included in this study. INTERVENTION: Imaging analysis was performed using a 3-dimensional fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging sequence. MAIN OUTCOME MEASURES: Three-dimensional FLAIR findings were compared with clinical symptoms associated with inner ear disturbance and surgical observations of the fistula. RESULTS: Three-dimensional FLAIR in 6 patients revealed areas of high signal intensity in the inner ears on the affected sides and areas with increased signal after the administration of gadolinium, especially in cases accompanied by acute sensorineural hearing loss. These images were considered to be indicative of breakdown of the blood-labyrinth barrier due to middle ear cholesteatoma. This finding was also present in a patient with no clinical symptoms of inner ear disturbances. CONCLUSION: Three-dimensional FLAIR images of the inner ear are valuable in evaluating labyrinthine fistula in patients with cholesteatoma. Future studies are needed to better understand the role of 3-dimensional FLAIR in predicting the severity of inner ear disturbance.

  609. Vestibular aqueduct in sudden sensorineural hearing loss

    Sugiura M, Naganawa S, Ishida IM, Teranishi M, Nakata S, Yoshida T, Nakashima T

    J Laryngol Otol   Vol. 26   page: 1-6   2007.11

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    To evaluate the vestibular aqueduct in patients with sudden sensorineural hearing loss.Methods:We evaluated 19 patients (12 men and seven women; age range, 22-79 years) with unilateral sudden sensorineural hearing loss, using computed tomography and magnetic resonance imaging. All these patients had unilateral sudden sensorineural hearing loss. We also evaluated 47 control subjects (22 men and 25 women; age range, 22-79 years).Results:In sensorineural hearing loss affected ears, the width of the vestibular aqueduct at the midpoint and at the operculum was significantly greater than that in contralateral ears or in control ears. The width of the vestibular aqueduct at the midpoint and the operculum did not correlate with the audiometric threshold or the audiogram configuration. Contrast enhancement of the ipsilateral endolymphatic sac was observed in 17 of 19 patients with sudden sensorineural hearing loss (89 per cent). Eleven of these 17 patients also showed enhancement on the contralateral side, but no patient showed enhancement only on the contralateral side. In sensorineural hearing loss affected ears, the width of the vestibular aqueduct did not differ significantly between those patients with and without enhancement.Conclusions:The vestibular aqueducts of sudden sensorineural hearing loss affected ears are wider than those of controls. Precise imaging and evaluation of the inner ear is essential when investigating the pathological conditions responsible for sudden sensorineural hearing loss.

  610. RVS(Real-time Virtual Sonography)技術の乳腺領域への応用

    佐竹弘子、西尾明子、石垣聡子、福原理恵子、島本佳寿広、今井常夫、小田高司、菊森豊根、澤木正孝、長縄慎二

    乳癌の臨床   Vol. 22 ( 5 ) page: 438(86)-439(87)   2007.10

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  611. Comparison of 18F-FDG PET and bone scintigraphy in detection of bone metastasesof thyroid cancer. Reviewed

    Ito S, Kato K, Ikeda M, Iwano S, Makino N, Tadokoro M, Abe S, Nakano S,Nishino M, Ishigaki T, Naganawa S.

    J Nucl Med.   Vol. 48 ( 6 ) page: 889-895   2007.6

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  612. Usefulness of FDG PET for diagnosis and radiotherapy of the patient with malignant lymphoma involving bone marrow. Reviewed

    Nihashi, Takashi; Hayasaka, Kazumasa; Itou, Toshihide; Sobajima, Takashi; Kato, Rikio; Ito, Kengo; Ito, Yoshiyuki; Ishigaki, Takeo; Naganawa, Shinji

    Radiat Med   Vol. 25 ( 3 ) page: 130-4   2007.4

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    We experienced a case of relapsed malignant lymphoma with multiple bone marrow or bone lesions. The case was diagnosed as follicular lymphoma by cytological biopsy of the right iliac bone, with (67)Ga scintigraphy showing abnormal, intense uptake in multiple bones. After about 10 months of systemic chemotherapy, a relapse was suspected because of pain in the bilateral legs and a high level of lactate dehydrogenase. Assessment of the lesions in the patient was difficult by computed tomography because the affected sites were localized mainly in the bone marrow. (18)F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) was useful for detecting accurately the relapse sites in the bone marrow and enabled us to determine the field for radiotherapy. There are only a few reports of FDG-PET findings for such bone marrow malignant lymphomas. Therefore, we report the findings of FDG-PET for this case and review some of the literature about bone marrow lymphomas.

  613. Usefulness of combined fractional anisotropy and apparent diffusion coefficient values for detection of involvement in multiple system atrophy. Reviewed

    Ito, Mizuki; Watanabe, Hirohisa; Kawai, Yoshinari; Atsuta, Naoki; Tanaka, Fumiaki; Naganawa, Shinji; Fukatsu, Hiroshi; Sobue, Gen

    J Neurol Neurosurg Psychiatry   Vol. 78   page: 722-728   2007.3

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    OBJECTIVE: To determine whether apparent diffusion coefficient (ADC) values and fractional anisotropy (FA) values can detect early pathological involvement in multiple system atrophy (MSA), and be used to differentiate MSA-P (multiple system atrophy if parkinsonian features predominate) from Parkinson's disease (PD). METHODS: We compared ADC and FA values in the pons, cerebellum and putamen of 61 subjects (20 probable MSA patients, 21 age matched PD patients and 20 age matched healthy controls) using a 3.0 T magnetic resonance system. RESULTS: ADC values in the pons, cerebellum and putamen were significantly higher, and FA values lower in MSA than in PD or controls. These differences were prominent in MSA lacking dorsolateral putaminal hyperintensity (DPH) or hot cross bun (HCB) sign. In differentiating MSA-P from PD using FA and ADC values, we obtained equal sensitivity (70%) and higher specificity (100%) in the pons than in the putamen and cerebellum. In addition, all patients that had both significant low FA and high ADC values in each of these three areas were MSA-P cases, and those that had both normal FA and ADC values in the pons were all PD cases. Our diagnostic algorithm based on these results accurately diagnosed 90% of patients with MSA-P. CONCLUSION: FA and ADC values detected early pathological involvement prior to magnetic resonance signal changes in MSA. In particular, low FA values in the pons showed high specificity in discriminating MSA-P from PD. In addition, combined analysis of both FA and ADC values in all three areas was more useful than only one.

  614. 3D-FLAIR MRI findings in a patient with Ramsay Hunt syndrome. Reviewed

    Sugiura M, Naganawa S, Nakata S, Kojima S, Nakashima T

    Acta Otolaryngol   Vol. 127 ( 5 ) page: 547-549   2007

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    Three-dimensional, fluid-attenuated inversion recovery (3D-FLAIR) of magnetic resonance imaging (MRI) has recently been developed to detect hemorrhage or high concentrations of protein. We present a patient with Ramsay Hunt syndrome, in whom high signals in the cochlear and vestibular apparatus were identified with 3D-FLAIR. The high signal areas in 3D-FLAIR were not detected by T1- and T2-weighted MRI in this case. This is the first report of high concentrations of protein in the inner ear in Ramsay Hunt syndrome using 3D-FLAIR, and suggests that high concentrations of protein in the inner ear are associated with hearing deterioration in some patients with Ramsay Hunt syndrome. 3D-FLAIR could be a useful diagnostic tool in the early stages of Ramsay Hunt syndrome.

  615. *Visualization of endolymphatic hydrops in patients with Meniere's disease. Reviewed

    Nakashima T, Naganawa S, Sugiura M, Teranishi M, Sone M, Hayashi H, Nakata S, Katayama N, Ishida IM

    Laryngoscope   Vol. 117 ( 3 ) page: 415-420   2007

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    OBJECTIVE: Recently, there have been many reports of intratympanic gentamicin therapy for the treatment of intractable Meniere's disease. Intratympanic administration of steroids has also been used to treat sudden sensorineural hearing loss. We attempted to visualize how the intratympanically administered drug enters the inner ear. METHODS: Gadolinium hydrate diluted eightfold with saline was injected intratympanically through the tympanic membrane using a 23 G needle in nine patients with inner ear diseases. With a 3 Tesla magnetic resonance imaging (MRI) unit, three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) imaging was performed. RESULTS: 3D-FLAIR MRI clearly revealed that the gadolinium entered the perilymphatic space and delineated the perilymphatic and endolymphatic spaces of the inner ear. In patients with endolymphatic hydrops, the perilymphatic space surrounding the endolymph was small or had disappeared. Gadolinium appeared first in the scala tympani of the basal turn of the cochlea and the perilymphatic space of the vestibule. One day after the intratympanic injection of gadolinium, the gadolinium was observed in almost all parts of the perilymph. Six days after the intratympanic injection, the gadolinium had almost disappeared from the inner ear. CONCLUSION: We reported the first visualization of endolymphatic hydrops in patients with Meniere's disease. The relationship between the image of the endolymphatic space and functional tests, such as electrocochleography and vestibular-evoked myogenic potential, must be examined in the near future. It is important for the development of intratympanic drug therapies for inner-ear diseases to investigate how the drugs enter and leave the inner ear.

  616. 【マルチモダリティによるHead & Neck Imaging 2007 臨床編 日常臨床における戦略と選択】 側頭骨・耳(中耳・内耳・外耳) 難聴とめまいにおける画像診断の現状と進歩 名古屋大学医学部附属病院

    長縄慎二

    INNERVISION   Vol. 22   page: 8-11   2007

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    難聴、めまいは病院を訪れる主訴として非常に多い。両者を合併することもある。これらの病態の診断で最も大切なのは、言うまでもなく十分な病歴聴取である。さらに聴力検査、注視眼振検査、頭位眼振検査、温度刺激試験、下位脳神経障害や中耳炎の有無を調べる耳鼻咽喉科的一般所見などの検査で引き続き診断を進め、血液検査や他の部位の画像検査で全身疾患の有無も調べる必要がある。局所つまり側頭骨の画像検査はそれらを補完する意義を持つ。側頭骨画像診断についてはCT,MRIが最も重要な画像検査であるが、本稿では側頭骨におけるCT,MRIの撮像法の原則を述べた後、病態ごとに画像診断のポイント、最近の進歩を述べ、最後に難聴における画像診断の進め方のデシジョンツリーをシェーマとしてまとめることとする。(著者抄録)

  617. 【3T MRIの最新情報】 頭部MRIの最新情報

    長縄慎二

      Vol. 10   page: 7-11   2007

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    信号雑音比的に厳しい3D-FLAIRや拡散テンソルといった特殊なコントラストを要求すると、1.5T装置では信号雑音比の不足に悩まされる。そういった厳しい領域に挑戦していくことが、確実に3T装置の有用性を表現する方法である。3D-SPACEによるFLAIR,STIR,T1強調について述べ、最近、有用性の報告の多いsusceptibility weighted image(SWI)を紹介する。(著者抄録)

  618. 側頭骨 内耳・内耳道

    長縄慎二

    日本医学放射線学会雑誌     page: 87   2007

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  619. 肺癌の類似CT画像検索CADの初期的検討

    岩野信吾, 岡田徹, 神岡祐子, 石垣武男, 長縄慎二

    日本医学放射線学会雑誌     page: 182-183   2007

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  620. 3T MRIによる磁化率強調画像(SWI)を用いた多発性硬化症の脱髄巣を走行する静脈描出頻度の検討

    久保田誠司, 川井恒, 深津博, 長縄慎二

    日本医学放射線学会雑誌     page: 188-189   2007

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  621. 遠隔画像診断クリニックにおける業務分析と課題

    村瀬詠子, 深津恵理子, 石垣武男, 古賀佑彦, 加藤克彦, 深津博, 長縄慎二, 島本佳寿広

    日本医学放射線学会雑誌     page: 204-205   2007

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  622. 腹腔動脈狭窄に因る膵仮性動脈瘤に対するTAE

    鈴木耕次郎, 館靖, 森芳峰, 太田豊裕, 長縄慎二, 丸山邦弘, 伊藤信嗣, 白石里支

    日本医学放射線学会雑誌     page: 269   2007

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  623. Intraductal papillary mucinous neoplasm(IPMN)のマルチスライスCT所見の検討

    小川浩, 伊藤茂樹, 鈴木耕次郎, 長縄慎二

    日本医学放射線学会雑誌     page: 349   2007

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  624. 腹側膵領域の限局性炎症の画像所見

    伊藤茂樹, 鈴木耕次郎, 川井恒, 長縄慎二

    日本医学放射線学会雑誌     page: 350   2007

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  625. 鼓室内Gd注入による迷路内リンパ水腫の観察

    長縄慎二, 深津博, 川井恒

    日本医学放射線学会雑誌     page: 360   2007

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  626. 人工知能Neural Networkを用いたLossless画像圧縮方法(JIS圧縮法)の開発と評価

    深津博, 長縄慎二, 湯村眞一郎

    日本医学放射線学会雑誌     page: 383-384   2007

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  627. ネットワーク上の情報のorganic recirculation 比較CT interpretationにおける放射線科医に及ぼすその臨床的影響(Organic Recirculation of Information On Network: Its Clinical Impact for Radiologists in Comparative CT Interpretation)

    深津博, 長縄慎二, 長田雅和, 増沢高

    日本医学放射線学会雑誌     page: 384-385   2007

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  628. Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients.

    Nihashi, Takashi; Yatsuya, Hiroshi; Hayasaka, Kazumasa; Kato, Rikio; Kawatsu, Shoji; Arahata, Yutaka; Iwai, Katsushige; Takeda, Akinori; Washimi, Yukihiko; Yoshimura, Kumiko; Mizuno, Kanako; Kato, Takashi; Naganawa, Shinji; Ito, Kengo

    Radiat Med   Vol. 25   page: 225-262   2007

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    The purpose of this study was to evaluate and compare the diagnostic ability of 2-[(18)F]-fluoro-2-deoxy-D: -glucose (FDG) positron emission tomography (PET) and N-isopropyl-p-(123)I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD). MATERIALS AND METHODS: FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated. CONCLUSION: No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).

  629. Risk factors for neovascular glaucoma after carbon ion radiotherapy of choroidal melanoma using dose-volume histogram analysis. Reviewed

    Hirasawa, Naoki; Tsuji, Hiroshi; Ishikawa, Hitoshi; Koyama-Ito, Hiroko; Kamada, Tadashi; Mizoe, Jun-Etsu; Ito, Yoshiyuki; Naganawa, Shinji; Ohnishi, Yoshitaka; Tsujii, Hirohiko

    Int J Radiat Oncol Biol Phys   Vol. 67   page: 538-543   2007

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    PURPOSE: To determine the risk factors for neovascular glaucoma (NVG) after carbon ion radiotherapy (C-ion RT) of choroidal melanoma. METHODS AND MATERIALS: A total of 55 patients with choroidal melanoma were treated between 2001 and 2005 with C-ion RT based on computed tomography treatment planning. All patients had a tumor of large size or one located close to the optic disk. Univariate and multivariate analyses were performed to identify the risk factors of NVG for the following parameters; gender, age, dose-volumes of the iris-ciliary body and the wall of eyeball, and irradiation of the optic disk (ODI). RESULTS: Neovascular glaucoma occurred in 23 patients and the 3-year cumulative NVG rate was 42.6 +/- 6.8% (standard error), but enucleation from NVG was performed in only three eyes. Multivariate analysis revealed that the significant risk factors for NVG were V50IC (volume irradiated > or =50 GyE to iris-ciliary body) (p = 0.002) and ODI (p = 0.036). The 3-year NVG rate for patients with V50IC > or =0.127 mL and those with V50IC <0.127 mL were 71.4 +/- 8.5% and 11.5 +/- 6.3%, respectively. The corresponding rate for the patients with and without ODI were 62.9 +/- 10.4% and 28.4 +/- 8.0%, respectively. CONCLUSION: Dose-volume histogram analysis with computed tomography indicated that V50IC and ODI were independent risk factors for NVG. An irradiation system that can reduce the dose to both the anterior segment and the optic disk might be worth adopting to investigate whether or not incidence of NVG can be decreased with it.

  630. Contrast enhanced MR imaging of the brain using T1-FLAIR with BLADE compared with conventional spin echo sequence

    S.Naganawa,H.Kawai,and H.Fukatsu

    Proc.Intl.Soc.Mag.Reson.Med   Vol. 15   page: 2110   2007

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  631. 拡散テンソル画像を用いた多系統萎縮症とパーキンソン病の錐体路評価

    伊藤瑞規, 熱田直樹, 川合圭成, 渡邉宏久, 祖父江元, 長縄慎二, 深津博, 石垣武男

    臨床神経学   Vol. 46   page: 1084   2007

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  632. Parry-Romberg syndrome with a clinically silent white matter lesion. Reviewed

    Okumura A, Ikuta T, Tsuji T, Kato T, Fukatsu H, Naganawa S, Kato K, Watanabe K

    AJNR Am J Neuroradiol   Vol. 27 ( 8 ) page: 1729-1731   2006.9

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    We performed a detailed neuroimaging study in a patient with Parry-Romberg syndrome. Proton MR spectroscopy demonstrated normal spectral patterns, though conventional MR imaging revealed high-intensity areas in the entire white matter in the left hemisphere. Single-photon emission tomography showed increased perfusion in the cortex of the affected hemisphere. Pyramidal tracts and optic radiations were preserved on diffusion tensor tractography. We will correlate these neuroimaging findings with normal psychomotor development in our patient.

  633. Prompt contrast enhancement of cerebrospinal fluid space in the fundus of the internal auditory canal: observations in patients with meningeal diseases on 3D-FLAIR images at 3 Tesla. Reviewed

    Naganawa S, Sugiura M, Kawamura M, Fukatsu H, Nakashima T, Maruyama K

    Magn Reson Med Sci   Vol. 5 ( 3 ) page: 151-155   2006

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    We speculated that meningeal pathologies might facilitate the permeability of cranial nerves at the fundus of the internal auditory canal (IAC), causing prompt enhancement after administration of Gd-DTPA. Using a 3D- fluid-attenuated inversion recovery (FLAIR) sequence, we evaluated the enhancement of the cerebrospinal fluid (CSF) space in the IAC fundus 10 min after Gd-DTPA administration in patients with meningeal diseases. Twenty patients (aged 22 to 79 years) were divided into 2 groups, a group with meningeal disease comprising 9 patients with meningeal abnormalities (6, tumor dissemination; 3, infection) and a control group of 11 patients with unilateral IAC pathology whose healthy sides were included as controls. Six of the 9 patients in the group with meningeal disease showed bilateral enhancement; one showed unilateral enhancement. None of the control group showed enhancement in the healthy side. One patient with Ramsay-Hunt syndrome showed only ipsilateral enhancement. Enhancement in the IAC fundus was frequently observed in patients with meningeal disease, even just 10 min after administration of contrast agent. This enhancement in the IAC fundus was never visible on T1-weighted 3D-FLASH images.

  634. *Observation of contrast enhancement in the cochlear fluid space of healthy subjects using a 3D-FLAIR sequence at 3 Tesla. Reviewed

    Naganawa S, Komada T, Fukatsu H, Ishigaki T, Takizawa O

    Eur Radiol   Vol. 16 ( 3 ) page: 733-737   2006

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    In animals, the enhancement of perilymph in the cochlea has been reported using 1.25 mmol/kg of Gd-DTPA, allowing the separate visualisation of perilymph and endolymph for the diagnosis of Meniere's disease. The purpose of this study was three-fold: (1) to determine the optimal timing for detecting cochlear fluid enhancement using 3D-FLAIR (fluid-attenuated inversion recovery) after intravenous administration of 0.1 mmol/kg of Gd-DTPA in healthy human subjects; (2) to examine the reliability of enhancement in multiple healthy subjects; and (3) to investigate whether endolymph and perilymph space can be visually discriminated. In two healthy subjects, 3D-FLAIR images were obtained before, immediately after and 2 h, 4 h and 6 h after the injection. Three more healthy subjects were scanned before and 4 h after the injection. In all four ears of the initial two subjects, cochlear fluid was found to be most intensely enhanced 4 h after the injection. In all of the additional three subjects, the cochlear fluid signal had increased after 4 h from injection. However, visual differentiation of endolymph and perilymph fluid could not be achieved. Using 3D-FLAIR and Gd-DTPA, cochlear fluid enhancement can be observed in healthy human ears, even with a single dose of contrast-medium injection.

  635. Relationship between CT densitometry with a slice thickness of 0.5 mm and audiometry in otosclerosis. Reviewed

    Kawase S, Naganawa S, Sone M, Ikeda M, Ishigaki T

    Eur Radiol   Vol. 16 ( 6 ) page: 1367-1373   2006

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    The appropriate cutoff Hounsfield unit (HU) value for the diagnosis of otosclerosis was determined and the correlation between the bone conduction threshold and the findings of computed tomography (CT) densitometry investigated. CT images, 0.5-mm thick, were evaluated in 24 ears with otosclerosis and 19 control ears. Eight regions of interest were set around the otic capsule. The mean HU values in the area anterior to the oval window (A-OW) and anterior to the internal auditory canal (A-IAC) were significantly lower in otosclerosis than in controls. Based on receiver operating characteristic (ROC) analysis, the cutoff HU value in A-OW was determined to be 2,187.3 HU. The mean HU value in retrofenestral otosclerosis was significantly lower in the area A-OW, A-IAC and around the cochlea than in controls. Based on ROC analysis, the cutoff HU value in the latter was determined to be 2,045 HU. A statistically significant correlation was found between the density of the area A-OW and the hearing level at 500 and 1,000 Hz, and between the density of the area around the cochlea and the hearing level at most frequencies. These results suggest the semi-automated diagnosis of otosclerosis may be possible.

  636. Blood flow to the promontory in cochlear otosclerosis. Reviewed

    Nakashima T, Sone M, Fujii H, Teranishi M, Yamamoto H, Otake H, Sugiura M, Naganawa S

    Clin Otolaryngol   Vol. 31 ( 2 ) page: 110-115   2006

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    OBJECTIVE: To investigate Schwartze sign with measurements of blood flow to the promontory in patients with cochlear otosclerosis. DESIGN: Prospective clinical study. SETTING: Tertiary referral centre. PARTICIPANTS: Five patients with cochlear otosclerosis and five control subjects. Significant decalcification around the cochlea was observed by computed tomography (CT) in patients with cochlear otosclerosis. However, no recognizable lesion was observed at the oval window in two patients. One patient had mixed hearing loss and four patients had sensorineural hearing loss without an air-bone gap. Main outcome measures: The relationship between CT findings and the presence or absence of Schwartze sign was investigated. Blood flow to the promontory was measured through the tympanic membrane using laser speckle flowgraphy and laser Doppler flowmetry. Results: The Schwartze sign correlated significantly with otosclerotic lesions invading the promontory. Patients with otosclerosis exhibited elevated and pulsating blood flow to the promontory with the Schwartze sign. CONCLUSIONS: Computed tomography demonstrated that cochlear otosclerosis can exist without the oval window lesion. Schwartze sign can be used as a sign of the otosclerotic invasion to the promontory. The reddening of the Schwartze sign is likely due to increased blood flow.

  637. Visualization of a high protein concentration in the cochlea of a patient with a large endolymphatic duct and sac, using three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging. Reviewed

    Sugiura M, Naganawa S, Sato E, Nakashima T

    J Laryngol Otol   Vol. 120 ( 120 ) page: 1084-1086   2006

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  638. Inner ear hemorrhage in systemic lupus erythematosus. Reviewed

    Sugiura M, Naganawa S, Teranishi M, Sato E, Kojima S, Nakashima T

    Laryngoscope   Vol. 116 ( 5 ) page: 826-828   2006

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    A 33-year-old man had systemic lupus erythematosus (SLE) with anticardiolipin antibody. At the age of 40 years, he experienced bilateral hearing deterioration. The three-dimensional fluid-attenuated inversion recovery of magnetic resonance imaging showed high signals bilaterally in the cochlea and vestibule. He was diagnosed with bilateral inner ear hemorrhage on the basis of the presence of anticardiolipin antibody. This is the first published case of inner ear hemorrhage in a patient with SLE. Our findings suggest that inner ear hemorrhage is associated with hearing deterioration in some patients with SLE.

  639. Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging findings in patients with sudden sensorineural hearing loss. Reviewed

    Sugiura M, Naganawa S, Teranishi M, Nakashima T

    Laryngoscope   Vol. 116 ( 8 ) page: 1451-1454   2006

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    OBJECTIVE: To evaluate the inner ear in sudden sensorineural hearing loss (SNHL) using three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging (MRI) at 3 Tesla (T). BACKGROUND: 3D-FLAIR MRI has recently been developed to detect high concentrations of protein or hemorrhage. Application of this method to sudden SNHL has not been described. METHODS: We used 3D-FLAIR at 3 T with and without gadolinium enhancement to evaluate eight patients with sudden SNHL. RESULTS: In four of eight ears with idiopathic sudden SNHL, high precontrast signals were observed within the inner ear on 3D-FLAIR. The high-signal areas observed on 3D-FLAIR were not detected by T1- or T2-weighted MRI in any of these patients. In one of these four ears, significant gadolinium enhancement was observed on 3D-FLAIR. CONCLUSION: Half the patients with sudden SNHL examined had high signals in the SNHL-affected ear on 3D-FLAIR at 3 T. High precontrast signals in the inner-ear fluid space may reflect minor hemorrhage, or an increased concentration of protein that had passed through blood vessels with increased permeability, or had originated from disrupted cells in the inner ear. Gadolinium enhancement in one ear suggested the breakdown of the blood-labyrinth barrier. 3D-FLAIR MRI should contribute markedly to the elucidation of pathologic conditions in the inner ears of patients with idiopathic sudden SNHL.

  640. Lateral semicircular canal and vertigo in patients with large vestibular aqueduct syndrome. Reviewed

    Ishida IM, Sugiura M, Nakashima T, Naganawa S, Sato E, Sugiura J, Yoshino T

    Otol Neurotol   Vol. 27 ( 6 ) page: 788-792   2006

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    OBJECTIVE: To evaluate the hypothesis that there are differences in the morphology of the lateral semicircular canal (LSCC) between patients with large vestibular aqueduct syndrome (LVAS) and control subjects and to investigate the clinical implications of these differences. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. PATIENTS: Nine patients (two male patients and seven female patients; age range, 8-54 yr) with LVAS (one patient had unilateral LVAS, and eight patients had bilateral LVAS). Five patients had vertigo, and four patients, including the one with unilateral LVAS, did not have vertigo. MAIN OUTCOME MEASURES: The area of the LSCC was traced on the magnetic resonance imaging console and compared between LVAS patients and 12 control subjects who did not have sensorineural hearing loss. The LSCC fluid-containing area was divided by the sum of the LSCC inner area and the LSCC fluid-containing area for evaluation of the degree of the LSCC dysplasia. RESULTS: The LSCC fluid-containing ratio was significantly larger in LVAS patients than in control subjects. Moreover, the LSCC fluid-containing ratio was significantly larger in the eight ears with vertigo than in the nine ears without vertigo. There was no relationship between hearing level and the LSCC fluid-containing ratio. CONCLUSION: Patients with LVAS may have disturbed morphogenesis of both membranous and bony labyrinths. Our results reveal that the morphology of semicircular canals is clinically associated with vertigo.

  641. 3D-FLAIR magnetic resonance imaging in the evaluation of mumps deafness. Reviewed

    Otake H, Sugiura M, Naganawa S, Nakashima T

    Int J Pediatr Otorhinolaryngol   Vol. 70 ( 12 ) page: 2115-2117   2006

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    A 6-year-old boy suffered acute profound right side deafness after his classmates had mumps. Although his salivary glands were not swollen, he had high levels of anti-mumps IgM and IgG antibodies. The three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) procedure applied to magnetic resonance imaging (MRI) showed high signals in the right cochlea and vestibule. This indicated hemorrhage or a high concentration of protein in the right inner ear. This is the first case demonstrating a high 3D-FLAIR MRI signal of the inner ear in a patient with mumps deafness. Our findings suggest that 3D-FLAIR MRI may help to identify and define labyrinthitis in mumps deafness.

  642. 【超音波画像診断の最新技術と臨床活用 最新技術をキーワードで斬る】 RVS RVS(Real-time Virtual Sonography)技術の乳腺領域への臨床応用

    佐竹弘子, 澤木明子, 長縄慎二, 三竹毅, 荒井修

      Vol. 6   page: 56-59   2006

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  643. クローズアップ 名古屋大学医学部附属病院

    長縄慎二,深津博、米田和夫

    新医療   Vol. 33 ( 9 ) page: 87-87   2006

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  644. 画像診断機器の進歩での3D画像の有用性 3テスラMRIを中心に

    長縄慎二

    新医療   Vol. 33 ( 8 ) page: 102-104   2006

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  645. シーメンス旭 超高磁場MRIシステムの現状と将来

    長縄慎二

    Japan medical society   Vol. 112 ( 2 ) page: 75-77   2006

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  646. 拡散テンソル画像を用いた多系統萎縮症の錐体路評価

    伊藤瑞規, 熱田直樹, 渡邉宏久, 祖父江元, 長縄慎二, 深津博, 石垣武男

    臨床神経学   Vol. 46   page: 110   2006

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  647. 非造影検査でどこまで診断に迫れるか? 高磁場MRI

    長縄慎二

    断層映像研究会雑誌   Vol. 33   page: 20-21   2006

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  648. 3Teslaにおける3D-FLAIRを用いた蝸牛リンパ液の造影効果の観察

    長縄慎二, 深津博, 石垣武男

    日本医学放射線学会雑誌     page: 263   2006

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  649. 【脊髄小脳変性症研究の最近の進歩】 孤発性脊髄小脳変性症 多系統萎縮症のMRI画像

    渡辺宏久, 伊藤瑞規, 熱田直樹, 長縄慎二, 深津博, 祖父江元

    神経研究の進歩   Vol. 50   page: 397-407   2006

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  650. 【ここまで進歩した3D画像システム】 臨床での効果が大きい3D画像診断 画像診断機器の進歩でもたらされた3D画像の有用性 3テスラMRIを中心に

    長縄慎二

    新医療   Vol. 33   page: 102-104   2006

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  651. 【3D-SPACEの臨床応用】 さまざまなコントラストのisotropic data撮像

    長縄慎二

      Vol. 21   page: 02-04   2006

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  652. 【64列CTがもたらした影響を検証する】 CTがもたらした診療・経営への効果 64スライスCTの普及がもたらす画像診断の進歩と機器運用の変化

    長縄慎二

    新医療   Vol. 33   page: 56-59   2006

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  653. 著明な肉芽形成が見られた腫瘤形成性膵炎の一例

    中根俊樹, 鈴木耕次郎, 長縄慎二, 伊藤茂樹, 金住直人, 下山芳江

    日本医学放射線学会雑誌     page: 465   2006

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  654. マルチスライスCTによる無症候性の腹腔動脈狭窄の検討

    森芳峰, 鈴木耕次郎, 佐竹弘子, 太田豊裕, 長縄慎二, 伊藤茂樹

    日本医学放射線学会雑誌     page: 472   2006

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  655. Medical Image Processing & Analysis Technology デジタル時代の医用画像情報技術セミナー イメージング&応用編 医療情報が拓く新しい世界 近未来型画像診断レポートシステムの最先端

    深津博, 石垣武男, 長縄慎二, 岩朝昭, 長田雅和, 牧野恭子, 早川ルミ

      Vol. 21   page: 58-63   2006

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    近年、画像診断の機器および技術の進歩はめざましく、得られた画像はほぼすべての領域において、客観的で具体的な診断情報を提供する重要なツールとなっている。しかしながら一方で、マルチスライスCTをはじめとする高速な診断機器の登場によって1検査あたりの画像が1500枚を超えるような大量のデータが日常的に発生している。また、最新のMRIやPETのように、画像の解釈に専門的な機器や物理的・化学的な知識が要求されることも珍しくない。検査をオーダする臨床医は、画像診断の結果を患者やその家族に説明したり、その結果から治療方針を決定する。さらに、治療した結果の効果判定を行い次の治療方針を立てたりすることを日常的に行っており、その際、診断内容に関して完全に理解していないと自信を持って次の行為を行うことができない。外来診療での短い診察時間内で、上記のような大量で複雑な画像情報を一から観察して解釈することは、現実的には不可能なため、放射線科医の診断レポートが必要となる。放射線科医は、専門的な知識や技術をもってすべての画像を観察して解釈し、その結果を診断レポートとしてまとめて臨床医に提供する。診断レポートはカルテの一部となる公式文書であるため、医療訴訟の際にも証拠として扱われる重要な文書である。放射線科医は診断レポート内において、所見の存在やその意義、重要性や確信度、鑑別診断や次に必要とされる処置・検査などについてのアドバイスなどを含め、その診断内容を正確に伝達することに細心の注意を払っているが、短い診療時間内で診断レポートを読んだだけでは、記載された所見に対応する画像を捜し出すのは容易ではない。本稿では、雑多な日常業務の中で行われる診断レポート作成を支援するために、われわれが開発した「Hyperlink Report」、「Report Checker」の有用性について述べる。(著者抄録)

  656. 【膵疾患の画像診断 最近のトレンド】 マルチスライスCT診断

    伊藤茂樹, 石垣聡子, 鈴木耕次郎, 岩野信吾, 長縄慎二

    臨床画像   Vol. 22   page: 1334-1342   2006

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  657. *Differentiation of noncancerous tissue and cancer lesions by apparent diffusion coefficient values in transition and peripheral zones of the prostate. Reviewed

    Sato C, Naganawa S, Nakamura T, Kumada H, Miura S, Takizawa O, Ishigaki T

    J Magn Reson Imaging   Vol. 21 ( 3 ) page: 258-262   2005.3

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    PURPOSE: To compare the apparent diffusion coefficient (ADC) values of prostate cancer in both the peripheral zone (PZ) and the transition zone (TZ) with those of benign tissue in the same zone using echo-planar diffusion weighted imaging with a parallel imaging technique. MATERIALS AND METHODS: A total of 29 consecutive male patients (mean age 61.3 years, age range 53-88 years) with suspected prostate cancer were referred for MR imaging. All patients underwent transrectal ultrasound (TRUS)-guided biopsy of the prostate after MR imaging at 1.5 T, including ADC. For each patient, seven to 10 specimens were obtained from the prostate, and regions of interest (ROIs) were drawn on the ADC map by referring to the urologist's illustration of TRUS-guided biopsy sites. ADC values of cancerous tissue in both the PZ and TZ were compared to those of noncancerous tissue in the same zone. RESULTS: Out of 29 patients, 23 had cancer tissue. In the 23 patients with cancer, the mean ADC value of all cancer ROIs and that of all noncancer ROIs, respectively, were 1.11 +/- 0.41 x 10(-3) and 1.68 +/- 0.40 x 10(-3) mm(2)/second (values are mean +/- SD) (P < 0.01). The mean ADC value of TZ cancer ROIs and that of TZ noncancer ROIs, respectively, were 1.13 +/- 0.42 x 10(-3) and 1.58 +/- 0.37 x 10(-3) mm(2)/second (P < 0.01). CONCLUSIONS: ADC measurement with a parallel imaging technique showed that ADC values of prostate cancer in both the PZ and TZ were significantly lower than those of benign tissue in the PZ and TZ, respectively.

  658. Diffusion-weighted imaging of the liver: technical challenges and prospects for the future. Reviewed

    Naganawa S, Kawai H, Fukatsu H, Sakurai Y, Aoki I, Miura S, Mimura T, Kanazawa H, Ishigaki T

    Magn Reson Med Sci   Vol. 4 ( 4 ) page: 175 - 186   2005

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    Diffusion-weighted imaging (DWI) has recently been attempted in the abdominal region. We review diffusion-weighted images of the liver, especially from the technical point of view. We discuss selection of pulse sequence parameters, effects of anti-breathing motion technique, tips for measuring apparent diffusion coefficient (ADC), and utility of superparamagnetic iron oxide (SPIO), showing clinical cases, including those at 3T. Our current trial of new pulse sequencing, such as SPIO-mediated breath-holding black-blood fluid-attenuated inversion recovery (BH-BB-FLAIR), imaging is shown. Some prospects for the future in DWI of the liver are also stated.

  659. Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix. Reviewed

    Naganawa S, Sato C, Kumada H, Ishigaki T, Miura S, Takizawa O

    Eur Radiol   Vol. 15 ( 1 ) page: 71-78   2005

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    A relation between apparent diffusion coefficient (ADC) values and tumor cellular density has been reported. The purpose of this study was to measure the ADC values of cervical cancers in the uterus and compare them with those of normal cervical tissues, and to test whether ADC could differentiate between normal and malignant cervical tissues in the uterus. Twelve consecutive female patients with cervical cancer of the uterus and ten female patients with other pelvic abnormalities were included in this study. ADC was measured at 1.5 T with b-factors of 0, 300 and 600 s/mm2 using single-shot echo-planar diffusion-weighted imaging and a parallel imaging technique. The mean ADC value of cervical cancer lesions was 1.09+/-0.20 x 10(-3) mm2/s, and that of normal cervix tissue was 1.79+/-0.24 x 10(-3) mm2/s (P<0.0001). In nine patients treated by chemotherapy and/or radiation therapy, the mean ADC value of the cervical cancer lesion increased significantly after therapy (P<0.001). The present study showed, with a small number of patients, that ADC measurement has a potential ability to differentiate between normal and cancerous tissue in the uterine cervix. Further study is necessary to determine the accuracy of ADC measurement in monitoring the treatment response.

  660. Long-term follow-up in patients with Pendred syndrome: vestibular, auditory and other phenotypes. Reviewed

    Sugiura M, Sato E, Nakashima T, Sugiura J, Furuhashi A, Yoshino T, Nakayama A, Mori N, Murakami H, Naganawa S

    Eur Arch Otorhinolaryngol   Vol. 262 ( 9 ) page: 737-743   2005

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    Fourteen patients with a Pendred syndrome gene (Pds) mutation and three patients without the mutation were studied to evaluate long-term vestibular and auditory manifestations among patients with bilateral enlarged vestibular aqueducts (EVA). Charts were reviewed retrospectively for age, gender, otological history, presence or absence of vertigo, results of magnetic resonance imaging, relevant gene mutations and perchlorate discharge test. A missense mutation, His 723 Arg (H723R), was identified in the homozygous state in six patients and in the heterozygous state in seven patients. Another missense mutation, Tyr 410 Met (T410 M), was identified in the heterozygous state in one patient. Patients with vertigo tended to have hearing fluctuation, compared with the patients without vertigo. Patients homozygous for H723R tended to have more episodes of vertigo than the heterozygous individuals. Only one patient who was homozygous for H723R had goiter. The long-term outcome of hearing level in patients with the H723R mutation was significantly better compared with published results for patients with a Pds mutation, but not for those with the H723R mutation. Whether environmental factors or a subtype of the Pds mutation H723R are related to the long-term outcome for these patients must be clarified.

  661. Contralateral and ipsilateral responses in primary somatosensory cortex following electrical median nerve stimulation--an fMRI study. Reviewed

    Nihashi T, Naganawa S, Sato C, Kawai H, Nakamura T, Fukatsu H, Ishigaki T, Aoki I

    Clin Neurophysiol   Vol. 116 ( 4 ) page: 842-848   2005

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    OBJECTIVE: Ten healthy adult subjects were examined using functional magnetic resonance imaging (fMRI) to investigate responses in the contralateral and ipsilateral primary somatosensory cortex (SI) following electrical stimulation of the median nerve. METHODS: The right and left median nerves were stimulated alternately at the wrist in the different sessions. First, the location of the response in contralateral SI was identified following median nerve stimulation, and then, a spherical search volume with a 10mm radius centered on the region of the contralateral response was determined. Whether or not fMRI activation occurred within this sphere following ipsilateral stimulation was examined using a 3T MR imager. RESULTS: A response in contralateral SI was observed in 8 of the 10 subjects in right and left hemisphere. Responses in ipsilateral SI were observed in 6 of 8 subjects in right hemisphere, and the region of the response tended to be posterior to the contralateral region. On the other hand, in left hemisphere, the ipsilateral responses were found in three. CONCLUSIONS: In the present study, not only contralateral SI but also ipsilateral SI was activated following median nerve. The location of the ipsilateral activation was significantly more posterior than the contralateral one in right hemisphere. SIGNIFICANCE: The region of activation in ipsilateral SI was located in the posterior portion of post central gyrus, corresponding to around BA2 and 5 in human.

  662. Sudden sensorineural hearing loss associated with inner ear anomaly. Reviewed

    Sugiura M, Nakashima T, Naganawa S, Otake Y, Mukaida T, Sone M, Sato E

    Otol Neurotol   Vol. 26 ( 2 ) page: 241-246   2005

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    OBJECTIVE: This study was conducted to evaluate the frequency of inner ear anomaly in patients with sudden sensorineural hearing loss and in control subjects. STUDY DESIGN: Retrospective case review. SETTING: A tertiary referral center. PATIENTS AND INTERVENTION: We evaluated 366 patients (165 men and 201 women; age range, 3-91 yr) with sudden sensorineural hearing loss and 228 control subjects without sensorineural hearing loss using magnetic resonance imaging. Three hundred fifty-six patients had unilateral and 10 patients had bilateral sudden sensorineural hearing loss. RESULTS: Eleven (2.9%) of 376 ears with sudden sensorineural hearing loss had inner ear anomaly. Nine patients (2.5%) had inner ear anomaly associated with sudden sensorineural hearing loss, but none of the 228 control subjects had the anomaly. The current study demonstrated that the frequency of inner ear anomaly in patients with sudden sensorineural hearing loss was significantly higher than in control subjects. CONCLUSION: Our study reveals that inner ear anomaly may be associated with sudden sensorineural hearing loss in 2.5% of patients.

  663. Diffusion-weighted images of the liver: comparison of tumor detection before and after contrast enhancement with superparamagnetic iron oxide.

    Naganawa S, Sato C, Nakamura T, Kumada H, Ishigaki T, Miura S, Maruyama K, Takizawa O

    J Magn Reson Imaging   Vol. 21 ( 6 ) page: 836-840   2005

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    PURPOSE: To study the recognition of malignant lesions of the liver on diffusion-weighted images (DWI) can be improved by the administration of superparamagnetic iron oxide (SPIO). MATERIALS AND METHODS: Pre- and post-SPIO mediated DWI of the liver was compared in six patients with suspected malignant liver lesions at 1.5 Tesla using a parallel imaging technique. RESULTS: Post-SPIO DWI showed improved contrast-to-noise ratio between malignant lesions and liver. Furthermore, the spleen signal was decreased on post-SPIO DWI, thus avoiding the overlap of the spleen and left lobe of the liver on maximum intensity projections (MIP). CONCLUSION: Recognition of malignant lesions of the liver was improved by SPIO on DWI. On MIP images of DWI, SPIO helped to decrease the overlap of spleen signal on the liver in some projection angles.

  664. Hearing loss in patients with enlarged vestibular aqueduct: air-bone gap and audiological Bing test. Reviewed

    Mimura T, Sato E, Sugiura M, Yoshino T, Naganawa S, Nakashima T

    Int J Audiol   Vol. 44 ( 8 ) page: 466-469   2005

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    The Bing test is based on the principle that occlusion of the external auditory meatus improves the perception of bone-conducted sounds unless there is a conductive hearing impairment. An air-bone gap has been reported in patients with large vestibular aqueduct (LVA) syndrome without apparent middle ear dysfunction. We therefore performed the Bing test on nine patients with this syndrome to evaluate whether it is associated with an air-bone gap or middle ear dysfunction. Bone conduction thresholds did not change significantly during the Bing test in any patient. Because an air-bone gap is observed in patients with abnormal communication between the inner ear and cerebrospinal fluid through the LVA, dehiscent superior canal, or dilated inner ear meatus; we propose that a 'three windows' model (in which the abnormal communication provided by the enlarged endolymphatic duct and sac in LVA acts as the 'third window' for sound conductance) might explain the air-bone gap in such patients.

  665. 【最近の画像診断の進歩 CT,MRI,PET】 高磁場MRI

    長縄慎二

    日本医師会雑誌   Vol. 134   page: 1722-1726   2005

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  666. 第33回日本磁気共鳴医学会大会にみるBody diffusionの動向

    長縄慎二

    Innervision   Vol. 20 ( 12 ) page: 112   2005

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  667. 高磁場MRI

    長縄慎二

    日本医師会雑誌   Vol. 134 ( 9 ) page: 1722-1726   2005

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  668. 超高磁場MRIのインパクト(3T MRIをふくめて)脳以外への活用方法

    長縄慎二

    日独医報   Vol. 50 ( 3 ) page: 479-489   2005

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  669. 前立腺癌,子宮頸癌におけるADC測定の意義

    長縄慎二

    画像診断   Vol. 25 ( 6 ) page: 737-743   2005

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    DWIBSにおいての癌描出のメカニズムは十分に把握されておらず,基礎的な検討としても,現時点での臨床的な課題としても,さまざまな種類の癌のADCを測定することが重要である.前立腺癌と子宮頸癌におけるADC計測の結果と臨床的な位置付けを1.5T,3Tでの結果に基づいて解説する

  670. 電子ポスター(Cypos)元年 JRC2005を振り返って

    石垣武男 藤田広志 深津博 長縄慎二 片渕哲朗 原武史

    Innervision   Vol. 20 ( 7 ) page: 28-33   2005

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  671. 第64回日本医学放射線学会学術集会 イメージインタープリテーションセッション症例出題集

    長縄慎二、原真咲

    日本医学放射線学会誌別冊付録   Vol. 65 ( 3 ) page: 1-28   2005

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  672. 第64回日本医学放射線学会学術集会 イメージインタープリテーションセッション症例出題集

    長縄慎二、原真咲

    日本医学放射線学会誌別冊付録   Vol. 65 ( 2 ) page: 1-14   2005

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  673. 【医療環境の変化に対して放射線診療は今後どう対応すべきか 画像診断を中心に】 高度画像診断機器導入による画像診断へのインパクト 医療制度の変化を踏まえて 超高磁場MRIのインパクト(3T MRIを含めて) 脳以外への活用方法

    長縄慎二

    日独医報   Vol. 50   page: 479-489   2005

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  674. 多発性硬化症におけるIsotropic 3D FLAIR法の有用性

    末永正機, 伊藤瑞規, 熱田直樹, 渡邉宏久, 祖父江元, 深津博, 長縄慎二

    臨床神経学   Vol. 45   page: 1035   2005

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  675. 多系統萎縮症とパーキンソン病の鑑別 橋の拡散テンソル画像,拡散強調画像の有用性

    伊藤瑞規, 熱田直樹, 川合圭成, 渡邉宏久, 祖父江元, 長縄慎二, 深津博, 石垣武男

    臨床神経学   Vol. 45   page: 1168   2005

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  676. 多系統萎縮症における認知機能障害 画像との関連

    川合圭成, 伊藤瑞規, 渡邉宏久, 祖父江元, 武田章敬, 長縄慎二, 深津博, 加藤克彦, 石垣武男

    臨床神経学   Vol. 45   page: 1185   2005

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  677. Serial evaluation of diffusion tensor brain fiber tracking in a patient with severe diffuse axonal injury. Reviewed

    Naganawa S, Sato C, Ishihra S, Kumada H, Ishigaki T, Miura S, Watanabe M, Maruyama K, Takizawa O

    AJNR Am J Neuroradiol   Vol. 25 ( 9 ) page: 1553-1556   2004.10

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    Serial evaluation of diffusion tensor brain fiber tracking was performed in a 27-year-old female patient with diffuse axonal injury after a traffic accident. Although the result of brain fiber tracking was not necessarily parallel to her clinical symptoms, it may have predicted the neurologic prognosis.

  678. Rad Talk ISMRM2004

    長縄慎二

    Rad Fan   Vol. 2 ( 6 ) page: 47-56   2004.10

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  679. High-speed imaging at 3 Tesla: a technical and clinical review with an emphasis on whole-brain 3D imaging. Reviewed

    Naganawa S, Kawai H, Fukatsu H, Ishigaki T, Komada T, Maruyama K, Takizawa O

    Magn Reson Med Sci   Vol. 3 ( 4 ) page: 177-187   2004

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    Improvements to the inherently high specific-absorption rate (SAR) of high-speed imaging at 3T are necessary in order to render this method clinically feasible. Various efforts have been undertaken to improve the associated hardware and software. In this review, we focus on whole-brain isotropic 3D imaging with a turbo spin-echo sequence with variable flip-angle echo trains (3D-TSE-VFL) and present its technical and clinical features. This sequence can be used to acquire images of various contrasts including T2-weighted, fat-suppressed T2-weighted, fluid-attenuated inversion recovery (FLAIR), fat-suppressed FLAIR, and STIR (short tau inversion recovery). Various aspects of 3D-TSE-VFL are discussed, including CSF (cerebrospinal fluid) and metal artifacts, STIR contrast, small-part visualization other than brain, and the possibility of serial subtraction. Some images from clinical cases are presented.

  680. Flow ghost artifact in slice-encoding direction mimicking vestibular schwannoma in contrast-enhanced 3D spoiled gradient-echo sequence. Reviewed

    Naganawa S, Koshikawa T, Fukatsu H, Ishigaki T, Aoki I

    Eur Radiol   Vol. 14 ( 3 ) page: 496-499   2004

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    The value of MR imaging by post-contrast T1-weighted 3D spoiled gradient-echo (3D SPGR) is well established for the detection of small vestibular schwannomas in the cerebellopontine angle region. We describe a case in which a flow ghost artifact in the slice-encoding direction mimicked a vestibular schwannoma and heavily T2-weighted MR cisternography and multiplanar reconstruction images helped us to reach the correct diagnosis. In addition, we conducted a volunteer study to demonstrate that changing the k-space trajectory can reduce this artifact in post-contrast 3D SPGR images.

  681. Pre-surgical mapping of primary motor cortex by functional MRI at 3 T: effects of intravenous administration of Gd-DTPA. Reviewed

    Naganawa S, Nihashi T, Fukatsu H, Ishigaki T, Aoki I

    Eur Radiol   Vol. 14 ( 1 ) page: 112-114   2004

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    The functional magnetic resonance imaging (fMRI) is often performed at the end of a routine MRI examination during which, dependent on the clinical indication, contrast agent has been administered; however, the effects of Gd-DTPA injection on the results of blood oxygenation level dependent (BOLD)-fMRI remain unknown. The present study was conducted to investigate the effects of the intravenous administration of Gd-DTPA on the results of pre-surgical localization of the primary motor cortex by BOLD-fMRI at 3 T. Eight normal subjects were included in this study. After the anatomical scans, pre- and post-contrast fMRI scanning was performed. The number of significantly activated voxels and the mean percentage signal change were compared. The mean number of significantly activated voxels was 115.0+/-27.0 in pre-contrast runs and 90.8+/-27.1 in post-contrast runs (mean value of all 8 volunteers+/-standard deviation; p<0.05). The mean mean percentage signal change was 4.07+/-0.39 in pre-contrast runs and 3.86+/-1.91 in post-contrast runs ( p=0.16). Pre-surgical localization of the motor area by BOLD-fMRI should be performed before the administration of Gd contrast material.

  682. Optimization of diffusion-tensor MR imaging data acquisition parameters for brain fiber tracking using parallel imaging at 3 T. Reviewed

    Naganawa S, Koshikawa T, Kawai H, Fukatsu H, Ishigaki T, Maruyama K, Takizawa O

    Eur Radiol   Vol. 14 ( 2 ) page: 234-238   2004

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    The purpose of this study was to optimize the parameters of diffusion-tensor magnetic resonance imaging (DT MRI) for brain fiber tracking using a slice thickness of 2 mm, a resolution advantage allowed by the high signal-to-noise ratio at 3 T, combined with an 8-channel phased-array head coil. The b-factor, number of motion probing gradient (MPG) directions, and number of averages were varied, and the results of brain fiber tracking for the pyramidal tract and trigeminal nerve were compared qualitatively and quantitatively. The DT MRI data sufficient for brain fiber tracking in healthy subjects can be obtained in <2 min with a 2-mm slice thickness, 700-s/mm2 b-factor, 6 MPG directions, and no averaging (number of averages=1).

  683. Enlarged endolymphatic duct and sac syndrome: relationship between MR findings and genotype of mutation in Pendred syndrome gene. Reviewed

    Naganawa S, Koshikawa T, Fukatsu H, Ishigaki T, Sato E, Sugiura M, Yoshino T, Nakashima T

    Magn Reson Imaging   Vol. 22 ( 1 ) page: 25-30   2004

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    Pendred syndrome (PDS) is characterized by profound deafness in childhood, positive perchlorate challenge, and goiter. PDS is often associated with enlarged endolymphatic duct and sac (EEDS), and recently, PDS gene mutations have been reported even in those patients with EEDS without classic Pendred syndrome. In a previous report, the number of mutant alleles was correlated with the degree of subclinical thyroid abnormality, but not with hearing loss, in patients with missense mutation H723R. It also has been reported that the hearing loss in EEDS was not correlated with the EEDS volume, cochlear modiolar area, or signal intensity of the endolymphatic sac. We evaluated the correlations between the number of mutant alleles and these parameters in patients with EEDS to investigate the mechanisms underlying this condition. The study group was comprised of 16 Japanese patients with EEDS diagnosed by MR imaging. The H723R mutation was homozygous in six patients and heterozygous in six patients, with no mutation found in four patients. The modiolar area, EEDS volume, and signal intensity ratio (sac signal/cerebrospinal fluid signal) were not significantly correlated with the number of mutant alleles. PDS gene mutations may not be the only cause of EEDS, and the mechanisms underlying EEDS remain unclear.

  684. Whole-brain vascular reactivity measured by fMRI using hyperventilation and breath-holding tasks: efficacy of 3D prospective acquisition correction (3D-PACE) for head motion. Reviewed

    Naganawa S, Koshikawa T, Fukatsu H, Ishigaki T, Maruyama K, Takizawa O

    Eur Radiol   Vol. 14 ( 8 ) page: 1484-1488   2004

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    Functional MR imaging (fMRI) study using hyperventilation and breath-holding task has been reported to be one of the non-invasive methods to examine whole-brain vascular reactivity. The purpose of this study was to evaluate the efficacy of a method for 3D prospective detection and correction of head motion (3D-PACE) in a study of whole-brain vascular reactivity using hyperventilation and breath-holding tasks. Eight healthy volunteers were scanned using an fMRI protocol of hyperventilation and breath-holding task blocks at 3 T in separate runs with and without 3D-PACE. In two subjects, two more runs with and without 3D-PACE were repeated. The mean total number of activated voxels +/- standard deviation was 26,405.3+/-1,822.2 in the run with 3D-PACE and 17,329.9+/-2,766.3 in the run without 3D-PACE ( P<0.05), although there is some intersubject variation regarding the effect of 3D-PACE. In the two subjects whose performed two more runs, the number of activated voxels were smaller in the run without 3D-PACE than even in the run with 3D-PACE performed later. We conclude that 3D-PACE is beneficial for fMRI studies of whole-brain vascular reactivity induced by hyperventilation and breath-holding.

  685. Comparison of flow artifacts between 2D-FLAIR and 3D-FLAIR sequences at 3 T. Reviewed

    Naganawa S, Koshikawa T, Nakamura T, Kawai H, Fukatsu H, Ishigaki T, Komada T, Maruyama K, Takizawa O

    Eur Radiol   Vol. 14 ( 10 ) page: 1901-1908   2004

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    It has been reported that 3D-FLAIR can reduce the flow artifact resulting from cerebrospinal fluid (CSF) at 1.5 T compared to 2D-FLAIR. Flow-related artifacts tend to be worse at 3 T than at 1.5 T. The purpose of this study was to compare the CSF flow artifacts of 2D-FLAIR and 3D-FLAIR sequences at 3 T in eight healthy volunteers. The grade of CSF-related artifacts were scored through observing the perimedullary cistern, cerebellopontine angle cisterns, fourth ventricule, prepontine cistern, suprasellar cistern, ambient cisterns, sylvian fissures, third ventricle and lateral ventricles. Grading was performed on either axial or sagittal images. The CSF in-flow artifact scores were significantly higher on axial 2D-FLAIR than on axial 3D-FLAIR MPR images in all areas except the bilateral sylvian fissures, and higher on sagittal 2D-FLAIR than on sagittal 3D-FLAIR MPR images in perimedullary, bilateral CP angle and suprasellar cisterns. The CSF-related flow artifacts were significantly reduced by 3D-FLAIR, while structures in the cistern were depicted more clearly, even at 3 T. Further study is necessary to compare the clinical efficacy between 2D-FLAIR and 3D-FLAIR in depicting subtle abnormalities.

  686. MR imaging of gastric cancer in vitro: accuracy of invasion depth diagnosis.

    Sato C, Naganawa S, Kumada H, Miura S, Ishigaki T

    Eur Radiol   Vol. 14 ( 9 ) page: 1543-1549   2004

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    The purpose of this study was to evaluate the accuracy of grading cancerous invasion of the gastric wall in vitro using magnetic resonance (MR) imaging. Twelve specimens of gastric carcinoma were examined at 1.5-T using a small, loop surface coil. They were imaged within 2 days of fixation in formalin. The field of view was 30 mm; the matrix size was 256x256, and the section thickness was 2 mm. T1-weighted, T2-weighted and short inversion time inversion recovery (STIR) images were obtained. Two radiologists evaluated the MR images independently, and in discrepant cases, consensus was obtained through discussion. Findings on MR images were compared with histopathologic findings. All T1-weighted, T2-weighted and STIR images depicted the normal gastric wall as consisting of six layers. STIR images depicted normal six layers most clearly. Histologically, the cancerous invasion was found to extend into the mucosa in 4 of the 12 specimens, the submucosa in 3, the muscularis propria in 2, the subserosa in 2 and the serosa in 1. The grading by MR imaging matched the histopathologic findings for all 12 tumors. The overall accuracy was 100%. Thus, MR imaging in vitro was sufficiently accurate for grading cancerous invasion of the gastric wall.

  687. MRIの最新トッピックス 3T MRIの臨床

    長縄慎二

    映像情報メディカル   Vol. 36   page: 1056-1060   2004

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  688. 頭頚部画像診断に必要不可欠な臨床画像解剖(1)側頭骨 (内耳、内耳道)

    長縄慎二

    画像診断   Vol. 24 ( 11 ) page: 2-4   2004

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  689. Magnetic resonance imaging of endolymphatic sac in acute low-tone sensorineural hearing loss without vertigo. Reviewed

    Sugiura M, Naganawa S, Nakashima T, Misawa H, Nakamura T

    ORL J Otorhinolaryngol Relat Spec   Vol. 65 ( 5 ) page: 254-260   2003

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    The etiology of acute low-tone sensorineural hearing loss (ALHL) may be associated with deteriorated function of the endolymphatic sac. Using magnetic resonance (MR) imaging on a 1.5-tesla MR system, we evaluated the frequency of visualization and contrast enhancement of the endolymphatic sac in 25 patients (9 men and 16 women; age range 11-64 years) with ALHL and 21 control subjects. The present study demonstrated that the frequency of visualization and enhancement of the endolymphatic sac in patients with ALHL was not significantly higher than in control subjects.

  690. High-resolution T1-weighted 3D real IR imaging of the temporal bone using triple-dose contrast material. Reviewed

    Naganawa S, Koshikawa T, Nakamura T, Fukatsu H, Ishigaki T, Aoki I

    Eur Radiol   Vol. 13 ( 12 ) page: 2650-2658   2003

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  691. Contrast enhancement of the cochlear aqueduct in MR imaging: its frequency and clinical significance. Reviewed

    Nakamura T, Naganawa S, Fukatsu H, Sakurai Y, Aoki I, Ninomiya A, Nakashima T, Ishigaki T

    Neuroradiology   Vol. 45 ( 9 ) page: 626-630   2003

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    There have been no previous reports on contrast enhancement of the cochlear aqueduct in magnetic resonance imaging. The purpose of the present study was to evaluate the frequency and significance of this finding. Thirty-one patients (15 men and 16 women; age range 18-81 years) with otologic symptoms (sudden sensorineural hearing loss, vertigo, or tinnitus) were examined using contrast-enhanced imaging on a 1.5-T MR scanner. The normal ear served as the control. Two radiologists evaluated contrast enhancement in the area of the cochlear aqueduct. Forty-eight of 62 ears (77.4%) showed contrast enhancement of the cochlear aqueduct, but no significant differences in the frequency of contrast enhancement were observed between patients with and patients without vertigo, tinnitus, sensorineural hearing loss, cerebellopontine angle tumors, or a high-riding jugular bulb. In addition, no gender- or age-related differences were noted. Contrast enhancement of the cochlear aqueduct was frequently observed, but the frequency of enhancement in symptomatic ears was not significantly higher than in control ears. The results of this study may prove helpful in avoiding unnecessary examinations and potential diagnostic confusion.

