Updated on 2021/11/02

写真a

 
NAGANAWA, Shinji
 
Organization
Graduate School of Medicine Program in Integrated Medicine Advanced Medical Science Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
Contact information
メールアドレス

Degree 1

  1. Doctor of Medicine ( 1998.3   Nagoya University ) 

Research Interests 3

  1. magnetic resonance imaging, functional brain imaging, diffusion weighted image, inner ear

  2. magnetic resonance imaging endolymphatic hydrops glymphatic system

  3. inner ear

Research Areas 2

  1. Others / Others  / Radiation Science

  2. Life Science / Radiological sciences

Current Research Project and SDGs 1

  1. Study on high resolution MRI of the inner ear

Research History 4

  1. Nagoya University   Brain and Mind Research Center   Director in General

    2015.4 - 2019.3

  2. Nagoya University

    2006.7

  3. Nagoya University   Professor

    2006.7

  4. Nagoya University

    2006.7

Education 1

  1. Nagoya University   Faculty of Medicine

    - 1987

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    Country: Japan

Professional Memberships 7

  1. 日本医学放射線学会   理事

    2016.4 - 2022.3

  2. 日本磁気共鳴医学会   代議員

    2019.4 - 2021.9

  3. 日本医学放射線学会   代議員

    2010.4 - 2022.3

  4. Radiological Society of North America

  5. International Society of Magnetic Resonance in Medicine

  6. 日独放射線医学交流計画   代表幹事 (日本側)

    2018.9

  7. International Society of Magnetic Resonance in Medicine

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Committee Memberships 1

  1.   安全保障委員  

       

Awards 26

  1. 2020 MRMS Distinguished Reviewer

    2021.10   2020 MRMS Distinguished Reviewer

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    Award type:Honored in official journal of a scientific society, scientific journal 

  2. MRMS(Magnetic Resonance in Medical Sciences) 創刊20周年最優秀論文賞

    2021.9   (一社) 日本磁気共鳴医学会  

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    Award type:Honored in official journal of a scientific society, scientific journal 

  3. 日本磁気共鳴医学会優秀論文賞

    2021.9   (一社) 日本磁気共鳴医学会  

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    Award type:Award from Japanese society, conference, symposium, etc. 

  4. 2020 ISMRM (International Society for Magnetic Resonance in Medicine) Fellows of the Society (senior fellow)

    2020.8   ISMRM virtual conference  

    Shinji Naganawa

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    Award type:International academic award (Japan or overseas)  Country:Japan

  5. MAGNA CUM LAUDE Radiographer Poster Award

    2019.2   European Conference of Radiology (ECR) 2019   Assessment of the severity in chronic thromboembolic pulmonary hypertension by quantitative parameters of dual-energy CT.

    Yoshinori Tsutsumi, Shingo Iwano, Naoki Okumura, Shiro Adachi, Shinji Abe, Takahisa Kondo, Shinji Naganawa, Katsuhiko Kato

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    Award type:Award from international society, conference, symposium, etc.  Country:Austria

  6. 一般社団法人日本めまい平衡医学会 60周年記念理事長表彰

    2018.11   一般社団法人日本めまい平衡医学会  

    長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  7. 2018年度日本磁気共鳴医学会優秀論文賞

    2018.9   一般社団法人 日本磁気共鳴医学会  

    長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  8. 平成28年度Japanese Journal of Radiology、Most often cited papers

    2017.4   公益社団法人日本医学放射線学会  

    長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  9. JJR Excellent Reviewer Award in 2015

    2016.4  

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    Country:Japan

  10. 第45回日本神経放射線学会 優秀症例展示賞(眼球内シリコンオイルの頭蓋内迷入の2例)

    2016.2   第45回日本神経放射線学会   (眼球内シリコンオイルの頭蓋内迷入の2例)

    川井 恒、田岡俊昭、中根俊樹、櫻井康雄、佐竹弘子、長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc. 

  11. 第45回日本神経放射線学会 最優秀口演賞(「Glioblastomaらしさ」とは何か?:テクスチャ解析による定量の試み)

    2016.2   第45回日本神経放射線学会   「Glioblastomaらしさ」とは何か?:テクスチャ解析による定量の試み

    田岡俊昭、川井 恒、中根俊樹、長縄慎二

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    Award type:Award from Japanese society, conference, symposium, etc. 

  12. Certificate of Merit

    2015.12   RSNA  

    Toshiaki Taoka, Akio Fukusumi, Toshiteru Miyasaka, Takeshi Wada, Kimihiko Kichikawa, Shinji Naganawa, Tomoko Ochi, Hisashi Kawai

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    Award type:International academic award (Japan or overseas)  Country:United States

  13. BEST ORAL PRESENTATION IN AOCMP 2015

    2015.11   15th Asia-Oceania Congress of Medical Physics  

    Takeshi Kamomae, Masataka Oita, Naoki Hayashi, Motoharu Sasaki, Hideki Aoyama, Yoshiyuki Itoh, Shinji Naganawa

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    Country:Japan

  14. 2014 MRMS Distinguished Reviewer Award

    2015.9  

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    Country:Japan

  15. 第74回日本医学放射線学会総会CyPos賞

    2015.4   第74回日本医学放射線学会総会  

    久保田誠司、伊藤善之、副松由加、野本由人、村尾豪之、山川耕二、石原俊一、平澤直樹、浅野晶子、長縄慎二

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    Country:Japan

    久保田誠司、伊藤善之、副松由加、野本由人、村尾豪之、山川耕二、 石原俊一、平澤直樹、浅野晶子、長縄慎二     I期声門癌に対する1回2.25Gyを用いた寡分割照射例の多施設調査

  16. 第10回「画像診断」Best Invited Editor賞

    2014.4   秀潤社  

    長縄慎二

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    Country:Japan

  17. 13th Asia-Oceania Congress of Medical Physics & 11th South-East Asian Congress of Medical Physics,Best Poster Award(Radiotherapy)

    2013.12   13th Asia-Oceania Congress of Medical Physics & 11th South-East Asian Congress of Medical Physics  

    Takeshi Kamomae, Yoshiyuki Itoh, Kuniyasu Okudaira, Masashi Tomida, Takayoshi Nakaya, Yoshikazu Miyake, Hiroshi Oguchi, Masataka Komori, Tohru Okada, Shinji Naganawa