  692. Disorders of cochlear blood flow. Reviewed

    Nakashima T, Naganawa S, Sone M, Tominaga M, Hayashi H, Yamamoto H, Liu X, Nuttall AL

    Brain Res Brain Res Rev   Vol. 43 ( 1 ) page: 17-28   2003

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    The cochlea is principally supplied from the inner ear artery (labyrinthine artery), which is usually a branch of the anterior inferior cerebellar artery. Cochlear blood flow is a function of cochlear perfusion pressure, which is calculated as the difference between mean arterial blood pressure and inner ear fluid pressure. Many otologic disorders such as noise-induced hearing loss, endolymphatic hydrops and presbycusis are suspected of being related to alterations in cochlear blood flow. However, the human cochlea is not easily accessible for investigation because this delicate sensory organ is hidden deep in the temporal bone. In patients with sensorineural hearing loss, magnetic resonance imaging, laser-Doppler flowmetry and ultrasonography have been used to investigate the status of cochlear blood flow. There have been many reports of hearing loss that were considered to be caused by blood flow disturbance in the cochlea. However, direct evidence of blood flow disturbance in the cochlea is still lacking in most of the cases.

  693. Pseudostenosis of the internal carotid artery in 3D time-of-flight MR angiography: effects of a magnetization transfer contrast pulse and metallic material.

    Naganawa S, Koshikawa T, Sato K, Katagiri T, Mimura T, Ishigaki T, Aoki I

    Eur Radiol   Vol. 13 ( 10 ) page: 2298-2303   2003

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    Pseudostenosis or pseudoocclusion of the internal carotid artery in 3D time-of-flight MR angiography has been reported to be caused by susceptibility artifacts due to the presence of a metallic foreign body in the subject's neck. We experimentally demonstrate that the use of a non-slice-selective magnetization transfer contrast (MTC) pulse increases the degree of pseudostenosis, whereas slice-selective MTC does not. Selective MR angiography demonstrating this phenomenon was also performed. We then report a case that exhibited this phenomenon. We conclude that the magnetic field inhomogeneity induced by metallic material causes the non-slice-selective MTC pulse to act as a local presaturation pulse. Selective MR angiography using this phenomenon can be applied on varieties of MR scanners from different vendors.

  694. Regional ADC values of the normal brain: differences due to age, gender, and laterality. Reviewed

    Naganawa S, Sato K, Katagiri T, Mimura T, Ishigaki T

    Eur Radiol   Vol. 13 ( 1 ) page: 6-11   2003

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    The purpose of this study was to evaluate the stability of measurement for apparent diffusion coefficient (ADC) values in normal brain, to clarify the effect of aging on ADC values, to compare ADC values between men and women, and to compare ADC values between right and left sides of the brain. To evaluate the stability of measurements, five normal volunteers (four men and one woman) were examined five times on different days. Then, 294 subjects with normal MR imaging (147 men and 147 women; age range 20-89 years) were measured. The ADC measurement in normal volunteers was stable. The ADC values stayed within the 5% deviation of average values in all volunteers (mean+/-standard deviation 2.3+/-1.2%). The ADC values gradually increased by aging in all regions. In thalamus, no significant difference was seen between right and left in the subjects under 60 years; however, right side showed higher values in the subjects over 60 years (p<0.01). In the subjects under 60 years, women showed higher values in right frontal, bilateral thalamus, and temporal (p<0.01); however, in the subjects over 60 years, no region showed difference between men and women. The knowledge obtained in this study may be helpful to understand the developmental and aging mechanisms of normal brain and may be useful for the future quantitative study as a reference.

  695. Imaging of a congenital perilymphatic fistula. Reviewed

    Nakashima T, Sone M, Teranishi MA, Tominaga M, Sugiura M, Naganawa S

    Int J Pediatr Otorhinolaryngol   Vol. 67 ( 4 ) page: 421-425   2003

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    A 7-year-old boy with a history of purulent meningitis and watery rhinorrhea was studied using computed tomography (CT) and magnetic resonance imaging (MRI). He had a common cavity in the left inner ear. With high-resolution heavily T2-weighted MRI, leakage of the inner ear fluid into the middle ear at the oval window area through a congenital perilymphatic fistula could be visualized. Surgery to close the fistula showed a perforation in the stapes footplate.

  696. Determination of cerebrovascular reactivity by means of FMRI signal changes in cerebral microangiopathy: a correlation with morphological abnormalities.

    Hund-Georgiadis M, Zysset S, Naganawa S, Norris DG, Von Cramon DY.

    Cerebrovasc Dis   Vol. 16 ( 2 ) page: 158-165   2003

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  697. 超高磁場磁気共鳴画像診断(MRI)について

    長縄慎二

    健康文化振興財団紀要   Vol. 38   page: 40-42   2002.4

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    はじめに

     脳ドックや腰椎の椎間板ヘルニア、膝の半月板損傷などで磁気共鳴画像診断(MRI)を受けられた方も多いと思います。MRIは磁石と電波をつかって体の断層像を得る検査です。X線CTと異なり、電離放射線被爆のない安全な検査で、この15年ほどで国内でも急速に普及しました。

     従来までは1.5T(テスラ)という磁石の強さが国内ではもっとも強いものでしたが、この3年ほどで超高磁場とよばれる3Tの製品が実用化されてきました。1Tは1万ガウスで、3Tは3万ガウスという強力な磁石です。今回は、この超高磁場MRIについて、述べてみたいと思います。

  698. Serial MR imaging studies in enlarged endolymphatic duct and sac syndrome.

    Naganawa S, Koshikawa T, Fukatsu H, Ishigaki T, Nakashima T

    Eur Radiol   Vol. 12 ( 3 ) page: 114-117   2002

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    Large vestibular aqueduct syndrome (LVAS) is a congenital disorder characterized by progressive or fluctuating sensorineural hearing loss of unknown etiology. Serial MR examinations were performed before and after the development of hearing loss in two patients with LVAS. The signal and volume of the enlarged endolymphatic sac (EES) vary even in ears with stable hearing. In ears with fluctuating hearing, changes in EES signals were observed in only one of two patients. The finding that the EES volume and signal intensity vary dynamically independently of hearing is important for future research into the pathophysiology of hearing loss in this syndrome.

  699. Regional differences of fMR signal changes induced by hyperventilation: comparison between SE-EPI and GE-EPI at 3-T. Reviewed

    Naganawa S, Norris DG, Zysset S, Mildner T

    J Magn Reson Imaging   Vol. 15 ( 1 ) page: 23-30   2002

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    PURPOSE: To evaluate whether reproducible signal change of brain tissues by hyperventilation (HV) can be seen on spin-echo (SE)-echo planar imaging (EPI) at 3-T and to examine the sensitivity of SE-EPI for measuring vascular reactivity in regions of the brain, such as the hippocampal formation, that are difficult to visualize with gradient-echo (GE)-EPI due to susceptibility artifacts. MATERIALS AND METHODS: Six healthy human subjects performed a voluntary HV task. The task design was as follows: two minutes normal breathing (rest) followed by two minutes HV, giving a basic four-minute block that was repeated three times for a total scan time of 12 minutes for one run. Each subject performed the run both for SE-EPI and GE-EPI. Statistical analysis was performed to detect the area with significant cerebrovascular reactivity. The percentage signal change was also obtained for each cerebral region. RESULTS: Both GE-EPI and SE-EPI showed globally significant signal decreases in the cerebral cortex. In GE-EPI, the frontal cortex showed a larger signal decrease than the other gray matter tissues (P < 0.05). In SE-EPI, the differences among gray matter tissues except for the hippocampal formation were not significant. The hippocampal formation showed the largest signal change (P < 0.05) in SE-EPI, but no significant signal change was observed in GE-EPI due to the presence of susceptibility artifacts. CONCLUSION: HV using SE-EPI at 3-T provides robust and reproducible signal decreases and may make the evaluation of the vascular reactivity in hippocampal formation feasible.

  700. Fast recovery 3D fast spin-echo MR imaging of the inner ear at 3 T. Reviewed

    Naganawa S, Koshikawa T, Fukatsu H, Ishigaki T, Aoki I, Ninomiya A

    AJNR Am J Neuroradiol   Vol. 23 ( 2 ) page: 229-302   2002

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    High-resolution MR imaging of the inner ear with a heavily T2-weighted 3D fast spin-echo sequence has been performed successfully at 1.5 T. However, at 3 T, the longer T1 time of CSF necessitates a longer TR, resulting in significantly prolonged imaging times. In this study, the fast recovery 3D fast spin-echo sequence, which permits the TR to be reduced while maintaining T2 contrast, was optimized at 3 T for imaging of the inner ear. The optimized sequence parameters are as follows: 1500/294 (TR/TE); echo spacing, 18.1 ms; bandwidth, 38 kHz at 512 readout; and imaging time, 13 minutes.

  701. Contrast-enhanced MR imaging of the endolymphatic sac in patients with sudden hearing loss. Reviewed

    Naganawa S, Koshikawa T, Fukatsu H, Ishigaki T, Nakashima T, Ichinose N

    Eur Radiol   Vol. 12 ( 5 ) page: 1121-1126   2002

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    Our objective was to evaluate the frequency of contrast enhancement of the endolymphatic sac in patients with sudden hearing loss. Forty consecutive patients with sudden sensorineural hearing loss (20 males and 20 females; age range 11-82 years), 40 age-matched control subjects, and 5 patients with Meniere's disease were examined using the same imaging protocol on a 1.5-T MR system. Pre- and post-contrast-enhanced T1-weighted 3D spoiled gradient-echo sequence (3D SPGR; TR/TE=23/10 ms, no. of excitations=1, flip angle=30 degrees) images were obtained using a voxel size of 0.6 x 0.7 x 0.8 mm(3). Contrast enhancement in the area of the endolymphatic sac was assessed by two radiologists, and the frequency of contrast enhancement was compared between the three study groups. Enhancement of the ipsilateral endolymphatic sac was observed in 30 of the 40 patients with sudden hearing loss (75%). Twenty of these 30 patients also showed enhancement on the contralateral side, and 1 patient showed enhancement only on the contralateral side. Only 1 of the 5 patients with Meniere's disease showed enhancement. Nine of the 40 control subjects (22.5%) showed enhancement (bilateral enhancement in 5 subjects, unilateral in 4). The frequency of enhancement in patients with sudden hearing loss was significantly higher than that in control subjects ( P<0.0001) or patients with Meniere's disease ( P<0.05). The frequency of contrast enhancement of the endolymphatic sac is significantly increased in patients with sudden hearing loss, but further study is necessary to clarify the relationship between this finding and the pathophysiology of sudden hearing loss.

  702. The role of contrast-enhanced MR mammography for determining candidates for breast conservation surgery. Reviewed

    Zhang Y, Fukatsu H, Naganawa S, Satake H, Sato Y, Ohiwa M, Endo T, Ichihara S, Ishigaki T

    Breast Cancer   Vol. 9 ( 3 ) page: 231-239   2002

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    PURPOSE: The aim of this study was to assess the impact of preoperative magnetic resonance mammography (MRM) on the surgical determination of breast conservation treatment for breast cancer patients. METHODS: From September 1997 to March 2000, 57 consecutive breast conservation treatment candidates were prospectively evaluated with conventional imaging studies (mammography and ultrasonography) and preoperative MRM. RESULTS: In 47 of 54 (87% ) breast cancer patients breast conservation surgery (BCS) was indicated on the basis of mammography (MMG) and ultrasonography (US). However in 40 of the 54 (74% ) patients BCS was indicated on the basis of MRM. Thirty-eight of the 40 patients ultimately underwent BCS and only 1 showed a positive margin. There were 7 patients whose MRM findings suggested that more aggressive treatment than BCS was needed but for whom US/MMG suggested that BCS was appropriate. Five of the 7 patients underwent mastectomy rather than BCS based on the MRM findings, which were justified by post-surgical histological findings. Of the 2 remaining patients who underwent BCS, one had a positive histological margin and one had recurrence, both of which resulted in salvage mastectomy. CONCLUSION: Our study suggests that high resolution preoperative MRM provides more accurate information compared with US and MMG for selecting candidates for BCS. Using MRM as a routine staging tool may reduce unnecessary repeated excisions. A larger study will be required to confirm these findings and to define the patients most likely to benefit from breast MR imaging.

  703. High-spatial-resolution MR cisternography of the cerebellopontine angle in 90 seconds with a zero-fill interpolated fast recovery 3D fast asymmetric spin-echo sequence. Reviewed

    Nakamura T, Naganawa S, Koshikawa T, Fukatsu H, Sakurai Y, Aoki I, Ninomiya A, Ishigaki T

    AJNR Am J Neuroradiol   Vol. 23 ( 8 ) page: 1407-1412   2002

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    BACKGROUND AND PURPOSE: Although the 12-minute 3D fast asymmetric spin-echo (FASE) protocol for imaging the inner ear has been satisfactory, reducing imaging time to minimize patient discomfort and maximize system throughput is desirable. We therefore evaluated the performance of a zero-fill interpolated (ZIP) fast recovery 3D FASE sequence in screening for cerebellopontine (CP) angle lesions in 90 seconds. METHODS: Thirty consecutive patients known or suspected to have CP angle lesions underwent MR imaging at 1.5 T with use of bilateral quadrature phased-array coils designed for examination of the CP angle. Conventional 3D FASE images (4000/240/1 [TR/TE/NEX]) were obtained in 11 minutes 48 seconds with a field of view (FOV) of 16 cm, matrix of 512 x 512 x 40, section thickness of 0.8 mm, and echo train length of 80. Then, ZIP fast recovery 3D FASE images (2000/240/1) were obtained in 90 seconds by using the same FOV. Contrast-enhanced T1-weighted 3D spoiled gradient-echo (SPGR) images were obtained as the reference standard. Three radiologists evaluated the images independently. Conventional 3D FASE and ZIP fast recovery 3D FASE images were reviewed at separate sessions. RESULTS: On 3D SPGR images, 10 tumors were detected in 10 of the 30 patients. All lesions were depicted with both 3D FASE protocols. There were no false-positive results with either 3D FASE protocol. Both protocols showed 100% sensitivity and 100% specificity for all three reviewers. CONCLUSION: High-spatial-resolution MR cisternography with the ZIP fast recovery 3D FASE protocol in 90 seconds results in a substantial reduction (by a factor of about eight) in the time required for screening for CP angle lesions compared with the previously reported conventional 3D FASE protocol, while maintaining high sensitivity and specificity.

  704. Tympanometric findings in patients with enlarged vestibular aqueducts. Reviewed

    Sato E, Nakashima T, Lilly DJ, Fausti SA, Ueda H, Misawa H, Uchida Y, Furuhashi A, Asahi K, Naganawa S

    Laryngoscope   Vol. 112 ( 9 ) page: 1642-1646   2002

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    OBJECTIVES: The purpose of this study was to study systematically some relationships between the resonance frequency of the middle-ear transmission system and the volume of the endolymphatic duct and sac in patients with an enlarged vestibular aqueduct (EVA). STUDY DESIGN: Prospective study. METHODS: Thirteen patients (24 ears) with EVA, 17 subjects (29 ears) with normal hearing, and 17 patients (21 ears) with sensorineural hearing loss without EVA served as experimental subjects. Standard pure-tone audiometry, standard clinical tympanometry (using a 226-Hz probe tone), and multifrequency tympanometry were performed on each ear. Magnetic resonance imaging was used to determine the area of the cochlear modiolus and the volume of the endolymphatic duct and sac. RESULTS: The audiometric configurations for most patients sloped downward from the low to the high frequencies. A significant air-bone gap was computed at each of these test frequencies. Multifrequency tympanometry yielded resonance frequencies for the patients with EVA that was significantly lower than those measured for the control subjects. In general, for patients with EVA, the resonance frequency of the middle ear system decreased as the volume of the endolymphatic duct and sac increased. This inverse relation was significant (correlation coefficient = -0.483, P =.0157). However, there was no correlation between resonance frequency and the degree of cochlea modiolar deficiency. CONCLUSIONS: Clinically, our findings suggest that EVA probably should be included in the differential diagnosis for a patient who presents with a moderate to severe mixed hearing loss, a normal tympanogram at 226 Hz, and a resonance frequency that is abnormally low.

  705. 脳の機能的MRI画像

    長縄慎二

    現代医学   Vol. 49 ( 3 ) page: 363-368   2002

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  706. CT and MR imaging of pancreatic cancer.

    Ishiguchi T, Ota T, Naganawa S, Fukatsu H, Itoh S, Ishigaki T.

    Hepatogastroenterology   Vol. 48 ( 40 ) page: 923-927   2001.7

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    Recent improvements in imaging techniques have made it possible to improve the diagnostic accuracy for detection, staging, and indicating surgical resectability of pancreatic cancer. The latest advance in the computed tomography technique, is the introduction of subsecond multislice helical scanning that improves z-axis resolution in the reformatted images and three-dimensional rendering with a large volume data. Magnetic resonance imaging provides versatile information including magnetic resonance cholangiopancreatography that allows noninvasive delineation of the pancreatic and biliary duct systems. The presence of pancreatic cancer may best be evaluated by dynamic computed tomography or dynamic magnetic resonance imaging with administration of intravenous contrast material. Both computed tomography and magnetic resonance imaging are valuable for the preoperative assessment of local invasion and vascular involvement. Multislice helical computed tomography is currently considered as the best single modality for the diagnosis of pancreatic cancer as it provides excellent image quality. When advanced magnetic resonance imaging equipment is used as a primary modality, in the future, it may have a possibility to replace other imaging modalities.

  707. Phenotypes associated with replacement of His by Arg in the Pendred syndrome gene.

    Sato E, Nakashima T, Miura Y, Furuhashi A, Nakayama A, Mori N, Murakami H, Naganawa S, Tadokoro M

    Eur J Endocrinol   Vol. 145 ( 6 ) page: 697-703   2001

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    BACKGROUND: Pendred syndrome is often associated with inner ear malformations, especially enlarged vestibular aqueduct (EVA). Recently, mutations in the Pendred syndrome gene (PDS) have been reported in patients with EVA, in addition to those with classical Pendred syndrome. OBJECTIVE: The aim of this study was to investigate the genotype-phenotype correlations of PDS. METHODS: Each of the 21 exons and flanking splice regions of PDS was analysed by direct DNA sequencing in nine patients with EVA; allele-specific amplification was performed to confirm the mutation. Genetic analyses were compared with thyroid function tests, perchlorate discharge tests, thyroid volume and pure-tone audiogram. Magnetic resonance imaging was used to determine the volume of the endolymphatic duct and sac of each patient. RESULTS: A missense mutation, H723R, was identified in the homozygous state in three patients and in the heterozygous state in another three. Although none of the patients had goitre, increased serum thyroglobulin and an abnormal degree of iodide release were correlated with the number of mutant alleles identified. However, there was no relationship between the degree of hearing loss and the number of mutant alleles. CONCLUSION: The present study reveals that the number of mutant alleles correlates with the degree of subclinical thyroid abnormality, but not with the degree of hearing loss in Japanese patients with the PDS missense mutation H723R.

  708. Accuracy of plastic replica of aortic aneurysm using 3D-CT data for transluminal stent-grafting: experimental and clinical evaluation. Reviewed

    Kato K, Ishiguchi T, Maruyama K, Naganawa S, Ishigaki T

    J Comput Assist Tomogr   Vol. 25 ( 2 ) page: 300-304   2001

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    PURPOSE: To plan stent-grafting for aortic aneurysms with complicated morphology, we prepared life-sized aortic replicas by laser stereolithography using helical 3D--CT data. The accuracy of the replica was evaluated by measurement of vessel phantoms and clinical 3D--CT data. METHOD: An imaginary aortic wall was created from helical CT images of the aorta, and a hollow plastic replica was produced by laser stereolithography. The accuracy of the replica was evaluated in five abdominal aortic aneurysms by experimental phantom studies and measurements of the replicas. RESULTS: The mean difference in measurements between 3D--CT images and model vessels and between 3D--CT images and aortic replicas was 0.2 mm each. Therefore, the difference in measurements between real aortic aneurysms and the replicas was at most 0.4 mm. CONCLUSION: The accuracy of the replica is satisfactory, making it useful for preoperative evaluation and simulation for stent-grafting.

  709. Virtual endoscopy of the labyrinth, using a 3D-FastASE sequence. Reviewed

    Naganawa S, Iwayama E, Koshikawa T, Fukatsu H, Ishigaki T, Ninomiya A, Aoki I

    J Magn Reson Imaging   Vol. 13 ( 5 ) page: 792-796   2001

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    Virtual endoscopy (VE) of the labyrinth was performed using three-dimensional (3D)-fast asymmetric spin-echo MR imaging. The spatial resolution requirements and the usefulness of zero-fill interpolation (ZIP) were evaluated, and VE was used to examine three patients. The (0.6-mm) voxel data with ZIP satisfies the minimum requirements for VE for evaluation of the complex 3D anatomy and pathology of the labyrinth. J. Magn. Reson. Imaging 2001;13:792-796.

  710. Aortoiliac stenooculusive disease and aneurysms: screening with non-contrast enhanced two-dimensional cardiac gated cine phase contrast MR angiography with multiple velocity encoded values and cardiac gated two-dimensional time-of-flight MR angiography. Reviewed

    Naganawa S, Koshikawa T, Kato K, Ishiguchi T, Ishigaki T, Sato K, Katagiri T, Kishimoto H, Mimura T, Takizawa O, Imura C

    Radiat Med   Vol. 19 ( 2 ) page: 99-105   2001

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    PURPOSE: To evaluate the performance of two-dimensional cine phase contrast MRA with multi-velocity encoded values (multi-VENC cine PC) and ECG-gated two-dimensional time-of-flight MRA (ECG-2D-TOF) for the detection of stenoocclusive lesions and aneurysms in the aortoiliac area, when each method was used individually and when the two methods were used together. METHODS: Forty-one patients were included in this study. Multi-VENC cine PC and ECG-2D-TOF were obtained first, then contrast enhanced three-dimensional magnetic resonance angiography (CE-3D-MRA) was performed as the standard of reference. Two observers reviewed the images separately without knowledge of patients' symptoms or histories. Sensitivities and specificities were obtained separately for stenooclusive lesions and aneurysms by two reviewers. RESULTS: When the two methods were applied together, high sensitivities (93.0 by observer 1 and 91.9% by observer 2) and adequate specificities (87.6 and 82.3%) were obtained for stenoocclusive lesions. For aneurysms, moderate to high sensitivities (91.1 and 71.1%) and high specificities (98.8 and 99.4%) were obtained. CONCLUSION: These results suggest that the performance of two non-contrast enhanced MRA techniques may be valuable as a screening tool when the two methods are applied together.

  711. MR cisternography of the cerebellopontine angle: comparison of three-dimensional fast asymmetrical spin-echo and three-dimensional constructive interference in the steady-state sequences. Reviewed

    Naganawa S, Koshikawa T, Fukatsu H, Ishigaki T, Fukuta T

    AJNR Am J Neuroradiol   Vol. 22 ( 6 ) page: 1179-1185   2001

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    BACKGROUND AND PURPOSE: MR cisternography has been used as the noninvasive screening tool of the cerebellopontine angle. The purpose of this study was to directly compare two currently dominant types of sequences for heavily T2-weighted MR cisternography. METHODS: Three-dimensional fast asymmetric spin-echo (3D-FASE) sequences, which are 3D half-Fourier rapid acquisition with relaxation enhancement and 3D constructive interference in the steady-state (3D-CISS) sequences, were compared on a clinical 1.5-T MR unit using the same scan times. In five healthy volunteers, the contrast-to-noise ratio (C/N) between CSF and the cerebellum was measured at three locations. Then, for qualitative analysis, the quality of the labyrinth was scored on the original source multiplanar reformatted images, the virtual endoscopic images, and the maximum intensity projection (MIP) images. In 20 consecutive patients with suspected cerebellopontine angle tumors, visualization of the tumors was evaluated using 3D contrast-enhanced spoiled gradient-echo imaging as the standard of reference. RESULTS: Both sequences showed comparable mean C/N values; however, in qualitative analysis, the scores for 3D-CISS on the source, virtual endoscopic, and MIP images were significantly lower than those on the images obtained with 3D-FASE, owing to more prominent flow and magnetic susceptibility artifacts on the 3D-CISS sequences. In all subjects, discontinuity of the semicircular canals was seen on the virtual endoscopic and MIP images obtained with 3D-CISS, owing to susceptibility artifacts, but not on those obtained with 3D-FASE. All 12 tumors were detected by both sequences, but 3D-CISS gave one false-positive result. CONCLUSION: 3D-FASE is considered the method of choice because artifacts are reduced and specificity is increased.

  712. Contrast-enhanced MR angiography of the carotid artery using 3D time-resolved imaging of contrast kinetics: comparison with real-time fluoroscopic triggered 3D-elliptical centric view ordering. Reviewed

    Naganawa S, Koshikawa T, Fukatsu H, Sakurai Y, Ichinose N, Ishiguchi T, Ishigaki T

    Radiat Med   Vol. 19 ( 4 ) page: 185-192   2001

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    PURPOSE: To evaluate contrast-enhanced MR angiography using the 3D time-resolved imaging of contrast kinetics technique (3D-TRICKS) by direct comparison with the fluoroscopic triggered 3D-elliptical centric view ordering (3D-ELLIP) technique. METHODS: 3D-TRICKS and 3D-ELLIP were directly compared on a 1.5-Tesla MR unit using the same spatial resolution and matrix. In 3D-TRICKS, the central part of the k-space is updated more frequently than the peripheral part of the k-space, which is divided in the slice-encoding direction. The carotid arteries were imaged using 3D-TRICKS and 3D-ELLIP sequentially in 14 patients. Temporal resolution was 12 sec for 3D-ELLIP and 6 sec for 3D-TRICKS. The signal-to-noise ratio (S/N) of the common carotid artery was measured, and the quality of MIP images was then scored in terms of venous overlap and blurring of vessel contours. RESULTS: No significant difference in mean S/N was seen between the two methods. Significant venous overlap was not seen in any of the patients examined. Moderate blurring of vessel contours was noted on 3D-TRICKS in five patients and on 3D-ELLIP in four patients. Blurring in the slice-encoding direction was slightly more pronounced in 3D-TRICKS. However, qualitative analysis scores showed no significant differences. CONCLUSION: When the spatial resolution of the two methods was identical, the performance of 3D-TRICKS was found to be comparable in static visualization of the carotid arteries with 3D-ELLIP, although blurring in the slice-encoding direction was slightly more pronounced in 3D-TRICKS. 3D-TRICKS is a more robust technique than 3D-ELLIP, because 3D-ELLIP requires operator-dependent fluoroscopic triggering. Furthermore, 3D-TRICKS can achieve higher temporal resolution. For the spatial resolution employed in this study, 3D-TRICKS may be the method of choice.

  713. MR labyrinthographyとMR cisternography

    長縄慎二

    日本医学放射線学会雑誌付録   Vol. 61   page: 2-6   2001

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  714. ECR2001印象記

    長縄慎二

    映像情報メディカル   Vol. 33   page: 516-519   2000.5

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  715. MR imaging of the enlarged endolymphatic duct and sac syndrome by use of a 3D fast asymmetric spin-echo sequence: volume and signal-intensity measurement of the endolymphatic duct and sac and area measurement of the cochlear modiolus. Reviewed

    Naganawa S, Koshikawa T, Iwayama E, Fukatsu H, Ishiguchi T, Ishigaki T, Ikeda M, Nakashima T, Ichinose N

    AJNR Am J Neuroradiol   Vol. 21 ( 9 ) page: 1664-1669   2000

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    BACKGROUND AND PURPOSE: In enlarged endolymphatic duct (EED) and sac (EES) syndrome, deformity of the EED and EES is congenital; however, hearing loss is acquired. To investigate the pathophysiology of progressive sensorineural hearing loss in EED and EES syndrome, we measured the volume of the EED and EES, the diameter of the EED and EES, the area of the cochlear modiolus, and the signal intensity of the EES and compared our findings against degree of hearing loss. METHODS: Thin-section MR images of 33 ears in 17 patients with EED and EES syndrome were studied. All studies were obtained on a 1.5-T MR unit using a quadrature surface phased-array coil. Heavily T2-weighted 3D fast asymmetric spin-echo images were obtained with a voxel size of 0.3 x 0.3 x 0.8 mm without zero-fill interpolation. Two radiologists traced the areas of the EED and EES manually, and the volume was calculated. The area of the cochlear modiolus, diameter of the EED and EES, and signal intensity of the EES were also measured by drawing regions of interest manually. The signal intensity ratio of EES/CSF was calculated. These measured values were compared against audiographic data, and the degree of linear correlation was determined. RESULTS: The volume of the EED and EES, the area of the modiolus, the diameter of the EED and EES, and the signal intensity of the EES did not show significant correlation with degree of hearing loss. CONCLUSION: These findings suggest that there is a microscopic area of damage or fragility in the inner ear not visible even with thin-section heavily T2-weighted MR imaging.

  716. Real-time interactive MR imaging system: sequence optimization, and basic and clinical evaluations. Reviewed

    Naganawa S, Ishiguchi T, Ishigaki T, Sato K, Katagiri T, Kishimoto H, Mimura T, Takizawa O, Imura C

    Radiat Med   Vol. 18 ( 1 ) page: 71-79   2000

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    A real-time interactive MR imaging system (real-time MRI) is an MR scanner which has a fast image updating cycle and the ability to freely change slice orientation, just like an ultrasound imaging system. Recently, such a system has been developed and installed on a clinical 1.5-Tesla system. The purpose of this study was to optimize the pulse sequences for clinical use and to evaluate the clinical usefulness and basic functionality of real-time MRI. For T1-weighted imaging, FLASH (fast low angle shot) can be selected, and up to 5 frames per second can be acquired depending on the matrix size. For T2-weighted imaging, true FISP (fast imaging with steady-state precession) can be selected, and up to 4 frames per second can be acquired. Maximum C/N between liver and spleen was obtained at a flip angle of 20 degrees on FLASH. Maximum C/N between cardiac cavity and wall was obtained at a flip angle of 60 degrees on true FISP. Localization of the right and left coronary arteries could be performed within 30 seconds in three volunteers. Although the present real-time MRI system has drawbacks such as low spatial resolution and relatively low contrast resolution, we expect real-time MRI to be one of the most important tools for future clinical MRI.

  717. Water fat separation using the single acquisition "sandwich" type 3-point Dixon method to optimize knee joint scans. Reviewed

    Shibahara E, Fukatsu H, Naganawa S, Ito T, Iwayama E, Ishigaki T, Segawa T, Zhang W

    Nagoya J Med Sci   Vol. 63 ( 1-2 ) page: 41-49   2000

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    In this paper, we tried to evaluate the effect of water-fat separation on and to optimize the scan condition of the newly developed "Sandwiched" 3-point Dixon method at 0.35 Tesla (T), for knee joint imaging. Using a 0.35T superconductive open magnet system with a solenoid type knee coil, one male and two female normal volunteers (27-37 y.o.) underwent knee joint imaging. Each sequence provided good water-fat separated images. At 0.35T, the gradient echo provided a better contrast than the spin echo. Optimal cartilage-marrow and cartilage-fluid contrast could be obtained at a frip angle (FA) of 90 degrees. There was no significant correlation between cartilage-marrow, cartilage-fluid contrast and repetition time (TR) values within the tested range. Cartilage-fluid and cartilage-marrow contrast were both best at an FA of 90 degrees with the gradient echo sequence. TR from 350 ms to 650 ms did not cause any significant contrast difference in the fat suppressed images. This method is useful and could be the only practical choice for obtaining fat suppressed T1 weighted images for joint magnetic resonance (MR) imaging at 0.35T.

  718. Stent-graft placement for pseudoaneurysm of the aorta. Reviewed

    Maruyama K, Ishiguchi T, Kato K, Naganawa S, Itoh S, Sakurai T, Ishigaki T

    Radiat Med   Vol. 18 ( 3 ) page: 177-185   2000

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    PURPOSE: To evaluate the use of endovascular stent-graft placement to repair pseudoaneurysm of the aorta. METHODS: Six patients were treated with stent-grafts for pseudoaneurysms located in the thoracic aorta (n=2), thoracoabdominal aorta (n=3), and abdominal aorta (n=1). Etiologies of the pseudoaneurysms included leakage from surgical graft, penetrating atherosclerotic ulcer, pneumonia, perforated esophageal ulcer, and mycotic aneurysm. All patients were clinically considered to be at high surgical risk. RESULTS: Stent-grafts were successfully placed in all patients. There was one death in the perioperative period due to massive hemoptysis before stent-grafting. Two patients died of persistent infection. One patient with persistent perigraft leak died of rupture. Two other patients needed no further therapy for pseudoaneurysm. CONCLUSION: Stent-graft placement for pseudoaneurysm of the aorta can play the role of a temporizing method prior to surgical repair in high-risk cases and be a therapeutic alternative in cases without infection or perigraft leakage.

  719. Arachnoid granulations on high-resolution MR images and diffusion-weighted MR images: normal appearance and frequency. Reviewed

    Koshikawa T, Naganawa S, Fukatsu H, Ishiguchi T, Ishigaki T

    Radiat Med   Vol. 18 ( 3 ) page: 187-191   2000

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    Arachnoid granulations (AGs), protrusions into the cerebral venous sinus lumen, have been reported on cerebral venography, contrast enhanced CT, and conventional MR imaging. Although thin-sliced high-resolution MR images and diffusion-weighted images are frequently obtained, there have been no detailed reports concerning AGs on these images. In this study, the frequency and positional distribution of AGs in the transverse sinus was investigated on thin-sliced high-resolution MR images, and their appearance on diffusion-weighted MR images was evaluated. At least one AG was found in 107 of 151 subjects (70.9%). No statistically significant differences were noticed between males and females or between the right and left sides. No significant correlations between age and size or between age and the number of AGs were noted. On diffusion-weighted images, all AGs showed iso-intensity to normal brain tissue, which was higher than the reported signal intensity of arachnoid cyst and lower than that of epidermoids. In conclusion, AGs are normal structures that are frequently found in the cerebral venous sinuses on high-resolution MR images. Knowledge regarding their frequency and normal appearance would be helpful to avoid confusion between pathological processes and AGs. It is also important to know that AGs are frequently found even in the younger population.

  720. Air-bone gap and resonant frequency in large vestibular aqueduct syndrome. Reviewed

    Nakashima T, Ueda H, Furuhashi A, Sato E, Asahi K, Naganawa S, Beppu R

    Am J Otol   Vol. 21 ( 5 ) page: 671-674   2000

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    BACKGROUND: Conductive hearing loss is occasionally recognized in large vestibular aqueduct (LVA) syndrome; however, the incidence rate and the cause are not known. OBJECTIVE: To compare air and bone conduction levels between patients with LVA syndrome and those with idiopathic sudden sensorineural hearing loss, and to investigate the cause of the air-bone gap. STUDY DESIGN: Retrospective study. SETTING: The patients were treated at a tertiary referral center. PATIENTS: Twenty-eight ears of 15 patients with LVA syndrome and 28 ears of patients with idiopathic sudden sensorineural hearing loss were examined. The latter patients were selected from a computerized database to match the former patients in air conduction levels. MAIN OUTCOME MEASURES: Pure-tone audiometry, multiple frequency tympanometry, acoustic reflex, otoacoustic emission, vestibular evoked myogenic response. RESULTS: The air-bone gap in patients with LVA syndrome was always larger than that in patients with idiopathic sudden sensorineural hearing loss with the same air conduction level. The resonant frequency in patients with LVA syndrome was rather low compared with that in normal control subjects, in contrast to the finding that resonant frequency was significantly high in patients with otosclerosis. CONCLUSIONS: An air-bone gap exists to some degree in almost all patients with LVA syndrome. The air-bone gap may not be associated with the movement restriction of the stapes as it is with otosclerosis.

  721. 内耳MRIの現状と展望

    長縄慎二 越川都紀子 深津博 石垣武男

    映像情報メディカル 臨時増刊号 ビジュアルブックシリーズ   Vol. 32   page: 46-52   2000

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  722. MR hydrographyの臨床応用, 耳鼻科領域

    長縄慎二、伊藤都紀子

    画像診断   Vol. 19 ( 7 ) page: 755-763   1999.7

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    耳鼻科領域

  723. MR imaging of the cerebollo pontine argle using a 3D fast spin echo sequence

    Medical Imaging International   Vol. 9 ( 2 ) page: 16-19   1999

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  724. High-resolution MR cisternography of the cerefellopintine angle, of tired in a 0.35-T Open MR unit

    American Journal of Neuro radiology(AJNR)   Vol. 20 ( 6 ) page: 1143-1147   1999

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  725. Fetal sacrococcygesl terotoma visualized by ultrafast T2 Wighted megnetic resonance imaging

    International Journal of gynecology and obstetrics   Vol. 65   page: 191-193   1999

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  726. MR hydrographyの臨床応用耳鼻科銭域

    画像診断   Vol. 19 ( 7 ) page: 755-763   1999

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  727. High-resolution MR images of inner ear internal anatomy using a local gradient coil at 1.5 Tesla: correlation with histological specimen. Reviewed

    Ito T, Naganawa S, Fukatsu H, Ishiguchi T, Ishigaki T, Kobayashi M, Kobayashi K, Ichinose N, Miyazaki M, Kassai Y

    Radiat Med   Vol. 17 ( 5 ) page: 343-347   1999

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    PURPOSE: To obtain high-resolution MR images of the inner ear at 1.5 Tesla with a local gradient coil and to correlate these images with the histological specimen. MATERIALS AND METHODS: All studies were performed on a 1.5 Tesla MR unit with a local gradient coil (23 mT/m, slew rate of 107 mT/m/ms). The cranio-facial region of a cadaver was examined using 3D-fast spin echo (FSE) imaging with the voxel size of 0.27 mm x 0.27 mm x 0.5 mm in 9 h 37 min. Two normal volunteers were examined with the same system using 3D-FSE imaging with the voxel size of 0.20 mm x 0.26 mm x 1.0 mm in 57 min. These images were correlated with the cadaver images and histological specimens. RESULTS: On cadaver images, internal structures such as the macula utriculi, macula sacculi, crista ampullaris, lamina spiralis ossea, ligamentum spirale cochleae, modiolus, scala tympani, scala vestibuli, and cochlear aqueduct were visualized. On the images of both volunteers, the same structures were visualized as on the cadaver images. CONCLUSIONS: This study confirmed that high-resolution MR images obtained at 1.5 Tesla can visualize inner ear internal anatomy. Knowledge obtained in this study may be of significant value for the diagnosis of pathology in the area of the inner ear.

  728. High-resolution MR cisternography of the cerebellopontine angle, obtained with a three-dimensional fast asymmetric spin-echo sequence in a 0.35-T open MR imaging unit. Reviewed

    Naganawa S, Ito T, Iwayama E, Fukatsu H, Ishigaki T

    AJNR Am J Neuroradiol   Vol. 20 ( 6 ) page: 1143-1147   1999

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    High-resolution MR cisternography performed with 3D fast asymmetric spin-echo imaging (3D fast spin-echo with an ultra-long echo train length and asymmetric Fourier imaging) was optimized in a 0.35-T open MR imaging unit. The 0.35- and 1.5-T images of the two volunteers and three patients with acoustic schwannomas were then compared. The optimal parameters for images obtained by 3D fast asymmetric spin-echo imaging at 0.35 T were as follows: field of view, 15 cm; matrix, 256 x 256 x 40; section thickness, 1 mm; echo train length, 76; and imaging time, 10 minutes 44 seconds. Scans obtained from both normal volunteers showed the facial, cochlear, and superior and inferior vestibular nerves separately in the internal auditory canal on both 0.35- and 1.5-T images. All three acoustic schwannomas were depicted on both 0.35- and 1.5-T images. Screening for disease at the cerebellopontine angle and in the internal auditory canal, without the administration of contrast material on a low-field open MR imaging unit and within a clinically acceptable imaging time, may be possible. Further controlled prospective studies are required, however, before implementation on a wide basis. If proved effective, this may be of particular value for reducing healthcare costs and for imaging claustrophobic and pediatric patients in an open system.

  729. Magnitude subtraction vs. complex subtraction in dynamic contrast-enhanced 3D-MR angiography: basic experiments and clinical evaluation. Reviewed

    Naganawa S, Ito T, Iwayama E, Fukatsu H, Ishiguchi T, Ishigaki T, Ichinose N

    J Magn Reson Imaging   Vol. 10 ( 5 ) page: 813-820   1999

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    Magnitude subtraction and complex subtraction in dynamic contrast-enhanced three-dimensional magnetic resonance (3D-MR) angiography were compared using a phantom and 23 human subjects. In phantom studies, complex subtraction showed far better performance than magnitude subtraction, especially for longer echo times, with thicker slices, and without fat suppression. With complex subtraction, non-fat-suppressed studies showed contrast-to-noise ratios comparable to those in fat-suppressed studies. In human subjects, complex subtraction was superior to magnitude subtraction in 9 subjects, but comparable to magnitude subtraction in 14 subjects. There were no cases in which magnitude subtraction was superior to complex subtraction. Although the differences observed in human studies when complex subtraction was applied with thinner slices, shorter echo times, and the fat-suppression technique were not as pronounced as those seen in phantom studies, complex subtraction should be performed in dynamic contrast-enhanced 3D-MR angiography because there are no drawbacks in complex subtraction. Further research is necessary to assess the feasibility of dynamic contrast-enhanced 3D-MR angiography without fat suppression in human subjects using complex subtraction, as suggested by the results of phantom studies. If it is found to be feasible, dynamic contrast-enhanced 3D-MR angiography without fat suppression using complex subtraction may prove to be a robust technique that eliminates the need for shimming and can reduce the acquisition time. J. Magn. Reson. Imaging 1999;10:813-820.

  730. MR imaging of the cochlear modiolus: area measurement in healthy subjects and in patients with a large endolymphatic duct and sac. Reviewed

    Naganawa S, Ito T, Iwayama E, Fukatsu H, Ishigaki T, Nakashima T, Ichinose N

    Radiology   Vol. 213 ( 3 ) page: 819-823   1999

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    PURPOSE: To evaluate the cochlear modiolus with thin-section magnetic resonance (MR) imaging in healthy subjects and patients with a large endolymphatic duct and sac, and to assess whether the cochlea is normal or abnormal in patients with a large endolymphatic duct and sac. MATERIALS AND METHODS: MR images were obtained in 10 ears in five volunteers (group 1), 40 ears in 20 patients with bilateral sensory hearing loss (group 2), three ears in two patients with Mondini malformation (group 3), and 12 ears in seven patients with a large endolymphatic duct and sac (group 4). RESULTS: In groups 1 and 2, all modiolar areas were larger than 4.0 mm2. In group 3, each modiolus was smaller than 2.0 mm2. In group 4, modiolar areas were smaller than 2.0 mm2 in eight ears and were larger than 4.0 mm2 in four ears. CONCLUSION: Findings in this study confirm that a large endolymphatic duct and sac is frequently associated with modiolar deficiency, but the modiolar area is normal in some cases. This result does not support the recently proposed hypothesis that hearing loss with a large endolymphatic duct and sac is caused by the transmission of subarachnoid pressure forces into the labyrinth through a deficient modiolus.

  731. Fetal sacrococcygeal teratoma visualized by ultra-fast T2 weighted magnetic resonance imaging. Reviewed

    Okamura M, Kurauchi O, Itakura A, Naganawa S, Watanabe Y, Mizutani S

    Int J Gynaecol Obstet   Vol. 65 ( 2 ) page: 191-193   1999

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    We report here a fetal sacrococcygeal teratoma found at 26 weeks of gestation. An ultra-fast T2 weighted imaging method enables the clear visualization of morphological details of the fetus without motion artifacts. Complete surgical resection was performed immediately after cesarean birth, and no evidence of tumor recurrence was confirmed at 1 year of age.

  732. High-resolution MR cisternography of the cerebellopontine angle: 2D versus 3D fast spin-echo sequences. Reviewed

    Iwayama E, Naganawa S, Ito T, Fukatsu H, Ikeda M, Ishigaki T, Ichinose N

    AJNR Am J Neuroradiol   Vol. 20 ( 5 ) page: 889-895   1999

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  733. Clinical evaluation of three-dimensional MR-cholangiopancreatography using three-dimensional Fourier transform fast asymmetric spin echo method (3DFT-FASE): usefulness of observation by multi-planar reconstruction. Reviewed

    Yamakawa K, Naganawa S, Maruyama K, Kato T, Fukatsu H, Ishigaki T

    Radiat Med   Vol. 17 ( 1 ) page: 15-19   1999

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    MR-cholangiopancreatography (MRCP) is a new method that is non-invasive and permits volume data collection and three-dimensional expression. With the three-dimensional Fourier transform fast asymmetric spin echo (3DFT-FASE) method, a higher spatial resolution can be obtained both in-pain and in slice selecting direction. In this paper, the usefulness of this new technique is investigated in the clinical diagnosis of MIP images and MPR. The study was performed in 10 normal volunteers and 21 patients with abnormalities in the pancreas or bile-duct sustem. The study was done using a 1.5 Tesla super-conductive machine. The MRCP images were interpreted by three radiologists. In most cases good images were obtained. The additional clinical information provided by MPR was remarkably useful in cystic lesions, especially in mucinous cystic neoplasm of the pancreas. Even when the intestine overlapped the pancreas, it was possible to evaluate the pancreatic duct by MPR. Three-dimensional observation and clinically useful diagnosis were possible by utilizing the advantageds of the 3DFT-FASE method appears quite useful in clinical application.

  734. MR cisternography of the cerebellopontine angle using a 3D fast spin echo sequence

    Naganawa S, Ito T, Iwayama E, Fukatsu F, Ishigaki T

    Medical Imaging International   Vol. 9   page: 16-18   1999

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  735. Three-dimensional Fast spin echo MR of inner ear

    American Journal of Neuroradiology   Vol. 19   page: 739-741   1998

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  736. Inter observer agreement in sonographic diagnosis of breast tumors

    European Journal of ultrasound   Vol. 8   page: 25-31   1998

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  737. MR imaging of the inner ear

    Radiology   Vol. 208   page: 679-685   1998

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  738. Interobserver agreement in sonographic diagnosis of breast tumors. Reviewed

    Shimamoto K, Sawaki A, Ikede M, Satake H, Naganawa S, Tadokoro M, Isomura T, Hirota H, Ishigaki T

    Eur J Ultrasound   Vol. 8 ( 1 ) page: 25-31   1998

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    OBJECTIVE: To evaluate interobserver agreement in the interpretation of breast ultrasonography. METHODS: 55 breast masses (30 benign, 24 malignant) were interpreted by seven radiologists using a CRT viewing station. US criteria for differentiating between benign and malignant lesions included shape, border, boundary echoes, internal echoes, posterior echoes, and bilateral shadows. Each criterion and the observers' final impression was scored using the 5-point rating scales. For analyzing interobserver agreement, the kappa (kappa) values were employed. RESULTS: The kappa values of shape and posterior echoes were significantly higher than those of the other four criteria (P<0.05). Agreement was intermediate in border and internal echoes, and was low in boundary echoes and bilateral shadows. Agreement in the senior group (four observers) was relatively higher than that in the junior group (three observers) for all criteria but for internal echoes. Easily-diagnosed cases showed significantly higher kappa values compared with more ambiguous cases (P<0.05). CONCLUSION: Interobserver agreement in shape and posterior echoes was significantly higher than those of the other four criteria. Agreement was significantly dependent on case difficulty.Copyright 1998 Elsevier Science Ireland Ltd.

  739. フェリデックス投与後のT1強調像が評価に有用であった2例

    深津博、長縄慎二 岩山恵理子、石垣武男

    映像情報メディカル   Vol. 30   page: 1030-1032   1998

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  740. 分岐型ステントグラフトを留置した腹部大動脈瘤の1例

    岩井宏悦、石口恒男、鈴木耕次郎、新畑昌滋、長縄慎二、丸山邦弘、石垣武男、小林英昭、松下昌裕、櫻井恒久

    映像情報メディカル   Vol. 30   page: 753-755   1998

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  741. Three-dimensional fast spin-echo MR of the inner ear: ultra-long echo train length and half-Fourier technique.

    Naganawa S, Itoh T, Fukatsu H, Ishigaki T, Nakashima T, Kassai Y, Miyazaki M, Takai H

    AJNR Am J Neuroradiol   Vol. 19 ( 4 ) page: 739-741   1998

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    We compared the image quality of the newly developed ultra-long echo train length (ETL) 3-D fast spin-echo (FSE) and half-Fourier technique, which is performed in less than 3 minutes, with the conventional 3D-FSE imaging technique, which takes 15 minutes, in assessing MR examinations of the inner ear. The new method's images were almost comparable to the conventional 3D-FSE images in depicting anatomic details and pathologic findings. Implementation of the ultra-long ETL and half-Fourier 3D-FSE imaging technique enables acquisition of inner ear MR studies in a vastly reduced time and with high spatial resolution without significant penalty, opening the possibility for low-cost screening of acoustic tumors without contrast enhancement in less than 3 minutes.

  742. Screening helical CT for mass screening of lung cancer: application of low-dose and single-breath-hold scanning. Reviewed

    Itoh S, Ikeda M, Isomura T, Endo T, Yamakawa K, Itoh K, Naganawa S, Maruyama K, Ishigaki T

    Radiat Med   Vol. 16 ( 2 ) page: 75-83   1998

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    PURPOSE: To investigate the usefulness of helical CT with low-dose and single-breath-hold scanning for lung cancer screening. MATERIALS AND METHODS: Twenty-four helical CT scans of the lung were performed using various parameters in 10 healthy volunteers. The effects of tube current and pitch were evaluated by assessment of image quality and detection of simulated nodules. Screening helical CT was performed at 120 kVp, 50 mA, 1 sec/rotation, 10 mm collimation, and a pitch of 2.0 in 110 patients. The ability of this method to detect nodules and masses, focal parenchymal opacities, and diffuse fibrotic changes was evaluated using conventional CT as the gold standard. RESULTS: A reduction in tube current to 50 mA did not significantly change the assessment of image quality or detection of simulated nodules. Although these factors were degraded by increasing the pitch, there was no significant difference between 1.5 and 2.0. Screening helical CT permitted the entire lung to be scanned with ease during a single-breath-hold in all patients. This method detected 177 of 196 nodules and masses (87 of 91 lesions greater than 5 mm in diameter), 54 of 57 focal parenchymal opacities, and 15 of 15 cases with fibrotic changes. CONCLUSION: Screening helical CT with low-dose and single-breath-hold scanning shows promise for lung cancer screening.

  743. MR imaging of the inner ear: comparison of a three-dimensional fast spin-echo sequence with use of a dedicated quadrature-surface coil with a gadolinium-enhanced spoiled gradient-recalled sequence. Reviewed

    Naganawa S, Ito T, Fukatsu H, Ishigaki T, Nakashima T, Ichinose N, Kassai Y, Miyazaki M

    Radiology   Vol. 208 ( 3 ) page: 679-685   1998

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    PURPOSE: To prospectively evaluate the sensitivity and specificity of magnetic resonance (MR) imaging in the inner ear with a long echo train, three-dimensional (3D), asymmetric Fourier-transform, fast spin-echo (SE) sequence with use of a dedicated quadrature-surface phased-array coil to detect vestibular schwannoma in the cerebellopontine angle and the internal auditory canal. MATERIALS AND METHODS: In 205 patients (410 ears) with ear symptoms, 1.5-T MR imaging was performed with unenhanced 3D asymmetric fast SE and gadolinium-enhanced 3D gradient-recalled (SPGR) sequences with use of a quadrature surface phased-array coil. The 3D asymmetric fast SE images were reviewed by two radiologists, with the gadolinium-enhanced 3D SPGR images used as the standard of reference. RESULTS: Nineteen lesions were detected in the 410 ears (diameter range, 2-30 mm; mean, 10.5 mm +/- 6.4 [standard deviation]; five lesions were smaller than 5 mm). With 3D asymmetric fast SE, sensitivity, specificity, and accuracy, respectively, were 100%, 99.5%, and 99.5% for observer 1 and 100%, 99.7%, and 99.8% for observer 2. CONCLUSION: The unenhanced 3D asymmetric fast SE sequence with a quadrature-surface phased-array coli allows the reliable detection of vestibular schwannoma in the cerebellopontine angle and internal auditory canal.

  744. 3D-fast spin echo法を用いた小脳橋角部のMR cisternography

    映像情報メディカル   Vol. 29 ( 6 ) page: 341-343   1997

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  745. Cerebral black blood MR angiography with the interleaved multi-slab three-dimensional fast spin echo sequence. Reviewed

    Naganawa S, Ito T, Shimada H, Nagao R, Endo T, Uchiumi K, Ishigaki T

    Radiat Med   Vol. 15 ( 6 ) page: 385-388   1997

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    To overcome the disadvantages of conventional three-dimensional time-of-flight MR angiography (3D-TOF), such as saturation or intravoxel dephasing, black blood MR angiography (BB-MRA) using an interleaved multi-slab 3D fast spin echo sequence was developed and evaluated clinically. In major branches, the contrast-to-noise ratio of the flow was not as good as 3D-TOF in BB-MRA. However, in-plane slow flow and large aneurysm were visualized better on BB-MRA than on 3D-TOF. Furthermore, BB-MRA could provide wider coverage than 3D-TOF. BB-MRA using interleaved multi-slab 3D fast spin echo is now feasible and complementary to 3D-TOF.

  746. 著明な心、肺血管内進展を示した肺門部腫瘍の1例

    河津省司、伊藤都紀子、加藤加代子、稲垣弘、長縄慎二、丸山邦弘、深津博、石口恒男、小林英敏、石垣武男、碓氷章彦、吉田光伸

    映像情報メディカル   Vol. 29   page: 1542-1545   1997

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  747. High speed and high resolution MR imaging og the inner ear asinng ultra-long echo train length 3D fast spin echo sequence and half Eonrier imaging

    Proceedings of ISMRM     page: 631   1996

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  748. MR imaging of the primary breast lymphoma

    Breast Cancer   Vol. 3 ( 3 ) page: 209-213   1996

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  749. 従来型CT装置における造形剤投与法の腹部域での検討

    映像情報メディカル   Vol. 28 ( 3 ) page: 332-335   1996

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  750. High resolution T2 weighted MR imaging of the inner ear using a long echo train length 3D fast spin echo sequence

    European Radiology   ( 6 ) page: 369-374   1996

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  751. MR lmaging of the Primary Breast Lymphoma: A Case Report. Reviewed

    Naganawa S, Endo T, Aoyama H, Ichihara S

    Breast Cancer   Vol. 3 ( 3 ) page: 209-213   1996

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    Recently magnetic resonance (MR) imaging has been investigated for the detection and differentiation of benign and malignant breast lesions. Dynamic scan using the contrast material has been shown to increase the specificity of breast MR imaging. Primary breast lymphoma (PBL) is a rare disease and its MR imaging finding has not been described before. We recently experienced a case of PBL that was demonstrated on MR imaging as an early enhancing mass similar to common carcinomas. Other imaging findings including sonography, mammography were also non-specific. Furthermore, lymphoma cells had spread beyond the early enhanced area. Thus the precise delineation of the tumor extent was impossible. However, features such as a quite unclear border on pre-contrast T2-weighted image, and increased uptake of gallium-67-citrate may allow diagnosis of such lesions as malignant lymphoma.

  752. 副乳腺に発生した乳癌の一例.

    林崎理子、遠藤登喜子、長縄慎二、青山英昭、関谷正徳、長田和久、市原周.

    映像情報メディカル   Vol. 28   page: 735-738   1996

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  753. High-resolution T2-weighted MR imaging of the inner ear using a long echo-train-length 3D fast spin-echo sequence.

    Naganawa S, Yamakawa K, Fukatsu H, Ishigaki T, Nakashima T, Sugimoto H, Aoki I, Miyazaki M, Takai H

    Eur Radiol   Vol. 6 ( 3 ) page: 369-374   1996

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    The purpose of this study was to assess the value of a long echo-train-length 3D fast spin-echo (3D-FSE) sequence in visualizing the inner ear structures. Ten normal ears and 50 patient ears were imaged on a 1.5T MR unit using a head coil. Axial high-resolution T2-weighted images of the inner ear and the internal auditory canal (IAC) were obtained in 15 min. In normal ears the reliability of the visualization for the inner ear structures was evaluated on original images and the targeted maximum intensity projection (MIP) images of the labyrinth. In ten normal ears, 3D surface display (3D) images were also created and compared with MIP images. On the original images the cochlear aqueduct, the vessels in the vicinity of the IAC, and more than three branches of the cranial nerves were visualized in the IAC in all the ears. The visibility of the endolympathic duct was 80%. On the MIP images the visibility of the three semicircular canals, anterior and posterior ampulla, and of more than two turns of the cochlea was 100%. The MIP images and 3D images were almost comparable. The visibility of the endolymphatic duct was 80% in normal ears and 0% in the affected ears of the patients with Meniere's disease (p < 0.01). In one patient ear a small intracanalicular tumor was depicted clearly. In conclusion, the long echo train length T2-weighted 3D-FSE sequence enables the detailed visualization of the tiny structures of the inner ear and the IAC within a clinically acceptable scan time. Furthermore, obtaining a high contrast between the soft/bony tissue and the cerebrospinal/endolymph/ perilymph fluid would be of significant value in the diagnosis of the pathologic conditions around the labyrinth and the IAC.

  754. High resolution T-2 weighted image of the inner ear with 3D-Fast Spin echo sequence

    European Radiology   Vol. 5 ( Suppl ) page: 366   1995

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  755. High resolution MR imaging of the inner ear using 3D-ESE

    Nippon Acta Radiologica   Vol. 55 ( 1 ) page: 81-82   1995

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  756. Internal anotomy of the inner ear at MR imaging with a Long-Echo-Train-Length 3D,Fast SE sequence

    Radiology   Vol. 197 ( 9 ) page: 134-135   1995

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  757. Visualization of the internal anatomy of the inner ear using a long echo train length 3D fast spin echo sequence

    Proceedings of SMR     page: 230   1995

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  758. Inner ear barotrauma: computed tomographic evaluation. Reviewed

    Nakashima T, Yanagita N, Yamakawa K, Naganawa S

    Clin Otolaryngol Allied Sci   Vol. 20 ( 6 ) page: 544-546   1995

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    Eight patients with inner ear barotrauma were evaluated by computed tomography. The causes of the inner ear barotrauma were diving in four, flying in an airplane in three, and climbing in one. Regarding the width of the cochlear aqueduct, no significant difference was observed between the affected side (3.28 +/- 0.49 mm) and non-affected side (3.63 +/- 0.79 mm) at the base of the infundibulum. The jugular fossa could not be identified on the affected side in three patients. Some relationship may exist between inner ear barotrauma and poor development of the jugular fossa.

  759. High resolution MR imaging of the inner ear apparatus using 3D-Fast spin echo sequence Reviewed

    Naganawa S, Senda K, Yamakawa K, Fukatsu H, Ishigaki T, Nakashima T, Sugimoto H, Aoki I, Takai H

    Nippon Igaku Hoshasen Gakkai Zasshi   Vol. 55 ( 1 ) page: 81-82   1995

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    To evaluate the efficacy of high resolution MR imaging of the inner ear with 3D-Fast spin echo sequence, one volunteer and 12 patients were imaged with a 1.5 T MR scanner. High resolution T2-weighted images were obtained with a head coil in 13 minutes, and the voxel size was 0.39mm x 0.45mm x 1.2mm in most subjects. Original images and maximum intensity projection (MIP) images of the inner ear were evaluated. On original images, the endolymphatic duct was visualized in 72% of subjects, the cochlear aqueduct in 96%, three branches of the cranial nerves in the internal auditory canal in 100%, and flow void of the vessel in the cerebellopontine angle in 100%. On MIP images, more than two cochlear turns were visualized in 92% of subjects, three semicircular canals in 100%, and the anterior and posterior ampulla in 100%. MR imaging of the inner ear with 3D-Fast Spin Echo sequence provides a variety of useful information regarding the anatomy around the inner ear.

  760. Flow velocity and volume measurement of superior and interior mesenteric artery with cine phase contrast magnetic resonance imaging

    Radiation Medicine   Vol. 12 ( 5 ) page: 213-220   1994

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  761. Rapid MR imaging of the liver

    Radiation Medicine   Vol. 12 ( 6 ) page: 255-261   1994

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  762. Magnetic Resonance imaging of the endolymphotic duct and sae in Meniere's disease

    Auris-Nasus-Larynx   Vol. 19 ( supl. ) page: 81-87   1992

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  763. MRI of the vestibular aquaduct

    Nippon Acta Radiologica   Vol. 51 ( 3 ) page: 213-218   1991

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  764. Evaluation of clearance function of the Eustachian tube by sequential contrast CT. Reviewed

    Niwa H, Takahashi M, Yanagita N, Naganawa S

    Acta Otolaryngol Suppl   Vol. 471   page: 43-50   1990

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    Comparisons of Eustachian tube (ET) functions studied by sequential contrast computerized tomography (CT) and by tubotympanic aerodynamics (TTAG) were made. ET clearance function was assessed by the shape of the cartilaginous portion before, during and at the end of swallowing; ventilatory function was studied by TTAG. ET clarity, real-time dynamics and resolution were all better when observed with sequential CT. Contrast medium was instilled into the middle ear via a drumhead perforation and 1 scan/sec taken during swallowing. We classified ET function based on the presence or absence of a) movement of the cartilaginous portion, and b) contrast medium in the ET as i) movement present, contrast medium seen in ET: ii) movement absent, contrast medium present in ET; and iii) movement present, no contrast medium in the ET. Ventilatory and clearance functions did not parallel one another, attributable to some mechanical, differences between the two functions.

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Books 29

  1. Towards a Better Understanding of the Pathophysiology and Clinical Management of Idiopathic Normal Pressure Hydrocephalus. Reviewed International journal

    In Karagiozov, K.L., Leinonen, V., Miyajima M, Nakajima M. Naganawa S eds.

    Lausanne: Frontiers Media SA.  2022.10 

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    Language:English

  2. Hydropic Ear Disease: Imaging and Functional Evaluation Reviewed International journal

    Gurkov, R., Naganawa Shinji, Pyykko, I., eds.( Role: Joint author)

    Lausanne: Frontiers Media SA.  2022.5 

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    Language:English

  3. 【2010年】MRI座談会 (スウェーデン・ストックホルム) さらなる進化をとげた拡散強調画像、そして7Tの今後の行方 Reviewed

    押尾亮一、長縄慎二、高原太郎、青木隆敏、他(119−137)

    産業開発機構株式会社  2018.9 

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    Responsible for pages:119−137   Language:Japanese

  4. まるわかり 頭頸部領域の画像診断 【第1章 聴覚・平衡感覚 5.めまい】

    豊田圭子、小玉隆男、矢野貴徳、長縄慎二、大原有紗、外山芳弘、土屋一洋、木村成秀、德丸阿耶、朝日公一、青木茂樹、櫻井圭太、村山繁雄、森 暢幸、柳町徳春、森 墾、中井雄大、大場 洋、桂 正樹、佐藤典子、中里龍彦、前田正幸、海野真記、早川克己、加藤博基、山本麻子、齋藤尚子、治山高弘、泉澤 充、神田知紀、北村弘樹、本城尚美、東海林 理、森 典子、丹羽 徹、相田典子、安藤久美子、石川祐一、松島信佳、市場文功、佐藤雅史、田中法瑞、吉田大介、二階堂 孝 ( Role: Joint author)

    秀潤社  2015.9 

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  5. 頭頸部画像診断に必要不可欠な臨床・画像解剖

    藤田晃史、酒井 修、杉本英治、豊田圭子、石川牧子、塚本 浩、森 墾、浮洲龍太郎、小玉隆男、長縄慎二、( Role: Joint author)

    秀潤社  2015.4 

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  6. 画像診断、頭蓋底-disease oriented anatomy-

    長縄慎二( Role: Joint author)

    秀潤社  2013 

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  7. MRI 応用自在 第3版 拡散強調画像 Readout segmented EPI(RESOLVE)

    長縄慎二( Role: Joint author)

    メジカルビュー社  2013 

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  8. MRI 応用自在 第3版、Hydeography MR cisternography, MR myelography

    長縄慎二( Role: Joint author)

    メジカルビュー社  2013 

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  9. これでわかる拡散MRI 第3版・びまん性軸索損傷患者における拡散テンソルtractography

    長縄慎二( Role: Sole author)

    秀潤社  2013 

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    Language:Japanese

  10. これでわかる拡散MRI 第3版・高磁場MRの拡散への応用:磁場強度と拡散

    長縄慎二( Role: Sole author)

    秀潤社  2013 

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  11. 中内耳-CT・MRI解剖アトラス-

    長縄慎二( Role: Sole author)

    中外医学社  2012.4 

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  12. 頭頸部のCT・MRI 第2版

    長縄慎二( Role: Joint author)

    メディカルサイエンスインターナショナル  2012.3 

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  13. 脳神経外科エキスパート 頭蓋底

    長縄慎二( Role: Sole author)

    中外医学社  2009.9 

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  14. 臨床研修プラクティス4(7)

    鈴木耕次郎、長縄慎二( Role: Joint author)

    文光堂  2007.7 

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  15. カンファランス形式頭部画像診断演習~8.機能的疾患編著:土屋一洋

    長縄慎二( Role: Sole author)

    秀潤社  2006.9 

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  16. 『脳神経外科学大系第2巻 検査・診断法』著者:山浦 晶、吉田 純

    長縄慎二( Role: Sole author)

    中山書店  2006.4 

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    3章 画像診断 CT

  17. 『新版 これでわかる拡散』 青木茂樹 編

    長縄慎二( Role: Sole author)

    秀潤社  2005.10 

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    3T-MRI

  18. 『3T-MRI装置の臨床的利点について』

    長縄慎二( Role: Sole author)

    日本磁気共鳴医学会 安全性評価委員会  2005 

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    MRの最近の進歩と安全性

  19. 『MRI応用自在 改訂版』 監修 蜂屋 順一  編集 高原 太郎扇 和之

    長縄慎二( Role: Sole author)

    メジカルビュー社  2004.9 

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    【臨床応用】 I Hydrography
     7 MR cisternography,MR myelography

  20. 『頭頸部の画像診断』編著:酒井 修

    長縄慎二( Role: Sole author)

    秀潤社  2002.8 

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    1. 側頭骨(中耳・内耳・脳神経)

  21. 『頭頸部のCT・MRI』 多田信平 黒崎喜久 編集

    長縄慎二( Role: Sole author)

    メディカルサイエンスインターナショナル  2002 

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    側頭骨の奇形  小脳橋角部と感音性難聴

  22. 『現場で役立つ臨床MRIシリーズ 2~MR hydrographyとMR angiography~水と流れの画像』杉村和朗 監修

    長縄慎二( Role: Sole author)

    メジカルビュー社  1999.11 

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    頭頸部疾患  
    主要撮像法/正常解剖/症例

  23. 『画像診断のための解剖図譜 9』改訂第3版

    長縄慎二、伊藤都紀子( Role: Joint author)

    メジカルビュ−社  1999.6 

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    MR. CTからみた肩関節の解剖、
    MR. CTからみた肘関節の解剖、
    MR. CTからみた手関節の解剖

  24. 『臨床放射線科のコツと落とし穴 2 検査・診断 part2』 小塚 隆弘 編

    長縄慎二( Role: Sole author)

    中山書店  1999.5 

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    MRAのMIPなどの画像処理の特徴と落とし穴

  25. 『臨床放射線科のコツと落とし穴 1 検査・診断 part1』小塚 隆弘 編

    長縄慎二( Role: Sole author)

    中山書店  1999.4 

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    高分解能MRIを用いた聴神経腫瘍の診断のコツと落とし穴

  26. 『Excerpta Medica, International Congress Series 1192, Radiology: Ultrafast magnetic resonance in medicine』 Shouji Naruse, Hiroshi Watari, editors.

    S. Naganawa, T. Ito, E. Iwayama, H. Fukatsu, T. Ishigaki, and N. Ichinose.( Role: Joint author)

    Elsevier Science B. V.  1999 

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    Comparison between Magnitude Subtraction vs Complex Subtraction in Dynamic Contrast Enhanced 3D-MR Angiography: Basic Experiments and Clinical Application.

  27. 『耳と脳幹 脳神経の最新MRI』熊川孝三、煎本正博 編

    中島務、鈴木亨、柳田則之、長縄慎二( Role: Joint author)

    メジカルビュ−社  1991.6 

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    メニエール病、遅発性内リンパ水腫における前庭水管のMRI

  28. 『耳鼻咽喉領域疾患』

    佐久間貞行、長縄慎二.( Role: Joint author)

    東芝メディカル  1989 

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    X線CT像の診かた(教育用VTR)

  29. 『Annual Review ~消化器 1988~』

    山川耕二、丸山邦弘、広瀬光彦、長縄慎二( Role: Joint author)

    中外医学社  1988 

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    膵胆の画像診断

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MISC 97

  1. ALPS-indexを用いた糖尿病と糖尿病前期の病態におけるGlymphatic systemの評価 Reviewed

    Tuerxun Rukeye, 鎌形 康司, Andica Christina, 内田 航, 斎藤 勇哉, 高林 海斗, 加賀 英義, 染谷 由希, 明石 敏昭, 和田 昭彦, 田端 宏樹, 内藤 仁嗣, 田村 好史, 田岡 俊昭, 長縄 慎二, 河盛 隆造, 綿田 裕孝, 青木 茂樹

    日本磁気共鳴医学会雑誌   Vol. 43 ( 2 ) page: 60 - 62   2023.5

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    Language:Japanese   Publisher:(一社)日本磁気共鳴医学会  

  2. 脳内リンパ系(Glymphatic system)の非侵襲的評価方法:硬膜下血腫症例でのDiffusion Weighted Image Analysis Along the Perivascular Space(DWI-ALPS)法による脳間質液動態評価の試み Reviewed

    田岡俊昭, 田岡俊昭, 伊藤倫太郎, 伊藤倫太郎, 中道玲瑛, 長縄慎二

    日本宇宙航空環境医学会大会プログラム抄録集   Vol. 69th (CD-ROM)   2023

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  3. SMART-ALPS法による間質液動態の高時間分解能での評価 Reviewed

    田岡俊昭, 伊藤倫太郎, 中道玲瑛, 中根俊樹, 酒井黛呼, 長縄慎二

    日本神経放射線学会プログラム・抄録集   Vol. 52nd   2023

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  4. ALPS-indexを用いた糖尿病と糖尿病前期の病態におけるGlymphatic systemの評価[大会長賞記録] Reviewed

    Tuerxun Rukeye, 鎌形康司, Andica Christina, 内田航, 斎藤勇哉, 高林海斗, 加賀英義, 染谷由希, 明石敏昭, 和田昭彦, 田端宏樹, 内藤仁嗣, 田村好史, 田村好史, 田岡俊昭, 長縄慎二, 河盛隆造, 河盛隆造, 綿田裕孝, 綿田裕孝, 青木茂樹

    日本磁気共鳴医学会雑誌(Web)   Vol. 43 ( 2 )   2023

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  5. 人工知能を応用したバーチャル3D thin-section CTを用いた肺腺癌の充実成分径の計測 Reviewed

    岩野信吾, 神谷晋一朗, 伊藤倫太郎, 工藤彰, 北村嘉郎, 中村圭児, 長縄慎二

    断層映像研究会雑誌(Web)   Vol. 49 ( 2 )   2022

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  6. Does the Pulsatile Non-uniform Flow Matter in MR Flowmetry? Reviewed

    Masataka Sugiyama, Yasuo Takehara, Shinji Naganawa

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 21 ( 2 ) page: 365 - 371   2022

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    3D cine phase-contrast (4D flow) MRI is a sequence with great potential for non-invasive time-resolved 3D flowmetry at arbitrary vessel sections in various blood vessels. However, it is not widely known that the flowmetry with 4D flow MRI is vulnerable to pulsatile and non-uniform flow. Due to the limited spatial and temporal resolutions, averaging within the 3D voxel is occurring during the flowmetry. A simple solution is to avoid setting the measurement plane in the area where non-uniform flow is dominant, which is possible with an aid of streamline depictions generated by computational fluid dynamics (CFD) or 4D flow MRI data. Unlike 4D flow MRI, flowmetry in CFD simulation can use higher spatial and temporal resolution depending on computer performance; therefore, it is robust to fluctuating non-uniform flow. However, the performance of CFD simulations might be limited due to inlet conditions with low temporal resolution. Difficulty applying complex blood flow such as reflection flow from periphery may also limit accurate simulation. Caution should be taken when comparing the result of CFD simulation to that of 4D flow measurement.

    DOI: 10.2463/mrms.rev.2021-0099

    Web of Science

  7. 硬膜下血腫例でのDiffusion Weighted Image Analysis Along the Perivascular Space(DWI-ALPS)の応用 Reviewed

    田岡俊昭, 伊藤倫太郎, 中道玲瑛, 中根俊樹, 市川和茂, 酒井黛呼, 長縄慎二

    日本神経放射線学会プログラム・抄録集   Vol. 51st   2022

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  8. 鼻腔glomangiopericytomaの2症例 Reviewed

    阿部考志, 伊藤倫太郎, 中道玲瑛, 阿部有美, 川井恒, 田岡俊昭, 佐竹弘子, 長縄慎二

    Japanese Journal of Radiology   Vol. 40 ( Supplement )   2022

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  9. 拡散MRIによるグリンパティックシステム機能指標と脳脊髄液Aβ及び脳糖代謝能との関連 Reviewed

    鎌形康司, 高林海斗, 斎藤勇哉, 田岡俊昭, 野崎隼杜, アンディカ クリスティナ, 和田昭彦, 明石敏昭, 菊田潤子, 長縄慎二, 青木茂樹

    日本神経放射線学会プログラム・抄録集   Vol. 51st   2022

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  10. ALPS methodを用いた高血圧症における血管周囲腔方向の拡散能変化の検討 Reviewed

    菊田潤子, 鎌形康司, 高林海斗, 染谷由希, 田村好史, 河盛隆造, 綿田裕孝, 田岡俊昭, 長縄慎二, 青木茂樹

    日本神経放射線学会プログラム・抄録集   Vol. 50th   2021

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  11. COVID-19 肺炎におけるAI研究の動向および問題点について Reviewed

    伊藤倫太郎, 伊藤倫太郎, 岩野信吾, 岩野信吾, 長縄慎二, 長縄慎二

    医用画像情報学会雑誌(Web)   Vol. 38 ( 2 )   2021

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    J-GLOBAL

  12. 人工知能による胸部単純写真からの肺野画像の生成 Reviewed

    伊藤倫太郎, 岩野慎吾, 長縄慎二

    日本医学放射線学会秋季臨床大会抄録集   Vol. 57th   2021

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  13. The artificial intelligence for COVID-19 pneumonia. Reviewed

    月刊臨床免疫・アレルギー科   Vol. 75 ( 2 )   2021

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  14. Water Peak MRS:組織中の溶媒の評価の試み Reviewed

    田岡俊昭, 伊藤倫太郎, 阿部考志, 中道玲瑛, 中根俊樹, 川井恒, 長縄慎二

    日本神経放射線学会プログラム・抄録集   Vol. 50th   2021

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  15. Multi b-value Diffusion weighted image Diphase Map(MbDDM)による脳脊髄液動態の評価 Reviewed

    田岡俊昭, 田岡俊昭, 伊藤倫太郎, 伊藤倫太郎, 中道玲瑛, 中根俊樹, 川井恒, 長縄慎二

    日本神経放射線学会プログラム・抄録集   Vol. 49th   2020

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  16. Size Measurements of Lung Cancer Using 3D-CT and PET/CT Reviewed

      Vol. 40 ( 5 ) page: 439 - 446   2020

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  17. TNM分類(UICC8版)に基づいた臨床病期I期肺癌の予後評価 Reviewed

    岩野信吾, 馬越弘泰, 神谷晋一朗, 島本宏矩, 伊藤倫太郎, 長縄慎二

    Japanese Journal of Radiology   Vol. 38 ( Supplement )   2020

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  18. 正常老化におけるTHK5351分布様式と安静時機能的ネットワークの関係性 Reviewed

    吉田 有佑, 横井 孝政, 渡辺 宏久, 山口 博司, Bagarinao Epifanio, 桝田 道人, 加藤 隼康, 小倉 礼, 大嶽 れい子, 川畑 和也, 原 一洋, 勝野 雅央, 加藤 克彦, 長縄 慎二, 岡村 信行, 矢内 一彦, 祖父江 元

    臨床神経学   Vol. 59 ( Suppl. ) page: S297 - S297   2019.11

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  19. 血管炎と脳卒中 もやもや病類縁疾患の頭蓋内血管狭窄進行予測 Reviewed

    村岡 真輔, 荒木 芳生, 岡本 奨, 田岡 俊昭, 川井 恒, 宇田 憲司, 太田 慎次, 長縄 慎二, 若林 俊彦

    The Mt. Fuji Workshop on CVD   Vol. 37   page: 70 - 75   2019.7

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    もやもや病および類もやもや病24例48半球を対象に、年齢、発症様式(出血、虚血、無症候性)、血管壁造影効果(強、弱、無)、発症から撮影までの期間、鈴木分類、MRAでの狭窄進行の有無(初回と半年後のMRAを比較)を調査した。その結果、初発症状は一過性脳虚血発作16半球、脳出血3半球、脳梗塞9半球、無症候性20半球であった。狭窄部位の血管壁が強く造影されたのは9半球(18.8%)で、弱く造影されたのは16半球(33.3%)であった。6ヵ月後のMRAで狭窄進行を認めたものは9半球(18.8%)であった。血管壁造影効果を認めなかったのに狭窄が進行したのは1半球で、甲状腺機能亢進症を合併していた。もやもや病は甲状腺機能異常など自己免疫疾患と関連性があると思われた。血管狭窄や血管新生に自己免疫系が関与し、自己免疫系自体も血管内皮細胞などに直接働きかけていると考えられた。

  20. 認知機能低下を示す多系統萎縮症の解剖学的脳内ネットワーク Reviewed

    原 一洋, 渡辺 宏久, バガリナオ・エピファニオ, 川畑 和也, 大嶽 れい子, 桝田 道人, 小倉 礼, 加藤 隼康, 前澤 聡, 勝野 雅央, 長縄 慎二, 祖父江 元

    自律神経   Vol. 56 ( 2 ) page: xxiv - xxiv   2019.6

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  21. FDG-PET/CTの腫瘍代謝容積に基づいた肺腺癌の臨床病期診断の試み Reviewed

    岩野信吾, 伊藤倫太郎, 長縄慎二

    肺癌(Web)   Vol. 59 ( 2 )   2019

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  22. 原発性肺癌の術前臨床病期診断の正確性 Reviewed

    岩野信吾, 馬越弘泰, 伊藤倫太郎, 島本宏矩, 長縄慎二

      Vol. 37 ( Supplement )   2019

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  23. 人工知能が医療を変える!医療分野におけるAI研究開発最前線2019 II 領域別・画像診断におけるAI研究開発の最前線 2.胸部領域 胸部画像診断におけるAIと臨床研究について Reviewed

    伊藤倫太郎, 岩野信吾, 長縄慎二

    Innervision   Vol. 34 ( 7 ) page: 25 - 28   2019

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  24. Multi-window levels and widths imaging:画像変換による新たな読影手法の検討 Reviewed

    伊藤倫太郎, 岩野信吾, 小田紘久, 森健策, 長縄慎二

    日本医学放射線学会秋季臨床大会抄録集   Vol. 55th   2019

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  25. 多系統萎縮症において小脳萎縮は認知関連の結合性に影響する(Cerebellar atrophy influence on connectivities related to cognition in multiple system atrophy) Reviewed

    Hara Kazuhiro, Watanabe Hirohisa, Kawabata Kazuya, Bagarinao Epifanio, Ohdake Reiko, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Tsuboi Takashi, Ito Mizuki, Atsuta Naoki, Niwa Hisayoshi, Taoka Toshiaki, Maesawa Satoshi, Naganawa Shinji, Katsuno Masahisa, Sobue Gen

    臨床神経学   Vol. 58 ( Suppl. ) page: S210 - S210   2018.12

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  26. Diagnostic Radiology Service in Japan. Reviewed

    Naganawa S, Korogi Y

    Japanese journal of radiology   Vol. 36 ( 10 ) page: 575 - 578   2018.10

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    DOI: 10.1007/s11604-018-0770-z

    PubMed

  27. 認知機能低下を示す多系統萎縮症の解剖学的脳内ネットワーク Reviewed

    原 一洋, 渡辺 宏久, バガリナオ・エピファニオ, 川畑 和也, 大嶽 れい子, 桝田 道人, 小倉 礼, 加藤 隼康, 前澤 聡, 勝野 雅央, 長縄 慎二, 祖父江 元

    日本自律神経学会総会プログラム・抄録集   Vol. 71回   page: 127 - 127   2018.10

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  28. Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy Reviewed

    Hara Kazuhiro, Watanabe Hirohisa, Bagarinao Epifanio, Kawabata Kazuya, Yoneyama Noritaka, Ohdake Reiko, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Tsuboi Takashi, Ito Mizuki, Atsuta Naoki, Niwa Hisayoshi, Taoka Toshiaki, Maesawa Satoshi, Naganawa Shinji, Katsuno Masahisa, Sobue Gen

    JOURNAL OF NEUROLOGY   Vol. 265 ( 9 ) page: 2079 - 2087   2018.9

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    DOI: 10.1007/s00415-018-8923-7

    PubMed

  29. 遠隔転移を契機に発見された浸潤性小葉癌の2例 Reviewed

    松本 篤子, 石垣 聡子, 佐竹 弘子, 角田 伸行, 稲石 貴弘, 長縄 慎二

    日本医学放射線学会秋季臨床大会抄録集   Vol. 54回   page: S450 - S450   2018.9

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  30. Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain Observations by Dynamic MRI and Effect of Circadian Rhythm on Tissue Gadolinium Concentrations Reviewed

    Taoka Toshiaki, Jost Gregor, Frenzel Thomas, Naganawa Shinji, Pietsch Hubertus

    INVESTIGATIVE RADIOLOGY   Vol. 53 ( 9 ) page: 529 - 534   2018.9

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    DOI: 10.1097/RLI.0000000000000473

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  31. Myocardial motion analysis based on an optical flow method using tagged MR images Reviewed

    Daiki Tabata, Haruo Isoda, Kaori Kato, Hiroki Matsubara, Takafumi Kosugi, Takashi Kosugi, Masaki Terada, Atsushi Fukuyama, Yoshiaki Komori, Shinji Naganawa

    Radiological Physics and Technology   Vol. 11 ( 2 ) page: 202 - 211   2018.6

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    We developed a method of velocimetry based on an optical flow method using quantitative analyses of tagged magnetic resonance (MR) images (tagged MR-optical flow velocimetry, tMR-O velocimetry). The purpose of our study was to examine the accuracy of measurement of the proposed tMR-O velocimetry. We performed retrospective pseudo-electrocardiogram (ECG) gating tagged cine MR imaging on a rotating phantom. We optimized imaging parameters for tagged MR imaging, and validated the accuracy of tMR-O velocimetry. Our results indicated that the difference between the reference velocities and the computed velocities measured using optimal imaging parameters was less than 1%. In addition, we performed tMR-O velocimetry and echocardiography on 10 healthy volunteers, for four sections of the heart (apical, midventricular, and basal sections aligned with the short-axis, and a four-chamber section aligned with the long-axis), and obtained radial and longitudinal myocardial velocities in these sections. We compared the myocardial velocities obtained using tMR-O velocimetry with those obtained using echocardiography. Our results showed good agreement between tMR-O velocimetry and echocardiography in the radial myocardial velocities in three short-axial sections and longitudinal myocardial velocities on the midventricular portion of the four-chamber section in the long-axis. In the study conducted on the rotating phantom, tMR-O velocimetry showed high accuracy
    moreover, in the healthy volunteers, the myocardial velocities obtained using tMR-O velocimetry were relatively similar to those obtained using echocardiography. In conclusion, tMR-O velocimetry is a potentially feasible method for analyzing myocardial motion in the human heart.

    DOI: 10.1007/s12194-018-0456-3

    Scopus

    PubMed

  32. Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer Reviewed

    Shinji Ito, Shingo Iwano, Katsuhiko Kato, Shinji Naganawa

    Annals of Nuclear Medicine   Vol. 32 ( 6 ) page: 1 - 7   2018.5

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    Objective: To identify prognostic factors associated with a low-iodine diet (LID) and the amount of remnant thyroid tissue in Japanese patients with differentiated thyroid cancer (DTC) who received initial I-131 remnant ablation (RAI) using a fixed low dose of I-131 (1110 MBq). Patients and methods: In this prospective study, we enrolled 45 patients. Patients were classified into a self-managed LID group and a strict LID group. We measured the urinary iodine concentration on the day of RAI after patients consumed LID for 2 weeks. Thyroid-stimulating hormone-induced thyroglobulin (Tg) levels and I-131 uptake by the remnant thyroid tissue were also evaluated. A response-evaluation whole-body scan (WBS) was performed 6–8 months after RAI to determine the outcome of the therapy. Results: Post-LID urinary iodine levels of the strict LID group tended to be lower than those of the self-managed LID group. Twenty-five cases (56%) showed absence of uptake, whereas 20 cases (44%) showed residual uptake on the response-evaluation WBS. There were no significant differences between “absence” and “residual” groups in urinary iodine concentrations and Tg levels (p = 0.253 and p = 0.234, respectively). However, significant differences were observed in I-131 uptake by the thyroid bed (p = 0.035). Conclusions: For patients following the current Japanese method of a 2-week LID, the urinary iodine concentration was not a predictive factor for the successful outcome of RAI. In contrast, low I-131 uptake by the thyroid bed, revealed by the scintigram after RAI, may serve as a favorable predictive factor.

    DOI: 10.1007/s12149-018-1261-0

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    PubMed

  33. Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer Reviewed

    Suguru Yamada, Tsutomu Fujii, Yukihiro Yokoyama, Hiroki Kawashima, Osamu Maeda, Kojiro Suzuki, Tohru Okada, Eizaburo Ono, Junpei Yamaguchi, Nao Takano, Hideki Takami, Masamichi Hayashi, Yukiko Niwa, Yoshiki Hirooka, Yoshiyuki Ito, Shinji Naganawa, Yuichi Ando, Masato Nagino, Hidemi Goto, Yasuhiro Kodera

    Cancer Chemotherapy and Pharmacology   Vol. 81 ( 5 ) page: 815 - 821   2018.5

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    Purpose: For unresectable locally advanced (UR-LA) pancreatic cancer, chemoradiotherapy has been recommended by the NCCN guidelines. We designed a chemoradiotherapy protocol using nab-paclitaxel combined with gemcitabine (GnP) for patients with UR-LA pancreatic cancer. The purpose of this phase I study was to determine a recommended dose (RD) for this novel regimen. Methods: Patients with UR-LA pancreatic cancer were eligible. The frequency of dose-limiting toxicities (DLTs) was evaluated, and the RD was determined. Patients were classified according to the designated dose levels of chemoradiotherapy using the GnP regimen. After additional 6 cycles of the GnP regimen were administered, surgery was considered if the patients had stable disease and tumor marker levels had normalized. Results: DLT (grade 4 thrombocytopenia) was observed only in 1 of 12 patients, and the RD was set at level 3. Grade 3–4 leukopenia was observed in 9 (75.0%) patients, and neutropenia in 7 (58.3%). The response rate was 41.7%, and the disease control rate was 100%. Conversion surgery was performed in 6 (50%) patients, and curative resection (R0) was performed in all 6 patients (100%). Stratification according to the Evans classification system demonstrated one patient with grade 1b, one with grade 2, two with grade 3, and two with grade 4 disease. Conclusion: The RD for weekly administration was 800 mg/m2 for gemcitabine and 100 mg/m2 for nab-paclitaxel with a 50.4 Gy radiation. The GnP regimen at this dosage was promising with 6 of 12 patients proceeding to conversion surgery, and should be evaluated further in a phase II trial.

    DOI: 10.1007/s00280-018-3554-3

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    PubMed

  34. Study protocol: Prospective study of concurrent chemoradiotherapy with S-1 and hypofractionated radiotherapy for outpatients with early glottic squamous cell carcinomas Reviewed

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Seiji Kubota, Mariko Kawamura, Rie Nakahara, Yumi Oie, Yuka Kozai, Yuuki Takase, Hidenori Tsuzuki, Naoki Nishio, Mariko Hiramatsu, Yasushi Fujimoto, Takefumi Mizutani, Akihiro Hirakawa, Shinji Naganawa

    Asian Pacific Journal of Cancer Prevention   Vol. 19 ( 5 ) page: 1195 - 1199   2018.5

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    Background: The recommended treatment strategies for early glottic carcinoma with intent of larynx preservation are primarily radiotherapy. However, the outcomes of radiotherapy for bulky T1 or T2 glottic carcinoma are unsatisfactory. We designed a protocol consisting of concurrent chemoradiotherapy using S-1 as the radiosensitizer. We have performed this protocol in patients with favorable T2 lesions and demonstrated its efficacy and safety. In contrast, we have treated non-bulky T1 glottic carcinomas with 2.25 Gy per fraction, for a total of 25-28 fractions, starting in 2011 to improve efficacy and shorten the treatment period. Since this treatment strategy was implemented for T1 disease, no local failure has occurred to date, and it appears to be almost as safe as radiotherapy using 2.0 Gy per fraction. With the aim of improving the local control rate and shortening the treatment period primarily for favorable T2 disease, we changed the dose of radiation in our protocol from 2.0 Gy to 2.25 Gy per fraction, for a total of 25 fractions (from 30 fractions). The present study aims to evaluate the efficacy and safety of this new protocol. Methods: This study will be conducted as a clinical, prospective, single-armed, non-randomized trial. Patients are to receive S-1 (55.3 mg /m2 /day, once daily) and radiotherapy (2.25 Gy per fraction, for a total of 25 fractions). S-1 and radiotherapy are started on the same day that radiotherapy is performed, 3-6 hours after oral administration of S-1. The primary study aim is the 3-year local control rate. The secondary study aims are overall survival, voice-preservation survival, disease-free survival, complete response rate, completion rate, and toxicity. Result and conclusion: This is the first single-center, non-randomized, prospective study of concurrent chemoradiotherapy with S-1 and hypofractionated radiotherapy to be conducted. The trial will evaluate the efficacy and safety of our protocol.

    DOI: 10.22034/APJCP.2018.19.5.1195

    Scopus

    PubMed

  35. Longitudinal findings of MRI and PET in West syndrome with subtle focal cortical dysplasia. Reviewed

    Yoko Sakaguchi, Hiroyuki Kidokoro, Chikako Ogawa, Yu Okai, Yuji Ito, Hiroyuki Yamamoto, Atsuko Ohno, Tomohiko Nakata, Takeshi Tsuji, Toshiki Nakane, Hisashi Kawai, Katsuhiko Kato, Shinji Naganawa, Jun Natsume

    American Journal of Neuroradiology   Vol. 39 ( 10 ) page: 1932 - 1937   2018.5

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  36. Effects of gradient coil noise and gradient coil replacement on the reproducibility of resting state networks Reviewed

    Epifanio Bagarinao, Erina Tsuzuki, Yukina Yoshida, Yohei Ozawa, Maki Kuzuya, Takashi Otani, Shuji Koyama, Haruo Isoda, Hirohisa Watanabe, Satoshi Maesawa, Shinji Naganawa, Gen Sobue

    Frontiers in Human Neuroscience   Vol. 12   page: 148 - 148   2018.4

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    The stability of the MRI scanner throughout a given study is critical in minimizing hardware-induced variability in the acquired imaging data set. However, MRI scanners do malfunction at times, which could generate image artifacts and would require the replacement of a major component such as its gradient coil. In this article, we examined the effect of low intensity, randomly occurring hardware-related noise due to a faulty gradient coil on brain morphometric measures derived from T1-weighted images and resting state networks (RSNs) constructed from resting state functional MRI. We also introduced a method to detect and minimize the effect of the noise associated with a faulty gradient coil. Finally, we assessed the reproducibility of these morphometric measures and RSNs before and after gradient coil replacement. Our results showed that gradient coil noise, even at relatively low intensities, could introduce a large number of voxels exhibiting spurious significant connectivity changes in several RSNs. However, censoring the affected volumes during the analysis could minimize, if not completely eliminate, these spurious connectivity changes and could lead to reproducible RSNs even after gradient coil replacement.

    DOI: 10.3389/fnhum.2018.00148

    Scopus

  37. Efficacy of percutaneous transhepatic portal vein embolization using gelatin sponge particles and metal coils Reviewed

    Komada Tomohiro, Suzuki Kojiro, Mizuno Takashi, Ebata Tomoki, Matsushima Masaya, Naganawa Shinji, Nagino Masato

    ACTA RADIOLOGICA OPEN   Vol. 7 ( 4 ) page: 2058460118769687 - 2058460118769687   2018.4

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    DOI: 10.1177/2058460118769687

    PubMed

  38. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan Reviewed

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshihiko Wakabayashi, Masafumi Kuzuya, Norio Ozaki, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Gen Sobue

    NeuroImage   Vol. 169   page: 134 - 144   2018.4

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    This study aims to elucidate age-related intrinsic brain volume changes over the adult lifespan using an unbiased data-driven structural brain parcellation. Anatomical brain images from a cohort of 293 healthy volunteers ranging in age from 21 to 86 years were analyzed using independent component analysis (ICA). ICA-based parcellation identified 192 component images, of which 174 (90.6%) showed a significant negative correlation with age and with some components being more vulnerable to aging effects than others. Seven components demonstrated a convex slope with aging
    3 components had an inverted U-shaped trajectory, and 4 had a U-shaped trajectory. Linear combination of 86 components provided reliable prediction of chronological age with a mean absolute prediction error of approximately 7.2 years. Structural co-variation analysis showed strong interhemispheric, short-distance positive correlations and long-distance, inter-lobar negative correlations. Estimated network measures either exhibited a U- or an inverted U-shaped relationship with age, with the vertex occurring at approximately 45–50 years. Overall, these findings could contribute to our knowledge about healthy brain aging and could help provide a framework to distinguish the normal aging processes from that associated with age-related neurodegenerative diseases.

    DOI: 10.1016/j.neuroimage.2017.12.014.

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    PubMed

  39. Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson’s disease Reviewed

    Kazuya Kawabata, Hirohisa Watanabe, Kazuhiro Hara, Epifanio Bagarinao, Noritaka Yoneyama, Aya Ogura, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Reiko Ohdake, Yasuhiro Tanaka, Takashi Tsuboi, Tomohiko Nakamura, Masaaki Hirayama, Mizuki Ito, Naoki Atsuta, Satoshi Maesawa, Shinji Naganawa, Masahisa Katsuno, Gen Sobue

    Journal of Neurology   Vol. 265 ( 3 ) page: 688 - 700   2018.3

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    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:Dr. Dietrich Steinkopff Verlag GmbH and Co. KG  

    Cognitive deficits in Parkinson’s disease (PD) are heterogeneous entities, but a relationship between the heterogeneity of cognitive deficits and resting-state network (RSN) changes remains elusive. In this study, we examined five sub-domain scores according to Addenbrooke’s Cognitive Examination-Revised (ACE-R) for the cognitive evaluation and classification of 72 non-demented patients with PD. Twenty-eight patients were classified as PD with normal cognition (PD-NC). The remaining 44 were subdivided into the following 2 groups using a hierarchical cluster analysis: 20 with a predominant decrease in memory (PD with amnestic cognitive deficits: PD-A) and 24 with good memory who exhibited a decrease in other sub-domains (PD with non-amnestic cognitive deficits: PD-NA). We used an independent component analysis of RS-fMRI data to investigate the inter-group differences of RSN. Compared to the controls, the PD-A showed lower FC within the ventral default mode network (vDMN) and the visuospatial network. On the other hand, the PD-NA showed lower FC within the visual networks and the cerebellum–brainstem network. Significant differences in the FC within the vDMN and cerebellum–brainstem network were observed between the PD-A and PD-NA, which provided a good discrimination between PD-A and PD-NA using a support vector machine. Distinct patterns of cognitive deficits correspond to different RSN changes.

    DOI: 10.1007/s00415-018-8755-5.

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  40. Imaging of the endolymphatic space in patients with Ménière's disease. Reviewed

    Yoshida T, Sugimoto S, Teranishi M, Otake H, Yamazaki M, Naganawa S, Nakashima T, Sone M

    Auris, nasus, larynx   Vol. 45 ( 1 ) page: 33 - 38   2018.2

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    DOI: 10.1016/j.anl.2017.02.002

    PubMed

  41. Safety and efficacy of diagnostic flexible bronchoscopy in very old patients with lung cancer Reviewed

    Shotaro Okachi, Kazuyoshi Imaizumi, Naoyuki Imai, Takahiro Shimizu, Tetsunari Hase, Masahiro Morise, Naozumi Hashimoto, Mitsuo Sato, Yoshinori Hasegawa

    European Geriatric Medicine   Vol. 9   page: 255 - 262   2018.2

  42. Differences in Signal Intensity and Enhancement on MR Images of the Perivascular Spaces in the Basal Ganglia versus Those in White Matter. Reviewed

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka

    Magn Reson Med Sci.   Vol. 17 ( 4 ) page: 301 - 307   2018.1

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    DOI: 10.2463/mrms.mp.2017-0137.

    PubMed

  43. FDG PET/CT Overcomes Discordance Between Clinical and Pathologic TNM Classification of Small-size Primary Lung Cancer: Influence on Postoperative Prognosis Reviewed

    Hiroyasu Umakoshi, Shingo Iwano, Kohei Yokoi, Shinji Ito, Rintaro Ito, Koji Kawaguchi, Takayuki Fukui, Shinji Naganawa

    CLINICAL LUNG CANCER   Vol. 19 ( 1 ) page: E37 - E45   2018.1

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    We reviewed the concordance between the clinical stage and pathologic stage for primary lung cancer. We evaluated 289 surgically resected lung cancers <= 3 cm. Multivariate survival analysis showed that the significant predictive factors for postoperative disease-free survival were pathologic stage and the maximum standardized uptake value (SUVmax) of primary lesions. Combining SUVmax with clinical stage might improve the prediction of therapeutic outcomes.Introduction: We aimed to determine the concordance between the clinical stage (c-stage) and pathologic stage (p-stage) for patients with small-size lung cancer. Additionally we searched for prognostic factors other than the TNM stage. Patients and Methods: We retrospectively reviewed the preoperative multidetector computed tomography (CT) and positron emission tomography/CT reports, surgical records, and pathologic reports of patients with primary lung cancer <= 3 cm. The Union for International Cancer Control TNM seventh edition classification of c-stage and p-stage were compared. The tumors were classified into multiple subgroups by concordance or discordance between the c-stage and p-stage. Disease-free survival (DFS) was assessed using survival analysis to assess the tumor characteristics that were predictive of prognosis. Results: A total of 289 surgically resected primary lung cancers were evaluated. The concordance between c-stage and p-stage was 65.4%, with moderate reproducibility (kappa coefficient, 0.467). The upstaging rate from c-stage I to p-stage II-IV was 9.4%, and these patients had significantly worse DFS than those with a concordant stage I classification (P < .001). The main reason for upstaging was an underestimation of metastases to the hilar lymph nodes (n = 7) or mediastinal lymph nodes (n = 11). A multivariate Cox proportional hazards model showed that the significant predictive factors for DFS were p-stage (hazard ratio, 1.342; P = .003) and maximum standardized uptake value on positron emission tomography/CT (hazard ratio, 12.162; P = .001). Conclusion: The concordance rate between c-stage and p-stage for small primary lung cancers had moderate reproducibility. Discordance between c-stage I and p-stage II-IV significantly affected DFS. The maximum standardized uptake value of the primary lesion was an independent prognostic factor, and combining it with c-stage might improve the prediction of therapeutic outcomes.

    DOI: 10.1016/j.cllc.2017.05.021

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    PubMed

  44. Dosimetric feasibility of using tungsten-based functional paper for flexible chest wall protectors in intraoperative electron radiotherapy for breast cancer Reviewed

    Takeshi Kamomae, Hajime Monzen, Mariko Kawamura, Kuniyasu Okudaira, Takayoshi Nakaya, Takashi Mukoyama, Yoshikazu Miyake, Yoshitomo Ishihara, Yoshiyuki Itoh, Shinji Naganawa

    PHYSICS IN MEDICINE AND BIOLOGY   Vol. 63 ( 1 ) page: 015006 - 015006   2018.1

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    Intraoperative electron radiotherapy (IOERT), which is an accelerated partial breast irradiation method, has been used for early-stage breast cancer treatment. In IOERT, a protective disk is inserted behind the target volume to minimize the dose received by normal tissues. However, to use such a disk, the surgical incision must be larger than the field size because the disk is manufactured from stiff and unyielding materials. In this study, the applicability of newly developed tungsten-based functional paper (TFP) was assessed as an alternative to the existing protective disk. The radiationshielding performance of the TFP was verified through experimental measurements and Monte Carlo simulations. Percentage depth dose curves and lateral dose profiles with and without TFPs were measured and simulated on a dedicated IOERT accelerator. The number of piled-up TFPs was changed from 1 to 40. In the experimental measurements, the relative doses at the exit plane of the TFPs for 9 MeV were 42.7%, 9.2%, 0.2%, and 0.1% with 10, 20, 30, and 40 TFPs, respectively, whereas those for 12 MeV were 63.6%, 27.1%, 8.6%, and 0.2% with 10, 20, 30, and 40 TFPs, respectively. Slight dose enhancements caused by backscatter radiation from the TFPs were observed at the entrance plane of the TFPs at both beam energies. The results of the Monte Carlo simulation indicated the same tendency as the experimental measurements. Based on the experimental and simulated results, the radiation-shielding performances of 30 TFPs for 9 MeV and 40 TFPs for 12 MeV were confirmed to be acceptable and close to those of the existing protective disk. The findings of this study suggest the feasibility of using TFPs as flexible chest wall protectors in IOERT for breast cancer treatment.

    DOI: 10.1088/1361-6560/aa96cf

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  45. Prediction of Intracranial Arterial Stenosis Progression in Patients with Moyamoya Vasculopathy: Contrast-Enhanced High-Resolution Magnetic Resonance Vessel Wall Imaging Reviewed International journal

    Shinsuke Muraoka, Yoshio Araki, Toshiaki Taoka, Hisashi Kawai, Sho Okamoto, Kenji Uda, Shinji Ota, Shinji Naganawa, Toshihiko Wakabayashi

    World Neurosurgery   Vol. 116   page: E1114 - E1121   2018

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    Objective: Moyamoya vasculopathy (MMV) is characterized by progressive stenosis of the intracranial arteries. MMV currently has no curative treatments, and cerebral ischemia and hemorrhage are the major outcomes. Evaluation of the stroke risk of each patient resulting from the progression of intracranial arterial stenosis is clinically important. Methods: We prospectively reviewed patients with intracranial arterial stenosis and already diagnosed MMV. High-resolution magnetic resonance imaging using contrast agent is the novel vessel wall imaging (VWI) technique for directly evaluating vascular walls and intracranial artery disease. All patients underwent high-resolution vessel wall imaging and magnetic resonance angiography at the time of registration, and they underwent follow-up magnetic resonance angiography. The Fisher exact test was used to assess associations between the degrees of wall enhancement and between stable and progressive intracranial arterial stenosis. Results: A total of 24 patients (17 female
    mean age, 36.1 ± 16.8 years
    range 3–67 years) with MMV were consecutively recruited to this study. Progression of stenosis was shown in 6 lesions (66.6%) on strong enhancement, 2 lesions (12.5%) on mild enhancement, and 1 lesion (4.3%) on lack of enhancement. Arterial vessel wall enhancement in MMV patients correlated closely with progression of intracranial arterial stenosis (P = 0.002). Conclusions: Arterial vessel wall enhancement in MMV patients was closely related to progression of intracranial arterial stenosis. Strong enhancement of the intracranial vessel wall was associated with intracranial arterial stenosis progression, and lack of enhancement correlated with the stability of intracranial arterial stenosis.

    DOI: 10.1016/j.wneu.2018.05.181

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  46. Relationship between contrast enhancement of the perivascular space in the basal ganglia and endolymphatic volume ratio Reviewed

    Toshio Ohashi, Shinji Naganawa, Toshio Katagiri, Kayao Kuno

    Magnetic Resonance in Medical Sciences   Vol. 17 ( 1 ) page: 67 - 72   2018

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    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:Japanese Society for Magnetic Resonance in Medicine  

    Purpose: We routinely obtain the endolymphatic hydrops (EH) image using heavily T2-weighted three dimensional-fluid attenuated inversion recovery (hT2w-3D-FLAIR) imaging at 4 hours after intravenous administration of a single-dose of gadolinium-based contrast media (IV-SD-GBCM). While repeating the examination, we speculated that the contrast enhancement of the perivascular space (PVS) in the basal ganglia might be related to the degree of EH. Therefore, the purpose of this study was to investigate the relationship between the endolymphatic volume ratio (%ELvolume) and the signal intensity of the PVS (SI-PVS). Materials and Methods: In 20 patients with a suspicion of EH, a heavily T2-weighted 3D-turbo spin echo sequence for MR cisternography (MRC) and an hT2w-3D-FLAIR as a positive perilymph image (PPI) were obtained at 4 hours after IV-SD-GBCM. The %ELvolume of the cochlea and the vestibule were measured on the previously reported HYDROPS2-Mi2 image. The PVS in the basal ganglia was segmented on MRC using a region-growing method. The PVS regions were copied and pasted onto the PPI, and the SI-PVS was measured. The larger value of the right and the left ears was employed as the %ELvolume, and the weighted average of both sides was employed as the SI-PVS. The correlation between the %ELvolume and the SI-PVS was evaluated. Result: There was a strong negative linear correlation between the %ELvolume of the cochlea and the SI-PVS (r = −0.743, P &lt
    0.001)
    however, there was no significant correlation between the %ELvolume of the vestibule and the SI-PVS (r = −0.267, P = 0.256). Conclusion: There was a strong negative correlation between the cochlear %ELvolume and the SI-PVS. Contrast enhancement of PVS might be a biomarker of EH.

    DOI: 10.2463/mrms.mp.2017-0001

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  47. Generative Adversarial Networkを用いた肺結節の画像生成について Reviewed

    伊藤倫太郎, 岩野信吾, 長縄慎二

    日本医学放射線学会秋季臨床大会抄録集   Vol. 54th   2018

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    J-GLOBAL

  48. 非小細胞肺癌の局所浸潤性の予測に関する造影dual energy CTとFDG-PET/CTの比較 Reviewed

    伊藤倫太郎, 岩野信吾, 島本宏矩, 馬越弘泰, 伊藤信嗣, 長縄慎二, 加藤克彦

    Japanese Journal of Radiology   Vol. 36 ( Supplement )   2018

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  49. 胸壁並行断面CTを用いた間質性肺炎の経時的評価 Reviewed

    馬越弘泰, 岩野信吾, 伊藤倫太郎, 島本宏矩, 長縄慎二

    Japanese Journal of Radiology   Vol. 36 ( Supplement )   2018

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    J-GLOBAL

  50. Longitudinal Up-Regulation of Endolymphatic Hydrops in Patients with Meniere's Disease During Medical Treatment Reviewed

    Fukushima Munehisa, Kitahara Tadashi, Oya Ryohei, Akahani Shiro, Inohara Hidenori, Naganawa Shinji, Takeda Noriaki

    LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY   Vol. 2 ( 6 ) page: 344 - 350   2017.12

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    Objective/Hypothesis: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments.Study Design: Prospective, single-arm repeated measuresMethods: Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months.Results: The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level.Conclusion: EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period.

    DOI: 10.1002/lio2.115

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  51. Three-dimensional printer-generated patient-specific phantom for artificial in vivo dosimetry in radiotherapy quality assurance Reviewed

    Takeshi Kamomae, Hidetoshi Shimizu, Takayoshi Nakaya, Kuniyasu Okudaira, Takahiro Aoyama, Hiroshi Oguchi, Masataka Komori, Mariko Kawamura, Kazuhiro Ohtakara, Hajime Monzen, Yoshiyuki Itoh, Shinji Naganawa

    PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS   Vol. 44   page: 205 - 211   2017.12

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    Pretreatment intensity-modulated radiotherapy quality assurance is performed using simple rectangular or cylindrical phantoms; thus, the dosimetric errors caused by complex patient-specific anatomy are absent in the evaluation objects. In this study, we construct a system for generating patient-specific three-dimensional (3D)printed phantoms for radiotherapy dosimetry. An anthropomorphic head phantom containing the bone and hollow of the paranasal sinus is scanned by computed tomography (CT). Based on surface rendering data, a patient-specific phantom is formed using a fused-deposition-modeling-based 3D printer, with a polylactic acid filament as the printing material. Radiophotoluminescence glass dosimeters can be inserted in the 3D-printed phantom. The phantom shape, CT value, and absorbed doses are compared between the actual and 3D-printed phantoms. The shape difference between the actual and printed phantoms is less than 1 mm except in the bottom surface region. The average CT value of the infill region in the 3D-printed phantom is -6 +/- 18 Hounsfield units (HU) and that of the vertical shell region is 126 +/- 18 HU. When the same plans were irradiated, the dose differences were generally less than 2%. These results demonstrate the feasibility of the 3D-printed phantom for artificial in vivo dosimetry in radiotherapy quality assurance.

    DOI: 10.1016/j.ejmp.2017.10.005

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  52. Clinical outcomes of I-125 brachytherapy with and without external-beam radiation therapy for localized prostate cancer: results from 300 patients at a single institution in Japan Reviewed

    Sayo Maki, Yoshiyuki Itoh, Seiji Kubota, Tohru Okada, Rie Nakahara, Junji Ito, Mariko Kawamura, Shinji Naganawa, Yasushi Yoshino, Takashi Fujita, Masashi Kato, Momokazu Gotoh, Mitsuru Ikeda

    JOURNAL OF RADIATION RESEARCH   Vol. 58 ( 6 ) page: 870 - 880   2017.11

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    The aim of this study was to determine the outcomes and adverse events for 300 men with prostate cancer treated with (125)iodine (I-125) brachytherapy with and without external-beam radiation therapy (EBRT) at a single institution in Japan. Between February 2005 and November 2011, 300 consecutive patients with clinically localized prostate cancer were treated with I-125 brachytherapy at the Nagoya University Hospital. A total of 271 men were treated with implants with doses of 145 Gy, and 29 men were treated with implants with doses of 110 Gy combined with EBRT (40-50 Gy/20-25 fractions). The median patient age was 69 years (range, 53-83 years). The median follow-up period was 53 months (range, 5-99 months). According to the National Comprehensive Cancer Network risk classification, 132 men (44%) had low-risk, 147 men (29%) had intermediate-risk and 21 men (7%) had high-risk disease. The 5-year overall survival rate, biochemical relapse-free survival rate, and disease-specific survival rates were 93.5%, 97.3% and 98.5%, respectively. Two men (0.6%) died of prostate cancer and 10 men (3.3%) died of other causes. Seventeen men (5.6%) experienced Grade 2 rectal bleeding in all: 12 (41.4%) of 29 in brachytherapy with EBRT, and 5 (1.8%) of 271 in brachytherapy alone. The rates of Grade 2 and 3 genitourinary toxicity were 1.0% and 1.7%, respectively. Excellent local control was achieved at our hospital for localized prostate cancer with I-125 brachytherapy with and without EBRT. Gastrointestinal and genitourinary toxicities were acceptable.

    DOI: 10.1093/jrr/rrx051

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  53. The Relationship Between Endolymphatic Hydrops in the Vestibule and Low-Frequency Air-Bone Gaps. Reviewed

    Satofumi Sugimoto, Tadao Yoshida, Masaaki Teranishi, Yuriko Okazaki, Shinji Naganawa, Michihiko Sone

    Laryngoscope.   Vol. 128 ( 7 ) page: 1658 - 1662   2017.11

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    DOI: 10.1002/lary.26898.

  54. Structural MRI correlates of amyotrophic lateral sclerosis progression Reviewed

    Joe Senda, Naoki Atsuta, Hirohisa Watanabe, Epifanio Bagarinao, Kazunori Imai, Daichi Yokoi, Yuichi Riku, Michihito Masuda, Ryoichi Nakamura, Hazuki Watanabe, Mizuki Ito, Masahisa Katsuno, Shinji Naganawa, Gen Sobue

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   Vol. 88 ( 11 ) page: 901 - 907   2017.11

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    Purpose Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical course and progression of ALS varies widely. Brain degeneration detected using structural MRI could reflect disease progression.
    Subjects and methods On study registration, 3-Tesla volumetric MRI and diffusion tensor imaging scans were obtained at baseline in 38 healthy controls and 67 patients with sporadic ALS. Patients had Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) scores of &gt;= 36 and did not have the chromosome 9, open reading frame 72 repeat expansion. Six months later, changes in ALSFRS-R (Delta ALSFRS-R) scores were calculated and patients were grouped into three categories, namely, patients with slow progression with Delta ALSFRS-R scores &lt;= 3 (n=19), intermediate progression with Delta ALSFRS-R scores =4, 5 and 6 (n=36) and rapid progression with Delta ALSFRS-R scores &gt;= 7 (n=12). We analysed voxel-based morphometry and tract-based spatial statistics among these subgroups and controls.
    Results In comparison with controls, patients with ALS showed grey matter atrophy and decreased fractional anisotropy beyond the motor cortex and CST, especially in the frontotemporal lobes and basal ganglia. Moreover, the degree of change was highly proportional to Delta ALSFRS-R at the 6-month assessment.
    Conclusion A more rapid disease progression and poorer functional decline were associated with greater involvement of the extra-motor cortex and basal ganglia, suggesting that the spatial extent of brain involvement can be an indicator of the progression in ALS.

    DOI: 10.1136/jnnp-2016-314337

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  55. Detecting sub-second changes in brain activation patterns during interictal epileptic spike using simultaneous EEG-fMRI. Reviewed

    Epifani Bagarinao, Satoshi Maesawa, Yuji Ito, Naotaka Usui, Jun Natsume, Hirohisa Watanabe, Minoru Hoshiyama, Toshihiko Wakabayashi, Gen Sobue, Shinji Naganawa, Haruo Isoda

    Clin Neurophysiol   Vol. 129 ( 2 ) page: 377 - 389   2017.11

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    PubMed

  56. A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological invasiveness of non-small cell lung cancer Reviewed

    Rintaro Ito, Shingo Iwano, Hironori Shimamoto, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Ito, Katsuhiko Kato, Shinji Naganawa

    EUROPEAN JOURNAL OF RADIOLOGY   Vol. 95 ( 95 ) page: 186 - 191   2017.10

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    Purpose: To compare dual-phase dual-energy CT (DE-CT) with FDG-PET/CT for predicting histopathological locoregional invasiveness of non-small cell lung cancers (NSCLCs).
    Materials and methods: We selected 63 consecutive patients with NSCLC lesions (37 males, 26 females; age range, 44-85 years; mean age, 69 years) who were evaluated preoperatively by both DE-CT and PET/CT at our institution. Postoperative microscopic invasiveness (lymphatic permeation, vascular invasion, and/or pleural involvement) was reviewed, and we defined locoregionally invasive tumors as those that had at least one positive finding of microscopic invasiveness. DE-CT scanning in the arterial and delayed phases was performed after injection of iodinated contrast media using 140-kVp and 80-kVp tube voltages. Three-dimensional iodine-related attenuation of primary tumors in the arterial and delayed phases was quantified automatically using "syngo Dual Energy Lung Nodules" application software, and the ratio of arterial phase to delayed phase enhancement (A/D ratio) was calculated. The A/D ratio and SUVmax on PET/CT were evaluated with respect to postoperative invasiveness by univariate logistic regression analysis.
    Results: The A/D ratio was significantly correlated with lymphatic permeation, vascular invasion, and pleural involvement (p = 0.011, p = 0.021, and p = 0.010, respectively). In contrast, the SUVmax was significantly correlated with pleural involvement (p = 0.020) but not with lymphatic permeation or vascular invasion (p = 0.088 and p = 0.100, respectively). In the subgroup of patients with lesion diameters &lt;= 2 cm, the A/D ratio was significantly correlated with locoregional invasiveness (p = 0.040), while the SUVmax was not (p = 0.121).
    Conclusion: For the prediction of microscopic invasiveness of NSCLCs, the diagnostic performance of dual-phase DE-CT may be comparable to that of FDG-PET/CT.

    DOI: 10.1016/j.ejrad.2017.08.010.

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  57. A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological invasiveness of non-small cell lung cancer Reviewed

    Rintaro Ito, Shingo Iwano, Hironori Shimamoto, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Ito, Katsuhiko Kato, Shinji Naganawa

    EUROPEAN JOURNAL OF RADIOLOGY   Vol. 95   page: 186 - 191   2017.10

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    Purpose: To compare dual-phase dual-energy CT (DE-CT) with FDG-PET/CT for predicting histopathological locoregional invasiveness of non-small cell lung cancers (NSCLCs).
    Materials and methods: We selected 63 consecutive patients with NSCLC lesions (37 males, 26 females; age range, 44-85 years; mean age, 69 years) who were evaluated preoperatively by both DE-CT and PET/CT at our institution. Postoperative microscopic invasiveness (lymphatic permeation, vascular invasion, and/or pleural involvement) was reviewed, and we defined locoregionally invasive tumors as those that had at least one positive finding of microscopic invasiveness. DE-CT scanning in the arterial and delayed phases was performed after injection of iodinated contrast media using 140-kVp and 80-kVp tube voltages. Three-dimensional iodine-related attenuation of primary tumors in the arterial and delayed phases was quantified automatically using "syngo Dual Energy Lung Nodules" application software, and the ratio of arterial phase to delayed phase enhancement (A/D ratio) was calculated. The A/D ratio and SUVmax on PET/CT were evaluated with respect to postoperative invasiveness by univariate logistic regression analysis.
    Results: The A/D ratio was significantly correlated with lymphatic permeation, vascular invasion, and pleural involvement (p = 0.011, p = 0.021, and p = 0.010, respectively). In contrast, the SUVmax was significantly correlated with pleural involvement (p = 0.020) but not with lymphatic permeation or vascular invasion (p = 0.088 and p = 0.100, respectively). In the subgroup of patients with lesion diameters &lt;= 2 cm, the A/D ratio was significantly correlated with locoregional invasiveness (p = 0.040), while the SUVmax was not (p = 0.121).
    Conclusion: For the prediction of microscopic invasiveness of NSCLCs, the diagnostic performance of dual-phase DE-CT may be comparable to that of FDG-PET/CT.

    DOI: 10.1016/j.ejrad.2017.08.010

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  58. Three-dimensional printer-generated patient-specific phantom for artificial in vivo dosimetry in radiotherapy quality assurance. Reviewed

    Takeshi Kamomae, Hidetoshi Shimizu, Takayoshi Nakaya, Kuniyasu Okudaira, Takahiro Aoyama, Hiroshi Oguchi, Masataka Komori, Mariko Kawamura, Kazuhiro Ohtakara, Hajime Monzen, Yoshiyuki Itoh, Shinji Naganawa

    Phys Med.   Vol. 44   page: 205 - 211   2017.10

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    DOI: 10.1016/j.ejmp.2017.10.005.