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    Country:Singapore

  18. 2012 Robert and Elma Kemp Harper Prize

    2013.10   Clinical Radiology  

    Hiroshi Ogawa, Shigeki Itoh, Tetsuro Nagasaka, Kojiro Suzuki, Toyohiro Ota, Shinji Naganawa

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    Country:United Kingdom

  19. 第72回日本医学放射線学会総会 教育展示優秀賞

    2013.4   日本医学放射線学会  

    長縄慎二、山崎雅弘、川井 恒、中島 務

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    Country:Japan

    Objective diagnosis of Meniere´s disease by clinically applicable method:How to do it メニエール病のMRIによる簡便な客観診断法;How to do it

  20. BEST POSTER ON OTOLOGY,NEURO OTOLOGY AND SKULL BASE SURGERY

    2009.6  

    Tsutomu Nakashima, Shinji Naganawa, Naomi Katayama, Masaki Teranishi, Seiichi Nakata, Makoto Sugihara, Michihiko Sone, Sachiko Kasai, Mayumi Yoshioka, Masako Yamamoto, Tadao Yoshida, Hirokazu Suzuki

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    Award type:Award from international society, conference, symposium, etc. 

  21. certificate of merit

    2008.11   RSNA2008  

  22. Gold medal (日本医学放射線学会)

    2008.4   日本医学放射線学会  

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    Country:Japan

  23. Gold medal

    2007.4  

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    Country:Japan

  24. certificate of merit(ヨーロッパ放射線学会)

    2004.3   European Congress of Radiology  

  25. Cum Laude(北米放射線学会)

    1996  

  26. certificate of appreciation(ヨ-ロッパ放射線学会)

    1995  

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Papers 632

  1. Imaging diagnosis of autoimmune pancreatitis: computed tomography and magnetic resonance imaging.

    Ogawa H, Takehara Y, Naganawa S

    Journal of medical ultrasonics (2001)     2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10396-021-01145-8

    PubMed

  2. Radiomics in breast MRI: current progress toward clinical application in the era of artificial intelligence.

    Satake H, Ishigaki S, Ito R, Naganawa S

    La Radiologia medica     2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11547-021-01423-y

    PubMed

  3. Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus.

    Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G

    iScience   Vol. 24 ( 10 ) page: 103106   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.isci.2021.103106

    PubMed

  4. Peripheral Retinal Leakage after Intravenous Administration of a Gadolinium-based Contrast Agent: Age Dependence, Temporal and Inferior Predominance and Potential Implications for Eye Homeostasis.

    Naganawa S, Ito R, Kawamura M, Taoka T, Yoshida T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2463/mrms.mp.2021-0100

    PubMed

  5. The importance of choosing the right strategy to treat small cell carcinoma of the cervix: a comparative analysis of treatments.

    Kawamura M, Koide Y, Murai T, Ishihara S, Takase Y, Murao T, Okazaki D, Yamaguchi T, Uchiyama K, Itoh Y, Kodaira T, Shibamoto Y, Mizuno M, Kikkawa F, Naganawa S

    BMC cancer   Vol. 21 ( 1 ) page: 1046   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12885-021-08772-x

    PubMed

  6. Features from MRI texture analysis associated with survival outcomes in triple-negative breast cancer patients.

    Kamiya S, Satake H, Hayashi Y, Ishigaki S, Ito R, Kawamura M, Taoka T, Iwano S, Naganawa S

    Breast cancer (Tokyo, Japan)     2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12282-021-01294-1

    PubMed

  7. Changes in Vessel Wall Enhancement Related to the Recent Neurological Symptoms in Patients with Moyamoya Disease.

    Muraoka S, Taoka T, Kawai H, Okamoto S, Uda K, Naganawa S, Araki Y

    Neurologia medico-chirurgica   Vol. 61 ( 9 ) page: 515 - 520   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmc.oa.2021-0058

    PubMed

  8. Labyrinthitis With Endolymphatic Hydrops Revealed by Imaging Analysis in a Case With Severe Postoperative Complications Following Stapes Surgery.

    Kobayashi M, Yoshida T, Uchida Y, Sugimoto S, Naganawa S, Sone M

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology     2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MAO.0000000000003328

    PubMed

  9. Evaluation of the blood-perilymph barrier in ears with endolymphatic hydrops.

    Yoshida T, Kobayashi M, Sugimoto S, Teranishi M, Naganawa S, Sone M

    Acta oto-laryngologica   Vol. 141 ( 8 ) page: 736 - 741   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/00016489.2021.1957500

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  10. Distribution of Gadolinium-based Contrast Agent after Leaking into the Cerebrospinal Fluid: Comparison between the Cerebral Cisterns and the Lateral Ventricles.

    Ohashi T, Naganawa S, Iwata S, Kuno K

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 2 ) page: 175 - 181   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2463/mrms.mp.2020-0016

    PubMed

  11. Dosimetric impacts of beam-hardening filter removal for the CyberKnife system.

    Kamomae T, Matsunaga T, Suzuki J, Okudaira K, Kawabata F, Kato Y, Oguchi H, Shimizu M, Sasaki M, Takase Y, Kawamura M, Ohtakara K, Itoh Y, Naganawa S

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)   Vol. 86   page: 98 - 105   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejmp.2021.05.011

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  12. Age-related changes in the distribution of intravenously administered gadolinium-based contrast agents leaked into the cerebrospinal fluid in patients with suspected endolymphatic hydrops.

    Ohashi T, Naganawa S, Iwata S, Kuno K

    Japanese journal of radiology   Vol. 39 ( 5 ) page: 433 - 441   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11604-020-01079-0

    Web of Science

    PubMed

  13. Early glottic cancer treatment with concurrent chemoradiotherapy with once-daily orally administered S-1.

    Takase Y, Itoh Y, Ohtakara K, Kawamura M, Ito J, Oie Y, Ono T, Sasaki Y, Nishida A, Naganawa S

    Nagoya journal of medical science   Vol. 83 ( 2 ) page: 251 - 258   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.83.2.251

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  14. Cross-sectional Area of the Superior Petrosal Sinus is Reduced in Patients with Significant Endolymphatic Hydrops.

    Naganawa S, Ito R, Kawai H, Kawamura M, Taoka T, Yoshida T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2463/mrms.mp.2021-0010

    PubMed

  15. MR Imaging of Endolymphatic Hydrops in Five Minutes.

    Naganawa S, Ito R, Kawai H, Kawamura M, Taoka T, Sakai M, Ichikawa K, Yoshida T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2463/mrms.ici.2021-0022

    PubMed

  16. Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics.