  59. Longitudinal Up-Regulation of Endolymphatic Hydrops in Patients with Meniere's Disease During Medical Treatment. Reviewed

    Munehisa Fukushima, Tadashi Kitahara, Ryohei Oya, Shiro Akahani, Hidenori Inohara, Shinji Naganawa, Noriaki Takeda

    Laryngoscope Investigative Otolaryngology.   Vol. 2 ( 6 ) page: 344 - 350   2017.10

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  60. I期食道癌の根治的放射線治療の臨床成績 Reviewed

    小出 雄太郎, 古平 毅, 立花 弘之, 富田 夏夫, 牧田 智誉子, 伊藤 誠, 安部 哲也, 室 圭, 田近 正洋, 丹羽 康正, 伊藤 善之, 長縄 慎二

    日本癌治療学会学術集会抄録集   Vol. 55回   page: 127   2017.10

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  61. Improved HYDROPS: Imaging of Endolymphatic Hydrops after Intravenous Administration of Gadolinium. Reviewed

    Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Michihiko Sone

    Magn Reson Med Sci.   ( 16 ) page: 357 - 361   2017.10

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    DOI: 10.2463/mrms.tn.2016-0126

  62. Clinical usefulness of MLCs in robotic radiosurgery systems for prostate SBRT Reviewed

    Masashi Tomida, Takeshi Kamomae, Junji Suzuki, Yoichi Ohashi, Yoshiyuki Itoh, Hiroshi Oguchi, Takahito Okuda

    JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS   Vol. 18 ( 5 ) page: 124 - 133   2017.9

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    Stereotactic body radiation therapy (SBRT) using recently introduced multileaf collimators (MLC) is preferred over circular collimators in the treatment of localized prostate cancer. The objective of this study was to assess the clinical usefulness of MLCs in prostate SBRT by comparing the effectiveness of treatment plans using fixed collimators, variable collimators, and MLCs and by ensuring delivery quality assurance (DQA) for each. For each patient who underwent conventional radiation therapy for localized prostate cancer, mock SBRT plans were created using a fixed collimator, a variable collimator, and an MLC. The total MUs, treatment times, and dose-volume histograms of the planning target volumes and organs at risk for each treatment plan were compared. For DQA, a phantom with a radiochromic film or an ionization chamber was irradiated in each plan. We performed gamma-index analysis to evaluate the consistency between the measured and calculated doses. The MLC-based plans had an similar to 27% lower average total MU than the plans involving other collimators. Moreover, the average estimated treatment time for the MLC plan was 31% and 20% shorter than that for the fixed and variable collimator plans respectively. The gamma-index passing rate in the DQA using film measurements was slightly lower for the MLC than for the other collimators. The DQA results acquired using the ionization chamber showed that the discrepancies between the measured and calculated doses were within 3% in all cases. The results reinforce the usefulness of MLCs in robotic radiosurgery for prostrate SBRT treatment planning; most notably, the total MU and treatment time were both reduced compared to the cases using other types of collimators. Moreover, although the DQA results based on film dosimetry yielded a slightly lower gamma-index passing rate for the MLC than for the other collimators, the MLC accuracy was determined to be sufficient for clinical use.

    DOI: 10.1002/acm2.12128

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  63. 脈絡膜悪性黒色腫の診断におけるIMP SPECT、FDG PET/CT、FDOPA PET/CTの比較 Reviewed

    加藤 克彦, 小田川 哲郎, 阿部 真治, 山口 博司, 伊藤 倫太郎, 伊藤 信嗣, 岩野 信吾, 長縄 慎二

    核医学   Vol. 54 ( Suppl. ) page: S194 - S194   2017.9

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  64. Significance of Endolymphatic Hydrops in Ears With Unilateral Sensorineural Hearing Loss Reviewed

    Yuriko Okazaki, Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Ken Kato, Shinji Naganawa, Michihiko Sone

    OTOLOGY & NEUROTOLOGY   Vol. 38 ( 8 ) page: 1076 - 1080   2017.9

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    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    Objective: The purpose of this study was to investigate the existence of endolymphatic hydrops (EH) in affected and unaffected ears in patients with unilateral sensorineural hearing loss (SNHL) using contrast-enhanced magnetic resonance imaging (MRI), and to evaluate the significance of EH in various otological diseases.
    Study Design: Retrospective study.
    Setting: University hospital.
    Methods: One hundred eighty-two ears from 91 patients with unilateral SNHL were studied. The endolymphatic space was evaluated using 3-Tesla MRI with gadodiamide hydrate. Imaging data about the degree of EH in the cochlea and vestibule were analyzed and compared between ears with various otological diseases.
    Results: All affected ears with delayed endolymphatic hydrops had EH. In affected ears with definite Menie` re's disease, cochlear EH was observed in all ears and vestibular EH in 93% of ears, and these rates were significantly higher in the affected than in the unaffected ears. EH was also observed in the cochlea and vestibule in 66% and 41%, respectively, of the affected ears with idiopathic sudden SNHL; however, these percentages did not differ significantly from those in the unaffected ears (52% and 38%, respectively).
    Conclusion: MRI showed that a high percentage of ears affected by Menie` re's disease or delayed endolymphatic hydrops had EH. Further studies should evaluate the implications of EH in ears, especially in those with sudden SNHL, in terms of secondary or pre-existing EH.

    DOI: 10.1097/MAO.0000000000001499.

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  65. Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall: A pilot study Reviewed

    Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    PLOS ONE   Vol. 12 ( 9 ) page: e0185532 - e0185532   2017.9

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    Objectives
    To quantify the imaging findings of patients with interstitial pneumonia (IP) and emphysema using three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall, and compare the results to visual assessment of IP and each patient's diffusing capacity of the lungs for carbon monoxide (DLco).
    Methods
    We retrospectively reviewed the axial CT findings and pulmonary function test results of 95 patients with lung cancer (72 men and 23 women, aged 45-84 years) with or without IP, as follows: non-IP (n = 47), mild IP (n = 31), and moderate IP (n = 17). The 3D-cHRCT images of the lung at a 1-cm depth from the chest wall were reconstructed automatically using original software; total area (TA), high-attenuation area (HAA) &gt;-500 HU, and low-attenuation area (LAA) &lt;-950 HU were calculated on a workstation. The % HAA and % LAA were calculated as follows: % HAA = HAA/TA x 100, and % LAA = LAA/TA x100.
    Results
    The % HAA and % LAA respective values were 3.2 +/- 0.9 and 27.7 +/- 8.2, 3.9 +/- 1.2 and 27.6 +/- 5.9, and 6.9 +/- 2.2 and 25.4 +/- 8.7 in non-IP, mild IP, and moderate IP patients, respectively. There were significant differences in % HAA between the 3 groups of patients (P&lt;0.001), but no differences in % LAA (P = 0.558). Multiple linear regression analysis revealed that % HAA and % LAA were negatively correlated with predicted DLco (standard partial regression coefficient [b*] = -0.453, P&lt;0.001; b* = -0.447, P&lt;0.001, respectively).
    Conclusions
    The % HAA and % LAA values computed using 3D-cHRCT were significantly correlated with DLco and may be important quantitative parameters for both IP and emphysema.

    DOI: 10.1371/journal.pone.0185532.

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  66. PET/CTは小型肺癌のTNM分類に基づく術後予後予測を補助する Reviewed

    岩野 信吾, 馬越 弘泰, 伊藤 倫太郎, 伊藤 信嗣, 川口 晃司, 福井 高幸, 横井 香平, 加藤 克彦, 長縄 慎二

    核医学   Vol. 54 ( Suppl. ) page: S195 - S195   2017.9

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  67. PET/CTによる小型肺癌の術後予後予測 臨床病期と病理病期との比較 Reviewed

    岩野 信吾, 伊藤 倫太郎, 長縄 慎二, 川口 晃司, 福井 高幸, 横井 香平

    肺癌   Vol. 57 ( 5 ) page: 453 - 453   2017.9

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  68. Detection of endolymphatic hydrops using traditional MR imaging sequences Reviewed

    Shinji Naganawa, Michihiko Sone

    AMERICAN JOURNAL OF OTOLARYNGOLOGY   Vol. 38 ( 5 ) page: 637 - 638   2017.9

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    DOI: 10.1016/j.amjoto.2017.06.014

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  69. FDG-PET/CT predicts survival and lung metastasis of hypopharyngeal cancer in a multi-institutional retrospective study Reviewed

    Hidenori Suzuki, Katsuhiko Kato, Masami Nishio, Tsuneo Tamaki, Yasushi Fujimoto, Mariko Hiramatsu, Nobuhiro Hanai, Takeshi Kodaira, Yoshiyuki Itoh, Shinji Naganawa, Michihiko Sone, Yasuhisa Hasegawa

    ANNALS OF NUCLEAR MEDICINE   Vol. 31 ( 7 ) page: 514 - 520   2017.8

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    Objectives We investigated a possible correlation between the maximum standardized uptake value (SUVmax), which is assessed by pretreatment F-18-fluorodeoxyglucose positron emission tomography with computed tomography, and the overall survival (OS) in patients with hypopharyngeal squamous cell carcinoma from two institutions on longterm follow-up, and examined whether SUVmax is correlated with several survival outcomes, including lung metastasis-free survival.Methods A total of 81 patients were enrolled. The survival rate was calculated by the Kaplan-Meier method. Both univariate and multivariate survival analyses were assessed by a Cox proportional hazards model.Results SUVmax >= 15.2 in institution A (p = 0.0306) or SUVmax >= 8 in institution B (p = 0.0132) was significantly predictor of a lower OS. We disaggregated the data by high SUVmax (SUVmax >= 15.2 from institution A and SUVmax >= 8 from institution B) and low SUVmax (SUVmax<15.2 from institution A and SUVmax <8 from institution B). Patients with a high SUVmax exhibited a significantly lower OS in both univariate (p = 0.001) and multivariate (p = 0.0046) analyses for adjusted for the clinical stage and treatment group. The patients with a high SUVmax exhibited significantly shorter disease-specific (p = 0.0068), distant metastasis-free (p = 0.0428), and lung metastasis-free (p = 0.0328) survivals.Conclusions High SUVmax was significantly correlated with a lower OS, disease-specific survival, distant metastasis- free survival, and lung metastasis-free survival in a multi-institutional retrospective study.

    DOI: 10.1007/s12149-017-1176-1.

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  70. 乳腺腺筋上皮腫(adenomyoepithelioma)の1例 Reviewed

    荒川 紗季, 石垣 聡子, 佐竹 弘子, 林 葉子, 田所 匡典, 角田 伸行, 長縄 慎二

    日本医学放射線学会秋季臨床大会抄録集   Vol. 53回   page: S452 - S453   2017.8

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  71. Optimized treatment strategy of radiotherapy for early glottic squamous cell carcinomas: An initial analysis Reviewed

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Seiji Kubota, Mariko Kawamura, Rie Nakahara, Yumi Oie, Yuka Kozai, Yuuki Takase, Hidenori Tsuzuki, Naoki Nishio, Mariko Hiramatsu, Yasushi Fujimoto, Takefumi Mizutani, Shinji Naganawa

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 3 ) page: 331 - 338   2017.8

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    The purpose of this study was to evaluate the clinical outcomes of radiotherapy for patients with T1/T2 glottic carcinoma. Patients with T1/T2 glottic carcinoma histopathologically diagnosed with squamous cell carcinoma and treated at our hospital between 2007 and 2015 were analyzed retrospectively. Our strategy for T1/T2 glottic carcinoma was as follows: radiotherapy alone with 2.25 Gy per fraction to a total of 25-28 fractions for patients with non-bulky T1 glottic carcinoma; concurrent chemoradiotherapy with oral S-1 and radiotherapy with 2 Gy per fraction to a total of 30 fractions for patients with T1 bulky/T2 favorable glottic carcinoma; or chemoradiotherapy with high-dose cisplatin and radiotherapy with 2 Gy per fraction to a total of 35 fractions for T2 unfavorable glottic carcinoma. Forty-eight patients were eligible. The median follow-up period among surviving patients was 38 months (range, 11-107). The disease was T1a in 23%, T1b in 13%, and T2 in 65% of patients. The 3-year local control rate in all patients, T1a, T1b, and T2 was 96.7%, 100%, 100%, and 96.0%, respectively. Of the 46 patients, one with T2 glottic carcinoma developed recurrent disease at the primary site, and one with T2 glottic carcinoma had lymph node recurrences in the neck. Acute Grade 3 dermatitis occurred in 8 (17%) patients and late Grade 2 hypothyroidism occurred in 2 (4%) patients. This retrospective study shows that our optimized treatment strategy of radiotherapy depending on the stage of early glottic carcinoma is not only effective but also well-tolerated.

    DOI: 10.18999/nagjms.79.3.331

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  72. FDG-PET/CT predicts survival and lung metastasis of hypopharyngeal cancer in a multi-institutional retrospective study Reviewed

    Hidenori Suzuki, Katsuhiko Kato, Masami Nishio, Tsuneo Tamaki, Yasushi Fujimoto, Mariko Hiramatsu, Nobuhiro Hanai, Takeshi Kodaira, Yoshiyuki Itoh, Shinji Naganawa, Michihiko Sone, Yasuhisa Hasegawa

    ANNALS OF NUCLEAR MEDICINE   Vol. 31 ( 7 ) page: 514 - 520   2017.8

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    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:SPRINGER  

    Objectives We investigated a possible correlation between the maximum standardized uptake value (SUVmax), which is assessed by pretreatment F-18-fluorodeoxyglucose positron emission tomography with computed tomography, and the overall survival (OS) in patients with hypopharyngeal squamous cell carcinoma from two institutions on longterm follow-up, and examined whether SUVmax is correlated with several survival outcomes, including lung metastasis-free survival.Methods A total of 81 patients were enrolled. The survival rate was calculated by the Kaplan-Meier method. Both univariate and multivariate survival analyses were assessed by a Cox proportional hazards model.Results SUVmax >= 15.2 in institution A (p = 0.0306) or SUVmax >= 8 in institution B (p = 0.0132) was significantly predictor of a lower OS. We disaggregated the data by high SUVmax (SUVmax >= 15.2 from institution A and SUVmax >= 8 from institution B) and low SUVmax (SUVmax<15.2 from institution A and SUVmax <8 from institution B). Patients with a high SUVmax exhibited a significantly lower OS in both univariate (p = 0.001) and multivariate (p = 0.0046) analyses for adjusted for the clinical stage and treatment group. The patients with a high SUVmax exhibited significantly shorter disease-specific (p = 0.0068), distant metastasis-free (p = 0.0428), and lung metastasis-free (p = 0.0328) survivals.Conclusions High SUVmax was significantly correlated with a lower OS, disease-specific survival, distant metastasis- free survival, and lung metastasis-free survival in a multi-institutional retrospective study.

    DOI: 10.1007/s12149-017-1176-1

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  73. Development of the breast immobilization system in prone setup: The effect of bra in prone position to improve the breast setup error Reviewed

    Mariko Kawamura, Yoshikazu Maeda, Kazutaka Yamamoto, Shigeyuki Takamatsu, Yoshitaka Sato, Hiroki Minami, Yusuke Saga, Kyo Kume, Yuji Tameshige, Makoto Sasaki, Hiroyasu Tamamura, Kouji Ohta, Yoshiyuki Itoh, Shinji Naganawa

    JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS   Vol. 18 ( 4 ) page: 155 - 160   2017.7

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    Purpose/objective(s): Accurate and reproducible positioning of the breast is difficult due to its deformability and softness; thus, targeting a breast tumor or tumor bed with fractionated radiotherapy using external beam radiation is difficult. The aim of this study was to develop a novel bra to aid in breast immobilization in the prone position.
    Materials & methods: To assess the accuracy of prone position fixation of breast tumors, 33 breast cancer patients with 34 lesions were recruited. The bra used in this verification was customized from a commercially available bra. Duplicate MRI were acquired in the prone position, alternating with and without the bra, and for each series, patients were asked to step off the MRI table and re-set up in the prone position. Patients were also asked to remove and re-fit the bra for the second MRI. Each pair of images were superimposed to match the shape of the skin surface, and the maximum difference in tumor geometric center in three axes was measured. The required set up margin was calculated as: required margin = mean difference in geometric center + 2.5 standard deviation. The volumetric overlap of the tumor, as well as contouring uncertainties, was evaluated using contour analysis software.
    Results: The median breast size was 498 cc. The required margins for the lateral, vertical, and longitudinal directions were estimated to be 4.1, 4.1, and 5.0 mm, respectively, with the bra, and 5.1, 6.9, and 6.7 mm, respectively, without the bra. These margins covered the dislocation of more than 33 lesions in total. With the bra, 33 lesions had achieved an objective overlap of 95% and 99% with 2 and 4 mm margins, respectively, whereas 4 and 8 mm, respectively, were needed without the bra.
    Conclusion: The use of an immobilizing bra reduced the setup margin for prone position fixation of breast tumors.

    DOI: 10.1002/acm2.12116

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  74. Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue Reviewed

    Gregor Jost, Thomas Frenzel, Jessica Lohrke, Diana Constanze Lenhard, Shinji Naganawa, Hubertus Pietsch

    EUROPEAN RADIOLOGY   Vol. 27 ( 7 ) page: 2877 - 2885   2017.7

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    Signal hyperintensity on unenhanced MRI in certain brain regions has been reported after multiple administrations of some, but not all, gadolinium-based contrast agents (GBCAs). One potential initial pathway of GBCA entry into the brain, infiltration from blood into the cerebrospinal fluid (CSF), was systematically evaluated in this preclinical study.
    GBCA infiltration and distribution in the CSF were investigated in healthy rats using repeated fluid-attenuated MRI up to 4 h after high-dose (1.8 mmol/kg) administration of six marketed and one experimental GBCA. Additionally, gadolinium measurements in CSF, blood and brain tissue samples (after 24 h) were performed using inductively coupled plasma mass spectrometry.
    Enhanced MRI signals in the CSF spaces with similar distribution kinetics were observed for all GBCAs. No substantial differences in the gadolinium concentrations among the marketed GBCAs were found in the CSF, blood or brain tissue. After 4.5 h, the concentration in the CSF was clearly higher than in blood but was almost completely cleared and lower than the brain tissue concentration after 24 h.
    In contrast to the brain signal hyperintensities, no differences in penetration and distribution into the CSF of healthy rats exist among the marketed GBCAs.
    aEuro cent Gadolinium-based contrast agents can cross the blood-CSF barrier.
    aEuro cent Fluid-attenuated MRI shows GBCA distribution with CSF flow.
    aEuro cent GBCA structure and physicochemical properties do not impact CSF penetration and distribution.
    aEuro cent GBCA clearance from CSF was almost complete within 24 h in rats.
    aEuro cent CSF is a potential pathway of GBCA entry into the brain.

    DOI: 10.1007/s00330-016-4654-2

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  75. Effect of Gadolinium Deposition on 18F-FDG PET/CT of Dentate Nucleus and Globus Pallidus. Reviewed

    Shinji Naganawa

    J Nucl Med Technol.   Vol. 45 ( 2 ) page: 173 - 173   2017.6

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  76. Letter to Editors: Detection of endolymphatic hydrops using traditional MR imaging sequences. Reviewed

    Shinji Naganawa, Michihiko Sone

    Am J Otolaryngol.   Vol. 38 ( 5 ) page: 637 - 638   2017.6

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  77. FDG PET/CT Overcomes Discordance Between Clinical and Pathologic TNM Classification of Small-size Primary Lung Cancer: Influence on Postoperative Prognosis. Reviewed

    Hiroyasu Umakoshi, Shingo Iwano, Kohei Yokoi, Shinji Ito, Rintaro Ito, Koji Kawaguchi, Takayuki Fukui, Shinji Naganawa

    Clin Lung Cancer.   Vol. 19 ( 1 ) page: e37 - e45   2017.6

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  78. Comparison of accumulation of F-18-FLT PET/CT with histopathological findings of primary and metastatic lesions of urinary tract tumors Reviewed

    Katsuhiko Kato, Shinji Abe, Shinichiro Matsuzawa, Ryuto Mukumoto, Tetsuro Odagawa, Shinji Naganawa

    JOURNAL OF NUCLEAR MEDICINE   Vol. 58   page: - - -   2017.5

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  79. Clinical outcome of definitive radiation therapy for superficial esophageal cancer Reviewed

    Yutaro Koide, Takeshi Kodaira, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Makoto Itoh, Tetsuya Abe, Kei Muro, Masahiro Tajika, Yasumasa Niwa, Yoshiyuki Itoh, Shinji Naganawa

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 47 ( 5 ) page: 393 - 400   2017.5

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    Concurrent chemoradiotherapy without intracavitary brachytherapy was effective and safe for superficial esophageal cancer, even in elderly patients.To analyze the clinical outcome of concurrent chemoradiotherapy in superficial esophageal cancer patients.We retrospectively analyzed data for 123 patients with superficial esophageal cancer who received external beam radiotherapy without intracavitary brachytherapy plus systemic chemotherapy during 1998-2015. Elective nodal irradiation was not performed. The dosage to planning treatment volume was 60 Gy in 30 fractions. The main outcome measure was overall survival.Patient characteristics were as follows: median age, 66 (41-83) years; male/female ratio, 106/17; squamous cell carcinoma/other, 122/1; cT1a/cT1b, 27/96; cervical esophagus/upper thoracic esophagus/middle thoracic esophagus/lower thoracic esophagus, 7/9/66/41 and concurrent chemoradiotherapy/radiotherapy alone, 100/23. Cisplatin and 5-fluorouracil were the most commonly used agents (85%). At the last follow-up (median 60.5 months), 91 (74%) patients were alive. Complete response was achieved in 116 (94.4%) patients. The 5-year overall survival, progression-free survival and local control rates were 77.0, 46.9 and 62.7%, respectively, similar to that in the elderly patients (P = 0.878, 0.754 and 0.648, respectively). There were 55 failures: 42 local, 10 regional and 3 distant failures. Nine local and seven regional failures developed out-of-field. Thirty-eight local failures (90%) were successfully salvaged, of which 30 (71%) were salvaged via endoscopic removal; only 2 regional failures (20%) were salvaged. Fifteen G3 acute toxicities occurred. One pneumonitis (G3), one pneumothorax (G3) and two pericardial effusion (G2) were the late toxicities observed. There were no G4 toxicities or treatment-related deaths.Concurrent chemoradiotherapy without intracavitary brachytherapy was effective and safe for superficial esophageal cancer, even in elderly patients.

    DOI: 10.1093/jjco/hyx021

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  80. Structural MRI correlates of amyotrophic lateral sclerosis progression. Reviewed

    Joe Senda, Naoki Atsuta, Hirohisa Watanabe, Epifanio Bagarinao, Kazunori Imai, Daichi Yokoi, Yuichi Riku, Michihito Masuda, Ryoichi Nakamura, Hazuki Watanabe, Mizuki Ito, Masahisa Katsuno, Shinji Naganawa, Gen Sobue

    J Neurol Neurosurg Psychiatry.   Vol. 88 ( 11 ) page: 901 - 907   2017.5

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  81. Portal Vein Bleeding after Pancreatectomy: Diagnosis and Stent Graft Repair - A Consecutive Case Series. Reviewed

    Kojiro Suzuki, Tomoki Ebata, Tomohiro Komada, Masaya Matsushima, Takashi Mizuno, Tsuyoshi Igami, Gen Sugawara, Yukihiro Yokoyama, Shinji Naganawa, Masato Nagino

    Journal of the Pancreas.   Vol. 18 ( 3 ) page: 241 - 246   2017.5

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  82. Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer Reviewed

    Rise Miyauchi, Yoshiyuki Itoh, Mariko Kawamura, Akihiro Hirakawa, Kiyosumi Shibata, Hiroaki Kajiyama, Rie Nakahara, Seiji Kubota, Junji Ito, Tohru Okada, Fumitaka Kikkawa, Shinji Naganawa

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page: 211 - 220   2017.5

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    The purpose of this retrospective study was to analyze data in patients with stage IB-IIB uterine cervical cancer who were treated with concurrent chemoradiotherapy (CCRT) with high dose cisplatin and fluorouracil as postoperative adjuvant therapy. Between February 2003 and November 2011, 76 patients with FIGO stage IB-IIB cervical cancer were analyzed. Seventy patients were treated with postoperative CCRT and 6 patients were treated with radiation therapy alone. Data related to overall survival (OS), disease-free survival (DFS), toxicity, and failure pattern were analyzed. The median patient age was 45 years (range, 20-80 years). The median follow-up duration was 63 months (range, 10-125 months). Fifty-eight patients (76.3%) had a squamous cell histologic type, 55 patients (72.4%) had lymphovascular invasion, 31 patients (40.8%) had parametrial invasion, and 28 patients (36.8%) had lymph node metastases. Five-year OS and DFS were 96% and 92%, respectively. Five-year DFS in stage IB1 patients was significantly higher than in stage IB2-IIB patients (p = 0.022). Nineteen patients (25%) had grade 3 or 4 neutropenia, 13 patients (17.1%) had grade 3 anemia, and 2 patients (2.6%) had grade 3 thrombocytopenia, but none of these patients died from the disease. Three patients experienced chronic toxicity: one had bladder perforation, one had hydronephrosis, and one experienced ileus. CCRT as postoperative adjuvant therapy resulted in good survival and outcome without severe toxicity.

    DOI: 10.18999/nagjms.79.2.211

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    PubMed

  83. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases Reviewed

    Toshiaki Taoka, Yoshitaka Masutani, Hisashi Kawai, Toshiki Nakane, Kiwamu Matsuoka, Fumihiko Yasuno, Toshifumi Kishimoto, Shinji Naganawa

    JAPANESE JOURNAL OF RADIOLOGY   Vol. 35 ( 4 ) page: 172 - 178   2017.4

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    Purpose The activity of the glymphatic system is impaired in animal models of Alzheimer's disease (AD). We evaluated the activity of the human glymphatic system in cases of AD with a diffusion-based technique called diffusion tensor image analysis along the perivascular space (DTI-ALPS).
    Materials and methods Diffusion tensor images were acquired to calculate diffusivities in the x, y, and z axes of the plane of the lateral ventricle body in 31 patients. We evaluated the diffusivity along the perivascular spaces as well as projection fibers and association fibers separately, to acquire an index for diffusivity along the perivascular space (ALPS-index) and correlated them with the mini mental state examinations (MMSE) score.
    Results We found a significant negative correlation between diffusivity along the projection fibers and association fibers. We also observed a significant positive correlation between diffusivity along perivascular spaces shown as ALPS-index and the MMSE score, indicating lower water diffusivity along the perivascular space in relation to AD severity.
    Conclusion Activity of the glymphatic system may be evaluated with diffusion images. Lower diffusivity along the perivascular space on DTI-APLS seems to reflect impairment of the glymphatic system. This method may be useful for evaluating the activity of the glymphatic system.

    DOI: 10.1007/s11604-017-0617-z

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    PubMed

  84. Lack of Contrast Enhancement in a Giant Perivascular Space of the Basal Ganglion on Delayed FLAIR Images: Implications for the Glymphatic System. Reviewed

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka

    Magn Reson Med Sci.   Vol. 16 ( 2 ) page: 89 - 90   2017.4

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    DOI: 10.2463/mrms.ci.2016-0114

  85. Magnetic resonance imaging evaluation of endolymphatic hydrops andpost-operative findings in cases with otosclerosis Reviewed

    Michihiko Sone, Tadao Yoshida, Satofumi Sugimoto, Kyoko Morimoto, Yuriko Okazaki, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima

    ACTA OTO-LARYNGOLOGICA   Vol. 137 ( 3 ) page: 242 - 245   2017.3

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    Conclusions: The presence of endolymphatic hydrops (EH) in the vestibule on magnetic resonance imaging (MRI) might be a high-risk factor for complications in cases that are candidates for stapes surgery.
    Objective: Pre-operative detection of EH could be valuable in cases that are candidates for stapes surgery to prevent unpredictable complications following surgery. Pre-operative MRI findings and post-operative findings following stapes surgery were compared to evaluate the efficacy of such MRI evaluation for the management of cases with otosclerosis.
    Subjects and methods: Sixteen cases who underwent pre-operative evaluation by 3T MRI performed 4h after intravenous injection of gadolinium and stapes surgery for otosclerosis were recruited. Imaging data concerning the degree of EH in the vestibule and cochlea were compared with post-operative clinical findings for all cases.
    Results: Mild EH in the cochlea or the vestibule was observed in eight ears and one ear, respectively, whereas one ear showed significant EH both in the cochlea and the vestibule. The post-operative course was uneventful in 12 of 14 cases with no EH in the vestibule, and the other two cases had a short period of dizziness, but two cases with EH in the vestibule had a long period of dizziness.

    DOI: 10.1080/00016489.2016.1232862

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    PubMed

  86. Emerging neuroradiological topics in journals from related societies. Reviewed

    Yukunori Korogi, Shinji Naganawa

    Jpn. J Radiol.   Vol. 35 ( 1 ) page: 1 - 2   2017.2

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  87. Imaging of the endolymphatic space in patients with Ménière's disease. Reviewed

    Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Hironao Otake, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

    Auris Nasus Larynx.   Vol. 45 ( 1 ) page: 33 - 38   2017.2

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  88. Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer. Reviewed

    Rise Miyauchi, Yoshiyuki Itoh, Mariko Kawamura, Akihiro Hirakawa, Kiyosumi Shibata, Hiroaki Kajiyama, Rie Nakahara, Seiji Kubota, Junji Ito, Tohru Okada, Fumitaka Kikkawa, Shinji Naganawa

    Nagoya J Med Sci.   Vol. 79 ( 2 ) page: 211 - 220   2017.2

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  89. Emerging neuroradiological topics in journals from related societies Reviewed

    Yukunori Korogi, Shinji Naganawa

    JAPANESE JOURNAL OF RADIOLOGY   Vol. 35 ( 1 ) page: 1 - 2   2017.1

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    DOI: 10.1007/s11604-016-0600-0

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    PubMed

  90. Endolymphatic hydrops in patients with unilateral and bilateral Meniere's disease Reviewed

    Kyoko Morimoto, Tadao Yoshida, Saiko Sugiura, Masahiro Kato, Ken Kato, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

    ACTA OTO-LARYNGOLOGICA   Vol. 137 ( 1 ) page: 23 - 28   2017.1

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    Conclusion: All definite Meniere's disease (MD) had endolymphatic hydrops (EH) at least in the cochlea or the vestibule. Symptoms of MD may appear after formation of EH. It is assumed that the probability of immediate progression to bilateral MD from unilateral MD is very low in patients without EH on the non-affected side.
    Objective: To evaluate the EH on both sides in patients with unilateral and bilateral MD, and to investigate factors with progression to bilateral MD including the degree of EH, hearing level, and the duration of MD.
    Patients and methods: The study included 29 patients with unilateral definite MD and 12 patients with bilateral definite MD. The endolymphatic space size was visualized by using 3-Tesla magnetic resonance imaging.
    Results: All patients with unilateral and bilateral MD had significant or mild EH at least in the cochlea or the vestibule on the affected side. On the non-affected side, EH was not observed at all in eight patients, but asymptomatic EH was observed in the cochlea in 14 patients and in the vestibule in 16 patients. There was no relationship between the EH on the non-affected side and the duration of MD.

    DOI: 10.1080/00016489.2016.1217042

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  91. Thoracic Temporal Subtraction Three Dimensional Computed Tomography (3D-CT): Screening for Vertebral Metastases of Primary Lung Cancers Reviewed

    Shingo Iwano, Rintaro Ito, Hiroyasu Umakoshi, Takatoshi Karino, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    PLOS ONE   Vol. 12 ( 1 ) page: e0170309   2017.1

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    Purpose
    We developed an original, computer-aided diagnosis (CAD) software that subtracts the initial thoracic vertebral three-dimensional computed tomography (3D-CT) image from the follow-up 3D-CT image. The aim of this study was to investigate the efficacy of this CAD software during screening for vertebral metastases on follow-up CT images of primary lung cancer patients.
    Materials and Methods
    The interpretation experiment included 30 sets of follow-up CT scans in primary lung cancer patients and was performed by two readers (readers A and B), who each had 2.5 years' experience reading CT images. In 395 vertebrae from C6 to L3, 46 vertebral metastases were identified as follows: osteolytic metastases (n = 17), osteoblastic metastases (n = 14), combined osteolytic and osteoblastic metastases (n = 6), and pathological fractures (n = 9). Thirty-six lesions were in the anterior component (vertebral body), and 10 lesions were in the posterior component (vertebral arch, transverse process, and spinous process). The area under the curve (AUC) by receiver operating characteristic (ROC) curve analysis and the sensitivity and specificity for detecting vertebral metastases were compared with and without CAD for each observer.
    Results
    Reader A detected 47 abnormalities on CT images without CAD, and 33 of them were true-positive metastatic lesions. Using CAD, reader A detected 57 abnormalities, and 38 were true positives. The sensitivity increased from 0.717 to 0.826, and on ROC curve analysis, AUC with CAD was significantly higher than that without CAD (0.849 vs. 0.902, p = 0.021). Reader B detected 40 abnormalities on CT images without CAD, and 36 of them were true-positive metastatic lesions. Using CAD, reader B detected 44 abnormalities, and 39 were true positives. The sensitivity increased from 0.783 to 0.848, and AUC with CAD was non-significantly higher than that without CAD (0.889 vs. 0.910, p = 0.341). Both readers detected more osteolytic and osteoblastic metastases with CAD than without CAD.
    Conclusion
    Our temporal 3D-CT subtraction CAD software easily detected vertebral metastases on the follow-up CT images of lung cancer patients regardless of the osteolytic or osteoblastic nature of the lesions.

    DOI: 10.1371/journal.pone.0170309

    Web of Science

  92. Structure of the Medullary Veins of the Cerebral Hemisphere and Related Disorders Reviewed

    Toshiaki Taoka, Akio Fukusumi, Toshiteru Miyasaka, Hisashi Kawai, Toshiki Nakane, Kimihiko Kichikawa, Shinji Naganawa

    RADIOGRAPHICS   Vol. 37 ( 1 ) page: 280 - 296   2017.1

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    Deep medullary veins drain into subependymal veins with four convergence zones and show parallel distribution patterns adjacent to the body or inferior horn and a radial pattern in the frontal horn or trigon of the lateral ventricle. As white matter imaging develops such as diffusion tensor imaging or susceptibility-weighted imaging, requirements for understanding of white matter structures are increasing, not only for understanding of neuronal tracts but also for that of other structures including the fine anatomy of white matter vessels. Some disorders are related to deep medullary veins and show characteristic distributions of the lesions indicating the relationship to the medullary veins. When lesions show a parallel or radial distribution pattern in the certebral deep white matter, disorders related to deep medullary veins should be considered for differential diagnosis. In this review, we discuss disorders related to deep medullary veins, including (a) anomalies of the medullary veins, (b) hemorrhagic disorders related to the medullary veins (diffuse vascular injury due to high-energy trauma, deep medullary vein engorgement/thrombosis in neonates), (c) inflammatory changes that spread along the medullary veins, (d) neoplasms within the medullary veins, and (e) metabolic changes that lead to altered visualization of medullary veins. Understanding the anatomic structure of medullary veins in the cerebral hemisphere and becoming familiar with disorders in which the medullary veins play a major role in disease development may be helpful in the interpretation of brain images. (C) RSNA, 2017

    DOI: 10.1148/rg.2017160061

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    PubMed

  93. 脈絡膜悪性黒色腫の診断におけるIMP SPECT,FDG PET/CT,FDOPA PET/CTの比較 Reviewed

    加藤克彦, 小田川哲郎, 阿部真治, 山口博司, 伊藤倫太郎, 伊藤信嗣, 岩野信吾, 長縄慎二

    核医学(Web)   Vol. 54 ( Supplement )   2017

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    J-GLOBAL

  94. 胸壁並行断面CTを用いた間質性肺炎の定量的評価 Reviewed

    馬越弘泰, 岩野信吾, 伊藤倫太郎, 長縄慎二

    Japanese Journal of Radiology   Vol. 35 ( Supplement )   2017

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    J-GLOBAL

  95. PET/CTは小型肺癌のTNM分類に基づく術後予後予測を補助する Reviewed

    岩野信吾, 馬越弘泰, 伊藤倫太郎, 伊藤信嗣, 川口晃司, 福井高幸, 横井香平, 加藤克彦, 長縄慎二

    核医学(Web)   Vol. 54 ( Supplement )   2017

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    J-GLOBAL

  96. Dual Energy CTによる小型肺癌の造影評価 Reviewed

    島本宏矩, 岩野信吾, 馬越弘泰, 伊藤倫太郎, 長縄慎二

    Japanese Journal of Radiology   Vol. 35 ( Supplement )   2017

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    J-GLOBAL

  97. Glymphatic system評価に向けて:DTI analysis along Perivascular Space(DTI-ALPS)でのAlzheimer病例の検討 Reviewed

    田岡俊昭, 増谷佳孝, 川井恒, 中根俊樹, 長縄慎二

    日本神経放射線学会プログラム・抄録集   Vol. 46th   2017

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    J-GLOBAL

▼display all

Presentations 913

  1. メニエール病の画像診断:小さな宇宙を究める、内リンパ水腫のその先に Invited

    長縄慎二

    第20回 Radiology Update in Gifu  2024.10.11  第20回 Radiology Update in Gifu

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    Event date: 2024.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:岐阜   Country:Japan  

  2. メニエール病の画像診断;小さな宇宙を究める

    長縄慎二

    第34回日本耳科学会総会・学術講演会  2024.10.4  第34回日本耳科学会総会・学術講演会

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    Event date: 2024.10

    Presentation type:Oral presentation (invited, special)  

    Venue:名古屋   Country:Japan  

  3. Endolymphatic Hydrops (EH) Imaging with Single-Dose IV Gadolinium Invited International conference

    Shinji Naganawa

    Barany Society Meeting 2024  2024.8.26  Barany Society

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    Event date: 2024.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Uppsala, Sweden   Country:Sweden  

  4. MR imaging of the glymphatic system with IV-GBCA Invited International conference

    Shinji Naganawa

    LUND GLYMPHATIC SYMPOSIUM  2024.6.18  LUND GLYMPHATIC SYMPOSIUM

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    Event date: 2024.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Lund, Sweden   Country:Sweden  

  5. 講演1,2の座長 International conference

    2024.5.6 

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    Event date: 2024.5

    Language:English  

    Country:Singapore  

  6. MR Imaging of Intrapympanically Administered 17O Labeled Water in the Human Inner Ear: Insight into Lymphatic Dynamics and Vestibular Function Invited International conference

    Shinji Naganawa

    17O Labeled Stable Isotope Water Imaging Symposium  2024.3.9 

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    Event date: 2024.3

    Country:Japan  

  7. Shinji Naganawa

    Shinji Naganawa

    ECR 2024  2024.3.1 

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    Event date: 2024.2 - 2024.3

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Vienna, Austria   Country:Austria  

  8. MR Imaging for Endolymphatic Hydrops Invited International conference

    Shinji Naganawa

    Radiological Society of North America (RSNA) 109th Scientific Assembly and Annual Meeting  2023.11 

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    Event date: 2023.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Chicago, USA   Country:United States  

  9. MR imaging of endolymphatic hydrops in Meniere’s disease : What neuroradiologists should know International conference

    Shinji Naganawa

    The 14th Asian-Oceanian Congress of Neuroradiology (AOCNR 2023)  2023.8 

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    Event date: 2023.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Singapore   Country:Singapore  

  10. Hemodynamic changes in liver transplant donors after surgery: analysis with 4D flow MRI International conference

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yasuhiro Ogura, Shinji Naganawa

    European Congress of Radiology (ECR) 2023 

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    Event date: 2023.3

    Language:English   Presentation type:Poster presentation  

    Venue:Vienna, Austria   Country:Austria  

  11. How Should Radiologists USA AI To Fight COVID-19 Pneumonia? International conference

    Rintaro Ito, Shingo Iwano, Shinji Naganawa

    Radiological Society of North America Annual Meeting 2021 (RSNA 2021)  Radiological Society of North America Annual Meeting 2021 (RSNA 2021)

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    Event date: 2021.11 - 2021.12

    Language:English   Presentation type:Poster presentation  

    Venue:Chicago, Illinois, USA/onsite   Country:United States  

  12. 基調講演:人工知能とこれからの放射線医学 Invited

    長縄慎二

    遠隔画像診断 講演会 人工知能と最新画像診断地域医療に貢献する遠隔画像診断  2024.10.26 

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    Event date: 2024.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋   Country:Japan  

  13. 特別講演 Ⅰ、Ⅱの座長

    長縄慎二

    名古屋先端量子医学フォーラム2024  2024.10.25  名古屋先端量子医学フォーラム2024

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    Event date: 2024.10

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  14. <指名講演Ⅰ>の座長

    長縄慎二

    第15回 心腎画像研究会 (WEB)   2024.10.10  第15回 心腎画像研究会

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    Event date: 2024.10

    Language:Japanese  

    Venue:Web開催   Country:Japan  

  15. 睡眠時無呼吸症候群症例での睡眠および呼吸関連パラメータとMRIによる脳間質液動態関連パラメータの評価

    田岡俊昭、伊藤倫太郎、中道玲瑛、中根俊樹、岩本邦弘、宮田聖子、安藤元郎、藤城弘樹、池田匡志、長縄慎二

    JSMRM2024 第52回日本磁気共鳴医学会大会  JSMRM2024 第52回日本磁気共鳴医学会大会

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    Event date: 2024.9

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:千葉   Country:Japan  

  16. 点眼による硝子体腔への薬剤分布の可視化:豚眼を用いたultra-heavily T2 強調画像での検討

    加藤 裕、結城賢弥、西口康二、長縄慎二

    JSMRM2024 第52回日本磁気共鳴医学会大会  JSMRM2024 第52回日本磁気共鳴医学会大会

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    Event date: 2024.9

    Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  17. 乳房拡散協調画像における脂肪抑制法 (STIR vs SPAIR) の比較:病変と乳房組織の定性的および定量的解析

    飯間麻美、片岡正子、大橋 茜、山口 健、井上 依里香、徳田由紀子、本田茉也、佐竹弘子、久保田一徳、藤岡友之、ルビアン デニス、長縄慎二、中本裕士

    JSMRM2024 第52回日本磁気共鳴医学会大会  JSMRM2024 第52回日本磁気共鳴医学会大会

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    Event date: 2024.9

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:千葉   Country:Japan  

  18. MR imaging of the glymphatic system with IV-GBCA

    長縄慎二

    京都髄液フォーラム2024  2024.8.4  京都髄液フォーラム2024

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    Event date: 2024.8

    Language:Japanese  

    Venue:京都   Country:Japan  

  19. 特別講演1,2の座長

    長縄慎二

    第32回名古屋放射線夏季セミナー  2024.7.20  第32回名古屋放射線夏季セミナー

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    Event date: 2024.7

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  20. MRIによる脳クリアランスシステムの評価の座長 Invited

    長縄慎二

    JCRミッドサマーセミナー2024   2024.7.14  JCRミッドサマーセミナー2024 

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    Event date: 2024.7

    Language:Japanese  

    Venue:浜松   Country:Japan  

  21. 腎癌の胸椎浸潤を伴う肋骨転移に対し定位放射線治療およびカボザンチニブ投与後に食道穿孔を生じた症例

    奥村真之、石原俊一、川村麻里子、大家祐実、香西由加、山田剛大、長井尚哉、青木すみれ、安井遼太郎、向原岳志、長縄慎二 佐野友康、赤松秀輔

    日本医学放射線学会 第175回中部地方会  日本医学放射線学会 第175回中部地方会

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    Event date: 2024.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  22. 心臓弁置換術後の難治性鼠径部リンパ漏に対しリンパ管塞栓術を施行した1例

    玉城大希、松島正哉、伊藤大智、浅井遼太、佐藤雄基、堀口瞭太、兵藤良太、長坂 憲、駒田智大、岩野信吾、長縄慎二、徳田順之

    第74回 中部IVR研究会  第74回 中部IVR研究会

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    Event date: 2024.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  23. 当院におけるⅢ期非小細胞肺癌の根治的放射線治療の成績

    青木すみれ、奥村真之、石原俊一、川村麻里子、大家祐実、香西由加、山田剛大、長井尚哉、安井遼太郎、向原岳志、長縄慎二 森瀬昌宏、長谷哲成、田中一大

    日本医学放射線学会 第175回中部地方会  日本医学放射線学会 第175回中部地方会

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    Event date: 2024.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  24. 腎癌膵転移との区別が困難であった膵パチニ小体の1例

    小川 浩、竹原康雄、長縄慎二、高見秀樹、中黒匡人

    第37回日本腹部放射線学会  第37回日本腹部放射線学会

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    Event date: 2024.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:埼玉、川越   Country:Japan  

  25. 虫垂の神経線維腫症の一例

    東 真理奈、石垣聡子、神谷晋一朗、阿部有美、村田悠記、長縄慎二

    第37回日本腹部放射線学会  第37回日本腹部放射線学会

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    Event date: 2024.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:埼玉、川越   Country:Japan  

  26. 特別企画4 (JJRセミナー) (領域講習:診断・治療) 「最新AIがもたらす医学論文執筆と査読の超進化」 の座長

    長縄慎二

    第83回日本医学放射線学会総会  2024.4.14  第83回日本医学放射線学会総会

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    Event date: 2024.4

    Language:Japanese  

    Venue:横浜   Country:Japan  

  27. Pioneering in Ultra Strong Gradient Conferenceの座長

    長縄慎二

    第83回日本医学放射線学会総会  2024.4.12  第83回日本医学放射線学会総会

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    Event date: 2024.4

    Language:Japanese  

    Venue:横浜   Country:Japan  

  28. 特別講演2 座長

    長縄慎二

    第25回放射線研究セミナー  2024.4.6  第25回放射線研究セミナー

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    Event date: 2024.4

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  29. 特別講演 Ⅰ - Safety -の座長

    長縄慎二

    レケンビ適正使用講演会 in 愛知  2024.3.27 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:ハイブリッド開催 名古屋/オンライン   Country:Japan  

  30. 腎癌膵転移との区別が困難であった膵パチニ小体の1例

    小川 浩、竹原康雄、 長縄慎二、高見秀樹、中黒匡人

    日本医学放射線学会 第174回中部地方会 

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    Event date: 2024.2

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  31. 術前に造影CTで診断し得た肺葉外肺分画症捻転の症例

    東 真理奈、駒田智大、中根俊樹、 岩野信吾、長縄慎二、合田 陽祐、下山芳江、古池 亘

    日本医学放射線学会 第174回中部地方会 

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    Event date: 2024.2

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  32. 頭部MRIの所見抽出におけるLarge Language Modelの活用について

    加藤恵太、長縄慎二、伊藤倫太郎、田岡俊昭

    日本医学放射線学会 第174回中部地方会 

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    Event date: 2024.2

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  33. 巨大肝内門脈肝静脈シャントをcoil-in plug法で安全に塞栓できた一例

    堀口瞭太、兵藤良太、竹原康雄、長坂 憲、玉城大希、 佐藤雄基、 松島正哉、駒田智大、長縄慎二、水野 崇、 市川和茂、犬飼庸介、石津洋二

    日本医学放射線学会 第174回中部地方会 

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    Event date: 2024.2

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  34. 前立腺癌に対するスペーサーゲル留置下での定位照射後に直腸穿孔を生じた一例

    柳 裕介、山田剛大、 大家祐実、 香西由加、 奥村真之、 青木すみれ、 安井遼太郎、 川村麻里子、 石原俊一、長縄慎二、石田昇平、 澤田つな騎

    日本医学放射線学会 第174回中部地方会 

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    Event date: 2024.2

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  35. 不眠症症例でのオレキシン受容体拮抗薬投与によるALPS-indexへの影響

    田岡俊昭、伊藤倫太郎、岩本邦弘、宮田聖子、藤本明浩、市之瀬伸保、鎌形康司、青木茂樹、尾崎紀夫、長縄慎二

    第53回日本神経放射線学会 

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    Event date: 2024.2

    Language:Japanese  

    Venue:埼玉   Country:Japan  

  36. ランチョンセミナー1での座長

    長縄慎二

    第53回日本神経放射線学会  2024.2.9  第53回日本神経放射線学会

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    Event date: 2024.2

    Language:Japanese  

    Venue:埼玉   Country:Japan  

  37. ISMRM Workshopについて

    長縄慎二

    日本磁気共鳴医学会 「Neurofluidスタディグループ」 第4回meeting  2023.12.16 

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    Event date: 2023.12

    Venue:Web開催  

  38. がん検診の画像診断 (AI診断を含む)

    長縄慎二

    愛知県医師会「現代医学」誌70巻号の特集テーマ「がん検診」座談会   2023.11.6 

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    Event date: 2023.11

    Language:Japanese  

    Venue:名古屋  

  39. 高橋信次先生の研究と断層映像研究会

    長縄慎二

    第51回断層映像研究会  2023.10.6  第51回断層映像研究会

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:名古屋  

  40. Perspective from Editor-in-Chief of JJR

    長縄慎二

    第51回日本磁気共鳴医学会大会   2023.9 

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    Event date: 2023.9

    Language:Japanese  

    Venue:軽井沢  

  41. Intravenous Gadolinium Based Imaging Invited International conference

    Shinji Naganawa

    ISMRM Workshop on Neurofluids: Anatomy, Physiology & Imaging 

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    Event date: 2022.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:ハイブリッド開催 Rome, Italy/Online  

  42. Panel Discussion: Opportunities & Challenges of MRI for Brain Clearance Imaging Invited International conference

    Shinji Naganawa

    ISMRM Workshop on Neurofluids: Anatomy, Physiology & Imaging 

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    Event date: 2022.9

    Language:English  

    Venue:ハイブリッド開催 Rome, Italy/Online  

  43. Glymphatic system; what radiologists should know now Invited

    Shinji Naganawa

    AOCR 2022 & KCR 2022 (The 20th Asian Oceanian Congress of Radiology, The 78th Annual Meeting of the Korean Society of Radiology) 

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    Event date: 2022.9

    Language:English  

    Venue:ハイブリッド開催 / Coex, Seoul, Korea   Country:Korea, Republic of  

  44. Portal blood flow in the remnant portal branches is increased after percutaneous transhepatic portal vein embolization (PTPVE) for biliary tract cancer: an analysis with 4D flow MRI International conference

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazusige Ichikawa, Masataka Sugiyama, Tomoki Ebata, Shinji Naganwa

    ESGAR 2022 (European Society of Gastrointestinal and Abdominal Radiology) 

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    Event date: 2022.5 - 2022.6

    Language:English   Presentation type:Poster presentation  

    Venue:Lisbon, Portugal  

  45. A Flowmetry Study Of Superior Mesenteric Artery Using 4D-Flow MRI; Efficient Blood Delivery To The Superior Mesenteric Artery Might Be Reduced In Abdominal Aortic Aneurysm Patients Compared To The Controls With Non-dilated Abdominal Aorta. International conference

    Masataka Sugiyama, Yasuo Takehara, Takasuke Ushio, Tetsuya Wakayama, Atsushi Nozaki, Satoshi Goshima, Shinji Naganawa

    ESGAR 2022 (European Society of Gastrointestinal and Abdominal Radiology) 

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    Event date: 2022.5 - 2022.6

    Language:English   Presentation type:Poster presentation  

    Venue:Lisbon, Portugal  

  46. PMRT without bolus is feasible

    Yurika Shindo, Mariko Kawamura, Masayuki Okumura, Syunichi Ishihara, Yumi Oie, Yuki Takase, Naoya Nagai, Sumire Aoki, Ryotaro Yasui, Shinji Naganawa

    Global Breast Cancer Conference 2022 

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    Event date: 2022.4

    Language:English   Presentation type:Poster presentation  

    Venue:Seoul, Korea/Web   Country:Korea, Republic of  

  47. Intravenous Gadolinium Imaging Invited International conference

    Shinji Naganawa

    ISMRM Imaging Neurofluids Study Group Virtual Meeting, Part 2. (Post-Gadolinium Imaging & Brain Waste Clearance) 

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    Event date: 2021.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  48. Neurofluid Imaging and Glymphatic System (基調講演 座長) International conference

    Shinji Naganawa

    AIMS Neuro Imaging 2021 On the web (ZOOM Webinar) 

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    Event date: 2021.10

    Presentation type:Oral presentation (invited, special)  

  49. Inversion Recovery Sequences & Gadolinium パネリスト Invited International conference

    Shinji Naganawa

    ISMRM Imaging Neurofluids Study Group Virtual Meeting (Inversion Recovery Sequences & Gadolinium) 

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    Event date: 2021.10

    Language:English   Presentation type:Oral presentation (invited, special)  

  50. Study of CSF dynamics using GBCAs Invited International conference

    Shinji Naganawa

    Frontiers of Neuroimaging Symposium (FON) 2021  2021.10.23 

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    Event date: 2021.10

    Language:English   Presentation type:Oral presentation (invited, special)  

  51. 臨床MRI安全運用のための指針に基づく造影剤使用の安全管理と造影剤に関わる最近の話題

    長縄慎二

    第30回講演会「MRI安全性の考え方」 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:Web開催   

  52. Glymphatic system仮説の概説

    長縄慎二

    第49回日本磁気共鳴医学会大会 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:ハイブリッド開催  

  53. 研究から論文発表までの戦略;私のトリプルスリーとトリプルS

    長縄慎二

    第49回日本磁気共鳴医学会大会 

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    Event date: 2021.9

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:ハイブリッド開催  

  54. Can we safely lower the RT dose with the use of high dose PF for advanced cervical cancer? International conference

    Mariko Kawamura, Rie Nakahara, Shunichi Ishihara, Yumi Oie, Yuki Takase, Masayuki Okumura, Junji Ito, Tamami Ono, Yoshiyuki Itoh, Shinji Naganawa

    The European Society for Radiotherapy and Oncology (ESTRO) 2021 

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    Event date: 2021.8

    Language:English   Presentation type:Poster presentation  

  55. 臨床MRI安全運用のための指針に基づく造影剤使用の安全管理と造影剤に関わる最近の話題

    長縄慎二

    第29回講習会 「MRI安全性の考え方」 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:Web開催   

  56. Glymphatic system仮説とガドリニウム造影剤

    長縄慎二

    第30回日本定位放射線治療学会 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Web開催   

  57. 臨床MRI安全運用のための指針に基づく造影剤使用の安全管理と造影剤に関わる最近の話題

    長縄慎二

    第28回講習会「MRI安全性の考え方」 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:Web開催   

  58. Imaging for CSF and Glymphatic Disorders: Where We Are Now

    Shinji Naganawa

    AOCNR 2021 (The 13th Asian-Oceanian Congress of Neuroradiology) 

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    Event date: 2021.4

    Language:English  

    Country:Japan  

  59. 中枢神経領域での画像診断 おさえておくべきポイント

    長縄慎二

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    Event date: 2021.4

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Web開催   

  60. Towards the visualization of Neurofluids dynamics by MR using IV-GBCA Invited International conference

    Shinji Naganawa

    NEUROFLUIDS: Physiology, methods and disease 

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    Event date: 2021.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  61. Glymphatic system仮説とガドリニウム造影剤:変わりつつある常識

    長縄慎二

    エーザイ造影剤インターネットライブセミナー 

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    Event date: 2021.3

    Language:Japanese  

    Venue:Web開催   

  62. 膵頭十二指腸切除後の門脈出血に対しVIABAHNで治療した1例

    伊藤 準、松島正哉、山田恵一郎、堀口瞭太、兵藤良太、駒田智大、長縄慎二

    第67回中部・第68回関西INTERVENTIONAL RADIOLOGY研究会 

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    Event date: 2021.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web開催   

  63. ALPS methos

    菊田潤子、鎌形康司、高林海斗、染谷由希、田村好史、河盛隆造、錦田裕孝、田岡俊昭、長縄慎二、青木茂樹

    第50回日本神経放射線学会 

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    Event date: 2021.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:Web開催   

  64. Water Peak MRS:組織中の溶媒の評価の試み

    田岡俊昭、伊藤倫太郎、阿部考志、中道玲瑛、中根俊樹、川井 恒、長縄慎二

    第50回日本神経放射線学会 

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    Event date: 2021.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web開催   

  65. そろそろ知らないと恥ずかしい内リンパ水腫画像

    長縄慎二

    Radiology Today in Setouchi 7th Theme:神経の画像診断 

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    Event date: 2021.1

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:Web開催   

  66. 中枢神経領域での画像診断 おさえておくべきポイント

    長縄慎二

    第24回MR実践講座 共催セミナー 

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    Event date: 2020.12

    Language:Japanese   Presentation type:Oral presentation (keynote)  

    Venue:Web開催   

  67. 家族性大腸腺腫症に随伴した多発甲状腺癌の一例

    小木曾由梨、佐竹弘子、石垣聡子、長縄慎二

    第33回頭頸部放射線研究会 

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    Event date: 2020.10 - 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web開催   

  68. Glymphatic system and Gd-based contrast agent International conference

    Shinji Naganawa

    AIMS Neuro Imaging 2020 

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    Event date: 2020.10

    Language:English   Presentation type:Poster presentation  

    Venue:Web  

  69. 5〜10個の脳転移に対するCyberknife治療における単一計画での同時照射法の有用性

    大宝和博、熊谷始紀、髙瀬裕樹、伊藤淳二、棚橋邦明、大岡史治、加茂前健、伊藤善之、長縄慎二

    日本放射線腫瘍学会第33回学術大会 

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    Event date: 2020.10

    Language:Japanese  

    Venue:Web開催   

  70. 7T-MRI装置におけるMP2RAGEを用いた視床内部構造の描出

    中根俊樹、福永雅喜、田岡俊昭、川井 恒、加藤 裕、櫻井康雄、長縄慎二

    第48回日本磁気共鳴医学会大会 

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    Event date: 2020.9 - 2020.10

    Presentation type:Oral presentation (general)  

    Venue:Web開催   

  71. AiCE併用T2強調像でのNigrosome描出のための至適エコー時間・再構成の検討

    田岡俊昭、川井 恒、中根俊樹、伊藤倫太郎、中道玲瑛、市川和茂、酒井黛呼、長縄慎二

    第48回日本磁気共鳴医学会大会 

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    Event date: 2020.9 - 2020.10

    Venue:Web開催   

  72. Multi b-value Diffusion weighted image Diphase Map (MbDDM) to evaluate cerebrospinal fluid dynamics. International conference

    Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Toshiki Nakane, Hisashi Kawai, Shinji Naganawa

    ISMRM & SMRT Virtual Conference & Exhibition 

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    Event date: 2020.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Web  

  73. EVAR Does Not Affect Mean Blood Flow Volume and Flow Profile of the Visceral Arteries. International conference

    Masataka Sugiyama, Yasuo Takehara, Ryota Horiguchi, Takashi Mizuno, Ryota Hyodo, Takasuke Ushio, Tetsuya Wakayama, Atsushi Nozaki, Hiroyuki Kabasawa, Marcus Alley, Satoshi Goshima, Shinji Naganawa

    ISMRM & SMRT Virtual Conference & Exhibition 

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    Event date: 2020.8

    Language:English   Presentation type:Poster presentation  

    Venue:Web  

  74. Energy loss assessed with 4D-Flow for the normal subjects and patients with an abdominal aortic aneurysm pre and post endovascular aortic repair. International conference

    Takashi Mizuno, Yasuo Takehara, Masataka Sugiyama, Ryota Horiguchi, Shinji Naganawa, Yasuo Sakurai, Yutaka Kato, Shinji Abe, Haruo Isoda, Tomohiro Sato, Tsuneo Ishiguchi, Masanori Tadokoro, Atsushi Nozaki

    ISMRM & SMRT Virtual Conference & Exhibition 

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    Event date: 2020.8

    Language:English   Presentation type:Poster presentation  

    Venue:Web  

  75. Multi b-value Diffusion weighted image Diphase Map (MbDDM) to evaluate cerebrospinal fluid dynamics. International conference

    Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Toshiki Nakane, Hisashi Kawai, Shinji Naganawa

    ISMRM & SMRT Virtual Conference & Exhibition 

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    Event date: 2020.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Web  

  76. EVAR Does Not Affect Mean Blood Flow Volume and Flow Profile of the Visceral Arteries. International conference

    Masataka Sugiyama, Yasuo Takehara, Ryota Horiguchi, Takashi Mizuno, Ryota Hyodo, Takasuke Ushio, Tetsuya Wakayama, Atsushi Nozaki, Hiroyuki Kabasawa, Marcus Alley, Satoshi Goshima, Shinji Naganawa

    ISMRM & SMRT Virtual Conference & Exhibition 

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    Event date: 2020.8

    Language:English   Presentation type:Poster presentation  

    Venue:Web  

  77. Energy loss assessed with 4D-Flow for the normal subjects and patients with an abdominal aortic aneurysm pre and post endovascular aortic repair. International conference

    Takashi Mizuno, Yasuo Takehara, Masataka Sugiyama, Ryota Horiguchi, Shinji Naganawa, Yasuo Sakurai, Yutaka Kato, Shinji Abe, Haruo Isoda, Tomohiro Sato, Tsuneo Ishiguchi, Masanori Tadokoro, Atsushi Nozaki

    ISMRM & SMRT Virtual Conference & Exhibition 

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    Event date: 2020.8

    Language:English   Presentation type:Poster presentation  

    Venue:Web  

  78. Quantitative evaluation of distortion in magnetic resonance imaging for radiation treatment planning: Characterization of system-related geometric distortion and effectiveness of distortion correction International conference

    Yutaka Kato, Kuniyasu Okudaira, Motoki kumagai, Toshiaki Taoka, Takeshi Kamomae, Yoshiyuki Itoh, Shinji Naganawa

    European Congress of Radiology (ECR) 2020 

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    Event date: 2020.7

    Language:English   Presentation type:Poster presentation  

    Venue:Online   Country:Japan  

  79. Multi b-value Diffusion weighted image Diphase Map (MbDDM) による脳脊髄液動態の評価

    田岡俊昭、伊藤倫太郎、中道玲瑛、中根俊樹、川井 恒、長縄慎二

    第49回日本神経放射線学会 

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    Event date: 2020.6

    Presentation type:Oral presentation (general)  

    Venue:Web開催   

  80. b値拡散強調画像から見た正常圧水頭症の脳脊髄液

    中根俊樹、田岡俊昭、長縄慎二

    第49回日本神経放射線学会 

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    Event date: 2020.6

    Venue:Web開催   

  81. A case of hepatic vein embolization in addition to portal vein embolization for hepatectomy

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    Event date: 2020.5

    Language:Japanese   Presentation type:Poster presentation  

  82. 【シンポジウム25】JJRセミナー『あらためて学ぶ査読のコツ』

    長縄慎二

    第79回日本医学放射線学会総会 

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    Event date: 2020.5 - 2020.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:Web 「Cypos」やオンデマンド配信  

  83. 【Web特別企画3】 臨床MRI安全運用のための指針に基づく造影剤使用の安全管理と造影剤に関わる最近の話題

    長縄慎二

    第79回日本医学放射線学会総会 

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    Event date: 2020.5 - 2020.6

    Venue:Web 「Cypos」やオンデマンド配信  

  84. 【特別企画2】気持ちが伝わるプレゼンテーション

    長縄慎二

    第79回日本医学放射線学会総会 

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    Event date: 2020.5 - 2020.6

    Language:Japanese  

    Venue:Web 「Cypos」やオンデマンド配信  

  85. IGBT導入に向けたコンツール制度の検証: high volume centerでの導入に向けて

    川村麻里子、伊藤善之、大宝和博、伊藤淳二、中原理絵、大家祐実、香西由加、髙瀬裕樹、加茂前健、長縄慎二

    日本医学放射線学会第167回中部地方会 

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    Event date: 2020.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋  

  86. 乳房専用PETにおける正常乳腺のFDG集積に対する閉経の有無と月経周期の影響

    清水友理、佐竹弘子、石垣聡子、長縄慎二、田所匡典、石口恒男

    日本医学放射線学会第167回中部地方会 

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    Event date: 2020.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋  

  87. 肝原発MALTリンパ腫の2例

    西田あゆみ、兵藤良太、岩野信吾、下山芳江、長縄慎二

    第87回東海総合画像医学研究会 

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    Event date: 2020.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋  

  88. 特別講演 Glymphatic SystemとMRI Invited

    長縄慎二

    画論 27th The Best Image  2019.12.15 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京  

  89. 舌骨下やリンパ節へのI-131集積は低用量アブレーションの成否に影響するか

    伊藤信嗣、岩野信吾、加藤克彦、長縄慎二

    日本核医学会第59回学術集会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:松山  

  90. 分化型甲状腺癌の術後アブレーションにおける予期せぬトレーサー集積部位の検討

    岩野信吾、伊藤信嗣、伊藤倫太郎、神谷晋一朗、加藤克彦、長縄慎二

    日本核医学会第59回学術集会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:松山  

  91. Glymphatic systemとMRI Invited

    長縄慎二

    第99回慶應医学会総会・シンポジウム 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京  

  92. 定位放射線治療後の組織緩和時間のMRFによる測定:標的領域と周辺領域の評価

    田岡俊昭、大宝和博、川井 恒、中根俊樹、伊藤倫太郎、加藤 裕、市川和茂、奥平訓康、伊藤善之、川口浩和、村田勝俊、丸山克也、 Gregor Koerzdoerfer, Josef Pfeuffer, Mathias Nittka, 長縄慎二

    第47回日本磁気共鳴医学会大会  

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    Event date: 2019.9

    Language:English  

    Venue:熊本  

  93. Glymphatic system and Gadolinium based contrast agents

    Shinji Naganawa

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    Event date: 2019.9

    Language:Japanese  

  94. 腹部大動脈瘤に対するステントグラフト内挿術(EVAR)

    堀口瞭太、竹原康雄、杉山将隆、兵藤良太、駒田智大、松島正哉、川井 恒、長縄慎二、水野 崇、櫻井康雄、阿部真治、小森芳秋

    第1回 4D-Flow研究会 

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    Event date: 2019.9

    Presentation type:Oral presentation (general)  

    Venue:熊本  

  95. 腹部大動脈に対するEndovascular Aneurysmal Repairは内臓動脈の血流を増加させる(4D-Flowによる血行動態解析)

    杉山将隆、竹原康雄、堀口瞭太、兵藤良太、駒田智大、長縄慎二、礒田治夫、牛尾貴輔、五島 聡、若山哲也、野崎 敦、Marcus Alley

    第1回 4D-Flow研究会 

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    Event date: 2019.9

    Presentation type:Oral presentation (general)  

    Venue:熊本  

  96. 健常者とEVAR術前後の腹部大動脈瘤患者のEnergy Loss

    水野 崇、竹原康雄、杉山将隆、堀口瞭太、長縄慎二、櫻井康雄、加藤 裕、阿部真治、礒田治夫、佐藤智宏、石口恒男、田所匡典、野崎 敦

    第1回 4D-Flow研究会 

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    Event date: 2019.9

    Presentation type:Oral presentation (general)  

    Venue:熊本  

  97. 特別講演Ⅱ 脳の老廃物排泄機構とMRI Invited

    長縄慎二

    第11回お茶の水 Neuroimaging Conference-ONIC- 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京  

  98. 7テスラMR装置の高空間分解能3次元位相コントラスト磁気共鳴法を利用した脳血流動態解析の精度検証

    田嶋駿亮、礒田治夫、福永雅喜、小森芳秋、Roshani Perera、水野 崇、定藤規弘、長縄慎二 

    第86回東海総合画像医学研究会 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋  

  99. 中枢神経系原発anaplastic lymphoma kinase陽性未分化大細胞リンパ腫の1例

    佐々木裕太郎、中道玲瑛、川井 恒、田岡俊昭、長縄慎二、川島直実、下山芳江

    第86回東海総合画像医学研究会 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋  

  100. 早期乳癌に対する乳房温存手術+術中放射線部分照射:10年の結果

    川村麻里子、伊藤善之、大宝和博、岡田 徹、伊藤淳二、大家祐実、加茂前健、長縄慎二

    日本医学放射線学会第166回中部地方会 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢  

  101. 術前診断が困難であった膵lymphangiomaの1例

    小川 浩、竹原康雄、長縄慎二、高見秀樹、中黒匡人

    日本医学放射線学会第166回中部地方会 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢  

  102. 肝内門脈静脈短絡に対し塞栓術を施行した2例

    松島正哉、駒田智大、山田恵一郎、堀口瞭太、伊藤 準、兵藤良太、岩野信吾、長縄慎二、石津洋二、田中 卓、馬越弘泰

    第66回中部IVR研究会 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢  

  103. 舌骨下やリンパ節へのI-131集積は分化型甲状腺癌患者に対する低用量アブレーションの成否に影響するか)

    伊藤信嗣、岩野信吾、長縄慎二、加藤克彦

    日本核医学会 第89回中部地方会 

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    Event date: 2019.7

    Language:Japanese  

    Venue:金沢  

  104. MR imaging of endolymphatic hydrops; What is right, what is wrong, and what is new. Invited

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    Event date: 2019.6

    Presentation type:Oral presentation (invited, special)  

  105. 感染契機の肺動脈仮性動脈瘤からの喀血に対し塞栓術を施行した1例

    山田恵一郎、兵藤良太、堀口瞭太、伊藤 準、松島正哉、駒田智大、長縄慎二、進藤有一郎、長坂 憲

    第48回日本IVR学会総会 

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    Event date: 2019.5 - 2019.6

    Presentation type:Poster presentation  

    Venue:福岡  

  106. Comparison single treatment planning and multiple planning for multiple targets in Cyberknife therapy. International conference

    Motoki Kumagai, Kazuhiro Ohtakara, Takeshi Kamomae, Fumitaka Kawabata, Kuniyasu Okudaira, Yoshiyuki Itoh, Shinji Naganawa

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    Event date: 2019.4

    Language:English  

  107. Novel electron density based-CT image from single-and dual-energy scanning for radiation therapy treatment planning. International conference

    Takeshi Kamomae, Fumitaka Kawabata, Takayoshi Nakaya, Kuniyasu Okudaira, Motoki Kumagai, Yoshikazu Miyake, Hiroshi Oguchi, Yoshiyuki Itoh, Shinji Naganawa

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    Event date: 2019.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  108. AI(Artificial intelligence)と画像診断~世界の潮流をふまえて~ International conference

    長縄慎二

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    Event date: 2019.2 - 2019.3

    Language:English  

    Country:Austria  

  109. 前立腺癌小線源治療に対するSpaceOARの使用経験

    伊藤淳二、伊藤善之、大宝和博、岡田 徹、川村麻里子、大家祐実、長縄慎二、藤田高史

    日本医学放射線学会第165回中部地方会 

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    Event date: 2019.2 - 2016.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:豊明   Country:Japan  

  110. MR Fingerprintingによる放射線治療前後の組織緩和時間の変化:T1緩和時間、T2緩和時間同時定量の意義

    田岡俊昭、大宝和博、川井 恒、中根俊樹、加藤 裕、川口宏和、丸山克也、村田勝俊、Nittka Mathias、伊藤善之、長縄慎二

    第48回日本神経放射線学会 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:久留米   Country:Japan  

  111. 7テスラMR装置の高空間分解能3次元位相コントラスト磁気共鳴法を利用した脳血流動態解析の精度検証

    田嶋駿亮、礒田治夫、福永雅喜、小森芳秋、水野 崇、定藤規弘、長縄慎二

    第48回日本神経放射線学会 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:久留米   Country:Japan  

  112. マンモPET検診が発見契機となったMRI検出DCIS症例について

    佐竹弘子、石垣聡子、長縄慎二、田所匡典

    第10回DCIS研究会 

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    Event date: 2019.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎   Country:Japan  

  113. マンモPET検診が発見契機となったMRI検出DCIS症例について

    佐竹弘子、石垣聡子、長縄慎二、田所匡典

    第10回DCIS研究会 

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    Event date: 2019.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:長崎  

  114. Evaluation of haemodynamic and morphological biomarkers to assess the rupture risk of intracranial aneurysms using magnetic resonance fluid dynamics and computational fluid dynamics.

    Roshani Perera, Haruo Isoda, Shunsuke Tajima, Takashi Mizuno, Masaki Terada, Takehiro Naito, Chiharu Tanoi, Takashi Izumi, Yasuo Takehara, Toshihiko Wakabayashi, Harumi Sakahara, Shinji Naganawa

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    Event date: 2019.1

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  115. Glymphatic system hypothesis and MR imaging: Implication for Endolymphatic hydrops, diffusion and gadolinium deposition in brain.

    Shinji Naganawa

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    Event date: 2018.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  116. 4D Flow MRIによる腎動脈上・下腹部大動脈における反射波の影響の差についての検討、逆流方向の血流の比較

    杉山将隆、竹原康雄、大石直樹、若山哲也、野崎 敦、Marcus Alley、牛尾貴補、長縄慎二、阪原晴海

    第3回国際磁気共鳴医学会 日本支部年次学術集会  

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  117. 人工知能と画像診断

    長縄慎二

    名古屋大学脳とこころの研究センター市民公開講座 「目指せ!健康脳:最新の診断、予防、治療」 

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    Event date: 2018.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  118. Glymphatic system:State of the art science International conference

    Shinji Naganawa

    AIMS Neuroimaging in Chicago 2018 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Chicago, USA   Country:United States  

  119. A Matched Study Comparing Right Portal Vein Embolization with and without Segment 4 Portal Vein Embolization for Right Hepatic Trisectionectomy. International conference

    Jun Ito, Tomohiro Komada, Masahiro Nakatochi, Fumie Kinoshita, Yumiko Kobayashi, Kojiro Suzuki, Shinji Naganawa

    104th Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Chicago, USA   Country:United States  

  120. Commissioning and quality assurance of CyberKnife tumor-tracking intensity modulated radiation therapy (IMRT) using dynamic thorax phantom. International conference

    Kohei Kawata, Takeshi Kamomae, Fumitaka Kawabata,Kuniyasu Okudaira,Hiroshi Oguchi

    2018 Nagoya-Yonsei University Research Exchange Meeting on Health Sciences 

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    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Nagoya, Japan   Country:Japan  

  121. Glymphatic system 仮説とMRI

    長縄慎二

    第37回日本認知症学会学術集会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  122. 放射線抵抗性子宮頸癌の半導体レーザによる温熱機器の開発とその実用化

    伊藤善之、香西由加、木村香菜、川村麻里子、中原理絵、大家祐実、髙瀬裕樹、奥村真之、伊藤淳二、岡田 徹、大宝和博、長縄慎二、山田啓一郎、中村誠司

    日本放射線腫瘍学会第31回学術大会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  123. 早期声門癌に対するS-1併用化学放射線治療の成績

    髙瀬裕樹、木村香菜、伊藤善之、大宝和博、岡田 徹、川村麻里子、伊藤淳二、中原理絵、大家祐実、香西由加、藤本保志、長縄慎二

    日本放射線腫瘍学会第31回学術大会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

  124. 腹膜播種を伴う横紋筋肉腫に対しIMRTを用いて全腹腔照射行った1例

    川村麻里子、奥平訓康、伊藤善之、大宝和博、岡田 徹、中原理絵、 伊藤淳二、大家祐実、木村香菜、髙瀬裕樹、長縄慎二

    日本放射線腫瘍学会第31回学術大会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

  125. 遠隔転移を契機に発見された浸潤性小葉癌の2 例

    松本篤子、石垣聡子、佐竹弘子、角田伸行、稲石貴弘、長縄慎二

    第54回日本医学放射線学会秋季臨床大会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  126. 肝右3 区域切除術前の門脈塞栓術~門脈P4 塞栓の有用性を検討したmatched study~

    伊藤 準、駒田智大、長縄慎二、中杤昌弘、木下文恵、小林由美子、鈴木耕次郎

    第54回日本医学放射線学会秋季臨床大会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  127. 低b値(b=500s/m㎡)拡散強調像による脳脊髄駅動態の評価

    田岡俊昭、長縄慎二、川井恒、中根俊樹

    第8回生理学研究所・名古屋大学医学系研究科合同シンポジウム 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:名古屋   Country:Japan  

  128. 腹腔動脈根部の嚢状瘤に対して、balloon assistによるNeck-plastyを行った瘤内塞栓術の1例

    駒田智大、山田恵一郎、堀口瞭太、伊藤 準、兵藤良太、松島正哉、長坂 憲

    第69回 東海IVR懇話会 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  129. Glymphatic system仮説とMRI:最近の動向 Glymphatic system hypothesis and MR imaging: Recent status

    長縄慎二

    第46回日本磁気共鳴医学会大会 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  130. Evaluating the dynamics of cerebrospinal fluid using low b-value diffusion weighted images: Septum pellucidum in dilated ventricle 低b値拡散強調像による脳脊髄液動態評価の試み: 脳室拡張と透明中隔

    田岡俊昭、川井 恒、中根俊樹、長縄慎二

    第46回日本磁気共鳴医学会大会 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  131. フローダイバーター設置後に周囲脳動脈に経時的に血流動態変化を来した大型内頸動脈流の1例

    田嶋駿亮、礒田治夫、泉 孝嗣、塚田哲也、櫻井康雄、長縄慎二

    第84回東海総合画像医学研究会 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  132. 淡明細胞乳頭状腎細胞癌の2例

    山田恵一郎、松島正哉、長縄慎二、後藤百万、都筑豊徳

    第84回東海総合画像医学研究会 

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    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  133. コンピュータ支援診断によるPart-solid肺癌の容積計測:充実成分容積は予後を予測する

    神谷晋一朗、岩野信吾、馬越弘泰、伊藤倫太郎、島本宏矩、中村彰太、長縄慎二

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  134. 分化型甲状腺癌術後患者に対するⅠ-131アブレーション―血中サイログロブリン高値を示す患者へのⅠ-131高用量投与は推奨されるか

    伊藤信嗣、岩野信吾、長縄慎二、加藤克彦

    日本核医学会第87回中部地方会 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  135. 膵頭十二指腸切除後のGDA断端部からの遅発性出血に対してVIABAHNで治療した1例

    駒田智大、山田恵一郎、堀口瞭太、伊藤 準、 兵藤良太、松島正哉、長縄慎二 館 靖 高見秀樹、山田 豪

    第64回中部IVR研究会 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  136. Impact of the glymphatic system on the kinetric and distribution of gadodiamide in the rat brain: Observation by dynamic MRI and effect of circadian rhythm on tissue gadolinium concentrations. International conference

    Toshiaki Taoka,Gregor Jost, Shinji Naganawa, Hubertus Pietsch

    International Society for Magnetic Resonance in Medicine 2018(ISMRM 2018) 

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Paris, France   Country:France  

  137. Blood flow measurement using 3D cine PC MRI within the abdominal aortic aneurysm and visceral arteries in pre- and post-EVAR condition; blood flow in the SMA might be improved after EVAR. International conference

    Masataka Sugiyama, Yasuo Takehara, Tetsuya Wakayama, Atsushi Nozaki, Marcus Alley, Takasuke Ushio, Shinji Naganawa, Harumi Sakahara

    International Society for Magnetic Resonance in Medicine 2018(ISMRM 2018) 

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Paris, France   Country:France  

  138. Usefulness of 4D flow in the Diagnosis of Atrial Septal Defects in Adults. International conference

    Mamoru Takahashi, Yasuo Takehara, Norihiro Tooyama, Katsutoshi Ichijo, Tomoyasu Amano, Yoshikazu Nagura, Kouichi Mizuno, Takuya Matsumoto, Tomoyuki Okuaki, Harumi Sakahara

    International Society for Magnetic Resonance in Medicine 2018(ISMRM 2018) 

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    Event date: 2018.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Paris, France   Country:France  

  139. Leakage of IV-gadolinium to CSF; Where does it from? International conference

    Shinji Naganawa

    German-Japanese Radiological Affilication 19th Workshop 

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    Event date: 2018.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Okayama, Japan   Country:Japan  

  140. 膵管内乳頭粘液性腫瘍との鑑別が困難であった膵蛭(すいてつ) 症の1例

    小川 浩、竹原康雄、長縄慎二、山口淳平、下山芳江

    第32回日本腹部放射線学会 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鎌倉   Country:Japan  

  141. 分枝膵管を主体とするITPN( intraductal tubulopapillary neoplasm)の1例

    堀口瞭太、小川 浩、竹原康雄、長縄慎二、山口淳平、下山芳江

    第32回日本腹部放射線学会 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  142. 診断教授の教室での放射線治療専門医の育成

    長縄慎二

    第77回日本医学放射線学会総会 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  143. 交連線維方向の拡散に注目した拡散によるGlymphatic系の評価

    田岡俊昭、増谷佳孝、川井 恒、中根俊樹、長縄慎二

    第77回日本医学放射線学会総会 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  144. 脳内の老廃物排出システム(Glymphatic system)と脳内ガドリニウム沈着

    田岡俊昭、長縄慎二

    第77回日本医学放射線学会総会 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  145. 論文執筆は楽しい

    長縄慎二

    第77回日本医学放射線学会総会 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  146. UICC8版に基づく臨床病期Ⅰ期肺癌の予後評価

    岩野信吾、馬越弘泰、神谷晋一朗、伊藤倫太郎、島本宏矩、長縄慎二

    第77回日本医学放射線学会総会 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  147. Superficial Learning about "Deep Learning":What Radiologists Should Know

    伊藤倫太郎、岩野信吾、長縄慎二

    第77回日本医学放射線学会総会 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  148. すりガラス影を有する肺癌における充実成分の3D容積計測と予後との相関

    神谷晋一朗、岩野信吾、馬越弘泰、伊藤倫太郎、島本宏矩、中村彰太、長縄慎二

    第77回日本医学放射線学会総会 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  149. 乳腺混合性腫瘤の画像所見:USとMRIを中心に International conference

    石垣聡子、佐竹弘子、林 葉子、松本篤子、角田伸行、長縄慎二

    第77回日本医学放射線学会総会 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  150. SNR Plenary Lecture[Glymphatic System and MR Imaging: Implication for Endolymphatic] International conference

    Shinji Naganawa

    The 12th Asian-Oceanian Congress of NeuroradiologyThe 12th Asian-Oceanian Congress of Neuroradiology 

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    Event date: 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Taipei, Taiwan   Country:Taiwan, Province of China  

  151. Texture analysis of low grade glioma: differential diagnosis between diffuse astrocytoma and oligodendroglioma. International conference

    Hisashi Kawai, Toshiaki Taoka, Toshiki Nakane, Yasuo Sakurai, Shinji Naganawa

    The 12th Asian-Oceanian Congress of Neuroradiology 

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    Event date: 2018.3

    Language:English   Presentation type:Poster presentation  

    Venue:Taipei, Taiwan   Country:Taiwan, Province of China  

  152. Texture analysis of low grade glioma: differential diagnosis between diffuse astrocytoma and oligodendroglioma. International conference

    Shinji Naganawa

    The 12th Asian-Oceanian Congress of Neuroradiology 

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    Event date: 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Taipei, Taiwan   Country:Taiwan, Province of China  

  153. Future of Contrast Mediaの総合司会 International conference

    画像診断セミナー in Wien 

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    Event date: 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Austria  

  154. Gd presence in the brain: impact of daytime and anaesthesia International conference

    Toshiaki Taoka, G. Jost, Shinji Naganawa, H. Pietsch

    European Congress of Radiology 2018 (ECR) 

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    Event date: 2018.2 - 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Vienna, Austria   Country:Austria  

  155. 4D flow analysis of abnormal haemodynamics within saccular aneurysm in contrast to fusiform aneurysm in abdominal aorta. International conference

    Masataka Sugiyama, Yasuo Takehara, Marcus Alley, N. Unno, K. Katahashi, Tetsuya Wakayama, A. Nozaki, , Shinji Naganawa, Harumi Sakahara

    European Congress of Radiology 2018 (ECR) 

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    Event date: 2018.2 - 2018.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Vienna, Austria   Country:Austria  

  156. 子宮頸癌放射線療法後の晩期有害事象とその経時的変化の解析

    山田剛大、石原俊一、河井通泰、伊藤善之、長縄慎二、池田 充

    日本医学放射線学会第163回中部地方会 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長久手   Country:Japan  

  157. TNM分類(UICC 8版)に基づいた臨床病期Ⅰ期肺癌の予後評価

    岩野信吾、馬越弘泰、神谷晋一朗、島本宏矩、伊藤倫太郎、長縄慎二

    日本医学放射線学会第163回中部地方会 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長久手   Country:Japan  

  158. 胆道閉塞症術後の胃静脈瘤に対してBRTOを施行した1歳児の1例

    伊藤 準、館 靖、堀口瞭太、馬越弘泰、長坂 憲、松島正哉、駒田智大、長縄慎二、大島一夫、鈴木耕次郎

    第63回中部IVR・第64回関西IVR合同研究会 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長久手   Country:Japan  

  159. Glymphatic system仮説とMRI;最近の動向(ランチョンセミナー4での講演)

    長縄慎二

    第47回日本神経放射線学会  

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば   Country:Japan  

  160. ラット脳内ガドリニウム沈着における概日リズムおよび麻酔の影響

    田岡俊昭、Gregor Jost、長縄慎二、Hubertus Pietsch

    第47回日本神経放射線学会  

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば   Country:Japan  

  161. 総合司会

    長縄慎二

    第10回名古屋分子標的イメージングセミナー 

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    Event date: 2018.2

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  162. Part-solid肺癌における充実部分の3D体積計測:予後との相関

    神谷晋一朗、岩野信吾、馬越弘泰、伊藤倫太郎、島本宏矩、中村彰太、長縄慎二

    第10回呼吸機能イメージング研究会学術集会 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪   Country:Japan  

  163. 開会挨拶

    長縄慎二

    名古屋大学 脳とこころの研究センターシンポジウム 

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    Event date: 2018.1

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  164. MRIでめまいを見る International conference

    長縄慎二

    名古屋大学脳とこころの研究センター 市民公開講座 総合テーマ「脳とこころの病気の予防と治療に向けて」 

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    Event date: 2018.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  165. Glymphatic SystemとMRI International conference

    長縄慎二

    第63回九州MRI研究会 

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    Event date: 2018.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  166. 巨大脳動脈瘤の上流と下流を対象とした磁気共鳴流体力学解析による堆積流量の測定

    水野 祟、磯田治夫、泉 孝嗣、田嶋駿亮、塚田哲也、櫻井康雄、小森芳秋、長縄慎二

    第83回東海総合画像医学研究会 

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    Event date: 2018.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  167. 分枝膵管を主体とするITPNに腎癌を合併した1例

    堀口遼太、小川 浩、長縄慎二、山口淳平、馬嶋 剛、下山芳江

    第83回東海総合画像医学研究会 

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    Event date: 2018.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  168. Optimized treatment strategy for early glottic squamous cell carcinomas: An initial analysis. International conference

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Seiji Kubota, Mariko Kawamura, Shinji Naganawa

    103rd Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2017.11 - 2017.12

    Language:English   Presentation type:Poster presentation  

    Venue:Chicago, USA   Country:United States  

  169. Computer-Aided Volumetry of the Three-Dimensional Solid Component Size in Part-solid Lung Cancer: Correlation with Prognosis. International conference

    Shinichiro Kamiya, Shingo Iwano, Hiroyasu Umakoshi, Rintaro Ito, Shinji Naganawa

    103rd Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2017.11 - 2017.12

    Language:English   Presentation type:Poster presentation  

    Venue:Chicago, USA   Country:United States  

  170. Kinetic Volume Analysis on Dynamic Contrast-Enhanced MRI of Triple Negative Breast Cancer: Association with Survival Outcomes. International conference

    Yoko Hayashi, Hiroko Satake, Satoko Ishigaki, Mariko Kawamura, Hisashi Kawai, Shinji Naganawa

    103rd Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2017.11 - 2017.12

    Language:English   Presentation type:Poster presentation  

    Venue:Chicago, USA   Country:United States  

  171. Glymphatic systemの可視化に向けて

    長縄慎二

    名古屋大学脳とこころの研究センター 第二回 拡大ワークショップ 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  172. hT2w-3D-FLAIRシーケンスにおけるTR延長による低濃度ガドリニウム造影剤の信号値増加

    加藤 裕、長縄慎二、田岡俊昭、川井 恒、卜蔵公紀、櫻井康雄、

    第54回日本磁気共鳴医学会大会 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:栃木   Country:Japan  

  173. びまん性星細胞腫と乏突起膠腫とのテクスチャ解析での鑑別

    川井 恒、田岡俊昭、中根俊樹、櫻井康雄、長縄慎二

    第54回日本磁気共鳴医学会大会 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:栃木   Country:Japan  

  174. MP2RAGEを用いた視床内部構造の抽出

    中根俊樹、田岡俊昭、川井 恒、加藤 裕、櫻井康雄、丸山克也、長縄慎二

    第54回日本磁気共鳴医学会大会 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:栃木   Country:Japan  

  175. 多施設共同研究:1回2.25GyによるⅠ期声門癌の放射線治療

    伊藤善之、久保田誠司、中原理絵、川村麻里子、長縄慎二、野本由人、村尾豪之、山川耕二、石原俊一、平澤直樹、浅野晶子、柳川繁雄

    日本医学放射線学会第162回中部地方会 

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    Event date: 2017.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  176. すりガラス影を有する肺癌における充実成分の3D半自動計測:予後との相関

    神谷晋一朗、岩野信吾、馬越弘泰、伊藤倫太郎、長縄慎二

    日本医学放射線学会第162回中部地方会 

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    Event date: 2017.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  177. 短期間に新たな瘤が出現、破裂したsegmental arterial mediolysisの1例

    堀口瞭太、松島正哉、伊藤 準、馬越弘泰、長坂 憲、駒田智大、館 靖、長縄慎二、古森公浩、鈴木耕次郎

    第62回中部IVR研究会 

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    Event date: 2017.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  178. Accuracy of Clinical Staging for Small-sized Lung Cancer by Multi-detector Row CT and PET/CT. International conference

    Hiroyasu Umakoshi, Shingo Iwano, Kohei Yokoi, Takayuki Fukui, Koji Kawaguchi, Rintaro Ito, Hironori Shimamoto, Shinji Naganawa

    World Congress Thoracic Imaging Boston 

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    Event date: 2017.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  179. How Does Gd Enter the Brain, When the BBB is Intact? Invited International conference

    Shinji Naganawa

    International Society for Magnetic Resonance in Medicine 2017(ISMRM 2017) 

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    Event date: 2017.4

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Honolulu, Hawai, USA   Country:United States  

  180. Evaluating Glymphatic System by Diffusion Images: Alzheimer's Disease Cases Analyzed by Diffusion Tensor Image Analysis Along Perivascular Space(DTI-ALPS). International conference

    Toshiaki Taoka, Yoshitaka Masutani, Hisashi Kawai, Toshiki Nakane, Kiwamu Matsuoka, Fumihiko Yasuno, Shinji Naganawa

    International Society for Magnetic Resonance in Medicine 2017(ISMRM 2017) 

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    Event date: 2017.4

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Honolulu, Hawai, USA   Country:United States  

  181. Delayed FLAIRでの迷路信号の左右非対称

    長縄慎二、川井 恒、中根俊樹、田岡俊昭、曽根三千彦

    第76回日本医学放射線学会総会 

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    Event date: 2017.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  182. トリプルネガティブ乳癌におけるダイナミックMRIの三次元的容積解析:生存との相関について

    林 葉子、佐竹弘子、石垣聡子、川村麻里子、川井 恒、長縄慎二

    第76回日本医学放射線学会総会 

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    Event date: 2017.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  183. 乳がん術中照射部位の経時的変化

    川村麻里子、伊藤善之、久保田誠司、岡田 徹、大家祐実、木村香菜、香西由加、高瀬裕樹、佐竹弘子、長縄慎二

    第76回日本医学放射線学会総会 

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    Event date: 2017.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  184. CTテクスチャ解析を用いた局所進行直腸癌における術前化学療法の治療効果予測の検討

    石垣聡子、川井 恒、田岡俊昭、二橋尚志、佐竹弘子、上原、長縄慎二

    第76回日本医学放射線学会総会 

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    Event date: 2017.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  185. 造影Dual-energy CTによる原発性肺癌の局所浸潤性予測:腺癌と扁平上皮癌の比較 

    岩野信吾、伊藤倫太郎、島本宏矩、馬越弘泰、長縄慎二

    第76回日本医学放射線学会総会 

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    Event date: 2017.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  186. MDCTとPET/CTによる肺癌ステージングの精度

    岩野信吾、馬越弘泰、伊藤倫太郎、島本宏矩、長縄慎二

    第76回日本医学放射線学会総会 

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    Event date: 2017.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  187. Tract based DTI-ALPS法によるアルツハイマー病症例でのGlymphatic system評価の試み 

    田岡俊昭、増谷佳孝、川井 恒、中根俊樹、長縄慎二

    第76回日本医学放射線学会総会 

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    Event date: 2017.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  188. Closing Remarks International conference

    Shinji Naganawa

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    Event date: 2017.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Vienna, Austria   Country:Austria  

  189. The efficacy of percutaneous transhepatic portal vein embolozation using gelatin sponge particles and metallic coils. International conference

    Tomohiro Komada, Kojiro Suzuki, Masaya Matsushima, Yoshine Mori, Ken Nagasaka, Hiroyasu Umakoshi, Tomoki Ebata, M Nagino, Shinji Naganawa

    European Congress of Radiology 2017(ECR) 

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    Event date: 2017.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  190. A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological. International conference

    intaro Ito, Shingo Iwano, Hironori Shimamoto, Hiroyasu Umakoshi, Shinji Ito, Katsuhiko Kato, Shinji Naganawa

    European Congress of Radiology 2017(ECR) 

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    Event date: 2017.3

    Language:English   Presentation type:Poster presentation  

    Venue:Vienna, Austria   Country:Japan  

  191. Pattern difference in the area with T2-hyperintensity: comparison between gliomas and edemas by using texture analysis. International conference

    Hisashi Kawai, Toshiaki Taoka, Toshiki Nakane, Yasuo Sakurai, Shinji Naganawa

    European Congress of Radiology 2017(ECR) 

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    Event date: 2017.3

    Language:English   Presentation type:Poster presentation  

    Venue:Vienna, Austria   Country:Austria  

  192. 原発性肺癌の術前臨床病期診断の正確性

    岩野信吾、馬越弘泰、伊藤倫太郎、島本宏矩、長縄慎二

    日本医学放射線学会 第161回中部地方会 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重   Country:Japan  

  193. イピリムマブに伴う下垂体炎の3例

    加藤理恵子、川井 恒、田岡俊昭、長縄慎二、岩間信太郎

    日本医学放射線学会 第161回中部地方会 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重   Country:Japan  

  194. 子宮頸部小細胞癌21例の臨床的検討

    川村麻里子、伊藤善之、岡田 徹、久保田誠司、木村香菜、香西由加、高瀬裕樹、長縄慎二、内海 史、吉川史隆

    日本医学放射線学会 第161回中部地方会 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重   Country:Japan  

  195. FDG-PETによる非小細胞肺癌の予後予測因子の検討:SUVmaxと体積を考慮した指標の比較

    伊藤信嗣、岩野信吾、伊藤倫太郎、長縄慎二、加藤克彦

    日本核医学会 第84回中部地方会 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重   Country:Japan  

  196. 肝被膜下血腫による肝コンパートメント症候群に対し血管塞栓術と血腫腫ドレナージを施行した1例

    伊藤 準、松島正哉、馬越弘泰、長坂 憲、駒田智大、鈴木耕次郎、長縄慎二、石津洋二

    第61回中部IVR研究会 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:三重   Country:Japan  

  197. 早期声門癌の個別化された治療方針とその治療成績

    木村香菜、伊藤善之、岡田 徹、久保田誠司、川村麻里子、中原理絵、大家祐実、香西由加、高瀬裕樹、長縄慎二、藤本保志、平松真理子、西尾直樹、都築秀典、

    第34回東海頭頸部腫瘍研究会 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  198. 多施設共同研究―第3報 Ⅰ期声門癌の1回2.25Gyによる放射線治療の実態調査

    伊藤善之、久保田誠司、野本由人、村尾豪之、山川耕二、石原俊一、浅野晶子、平澤直樹、川村麻里子、柳川繁雄、長縄慎二

    第34回東海頭頸部腫瘍研究会 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  199. Glymphatic systemとMRI:内リンパ水腫やガドリニウム脳蓄積との関連

    長縄慎二

    第46回日本神経放射線学会 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  200. Glymphatic system評価に向けて:DTI analysis along Perivascular Space(DTI-ALPS)でのAlzheimer症例の検討

    田岡俊昭、増谷佳孝、川井 恒、中根俊樹、長縄慎二

    第46回日本神経放射線学会 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  201. Glymphatic system評価に向けて:Gd造影剤静注4時間後の各液体腔信号の造影剤種間の比較

    長縄慎二、川井 恒、田岡俊昭

    第46回日本神経放射線学会 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  202. 社内招聘勉強会での講師

    長縄慎二

    富士製薬工業(株) 社内招聘勉強会 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  203. 胸壁並行断面CTによる間質性肺炎の経時的評価

    馬越弘泰、岩野信吾、伊藤倫太郎、島本宏矩、長縄慎二

    第9回呼吸機能イメージング研究会学術集会 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

  204. 内耳疾患についての臨床講演会 講師

    長縄慎二

    内耳疾患についての臨床講演会 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  205. 腎静脈に発生した平滑筋肉腫の2例

    林 葉子、松島正哉、長縄慎二、松尾かずな、後藤百万

    第81回東海総合画像医学研究会 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  206. 経時差分3D-CTコンピュータ支援診断による肺癌の脊椎転移の検出

    岩野信吾、伊藤倫太郎、長縄慎二

    第57回日本肺癌学会学術集会 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  207. 肺癌の局所浸潤性の予測における多相造影Dual-energy CTとFDG-PET/CT所見の比較

    伊藤倫太郎、岩野信吾、長縄慎二

    第57回日本肺癌学会学術集会 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  208. Delayed FLAIR:内リンパ水腫とその先にあるもの

    長縄慎二

    第43回東海めまい平衡障害研究会 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  209. CLINICAL ADVANTAGES OF A ROBOTIC RADIOSURGERY SYSTEM EQUIPPED WITH A MULTI-LEAF COLLIMATOR IN PROSTATE STEREOTACTIC BODY RADIATION THERAPY. International conference

    Masashi Tomida, Junji Suzuki, Hironori Takahashi, Kyohei Hamajima, Takeshi Kamomae, Yoichi Ohashi, Hiroshi Oguchi, Takahito Okuda

    International Conference on Medical Physios 2016 

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    Event date: 2016.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Bangkok, Thailand   Country:Thailand  

  210. Development of patient-specific three-dimensional-printed phantoms for artificial in vivo dosimetry. International conference

    Takeshi Kamomae, Hidetoshi Shimizu, Takayoshi Nakaya, Kuniyasu Okudaira, Yoshikazu Miyake, Masataka Komori, Hiroshi Oguchi, Tomohiro Komada, Yoshiyuki Itoh, Shinji Naganawa

    International Conference on Medical Physios 2016 

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    Event date: 2016.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Bangkok, Thailand   Country:Thailand  

  211. Detection of Primary and Metastatic Lesions of Urinary Tract Tumors by 18F-FLT PET/CT. International conference

    Katsuhiko Kato, Yumiko Koshiba, Shinji Abe, Masayuki Honda,Keita Knimoto, Tetsuro Odagawa, Atsushi Murai, Shinji Naganawa

    102st Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2016.11 - 2016.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Chicago, USA   Country:Japan  

  212. Intracellular volume fraction image on NODDI in diffuse axonal injury. International conference

    Toshiaki Taoka, Hisashi Kawai, Toshiki Nakane, Kazuo Okuchi, Kimihiko Kichikawa, Shinji Naganawa, Toshiteru Miyasaka

    102st Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2016.11 - 2016.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  213. Quantitative Follow-Up of Interstitial Pneumonia Using 3D-Curved High-Resolution CT Imaging Parallel to the Chest Wall. International conference

    Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    102st Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2016.11 - 2016.12

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Chicago, USA   Country:United States  

  214. 頭部領域、MRIのおさえておきたい3つのポイント International conference

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    Event date: 2016.11 - 2016.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Chincago, USA   Country:United States  

  215. 乳癌術中照射用プレートの改良

    川村麻里子、加茂前健、伊藤善之、岡田 徹、久保田誠司、木村香菜、香西由香、大家祐実、高瀬裕樹、長縄慎二

    日本放射線腫瘍学会第29回学術大会 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  216. 個別化・細分化された早期声門癌に対する放射線治療成績

    木村香菜、伊藤善之、岡田 徹、久保田誠司、川村麻里子、中原理絵、大家祐実、香西由加、高瀬裕樹、長縄慎二、藤本保志

    日本放射線腫瘍学会第29回学術大会 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  217. 救急外来診療や国家試験に役立つ症例クイズ:MRを中心に

    長縄慎二

    第56回日本核医学会学術総会  

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  218. 甲状腺びまん性硬化型乳頭癌の1例

    林 葉子、石垣聡子、佐竹弘子、菊森豊根、長縄慎二

    日本超音波医学会第37回中部地方会 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  219. PHITSを用いた放射線治療用電子線に対する金属粉含有機能紙の遮蔽性能評価

    加茂前健、門前 一、川村麻里子、奥平訓康、中谷隆佳、向山隆史、末澤正太郎、川端文隆、杉田和真、三宅良和、小口 宏、伊藤善之、長縄慎二

    PHITS研究会 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:静岡   Country:Japan  

  220. Delayed FLAIRでの迷路信号の左右非対称:片側偶発前庭神経鞘腫例と片側内リンパ水腫例の比較

    長縄慎二、中根俊樹、川井 恒、田岡俊昭、曾根三千彦、

    第44回日本磁気共鳴医学会大会 

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    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  221. T2強調像での高信号域におけるテクスチャ解析による検討: gliomaと浮腫との比較

    川井 恒、田岡俊昭、中根俊樹、長縄慎二 

    第44回日本磁気共鳴医学会大会 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大宮、埼玉   Country:Japan  

  222. Neurite orientation dispersion and density imaging (NODDI)による結節性硬化症症例の白質の変化の検討

    第44回日本磁気共鳴医学会大会 

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大宮、埼玉   Country:Japan  

  223. Development of a patient-specific QA system by three-dimensional printing technique

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    Event date: 2016.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  224. Current state of MRI imaging for Meniere's disease International conference

    Korean Vongress of Radiology (KCR) 2016 

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    Event date: 2016.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Seoul, Korea   Country:Korea, Republic of  

  225. 特別講演 講師

    長縄慎二

    第295回関西NR勉強会 学術講演会 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  226. 膵尾部に生じた気管支原性嚢胞の1例

    鈴木耕次郎、小川 浩、長縄慎二、山田 豪、佐藤 啓

    第30回日本腹部放射線学会 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:金沢   Country:Japan  

  227. 子宮頸癌の放射線治療成績

    石原俊一、高田 章、中道玲瑛、石口裕章、河井通泰、梅村康太、河合要介、伊藤善之、川村麻里子、長縄慎二

    日本医学放射線学会第160回中部地方会 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  228. 非小細胞肺癌の局所浸潤性の予測に関する造影dual energy CT とFDG-PET/CT の比較

    伊藤倫太郎、岩野信吾、島本宏矩、馬越弘泰、伊藤信嗣、長縄慎二、加藤克彦

    日本医学放射線学会第160回中部地方会 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  229. 胸壁並行断面CT による間質性肺炎の経時的評価

    馬越弘泰、岩野信吾、伊藤倫太郎、島本宏矩、長縄慎二

    日本医学放射線学会第160回中部地方会 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  230. 早期声門癌に対するS-1 併用化学放射線療法の長期成績

    高瀬裕樹、伊藤善之、木村香菜、岡田 徹、久保田誠司、川村麻里子、中原理絵、大家祐実、香西由加、長縄慎二、藤本保志、曾根三千彦

    日本医学放射線学会第160回中部地方会 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  231. 分化型甲状腺癌術後患者に対するⅠ-131 1110MBq アブレーション:血中サイログロブリン高値を示す患者への適応の検討

    伊藤信嗣、岩野信吾、長縄慎二、加藤克彦

    日本核医学会 第83回中部地方会 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  232. 胆膵領域の術後肝外門脈出血に対するステントグラフト治療

    鈴木耕次郎、馬越弘泰、長坂 憲、松島正哉、駒田智大、長縄慎二、水野隆史、江畑智希、梛野正人

    第60回中部IVR研究会 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  233. Contrast enhancement of perivascular spaces in the basal ganglia. International conference

    Shinji Naganawa

    German-Japanese Radiological Affilication 18th Workshop 

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    Event date: 2016.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Germany  

  234. Contrast enhancement of perivascular spaces in the basal ganglia. International conference

    Shinji Naganawa, Toshiaki Taoka

    International Society for Magnetic Resonance in Medicine 2016(ISMRM 2016) 

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    Event date: 2016.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Singapore  

  235. 造影dual-energy CTによる小型肺癌の局所浸潤評価

    島本宏矩、岩野信吾、馬越弘泰、伊藤倫太郎、長縄慎二

    第75回日本医学放射線学会総会 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  236. Contrast Enhancement of Perivascular Space in Basal Ganglia. 大脳基底核血管周囲腔の造影効果

    第75回日本医学放射線学会総会 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  237. Time course of the changes in white matter microstructure of small infarctions using neurite orientation dispersion and density imaging(NODDS.)

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    Event date: 2016.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  238. 胸部CTの経時サブトラクションCADによる肺癌の脊椎骨転移の検出

    第75回日本医学放射線学会総会 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  239. 胸壁並行断面CTを用いた間質性肺炎の定量的評価

    馬越弘泰、岩野信吾、伊藤倫太郎、島本宏矩、長縄慎二

    第75回日本医学放射線学会総会 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  240. 多施設共同研究-第2報 I期声門癌の1回2.25Gyによる放射線治療の実態調査

    伊藤善之、久保田誠司、野本由人、村尾豪之、山川耕二、石原俊一、浅野晶子、平澤直樹、長縄慎二

    第33回東海頭頸部腫瘍研究会 

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    Event date: 2016.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  241. 眼球内シリコンオイルの頭蓋内迷入の2例

    川井 恒、田岡俊昭、中根俊樹、櫻井康雄、佐竹弘子、長縄慎二

    第45回日本神経放射線学会  

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    Event date: 2016.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山形   Country:Japan  

  242. 「Glioblastomaらしさ」とは何か?:テクスチャ解析による定量の試み

    田岡俊昭、川井 恒、中根俊樹、長縄慎二

    第45回日本神経放射線学会  

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    Event date: 2016.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山形   Country:Japan  

  243. サイバーナイフM6を用いた前立腺癌に対する超寡分割放射線治療の経験

    髙瀨裕樹、奥田隆仁、吉岡 靖、大宝和博、伊藤 誠、鈴木淳司、高橋宏典、丹羽まい子、久保田恵章、伊藤善之、長縄慎二

    日本医学放射線学会第165回中部地方会 

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    Event date: 2016.2 - 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:豊明   Country:Japan  

  244. 脳神経画像診断―最近の話題―

    長縄慎二

    名古屋城北放射線クリニック 設立5周年記念 学術講演会 

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    Event date: 2016.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  245. 表在性悪性病変に対する温熱機器の開発とその臨床応用

    副松由加、伊藤善之、久保田誠司、川村麻里子、中原理絵、伊藤淳二、岡田 徹、長縄慎二、木村香菜、加茂前 健、山田啓一郎、中村誠司

    日本医学放射線学会第159回中部地方会 

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    Event date: 2016.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  246. サイバーナイフM6の初期使用経験

    奥田隆仁、太田尚寿、川上賢二、鈴木淳司、高橋宏典、冨田真司、浜島恭平、伊藤善之、加茂前 健、長縄慎二、横田尚樹

    日本医学放射線学会第159回中部地方会 

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    Event date: 2016.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  247. 分化型甲状腺癌の転移巣における18F-FDG PET/CTと18F-FLT PET/CTの画像所見の比較

    村井淳志、加藤克彦、伊藤信嗣、岩野信吾、長縄慎二

    日本核医学会第82回中部地方会 

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    Event date: 2016.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  248. The Structure of Medullary Veins in the Cerebral Hemisphere and Relating Disorders. International conference

    Toshiaki Taoka, Akio Fukusumi, Toshiteru Miyasaka, Takeshi Wada, Kimihiko Kichikawa, Shinji Naganawa, Tomoko Ochi, Hisashi Kawai

    101st Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2015.11 - 2015.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  249. Superiority of heavily T2-weighted 3D-FLAIR over regular 3D-FLAIR for the detection of cochlear lymph fluid signal abnormality in patients with sudden sensorineural hearing loss. International conference

    Shinji Naganawa, Toshiaki Taoka, Shingo Iwano, Hisashi Kawai, Michihiko Sone, Mitsuru Ikeda

    101st Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2015.11 - 2015.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  250. 造影Dual-Energy CTによる肺癌の診断:Iodine Volumeと病理学的分化度との相関

    岩野信吾、長縄慎二

    第56回日本肺癌学会学術集会 

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    Event date: 2015.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  251. A randomized, double-blind pilot trial of hydrolyzed rice bran versus placebo for radioprotective effect on abute gastroenteritis secondary to chemoradiotherapy in patients with cervical cancer.

    Yoshiyuki Itoh, Mitsuru Ikeda, Mika Mizuno, Fumitaka Kikkawa, Rie Nakahara, Seiji Kubota, Junji Ito, Tohru Okada, Mariko Kawamura, Yuka Soematsu, Shinji Naganawa

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    Event date: 2015.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  252. Treatment outcomes of radiation therapy with high-dose-rate intracavitary br achytherapy for recurrent cervical cancer after radical or simple hysterectomy.

    Yuka Soematsu, Yoshiyuki Itoh, Rie Nakahara, Seiji Kubota, Junji Ito, Mariko Kawamura, Tohru Okada, Shinji Naganawa

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    Event date: 2015.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  253. Clinical and pathological outcome of the neoadjuvant radiochemotherapy (NAC-RT) to locally advanced non-small cell lung cancer.

    Mariko Kawamura, Yoshiyuki Itoh, Seiji Kubota, Tohru Okada, Junji Ito, Rie Nakahara, Yuka Soematsu, Takeshi Kamomae, Shinji Naganawa

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    Event date: 2015.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  254. Multicenter survey for T1 glottic cancer treated with 2.25 Gy per fraction in clinical practice.

    Seiji Kubota, Yoshiyuki Itoh, Rie Nakahara, Yoshihito Nomoto, Syunichi Ishihara, Takayuki Murao, Kouji Yamakawa, Naoki Hirasawa, Akiko Asano, Junji Ito, Mariko Kawamura, Tohru Okada, Shinji Naganawa

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    Event date: 2015.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  255. Characterization of Stochastic Noise and Post-Exposure Density Growth for Reflective-Type Radiochromic Film in Therapeutic Photon Beam Dosimetry. International conference

    Takeshi Kamomae, Masataka Oita, Naoki Hayashi, Motoharu Sasaki, Hideki Aoyama, Yoshiyuki Itoh, Shinji Naganawa

    15th Asia-Oceania Congress of Medical Physics 

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    Event date: 2015.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:China  

  256. High Dose Rate Intracavitary Brachytherapy for Recurrent Cancer of Vaginal Stump After Hysterectomy. International conference

    Yuka Soematsu, Yoshiyuki Itoh, Rie Nakahara, Seiji Kubota, Junji Ito, Mariko Kawamura, Tohru Okada, Shinji Naganawa

    American Society for Radiation Oncology 57th Annual Meeting (ASTRO) 

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    Event date: 2015.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  257. US, MMG, MRI Changes After Intraoperative Radiation Therapy of Breast Cancer. International conference

    Mariko Kawamura, Yoshiyuki Itoh, Seiji Kubota, Tohru Okada, Junzi Itoh, Hiroko Satake, Shinji Naganawa, Yuka Soematsu

    American Society for Radiation Oncology 57th Annual Meeting (ASTRO) 

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    Event date: 2015.10

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  258. Brain response to overhearing one's name: An fMRI study. International conference

    Toshiki Nakane, Makoto Miyakoshi, Toshiharu Nakai, Shinji Naganawa

    Neuroscience 2015 

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  259. Predictive factors for the outcome of I-131 1110MBq ablation therapy in the patients with differentiated thyroid cancer: urinary iodine, serum thyroglobulin, and uptake to thyroid bed. International conference

    Shinji Ito, Shingo Iwano, Katsuhiko Kato, Shinji Naganawa

    28th Annual Congress of the European Association of Nuclear Medicine 

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    Event date: 2015.10

    Language:English   Presentation type:Poster presentation  

    Country:Germany  

  260. Comparison between FDG-PET and DWIBS in diagnosing neuroblastoma of child. International conference

    Hiroaki Ishiguchi, Shinji Ito, Yusuke Sakurai, Hisashi Kawai, Katsuhiko Kato, Shinji Naganawa, Asahito Hama, Hideki Muramatsu, Yoshiyuki Takahashi, Seiji Kojima

    28th Annual Congress of the European Association of Nuclear Medicine 

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    Event date: 2015.10

    Language:English   Presentation type:Poster presentation  

    Country:Germany  

  261. Predictive factors for the outcome of I-131 1110MBq ablation therapy in the patients with differentiated thyroid cancer: urinary iodine, serum thyroglobulin, and uptake to thyroid bed. International conference

    Shinji Ito, Shingo Iwano, Katsuhiko Kato, Shinji Naganawa

    28th Annual Congress of the European Association of Nuclear Medicine 

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    Event date: 2015.10

    Language:English   Presentation type:Poster presentation  

    Country:Germany  

  262. 膵癌の化学放射線治療後に肝に腫瘤性病変が出現した1例

    高瀬裕樹、小川 浩、久保田誠司、長縄慎二、藤井 努、佐藤 啓

    第51回日本医学放射線学会秋季臨床大会 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:盛岡   Country:Japan  

  263. 胸壁並行断面CTによる肺癌患者の背景肺の評価

    馬越弘泰、岩野信吾、長縄慎二

    第107回日本肺癌学会中部支部学術集会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  264. Dual Energy CTによる小型肺癌の造影評価

    島本宏矩、岩野信吾、馬越弘泰、伊藤倫太郎、長縄慎二

    第107回日本肺癌学会中部支部学術集会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  265. RESOLVEにおけるADC map上のCSF拍動アーティファクトについての検討

    大橋俊夫、篠畑隆一、片桐稔雄、長縄慎二

    第43回日本磁気共鳴医学会大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  266. Ultra-short TE sequence(UTE)における騒音測定、受信coilのスイッチノイズの検討

    櫻井康雄、長縄慎二、川井 恒、田岡俊昭、河村美奈子 、榊原勝浩、松岡祐樹、卜蔵公紀、安藤康生、中井浩大、David Grodzki、丸山克也、市川和茂、米田和夫、小西伊佐実

    第43回日本磁気共鳴医学会大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  267. Multiecho MP-RAGE(MEMPR) 法による造影3D-T1強調像でのTEの違いによる影響の検討

    川井 恒、長縄慎二、中根俊樹、櫻井康雄、田岡俊昭、丸山克也

    第43回日本磁気共鳴医学会大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  268. 突発性難聴での蝸牛リンパ液信号上昇の検出:3D-FLAIRに対するheavy T2強調3D-FLAIRの優位性

    長縄慎二、川井 恒、曾根三千彦、池田 充

    第43回日本磁気共鳴医学会大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  269. Pointwise Encoding Time reduction with Radial Acquisition(PETRA)におけるMagic Angle Effectの検討

    市川和茂、長縄慎二、川井 恒、櫻井康雄、河村美奈子、榊原勝浩、松岡祐樹、卜蔵 公紀、安藤康生、小西伊佐実、熊澤 智宇、David Grodzki、丸山克也、米田和夫

    第43回日本磁気共鳴医学会大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  270. 神経膠腫のNeurite orientation dispersion and density imaging(NODDI)画像の検討

    田岡俊昭、川井 恒、中根俊樹、宮坂俊輝、越智朋子、堀 沙恵香、吉川 公彦、長縄 慎二

    第43回日本磁気共鳴医学会大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  271. DSC法とDCE法による神経膠腫の血管漏出の評価:ヒストグラム解析による検討

    田岡俊昭、川井 恒、中根俊樹、宮坂俊輝、越智朋子、堀 沙恵香、吉川 公彦、長縄 慎二

    第43回日本磁気共鳴医学会大会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  272. 膵癌の化学放射線治療後に肝に腫瘍性病変が出現した1例

    高瀬裕樹、小川 浩、久保田誠司、長縄慎二、藤井 努、佐藤 哲

    第78回東海総合画像医学研究会 

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    Event date: 2015.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  273. 消化管動脈性出血に対する選択的動脈塞栓術の治療効果の検討

    鈴木耕次郎、馬越弘泰、長坂 憲、石口裕章、駒田智大、森 芳峰、長縄慎二

    第21回日本血管内治療学会総会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  274. 表在性悪性病変に対する局所温熱治療の機器開発  その3:臨床評価機器としての3号機の概要

    伊藤善之、副松由加、木村香菜、長縄慎二、山田啓一郎、中村誠司

    第29回東海ハイパーサーミア研究会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  275. 放射線抵抗性子宮頸癌に対するレーザーサーミアによる温熱療法の研究 その4:臨床評価機器による臨床試験の概要

    伊藤善之、副松由加、久保田誠司、川村麻里子、中原理絵、伊藤淳二、岡田 徹、長縄慎二、鈴木史朗、吉川史隆

    第29回東海ハイパーサーミア研究会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  276. Evaluation of Tungsten-Based Functional Paper for Attenuation Device in Intraoperative Radiotherapy for Breast Cancer International conference

    Takeshi Kamomae, Hajime Monzen, Kuniyasu Okudaira, Yoshikazu Miyake, Hiroshi Oguchi, Masataka Komori, Mariko Kawamura, Yoshiyuki Itoh, Toyone Kikumori, Shinji Naganawa

    2015 American Association of Physicists in Medicine(AAPM) 57th Annual Meeting&Exhibition 

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    Event date: 2015.7

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  277. 画像診断(側頭骨・内耳)

    長縄慎二

    第27回日本頭蓋底外科学会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  278. Dual Energy CTによる小型肺癌の造影評価

    島本宏矩、岩野信吾、馬越弘泰、伊藤倫太郎、長縄慎二

    日本医学放射線学会 第158回中部地方会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  279. 高線量率腔内照射を主体とした子宮頸癌術後の膣断端再発・残存に対する放射線治療の成績

    副松由加、伊藤善之、中原理絵、久保田誠司、川村麻里子、 伊藤淳二、岡田徹、長縄慎二、鈴木史朗、吉川史隆

    日本医学放射線学会 第158回中部地方会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  280. 胸壁並行断面CTを用いた間質性肺炎の定量的評価

    馬越弘泰、岩野信吾、伊藤倫太郎、長縄慎二

    日本医学放射線学会 第158回中部地方会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  281. Solid type小型肺癌のFDG-PET/CT所見:腺癌と扁平上皮癌の比較

    伊藤倫太郎、岩野信吾、伊藤信嗣、長縄慎二、加藤克彦

    日本核医学会 第81回中部地方会 

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    Event date: 2015.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  282. Size of vestibular endolymph in patients with isolated lateral semicircular canal dysplasia International conference

    Shinji Naganawa, Hisashi Kawai, Michihiko Sone, Mitsuru Ikeda

    International Society for Magnetic Resonance in Medicine 2015(ISMRM 2015) 

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    Event date: 2015.5 - 2015.6

    Language:English   Presentation type:Poster presentation  

    Country:Canada  

  283. Radiology made easy Ⅳ, Head and neck, Difficult to listen: Radiology of the Petrous Bone International conference

    Shinji Naganawa

    96. Deutscher Röntgenkongress  

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    Event date: 2015.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Germany  

  284. Visualization of middle ear ossicles by ultra-short echo time imaging in elder subjects

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai

    The 74rd Annual Meeting of the Japan Radiological Society  

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    Event date: 2015.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  285. Pancreatic neuroendocrine tumors: Assessment of dynamic contrast-enhanced CT features and the pathological grading

    Ryota Hyodo, Kojiro Suzuki, Hiroshi Ogawa, Tomohiro Komada, Shinji Naganawa

    The 74rd Annual Meeting of the Japan Radiological Society  

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    Event date: 2015.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  286. Multicenter survey for T1 glottic cancer treated with 2.25-Gy fractions in clinical practice

    Seiji Kubota, Yoshiyuki Itoh, Yuka Soematsu, Yoshihito Nomoto, Takayuki Murao, Kouji Yamakawa, Shunichi Ishihara, Shinji Naganawa

    The 74rd Annual Meeting of the Japan Radiological Society  

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    Event date: 2015.4

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  287. Functional imaging of lung cancer using contrast enhanced dual-energy CT: Dose iodine attenuation correlate with histopathology?