    Taoka T, Naganawa S

    Japanese journal of radiology   Vol. 39 ( 1 ) page: 1 - 14   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s11604-020-01017-0

    Web of Science

    PubMed

  17. Novel Magnetic Resonance Imaging-Based Method for Accurate Diagnosis of Meniere's Disease.

    Ito T, Inoue T, Inui H, Miyasaka T, Yamanaka T, Kichikawa K, Takeda N, Kasahara M, Kitahara T, Naganawa S

    Frontiers in surgery   Vol. 8   page: 671624   2021

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fsurg.2021.671624

    PubMed

  18. The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging.

    Naganawa S, Taoka T

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2463/mrms.rev.2020-0122

    PubMed

  19. Neurofluid Dynamics and the Glymphatic System: A Neuroimaging Perspective

    Taoka Toshiaki, Naganawa Shinji

    KOREAN JOURNAL OF RADIOLOGY   Vol. 21 ( 11 ) page: 1199 - 1209   2020.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3348/kjr.2020.0042

    Web of Science

    PubMed

  20. Large expert-curated database for benchmarking document similarity detection in biomedical literature search

    Brown Peter, Tan Aik-Choon, El-Esawi Mohamed A., Liehr Thomas, Blanck Oliver, Gladue Douglas P., Almeida Gabriel M. F., Cernava Tomislav, Sorzano Carlos O., Yeung Andy W. K., Engel Michael S., Chandrasekaran Arun Richard, Muth Thilo, Staege Martin S., Daulatabad Swapna V., Widera Darius, Zhang Junpeng, Meule Adrian, Honjo Ken, Pourret Olivier, Yin Cong-Cong, Zhang Zhongheng, Cascella Marco, Flegel Willy A., Goodyear Carl S., van Raaij Mark J., Bukowy-Bieryllo Zuzanna, Campana Luca G., Kurniawan Nicholas A., Lalaouna David, Huttner Felix J., Ammerman Brooke A., Ehret Felix, Cobine Paul A., Tan Ene-Choo, Han Hyemin, Xia Wenfeng, McCrum Christopher, Dings Ruud P. M., Marinello Francesco, Nilsson Henrik, Nixon Brett, Voskarides Konstantinos, Yang Long, Costa Vincent D., Bengtsson-Palme Johan, Bradshaw William, Grimm Dominik G., Kumar Nitin, Martis Elvis, Prieto Daniel, Sabnis Sandeep C., Amer Said E. D. R., Liew Alan W. C., Perco Paul, Rahimi Farid, Riva Giuseppe, Zhang Chongxing, Devkota Hari P., Ogami Koichi, Basharat Zarrin, Fierz Walter, Siebers Robert, Tan Kok-Hian, Boehme Karen A., Brenneisen Peter, Brown James A. L., Dalrymple Brian P., Harvey David J., Ng Grace, Werten Sebastiaan, Bleackley Mark, Dai Zhanwu, Dhariwal Raman, Gelfer Yael, Hartmann Marcus D., Miotla Pawel, Tamaian Radu, Govender Pragashnie, Gurney-Champion Oliver J., Kauppila Joonas H., Zhang Xiaolei, Echeverria Natalia, Subhash Santhilal, Sallmon Hannes, Tofani Marco, Bae Taeok, Bosch Oliver, Cuiv Paraic O., Danchin Antoine, Diouf Barthelemy, Eerola Tuomas, Evangelou Evangelos, Filipp Fabian V., Klump Hannes, Kurgan Lukasz, Smith Simon S., Terrier Olivier, Tuttle Neil, Ascher David B., Janga Sarath C., Schulte Leon N., Becker Daniel, Browngardt Christopher, Bush Stephen J., Gaullier Guillaume, Ide Kazuki, Meseko Clement, Werner Gijsbert D. A., Zaucha Jan, Al-Farha Abd A., Greenwald Noah F., Popoola Segun I., Rahman Md Shaifur, Xu Jialin, Yang Sunny Y., Hiroi Noboru, Alper Ozgul M., Baker Chris I., Bitzer Michael, Chacko George, Debrabant Birgit, Dixon Ray, Forano Evelyne, Gilliham Matthew, Kelly Sarah, Klempnauer Karl-Heinz, Lidbury Brett A., Lin Michael Z., Lynch Iseult, Ma Wujun, Maibach Edward W., Mather Diane E., Nandakumar Kutty S., Ohgami Robert S., Parchi Piero, Tressoldi Patrizio, Xue Yu, Armitage Charles, Barraud Pierre, Chatzitheochari Stella, Coelho Luis P., Diao Jiajie, Doxey Andrew C., Gobet Angelique, Hu Pingzhao, Kaiser Stefan, Mitchell Kate M., Salama Mohamed F., Shabalin Ivan G., Song Haijun, Stevanovic Dejan, Yadollahpour Ali, Zeng Erliang, Zinke Katharina, Alimba C. G., Beyene Tariku J., Cao Zehong, Chan Sherwin S., Gatchell Michael, Kleppe Andreas, Piotrowski Marcin, Torga Gonzalo, Woldesemayat Adugna A., Cosacak Mehmet I., Haston Scott, Ross Stephanie A., Williams Richard, Wong Alvin, Abramowitz Matthew K., Effiong Andem, Lee Senhong, Abid Muhammad Bilal, Agarabi Cyrus, Alaux Cedric, Albrecht Dirk R., Atkins Gerald J., Beck Charles R., Bonvin A. M. J. J., Bourke Emer, Brand Thomas, Braun Ralf J., Bull James A., Cardoso Pedro, Carter Dee, Delahay Robin M., Ducommun Bernard, Duijf Pascal H. G., Epp Trevor, Eskelinen Eeva-Liisa, Fallah Mazyar, Farber Debora B., Fernandez-Triana Jose, Feyerabend Frank, Florio Tullio, Friebe