    Shingo Iwano, Rintaro Ito, Hiroyasu Umakoshi, Shinji Naganawa

    The 74rd Annual Meeting of the Japan Radiological Society  

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    Event date: 2015.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  288. Pathology Update6 「脳・神経」  司会

    長縄慎二

    第74回日本医学放射線学会総会 

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    Event date: 2015.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  289. Assessment of renal cell carcinoma by two PET tracer : dual-time-point C-11 methionine and F-18 fluorodeoxyglucose International conference

    Shinji Ito, Katsuhiko Kato, Takahito Okuda, S.Maeda, Shinji Naganawa

    European Congress of Radiology 2015(ECR) 

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    Event date: 2015.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  290. Assessment of paraaortic lymph node metastasis in patients with perihilar cholangiocarcinoma; a comparison between contrast-enhanced computed tomography and F-18 fluorodeoxyglucose-positron emission tomography/computed tomography International conference

    Naohiro Furuhashi, Shinji Ito, Katsuhiko Kato, Kojiro Suzuki, Shinji Naganawa

    European Congress of Radiology 2015(ECR) 

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    Event date: 2015.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  291. 多施設協同研究―Ⅰ期声門癌の1回2.25Gyによる放射線治療の実態調査

    伊藤善之、久保田誠司、野本由人、村尾豪之、山川耕二、石原俊一、長縄慎二

    第32回東海頭頸部腫瘍研究会 

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    Event date: 2015.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  292. 早期乳癌に対する乳房温存手術+術中放射線部分照射:第I/II相試験の結果

    川村麻里子、伊藤善之、岡田 徹、久保田誠司、伊藤淳二、副松由加、加茂前健、長縄慎二、菊森豊根、角田伸行

    日本医学放射線学会第157回中部地方会 

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    Event date: 2015.1 - 2015.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  293. 3Dプリンタによる血管モデル作成の試み

    駒田智大、馬越弘泰、長坂 憲、石口裕章、兵藤良太、川井 恒、森 芳峰、鈴木耕次郎、長縄慎二

    第57回中部IVR研究会 

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    Event date: 2015.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  294. 神経芽腫におけるFDG-PETとMRI全身拡散強調像(DWIBS)の画像所見の比較

    石口裕章、伊藤信嗣、櫻井悠介、川井 恒、長縄慎二、加藤克彦

    日本核医学会第80回中部地方会 

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    Event date: 2015.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  295. 診断に苦慮した組織球症の1例

    山田剛大、川井 恒、櫻井悠介、長縄慎二、濱家千絵、佐藤 啓、下山芳江

    第77回東海総合画像医学研究会 

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    Event date: 2015.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  296. 子宮頸癌に対する局所温熱治療の機器開発 第2報:試作2号機の概要

    伊藤善之、木村香菜、副松由加、久保田誠司、伊藤淳二、中原理絵、川村麻里子、岡田 徹、長縄慎二

    日本放射線腫瘍学会第27回学術大会 

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    Event date: 2014.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  297. 子宮頸癌に対する局所温熱試作器を用いた初期組織加温実験

    副松由加、伊藤善之、木村香菜、岡田 徹、久保田誠司、中原理絵、川村麻里子、伊藤淳二、長縄慎二、山田啓一郎、中村誠司

    日本放射線腫瘍学会第27回学術大会 

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    Event date: 2014.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  298. 早期乳癌に対する乳房温存手術・術中放射線部分照射:第I/II相試験 の結果

    川村麻里子、伊藤善之、岡田 徹、久保田誠司、伊藤淳二、中原理絵、副松由加、菊森豊根、角田伸行、長縄慎二

    日本放射線腫瘍学会第27回学術大会 

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    Event date: 2014.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  299. Ⅰ期声門癌に対する1回2.25Gyを用いた寡分割照射例の多施設調査

    久保田誠司、伊藤善之、副松由加、野本由人、村尾豪之、山川耕二、石原俊一、長縄慎二

    日本放射線腫瘍学会第27回学術大会 

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    Event date: 2014.12

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  300. Kinetic Parametric Imaging of Breast Cancer using ynamic Contrast-Enhanced MRI with Routine Clinical Protocols International conference

    Hiroko Satake, Satoko Ishigaki, Mariko Ktano, Hisashi Kawai, Shinji Naganawa

    100th Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2014.11 - 2014.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  301. Investigation of Accuracy of Hemodynamics and Wall Shear Stress for Intracranial Arteries Obtained from MR Fluid Dynamics (MRFD) using 3D Cine Phase-contrast MR Imaging International conference

    Haruo Isoda, Kazushige Ichikawa, Atsushi Fukuyama, Yoshiaki Komori, Takashi Kosugi, Yasuo Takehara, Yuki Onishi , Shinji Naganawa

    100th Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2014.11 - 2014.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  302. Magnetic Resonance Imaging of Vasa Previa: Spectrum of Imaging Findings International conference

    Yusuke Sakurai, Hisashi Kawai, Yoshine Mori, Seiji Sumigama, Shinji Naganawa

    100th Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2014.11 - 2014.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  303. MR Imaging of Cardiac Sarcoidosis: Spectrum of Imaging Findings and Differential Diagnosis International conference

    Tomohiro Komada, Kojiro Suzuki, Hisashi Kawai, Shinji Naganawa

    100th Annual Meeting of Radiological Society of North America(RSNA) 

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    Event date: 2014.11 - 2014.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  304. Evaluation of dosimetric attenuation with new tungsten-based functional paper for intraoperative radiotherapy(IORT) for breast cancer International conference

    Takeshi Kamomae, Yoshiyuki Itoh, Hajime Monxen, Kuniyasu Okudaira, Takayoshi Nakaya, Yoshikazu Miyake, Hiroshi Oguchi, Mariko Kawamura, Tohru Okada, Shinji Naganawa

    14th Asia-Oceania Congress of Medical Physics(AOCMP) & 12th South East Asia Congress of Medical Physics(SEACOMP) 

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    Event date: 2014.10

    Language:English   Presentation type:Poster presentation  

    Country:Viet Nam  

  305. イメージインタープリテーション①(コメンテータ)

    長縄慎二

    第27回頭頸部放射線研究会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  306. ランチョンセミナー13 最先端CT/MRIによる臨床応用

    長縄慎二

    第50回日本医学放射線学会秋季臨床大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  307. シーケンス1 座長

    長縄慎二

    第42回日本磁気共鳴医学会大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  308. MP2RAGEを用いた乳頭視床路の抽出

    中根俊樹、川井 恒、桜井康雄、小出雄太郎、丸山克也、長縄慎二 

    第42回日本磁気共鳴医学会大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  309. 脳血管を対象とした磁気共鳴流体力学の精度検証

    磯田治夫、市川和茂、福山篤司、小森芳秋、小杉隆司、大西有希、竹原康雄、長縄慎二

    第42回日本磁気共鳴医学会大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  310. 静音化Readout segmented EPI (rs-EPI;RESOLVE)の騒音およびapparent diffusion coefficient(ADC)測定

    岩田康平、桜井康雄、長縄慎二、川井 恒、石橋一都、河村美奈子、榊原勝浩、松岡祐樹、ト蔵公紀、安藤康生、小西伊佐実、米田和夫、丸山克也、Grodzki David M.

    第42回日本磁気共鳴医学会大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  311. 通常量Gd静注による内リンパ腔体積測定:撮影時間18分と8分の2種のプロトコルの比較

    大橋俊夫、加納麻衣、篠畑隆一、片桐稔雄、久野佳也夫、長縄慎二

    第42回日本磁気共鳴医学会大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  312. 外側半規管形成異常例における前庭内リンパ腔の大きさの検討

    長縄慎二、川井 恒、曾根三千彦、池田 充

    第42回日本磁気共鳴医学会大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  313. ダイナミック造影MRIにおけるトリプルネガティブ乳癌の定量的検討

    佐竹弘子、石垣聡子、川井 恒、北野真利子、長縄慎二

    第42回日本磁気共鳴医学会大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  314. ultra-short TE sequence(PETRA)による脳動脈の評価:TOF-MR angiographyとの比較

    川井 恒、長縄慎二、桜井康雄、丸山克也、Grodzki David M.

    第42回日本磁気共鳴医学会大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  315. Ultra-short TE sequenceにおけるSusceptibility artifactの検討

    桜井康雄、長縄慎二、川井 恒、石橋一都、河村美奈子、榊原勝浩、松岡祐樹、ト蔵公紀、安藤康生、小西伊佐実、岩田康平、米田和夫、丸山克也、Grodzki David M.

    第42回日本磁気共鳴医学会大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  316. 内耳MRI:臨床応用可能な内リンパ水腫画像~取得方法と評価方法を中心に~

    長縄慎二

    第42回日本磁気共鳴医学会大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  317. 脳血管を対象とした磁気共鳴流体力学の精度検証

    渡辺智哉、磯田治夫、市川和茂、福山篤司、子森芳秋、小杉隆司、大西有希、竹原康雄、長縄慎二

    第76回東海総合画像医学研究会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  318. 硬膜外脂肪肉腫の一例

    馬越弘泰、櫻井悠介、二橋尚志、長縄慎二

    第76回東海総合画像医学研究会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  319. ダイナミックMRIによる乳癌の造影剤薬物動態

    佐竹弘子、石垣聡子、川井 恒、長縄慎二 

    第22回日本乳癌学会学術総会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  320. 肺結節性病変に対する気管支鏡検査前の画像診断の意義(第2報)

    岩野信吾、岸本真理子、北野真利子、伊藤倫太郎、長縄慎二、平川亮弘

    日本医学放射線学会第156回中部地方会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  321. 追跡調査精度と予後~市中病院の場合~

    石原俊一、高田 章、太田尚寿、澤田裕介、伊藤善之、長縄慎二

    日本医学放射線学会第156回中部地方会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  322. 子宮頸癌に対する局所温熱治療の機器開発第2報:試作2号機の概要

    伊藤善之、西山香奈、副松由香、久保田誠司、伊藤淳二、中原理絵、川村麻里子、岡田 徹、長縄慎二、山田啓一郎、中村誠司

    日本医学放射線学会第156回中部地方会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  323. PET/CTによる肝門部胆管癌の傍大動脈領域リンパ節転移評価:造影CTとの比較   

    古橋尚博、伊藤信嗣、鈴木耕次郎、長縄慎二、加藤克彦

    日本核医学会第79回中部地方会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  324. 膵癌大動脈周囲リンパ節転移による下大静脈症候群に対しステント留置が奏功した一例

    長坂 憲、鈴木耕次郎、馬越弘泰、石口裕章、兵藤良太、駒田智大、森 芳峰、長縄慎二

    第56回中部IVR研究会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  325. 主膵管内に巨大な腫瘤を形成したITPNの1例

    駒田智大、鈴木耕次郎、河村綾希子、櫻井悠介、小川 浩、藤井 努、 下山芳江、長縄慎二

    第28回日本腹部放射線学会 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:秋田   Country:Japan  

  326. 膵頭十二指腸切除後の門脈出血に対し,門脈ステントグラフト留置が有用であった1例

    鈴木耕次郎、森 芳峰、駒田智大、石口裕章、兵藤良太、伊神 剛、横山幸浩、江畑智希、梛野正人、長縄慎二

    第32回日本Metallic Stents&Grafts研究会 

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    Event date: 2014.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:奈良   Country:Japan  

  327. Imaging of endolymphatic hydrops in 10minutes: A new strategy for dramatic scan-time reduction International conference

    Naganawa Shinji, Kawai Hisashi, Sone Michihiko, Nakashima Tsutomu,

    German-Japanese Radiological Affilication 17th Workshop 

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    Event date: 2014.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  328. Imaging of endolymphatic hydrops in 10 minutes: A new strategy for dramatic scantime reduction. International conference

    Shinji Naganawa, Tsutomu Nakashima

    International Society of Magnetic Resonance in Medicine(ISMRM) 2014 

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    Event date: 2014.5

    Language:English   Presentation type:Poster presentation  

    Country:Italy  

  329. MR imaging of endolymphatic hydrops in 10 minutes: A new strategy for dramatic scan time reduction

    Shinji Naganawa, Hisashi Kawai, Tsutomu Nakashima

    The 73rd Annual Meeting of the Japan Radiological Society  

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    Event date: 2014.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  330. MR imaging of cardiac sarcoidosis: Evaluation of delayed enhanced segment and layer of the heart

    Tomohiro Komada, Hiroaki Ishiguchi, Shinji Ito, Hisashi Kawai, Yosine Mori, Kojiro Suzuki, Shinji Naganawa

    The 73rd Annual Meeting of the Japan Radiological Society 

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    Event date: 2014.4

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  331. Magnetic resonance imaging of vasa previa

    Yusuke Sakurai, Hisashi Kawai, Yosine Mori, Shinji Naganawa

    The 73rd Annual Meeting of the Japan Radiological Society 

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    Event date: 2014.4

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  332. MR imaging of endolymphatic hydrops in 10 minutes: A new strategy for dramatic scan time reduction. International conference

    Shinji Naganawa, Kiminori Bokura, Hisashi Kawai, Tsutomu Nakashima

    European Congress of Radiology 2014 

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    Event date: 2014.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  333. Trial of Q-Space Imaging using the Readout Segmented Echo Planar Imaging. International conference

    Daisuke Iwase, Atsushi Fukuyama, Haruo Isoda, Katsuya Maruyama, Yoshiaki Komori, Yasuo Sakurai, Shinji Naganawa

    European Congress of Radiology 2014 

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    Event date: 2014.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  334. Prognostic evaluation of small-siza peripheral lung cancers by fluorine-18-fluorodeoxyglucose position emission tomography and thin-section computed tomography. International conference

    Mariko Kishimoto, Shingo Iwano, Katsuhiko Kato, Shinji Ito, Kenichi Kawakami, Mariko Kitano, Naganawa Shinji

    European Congress of Radiology 2014 

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    Event date: 2014.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  335. Comparison of multidetector-row computed tomography findings of IgG4-related sclerosing cholangitis and cholangiocarcinoma. International conference

    Masaki Yata, Kojiro Suzuki, Naohiro Furuhashi, Kenichi Kawakami, Yuichi Kawai, Shinji Naganawa

    European Congress of Radiology 2014 

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    Event date: 2014.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  336. Percutaneous transhepatic portal vein embolization with stenting for perihilar cholangiocurcinoma with severe portal vein stenosis; comparison with usual portal vein embolization. International conference

    Ryota Hyodo, Kojiro Suzuki, Tomoki Ebata, Tomohiro Komada, Yoshine Mori, Hazime Sugawara, Masato Nagino, Shinji Naganawa

    European Congress of Radiology 2014 

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    Event date: 2014.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  337. Correlation between FDG-PET/CT findings and prognosis of pulmoanry squamous cell carcinoma. International conference

    Rintaro Ito, Shingo Iwano, Shinji Ito, Mariko Kishimoto, Shinji Naganawa, Katsuhiko Kato

    European Congress of Radiology 2014 

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    Event date: 2014.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  338. Myocardial motion analysis with the aid of tagged MR images analyzed by optical flow method: a human volunteer comparative study with echocardiography. International conference

    Daiki Tabata, Haruo Isoda, Atsushi Fukuyama, Takashi Kosugi, Katsuya Maruyama, Shinji Naganawa

    European Congress of Radiology 2014 

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    Event date: 2014.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  339. Excretory MR pancreatography after intravenous administration of gadoteridol:preliminary results in eight healthy volunteers. International conference

    Kojiro Suzuki, Shinji Naganawa, Naohiro Furuhashi, Ryota Hyodo, Masahiro Yamazaki

    European Congress of Radiology 2014 

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    Event date: 2014.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  340. 早期声門癌に対するS-1内服療法による同時化学放射線療法

    伊藤善之、西山香菜、藤本保志、中原理絵、牧 紗代、伊藤淳二、久保田誠司、岡田 徹、浅野晶子、平松真理子、丸尾貴志、西尾直樹、鈴木淳志、小出悠介、下野真理子、中島 務、長縄慎二

    第31回東海頭頸部腫瘍研究会 

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    Event date: 2014.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  341. 肺結節性病変に対する気管支鏡検査前の画像診断の意義

    岩野信吾、岸本真理子、北野真利子、伊藤倫太郎、長縄慎二

    日本医学放射線学会第155回中部地方会 

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    Event date: 2014.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  342. 前立腺癌I-125密封小線源治療(±外部照射)の臨床的検討

    牧 紗代、伊藤善之、伊藤淳二、久保田誠司、岡田 徹、浅野晶子、中原理絵、西山香菜、長縄慎二、吉野 能、藤田高史、後藤百万、池田 充

    日本医学放射線学会第155回中部地方会 

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    Event date: 2014.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  343. 食道がんに対する放射線治療成績の検討 

    伊藤淳二、伊藤善之、浅野晶子、岡田 徹、久保田誠司、牧 紗代、中原理絵、西山香菜、長縄慎二

    日本医学放射線学会第155回中部地方会 

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    Event date: 2014.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  344. 選択的動脈塞栓術が奏功した外傷性持続勃起症の1例 

    兵藤良太、鈴木耕次郎、石口裕章、駒田智大、森 芳根、長縄慎二

    日本IVR学会第36回中部・第35回関西合同地方会 

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    Event date: 2014.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  345. 頭蓋内非腫瘍性病変のC-11 メチオニン PET

    伊藤信嗣、二橋尚志、岩野信吾、長縄慎二、藤井正純、若林俊彦、加藤克彦

    日本核医学会第78回中部地方会 

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    Event date: 2014.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  346. 腫瘍性病変との鑑別が困難であった小児骨髄炎の1例

    伊藤倫太郎、中根俊樹、長縄慎二、濱 麻人、筑紫 聡、下山芳江

    第75回東海総合画像医学研究会 

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    Event date: 2014.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  347. 限局性前立腺がんに対するⅠ-125密封小線源治療(±外部照射)300例の臨床的検討

    牧 紗代、伊藤善之、伊藤淳二、久保田誠司、岡田 徹、浅野晶子、中原理絵、長縄慎二、吉野 能、藤田高史、後藤百万 

    第29回前立腺シンポジウム 

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    Event date: 2013.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  348. Dosimetric impact of dental filling materials in volumetric modulated arc therapy for head-and-neck cancer. International conference

    Kamomae Takeshi, Itoh Yoshiyuki, Okudaira K, Tomida M, Nakaya T, Miyake Y, Oguchi H, Komori M, Okada T, Naganawa Shinji

    Kamomae Takeshi, Itoh Yoshiyuki, Okudaira K, Tomida M, Nakaya T, Miyake Y, Oguchi H, Komori M, Okada T, Naganawa Shinji 

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    Event date: 2013.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:Singapore  

  349. Differentiation of focal-type autoimmune pancreatitis from pancreatic carcinoma:assessment by multiphase contrast-enhanced CT International conference

    Furuhashi Naohiro, Suzuki Kojiro, Sakurai Yusuke,Ikeda Mitsuru, Kawai Yuichi, Naganawa Shinji

    Radiological Society of North America(RSNA) 2013 

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    Event date: 2013.11 - 2013.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  350. 分化型甲状腺癌転移巣における18F- FLT PET/CTと 18F-FDG PET/CTの比較

    岩野信吾、加藤克彦、阿部真治、小田川哲郞、岩野信吾、伊藤信嗣、山本誠一、長縄慎二  

    第53回日本核医学会学術総会 

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    Event date: 2013.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  351. Comparison of 18F-FLT PET/CT and 18F-FDG PET/CT in detection of metastases of differentiated thyroid cancer. International conference

    Katsuhiko Kato, Shinji Abe, Tetsuro Odagawa, Yusuke Fujita, Arisa Niwa, Shingo Iwano, Shinji Ito, Mitsuru Ikeda, Shinji Naganawa

    EANM'13(Annual congress of the European Association of Nuclear Medicine) 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:France  

  352. Evaluation of dual-time-point F-18 FDG-PET scans for diagnosis of cancer of the corpus uteri. International conference

    Ito Shinji, Kato Katsuhiko, Okuda Takahito, Iwano Shingo, Naganawa Shinji

    EANM'13(Annual congress of the European Association of Nuclear Medicine) 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:France  

  353. Evaluation of I-123 MIBG uptake into the adrenal medulla in I-123 MIBG scintigraphy. International conference

    Shinji Abe, Katsuhiko Kato, Tetsuro Odagawa, Naotoshi Fujita, Yusuke Fujita, Arisa Niwa, Shinji Naganawa

    EANM'13(Annual congress of the European Association of Nuclear Medicine) 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:France  

  354. Uptake of 18F-FDOPA in the heart muscle of normal humans in 18F-FDOPA PET. International conference

    Katsuhiko Kato, Shinji Abe, Tetsuro Odagawa, Yusuke Fujita, Arisa Niwa, Shinji Naganawa

    EANM'13(Annual congress of the European Association of Nuclear Medicine) 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:France  

  355. Evaluation of dual-time-point F-18 FDG-PET scans for diagnosis of cancer of the corpus uteri International conference

    Ito Shinji, Kato Katsuhiko, Okuda Takahito, Iwano Shingo, Naganawa Shinji

    26th Annual Congress of the European Association of Nuclear Medicine 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:France  

  356. IMRTおよびVMATにおける金属冠が線量分布に及ぼす影響

    加茂前健、伊藤善之、奥平訓康、冨田真司、小口宏、三宅良和、長縄慎二

    日本放射線腫瘍学会第26回学術大会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:青森   Country:Japan  

  357. 当院における脳幹グリオーマの放射線治療成績

    久保田誠司、伊藤善之、伊藤淳二、中原理絵、牧 紗代、岡田 徹、浅野晶子、長縄慎二、加藤克彦、若林俊彦

    日本放射線腫瘍学会第26回学術大会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:青森   Country:Japan  

  358. 子宮頸癌の放射線治療後の局所残存・局所再発病変に対する温熱治療の機器開発

    伊藤善之、西山香菜、久保田誠司、伊藤淳二、中原理絵、牧 紗代、岡田 徹、浅野晶子、長縄慎二

    日本放射線腫瘍学会第26回学術大会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:青森   Country:Japan  

  359. 早期声門癌に対するS-1併用化学放射線療法

    西山香菜、伊藤善之、浅野晶子、岡田 徹、久保田誠司、牧 紗代、中原理絵、伊藤淳二、長縄慎二

    日本放射線腫瘍学会第26回学術大会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:青森   Country:Japan  

  360. IgG4関連硬化性胆管炎と胆管癌の多相造影CTにおける比較

    矢田匡城、鈴木耕次郎、古橋尚博、川上賢一、河合雄一、長縄慎二

    第49回日本医学放射線学会秋季臨床大会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  361. 多相造影CTを用いた限局型自己免疫性膵炎と膵管癌との鑑別

    古橋尚博、鈴木耕次郎、櫻井悠介、池田充、河合雄一、長縄慎二  

    第49回日本医学放射線学会秋季臨床大会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  362. Visualization of white matter tracts using a non-DWI method: Does intravenous gadolinium injection foour hours prior to the examination affect the degree of visualization of white matter tracts? International conference

    30th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2013 Congress) 

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    Event date: 2013.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:France  

  363. FDG-PET/CT は小型肺扁平上皮癌の予後予測因子となるか?

    伊藤倫太郎、岩野信吾、伊藤信嗣、長縄慎二、加藤克彦

    第154回日本医学放射線学会中部地方会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  364. 末梢小型肺癌における術後予後予測

    岸本真理子、岩野信吾、長縄慎二

    第103回日本肺癌学会中部支部会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  365. 通常量Gd静注での内リンパ面積の半定量:2種の処理画像の比較

    長縄慎二、鈴木耕次郎、中道 玲、ト蔵公紀、吉田忠雄、曾根三千彦、中島 務、池田 充、Homann Georg

    第41回日本磁気共鳴学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  366. BLADE-DWIにおけるapparent diffusion coefficient(ADC)計測

    櫻井康雄、長縄慎二、川井 恒、石橋一都、河村美奈子、榊原勝浩、中野 智、松岡祐樹、安藤康生、ト蔵公紀、小西伊佐実、丸山克也、Stemmer Alto、米田和夫

    第41回日本磁気共鳴学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  367. ホルモン受容体陽性乳癌におけるダイナミック造影MRIの定量

    佐竹弘子、石垣聡子、川井 恒、北野真利子、長縄慎二

    第41回日本磁気共鳴学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  368. 低悪性度の神経膠腫におけるDiffusion Kurtsis Imaging(DKI)と11C-Methionine(MET)-PETとの比較

    川井 恒、長縄慎二、二橋尚志、櫻井康雄、丸山克也

    第41回日本磁気共鳴学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  369. Heavily T2-weighted 3D-FLAIRを用いた白質線維描出:静注Gd遅延造影は白質線維描出に影響を与えるか?

    山崎雅弘、長縄慎二、川井 恒、池田 充、ト蔵公紀、礒田治夫、中島 務

    第41回日本磁気共鳴学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  370. オプティカルフローを用いたtagged MR画像による心筋運動解析:心エコーとの比較

    田端大輝、礒田治夫、福山篤司、加藤香緒里、松原宏紀、小杉隆司、丸山克也、長縄慎二

    田端大輝、礒田治夫、福山篤司、加藤香緒里、松原宏紀、小杉隆司、丸山克也、長縄慎二 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  371. Readut Segmented EPIを用いたQ-Space Imaging解析の試み

    岩瀬大祐、福山篤司、礒田治夫、丸山克也、小森芳秋、長縄慎二、櫻井康雄

    第41回日本磁気共鳴学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  372. 頸部領域における3次元シネ位相コントラスト磁気共鳴を用いた血流動態解析の精度検証

    登澤一輝、礒田治夫、福山篤司、丸山克也、小森芳秋、小杉隆司、竹原康雄、長縄慎二

    第41回日本磁気共鳴学会 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  373. コントラストMRIの功績-私の経験した症例 presence,absence,think different

    長縄慎二

    第41回日本磁気共鳴医学会大会 イブニングシンポジウム 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  374. コントラストMRIの功績-私の経験した症例 presence,absence,think different

    長縄慎二

    第41回日本磁気共鳴医学会大会 イブニングシンポジウム 

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    Event date: 2013.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  375. 鞍上部病変のPET診断

    村井淳志、二橋尚志、伊藤信嗣、川井恒、加藤克彦、長縄慎二、藤井正純、若林俊彦

    第74回 東海総合画像医学研究会 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  376. 新しい温熱機器による子宮頚癌放射線治療後の局所依存・局所再発病変に対する温熱療法の開発

    伊藤善之、西山香菜、長縄慎二、山田啓一郎、中村誠司

    第27回 東海ハイパーサーミア研究会 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  377. 腹腔動脈狭窄を伴う膵動脈瘤のTAE -中長期成績-

    鈴木耕次郎、石口裕章、兵藤良太、古橋尚博、川上賢一、駒田智大、森芳峰、 丸山邦宏、長縄慎二

    第19回日本血管内治療学会 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:青森   Country:Japan  

  378. 子宮頚癌の(化学)放射線療法後の局所残存・局所再発病変に対する温熱療法-開発の経緯と機器の概要

    伊藤善之、久保田誠司、西山香菜、飛田理世、伊藤淳二、中原理絵、牧 紗代、岡田 徹、浅野晶子、長縄慎二

    第154回日本医学放射線学会中部地方会 

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    Event date: 2013.6 - 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  379. 当院におけるdiffuse intrinsic pontine glioma (DIPG)の放射線治療成績

    久保田誠司、伊藤善之、伊藤淳二、中原理絵、牧 紗代、岡田 徹、浅野晶子、長縄慎二

    第154回日本医学放射線学会中部地方会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  380. 急性腎後性腎不全で発症した局所進行子宮頸癌 -化学放射線療法により治癒し得た1例-

    飛田理世、久保田誠司、伊藤淳二、中原理絵、牧 紗代、岡田 徹、浅野晶子、伊藤善之、長縄慎二

    第154回日本医学放射線学会中部地方会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  381. 当院における頭頚部扁平上皮癌に対する術後照射の検討

    中原理絵、伊藤善之、西山香菜、飛田理世、伊藤淳二、牧 紗代、久保田誠司、岡田 徹、浅野晶子、長縄慎二

    第154回日本医学放射線学会中部地方会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  382. 卵巣動脈瘤破裂による後腹膜出血に対し塞栓術を施行した1例

    石口裕章、森 芳峰、兵藤良太、駒田智大、鈴木耕次郎、長縄慎二、伊藤茂樹

    第35回日本IVR学会中部地方会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  383. 分化型甲状腺癌に対する I-131 アブレーション:当施設における投与量 30mCi と 100mCiの比較検討

    伊藤信嗣、岩野信吾、長縄慎二、加藤克彦

    第77回日本核医学会中部地方会 

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    Event date: 2013.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  384. 門脈狭窄を伴う進行肝門部胆管癌術前の門脈ステント併用下 PTPE の検討

    兵藤良太、鈴木耕次郎、江畑智希、石口裕章、高田章、森芳峰、菅原元、梛野正人、長縄慎二

    第42回IVR学会総会 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  385. 放射性ヨードが集積した炎症性肺疾患の2例

    矢田匡城、伊藤慎二、岩野信吾、加藤克彦、長縄慎二

    第50回腫瘍・免疫核医学研究会 

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    Event date: 2013.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  386. MR imaging of Meniere's disease by intratympanic (IT) and intravenous (IV) injection of Gd-DTPA: Double contrast injection and a novel imaging strategy, HYDROPS2 for IT+IV International conference

    Shinji Naganawa, Masahiro Yamazaki, Hisashi Kawai, Kiminori Bokura, Michihiko Sone, Tsutomu Nakashima

    ISMRM2013 

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    Event date: 2013.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  387. Fast T1-mapping用 3D-GREシークエンスによる鼓室内Gd投与後の造影効果推定

    長縄慎二、山崎 雅弘、川井 恒、中島 務

    第71回日本医学放射線学会総会 

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    Event date: 2013.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  388. メニエール病のMRIによる簡便な客観診断法;How to do it

    長縄慎二、山崎雅弘、川井 恒、中島 務

    第72回日本医学放射線学会総会 

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    Event date: 2013.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  389. 同室CTによるIGRTを用いた前立腺癌IMRT-直腸の晩期有害事象の検討

    牧 紗代、伊藤善之、久保田誠司、岡田 徹、伊藤淳二、中原理絵、浅野晶子、長縄慎二、吉野 能、池田 充

    第72回日本医学放射線学会総会 

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    Event date: 2013.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  390. 腎細胞癌のPET-F-18 FDGとC-11メチオニンの比較

    伊藤信嗣、加藤克彦、松尾啓司、岩野信吾、長縄慎二

    第72回日本医学放射線学会総会 

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    Event date: 2013.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  391. 乳腺領域のダイナミック造影MRI:Tissue 4Dによる定量評価と病理学的予後予測因子との対比

    石垣聡子、佐竹弘子、川井 恒、北野真利子、長縄慎二

    第72回日本医学放射線学会総会 

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    Event date: 2013.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  392. コンピュータ支援診断(CAD)を用いた3次元CTによる肺葉容積計測

    岩野信吾、北野真利子、松尾啓司、川上賢一、古池 亘、岸本真理子、長縄慎二

    第72回日本医学放射線学会総会 

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    Event date: 2013.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  393. PETで偽陰性所見を呈した充実型肺癌の検討

    岩野信吾、伊藤信嗣、土屋賢一、加藤克彦、長縄慎二

    第72回日本医学放射線学会総会 

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    Event date: 2013.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  394. Clinically applicable objective diagnosis of Meniere's disease by MR:How ""to do"" it International conference

    S.Naganawa, M.Yamazaki, H.Kawai, T.Nakashima

    European Congress of Radiology 2013 

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    Event date: 2013.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  395. Validation of accuracy for 3D cine phase-Contrast MR imaging(4D-Flow) with the aid of an aotric phantom International conference

    M.Mori, H.Isoda, A. Fokuyama, T.Haba, K.Maruyama, T.Shimizu, Y.Takehara, S.Naganawa

    European Congress of Radiology 2013 

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    Event date: 2013.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  396. Myocardial motion analysis with the aid of tagged MR images analyzed by optical flow method International conference

    D.Tabata, H.Isoda, A.Fukuyama, T.Shimizu, T.Kosugi, K.Maruyama, S.Naganawa

    European Congress of Radiology 2013 

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    Event date: 2013.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  397. The effect of section thickness on MDCT lung densitometry International conference

    M.Kitano, S.Iwano, K.Matsuo, K.Kawakami, W.Koike, M.Kishimoto, S.Naganawa

    European Congress of Radiology 2013 

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    Event date: 2013.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  398. What causes false-negative PET findings for solid-type lung cancer? International conference

    S.Iwano, S.Ito, K.Tsuchiya, K.Kato, S.Naganawa

    European Congress of Radiology 2013 

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    Event date: 2013.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  399. Visualization of cantral nerve tracts using a non-EPI, non-DWI method International conference

    M.Yamazaki, S.Naganawa, K.Bokura, H.Kawai

    European Congress of Radiology 2013 

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    Event date: 2013.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  400. PET陰性を呈した充実型肺癌の検討

    岩野信吾、伊藤信嗣、土屋賢一、長縄慎二、加藤克彦

    第102回日本肺癌学会中部支部会 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  401. 神経線維腫症I型患者に生じた脊髄内過誤腫様病変の1例

    中根俊樹、川井 恒、長縄慎二、今釜史郎、伊藤全哉、下山芳江

    第42回日本神経放射線学会 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:小倉   Country:Japan  

  402. 乳腺MRIにおける背景乳腺の造影効果の予測

    河村綾希子、佐竹弘子、石垣聡子、木村麗子、川井 恒、長縄慎二、池田 充、島本佳寿広

    第21回日本乳癌画像研究会 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  403. FDG-PET/CTとthin-section CTによる末梢小型肺癌の予後予測

    岩野信吾、岸本真理子、伊藤信嗣、長縄慎二、加藤克彦

    日本医学放射線学会第153回中部地方会 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:豊明市   Country:Japan  

  404. ネダプラチンと5-FUの同時併用による子宮頚癌化学放射線療法の長期成績

    中原理絵、伊藤善之、品川貴郁、西山香菜、飛田理世、伊藤淳二、牧 紗代、久保田誠司、岡田 徹、浅野晶子、長縄慎二

    日本医学放射線学会第153回中部地方会 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:豊明市   Country:Japan  

  405. 全身性エリテマトーデスに合併した子宮頚癌に対して化学放射線療法を施行した1例

    品川貴郁、伊藤善之、浅野晶子、岡田 徹、久保田誠司、牧 紗代、伊藤淳二、中原理絵、長縄慎二、今井健史、梅津朋和、吉川史隆、尾崎武徳、石原俊一

    日本医学放射線学会第153回中部地方会 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:豊明市   Country:Japan  

  406. 当院における原発不明頸部リンパ節転移症例の治療成績

    西山香菜、中原理絵 、伊藤善之 、浅野晶子、岡田 徹 、久保田誠司、牧 紗代、伊藤淳二、長縄慎二、藤本保志

    日本医学放射線学会第153回中部地方会 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:豊明   Country:Japan  

  407. 腸腰動脈-腰動脈からのtype Ⅱ endoleakに対して塞栓術を施行した3例

    石口裕章、高田 章、兵藤良太、古橋尚博、川上賢一、森 芳峰、鈴木耕次郎、長縄慎二

    日本IVR学会第34回中部地方会 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:豊明市   Country:Japan  

  408. 放射性ヨードが集積を示した炎症性肺疾患の2例

    矢田匡城、伊藤信嗣、土屋賢一、岩野信吾、長縄慎二、加藤克彦

    日本核医学会第76回中部地方会 

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    Event date: 2013.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:豊明市   Country:Japan  

  409. 右上腕に発生した巨大solitary fibrous tumorの1例

    兵藤良太、高田 章、長縄慎二、浦川 浩、下山芳江

    第24回骨軟部放射線研究会 

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    Event date: 2013.1 - 2013.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  410. 男性乳癌の6例

    飛田理世、石垣聡子、北野真利子、長縄慎二

    第73回東海総合画像医学研究会 

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    Event date: 2013.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  411. Prone-to-Supine Tumor Displacement of the Breast. International conference

    SATAKE HIROKO, ISHIGAKI SATOKO, KAWAI HISASHI , NAGANAWA SHINJI

    RSNA2012(Radiological Society of North America ) 

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    Event date: 2012.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  412. Uptake of F-18 FDOPA in the Corpus Striatum of Normal Brain in F-18 FDOPA PET. International conference

    KATO KATSUHIKO , ODAGAWA TETSURO , ABE SHINJI , IKED MITSURU, SHIMAMOTO AKAZUHIRO , NAGANAWA SHINJI

    RSNA2012(Radiological Society of North America ) 

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    Event date: 2012.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  413. Background Parenchymal Enhancement in Preoperative Breast MRI. International conference

    NUNAMI SATOKO,ISHIGAKI SATOKO,SATAKE HIROKO,KAWAMURA AKIKO,KAWAI HISASHI,NAGANAWA SHINJI

    RSNA2012(Radiological Society of North America ) 

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    Event date: 2012.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  414. Detection of Urinary Tract Cancer by C-11 Choline PET/CT or F-18 FDG PET/CT. International conference

    KATO KATSUHIKO, ITO SHINJI, ABE SHINJI, ODAGAWA TETSURO , IKEDA MITSURU, SHIMAMOTO KAZUHIRO , NAGANAWA SHINJI

    RSNA2012(Radiological Society of North America ) 

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    Event date: 2012.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  415. F-18 FDG-PET/CT for Evaluation of I-131 Radioiodine Therapy for Bone Metastases of Differentiated Thyroid Carcinoma. International conference

    ITO SHINJI, IWANO SHINGO, KATO KATSUHIKO, NAGANAWA SHINJI

    RSNA2012(Radiological Society of North America ) 

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    Event date: 2012.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  416. Segmentectomy Planning Using 3D-CTA with a Virtual Safety Margin for Early Stage Lung Cancer. International conference

    IWANO SHINGO, USAMI NORIYASU, YOKOI KOHEI , NAGANAWA SHINJI

    RSNA2012(Radiological Society of North America ) 

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    Event date: 2012.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  417. Objective Diagnosis of Meniere's Disease by Clinically Applicable MRI Method: How "to Do" It International conference

    NAGANAWA SHINJI, YAMAZAKI MASAHIRO, KAWAI HISASHI , NAKASHIMA TSUTOMU

    RSNA2012(Radiological Society of North America ) 

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    Event date: 2012.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  418. 子宮頸癌術前同時化学放射線療法の病理組織学的効果と予後の関連

    久保田誠司、伊藤善之、伊藤淳二、中原理絵、牧紗代、岡田徹、石原俊一、長縄慎二

    日本放射線腫瘍学会第25回学術大会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  419. 仮想3Dマージン法による肺癌区域切除術の術前計画

    岩野信吾、長縄慎二、宇佐美範恭、横井香平

    第53回日本肺癌学会総会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山   Country:Japan  

  420. 仮想気管支鏡ナビゲーションCADの精度

    岸本真理子、岩野信吾、長縄慎二、井上努

    第53回日本肺癌学会総会 

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    Event date: 2012.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山   Country:Japan  

  421. Differentiation of newly diagnosed Glioblastoma multiforme and intracranial diffuse large B cell lymphoma using C-11 -methionine and F-18-FDG PET. International conference

    OKADA YUMIKO, NIHASHI TAKASHI,FUJII MASAZUMI, KATO KATSUHIKO,OKOUCHI YOSHIYUKI,ANDO YOSHIO,YAMASHITA MASATO,MAESAWA SATOSHI,TAKEBAYASHI SHIGENORI,WAKABAYASHI TOSHIHIKO,NAGANAWA SHINJI

    European Association of Nuclear Medicine(EANM)2012 

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    Event date: 2012.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  422. F-18 fluorodeoxyglucose positron emission tomography for uterine and adnexal carcinosarcoma. International conference

    HAYASAKA KAZUMASA, TAKIZAWA KEN, NIHASHI TAKASHI, KOYAMA MASAMICHI, SAITOH TOMOYA, MIWA KENTA

    European Association of Nuclear Medicine(EANM)2012 

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    Event date: 2012.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  423. Clinical use of 11C-methionine and 18F-FDG PET for germinoma in central nervous system. International conference

    OKOCHI YOSHIYUKI, NIHASHI TAKASHI,FUJII MASAZUMI,KATO KATSUHIKO,OKADA YUMIKO,ANDO YOSHIO, MAESAWA SATOSHI,TAKEBAYASHI SHIGENORI,WAKABAYASHI,NAGANAWA SHINJI

    European Association of Nuclear Medicine(EANM)2012 

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    Event date: 2012.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  424. Comparison of Met-PET and FDG-PET for renal cell carcinoma. International conference

    ITO SHINJI,KATO KATSUHIKO,MATSUO KEIJI,IWANO SHINGO,NAGANAWA SHINJI

    European Association of Nuclear Medicine(EANM)2012 

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    Event date: 2012.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  425. Assessment of the accuracy of 3D-PET/CT for the quantitative brain study. International conference

    TADOKORO MASANORI,SHIRAKAWA SEIJI,KATO KATSUHIKO,KATO TAKASHI,ITO KENGO

    European Association of Nuclear Medicine(EANM)2012 

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    Event date: 2012.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  426. 甲状腺癌に対するI-131内用療法におけるSPECT/CTの有用性

    岩野信吾、伊藤信嗣、土屋賢一、長縄慎二、加藤克彦

    第52回日本核医学会学術総会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  427. シリコンフォトマルを用いた動物用超高分解能PET装置の開発

    山本誠一、渡部浩司、金井泰和、加藤克彦、畑澤順

    第52回日本核医学会学術総会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  428. 11C-cholinePET/CT 及び 18F-FDG PET/CTの尿路癌検出能に関する検討

    加藤克彦、阿部真治、岩野信吾、伊藤信嗣、小田川哲郞、池田充、山本誠一、長縄慎二

    第52回日本核医学会学術総会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  429. 同時多発肺癌に対し仮想3D マージン法による術前手術シミュレーションを行った2例

    岩野信吾、長縄慎二、横井香平、宇佐美範恭、北野真利子、川上賢一、岸本真理子

    第48回日本医学放射線学会 秋季臨床大会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎   Country:Japan  

  430. 脳血管ファントムを用いた3次元シネ位相コントラスト磁気共鳴法の血流動態と壁せん断応力の精度検証

    礒田治夫、市川和茂、福山篤司、羽場友信、丸山克也、小杉隆司、清水利恭、竹原康雄、長縄慎二

    第40回日本磁気共鳴医学会大会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  431. 当院におけるDiffusion Kurtosis Imagingの初期経験

    川井恒、長縄慎二、櫻井康雄、丸山克也

    平成24年度名古屋大学脳とこころの研究センターシンポジウム 創薬に向けた脳機能研究の新展開 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  432. 等倍量静注Gdによるメニエール病の内リンパ水腫描出;外リンパ陽性画像からT2強調画像の差分の有用性

    長縄慎二、山崎雅弘、川井 恒、卜蔵公紀、櫻井康雄、曾根三千彦、中島 務

    第40回日本磁気共鳴医学会大会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  433. 大動脈ファントムを用いた3次元シネ位相コントラスト磁気共鳴法(4D-Flow)の精度検証

    礒田治夫、森 麻里香、福山篤司、羽場友信、丸山克也、清水利恭、小杉隆司、竹原康雄、長縄慎二

    第40回日本磁気共鳴医学会大会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  434. Readout segmented EPI (rs-EPI; RESOLVE)におけるapparent diffusion coefficient (ADC)計測の特徴

    櫻井康雄、長縄慎二、川井 恒、石橋一都、河村美奈子、榊原勝浩、中野 智、松岡祐樹、安藤康生、卜蔵公紀、丸山裕輝、丸山克也、David Porter、米田 和夫

    第40回日本磁気共鳴医学会大会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  435. Heavily T2強調3D-FLAIRによる中枢神経路描出

    山崎雅弘、長縄慎二、卜蔵公紀、川井 恒

    第40回日本磁気共鳴医学会大会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  436. Diffusion kurtosis imagingによる腫瘍周囲の浮腫の検討 -浸潤性星細胞腫と転移性腫瘍との比較-

    川井 恒、長縄慎二、櫻井康雄、丸山克也

    第40回日本磁気共鳴医学会大会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  437. 膵粘液性嚢胞腺癌の2例

    石口裕章、鈴木耕次郎、中道玲瑛、北野真利子、高田章、佐竹弘子、長縄慎二

    第72回東海総合画像医学研究会 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋市   Country:Japan  

  438. 仮想気管支鏡ナビゲーションの精度

    岸本真理子、岩野信吾、北野真利子、川上賢一、長縄慎二

    日本放射線医学会第152回中部地方会 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  439. 胸部3D-CTによる肺葉容積計測:全自動肺葉分割CADの精度

    岩野信吾、北野真利子、岸本真理子、川上賢一、長縄慎二、古池亘、松尾啓司

    日本放射線医学会第152回中部地方会 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  440. 巨大甲状腺腫を伴いI-131内用療法が著効を示したバセドウ病の2例

    土屋賢一、伊藤信嗣、岩野信吾、長縄慎二、加藤克彦

    日本核医学会第75回中部地方会 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  441. 「サーモサイフォン効果を具備した凍結プローブ」と「冷熱源」を用いた凍結治療装置の開発

    礒田治夫、竹原康雄、藤野 仁、曽根和哉、鈴木壮志、宮崎光司

    日本IVR学会第33回中部地方会 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  442. 胆道出血で発症した特発性肝動脈瘤破裂に対して塞栓術を施行した1例

    兵藤良太、高田 章、川上賢一、森 芳峰、鈴木耕次郎、長縄慎二、神岡祐子、小屋敏也

    日本IVR学会第33回中部地方会 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  443. Excluder留置時にメインボディーからtype3 エンドリークを認めた腹部大動脈瘤の1例

    鈴木耕次郎、小山明男、上遠野由紀、錦見尚道、長縄慎二

    日本IVR学会第33回中部地方会 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  444. 中部胆管から壁外に一塊状の腫瘤を形成した充実腺癌の1例

    古橋尚博、鈴木耕次郎、高田 章、長縄慎二

    第26回日本腹部放射線研究会 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪府   Country:Japan  

  445. 同時多発肺癌に対する仮想3Dマージン法を用いた手術計画

    岩野信吾、長縄慎二、宇佐見範恭、横井香平

    第2回Advanced CT・MR研究会 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  446. 拡散強調によらない脳幹神経束の描出の試み

    ト蔵公紀、長縄慎二、山崎雅弘、川井 恒、櫻井康雄、石橋一都、森美奈子、榊原勝浩、中野智、松岡祐樹、安藤康生、小西伊佐美、丸山裕輝

    第2回Advanced CT・MR研究会 

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    Event date: 2012.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  447. Optimal blood sampling location of the left adrenal vein in adrenal venous sampling. International conference

    TAKADA AKIRA,SUZUKI KOJIRO,MORI YOSHINE,KAWAKAMI KENICHI,OKOCHI YOSHIYUKI,HYODO RYOTA, NAGANAWA SHINJI

    APCCVIR2012JSIR&ISIR 

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    Event date: 2012.5 - 2012.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  448. Estimation of perilymph enhancement after intrarympanic administration of Gd-DTPA by fast T1-mapping with dual flip angle 3D-spoiled gradient echo sequence. International conference

    Naganawa S, Yamazaki M, Kawai H, Nakashima T

    ISMRM 20th Annual Meeting and Exhibition 

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    Event date: 2012.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  449. Fast T1-mapping用 3D-GREシークエンスによる鼓室内Gd投与後の造影効果推定

    長縄慎二、山崎 雅弘、川井 恒、中島 務

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  450. 画像表示アプリケーションの業務利用におけるThin clientシステムの事前評価

    坂上弘祐、吉田昌史、増澤高、川井恒:、長縄慎二、深津博

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  451. 仮想気管支鏡CADの精度

    岩野信吾、宇佐美範恭、横井香平、長縄慎二

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  452. 仮想気管支鏡CADの精度

    岩野信吾、古池亘、川上賢一、北野真利子、松尾啓司、長縄慎二

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  453. 乳腺の腹臥位MRIと背臥位CTにおける病変の移動

    佐竹弘子、石垣聡子、木村麗子、川井恒、西尾明子、長縄慎二

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  454. FDG集積の低い充実型原発性肺癌の検討

    岩野信吾、加藤克彦、伊藤信嗣、土屋賢一、長縄慎二

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  455. 子宮頸癌の術前同時化学放射線治療―病理組織学的検討―

    久保田誠司、伊藤善之、中原理絵、牧紗代、岡田徹、石原俊一、長縄慎二、中黒匡人、中村栄男

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  456. 3D-CTによる気腫肺容積測定:肺癌術後合併症との相関

    川上賢一、岩野信吾、長縄慎二、橋本直純、長谷川好規、宇佐美範恭、横井香平

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  457. 乳腺MRIにおける背景乳腺の造影効果の予測

    河村綾希子、佐竹弘子、石垣聡子、木村麗子、川井恒、長縄慎二、池田充、島本佳寿広

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  458. 背景乳腺の造影効果が乳癌術前MRI に与える影響について

    沼波悟古、石垣聡子、佐竹弘子、木村麗子、河村綾希子、川井恒、長縄慎二

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  459. 仮想3Dマージン法を用いた肺区域切除術シミュレーション

    岩野信吾、宇佐美範恭、横井香平、長縄慎二

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  460. 十二指腸乳頭部癌の画像診断

    高田章、鈴木耕次郎、石垣聡子、伊藤茂樹、長縄慎二

    第71回日本医学放射線学会総会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  461. Virtual Bronchoscopic Navigation(VBN)による気管支鏡下生検経路の診断精度

    岸本真理子、岩野信吾、長縄慎二

    第71回東海総合画像医学研究会 

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    Event date: 2012.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  462. MR imaging of Meniere's disease; Objective diagnosis of endolymphatic hydrops by iv-Gd International conference

    NAGANAWA SHINJI

    17th KSMRM 

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    Event date: 2012.3 - 2012.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  463. Normal diameters of the Cochlear Nerve and Facial Nerve on 3D-CISS at 3T. International conference

    Nakamichi Rei, Yamazaki Masahiro, Kawai Hisashi, Naganawa Shinji

    ECR 

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    Event date: 2012.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  464. Supplemental value of diffusion weighted whole body imaging with background body signal suppression (DWIBS) technique to whole body magnetic resonance imaging in detection of bone metastases from thyroid cancer. International conference

    Sakurai Yusuke, Kawai Hisashi, Iwano Shingo, Ito Shinji, Ogawa Hiroshi, Naganawa Shinji

    ECR2012. 

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    Event date: 2012.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  465. 仮想3Dマージン法による肺癌区域切除術の妥当性の検討

    岩野信吾、古池 亘、川上賢一、北野真利子、岸本真理子、長縄慎二、宇佐美範恭、横井香平

    日本放射線医学会第151回中部地方会  

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    Event date: 2012.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  466. 子宮頸癌術前同時化学放射線療法の病理組織学的検討

    久保田誠司、伊藤善之、中原理絵、牧 紗代、岡田 徹、石原俊一、長縄慎二、中黒匡人、中村栄男

    日本放射線医学会第151回中部地方会  

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    Event date: 2012.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  467. 中部胆管から発生したSolid adenocarcinomaの1例

    古橋尚博、鈴木耕次郎、高田 章、長縄慎二、江畑智希、下山芳江

    日本放射線医学会第151回中部地方会  

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    Event date: 2012.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  468. 膵癌との鑑別が難しかった膵サルコイドーシスの1例

    矢田匡城、 鈴木耕次郎、北野真利子、高田 章、長縄慎二、宮田友子、高橋 祐

    日本放射線医学会第151回中部地方会  

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    Event date: 2012.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  469. 3D-CTによる肺気腫評価と肺癌術後合併症との相関

    川上賢一、岩野信吾、長縄慎二、橋本直純、長谷川好規、宇佐美範恭、横井香平

    日本放射線医学会第151回中部地方会  

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    Event date: 2012.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  470. 腎細胞癌のPET ― F-18 FDGとC-11メチオニンの比較

    伊藤信嗣、岩野信吾、長縄慎二 、加藤克彦 、松尾啓司

    日本核医学会第74回中部地方会 

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    Event date: 2012.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  471. 溶解困難なSMA血栓症に対し、マイクロバルーンカテーテルで血栓除去を行った1例

    森 芳峰、高田 章、鈴木耕次郎、長縄慎二

    日本IVR学会第32回中部・第31回関西合同地方会 

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    Event date: 2012.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪市   Country:Japan  

  472. 背景乳腺の造影効果が乳癌術前MRIに与える影響について

    沼波悟古、石垣聡子、佐竹弘子、木村麗子、河村綾希子、川井 恒、長縄慎二

    第21回日本乳癌画像研究会 

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    Event date: 2012.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  473. Estimation of perilymph enhancement after intrarympanic administration of Gd-DTPA by fast T1-mapping with dual flip angle 3D-spoiled gradient echo sequence. International conference

    NAGANAWA SHINJI, YAMAZAKI MASAHIRO, KAWAI HISASHI, NAKASHIMA TSUTOMU

    International Society of Magnetic Resonance in Medicine (ISMRM) 20th Annual Meeting and Exhibition 

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    Event date: 2012.2 - 2012.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  474. Virtual Bronchoscopic Navigation(VBN)による気管支鏡下生検経路の診断精度

    岸本真理子、岩野信吾、長縄慎二

    第71回東海総合画像医学研究会 

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    Event date: 2012.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  475. Distribution of gadolinium contrast agent in cochlear perilymph: Comparison of intratympanic and intravenous gadolinium injection. International conference

    YAMAZAKI MASAHIRO, NAGANAWA SHINJI, KAWAI HISASHI, NAKASHIMA TSUTOMU

    RSNA 2011 

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    Event date: 2011.11 - 2011.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  476. Difference of Diagnostic Accuracy in the Detection of Acute Cerebral Infarction Lesions on Brain CT: Comparison of Liquid Crystal Display (LCD) Calibrated with the Gray Scale Display Function (GSDF) and Gamma 2.2 in iPad International conference

    YOSHIMURA KUMIKO, NIHASHI TAKASHI, ANDO YOSHIO, IKEDA MITSURU, NAGANAWA SHINJI

    RSNA 2011 

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    Event date: 2011.11 - 2011.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  477. Detection of urinary tract cancer by 11C-choline PET/CT. International conference

    KATO KATSUHIKO, ABE SHINJI, SASSA NAOTO, IKEDA MITSURU, SHIMAMOTO KAZUHIRO, NAGANAWA SHINJI

    RSNA 2011 

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    Event date: 2011.11 - 2011.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  478. Distribution of gadolinium contrast agent in cochlear perilymph: Comparison of intratympanic and intravenous gadolinium injection. International conference

    Yamazaki M, Naganawa S, Kawai H, Nakashima T

    RSNA2011 

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    Event date: 2011.11 - 2011.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  479. 子宮頚癌術後膣断端再発に対する放射線治療成績

    中原理絵、牧 紗代、久保田誠司、岡田 徹、石原俊一、伊藤善之、長縄慎二、堀川よしみ、奥田隆仁

    日本放射線腫瘍学会第24回学術大会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  480. 追跡調査精度と予後~非小細胞肺癌の場合~

    石原俊一、中原理絵、牧紗代、久保田誠司、岡田徹、伊藤善之、長縄慎二

    日本放射線腫瘍学会第24回学術大会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  481. 心臓内に発生した肉腫に対する炭素線治療

    岡田 徹、伊藤善之、久保田誠司、牧紗代、中原理絵、石原俊一、長縄慎二、今井礼子、辻比呂志、鎌田 正

    日本放射線腫瘍学会第24回学術大会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  482. 子宮頸癌の術前同時化学放射線治療-治療成績と有害事象を中心に-

    久保田誠司、、中原理絵、牧紗代、岡田徹、石原俊一、伊藤善之、長縄慎二

    日本放射線腫瘍学会第24回学術大会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  483. 前立腺癌密封小線源癌―放射線性直腸炎に関する検討

    牧 紗代、伊藤善之、石原俊一、久保田誠司、岡田 徹、中原理絵、長縄慎二、吉野 能、後藤百万、池田 充、伊藤淳二

    日本放射線腫瘍学会第24回学術大会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  484. 3D-CTによる肺癌の区域切除術シミュレーション:3Dマージン重ね合わせ法

    岩野信吾、宇佐美範恭、横井香平、古池亘、松尾啓司、長縄慎二

    第52回日本肺癌学会総会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  485. 3D-CTによる肺癌の区域切除術シミュレーション:3Dマージン重ね合わせ法

    岩野信吾、宇佐美範恭、横井香平、古池亘、松尾啓司、長縄慎二

    第52回日本肺癌学会総会 

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    Event date: 2011.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  486. FDG-PETで偽陰性を示した充実型原発性肺癌の検討

    岩野信吾 伊藤信嗣 加藤克彦 長縄慎二

    第51回日本核医学会学術総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば   Country:Japan  

  487. 分化型甲状腺癌に対するI-131アブレーションと同時施行したFDG-PET:治療後のサイログロブリン値の変化

    岩野信吾 伊藤信嗣 土屋賢一 加藤克彦 長縄慎二

    第51回日本核医学会学術総会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば   Country:Japan  

  488. 膵腺房細胞癌の多相造影CT 所見

    沼波悟古、鈴木耕次郎、伊藤茂樹、高田 章、森 芳峰、安藤嘉朗、長縄慎二

    第47回日本医学放射線学会 秋季臨床大会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:下関   Country:Japan  

  489. Comparison of FLT-PET/CT and FDG-PET/CT in detection of metastases of differentiated thyroid cancer. International conference

    TSUCHIYA KENICHI,KATO KATSUHIKO,IWANO SHINGO,OTA NAOTOSHI,ITO SINJI,NAGANAWA SHINJI

    EANM'2011 

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    Event date: 2011.10

    Language:English   Presentation type:Oral presentation (general)  

  490. Detection of urinary tract cancer by 11C-choline PET/CT. International conference

    KATO KATSUHIKO, ABE SHINJI, OTA NAOTOSHI, TSUCHIYA KENICHI, SUEZAWA SHOTARO, SASSA NAOTO, IKEDA MITSURU, SHIMAMOTO KAZUHIRO, NAGANAWA SHINJI

    EANM'2011 

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    Event date: 2011.10

    Language:English   Presentation type:Oral presentation (general)  

  491. Estimation of regional cerebral blood flow using I-123 IMP without any blood sampling: A new method that can be the substitution of O-15 water PET autoradiography method. International conference

    ABE SHINJI, KATO KATSUHIKO, TAKAHASHI YOSHITAKE, YAMASHITA MASATO, FUJITA NAOTOSHI, OHTA NAOTOSHI, TADOKORO MASANORI, NAGANAWA SHINJI

    EANM'2011 

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    Event date: 2011.10

    Language:English   Presentation type:Oral presentation (general)  

  492. Evaluation of I-131 radioiodine therapy for bone metastases of differentiated thyroid carcinoma by F-18 FDG-PET/CT. International conference

    ITO SHINJI,IWANO SHINGO,KATO KATSUHIKO,NAGANAWA SHINJITOSHI,ITO SINJI,NAGANAWA SHINJI

    EANM'2011 

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    Event date: 2011.10

    Language:English   Presentation type:Oral presentation (general)  

  493. Comparison of 18F-fluoride PET/CT 18F-FDG PET/CT,and bone scintigraphy detction of bone metastases of differentiated thyroid cancer. International conference

    OTA NAOTOSHI,KATO KATSUHIKO,IWANO SHINGO,ITO SINJI,TSUCHIYA KENICHI,OKOUCHI YOSHIYUKI,OKADA YUMIKO,NAGANAWA SHINJI

    EANM'2011 

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    Event date: 2011.10

    Language:English   Presentation type:Oral presentation (general)  

  494. 内耳MRIの撮像と読影に役立つ知識;内リンパ水腫の診断を中心に

    長縄慎二

    第47回なにわ臨床画像研究会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  495. 内耳MRIの撮像と読影に役立つ知識;内リンパ水腫の診断を中心に

    長縄慎二

    第47回なにわ臨床画像研究会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  496. 3T装置における頚髄の拡散強調像 - multi-shot、single-shotでのEPI-DWIの比較 -

    川井 恒、長縄慎二、山崎雅弘、櫻井康雄、丸山克也

    第39回日本磁気共鳴学会大会 

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    Event date: 2011.9 - 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  497. 3T-MRI における4chEarCoil と32chHeadCoil によるSNR の比較

    安藤康生、櫻井康雄、石橋一都、河村美奈子、卜蔵公紀、榊原勝浩、駒田友美、長縄慎二

    第39回日本磁気共鳴学会大会 

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    Event date: 2011.9 - 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  498. 等倍量ガドリニウム造影剤静注による内リンパ水腫検出の至適待ち時間の検討;3.5, 4.0, 4.5 時間の比較

    長縄慎二、山崎雅弘、川井恒、中島務

    第39回日本磁気共鳴学会大会 

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    Event date: 2011.9 - 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  499. Readout segmented EPI( rs-EPI; RESOLVE)による拡散強調画像

    櫻井康雄、長縄慎二、川井恒、石橋一都、河村美奈子、榊原勝浩、松岡祐樹、安藤康生、ト蔵公紀、米田和夫、丸山克也、David Porter

    第39回日本磁気共鳴学会大会 

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    Event date: 2011.9 - 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  500. 3T MRIでCISSを用いて撮像した蝸牛神経および顔面神経の正常径

    中道玲瑛、山崎雅弘、川井恒、長縄慎二

    第39回日本磁気共鳴学会大会 

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    Event date: 2011.9 - 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  501. ガドリニウム造影剤鼓室内投与24時間後と静脈内投与4時間後での蝸牛基底回転と上位回転造影効果の検討

    山崎雅弘、長縄慎二、川井恒、中島務

    第39回日本磁気共鳴学会大会 

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    Event date: 2011.9 - 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  502. 3T-MRI における4chEarCoil と32chHeadCoil によるSNR の比較

    安藤康生、櫻井康雄、石橋一都、河村美奈子、卜蔵公紀、榊原勝浩、駒田友美、長縄慎二

    第39回日本磁気共鳴学会大会 

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    Event date: 2011.9 - 2011.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州   Country:Japan  

  503. Estimation of cerebral blood flow using 123I-IMP acquisition data without any blood sampling. International conference

    Society of Nuclear Medicine 58th Annual Meeting

    Society of Nuclear Medicine 58th Annual Meeting 

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    Event date: 2011.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  504. 胸腔内chronic expanding hematomaの1例

    河村綾希子、伊藤信嗣、岩野信吾、長縄慎二

    第70回東海総合画像医学研究会 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  505. 脳機能MR画像解析 3T MR装置における施設内及び施設間の再現性の検証

    竹田和真、礒田治夫、福山篤司、小山修司、櫻井康雄、長縄慎二

    第70回東海総合画像医学研究会 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  506. 片頭痛・めまい・突発性難聴の臨床ーその周辺をめぐってー めまい、突発性難聴の画像診断

    長縄慎二

    第14回日本病院脳神経外科学会 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:松山   Country:Japan  

  507. ジャーミノーマのMethionine/FDG-PET を用いた検討用いた検討

    大河内慶之、岡田有美子、二橋尚志、加藤克彦、長縄慎二 安藤嘉朗、藤井正純、前澤 聡、竹林重典

    日本核医学会第73回中部地方 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  508. 背景乳腺の造影効果が乳癌術前MRI に与える影響について

    石垣聡子、佐竹弘子、木村麗子、河村綾希子、川井 恒、長縄慎二

    日本医学放射線学会第150回中部地方会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  509. 膠芽腫と脳原発悪性リンパ腫の鑑別診断 Methionine/FDG-PET を用いた検討

    岡田有美子、大河内慶行、二橋尚志、加藤克彦、長縄慎二 安藤嘉朗、藤井正純、前澤 聡、竹林重典

    日本核医学会第73回中部地方 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  510. 肺分画症に対して術前の塞栓術を施行した1 例

    川上賢一、高田 章、鈴木耕次郎、森 芳峰、長縄慎二、宇佐見範恭、立松明子

    日本IVR学会第31回中部地方会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  511. 3D-CT による肺癌区域切除術のシミュレーション

    岩野信吾、長縄慎二、宇佐美範恭、横井香平

    日本医学放射線学会第150回中部地方会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  512. 子宮頚癌の術前化学放射線治療-その1 遠隔成績について-

    久保田誠司、中原理絵、牧 紗代、岡田 徹、石原俊一、伊藤善之、長縄慎二

    日本医学放射線学会第150回中部地方会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  513. 前立腺密封小線源治療による有害事象について-放射線直腸炎に関する検討-

    牧 紗代、伊藤善之、久保田誠司、石原俊一、岡田 徹、中原理絵、長縄慎二、吉野 能、後藤百万、伊藤淳二、池田 充

    前立腺密封小線源治療による有害事象について-放射線直腸炎に関する検討- 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  514. 心臓内に発生した肉腫に対する炭素線治療

    岡田 徹、久保田誠司、牧 紗代、中原理絵、石原俊一、伊藤善之、長縄慎二、今井礼子、辻比呂志、鎌田 正

    日本医学放射線学会第150回中部地方会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  515. 膵管内乳頭粘液性腺癌を疑った粘液癌成分を伴った膵腺房細胞癌の1例

    沼波悟古、 鈴木耕次郎、 高田 章、 森 芳峰、 長縄慎二、 伊藤茂樹、竹田 伸、下山芳江

    第25回日本腹部放射線研究会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  516. 新生児に生じた膵芽腫の1例

    高田章、佐竹弘子、鈴木耕次郎、長縄慎二、小川浩、金子健一朗、小野靖之、佐藤啓、安藤久實

    第25回日本腹部放射線研究会 

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    Event date: 2011.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  517. One's own name is connected to consciousness. International conference

    NAKANE TOSHIKI,MIYAKOSHI MAKOTO,NAKAI TOSHIHARU,NAGANAWA SHINJI

    The 15th annual meeting of the ASSC 

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    Event date: 2011.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  518. 大動脈解離による腹部分枝動脈狭窄に対してステント治療を施行した4例

    鈴木耕次郎、大河内慶行、川上賢一、土屋賢一、高田 章、森 芳峰、長縄慎二

    第40回日本IVR学会 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:青森市文化会館   Country:Japan  

  519. 一般臨床における静注Gd造影によるメニエール病診断;いま放射線科医が知っておくべきこと

    長縄慎二、中島 務、川井 恒、山崎雅弘

    第70回日本医学放射線学会総会web開催 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  520. 小型肺腺癌の病理学的予後因子とダイナミックCTの造影パターンとの関係

    岩野 信吾、古池 亘、清水 真利子、松尾 啓司、長縄 慎二、下山 芳江

    第70回日本医学放射線学会総会web開催 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  521. 胸部3D-CTによる呼吸機能解析:画像スライス厚の影響

    清水 真利子、岩野 信吾、古池 亘、松尾 啓司、長縄 慎二

    第70回日本医学放射線学会総会web開催 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  522. 乳房温存術・術中放射線照射による有害事象と美容評価 -短期評価での検討-

    伊藤 淳二、伊藤 善之、石原 俊一、平澤 直樹、牧 紗代、久保田 誠司、池田 充、 長縄 慎二

    第70回日本医学放射線学会総会web開催 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  523. 多相造影CTにおける自己免疫性膵炎の主膵管壁濃染所見;膵癌、慢性膵炎との比較

    河合 雄一、鈴木 耕次郎、伊藤 茂樹、高田 章、森 芳峰、長縄 慎二

    第70回日本医学放射線学会総会web開催 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  524. MMG・US・MRI拡散強調像によるダイナミックMRIの乳腺造影効果の予測

    佐竹 弘子、石垣 聡子、木村 麗子、川井 恒、島本 佳寿広、長縄 慎二

    第70回日本医学放射線学会総会web開催 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  525. 吸気・呼気3D-CTによる肺葉容積計測

    岩野 信吾、松尾 啓司、古池 亘、清水 真利子、長縄 慎二、橋本 直純、今泉 和良、長谷川 好規、宇佐美 範恭、横井 香平 

    第70回日本医学放射線学会総会web開催 

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    Event date: 2011.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web開催   Country:Japan  

  526. Anatomical details in brainstem and cisterns revealed by RESOLVE with unidirectional MPG; comparison with single-shot EPI diffusion weighted image International conference

    NAGANAWA SHINJI,KAWAI HISASHI,YAMAZAKI MASAHIRO

    The 19th anual meeting of international society of magnetic resonance in medicine 

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    Event date: 2011.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  527. Investigating the neural base of hearing one's own name by fMRI International conference

    NAKANE TOSHIKI,MIYAKOSHI MAKOTO,NAKAI TOSHI,NAGANAWA SHINJI

    The 19th anual meeting of international society of magnetic resonance in medicine 

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    Event date: 2011.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  528. Autoimmune pancreatitis; diagnostic ability of main pancreatic duct wall enhancement sign on multiphase contrast-enhanced CTimages using a multislice CT scanner International conference

    KAWAI YUICHI , SUZUKI KOJIRO, ITOH SHIGEKI, TAKADA AKIRA, MORI YOSHINE , NAGANAWA SHINJI

    ECR2011 

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    Event date: 2011.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  529. Correlation between enhanced dynamic CT findings and pathological prognostic factors of small lung adenocarcinoma tumors. International conference

    IWANO SHINGO,KOIKE WATARU,MATSUO KEIJI, OKADA THORU,NAGANAWA SHINJI

    ECR2011 

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    Event date: 2011.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  530. 吸気、呼気3D-CTによる肺機能評価

    岩野信吾、清水真利子、川上賢一、古池 亘、松尾啓司、長縄慎二、橋本直純、今泉和良、長谷川好規

    日本放射線学会第149回中部地方会 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:津地区医師会館   Country:Japan  

  531. 乳房温存手術・術中放射線照射による有害事象と美容評価-短期評価での検討-

    伊藤淳二、久保田誠司、牧 紗代、平澤直樹、石原俊一、伊藤善之、長縄慎二、佐藤成憲、澤木正孝、今井常夫

    日本放射線学会第149回中部地方会 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:津地区医師会館   Country:Japan  

  532. CTを利用した子宮頸癌腔内照射の治療システムの構築に向けて

    平澤直樹、伊藤善之、中原理絵、久保田誠司、牧 紗代、石原俊一、長縄慎二

    日本放射線学会第149回中部地方会 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:津地区医師会館   Country:Japan  

  533. 子宮頚癌術後膣断端再発に対する放射線治療成績

    中原理絵、伊藤善之、久保田誠司、牧 紗代、平澤直樹、石原俊一、長縄慎二

    日本放射線学会第149回中部地方会 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:津地区医師会館   Country:Japan  

  534. 膵管内乳頭粘液性腺癌との鑑別が難しかった粘液癌を伴った膵腺房細胞癌の一例

    沼波悟古、鈴木耕次郎、森芳峰、長縄慎二、伊藤茂樹、竹田伸、下山芳江

    日本放射線学会第149回中部地方会 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:津地区医師会館   Country:Japan  

  535. 甲状腺癌の骨転移診断におけるF-18 NaF PET/CT、骨シンチグラフィ、F-18 FDG PET/CTの比較

    太田尚寿、岩野信吾、伊藤信嗣、土屋賢一、大河内慶行、岡田有美子、長縄慎二、山下雅人、亀山裕司、篠田正樹、青山裕一、加藤克彦

    日本核医学会第72回中部地方会 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:津地区医師会館   Country:Japan  

  536. 鼓室型グロムス腫瘍に対して術前のTAEを施行した1例

    土屋賢一、高田 章、鈴木耕次郎、森 芳峰、長縄慎二、曽根三千彦、松明子

    日本IVR学会第30回中部地方会 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:津地区医師会館   Country:Japan  

  537. 内リンパ水腫をみる

    長縄慎二

    市民公開講座 厚生労働科学研究・研究成果等普及啓発事業による成果発表 耳からくるめまい、ふらつき、耳鳴ー生活習慣との関連ー 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ウインク愛知   Country:Japan  

  538. 内リンパ水腫をみる International conference

    長縄慎二

    市民公開講座 厚生労働科学研究・研究成果等普及啓発事業による成果発表 耳からくるめまい、ふらつき、耳鳴ー生活習慣との関連ー 

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    Event date: 2011.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  539. 内耳MRIの現状と展望 International conference

    長縄慎二

    第13回山形めまい研究会 

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    Event date: 2011.1

    Language:English   Presentation type:Oral presentation (general)  

    Venue:山形   Country:Japan  

  540. 内耳MRIの現状と展望

    長縄慎二

    第13回山形めまい研究会 

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    Event date: 2011.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山形   Country:Japan  

  541. Extrapulmonary lymphangioleiomyomatosis(LAM)を伴う腎臓血管筋脂肪腫の2例

    矢田匡城、高田 章、森 芳峰、長縄慎二

    第69回東海総合画像医学研究会 

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    Event date: 2011.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  542. Comparison of I-123 IMP SPECT, F-18 FDG PET/CT, and F-18 DOPA PET/CT in Detection of Primary and Metastatic Lesions of Cutaneous Malignant Melanoma.al Findings. International conference

    KATO KATSUHIKO,ABE SHINJI,TUCHIYA KENICHI,IKEDA MITSURU,SHIMAMOTO KAZUHIRO,NAGANAWA SHINJI

    RSNA2010 

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    Event date: 2010.11 - 2010.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  543. Diagnostic MR Imaging of Meniere's Disease by Intravenous Gd-DTPA in Routine Clinical Setting: What Radiologists Should Know about the Disease, Procedure, Anatomy, and Abnormal Findings. International conference

    NAGANAWA SHINJI, NAKASHIMA TSUTOMU, KAWAI HISASHI

    RSNA2010 

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    Event date: 2010.11 - 2010.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  544. High-Rate Lossless Compression Algorithm (Standard Optimized Compression [SOC]) Implemented DICOM Viewer: Technological Validation and Clinical Impact Evaluation. International conference

    FUKATSU HIROSHI,TOMINAGA MOTOKI,NAGANAWA SHINJI,OSADA MASAKAZU

    RSNA2010 

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    Event date: 2010.11 - 2010.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  545. Contrast Effect of the Cochlear Perilymph on 3D-FLAIR after Two Different Gadolinium Contrast Agent Administration Techniques at 3 Tesla: Comparison of Intratympanic and Intravenous Gadolinium Injection.TPA in Routine Clinical Setting: What Radiologists Should Know about the Disease, Procedure, Anatomy, and Abnormal Findings. International conference

    YAMAZAKI MASAHIRO,NAGANAWA SHINJI,TAGAYA MITSUHIKO,NAKASHIMA TSUTOMU

    RSNA2010 

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    Event date: 2010.11 - 2010.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  546. Diffusion-weighted Imaging of Breast Masses: Comparison of the Diagnostic Performance Using Apparent Diffusion Coefficient ParametersTPA in Routine Clinical Setting: What Radiologists Should Know about the Disease, Procedure, Anatomy, and Abnormal Findings. International conference

    HIRANO MAKI,SATAKE HIROKO,ISHIGAKI SATOKO,IKEDA MITSURU,KAWAI HISASHI,NAGANAWA SHINJI

    RSNA2010 

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    Event date: 2010.11 - 2010.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  547. 乳房温存手術・術中放射線照射の安全性と有効性に関する第1/2 相試験

    伊藤善之、石原俊一、平澤直樹、久保田誠司、牧 紗代、中原理絵、長縄慎二

    日本放射線腫瘍学会 第23回学術大会 

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    Event date: 2010.11

    Language:Japanese  

    Country:Japan  

  548. 非小細胞肺癌に対する放射線治療成績

    石原俊一、中原理絵、牧紗代、久保田誠司、平澤直樹、伊藤善之、長縄慎二

    日本放射線腫瘍学会 第23回学術大会 

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    Event date: 2010.11

    Language:Japanese  

    Country:Japan  

  549. Image Evaluation of Endolymphatic Space in Patients with Meniere's Disease. International conference

    Nakashima T, Naganawa S, Sone M, Teranishi M

    Sixth International Symposium on Meniere's Disease and Inner Ear Disorders 

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    Event date: 2010.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  550. 皮膚原発悪性黒色腫と転移巣の検出における18F-FDG PET/CTと18F-DOPA PET/CTの比較

    加藤克彦、阿部真治、岩野信吾、二橋尚志、太田尚寿、土屋賢一、伊藤信嗣、長縄慎二

    第50回日本核医学会学術総会 

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    Event date: 2010.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大宮   Country:Japan  

  551. 分化型甲状腺癌ablation時のFDG-PETによる残存病巣の検索

    第50回日本核医学会学術総会 

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    Event date: 2010.11

    Language:Japanese  

  552. 今、人類が手に入れた画像診断モダリティのUp to Date

    長縄慎二

    安城市医師会研修会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:安城   Country:Japan  

  553. Noninvasive estimation of regional cerebral blood flow using 123I-IMP acquisition data. International conference

    Abe S, Kato K,Takahashi Y, Yamashita M, Fujita N, Ohta N, Kajita Y, Naganawa S

    2010 Nagoya-Yonsei University Reserch Exchange Meetings on Health Siences 

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    Event date: 2010.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  554. Estimation of the arterial blood sample activity using multiple regression analysis (Monte Carlo simulation) with time series of 123I-IMP acquisition data. International conference

    Abe S, Kato K, Takahashi Y, Ota N, Naganawa S

    EANM2010 

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    Event date: 2010.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  555. Comparison of I-123 IMP SPECT, F-18 FDG PET/CT, and F-18 DOPA PET/CT in detection of primary and metastatic lesions of cutaneous malignant melanoma International conference

    EANM'10 

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    Event date: 2010.10

    Language:English  

  556. 名前に対する注意は前頭葉内側の脳活動に反映される

    中根俊樹、宮腰誠、中井敏晴、長縄慎二

    第38回日本磁気共鳴医学会大会 

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    Event date: 2010.9

    Language:Japanese  

    Country:Japan  

  557. 拡散強調画像におけるADC パラメーターの比較による乳腺腫瘤の良悪性診断

    平野真希、佐竹弘子、石垣聡子、川井恒、池田充、長縄慎二

    第38回日本磁気共鳴医学会大会 

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    Event date: 2010.9

    Language:Japanese  

    Country:Japan  

  558. 鼓室内ガドリニウム造影剤注入による内リンパ水腫描出; 2D-real IR 法と3D-real IR 法の比較

    長縄慎二、山崎雅弘、川井恒、中島務

    第38回日本磁気共鳴医学会大会 

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    Event date: 2010.9

    Language:Japanese  

    Country:Japan  

  559. Parallel imaging 再構成法がADC 値与える影響に関する検討

    櫻井康雄、長縄慎二、川井恒、石橋一都、河村美奈子、榊原勝浩、駒田友美、安藤康生、ト蔵公紀、米田和夫

    第38回日本磁気共鳴医学会大会 

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    Event date: 2010.9

    Language:Japanese  

    Country:Japan  

  560. 3T 装置における頚髄の拡散強調像 BLADE-DWI とEPI-DWI での比較

    川井恒、長縄慎二、櫻井康雄、丸山克也

    第38回日本磁気共鳴医学会大会 

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    Event date: 2010.9

    Language:Japanese  

    Country:Japan  

  561. 迷走神経に由来する神経鞘腫の1例

    中道玲瑛、川井 恒、長縄慎二

    中道玲瑛、川井 恒、長縄慎二 

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    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  562. 最近の画像診断

    長縄慎二

    愛知県保険医協会 内科臨床研究会 

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    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  563. 大腸がんの肝転移に対する化学療法効果判定 FDG-PETを用いて

    富家未来、二橋尚志、長縄慎二、加藤克彦、石黒成冶、上原圭介

    第68回東海総合画像医学研究プログラム 

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    Event date: 2010.7

    Language:Japanese  

    Country:Japan  

  564. トリプルネガティブ乳癌MRI~拡散強調像や1HMRSを中心に~

    石垣聡子、佐竹弘子、川井 恒、今井常夫、角田信行、川村麻里子、長縄慎二

    第18回日本乳癌学会学術総会 

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    Event date: 2010.6

    Language:Japanese  

    Country:Japan  

  565. 乳腺腫瘤に対する超音波エラストグラフィとMRI拡散強調画像の良悪性診断能について

    佐竹弘子、西尾明子、石垣聡子、池田 充、今井常夫、長縄慎二

    第18回日本乳癌学会学術総会 

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    Event date: 2010.6

    Language:Japanese  

    Country:Japan  

  566. 乳房温存を目的とする術前化学療法の効果予測

    川村麻里子、佐竹弘子、西尾明子、石垣聡子、長縄慎二、澤木正孝、下山芳江

    第18回日本乳癌学会学術総会 

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    Event date: 2010.6

    Language:Japanese  

    Country:Japan  

  567. 頭頸部領域

    長縄慎二

    第10回3T MR研究会 

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    Event date: 2010.6

    Language:Japanese  

    Country:Japan  

  568. 肺葉分割CADを用いた3D-CTによる肺機能検査(第1報)

    岩野信吾、松尾啓司、古池 亘、長縄慎二

    日本医学放射線学会第148回中部地方会 

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    Event date: 2010.6

    Language:Japanese  

    Country:Japan  

  569. 子宮頸癌の根治的放射線治療成績

    久保田誠司、中原理絵、牧 紗代、平澤直樹、石原俊一、伊藤善之、長縄慎二、奥田隆仁、堀川よしみ

    日本医学放射線学会第148回中部地方会 

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    Event date: 2010.6

    Language:Japanese  

    Country:Japan  

  570. 非小細胞肺癌に対する放射線治療成績

    石原俊一、中原理絵、牧 紗代、久保田誠司、平澤直樹、伊藤善之、長縄慎二

    日本医学放射線学会第148回中部地方会 

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    Event date: 2010.6

    Language:Japanese  

    Country:Japan  

  571. 皮膚原発悪性黒色腫と転移巣の検出における&#8321;₈F-FDG PET/CTと&#8321;₈F-DOPA PET/CTの比較

    加藤克彦、阿部真治、岩野信吾、二橋尚志、太田尚寿、土屋賢一、伊藤信嗣、安藤嘉朗、小川 浩、山崎雅弘、河合雄一、大河内慶行、川上賢一、長縄慎二、横田憲二、富田 靖

    日本核医学会第71回中部地方会 

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    Event date: 2010.6

    Language:Japanese  

    Country:Japan  

  572. スマート静脈瘤に対してB-RTOが有効であった1例

    高田章、清水真利子、森 芳峰、鈴木耕次郎、太田豊裕、長縄慎二、神岡祐子、岡江俊二、岡田禎人

    日本IVR学会第29回中部地方会 

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    Event date: 2010.6

    Language:Japanese  

    Country:Japan  

  573. Foreign body granulomaと診断された腫瘤形成性膵炎の1例

    河合雄一、 鈴木耕次郎、 小川 浩、 太田豊裕、 長縄慎二、 伊藤茂樹、藤井 努

    第24回腹部放射線研究会 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  574. 特発性と考えられた肝内血腫の1例

    鈴木耕次郎、 森 芳峰、 太田豊裕、 長縄慎二、 伊藤茂樹、 野本周嗣

    第24回腹部放射線研究会 

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    Event date: 2010.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  575. Comparison of 123I-IMP SPECT, 18F-FDG PET/CT, and 18F-Dopa PET/CT in detection of uveal malignant melanoma. International conference

    Kato K, Abe S, Ikeda M, Iwano S, Terasaki H, Naganawa S

    Society of Nuclear Medicine 57nd Annual Meeting 

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    Event date: 2010.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  576. Hearing one's own name actives the medical frontal area? International conference

    Human Brain Mapping 2010 Annual Meeting 

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    Event date: 2010.6

    Language:English  

  577. Variation of language activation in patients with brain tumors demonstrated by fMRI. International conference

    Human Brain Mapping 2010 Annual Meeting 

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    Event date: 2010.6

    Language:English  

  578. 一般臨床家のための脳神経画像診断 現状と最近の話題;MRを中心に

    第27回MCRフォーラム 

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    Event date: 2010.6

    Language:Japanese  

    Country:Japan  

  579. 内耳MRI画像の進歩

    長縄慎二

    第111回日本耳鼻咽喉科学会総会・学術講演会 

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    Event date: 2010.5

    Language:Japanese  

    Country:Japan  

  580. Visualization of endolymphatic hydrops in the patients with Meniere's disease by intravvenous Gd-DTPA administration. International conference

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    Event date: 2010.5

    Language:English  

    Country:Japan  

  581. MR Spectroscopy of the breast cancer at 3.0-Tesla: Comparison between pre-and post- contrast administration. International conference

    Kawai H, Satake H, Ishigaki S, Sakurai Y, Kawamura M,, Matsuyama K, Naganawa S

    Joint Annual Meeting ISMRM-ESMRMB2010 

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    Event date: 2010.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Sweden  

  582. ホルモン受容体とHER2蛋白の発現による乳癌の病型分類と1HMRSを取り入れたMRI所見との比較検討

    佐竹弘子、石垣聡子、川井 恒、川村麻里子、戸谷麗子、平野真希、長縄慎二

    第69回日本医学放射線学会総会 

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    Event date: 2010.4

    Language:Japanese  

    Country:Japan  

  583. メニエール病患者での静注ガドリニウム造影による内リンパ水腫の描出

    長縄慎二、川井恒、中島務

    第69回日本医学放射線学会総会 

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    Event date: 2010.4

    Language:Japanese  

    Country:Japan  

  584. Ⅰ期肺腺癌の造影ダイナミックCTによる組織推定

    岩野信吾、古池 亘、松尾啓司、長縄慎二、下山芳江、岡田徹

    第69回日本医学放射線学会総会 

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    Event date: 2010.4

    Language:Japanese  

    Country:Japan  

  585. 膵管内乳頭粘膜性腫瘍(IPMN)由来浸潤癌の多相造影CT所見の検討

    鈴木耕次郎、伊藤茂樹、長坂徹郎、太田豊裕、長縄慎二

    第69回日本医学放射線学会総会 

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    Event date: 2010.4

    Language:Japanese  

    Country:Japan  

  586. 胆管内乳頭状腫瘍のCTの所見:マルチスライスCTの多相造影検査による検討

    小川 浩、伊藤茂樹、鈴木耕次郎、太田豊裕、長縄慎二

    第69回日本医学放射線学会総会 

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    Event date: 2010.4

    Language:Japanese  

    Country:Japan  

  587. 腸管に著明な集積を来した骨シンチグラフィの1例

    大河内慶行、岩野信吾、二橋尚志、伊藤信嗣、小川 浩、安藤嘉朗、中根俊樹、山崎雅弘、太田尚寿、河合雄一、平野真希、古池 亘、岡田有美子、川上賢一、土屋賢一、長縄慎二、加藤克彦、阿部真治

    日本核医学会第70回中部地方会 

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    Event date: 2010.2

    Language:Japanese  

  588. 膵癌のAppleby術前処置として総肝動脈塞栓術を施行した3例

    日本IVR学会 第28回中部・第27回関西合同地方会 

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    Event date: 2010.2

    Language:Japanese  

    Country:Japan  

    太田豊裕、鈴木耕次郎、森 芳峰、松島正哉、長縄慎二

  589. 転移性脳腫瘍に対する放射線治療の成績

    奥田隆二、櫻井悠介、浅野晶子、熊田倫、石原俊一、久保田誠司、伊藤淳二、伊藤善之、長縄慎二

    日本医学放射線学会第147回中部地方会 

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    Event date: 2010.2

    Language:Japanese  

  590. 金属冠による放射線治療時の口腔粘膜への影響について その1

    伊藤淳二、伊藤善之、平澤直樹、久保田誠司、石原俊一、牧 紗代、長縄慎二、五十嵐幸哲、下郷智弘、小幡 康、青山裕一、奥平訓康、野口由美子、都築 真、平松真理子、安藤篤、藤本 保、山本憲幸

    日本医学放射線学会第147回中部地方会 

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    Event date: 2010.2

    Language:Japanese  

    Country:Japan  

  591. 高齢者子宮頸癌の根治的放射線治療成績

    久保田誠司、伊藤善之、伊藤淳二、牧 紗代、平澤直樹、石原俊一、長縄慎二

    久保田誠司、伊藤善之、伊藤淳二、牧 紗代、平澤直樹、石原俊一、長縄慎二 

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    Event date: 2010.2

    Language:Japanese  

    Country:Japan  

  592. 小型肺腺癌の造影ダイナミックCT所見と進達度との関係

    岩野信吾、古池 亘、松尾啓司、長縄慎二、下山芳江

    日本医学放射線学会第147回中部地方会 

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    Event date: 2010.2

    Language:Japanese  

    Country:Japan  

  593. 診断が困難であった肝AMLの2例

    岡田有美子、小川 浩、佐竹弘子、太田豊裕、長縄慎二

    第67回東海総合画像医学研究会プログラム 

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    Event date: 2010.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  594. Susceptibility Weighted Imagingを用いた視床下核の直接的描出

    竹林成典、種井隆文、中原紀元、中坪大輔、前澤 聡、梶田泰一、長縄慎二

    第67回東海総合画像医学研究会プログラム  

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    Event date: 2010.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  595. F-18 FDG PET/CT in Pancreatic Tumors: Is the Differential Diagnosis between Pancreatic Cancer and Mass-forming Pancreatitis Possible? International conference

    Kato K, Abe S , Ikeda M, Itoh S ,Shimamoto K , Naganawa S

    RSNA2009 

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    Event date: 2009.11 - 2009.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  596. 3Tesla MR Imaging of Triple Negative Breast Cancer :Correlation with Pathologic Findings. International conference

    Ishigaki S, Satake H, Kawamura M, Kawai H, Naganawa S

    RSNA2009 

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    Event date: 2009.11 - 2009.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  597. Comparison of I-123 IMP SPECT, F-18 FDG PET/CT, and F-18 Dopa PET/CT in Detection of Uveal Malignant Melanoma. International conference

    Kato K ,Abe S , Nihashi T , Ikeda M, Terasaki H , Naganawa S

    RSNA2009 

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    Event date: 2009.11 - 2009.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  598. めまいと難聴の画像診断;基本から最近のMRの進歩まで

    長縄慎二

    第9回北海道臨床画像診断セミナー 

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    Event date: 2009.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道   Country:Japan  

  599. 半自動3D容積測定CADを用いた末梢型肺癌のdoubling time計測

    古池亘、岩野信吾、松尾啓司、長縄慎二

    第50回日本肺癌学会総会 

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    Event date: 2009.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  600. CADを使った3D-CT肺葉分割の初期的検討

    岩野信吾、松尾啓司、古池亘、長縄慎二

    第50回日本肺癌学会総会 

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    Event date: 2009.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  601. 粘液産生性胆管癌の一例

    小川浩、鈴木耕次郎、太田豊裕、長縄慎二、伊藤茂樹、江畑智希、下山芳江

    第45回日本医学放射線学会秋季臨床大会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:和歌山   Country:Japan  

  602. Comparison of I-123 IMP SPECT, F-18 FDG PET/CT and F-18 Dopa PET/CT in detection of uveal malignant melanoma. International conference

    Kato K, Abe S, Ikeda M,Terasaki H, Naganawa S

    EANM2009 

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    Event date: 2009.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Spain  

  603. 側頭骨画像

    長縄慎二

    第19回日本耳科学会総会・学術講演会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  604. 静注Gdによるメニエール病患者での内リンパ水腫の描出;倍量投与、3T、32チャンネルコイルでの遅延撮影

    長縄慎二、中島 務、川井 恒

    第37回日本磁気共鳴医学会大会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  605. 3Tにおける乳腺MRS   -造影前後での比較-

    川井恒、長縄慎二、川村麻里子、石垣聡子、佐竹弘子、河村美奈子、櫻井康雄、丸山克也

    第37回日本磁気共鳴医学会大会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  606. あなたの名前が呼ばれたら脳はどう活動するか-異なる注意状態が与える影響からの検討- 風景写真と模様のどちらの視覚刺激がfMRIで海馬活動を見やすいか -臨床での利用を念頭に-

    中根俊樹、宮腰 誠、中井敏晴、長縄慎二

    第37回日本磁気共鳴医学会大会 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  607. 分化型甲状腺癌に対するI-131 ablation時のFDG-PETの検討

    岩野信吾、加藤克彦、伊藤信嗣、二橋尚志、長縄慎二

    第49回日本核医学会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道   Country:Japan  

  608. 脈絡膜悪性黒色腫の診断における123I IMP SPECT, 18F FDG PET/CT, 18F Dopa PET/CTの比較

    加藤克彦、伊藤信嗣、岩野信吾、長縄慎二

    第49回日本核医学会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道   Country:Japan  

  609. 甲状腺癌に対するI-131内用療法: 骨転移病変におけるFDG集積の変化

    伊藤信嗣、岩野信吾、加藤克彦、長縄慎二

    第49回日本核医学会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北海道   Country:Japan  

  610. 転移性脳腫瘍に対する定位放射線治療の成績

    奥田隆仁、櫻井悠介、浅野晶子、熊田倫、島田秀樹、石原俊一、久保田誠司、伊藤淳二、伊藤善之、長縄慎二

    日本放射線腫瘍学会 第22回学術大会    日本医学物理学会 第98回学術大会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  611. 早期声門癌に対する多施設の遡及的調査

    日本放射線腫瘍学会 第22回学術大会 日本医学物理学会 第98回学術大会 

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    Event date: 2009.9

    Language:Japanese  

    Country:Japan  

  612. 悪性神経膠腫の放射線治療成績

    日本放射線腫瘍学会 第22回学術大会 日本医学物理学会 第98回学術大会 

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    Event date: 2009.9

    Language:Japanese  

    Country:Japan  

  613. 後腹膜嚢胞性腫瘤の2例

    川上賢一、森芳峰、長縄慎二、伊藤茂樹

    第66回東海総合画像医学研究会 

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    Event date: 2009.8

    Language:Japanese  

    Country:Japan  

  614. めまいと難聴の画像診断;基本から最近の進歩まで

    第240回Open Film Conference 

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    Event date: 2009.7

    Language:Japanese  

    Country:Japan  

  615. トリプルネガディブ乳癌のMRI所見の検討 International conference

    石垣聡子、佐竹弘子、西尾明子、川村麻里子、今井常男、小田高司、川井恒、下山芳江、長縄慎二

    第17回日本乳癌学会学術総会 

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    Event date: 2009.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  616. 外傷性持続勃起症に対して3.0Frシステムにて血管塞栓術を施行した1例

    日本IVR学会第27回中部地方会 

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    Event date: 2009.6

    Language:Japanese  

    Country:Japan  

  617. 粘液産生性胆管癌の1例

    日本医学放射線学会第146回中部地方会 

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    Event date: 2009.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  618. 悪性神経膠腫の放射線治療成績

    日本医学放射線学会第146回中部地方会 

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    Event date: 2009.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  619. 子宮頸癌化学放射線療法における卵巣機能温存の試み

    奥田隆仁、伊藤信嗣、松尾啓治、下川剛、小口秀紀、石原俊一、平澤直樹、伊藤善之、長縄慎二、青山裕一

    日本医学放射線学会第146回中部地方会 

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    Event date: 2009.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:浜松   Country:Japan  

  620. F-18 FDG-PET/CTを施行されたCarney triadの1例

    加藤克彦、古池 亘、戸谷麗子、平野真希、河合雄一、小川 浩、松島正哉、中根俊樹、大河内慶行、岡田有美子、川上賢一、安藤嘉朗、二橋尚志、長縄慎二、宇佐美範恭、横井香平

    日本核医学会第69回中部地方会 

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    Event date: 2009.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:浜松   Country:Japan  

  621. 腎細胞癌との鑑別が困難であった腎血管筋脂肪腫の1 例

    第23回腹部放射線研究会 

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    Event date: 2009.6

    Language:Japanese  

    Country:Japan  

  622. 膵のEnteric duplication cystの1 例

    第23回腹部放射線研究会 

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    Event date: 2009.6

    Language:Japanese  

    Country:Japan  

  623. Omparison of the Hippocampal Activation between Concrete and Abstract Pictures - A preliminary Evaluation for Clinical fMRI. International conference

    Nakane T, Nakai T, Miyakoshi M, Naganawa S, Matsuo K ,SH A Chen

    HBM2009 

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    Event date: 2009.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  624. Determination of Language Lateralitv using Functional MRI for the Patients with brain tumor -Comparison with WAIDA test International conference

    HBM2009(The 15th ANNUAL MEETING of the Organization for Human Brain Mapping) 

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    Event date: 2009.6

    Language:English  

  625. Growth Rate of Periphera Lung Cancers using Semi-automated Volumetric CAD with Multi-slice CT. International conference

    Koike W,Iwano S,Naganawa S

    2nd World Congress of Thoracic Imaging and Diagnosis in Chest Disease 

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    Event date: 2009.5 - 2009.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Spain  

  626. 3D visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA; optimization of 3D-real IR TSE sequence and utilization of 32ch head coil at 3T. International conference

    ISMRM2009 

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    Event date: 2009.4

    Language:English  

  627. Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma International conference

    ECR2009 

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    Event date: 2009.3

    Language:English  

  628. Predictive value for malignancy of suspicious breast masses of BI-RADS category 4-5 using ultrasound elastography and MRI diffusion-weighted imaging International conference

    ECR2009 

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    Event date: 2009.3

    Language:English  

  629. Virtual bronchoscopy-guided transbronchial lung biopsy in the diagnosis of peripheral lung cancer International conference

    ECR2009 

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    Event date: 2009.3

    Language:English  

  630. 婦人科腫瘍におけるF-18 FDG-PET後期像の有用性の検討

    伊藤信嗣、川瀬世津子、奥田隆仁、小口秀紀、田所匡典、加藤克彦、長縄慎二

    日本核医学会第68回中部地方会 

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    Event date: 2009.2

    Language:Japanese  

    Country:Japan  

  631. トリプルネガティブ乳癌のMRI所見の検討

    石垣聡子、佐竹弘子、西尾明子、川村麻里子、川井 恒、長縄慎二

    日本医学放射線学会第145回中部地方会 

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    Event date: 2009.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  632. 膵のEnteric duplication cystの1例

    太田尚寿、鈴木耕次郎、森 芳峰、長縄慎二、伊藤茂樹、竹田 伸

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    Event date: 2009.2

    Language:Japanese  

    Country:Japan  

  633. 早期声門癌に対する多施設による遡及的調査

    平澤直樹、伊藤善之、石原俊一、久保田誠司、伊藤淳二、長縄慎二、小幡康範、浅野晶子、小山一之、村尾豪之、野本由人、鈴木一徳、笹岡政宏、真下伸一、高井勝文

    日本医学放射線学会第145回中部地方会 

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    Event date: 2009.2

    Language:Japanese  

    Country:Japan  

  634. 食道癌に対する放射線療法の遡及的検討

    伊藤淳二、伊藤善之、石原俊一、平澤直樹、久保田誠司、長縄慎二

    日本医学放射線学会第145回中部地方会 

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    Event date: 2009.2

    Language:Japanese  

    Country:Japan  

  635. 異なった予後を示した子宮頚部小細胞癌の2例

    奥田隆仁、松尾啓司、浅野晶子、熊田 倫、河合通泰、石原俊一、伊藤善之、長縄慎二

    日本医学放射線学会第145回中部地方会 

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    Event date: 2009.2

    Language:Japanese  

    Country:Japan  

  636. 腕頭、鎖骨下動脈出血に対してカバードステント留置が奏功した2例

    鈴木耕次郎、松島正哉、駒田智宏、森 芳峰、太田豊裕、長縄慎二

    日本IVR学会第26回中部地方会 

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    Event date: 2009.2

    Language:Japanese  

    Country:Japan  

  637. 維持透析患者におけるヘパリン投与に関する検討

    館 靖、小島美保、改井 修、丸山邦弘、駒田智大、松島正哉、森芳峰、鈴木耕次郎、太田豊裕、長縄慎二

    日本IVR学会第26回中部地方会 

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    Event date: 2009.2

    Language:Japanese  

    Country:Japan  

  638. 甲状腺癌の肝転移に131I内用療法が著効した1例

    平野真希、岩野信吾、長縄慎二、加藤克彦、長坂徹郎

    日本核医学会第68回中部地方会 

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    Event date: 2009.2

    Language:Japanese  

    Country:Japan  

  639. 膵内副脾に襄胞性腫瘍を合併した2例

    河合雄一、森 芳峰、鈴木耕次郎、長縄慎二、伊藤茂樹

    第65回東海総合画像医学研究会 

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    Event date: 2009.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  640. 腸間膜デスモイド腫瘍の1例

    古池 亘、石垣聡子、長縄慎二

    第78回名古屋レントゲンカンファランス 

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    Event date: 2008.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  641. Visualizaition of Endolymphatic Hydrops in the Patients with Meniere's Disease by MR Imaging after Intratympanic Administration of Gd-DTPA:Its Methods, Anatomy, Findings, and Clinical Application. International conference

    RSNA(Radiology Society of North America)2008 

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    Event date: 2008.11

    Language:English  

  642. Cutting edge of inner ear MR imaging;current status and future direction.

    2008 Nagoya Symposium on Endolymphatic and Perilymphatic Imaging for Treatments of Inner Ear Diseases 

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    Event date: 2008.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  643. 3D-CTによる肺容積測定:肺癌術前の肺機能検査との相関

    岩野信吾、長縄慎二、岡阪敏樹

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    Event date: 2008.11

    Language:Japanese  

  644. コンピュータ支援診断(CAD)システムによる肺癌の容積測定

    岩野信吾、長縄慎二

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    Event date: 2008.11

    Language:Japanese  

  645. Multislice CTで精査したMirizz症候群の2例

    森 芳峰、鈴木耕次郎、太田豊裕、長縄慎二、伊藤茂樹

    第44回日本医学放射線学会秋季臨床大会 

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    Event date: 2008.10

    Language:Japanese  

    Country:Japan  

  646. 十二指腸水平脚の通過障害病変の検討:揮頭部前アーケードの動脈破綻が原因か

    伊藤茂樹、森 芳峰、鈴木耕次郎、太田豊裕、長縄慎二

    第44回日本医学放射線学会秋季臨床大会 

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    Event date: 2008.10

    Language:Japanese  

    Country:Japan  

  647. 肺門部炎症性偽腫瘍(炎症性筋線維芽細胞腫瘍)の1例

    古池亘、岩野信吾、長縄慎二、宇佐美範恭、横井香平、長坂徹郎

    第22回胸部放射線研究会 

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    Event date: 2008.10

    Language:Japanese  

    Country:Japan  

  648. Visualization of neuromelanin in the substantia nigra and locus ceruleus by 1.5-Tesla magnetic resonance imaging using a 3D-gradient echo sequence with an off-resonance magnetization transfer contrast pulse International conference

    AOCR2008-Asian Oceanian Congress of Radiology 

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    Event date: 2008.10

    Language:English  

  649. 肺門部炎症性偽腫瘍(炎症性筋線維芽細胞腫瘍)の1例

    古池亘、岩野信吾、長縄慎二、宇佐美範恭、横井香平、長坂徹郎

    第22回胸部放射線研究会 

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    Event date: 2008.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福島   Country:Japan  

  650. 乳房温存手術・術中放射線照射の安全性と有効性に関する第1・2相試験

    伊藤善之、青山裕一、石原俊一、平澤直樹、久保田誠司、伊藤淳二、長縄慎二

    日本放射線腫瘍学会第21回学術大会 

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    Event date: 2008.10

    Language:Japanese  

    Country:Japan  

  651. 放射線治療を施行した転移性脳腫瘍の予後因子

    石原俊一、伊藤淳二、久保田誠司、平澤直樹、伊藤善之、長縄慎二、池田充

    日本放射線腫瘍学会第21回学術大会 

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    Event date: 2008.10

    Language:Japanese  

    Country:Japan  

  652. 名古屋大皮膚科で施行した悪性黒色腫患者に対するセンチネルリンパ節生検の検証

    澤田昌樹、柴田真一、安江敬、榊原章浩、河野通浩、横田憲二、松本高明、富田靖、加藤克彦、長坂徹郎

    第59回日本皮膚科学会中部支部学術大会 

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    Event date: 2008.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  653. F-18 FDG PET/CT in pancreatic tumors: Is the differential diagnosis between pancreatic cancer and mass-forming pancreatitis possible? International conference

    EANM'08(Annual congress of the European Association of Nuclear Medicine) 

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    Event date: 2008.10

    Language:English  

  654. 分化型甲状腺癌の残存病巣検出におけるI-123全身シンチの診断能 International conference

    岩野信吾、加藤克彦、二橋尚志、長縄慎二

    第48回日本核医学会学術総会 

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    Event date: 2008.10

    Language:Japanese  

  655. 膵腫瘍のF-18 FDG PET/CT:膵癌と膵炎の鑑別は可能か International conference

    加藤克彦、二橋尚志、伊藤信嗣、阿部真治、西野正成、岩野信吾、伊藤茂樹、池田充、長縄慎二

    第48回日本核医学会学術総会 

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    Event date: 2008.10

    Language:Japanese  

  656. 乳腺領域における3TMRIの現状と展望

    佐竹弘子、西尾明子、石垣聡子、川村麻里子、島本佳寿広、川井恒、長縄慎二、小田高司、今井常夫

    第16回乳癌学会学術総会 

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    Event date: 2008.9

    Language:Japanese  

    Country:Japan  

  657. MRIで発見された豊胸術後乳癌の1例

    石垣聡子、西尾明子、佐竹弘子、青木桃子、小田高志、長縄慎二

    第16回乳癌学会学術総会 

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    Event date: 2008.9

    Language:Japanese  

    Country:Japan  

  658. 乳腺RVS(Real-time Virtual Sonography):3T MRIとUSの対比

    西尾明子、佐竹弘子、石垣聡子、川村麻里子、長縄慎二、島本佳寿広、小田高司、今井常夫

    第16回乳癌学会学術総会 

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    Event date: 2008.9

    Language:Japanese  

    Country:Japan  

  659. Stent-graft treatment for ruptured superior mesenteric artery pseudoaneurysm after pancreaticoduodenectomy International conference

    CIRSE 2008 

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    Event date: 2008.9

    Language:English  

  660. 鼓室内Gd-DTPA-BMA注入による蝸牛軸透過性の評価

    長縄慎二、川井恒、深津博、中島務

    第36回日本磁気共鳴医学会大会 

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    Event date: 2008.9

    Language:Japanese  

    Country:Japan  

  661. 3T-MRIにおける32ch phased array head coilの初期使用経験-12ch head coilとの比較-

    川井恒、長縄慎二、桜井康雄、二橋尚志、丸山克也

    第36回日本磁気共鳴医学会大会 

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    Event date: 2008.9

    Language:Japanese  

    Country:Japan  

  662. 前庭神経鞘腫における内耳蝸牛3D-FLAIR信号変化の検討

    山崎雅弘、川井恒、二橋尚志、深津博、長縄慎二

    第36回日本磁気共鳴医学会大会 

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    Event date: 2008.9

    Language:Japanese  

    Country:Japan  

  663. Susceptibility weighted imaging (SWI)における方向依存性

    桜井康雄、長縄慎二、石橋一郎、榊原勝治、河村美奈子、川井恒、米田和夫

    第36回日本磁気共鳴医学会大会 

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    Event date: 2008.9

    Language:Japanese  

    Country:Japan  

  664. 直腸粘膜脱症候群の1例

    平野真希、石垣聡子、佐竹弘子、長縄慎二

    第77回名古屋レントゲンカンファランス 

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    Event date: 2008.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  665. 膵の腺扁平上皮癌のCT所見の検討

    櫻井悠介、森芳峰、鈴木耕次郎、太田豊裕、長縄慎二、伊藤茂樹

    第64回東海総合画像医学研究プログラム 

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    Event date: 2008.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  666. FDG-PETで陽性所見を示した肺の炎症性偽腫瘍2例

    古池亘、岩野信吾、長縄慎二、宇佐美範恭、横井香平、長坂徹郎、高田章

    日本医学放射線学会第144回中部地方会 

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    Event date: 2008.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  667. 放射線治療を施行した転移性脳腫瘍の予後因子

    石原俊一、伊藤淳二、久保田誠司、平澤直樹、伊藤善之、長縄慎二、池田充

    日本医学放射線学会第144回中部地方会 

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    Event date: 2008.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  668. F-18 FDG-PET/CTでびまん性集積亢進が見られた多発性骨髄腫の1例

    安藤嘉朗、加藤克彦、二橋尚志、古池亘、岩野信吾、太田尚寿、河合雄一、平野真希、櫻井悠介、駒田智大、長縄慎二

    日本核医学会第67回中部地方会 

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    Event date: 2008.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  669. 肝細胞癌左三区域切除後の右肝静脈狭窄に対してstent留置が有効であった1例

    松島正哉、鈴木耕次郎、駒田智大、森芳峰、太田豊裕、長縄慎二、杉本博行

    日本IVR学会第25回中部地方会 

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    Event date: 2008.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  670. 分化型甲状腺癌お残存病巣におけるI-123シンチグラフィとI-131シンチグラフィの比較

    岩野信吾、二橋尚志、長縄慎二、加藤克彦

    日本核医学会第67回中部地方会 

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    Event date: 2008.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  671. 当院における鎖骨下静脈経由中心静脈カテーテル留置の検討(第2報)超音波ガイド下穿刺

    太田豊裕、鈴木耕次郎、森芳峰、駒田智大、松島正哉、長縄慎二、伊藤茂樹、高田章、館靖

    日本IVR学会第25回中部地方会 

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    Event date: 2008.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  672. 画像上位置が移動した膵嚢胞性腫瘍の1例

    伊藤真弥、伊藤茂樹、佐竹弘子、駒田智大、鈴木耕次郎、長縄慎二、江崎智希

    第22回腹部放射線研究会 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば   Country:Japan  

  673. 後腹膜由来の巨大Hibernomaの1例

    久保田誠司、伊藤茂樹、館靖、深津博、長縄慎二、西尾秀樹、榊原綾子 

    第22回腹部放射線研究会 

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    Event date: 2008.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば   Country:Japan  

  674. Correlation between findings of rCBF and &sup1;H-MRS in posterior cingulate gyrus for the patients with memory impariment. International conference

    HBM2008(14th Annual Meeting of the Organization for Human Brain Mapping) 

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    Event date: 2008.6

    Language:English  

  675. Evaluation of SPECT for sentinel lymph nodes of breast carcinoma fused with 3-dimensional CT International conference

    Society of Nuclear Medicine 55nd Annual Meeting 

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    Event date: 2008.6

    Language:English  

  676. MRT of Menieres's disease by intertympanic injection of Gd-DTPR at 3 Tesla. International conference

    Naganaw S

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    Event date: 2008.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Germany  

  677. Evaluation and Comparison of 11C-Choline and 18F-FDG Uptake and Calcification in Aortic and Common Carotid Arterial Walls with Combined PET/CT. International conference

    Kato K, Schober O, Ikeda M, Schäfers M, Ishigaki T, Naganawa S, Stegger L

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    Event date: 2008.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Germany  

  678. Endovascular therapy of peripancreatic artery aneurysm and bleeding. International conference

    Suzuki K, Mori Y, Komada T, Matsushima M, Ota T, Naganawa S

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    Event date: 2008.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Germany  

  679. 日独放射線医学交流計画第14回ワークショップ International conference

    3Tでの鼓室内Gd注入によるメニエール病のMR診断 

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    Event date: 2008.5

    Language:English  

  680. 肝移植後の肝内動脈瘤に対し、coil塞栓術後にstent-graft留置を施行した1例

    森 芳峰、鈴木耕次郎、駒田智大、松島正哉、太田豊裕、長縄慎二、亀井秀弥、中村太郎

    第26回日本Metallic Stents & Grafts研究会 

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    Event date: 2008.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  681. 乳房温存術の適応となった非触知石灰化乳癌の画像診断

    佐竹弘子、西尾明子、石垣聡子、川村麻里子、長縄慎二、島本佳寿広、小田高司、今井常夫、長坂徹郎

    第67回日本医学放射線学会総会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  682. 早期声門癌に対する根治的放射線治療の遡及的検討

    平澤直樹、伊藤善之、石原俊一、久保田誠司、岡田徹、伊藤淳二、長縄慎二

    第67回日本医学放射線学会総会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  683. 人工知能を用いた新しい非可逆画像圧縮法(AIC法)の開発と評価

    深津博、長縄慎二、湯村眞一郎

    第67回日本医学放射線学会総会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  684. 転移性膵腫瘍のDynamic CT所見の検討

    鈴木耕次郎、伊藤茂樹、岩野信吾、深津博、長縄慎二

    第67回日本医学放射線学会総会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  685. 膵AVMの臨床所見と画像所見の検討

    小川 浩、伊藤茂樹、鈴木耕次郎、太田豊裕、長縄慎二

    第67回日本医学放射線学会総会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  686. 胆道の炎症性腫瘤の臨床所見とCT所見の検討

    伊藤茂樹、鈴木耕次郎、長坂徹郎、太田豊裕、長縄慎二

    第67回日本医学放射線学会総会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  687. MRIを用いた乳腺RVSの臨床使用試験

    西尾明子、佐竹弘子、石垣聡子、川村麻里子、長縄慎二、島本佳寿広、小田高司、今井常夫、荒井修、三竹毅

    第67回日本医学放射線学会総会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  688. 3D-real IRと鼓室内のGd注入による単一画像での内リンパ水腫描出

    長縄慎二、川井恒、深津博

    第67回日本医学放射線学会総会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  689. 肺癌のサイズ計測におけるコンピューター支援診断:2D・3D半自動サイズ計測CAD比較

    岩野信吾、岡田徹、戸谷麗子、古池亘、伊藤真弥、石垣武男、長縄慎二、南部敏和、大沢哲、李元中

    第67回日本医学放射線学会総会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  690. 頭頸部癌に対するS-1併用化学放射線療法の臨床第1相試験

    伊藤善之、平澤直樹、岡田徹、石原俊一、久保田誠司、伊藤淳二、長縄慎二

    第67回日本医学放射線学会総会 

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    Event date: 2008.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  691. 認知症患者における後部帯状回の機能異常に関する脳血流シンチとMRスペクトロスコピーの相関関係に関して 

    二橋尚志、早坂和正、長縄慎二、新畑 豊、岩井克成、武田明敬、山岡朗子、小長谷耀子、鷲見幸彦、吉山顕次、服部英幸、佐竹昭介、三浦久幸、遠藤英俊、八谷 博 

    第20回臨床MR脳機能研究会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  692. F-18 FDG-PET of the thyroid glands:Comparison with ultrasound findings. International conference

    ECR2008 

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    Event date: 2008.3

    Language:English  

  693. Soft-copy reading of brain CT:Comparative performance study between high-grade and low-grade LCD in the electronic medical charts. International conference

    ECR2008 

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    Event date: 2008.3

    Language:English  

  694. Diagnostic value of SPIO-mediated breath-hold black blood fluid attenated inversion recovery (CBH-BB-FLAIR) imaging in patients with hepatocellar carcinomas. International conference

    ECR2008 

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    Event date: 2008.3

    Language:English  

  695. Separate visualization of endolymphatic space, perilymphatic space and bone by a single pulse sequence: Acquisition of 3D-inversion recovery sequence utilizing real reconstruction after intratympanic Gd-DTPA administration at 3 Tesla. International conference

    ECR2008 

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    Event date: 2008.3

    Language:English  

  696. Intraductal papillry mucious neoplasm of yhe pancreas: Assessment of the grade of dysplasia using multislice CT. International conference

    ECR2008 

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    Event date: 2008.3

    Language:English  

  697. 内外リンパ腔を視る

    長縄慎二

    厚生労働科学研究・研究成果等普及啓発事業による成果発表会  耳から来る’’めまい’’ー内リンパ水腫と難聴・耳鳴・めまいー 

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    Event date: 2008.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  698. 膵腫瘍の&sup1;⁸F-FDG PET/CT:膵癌と膵炎の鑑別は可能か

    加藤克彦、阿部真治、中野智、西野正成、二橋尚志、岩野信吾、山崎雅弘、松尾啓司、長縄慎二、伊藤信嗣、平澤直樹、伊藤茂樹

    日本核医学会 第66回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

    Country:Japan  

  699. 末梢肺病変に対する仮想気管支鏡(Virtual Bronchoscopy)ナビゲーション下の経気管支生検

    岩野信吾、岡田徹、長縄慎二、今泉和良、長谷川好規

    第13回三次元CT・MRI研究会 

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    Event date: 2008.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福島   Country:Japan  

  700. 3Tesla MRIでみえるようになったもの

    長縄慎二

    第22回山形県放射線科医の会 

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    Event date: 2008.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山形   Country:Japan  

  701. RVSにて乳房内リンパ節と診断できたMR incidentally detected lesionの1例

    石垣聡子、佐竹弘子、西尾明子、長縄慎二、小田高司

    日本医学放射線学会 第143回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

    Country:Japan  

  702. 子宮頸癌化学放射線療法中に高アンモニア血症を呈した1例

    岡田徹、戸谷麗子、伊藤淳二、久保田誠司、平澤直樹、川井恒、石原俊一、伊藤善之、長縄慎二、河田健司、安藤雄一

    日本医学放射線学会 第143回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

    Country:Japan  

  703. 乳房温存術後の術中照射による短期照射法第1報 臨床実験の概要と初期報告

    伊藤善之、石原俊一、岡田徹、平澤直樹、久保田誠司、伊藤淳二、長縄慎二、今井常夫、澤木正孝

    日本医学放射線学会 第143回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

    Country:Japan  

  704. 頭頸部癌に対するTS-1併用化学放射線療法の臨床第Ⅰ相試験

    伊藤善之、平澤直樹、岡田徹、石原俊一、久保田誠司、伊藤淳二、長縄慎二、加藤賢史、橋本保志、中島務

    日本医学放射線学会 第143回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

    Country:Japan  

  705. 早期声門癌に対する根治的放射線治療の遡及的検討

    平澤直樹、石原俊一、岡田徹、久保田誠司、伊藤淳二、伊藤善之、長縄慎二、堀川よしみ

    日本医学放射線学会 第143回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

  706. 膵AVMの臨床所見と画像所見の検討

    小川浩、鈴木耕次郎、太田豊裕、長縄慎二、伊藤茂樹

    日本医学放射線学会 第143回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

  707. 子宮頸癌治療中に意識障害となり、MRIにて脳幹背側から視床に異常信号を認めた1例

    戸谷麗子、岡田徹、川井恒、石原俊一、伊藤善之、長縄慎二

    日本医学放射線学会 第143回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

    Country:Japan  

  708. 肺癌の造影ダイナミックCT:腺癌と扁平上皮癌の違い

    岩野信吾、岡田徹、長縄慎二、下山芳江、神岡祐子

    日本医学放射線学会 第143回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

    Country:Japan  

  709. 肺結節性病変に対する仮想気管支鏡ナビゲーション下生検の診断能

    岩野信吾、岡田徹、長縄慎二、今泉和良、長谷川好規

    日本医学放射線学会 第143回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

  710. 肺癌の2D・3D半自動サイズ計測CADの開発

    岩野信吾、岡田徹、戸谷麗子、伊藤真弥、山崎雅弘、石垣武男、長縄慎二、古池亘、南部敏和、大沢哲、李元中

    日本医学放射線学会 第143回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

    Country:Japan  

  711. 3D-CTによる肺容積の測定:肺癌術前の肺機能検査と相関について

    岩野信吾、岡田徹、長縄慎二

    日本医学放射線学会 第143回中部地方会 

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    Event date: 2008.2

    Language:Japanese  

  712. 回腸に広範囲に及ぶ狭窄を呈した腸結核の1例

    名古屋レントゲンカンファランス 

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    Event date: 2007.12

    Language:Japanese  

    Country:Japan  

  713. 臨床講演~Aquilion ONE の魅力とリンショウデータ紹介~

    長縄慎二

    エリアデテクタCTセミナー 

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    Event date: 2007.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  714. 放射線治療を施行した骨転移患者の予後

    石原俊一、久保田誠司、平澤直樹、岡田 徹、伊藤善之、長縄慎二、奥田隆仁

    日本放射線腫瘍学会第20回学術大会 

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    Event date: 2007.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  715. 画像診断の最前線ーいかに病態に迫るかー 「中耳・内耳疾患とMRI」

    長縄慎二

    第21回日本耳鼻咽喉科学会専門医講演会 

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    Event date: 2007.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  716. Venography of Multiple Sclerosis Using Susceptibity-weighted Imaging at 3-Tesla MRI.

    RSNA 2007 

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    Event date: 2007.11

    Language:English  

  717. 名大病院放射線科って何をしているの?

    長縄慎二

    昭和区医師会学会学術講演会 

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    Event date: 2007.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  718. 難聴症例における画像診断

    長縄慎二

    第52回日本聴覚医学会学術講演会ランチョンセミナー 

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    Event date: 2007.10

    Language:Japanese  

  719. Diagnostic Oncology: Planar Scintigraphy and SPECT - Lymphoscintigraphy, lymphatic mapping and sentinel node.

    EANM'07 

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    Event date: 2007.10

    Language:English  

  720. Combination of F-18 FDG PET, T1-201 Scintigraphy and I-131 Scintigraphy Improves the Rate of Detecting Dfferentiated Thyroid Cancer Undergoing I-131 Therapy after Total Thyroidectomy.