Michael, Furuta Saori, Gabrielsen Mads, Gruber Jens, Grybos Malgorzata, Han Qian, Heinrich Michael, Helantera Heikki, Huber Michael, Jeltsch Albert, Jiang Fan, Josse Claire, Jurman Giuseppe, Kamiya Haruyuki, de Keersmaecker Kim, Kristiansson Erik, de Leeuw Frank-Erik, Li Jiuyong, Liang Shide, Lopez-Escamez Jose A., Lopez-Ruiz Francisco J., Marchbank Kevin J., Marschalek Rolf, Martin Carmen S., Miele Adriana E., Montagutelli Xavier, Morcillo Esteban, Nicoletti Rosario, Niehof Monika, O'Toole Ronan, Ohtomo Toshihiko, Oster Henrik, Palma Jose-Alberto, Paterson Russell, Peifer Mark, Portilla Maribel, Portillo M. C., Pritchard Antonia L., Pusch Stefan, Raghava Gajendra P. S., Roberts Nicola J., Ross Kehinde, Schuele Birgitt, Sergeant Kjell, Shen Jun, Stella Alessandro, Sukocheva Olga, Uversky Vladimir N., Vanneste Sven, Villet Martin H., Viveiros Miguel, Vorholt Julia A., Weinstock Christof, Yamato Masayuki, Zabetakis Ioannis, Zhao Xin, Ziegler Andreas, Aizat Wan M., Atlas Lauren, Bridges Kristina M., Chakraborty Sayan, Deschodt Mieke, Domingues Helena S., Esfahlani Shabnam S., Falk Sebastian, Guisado J. L., Kane Nolan C., Kueberuwa Gray, Lau Colleen L., Liang Dai, Liu Enwu, Luu Andreas M., Ma Chuang, Ma Lisong, Moyer Robert, Norris Adam D., Panthee Suresh, Parsons Jerod R., Peng Yousong, Pinto Ines Mendes, Reschke Cristina R., Sillanpaa Elina, Stewart Christopher J., Uhle Florian, Yang Hui, Zhou Kai, Zhu Shu, Ashry Mohamed, Bergsland Niels, Berthold Maximilian, Chen Chang-Er, Colella Vito, Cuypers Maarten, Eskew Evan A., Fan Xiao, Gajda Maksymilian, Gonzalezlez-Prendes Rayner, Goodin Amie, Graham Emily B., Groen Ewout J. N., Gutierrez-Sacristan Alba, Habes Mohamad, Heffler Enrico, Higginbottom Daniel B., Janzen Thijs, Jayaraman Jayakumar, Jibb Lindsay A., Jongen Stefan, Kinyanjui Timothy, Koleva-Kolarova Rositsa G., Li Zhixiu, Liu Yu-Peng, Lund Bjarte A., Lussier Alexandre A., Ma Liping, Mier Pablo, Moore Matthew D., Nagler Katja, Orme Mark W., Pearson James A., Prajapati Anilkumar S., Saito Yu, Troder Simon E., Uchendu Florence, Verloh Niklas, Voutchkova Denitza D., Abu-Zaid Ahmed, Bakkach Joaira, Baumert Philipp, Dono Marcos, Hanson Jack, Herbelet Sandrine, Hobbs Emma, Kulkarni Ameya, Kumar Narendra, Liu Siqi, Loft Nikolai D., Reddan Tristan, Senghore Thomas, Vindin Howard, Xu Haotian, Bannon Ross, Chen Branson, Cheung Johnny T. K., Cooper Jeffrey, Esnakul Ashwini K., Feghali Karine A., Ghelardi Emilia, Gnasso Agostino, Horbar Jeffrey, Lai Hei M., Li Jian, Ma Lan, Ma Ruiyan, Pan Zihang, Peres Marco A., Pranata Raymond, Seow Esmond, Sydes Matthew, Testoni Ines, Westermair Anna L., Yang Yongliang, Afnan Masoud, Albiol Joan, Albuquerque Lucia G., Amiya Eisuke, Amorim Rogerio M., An Qianli, Andersen Stig U., Aplin John D., Argyropoulos Christos, Asmann Yan W., Assaeed Abdulaziz M., Atanasov Atanas G., Atchison David A., Avery Simon V., Avillach Paul, Baade Peter D., Backman Lars, Badie Christophe, Baldi Alfonso, Ball Elizabeth, Bardot Olivier, Barnett Adrian G., Basner Mathias, Batra Jyotsna, Bazanova O. M., Beale Andrew, Beddoe Travis, Bell Melanie L., Berezikov Eugene, Berners-Price Sue, Bernhardt Peter, Berry Edward, Bessa Theolis B., Billington Craig, Birch John, Blakely Randy D., Blaskovich Mark A. T., Blum Robert, Boelaert Marleen, Bogdanos Dimitrios, Bosch Carles, Bourgoin Thierry, Bouvard Daniel, Boykin Laura M., Bradley Graeme, Braun Daniel, Brownlie Jeremy, Bruhl Albert, Burt Austin, Butler Lisa M., Byrareddy Siddappa N., Byrne Hugh J., Cabantous Stephanie, Calatayud Sara, Candal Eva, Carlson Kimberly, Casillas Sonia, Castelvetro Valter, Caswell Patrick T., Cavalli Giacomo, Cerovsky Vaclav, Chagoyen Monica, Chen Chang-Shi, Chen Dong F., Chen Hao, Chen Hui, Chen Jui-Tung, Chen Yinglong, Cheng Changxiu, Cheng Jianlin, Chinapaw Mai, Chinopoulos Christos, Cho William C. S., Chong Lillian, Chowdhury Debashish, Chwalibog Andre, Ciresi A., Cockcroft Shamshad, Conesa Ana, Cook Penny A., Cooper David N., Coqueret Olivier, Corea Enoka M., Costa Elisio, Coupland Carol, Crawford Stephanie Y., Cruz Aparecido D., Cui Huijuan, Cui Qiang, Culver David C., D'Angiulli Amedeo, Dahms Tanya E. S., Daigle France, Dalgleish Raymond, Danielsen Havard E., Darras Sebastien, Davidson Sean M., Day David A., Degirmenci Volkan, Demaison Luc, Devriendt Koenraad, Ding Jiandong, Dogan Yunus, Dong X. C., Donner Claudio F., Dressick Walter, Drevon Christian A., Duan Huiling, Ducho Christian, Dumaz Nicolas, Dwarakanath Bilikere S., Ebell Mark H., Eisenhardt Steffen, Elkum Naser, Engel Nadja, Erickson Timothy B., Fairhead Michael, Faville Marty J., Fejzo Marlena S., Festa Fernanda, Feteira Antonio, Flood-Page Patrick, Forsayeth John, Fox Simon A., Franks Steven J., Frentiu Francesca D., Frilander Mikko J., Fu Xinmiao, Fujita Satoshi, Galea Ian, Galluzzi Luca, Gani Federica, Ganpule Arvind P., Garcia-Alix Antonio, Gedye Kristene, Giordano Maurizio, Giunta Cecilia, Gleeson Paul A., Goarant Cyrille, Gong Haipeng, Gora Diop, Gough Michael J., Goyal Ravinder, Graham Kathryn E., Grande-Perez Ana, Graves Patricia M., Greidanus Harm, Grice Darren, Grunau Christoph, Gumulya Yosephine, Guo Yabin, Gurevich Vsevolod V., Gusev Oleg, Hacker Elke, Hage Steffen R., Hagen Guy, Hahn Steven, Haller Dagmar M., Hammerschmidt Sven, Han Jianwei, Han Renzhi, Handfield Martin, Hapuarachchi Hapuarachchige C., Harder Timm, Hardingham Jennifer E., Heck Michelle, Heers Marcel, Hew Khe F., Higuchi Yohei, St Hilaire Cynthia, Hilton Rachel, Hodzic Enisa, Hone Andrew, Hongoh Yuichi, Hu Guoku, Huber Heinz P., Hueso Luis E., Huirne Judith, Hurt Lisa, Idborg Helena, Ikeo Kazuho, Ingley Evan, Jakeman Philip M., Jensen Arne, Jia Hong, Jia Husen, Jia Shuqin, Jiang Jianping, Jiang Xingyu, Jin Yi, Jo Daehyun, Johnson Andrew M., Johnston Marie, Jonscher Karen R., Jorens Philippe G., Jorgensen Jens O. L., Joubert Johan W., Jung Sin-Ho, Junior Antonio M., Kahan Thomas, Kamboj Sunjeev K., Kang Yong-Kook, Karamanos Yannis, Karp Natasha A., Kelly Ryan, Kenna Ralph, Kennedy Jonathan, Kersten Birgit, Khalaf Roy A., Khalid Javaria M., Khatlani T., Khider Tarig, Kijanka Gregor S., King Sarah R. B., Kluz Tomasz, Knox Paul, Kobayashi Tatsuya, Koch Karl-Wilhelm, Kohonen-Corish Maija R. J., Kong Xiangpeng, Konkle-Parker Deborah, Korpela Kalevi M., Kostrikis Leondios G., Kraiczy Peter, Kratz Harald, Krause Gunter, Krebsbach Paul H., Kristensen Soren R., Kumari Prerna, Kunimatsu Akira, Kurdak Hatice, Kwon Young D., Lachat Carl, Lagisz Malgorzata, Laky Brenda, Lammerding Jan, Lange Matthias, Larrosa Mar, Laslett Andrew L., LeClair Elizabeth E., Lee Kyung-Woo, Lee Ming-Yih, Lee Moon-Soo, Li Genyuan, Li Jiansheng, Lieb Klaus, Lim Yau Y., Lindsey Merry L., Line Paul-Dag, Liu Dengcai, Liu Fengbin, Liu Haiyan, Liu Hongde, Lloyd Vett K., Lo Te-Wen, Locci Emanuela, Loidl Josef, Lorenzen Johan, Lorkowski Stefan, Lovell Nigel H., Lu Hua, Lu Wei, Lu Zhiyong, Luengo Gustavo S., Lundh Lars-Gunnar, Lysy Philippe A., Mabb Angela, Mack Heather G., Mackey David A., Mahdavi S. R., Maher Pamela, Maher Toby, Maity Sankar N., Malgrange Brigitte, Mamoulakis Charalampos, Mangoni Arduino A., Manke Thomas, Manstead Antony S. R., Mantalaris Athanasios, Marsal Jan, Marschall Hanns-Ulrich, Martin Francis L., Martinez-Raga Jose, Martinez-Salas Encarnacion, Mathieu Daniel, Matsui Yoichi, Maza Elie, McCutcheon James E., Mckay Gareth J., McMillan Brian, McMillan Nigel, Meads Catherine, Medina Loreta, Merrick B. Alex, Metzger Dennis W., Meunier Frederic A., Michaelis Martin, Micheau Olivier, Mihara Hisaaki, Mintz Eric M., Mizukami Takuo, Moalic Yann, Mohapatra D. P., Monteiro Antonia, Montes Matthieu, Moran John V., Morozov Sergey Y., Mort Matthew, Murai Noriyuki, Murphy Denis J., Murphy Susan K., Murray Shauna A., Naganawa Shinji, Nammi Srinivas, Nasios Grigorios, Natoli Roman M., Nguyen Frederique, Nicol Christine, van Nieuwerburgh Filip, Nilsen Erlend B., Nobile Clarissa J., O'Mahony Margaret, Ohlsson Sophie, Olatunbosun Oluremi, Olofsson Per, Ortiz Alberto, Ostrikov Kostya, Otto Siegmar, Outeiro Tiago F., Ouyang Songying, Paganoni Sabrina, Page Andrew, Palm Christoph, Paradies Yin, Parsons Michael H., Parsons Nick, Pascal Pigny, Paul Elisabeth, Peckham Michelle, Pedemonte Nicoletta, Pellizzon Michael A., Petrelli M., Pichugin Alexander, Pinto Carlos J. C., Plevris John N., Pollesello Piero, Polz Martin, Ponti Giovanna, Porcelli Piero, Prince Martin, Quinn Gwendolyn P., Quinn Terence J., Ramula Satu, Rappsilber Juri, Rehfeldt Florian, Reiling Jan H., Remacle Claire, Rezaei Mohsen, Riddick Eric W., Ritter Uwe, Roach Neil W., Roberts David D., Robles Guillermo, Rodrigues Tiago, Rodriguez Cesar, Roislien Jo, Roobol Monique J., Rowe J. Alexandra, Ruepp Andreas, van Ruitenbeek Jan, Rust Petra, Saad Sonia, Sack George H., Santos Manuela, Saudemont Aurore, Sava Gianni, Schrading Simone, Schramm