    EANM'07 

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    Event date: 2007.10

    Language:English  

  721. MRIを用いたRVSと乳管造影CTが有用であった非触知乳癌(乳頭血性分泌)の1例

    西尾明子,佐竹弘子,石垣聡子,川村麻里子,長縄慎二,小田高司.角田伸行

    第4回日本乳癌学会中部地方会 

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    Event date: 2007.9

    Language:Japanese  

    Country:Japan  

  722. 胸腔内結石の1例

    伊藤真弥、岩野信吾、長縄慎二

    名古屋レントゲンカンファランス 

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    Event date: 2007.9

    Language:Japanese  

    Country:Japan  

  723. 脳腫瘍患者の術前マッピング-fMRIを用いた検討

    二橋尚志, 竹林成典, 早坂和正, 文堂昌彦, 藤井正純, 若林俊彦, 吉田純, 藤沢洋幸, 清水ひとみ, 長縄慎二

    第30回日本神経科学大会 

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    Event date: 2007.9

    Language:Japanese  

    Country:Japan  

  724. CONTRAST ENHANCED MR IMAGING OF METASTATIC BRAIN TUMOR AT 3 TESLA.

    32nd ESNR ANNUAL MEETING & 16th Advanced Course 

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    Event date: 2007.9

    Language:English  

  725. Pancreaticodenal artery aneurysms associated with celiac axis stenosis:treatment with transcatheter arterial embolization.

    Cardiovascular and Interventional Radiological Society of Europe 2007 

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    Event date: 2007.9

    Language:English  

  726. 3T-MRI における頭部造影 2D-T1 強調画像の検討:BLADE併用T1-FLAIRとconventional SE-T1強調像との比較

    川井恒、長縄慎二、駒田智大、二橋尚志、深津博、櫻井康雄、河村美奈子

    第35回日本磁気共鳴医学会 

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    Event date: 2007.9

    Language:Japanese  

    Country:Japan  

  727. 鼓室内Gd注入による内耳の外リンパ腔画像と内リンパ腔画像の取得

    長縄慎二、河村美奈子、櫻井康雄、川井恒、深津博

    第35回日本磁気共鳴医学会 

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    Event date: 2007.9

    Language:Japanese  

    Country:Japan  

  728. 鼓室内Gd注入後の単一画像による内外リンパ腔分離描出;3D-real IRの有用性

    長縄慎二、河村美奈子、櫻井康雄、川井恒、深津博

    第35回日本磁気共鳴医学会 

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    Event date: 2007.9

    Language:Japanese  

    Country:Japan  

  729. 鼓室内Gd注入後の内外リンパ腔分離描出;3D-real IR撮像条件最適化の基礎的検討

    河村美奈子、櫻井康雄、石橋一都、榊原勝浩、駒田友美、安藤康生、田中宏明、米田和夫、長縄慎二

    第35回日本磁気共鳴医学会 

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    Event date: 2007.9

    Language:Japanese  

    Country:Japan  

  730. マルチスライスCTにて診断し得た回腸重複腸管の一例

    中根俊樹、太田豊裕、長縄慎二、伊藤茂樹、藤原道隆、大宮直木

    日本医学放射線学会 第142回中部地方会 

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    Event date: 2007.7

    Language:Japanese  

  731. 18F-FDG-PETで集積亢進が見られた両側副腎結核

    加藤克彦、岩野信吾、松島正哉、駒田智大、小川 浩、久保田誠司、川井 恒、阿部真治、中野 智、西野正成、長縄慎二、西尾正美、池田 充

    日本医学放射線学会 第142回中部地方会 

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    Event date: 2007.7

    Language:Japanese  

    Country:Japan  

  732. 検診で発見された腸重積を伴うPeutz-Jeghers”Syndromeの一例

    川瀬世津子、伊藤信嗣、牧野直樹、杉浦正彦、篠田昌孝、高桑康成、伊藤真弥、長縄慎二

    日本医学放射線学会 第142回中部地方会 

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    Event date: 2007.7

    Language:Japanese  

  733. 放射線治療を施行した骨転移患者の予後

    石原俊一、久保田誠司、平澤直樹、岡田徹、伊藤善之、長縄慎二、奥田隆仁

    日本医学放射線学会 第142回中部地方会 

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    Event date: 2007.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  734. 肝巨大未分化肉腫の1例

    駒田智大、鈴木耕次郎、長縄慎二、伊藤茂樹、西尾秀樹

    日本医学放射線学会 第142回中部地方会 

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    Event date: 2007.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  735. 移動型術中照射装置の使用経験

    伊藤善之、青山裕一、石原俊一、岡田徹、平澤直樹、久保田誠司、長縄慎二、堀川よしみ

    日本医学放射線学会 第142回中部地方会 

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    Event date: 2007.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  736. 当院におけるDSAロードマップによる鎖骨下静脈経由中心静脈カテーテル留置の検討

    太田豊裕、鈴木耕次郎、森 芳峰、駒田智大、松島正哉、長縄慎二、伊藤茂樹、高田 章、館  靖

    日本IVR学会 第23回中部地方会 

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    Event date: 2007.6

    Language:Japanese  

    Country:Japan  

  737. coil塞栓術を施行した肝動脈—門脈瘻の1例

    森 芳峰、駒田智大、松島正哉、鈴木耕次郎、太田豊裕、長縄慎二、伊藤茂樹

    日本IVR学会第23回中部地方会 

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    Event date: 2007.6

    Language:Japanese  

  738. 3Teslaでの3D Imagingの進歩

    第16回造影剤 と放射線シンポジウム(CMRS) 

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    Event date: 2007.6

    Language:Japanese  

  739. 内耳MRI:正常解剖から最近の進歩まで

    愛知県放射線科医会総会 

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    Event date: 2007.6

    Language:Japanese  

  740. Comparison of 123I-IMP SPECT and 18F-FDG PET in detection of primary lesions and metastases of lesions and metastases of cutaneous malignant melanoma.

    Society of Nuclear Medicine 54nd Annual Meeting 

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    Event date: 2007.6

    Language:English  

  741. The various pattern of the brain activation in the primary somatosensory cortex of the patients with brain tumor-An fMRI and FDG-PET study.

    13th Annual Meeting of the Organization for Human Brain Mapping 

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    Event date: 2007.6

    Language:English  

  742. 後腹膜由来の巨大Hibernomaの1例

    第21回 腹部放射線研究会 

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    Event date: 2007.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  743. 甲状腺腫術後26年目に発症した甲状線濾胞癌膵転移の一例

    第21回 腹部放射線研究会 

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    Event date: 2007.6

    Language:Japanese  

    Country:Japan  

  744. 輪状膵に膵胆管合流異常を合併した1例

    第21回 腹部放射線研究会 

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    Event date: 2007.6

    Language:Japanese  

    Country:Japan  

  745. 「画像診断とは?放射線科とは?」

    長縄慎二

    第1回基礎からの画像診断研修会 

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    Event date: 2007.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  746. Contrast enhanced MR imaging of the brain using T1-FLAIR with BLADE compared with conventional spin echo sequence.

    ISMRM/15 

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    Event date: 2007.5

    Language:English  

  747. 胆管・膵悪性腫瘍術後の遅発性出血に対するIVR

    駒田智大、鈴木耕次郎、松島正哉、森 芳峰、太田豊裕、長縄慎二、高田章

    第36回 日本IVR学会総会 

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    Event date: 2007.5

    Language:Japanese  

    Country:Japan  

  748. 非触知石灰化乳癌におけるRVSの有用性について

    佐竹弘子、澤木明子、石垣聡子、長縄慎二、島本佳寿広、福原理恵子、三竹 毅、荒井 修、長坂徹朗、小田高司、今井常夫

    JSUM 2007 日本超音波医学会第80回学術集会 

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    Event date: 2007.5

    Language:Japanese  

    Country:Japan  

  749. 脳神経臨床診療に役立つ最新MRI

    長縄慎二

    第9回放射線研究セミナー 

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    Event date: 2007.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  750. Intraductal papillary mucinous neoplasm(IPMN)のマルチスライスCT所見の検討

    小川浩、鈴木耕次郎、長縄慎二、伊藤茂樹

    第66回日本医学放射線学会学術集会 

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    Event date: 2007.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  751. 画像診断 ―精度は高く、侵襲は低く―  3テスラMRIによる3次元画像の進歩

    長縄慎二

    第27回 日本医学会総会 2007 大阪 

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    Event date: 2007.4

    Language:Japanese  

    Country:Japan  

  752. Computer-aided diagnosis of lung canaer:Definition and detection of ground-glass opasity on high-resolution CT.

    ECR2007 

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    Event date: 2007.3

    Language:English  

  753. Intraductal papillary mucinous neoplasm(IPMN)のマルチスライスCT所見の検討

    小川浩, 伊藤茂樹, 鈴木耕次郎, 長縄慎二

    日本医学放射線学会第141回中部地方会 

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    Event date: 2007.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  754. 3−tesla MRIによるSusceptibility-Weighted Imaging(SWI)を用いた多発性硬化症の脱髄巣を走行する静脈描出頻度の検討

    久保田誠司、川井恒、深津博、長縄慎二

    日本医学放射線学会第141回中部地方会 

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    Event date: 2007.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  755. 乳癌センチネルリンパ節シンチの評価:3DCTとのfusion

    加藤克彦、佐竹弘子、岩野信吾,澤木明子、阿部真治、中野智、西野正成、長縄慎二、池田充、小林英敏、田所匡典

    日本核医学会第64回中部地方会 

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    Event date: 2007.2

    Language:Japanese  

  756. 喀血で発症した両側性気管支動脈蔓状血管腫に対して気管支動脈塞栓術が奏功した1例

    松島正哉、鈴木耕次郎、駒田智大、森芳峰、太田豊裕、長縄慎二、肥田野暁、小川雅弘

    日本IVR学会第22回中部地方会 

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    Event date: 2007.2

    Language:Japanese  

  757. 正中弓状靭帯圧迫症候群に合併した背側膵動脈瘤破裂に対してTAEを施行した1例

    伊藤信嗣、川瀬世津子、牧野直樹、鈴木耕次郎、長縄慎二

    日本IVR学会第22回中部地方会 

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    Event date: 2007.2

    Language:Japanese  

  758. 脳外科臨床に役立つ最近のMRI撮像法

    長縄慎二

    第30回日本脳神経CI学会総会 

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    Event date: 2007.2

    Language:Japanese  

    Country:Japan  

  759. 脈絡膜悪性黒色腫に対する炭素イオン線治療

    平澤直樹、伊藤善之、石原俊一、岡田徹、長縄慎二、辻比呂志、加藤弘之、野宮琢麿、鎌田正、溝江純悦、辻井博彦

    日本医学放射線学会第141回中部地方会 

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    Event date: 2007.2

    Language:Japanese  

  760. 肺癌の経過観察における肺門・肝臓同時評価のためのルーチン造影法

    神岡祐子、岩野信吾、佐竹弘子、岡田徹、長縄慎二 、伊藤茂樹

    日本医学放射線学会第141回中部地方会 

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    Event date: 2007.2

    Language:Japanese  

    Country:Japan  

  761. 肺癌のコンピュータ支援診断:類似症例検索ソフトの開発

    岩野信吾、岡田徹、神岡祐子、石垣武男、長縄慎二

    日本医学放射線学会第141回中部地方会 

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    Event date: 2007.2

    Language:Japanese  

    Country:Japan  

  762. 放射線科医ののぞむ読影環境

    長縄慎二

    名古屋大学—富士フィルム共同研究ミーティング 

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    Event date: 2007.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:小田原   Country:Japan  

  763. 乳腺の神経内分泌腫瘍の1例

    小川 浩、澤木明子、佐竹弘子、長縄慎二、今井常夫、澤木正孝、山本英子、宮田友子

    第61回東海総合画像研究会  

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    Event date: 2007.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  764. 鼓室内Gd注入による迷路内リンパ水腫の観察

    長縄慎二, 深津博, 川井恒

    日本医学放射線学会 

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    Event date: 2007

    Language:Japanese  

    Country:Japan  

  765. 人工知能Neural Networkを用いたLossless画像圧縮方法(JIS圧縮法)の開発と評価

    深津博, 長縄慎二, 湯村眞一郎

    日本医学放射線学会 

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    Event date: 2007

    Language:Japanese  

    Country:Japan  

  766. 拡散テンソル画像を用いた多系統萎縮症とパーキンソン病の錐体路評価

    伊藤瑞規, 熱田直樹, 川合圭成, 渡邉宏久, 祖父江元, 長縄慎二, 深津博, 石垣武男

    臨床神経学会 

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    Event date: 2007

    Language:Japanese  

  767. 側頭骨 内耳・内耳道

    長縄慎二

    日本医学放射線学会 

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    Event date: 2007

    Language:Japanese  

    Country:Japan  

  768. 肺癌の類似CT画像検索CADの初期的検討

    岩野信吾, 岡田徹, 神岡祐子, 石垣武男, 長縄慎二

    日本医学放射線学会 

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    Event date: 2007

    Language:Japanese  

    Country:Japan  

  769. 3T MRIによる磁化率強調画像(SWI)を用いた多発性硬化症の脱髄巣を走行する静脈描出頻度の検討

    久保田誠司, 川井恒, 深津博, 長縄慎二

    日本医学放射線学会 

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    Event date: 2007

    Language:Japanese  

    Country:Japan  

  770. 遠隔画像診断クリニックにおける業務分析と課題

    村瀬詠子, 深津恵理子, 石垣武男, 古賀佑彦, 加藤克彦, 深津博, 長縄慎二, 島本佳寿広

    日本医学放射線学会 

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    Event date: 2007

    Language:Japanese  

    Country:Japan  

  771. 腹腔動脈狭窄に因る膵仮性動脈瘤に対するTAE

    鈴木耕次郎, 館靖, 森芳峰, 太田豊裕, 長縄慎二, 丸山邦弘, 伊藤信嗣, 白石里支

    日本医学放射線学会 

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    Event date: 2007

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  772. ネットワーク上の情報のorganic recirculation 比較CT interpretationにおける放射線科医に及ぼすその臨床的影響(Organic Recirculation of Information On Network: Its Clinical Impact for Radiologists in Comparative CT Interpretation)

    深津博, 長縄慎二, 長田雅和, 増沢高

    日本医学放射線学会 

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    Event date: 2007

    Language:Japanese  

  773. 腹側膵領域の限局性炎症の画像所見

    伊藤茂樹, 鈴木耕次郎, 川井恒, 長縄慎二

    日本医学放射線学会 

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    Event date: 2007

    Language:Japanese  

    Country:Japan  

  774. 後腹膜に進展した肋骨原発軟骨肉腫の1 例

    松島正哉、 鈴木耕二郎、長縄慎二

    第70回名古屋レントゲンカンファランス 

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    Event date: 2006.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  775. &sup1;&sup2;&sup3;I-IMP SPECT of primary lesions and metastases of cutaneous malignant melanoma: comparison with &sup1;⁸F-FDG PET International conference

    Radiological Society of North America, The 90th Scientific Assembly and Annual Meeting 

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    Event date: 2006.11

    Language:English  

  776. 臨床3T MR;各種3D-SPACEの有用性について

    長縄慎二

    第34回日本磁気共鳴医学会大会ランチョンセミナー 

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    Event date: 2006.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:つくば   Country:Japan  

  777. 3T MRの臨床的有用性;各種3D-SPACEについて

    長縄慎二

    MRアーベント鹿児島 

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    Event date: 2006.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島   Country:Japan  

  778. 肺出血で発症した心臓原発血管肉腫の1 例

    岩野信吾、長縄慎二

    第69回名古屋レントゲンカンファランス 

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    Event date: 2006.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  779. Comparison of 18F-FDG PET and bone scintigraphy in detection of bone metastases of thyroid cancer.

    Annual congress of the European Association of Nuclear Medicine 

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    Event date: 2006.9

    Language:English  

  780. 転移性脳腫瘍検出におけるT1強調画像3D-SPACE法の有用性;3D-MP-RAGE法、2D-SE法との比較

    駒田智大、長縄慎二、久保田誠司、小川浩、川井恒、深津博、池田充、丸山克也

    第34回日本磁気共鳴医学会大会 

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    Event date: 2006.9

    Language:Japanese  

  781. 頭蓋底外科手術に役立つ画像診断のシンポ 頭蓋底手術に役立つ最近のMRのシンポ

    長縄慎二

    第18回日本頭蓋底外科学会 

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    Event date: 2006.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  782. 核医学、PET画像診断の基本

    長縄慎二

    核医学、PET画像診断の基本 

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    Event date: 2006.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  783. 肝臓における拡散強調画像について

    長縄慎二

    第20回ART会記念講演会 

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    Event date: 2006.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  784. Advanced 3D imaging 3 Tesla.

    20th Imternational computer assisted radiology and surger 

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    Event date: 2006.6

    Language:English  

  785. Observation of contrast enhancement in cochlear fluid space of helthy subjects using 3D-FLAIR sequence at 3 Tesla.

    13th Workshop of the German-Japanese Radiological Affiliation 

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    Event date: 2006.3

    Language:English  

    Country:Japan  

  786. Breath-hold diffusion weighted image of the liver for the detection of focal lesions.

    13th Workshop of the German-Japanese Radiological Affiliation 

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    Event date: 2006.3

    Language:English  

    Country:Japan  

  787. 3種類の3D-FLAIRの有用性

    長縄慎二

    第1回3T MR研究会 

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    Event date: 2006.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  788. 非造影検査でどこまで診断に迫れるか? 高磁場MRI

    長縄慎二

    断層映像研究会 

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    Event date: 2006

    Language:Japanese  

    Country:Japan  

  789. 著明な肉芽形成が見られた腫瘤形成性膵炎の一例

    中根俊樹, 鈴木耕次郎, 長縄慎二, 伊藤茂樹, 金住直人, 下山芳江

    日本医学放射線学会 

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    Event date: 2006

    Language:Japanese  

    Country:Japan  

  790. 3Teslaにおける3D-FLAIRを用いた蝸牛リンパ液の造影効果の観察

    長縄慎二, 深津博, 石垣武男

    日本医学放射線学会 

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    Event date: 2006

    Language:Japanese  

    Country:Japan  

  791. マルチスライスCTによる無症候性の腹腔動脈狭窄の検討

    森芳峰, 鈴木耕次郎, 佐竹弘子, 太田豊裕, 長縄慎二, 伊藤茂樹

    日本医学放射線学会 

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    Event date: 2006

    Language:Japanese  

    Country:Japan  

  792. 拡散テンソル画像を用いた多系統萎縮症の錐体路評価

    伊藤瑞規, 熱田直樹, 渡邉宏久, 祖父江元, 長縄慎二, 深津博, 石垣武男

    臨床神経学会 

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    Event date: 2006

    Language:Japanese  

    Country:Japan  

  793. Diffusion-weighted imaging of the liver ; its technical optimization and clinical application. International conference

    Radiological Society of North America, The 91th Scientific Assembly and annual Meeting 

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    Event date: 2005.11

    Language:English  

  794. 腹部拡散強調画像における技術的課題と展望

    長縄慎二

    第16回放射線技師フォーラム 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  795. 非造影検査でどこまで診断に迫れるか?;高磁場

    長縄慎二

    第34回断層映像研究会 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  796. 3T 元年;上腹部、下腹部編

    長縄慎二

    第10回 MRIと造影剤のフォーラム 

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    Event date: 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  797. 腹部における拡散強調画像の技術的問題

    長縄慎二

    第33回日本磁気共鳴医学会大会 

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    Event date: 2005.9 - 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  798. 高磁場MRI;SAR対策について

    長縄慎二

    第33回日本磁気共鳴医学会大会 

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    Event date: 2005.9 - 2005.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  799. 内耳領域の画像診断

    長縄慎二

    第11回東海メニエール病研究会 

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    Event date: 2005.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  800. 多発性内分泌腺腫症(MEN)1型に合併したpeliosishepatisの1例

    山崎雅弘、鈴木耕次郎、森芳峰、長縄慎二、伊藤茂樹、竹田伸、下山芳江

    第62回東海総合画像研究会 

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    Event date: 2005.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  801. 磁石で身体を視る

    長縄慎二

    第64回日本医学放射線学会学術集会記念行事 市民公開講座 

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    Event date: 2005.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  802. 卵巣顆粒膜細胞腫の1 例

    久保田誠司、長縄慎二、深津 博、石垣武男

    第64回名古屋レントゲンカンファランス 

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    Event date: 2005.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  803. 3T MRIの臨床的特徴 とくに神経放射線領域において

    長縄慎二

    Radiology Update 

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    Event date: 2005.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  804. 3T MRIの臨床的特徴

    長縄慎二

    日本磁気共鳴医学会 安全評価委員会講演会 

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    Event date: 2005.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  805. MRIの最近の進歩と安全性:3T-MRI装置の臨床的利点について 

    長縄慎二

    日本磁気共鳴医学会 安全評価委員会講演会 

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    Event date: 2005.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  806. 3Tの全脳isotropic imaging

    長縄慎二

    第2回中部Magnetom研究会 

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    Event date: 2005.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  807. 多系統萎縮症における認知機能障害 画像との関連

    川合圭成, 伊藤瑞規, 渡邉宏久, 祖父江元, 武田章敬, 長縄慎二, 深津博, 加藤克彦, 石垣武男

    臨床神経学会 

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    Event date: 2005

    Language:Japanese  

    Country:Japan  

  808. 多発性硬化症におけるIsotropic 3D FLAIR法の有用性

    末永正機, 伊藤瑞規, 熱田直樹, 渡邉宏久, 祖父江元, 深津博, 長縄慎二

    臨床神経学会 

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    Event date: 2005

    Language:Japanese  

    Country:Japan  

  809. Isotropic 3D-MR Imaging of the Whole Brain by Variable Flip Angle Single Slab 3D-TSE Sequence from Basic Concept to Clinical Advantages International conference

    Radiological Society of North America, The 90th Scientific Assembly Meeting 

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    Event date: 2004.11

    Language:English  

  810. 高磁場MRIにおける高速イメージングの実際

    長縄慎二

    第32回日本磁気共鳴医学会大会 

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    Event date: 2004.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:滋賀   Country:Japan  

  811. Contrast-enhanced MR imaging of the small canals in temporal bone. International conference

    Naganawa S, Koshikawa T, Nakamura T, Fukatsu H, Ishigaki T, Nakashima T

    2004 Nagoya Sudden Deafness Symposium 

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    Event date: 2004.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  812. The Clinical Value of Diffusion Weighted Image for Prostate Cancer at Tesla. International conference

    Fukatsu H, Naganawa S, Ishigaki T

    ISMRM 12th Scientific Meeting & Exhibition 

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    Event date: 2004.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  813. 3T MRIの臨床的有用性とnew application

    長縄慎二

    第6回放射線研究セミナー 

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    Event date: 2004.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  814. Optimization and clinical application of diffusion-tensor MR imaging date acquisition parmeters for brain fiber tracking using parallel imaging at 3 T. International conference

    12th Workshop of the Japanese~German Radiological Affiliation 

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    Event date: 2004.4

    Language:English  

  815. The accuracy of the cancerous invasion to the gastric wall with MRI in vitro. International conference

    Sato C, Naganawa S, Kumada H, Miura T, Ishigaki T

    ECR2004 

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    Event date: 2004.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Austria  

  816. 3T MRIの基礎的、臨床的特徴

    長縄慎二

    先端画像診断講演会 

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    Event date: 2004.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  817. Optimization of Diffusion Tensor MR Imaging Date Acquisition Parameters for Brain Fiber Tracking using Parallel Imaging at 3T. International conference

    The 12th meeting of International Society of Magnetic Resonance in Medicine 

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    Event date: 2004.3

    Language:English  

  818. Contrast enhancement of the cochlear aqueduct in MR imaging: its frequency and clinical significance. International conference

    16th European Congress of Radiology 

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    Event date: 2004.3

    Language:English  

  819. Staging of gastric carcinoma byMR imaging in vitro. International conference

    16th European Congress of Radiology 

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    Event date: 2004.3

    Language:English  

  820. 3T-MRI; What do we see?

    長縄慎二

    第1回画像診断放射線治療研究会 

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    Event date: 2004.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  821. Enlarged endolymphatic sac syndrome:Relationship between MR finding and genotype of mutation in Pendred gene. International conference

    Naganawa S, Fukatsu H, Ishigaki T, Nakashima T

    RSNA2003 

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    Event date: 2003.11 - 2003.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  822. 知っておきたい最近のMRIの話題

    長縄慎二

    第3回先端量子医学研究セミナー 

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    Event date: 2003.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  823. High-Resolution T1-Weighted 3D-Real IR Imaging of the Temporal Bone Using Triple-Dose Contrast and a Dedicated Surface Phased Array Coil. International conference

    Naganawa S, Koshikawa T Fukatsu H, Aoki I, Ishigaki T

    RSNA2002 

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    Event date: 2002.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  824. 小脳橋角部領域のMR

    長縄慎二

    第15回 頭頸部放射線研究会 

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    Event date: 2002.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  825. Regional ADC Values of the Normal Brain: The Effect of Aging, Comparison between Male and Female, and Comparison between Right and Left Side. International conference

    Naganawa S, Sato K, Katagiri T, Mimura T, Ishigaki T

    USA,Hawaii 

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    Event date: 2002.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  826. Pre-surgical mapping of primary motor cortex by functional MRI at 3 T:Effects of intravenous administration of Gd-DTPA. International conference

    Naganawa S, Nihashi T, Fukatsu H,Ishigaki T

    International symposium on Oncologic MR imaging 

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    Event date: 2002.3

    Language:English   Presentation type:Oral presentation (general)  

  827. 中内耳の画像診断

    長縄慎二

    尾張耳鼻咽喉科医会研修会 

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    Event date: 2002.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  828. Contrast-enhanced MR imaging of the endolymphatic sac in patients with sudden hearing loss -withdrawn due to terorrism. International conference

    Naganawa S, Koshikawa T Fukatsu H, Ishigaki T, Nakashima T, Ichinose N

    RSNA2001 

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    Event date: 2001.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  829. MD-CTとMRI 中枢神経と頭頸部疾患 頭蓋底、側頭骨

    長縄慎二

    第30回断層映像研究会 

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    Event date: 2001.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山   Country:Japan  

  830. MS-CT vs MRI 内耳領域

    長縄慎二

    第6回MRIと造影剤のフォーラム 

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    Event date: 2001.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  831. Comparison between Magnitude Subtraction vs Complex Subtraction in Dynamic Contrast Enhanced 3D-MR Angiography: Basic Experiments and Clinical Application. International conference

    Naganawa S, Ito T, Iwayama E, Fukatsu H,Ishigaki T, Ichinose N

    International symposium on Ultra-fast MRI 

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    Event date: 2001.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  832. 聴覚 内耳のMRI

    長縄慎二

    第49回静岡県MRI研究会 

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    Event date: 2001.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  833. Fast recovery 3D-fast spin echo imaging of the inner ear at 3T. International conference

    Naganawa S, Koshikawa T, Fukatsu H, Ishigaki T, Ninomiya A, Aoki I

    ISMRM 9th Scientific Meeting & Exhibition 

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    Event date: 2001.4

    Language:English   Presentation type:Oral presentation (general)  

  834. ドイツでのfunctional MRIの現状

    長縄慎二

    第3回放射線医学研究セミナー 

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    Event date: 2001.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  835. MR cisternography of cerebellopontine angle: Comparison of 3D-FastASE and 3D-CISS sequence. International conference

    Naganawa S, Koshikawa T, Fukatsu H, Ishigaki T

    ECR2001 

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    Event date: 2001.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Austria  

  836. MR imaging of auditory pathway. International conference

    Naganawa S, Koshikawa T

    Max-planc institute of cognitive neuroscience; neurology-NMR seminar 

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    Event date: 2001.1

    Language:English   Presentation type:Oral presentation (general)  

  837. MR imaging of inner ear in Y2K. International conference

    Naganawa S, Koshikawa T

    International symposium of head and neck imaging 

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    Event date: 2000.10

    Language:English   Presentation type:Oral presentation (general)  

  838. 最近のMRIの特徴と向かうべき方向

    長縄慎二

    第3回アドバンストMRイメージングフォーラム 

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    Event date: 2000.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  839. 内耳MRIの現状

    長縄慎二

    第2回放射線医学研究セミナー  

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    Event date: 2000.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  840. Virtual Endoscopy of the Labyrinth Using a 3D-FastASE Sequence. International conference

    Naganawa S, Kawai H, Iwayama E, Ito T, Fukatsu H, Ishigaki T, Ninomiya A, Aoki I

    8th Scientific Meeting and Exhibition ISMRM 

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    Event date: 2000.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  841. High-resolution MR imaging of enlarged endolymphatic duct and sac syndrome using 3D-FastASE: Volume and signal-intensity measurement of the endolymphatic duct and sac, and area measurement of the cochlear modiolus. International conference

    Naganawa S, Koshikawa T, Iwayama E, Fukatsu H, Ishiguchi T, Ishigaki T, Nakashima T, Ichinose N

    8th Scientific Meeting and Exhibition ISMRM 

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    Event date: 2000.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  842. 内耳MRIの現状と将来

    長縄慎二

    第29回頭頸部放射線研究会関東支部 

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    Event date: 1999.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  843. MR Imaging of the labyrinth: Current capabilities and future challenges. International conference

    Naganawa S, Ito T, Iwayama E, Fukatsu H, Ishigaki T, Nakashima T, Ichinose N

    RSNA1999 

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    Event date: 1999.11 - 1999.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  844. 仮想内視鏡

    長縄慎二

    第4回MRIと造影剤のフォーラム 

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    Event date: 1999.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  845. MR imaging of the cochlear modiolus: Comparison of normal subjents and patients. International conference

    Naganawa S, Ito T, Iwayama E, Fukatsu H, Ishigaki T, Nakashima T, Ichinose N

    RSNA1998 

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    Event date: 1998.11 - 1998.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  846. 最新MRI診断

    長縄慎二

    名古屋市北区医師会学術講演会 

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    Event date: 1998.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  847. High-Resolution MR Cisternography of the Cerebellopontine Angle Using a 3D-fast Asymmetric Spin Echo Sequence in a 0.35 T Open MR Unit. International conference

    Naganawa S, Ito T, Fukatsu H, Ishigaki T, Nakashima T, Ichinose N, Segawa T

    Naganawa S, Ito T, Fukatsu H, Ishigaki T, Nakashima T, Ichinose N, Segawa T 

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    Event date: 1998.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  848. Open MRIと高速MRIの有用性--頭頚部領域を中心に

    長縄慎二

    静岡MRIセミナー 

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    Event date: 1998.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  849. High resolution MR imaging of the inner ear using 3D-FSE with a ultra-long echo train length and a dedicated QD-surface phased array coil International conference

    Naganawa S, Ito T, Fukatsu H, Ishigaki T, Nakashima T, Ichinose N, Kassai Y, Miyazaki M

    RSNA 1997 

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    Event date: 1997.11 - 1997.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  850. 最近のMRIのシンポ

    長縄慎二

    第12回三河MRI研究会 

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    Event date: 1997.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  851. High resolution MR imaging of the inner ear using 3D-FSE with a ultra-long echo train length and a dedicated QD-surface phased array coil. International conference

    Naganawa S, Ito T, Fukatsu H, Ishigaki T, Nakashima T, Ichinose N, Kassai Y, Miyazaki M

    5th Scientific Meeting and Exhibition ISMRM 

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    Event date: 1997.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Canada  

  852. 選択的卵管造影におけるデジタル透視記録画像の評価

    石口恒男、村瀬詠子、加藤加代子、長縄慎二、丸山邦弘、石垣武男 

    日本医学放射線学会第55回学術集会 

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    Event date: 1997.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  853. 3D-FastASE法とQD-surface phased array coilを用いた内耳高分解能MRIno有用性の検討 International conference

    長縄慎二、伊藤登紀子、村瀬詠子、深津 博、石垣武男、市ノ瀬伸保

    日本医学放射線学会第55回学術集会 

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    Event date: 1997.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  854. Rheumatoid arthritisによる頚椎病変のMR所件の検討

    二瓶江理子、深津 博、伊藤都紀子、岩山恵利子、長縄慎二、石垣武男

    日本医学放射線学会第121回中部地方会 

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    Event date: 1997.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  855. 3D-FASE法とQD-surface phased array coilを用いた内耳の高分解能MRIの有用性の検討

    長縄慎二、伊藤都紀子、村瀬詠子、深津 博、石垣武男、市ノ瀬伸保、葛西由守

    日本医学放射線学会第121回中部地方会 

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    Event date: 1997.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  856. Local gradient coil systemを用いた人体頭部標本の内耳の高分解能MRI----組織学的標本との対比

    伊藤都紀子、長縄慎二、村瀬詠子、深津 博、石垣武男

    日本医学放射線学会第121回中部地方会 

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    Event date: 1997.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  857. 膝窩動脈補捉症候群の1例―血管撮影・MRI・内視鏡所件を中心に―

    岩山恵理子、伊藤都紀子、加藤加代子、長縄慎二、丸山邦弘、深津 博、石口恒男、石垣武男

    第41回東海総合画像医学研究会 

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    Event date: 1997.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  858. ヨード造影剤過敏症における胸部大動脈瘤のステントグラフト治療前後の評価にMRアンギオグラフィが有用であった1例

    伊藤都紀子、加藤加代子、長縄慎二、丸山邦弘、深津 博、石口恒男、石垣武男

    第41回東海総合画像医学研究会 

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    Event date: 1997.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  859. 3D-fast spin echo法を用いた小脳橋角部のMR cisternography

    東海総合画像医学研究会 

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    Event date: 1997

    Language:Japanese  

    Country:Japan  

  860. MR cisternography of the cerebellopontine angle using 3D Fast SE. International conference

    Naganawa S, Ito T, Fukatsu H,Ishigaki T,Kassai Y, Takai H, Miyazaki M

    RSNA 1996 

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    Event date: 1996.12

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  861. 3D-FSE法が有用であったLarge vestibular aqueduct syndromeの2例

    長縄慎二、安藤容子、深津 博、石垣武男、中島 務

    日本医学放射線学会第120回中部地方会 

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    Event date: 1996.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  862. Muli-thin slab 3D TOF MR angiographyの有用性―第一報―:撮影条件の最適化

    深津 博、長縄慎二、安藤容子、村瀬詠子、石垣武男、市ノ瀬神保

    日本医学放射線学会第120回中部地方会 

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    Event date: 1996.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  863. High-speed and high resolution MR imaging of the inner ear using ultra-long echo train length 3D fast spin echo sequence and half Fourier imaging. International conference

    Naganawa S, Fukatsu H, Ishigaki T, Nakashima T, Kassai Y, Takai H, Miyazaki M

    4th Annual Meeting ISMRM  

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    Event date: 1996.4 - 1996.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  864. 画像上、興味ある所件を呈した悪性リンパ腫の1例

    長縄慎二、遠藤登喜子、青山英昭、佐藤康弘、市原周

    第5回日本乳癌画像研究会 

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    Event date: 1996.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  865. 従来型CT装置における造形剤投与法の腹部域での検討

    東海総合画像医学研究会 

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    Event date: 1996

    Language:Japanese  

    Country:Japan  

  866. Visualization of the internal anatomy for the inner ear using a long echo train length 3D fast spin echo sequence. International conference

    Naganawa S, Yamakawa K, Fukatsu H, Ishigaki T, Aoki I, Takai H, Miyazaki M

    3rd Annual Meeting and Exhibition ISMRM 

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    Event date: 1995.8

    Language:English   Presentation type:Oral presentation (general)  

    Country:France  

  867. High resolution T2-weighted image of the inner ear with 3D-fast spin echo sequence (3D-FSE). International conference

    Naganawa S, Senda K, Yamakawa K, Fukatsu H, Ishigaki T, Nakashima T, Sugimoto H, Aoki I, Ninomiya A, Takai H

    ECR1995 

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    Event date: 1995.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Austria  

  868. High resolution MR imaging of the inner ear using 3D-ESE

    Nippon Acta Radiologica 

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    Event date: 1995

    Language:Japanese  

    Country:Japan  

  869. MRI of the vestibular aquaduct

    Nippon Acta Radiologica 

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    Event date: 1991

    Language:English  

  870. 耳管機能検査―耳管造影dynamic CTの試み―

    長縄慎二、田所匡典、浅井英彰、石垣武男、佐久間貞行、丹羽英人、柳田則之

    第100回日本医学放射線学会中部地方会、第23回日本核医学会中部地方会、合同学術集会 

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    Event date: 1990.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  871. MRIで脊髄動静脈奇形と類似したartifactを認めた症例の検討

    石口恒男、長縄慎二、伊藤茂樹、田所匡典、浅井英彰、伊藤健吾、石垣武男、佐久間貞行、真下伸一

    第100回日本医学放射線学会中部地方会、第23回日本核医学会中部地方会、合同学術集会 

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    Event date: 1990.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  872. n-butyl-cyanoacrilateによる経カテーテル塞栓術

    石口恒男、長縄慎二、伊藤茂樹、田所匡典、堀川よしみ、伊藤健吾、石垣武男、佐久間貞行

    第99回日本医学放射線学会中部地方会 

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    Event date: 1990.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:豊明   Country:Japan  

  873. エタノールによる塞栓術後に腸間膜出血を生じた腎細胞癌の一例 

    長縄慎二、田所匡典、堀川よしみ、伊藤健吾、石口恒男、石垣武男、佐久間貞行、坂田孝雄、丸山邦弘

    第5回中部IVR研究会 

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    Event date: 1990.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:豊明   Country:Japan  

  874. 内耳のMRI―前庭水管撮像の試み―

    長縄慎二、山川耕二、浅井英彰、石口恒男、石垣武男、佐久間貞行

    第98回日本医学放射線学会中部地方会 

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    Event date: 1988.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  875. CTテクスチャ解析を用いた局所進行直腸癌における術前化学療法の治療効果予測の検討 International conference

    石垣聡子, 川井 恒, 田岡俊昭, 二橋尚志, 佐竹弘子, 上原, 長縄慎二

    第76回日本医学放射線学会総会  2017.4.13 

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    Venue:横浜  

  876. Computer-Aided Volumetry of the Three-Dimensional Solid Component Size in Part-solid Lung Cancer: Correlation with Prognosis.

    Shinichiro Kamiya, Shingo Iwano, Hiroyasu Umakoshi, Rintaro Ito, Shinji Naganawa

    103rd Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA)  2017.11.26 

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    Language:English   Presentation type:Poster presentation  

    Venue:Chicago, USA  

  877. Closing Remarks

    Shinji Naganawa

    2017.3.1 

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    Venue:Vienna, Austria  

  878. Accuracy of Clinical Staging for Small-sized Lung Cancer by Multi-detector Row CT and PET/CT.

    Hiroyasu Umakoshi, Shingo Iwano, Kohei Yokoi, Takayuki Fukui, Koji Kawaguchi, Rintaro Ito, Hironori Shimamoto, Shinji Naganawa

    World Congress Thoracic Imaging Boston  2017.6.18 

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  879. A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological.

    intaro Ito, Shingo Iwano, Hironori Shimamoto, Hiroyasu Umakoshi, Shinji Ito, Katsuhiko Kato, Shinji Naganawa

    European Congress of Radiology 2017(ECR)  2017.3.1 

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    Venue:Vienna, Austria  

  880. Delayed FLAIRでの迷路信号の左右非対称 International conference

    長縄慎二, 川井 恒, 中根俊樹, 田岡俊昭, 曽根三千彦

    第76回日本医学放射線学会総会  2017.4.13 

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    Venue:横浜  

  881. 造影Dual-energy CTによる原発性肺癌の局所浸潤性予測:腺癌と扁平上皮癌の比較 International conference

    岩野信吾, 伊藤倫太郎, 島本宏矩, 馬越弘泰, 長縄慎二

    第76回日本医学放射線学会総会  2017.4.13 

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    Venue:横浜  

  882. 腎静脈に発生した平滑筋肉腫の2例 International conference

    林 葉子, 松島正哉, 長縄慎二, 松尾かずな, 後藤百万

    第81回東海総合画像医学研究会  2017.1.7 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋  

  883. 胸壁並行断面CTによる間質性肺炎の経時的評価 International conference

    馬越弘泰, 岩野信吾, 伊藤倫太郎, 島本宏矩, 長縄慎二

    第9回呼吸機能イメージング研究会学術集会  2017.1.27 

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    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都  

  884. 肝被膜下血腫による肝コンパートメント症候群に対し血管塞栓術と血腫腫ドレナージを施行した1例 International conference

    伊藤 準, 松島正哉, 馬越弘泰, 長坂 憲, 駒田智大, 鈴木耕次郎, 長縄慎二, 石津洋二

    第61回中部IVR研究会  2017.2.25 

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    Venue:三重  

  885. 社内招聘勉強会での講師 International conference

    長縄慎二

    富士製薬工業(株) 社内招聘勉強会  2017.2.2 

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    Venue:東京  

  886. 早期声門癌の個別化された治療方針とその治療成績 International conference

    木村香菜, 伊藤善之, 岡田 徹, 久保田誠司, 川村麻里子, 中原理絵, 大家祐実, 香西由加, 高瀬裕樹, 長縄慎二, 藤本保志, 平松真理子, 西尾直樹, 都築秀典

    第34回東海頭頸部腫瘍研究会  2017.2.18 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋  

  887. 子宮頸部小細胞癌21例の臨床的検討 International conference

    川村麻里子, 伊藤善之, 岡田 徹, 久保田誠司, 木村香菜, 香西由加, 高瀬裕樹, 長縄慎二, 内海 史, 吉川史隆

    日本医学放射線学会 第161回中部地方会  2017.2.25 

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    Venue:三重  

  888. 多施設共同研究:1回2.25GyによるⅠ期声門癌の放射線治療 International conference

    伊藤善之, 久保田誠司, 中原理絵, 川村麻里子, 長縄慎二, 野本由人, 村尾豪之, 山川耕二, 石原俊一, 平澤直樹, 浅野晶子, 柳川繁雄

    日本医学放射線学会第162回中部地方会  2017.7.8 

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    Venue:富山  

  889. 多施設共同研究―第3報 Ⅰ期声門癌の1回2.25Gyによる放射線治療の実態調査 International conference

    伊藤善之, 久保田誠司, 野本由人, 村尾豪之, 山川耕二, 石原俊一, 浅野晶子, 平澤直樹, 川村麻里子, 柳川繁雄, 長縄慎二

    第34回東海頭頸部腫瘍研究会  2017.2.18 

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    Venue:名古屋  

  890. 原発性肺癌の術前臨床病期診断の正確性 International conference

    岩野信吾, 馬越弘泰, 伊藤倫太郎, 島本宏矩, 長縄慎二

    日本医学放射線学会 第161回中部地方会  2017.2.25 

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    Venue:三重  

  891. 乳がん術中照射部位の経時的変化 International conference

    川村麻里子, 伊藤善之, 久保田誠司, 岡田 徹, 大家祐実, 木村香菜, 香西由加, 高瀬裕樹, 佐竹弘子, 長縄慎二

    第76回日本医学放射線学会総会  2017.4.13 

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    Venue:横浜  

  892. トリプルネガティブ乳癌におけるダイナミックMRIの三次元的容積解析:生存との相関について International conference

    林 葉子, 佐竹弘子, 石垣聡子, 川村麻里子, 川井 恒, 長縄慎二

    第76回日本医学放射線学会総会  2017.4.13 

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    Venue:横浜  

  893. イピリムマブに伴う下垂体炎の3例 International conference

    加藤理恵子, 川井 恒, 田岡俊昭, 長縄慎二, 岩間信太郎

    日本医学放射線学会 第161回中部地方会  2017.2.25 

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    Venue:三重  

  894. びまん性星細胞腫と乏突起膠腫とのテクスチャ解析での鑑別 International conference

    川井 恒, 田岡俊昭, 中根俊樹, 櫻井康雄, 長縄慎二

    第54回日本磁気共鳴医学会大会  2017.9.14 

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    Venue:栃木  

  895. すりガラス影を有する肺癌における充実成分の3D半自動計測:予後との相関 International conference

    神谷晋一朗, 岩野信吾, 馬越弘泰, 伊藤倫太郎, 長縄慎二

    日本医学放射線学会第162回中部地方会  2017.7.8 

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    Venue:富山  

  896. Tract based DTI-ALPS法によるアルツハイマー病症例でのGlymphatic system評価の試み International conference

    田岡俊昭, 増谷佳孝, 川井 恒, 中根俊樹, 長縄慎二

    第76回日本医学放射線学会総会  2017.4.13 

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    Venue:横浜  

  897. The efficacy of percutaneous transhepatic portal vein embolozation using gelatin sponge particles and metallic coils.

    Tomohiro Komada, Kojiro Suzuki, Masaya Matsushima, Yoshine Mori, Ken Nagasaka, Hiroyasu Umakoshi, Tomoki Ebata, M Nagino, Shinji Naganawa

    European Congress of Radiology 2017(ECR)  2017.3.1 

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  898. Pattern difference in the area with T2-hyperintensity: comparison between gliomas and edemas by using texture analysis.

    Hisashi Kawai, Toshiaki Taoka, Toshiki Nakane, Yasuo Sakurai, Shinji Naganawa

    European Congress of Radiology 2017(ECR)  2017.3.1 

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    Venue:Vienna, Austria  

  899. Optimized treatment strategy for early glottic squamous cell carcinomas: An initial analysis.

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Seiji Kubota, Mariko Kawamura, Shinji Naganawa

    103rd Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA)  2017.11.26 

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    Venue:Chicago, USA  

  900. MP2RAGEを用いた視床内部構造の抽出 International conference

    中根俊樹, 田岡俊昭, 川井 恒, 加藤 裕, 櫻井康雄, 丸山克也, 長縄慎二

    第54回日本磁気共鳴医学会大会  2017.9.14 

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    Venue:栃木  

  901. MDCTとPET/CTによる肺癌ステージングの精度 International conference

    岩野信吾, 馬越弘泰, 伊藤倫太郎, 島本宏矩, 長縄慎二

    第76回日本医学放射線学会総会  2017.4.13 

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    Venue:横浜  

  902. Kinetic Volume Analysis on Dynamic Contrast-Enhanced MRI of Triple Negative Breast Cancer: Association with Survival Outcomes.

    Yoko Hayashi, Hiroko Satake, Satoko Ishigaki, Mariko Kawamura, Hisashi Kawai, Shinji Naganawa

    103rd Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA)  2017.11.26 

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    Venue:Chicago, USA  

  903. hT2w-3D-FLAIRシーケンスにおけるTR延長による低濃度ガドリニウム造影剤の信号値増加 International conference

    加藤 裕, 長縄慎二, 田岡俊昭, 川井 恒, 卜蔵公紀, 櫻井康雄

    第54回日本磁気共鳴医学会大会  2017.9.14 

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    Venue:栃木  

  904. How Does Gd Enter the Brain, When the BBB is Intact? Invited

    Shinji Naganawa

    International Society for Magnetic Resonance in Medicine 2017(ISMRM 2017)  2017.4.22  ISMRM2017

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    Venue:Honolulu, Hawai, USA  

  905. Glymphatic system評価に向けて:Gd造影剤静注4時間後の各液体腔信号の造影剤種間の比較 International conference

    長縄慎二, 川井 恒, 田岡俊昭

    第46回日本神経放射線学会  2017.2.17 

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    Venue:東京  

  906. Glymphatic system評価に向けて:DTI analysis along Perivascular Space(DTI-ALPS)でのAlzheimer症例の検討 International conference

    田岡俊昭, 増谷佳孝, 川井 恒, 中根俊樹, 長縄慎二

    第46回日本神経放射線学会  2017.2.17 

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    Venue:東京  

  907. Glymphatic systemの可視化に向けて International conference

    長縄慎二

    名古屋大学脳とこころの研究センター 第二回 拡大ワークショップ  2017.9.28 

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    Venue:名古屋  

  908. Glymphatic systemとMRI:内リンパ水腫やガドリニウム脳蓄積との関連 International conference

    長縄慎二

    第46回日本神経放射線学会  2017.2.17 

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    Venue:東京  

  909. Glymphatic SystemとMRI

    長縄慎二

    第63回九州MRI研究会  2018.1.6 

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    Venue:福岡  

  910. FDG-PETによる非小細胞肺癌の予後予測因子の検討:SUVmaxと体積を考慮した指標の比較 International conference

    伊藤信嗣, 岩野信吾, 伊藤倫太郎, 長縄慎二, 加藤克彦

    日本核医学会 第84回中部地方会  2017.2.25 

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    Venue:三重  

  911. Evaluating Glymphatic System by Diffusion Images: Alzheimer's Disease Cases Analyzed by Diffusion Tensor Image Analysis Along Perivascular Space(DTI-ALPS).

    Toshiaki Taoka, Yoshitaka Masutani, Hisashi Kawai, Toshiki Nakane, Kiwamu Matsuoka, Fumihiko Yasuno, Shinji Naganawa

    International Society for Magnetic Resonance in Medicine 2017(ISMRM 2017)  2017.4.22 

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    Venue:Honolulu, Hawai, USA  

  912. 内耳疾患についての臨床講演会 講師 International conference

    長縄慎二

    内耳疾患についての臨床講演会  2017.1.12 

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  913. MRIでめまいを見る

    長縄慎二

    名古屋大学脳とこころの研究センター 市民公開講座 総合テーマ「脳とこころの病気の予防と治療に向けて」  2018.1.21 

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    Venue:名古屋  

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Other research activities 1

  1. Guest editor; Frontiers in Surgery ; Hydropic Ear Disease: Imaging and Functional Evaluation, 2020-2021, edited by Shinji Naganawa with Robert Gurkov, Bielefeld University, Germany and Ilmary Pyykko, Tampere University, Finland. (19 articles by 106 authors.)

    2020.1
    -
    2021

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    Guest editor; Frontiers in Surgery ; Hydropic Ear Disease: Imaging and Functional Evaluation, 2020-2021, edited by Shinji Naganawa with Robert Gurkov, Bielefeld University, Germany and Ilmary Pyykko, Tampere University, Finland. (19 articles by 106 authors.)

Research Project for Joint Research, Competitive Funding, etc. 2

  1. 難治性平衡機能障害に関する調査研究

    2014.4 - 2015.3

    科学技術振興調整費 

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    Grant type:Competitive

  2. インターネットを用いた放射線医学共同研究の試み

    2001

    財団法人 堀情報科学振興財団研究助成金 

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    Grant type:Competitive

    突発性難聴の超高磁場MRIによる病態解明研究における医療情報のインターネット共有による研究推進

KAKENHI (Grants-in-Aid for Scientific Research) 22

  1. Classification and Evaluation of Cerebral White Matter Lesions on MRI: Understanding White Matter Lesions as Interstitial Fluidopathy

    Grant number:24K10855  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  2. Early detection of pre-symptomatic conditions through evaluation of vascular permeability and waste excretion function in the brain and sensory organs

    Grant number:23K27545  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\18590000 ( Direct Cost: \14300000 、 Indirect Cost:\4290000 )

  3. Early diagnosis before onset of disease pioneered by the evaluation of vascular permeability and waste excretion function for the brain and sensory organs

    Grant number:23H02854  2023.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\18590000 ( Direct Cost: \14300000 、 Indirect Cost:\4290000 )

  4. To redefine blood-brain-barrier (BBB)

    Grant number:18K19510  2018.6 - 2021.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    Naganawa Shinji

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    Authorship:Principal investigator 

    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

    To redefine blood-brain-barrier (BBB), we used advanced MRI techniques that were developed by us. We utilized extremely sensitive pulse sequences, which visualize ultra-low concentration gadolinium-based contrast agent (GBCA) in fluid. In human subjects, we found that intravenously injected GBCA slightly leaks to brain parenchyma of the subjects with normal BBB. Leaked GBCA exit brain through parevenous pial sheath to meningeal lymphatics along superior sagittal sinus. This leakage is closely related to aging and cyst formation along cortical veins. We also found that the age dependence of GBCA leakage to CSF is more prominent in ventricular CSF than in subarachnoid space of the brain surface. The results of this project were greatly influence the future research of BBB, drug delivery system and neurodegenerative disease.

  5. 内耳老廃物排泄機構に 着目した新機軸脳神経臨床画像診断の確立

    2017.4

    科学研究費補助金  基盤研究(B), 課題番号:17H04259

    長縄慎二

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    Authorship:Principal investigator 

  6. 内耳老廃物排泄機構に 着目した新機軸脳神経臨床画像診断の確立

    2017.4

    科学研究費助成事業  基盤研究(B), 課題番号:17H04259

    長縄慎二

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    Authorship:Principal investigator  Grant type:Competitive

  7. MR strategies to solve problems after endovascular aortic repair.

    Grant number:17K10398  2017.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Takehara Yasuo

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Endovascular aneurysm repair (EVAR) has become a viable alternative to conventional surgical open repair owing to its perioperative survival benefit; however, EVAR is associated with a unique complication called endoleak (EL), which continues to perfuse and pressurize the aneurysm sac and cause aneurysm enlargement and rupture.
    Type I and type III endoleak were more detectable with MR angiography and streamline analysis with 4D Flow within the aneurysm. A comprehensive analysis of concurrent multiple T2EL vessels using 4D-flow MRI may enable prediction of the sac expansion after EVAR by larger amplitude of the flow velocity in the branch arteries.

  8. Evaluation of glymphatic system in the human brain using diffusion MR images and application to Alzheimer's disease.

    Grant number:17K10397  2017.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Taoka Toshiaki

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    In the current study, we hypothesized that diffusivity limited to the direction of perivascular space correlates with activity of the Glymphatic system. We developed a method called "diffusion tensor image analysis along the perivascular space (DTI-ALPS)" as a method to evaluate the movement of water molecules in deep white matter from diffusion tensor images. In this method, the diffusivity in the perivascular space in the white matter outside the lateral ventricle was evaluated using the ratio to the diffusivity in the orthogonal direction(ALPS index). In the evaluation of Alzheimer's disease cases, the ALPS index was significantly inversely correlated with the MMSE score. This suggests that the ALPS index may be an index that reflects the function of the Glymphatic system.

  9. Development of new dimensional clinical neuroimaging method based on the waste clearance system of inner ear

    Grant number:17H04259  2017.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Naganawa Shinji

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    Authorship:Principal investigator 

    Grant amount:\13390000 ( Direct Cost: \10300000 、 Indirect Cost:\3090000 )

    We have developed new MR pulse sequences that have extremely high sensitivity to low concentration gadolinium based contrast agent. Then we applied them to the patients with the suspicion of endolymphatic hydrops in the inner ear. We found and reported that the leakage of gadolinium to cerebrospinal fluid around cortical veins in the patients older than 37-years-old. As we accumulate many patients' data, we experienced some exceptional cases who shows leakage from younger period. Also we experienced the subjects without leakage in oldr subjects. We exnamined 190 cases, finally, we could find the cut-off value of 37.3-years-old from the receiver operating curve analysis. We have published this result on the journal "Magnetic Resonance in Medical Sciences". These results are gathering many attentions from neuroscience community as the objective biomaker of brain aging.

  10. depelopment of low invasive imaging evaluation for human glymphatic system

    Grant number:16K10312  2016.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kawai Hisashi

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    We were able to indicate the leakage of Gadolinium-based contrast agent (GBCA) into the subarachnoid space around the cortical veins with MRI obtained after intravenous injection of GBCA.And intravenously administered GBCA leaks into the subarachnoid space around the cortical veins in most patients over 37 years of age. However, it should be noted that it can be found occasionally in patients under 37 years of age.

  11. From elderly person to children, evaluating development and aging from the viewpoint of functional MRI and physiological indicators

    Grant number:16K10313  2016.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Nakane Toshiki

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    We measured, analyzed, and evaluated the relationship between the data obtained from physiological indices such as heart rate variability and the neural activity calculated from brain functional images. Regarding heartbeat, it is a factor that causes imaging artifacts in daily clinical image examination, but this time we analyzed brain functional images in relation to the aspect of the autonomic nervous system calculated from it. It was observed that resting brain activity formed networks known as the default mode network. The relationship with heart rate is currently under investifation.

  12. Multipalametric imaging of bile duct cancer

    Grant number:16K10276  2016.4 - 2020.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kojiro Suzuki

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    The CT imagings of bile duct cancer were evaluated in this study. Compared the contrast effect of perihilar bile duct cancer with normal liver parenchyma and bile duct, the pancreatic phase imagings were superior to arterial phase, portal-venous phase, and delayed phase. On the other hand, the contrast effect in distal bile duct cancer, the difference of the CT valued was most large in the imagings of delayed phase. On visual evaluation, the portal-venous phase was most superior, and arterial phase was second one. On the other hand, some cases were most clearly visualized in the delayed phase imagings. In the evaluation of the virtual monochromatic imagings, the spread of longitudinally and vertically spread.

  13. Risk quantification and stratification in host and tumor of breast cancer by spectral mammography and MRI

    Grant number:15K09888  2015.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Satake Hiroko

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    The correlation between the amount of fibrograndular breast tissue and breast density calculated by spectral mammography and the background parenchymal enhancement of breast MRI was compared. Breast density showed most frequently class III during four classifications, and their occupancy was higher in the cases with follow-up of benign changes.There was no correlation between the background parenchymal enhancement and the score of breast density.
    On the other hand, we performed quantitative analysis on dynamic contrast-enhanced MRI of breast cancer and compared it with histopathological prognostic factors, and survival.Triple-negative breast cancer showed heterogeneous distributions of quantitative parameters in the tumor by histogram analysis, and evaluation using a computer-aided system showed correlation between imaging features and survival.

  14. Exploratory research of microscopic myocardial injury by irradiation using averaged electrocardiogram

    Grant number:26461883  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Tohru Okada

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    In this study, to explore myocardial damage due to irradiation, we use averaged electrocardiogram that can identify microscopic myocardial injury. Interventions other than the above were judged to deviate from regular medical practice, therefore this study was approved in our hospital as a prospective clinical trial considerably later than the original schedule. About 40% of the case arrival number (30 cases) was accumulated and analyzed as much as possible this time. No significant change was observed by irradiation with fQRS-d, RMS 40ms, LAS 40μV which are indicators of the averaged electrocardiogram. In E/e’ which is an index of diastolic cardiac function at echocardiogram, an upward trend was observed after 6 months of irradiation, although a statistically significant difference was not observed. This study will continue as an in-hospital clinical trial and accumulate cases and plan to reanalyze as soon as the number of cases is reached.

  15. メニエール病におけるめまい発作発生機構の先端画像診断技術による解明

    2013.4 - 2017.3

    科学研究費補助金  基盤研究(B),課題番号:25293263

    長縄 慎二

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    Authorship:Principal investigator 

  16. Elucidation of mechanism for the occurence of vertigo attacks in Meniere's disease by advanced diagnositic imaging techniques

    Grant number:25293263  2013.4 - 2017.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Naganawa Shinji

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\13650000 ( Direct Cost: \10500000 、 Indirect Cost:\3150000 )

    Meniere's disease is a benign disease whose symptom is a vertigo attack, but in reality it deprives the social life of so many people. There are still no definitive diagnostic methods and treatments yet. We have pioneered the development of the method and evaluation method for the endolymphatic hydrops of Meniere's disease by MRI and established the objective diagnostic method ahead of the world. A number of powerful estimation models have been proposed for several years. The purpose of this study was to explore the mechanism of occurrence of attacks by developing and applying advanced image technology, to evaluate the appropriateness of estimation model, and to contribute to the elucidation of the essence of vertigo occurrence mechanism of this disease. And with our research, we could almost identify the key finding correlating vertigo attacks. The keys are the saccular endolymphatic hydrops and impaired glymphatic function.

  17. 人体内各種液体空間での薬物動態可視化と定量化のための超高感度磁気共鳴診断技術開発

    2012.4 - 2015.3

    科学研究費補助金  挑戦的萌芽研究

    長縄慎二

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    Authorship:Principal investigator 

  18. メニエール病診療に革新的進歩をもたらす先端磁気共鳴画像診断法の開発と確立

    2010.4 - 2013.3

    科学研究費補助金  基盤研究(B),課題番号:22390233

    長縄 慎二

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    Authorship:Principal investigator 

  19. 転移性脳腫瘍検出と治療に有用な高精度3次元スピンエコー新規磁気共鳴撮像法の確立

    2007

    科学研究費補助金  基盤研究(B)(一般),課題番号:19390318

    長縄 慎二

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    Authorship:Principal investigator 

  20. 高次脳機能障害を伴う外傷性微少脳損傷の客観的画像診断法の確立

    2004

    科学研究費補助金  基盤研究(C),課題番号:16591199

    長縄 慎二

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    Authorship:Principal investigator 

  21. 人工内耳手術における内視鏡の開発

    2001 - 2003

    科学研究費補助金  厚生労働省感覚器障害研究事業

    曾根三千彦

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    Authorship:Coinvestigator(s) 

  22. 内耳性難聴、耳鳴、めまいに対する局所治療に関する研究 内リンパ管拡張症に関する研究

    1999 - 2001

    科学研究費補助金  文部省科学研究費

    中島務

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    Authorship:Coinvestigator(s) 

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Teaching Experience (Off-campus) 1

  1. 医工連携

    2007.4 - 2008.3 名古屋工業大学)