Alexander, Schreiber Martin, Schuler Sidney, Schymkowitz Joost, Sczyrba Alexander, Seib Kate L., Shi Han-Ping, Shimada Tomohiro, Shin Jeon-Soo, Shortt Colette, Silveyra Patricia, Skinner Debra, Small Ian, Smeets Paul A. M., So Po-Wah, Solano Francisco, Sonenshine Daniel E., Song Jiangning, Southall Tony, Speakman John R., Srinivasan Mandyam V., Stabile Laura P., Stasiak Andrzej, Steadman Kathryn J., Stein Nils, Stephens Andrew W., Stewart Douglas I., Stine Keith, Storlazzi Curt, Stoynova Nataliya V., Strzalka Wojciech, Suarez Oscar M., Sultana Taranum, Sumant Anirudha V., Summers Mathew J., Sun Gang, Tacon Paul, Tanaka Kozo, Tang Haixu, Tanino Yoshinori, Targett-Adams Paul, Tayebi Mourad, Tayyem Reema, Tebbe Christoph C., Telfer Evelyn E., Tempel Wolfram, Teodorczyk-Injeyan Julita A., Thijs Gert, Thorne Sally, Thrift Amanda G., Tiffon Celine, Tinnefeld Philip, Tjahjono Daryono H., Tolle Fabrice, Toth Ervin, del Tredici Andria L., Tsapas Apostolos, Tsirigotis Konstantinos, Turak Ayse, Tzotzos George, Udo Edet E., Utsumi Toshiaki, Vaidyanathan Subramanian, Vaillant Michel, Valsesia Armand, Vandenbroucke Roosmarijn E., Veiga Feliciano H., Vendrell Marc, Vesk Peter A., Vickers Paul, Victor Victor M., Villemur Richard, Vohl Marie-Claude, Voolstra Christian R., Vuillemin Anne, Wakelin Steven, Waldron Levi, Walsh Laurence J., Wang Amanda Y., Wang Fuan, Wang Yun, Watanabe Yoichi, Weigert Andreas, Wen Jet-Chau, Wham Carol, White Ethan P., Wiener Jan, Wilharm Gottfried, Wilkinson Simon, Willmann Raffaella, Wilson Coralie, Wirth Brunhilde, Wojan Timothy R., Wolff Mathieu, Wong Bryan M., Wu Tzu-Wei, Wuerbel Hanno, Xiao Xiangshu, Xu Dong, Xu J. W., Xu Jianping, Xue Bin, Yalcin Suayib, Yan Hong, Yang En-Cheng, Yang Shiqi, Yang Wei, Ye Yuzhen, Ye Zhi-Qiang, Yli-Kauhaluoma Jari, Yoneyama Hiroshi, Yu Ying, Yuan Guo-Cheng, Yuh Chiou-Hwa, Zaccolo Manuela, Zeng Chen, Zevnik Branko, Zhang Chi, Zhang Li, Zhang Li, Zhang Yingkai, Zhang Yusen, Zhang Zhiyong, Zhang Zhong-Yin, Zhao Yuan, Zhou Min, Zuberbier Torsten, Aanei Carmen M., Ahmad Rafi, Al-Lawama Manar, Alanio Alexandre, Allardyce Judith, Alonso-Caneiro David, Atack John M., Baier Dirk, Bansal Abhisheka, Benezeth Yannick, Berbesque Colette, Berrevoet Frederik, Biedermann Peter H. W., Bijleveld Erik, Bittner Florian, Blombach Fabian, Van den Bos Wouter, Boudreau Shellie A., Bramoweth Adam D., Braubach Oliver, Cai Yufeng, Campbell Matthew, Cao Zanxia, Catry Thibault, Chen Xin, Cheng Shuiqin, Chung Hee-Jung, Chavez-Fumagalli Miguel A., Conway Aaron, Costa Bruno M., Cyr Normand, Dean Lorraine T., Denzel Martin S., Dlamini S. V., Dudley Kevin J., Dufies Maeva, Ecke Thorsten, Eckweiler Denitsa, Eixarch Elisenda, El-Adawy Hosny, Emmrich Julius V., Eustace Alex J., Falter-Wagner Christine M., Fuss Johannes, Gao Jianzhao, Gill Martin R., Gloyn Liz, Goggs Robert, Govinden Usha, Greene Garrett, Greiff Victor, Grundle D. S., Gruneberg Patrick, Gumede Nicksy, Haore Gbaguidi, Harrison Pille, Hoenner Xavier, Hojsgaard Diego, Hori Hikaru, Ikonomopoulou Maria P., Jeurissen Patrick, Johnson Daniel M., Kabra Dhiraj, Kamagata Koji, Karmakar Chandan, Kasian Olga, Kaye Linda K., Khan Murad M., Kim Yong-Min, Kish J. K., Kobold Sebastian, Kohanbash Gary, Kohls Gregor, Kugler Jan-Michael, Kumar Gyanendra, Lacy-Colson Jon, Latif Asam, Lauschke Volker M., Li Bingling, Lim Chinten J., Liu Fang, Liu Xiaodong, Lu Jin-Jian, Lu Qiang, Mahavadi Poornima, Marzocchi Ugo, McGarrigle Christine A., van Meerten Tom, Min Rogier, Moal Iain, Molari Massimiliano, Molleman Lucas, Mondal Saiful R., Van de Mortel Thea, Moss W. N., Moultos Othonas A., Mukherjee Maheswari, Nakayama Kazuhiko, Narayan Edward, Navaratnarajah, Neumann Philipp-Alexander, Nie Jiyun, Nie Yingjiu, Niemeyer Frank, Fiona, Nwaiwu Ogueri, Oldenmenger Wendy H., Olumayede Emmanuel, Ou Jianhong, Pallebage-Gamarallage Menuka, Pearce Simon P., Pelkonen Tuula, Pelleri Maria C., Pereira Joana L., Pheko Mpho, Pinto Karina A., Piovesan Allison, Pluess Michael, Podolsky Illya M., Prescott Julie, Qi Dongchen, Qi Xingshun, Raikou Vaia D., Ranft Andreas, Rhodes Johanna, Rotge Jean-Yves, Rowe Anna D., Saggar Manish, Schuon Robert A., Shahid Shaouli, Shalchyan Vahid, Shirvalkar Prasad, Shiryayev Oleg, Singh Jugpreet, Smout Michael J., Soares Antonio, Song Chunjiao, Srivastava Kshitij, Srivastava Rupesh K., Sun Jim, Szabo Attila, Szymanski Wiktor, Tai Chan N. P., Takeuchi Hisashi, Tanadini-Lang S., Tang Fei, Tao Wanyin, Theron G., Tian Chang F., Tian Yu-Shi, Tuttle Lisa M., Valenti Anna, Verlot Pierre, Walker Mirella, Wang Jun, Welter Danielle, Winslade Matthew, Wu Dalei, Wu Yi-Rui, Xiao Han, Xu Beisi, Xu Juan, Xu Ziyue, Yang Dongdong, Yang Mingjun, Yankilevich Patricio, You Yuyi, Yu Chenglong, Zhan Jian, Zhang Gong, Zhang Kai, Zhang Tuo, Zhang Yi, Zhao Guoyan, Zhao Jing, Zhou Xiaofan, Zhu Zhenxing, Ajani Penelope A., Anazodo Udunna C., Bagloee Saeed A., Bail Kasia, Bar Ido, Bathelt Joe, Benkeser David, Bernier Meghan L., Blanchard Adam M., Boakye Dominic W., Bonatsos Vasileios, Boon Michele H., Bouboulis George, Bromfield Elizabeth, Brown Joshua, Bul Kim C. M., Burton Kathryn J., Butkowski Eugene G., Carroll Grace, Chao Fengqing, Charrier Elisabeth E., Chen Xiaoyin, Chen Yu-Chih, Chenguang, Choi Jane R., Christoffersen Tore, Comel Joao C., Cosse Cyril, Cui Yanru, van Dessel Pieter, Dhaval, Diodato Daria, Duffey Maelle, Dutt Avik, Egea Luis G., El-Said Mohammed, Faye Martin, Fernandez-Fernandez Beatriz, Foley Kieran G., Founou Luria L., Fu Fan, Gadelkareem Rabea A., Galimov Evgeny, Garip Gulcan, Gemmill Alison, Gouil Quentin, Grey James, Gridneva Zoya, Grothe Michel J., Grebert Theophile, Guerrero Fabricio, Guignard Leo, Haenssgen Marco J., Hasler David, Holgate Joan Y., Huang Ancheng, Hulse-Kemp Amanda M., Jean-Quartier Claire, Jeon Sang-Min, Jia Yangyang, Jutzeler Catherine, Kalatzis Panagiotis, Karim Masud, Karsay Kathrin, Keitel Anne, Kempe Andreas, Keown Jeremy R., Khoo Chin M., Khwaja Nyil, Kievit Rogier A., Kosanic Aleksandra, Koutoukidis Dimitrios A., Kramer Paul, Kumar Dilip, Kirag Nukhet, Lanza Giuseppe, Le Thuc D., Leem Jung W., Leightley Daniel, Leite Andreia, Lercher Lukas, Li Ying, Lim Renly, Lima Luiz R. A., Lin Li, Ling Tong, Liu Yuchen, Liu Zhonghua, Lu Yao, Lum Fok M., Luo Hang, Machhi Jatin, Macleod Angus, Macwan Isaac, Madala Hanumantha R., Madani Nima, de Maio Nicola, Makowiecki Kalina, Mallinson Daniel J., Margelyte Ruta, Maria Caracausi, Markonis Y., Marsili Luca, Mavoa Suzanne, McWilliams Lorna, Megersa Moa, Mendes Caetano S. M., Menichetti Julia, Mercieca-Bebber Rebecca, Miller Jack J., Minde David-Paul M., Minges Alexander, Mishra Eleanor, Mishra Virendra R., Moores Carly, Morrice Nicola, Moskalensky Alexander E., Navarin Nicolo, Negera Edessa, Nolet Philippe, Nordberg Ana, Norden Rickard, Nowicki Jessica P., Olova Nelly, Olszewski Pawel, Onzima Robert, Pan Chih-Long, Park Charny, Park Dong Ik, Park Seyoung, Patil Chandrashekhar D., Pedro Sansoa A., Perry Samuel R., Peter Jessica, Peterson Brent M., Pezzuolo Andrea, Pozdnyakov Ilya, Qian Siyu, Qin Lei, Rafe Ali, Raote Ishier, Raza Ali, Rebl Henrike, Refai Osama, Regan Tim, Richa Tambi, Richardson Mark F., Robinson K. R., Rossoni Luca, Rouet Romain, Safaei Soroush, Schneeberger Pierre H. H., Schwotzer Daniela, Sebastian Agata, Selinski Jennifer, Seltmann Stefanie, Sha Feng, Shalev Nir, Shang Jin-Long, Singer Josef, Singh Mandeep, Smith Taylor, Solomon-Moore Emma, Song Lijuan, Soraggi Samuele, Stanley Ryan, Steckhan Nico, Strobl Frederic, Subissi Lorenzo, Supriyanto Irwan, Surve Chinmay R., Suzuki Tomo, Syme Caitlin, Sorelius Karl, Tang Young, Tantawy Marwa, Tennakoon Sumudu, Teseo Serafino, Toelzer Christine, Tomov Nikola, Tovar Miguel, Tran Linh, Tripathi Sushil, Tuladhar Anil M., Ukubuiwe Azubuike C., Ung Carolina O. L., Valgepea Kaspar, Vatanparast Hamid, Vidal Arnau, Wang Fang, Wang Qing, Watari Ricky, Webster Rebecca, Webster Ruth, Wei Junnian, Wibowo David, Wingenbach Tanja S. H., Xavier Rose M., Xiao Shumin, Xiong Peng, Xu Shicai, Xu Shilin, Yao Ruifeng, Yao Wen, Yin Qinan, Yu Yongbo, Zaitsu Masayoshi, Zeineb Zian, Zhan Xiao-Yong, Zhang Jilei, Zhang Rongqiang, Zhang Wei, Zhang Xianglilan, Zheng Shan, Zhou Bailing, Zhou Xiaoyan, Ahmad Haroon, Akinwumi Sayo A., Albery Gregory F., Alhowimel Ahmed, Ali Junaid, Alshehri Mansour, Alsuhaibani Mohammed, Anikin Andrey, Azubuike Samuel O., Bach-Mortensen Anders, Baltiansky Lior, Bartas Martin, Belachew Kiflemariam Y., Bhardwaj Vivek, Binder Karin, Bland Nicholas S., Boah Michael, Bullen Benjamin, Calabro Giovanna E., Callahan Tiffany J., Cao Bing, Chalmers Kelsey, Chang Wei, Che Zhengping, Chen Andrew T. Y., Chen Haimin, Chen Huaming, Chen Youning, Chen Zhao, Choi YoungRok, Chowdhury Mohiuddin A. K., Christensen Martin R., Cooke Robert S. C., Cottini Marzia, Covington Natalie V., Cunningham Catriona, Delarocque Julien, Devos Lucie, Dhar Aurup R., Ding Ke-Feng, Dong Kexian, Dong Zheng, Dreyer Niklas, Ekstrand Chelsea, Fardet Tanguy, Feleke Berhanu E., Feurer Thomas, Freitas Angela, Gao Tian, Asefa N. G., Giganti Francesco, Grabowski Piotr, Guerra-Mora Jose R., Guo Chengying, Guo Xinyi, Gupta Himanshu, He Shuonan, Heijne Marloes, Heinemann Stephanie, Hogrebe Alexander, Huang Zhengping, Iskander-Rizk Sophinese, Iyer Lavanya M., Jahan Yasmin, James Ameh S., Joel Emmanuel, Joffroy Bastian, Jegousse Clara, Kambondo George, Karnati Priyanka, Kaya Cihan, Ke An, Kelly Daniel, Kickert Rob, Kidibule Peter E., Kieselmann Jennifer P., Kim Hyeon J., Kitazawa Takeshi, Lamberts Aniek, Li You, Liang Huakang, Linn Sabrina N., Litfin Thomas, Liusuo Wang, Lygirou Vasiliki, Mahato Ajay K., Mai Zhi-Ming, Major Rupert W., Mali Samira, Mallis Panagiotis, Mao Wenzhi, Mao Wenzhi, Marvin-Dowle Katie, Marvin-Dowle Katie, Mason Leanda D., Merideth Ben, Merino-Plaza Maria J., Merlaen Britt, Messina Rossella, Mishra Anand K., Muhammad Junaid, Musinguzi Conrad, Nanou Afroditi, Naqash Amreen, Nguyen Joe T., Nguyen Thi T. H., Ni Duan, Nida, Notcovich Shirli, Ohst Barnabas, Ollivier Quinn R., Osses Daniel F., Peng Xiangda, Plantinga Arnoud, Pulia Michael, Rafiq Muhammad, Raman Ayush, Raucher-Chene Delphine, Rawski Rafal, Ray Asit, Razak Lubna A., Rudolf Kevin, Rusch Peter, Sadoine Margaux L., Schmidt Axel, Schurr Roey, Searles Stephen, Sharma Saurab, Sheehan Barry, Shi Chunhu, Shohayeb Belal, Sommerlad Andrew, Strehlow Jan, Sun Xianbao, Sundar Raghav, Taherzadeh Ghazaleh, Tahir Nur D. M., Tang Jun, Testa Jean, Tian Zhiqi, Tingting Qian, Verheijen Geert P., Vickstrom Casey, Wang Teng, Wang Xiaomin, Wang Zhenxing, Wei Pan, Wilson Alex, Wyart, Yassine Abdul-Amir, Yousefzadeh Abbas, Zare Asma, Zeng Zhen, Zhang Chengrong, Zhang Haowen, Zhang Linxing, Zhang Tongchuan, Zhang Weijia, Zhang Zhe, Zhou Jianyu, Zhu Dongjie, Adamo Vincenzo, Adeyemo Adebolajo A., Aggelidou Maria, Al-Owaifeer Adi M., Al-Riyami Arwa Z., Alzghari Saeed K., Andersen Vibeke, Angus Kathryn, Asaduzzaman Muhammad, Asady Hadi, Ato Dai, Bai Xiaoyong, Baines Rebecca L., Ballantyne Maghan, Ban Bo, Beck Jill, Ben-Nafa Walid, Black Emma, Blancher Antoine, Blankstein Ron, Bodagh Neil, Borges Paulo A. V., Brooks Anastasia, Brox-Ponce Josue, Brunetti Arturo, Canham Colin D., Carninci Piero, Carvajal Richard, Chang Shun C., Chao Jie, Chatterjee Pranab, Chen He, Chen Yi-Chun, Chhatriwalla Adnan K., Chikowe Ibrahim, Chuang Trees-Juen, Collevatti Rosane G., Valera-Cornejo Diego A., Cuenda Ana, Dao Myriam, Dauga Delphine, Deng Zaian, Devkota Kiran, Doan Lisa V., Elewa Yaser H. A., Fan Dongsheng, Faruk Mohammed, Feifei Shi, Ferguson Trevor S., Fleres Francesco, Foster Emma J., Foster C. Stephen, Furer Tzvi, Gao Yibo, Garcia-Rivera Enid J., Gazdar Adi, George Ronald B., Ghosh Sayantan, Gianchecchi Elena, Gleason Joshua M., Hackshaw Allan, Hall Adam, Hall Richard, Harper Paul, Hogg William E., Huang Guangqun, Hunter Kylie E., IJzerman Adriaan P., Jesus Carlos, Jian Gao, Lewis James S. Jr., Kanj Souha S., Kaur Harsheen, Kelly Shona, Kheir Fayez, Kichatova V. S., Kiyani Musa, Klein Reinhild, Kovesi Tom, Kraschnewski Jennifer L., Kumar Addanki P., Labutin Dmitry, Lazo-Langner Alejandro, Leclercq Guy, Li Maoteng, Li Qingchun, Li Tangliang, Li Yongzhe, Liao Wei-Ting, Liao Zheng-yin, Lin Jessica, Lizer J., Lobreglio Giambattista, Lowies Cher, Lu Cheng, Majeed Haroon, Martin Adam, Martinez-Sobrido Luis, Meresh Edwin, Middelveen Marianne, Mohebbi Alireza, Mota Jorge, Mozaheb Zahra, Muyaya Ley, Nandhakumar Amar, Ng Sheryl H. X., Obeidat Monther, Oh Deog-Hwan, Owais Mohammed, Pace-Asciak Pia, Panwar Ajay, Park Caroline, Patterson Chris, Penagos-Tabaree Felipe, Pianosi Paolo T., Pinzi Valentina, Pridans Clare, Psaroulaki Anna, Pujala Ravi Kumar, Pulido-Arjona Leonardo, Qi Peng-Fei, Rahman Proton, Rai Nayanjot K., Rassaf Tienush, Refardt Julie, Ricciardi Walter, Riess Olaf, Rovas Alexandros, Sacks Frank M., Saleh Sherif, Sampson Christopher, Schmutz Axel, Sepanski Robert, Sharma Neeraj, Singh Manisha, Spearman Paul, Subramaniapillai Mehala, Swali Ritu, Tan Cher M., Tellechea Juan I., Thomas Lisa-Marie, Tong Xin, Veys Ralf, Vitriol Veronica, Wang Horng-Dar, Wang Jinhui, Wang Jiucun, Waugh Jason, Webb S. A., Williams Brendan A., Workman Alan D., Xiang Tingxiu, Xie Li-Xin, Xu Jun, Xu Taosheng, Yang Chongjun, Yoon Jihoon G., Yuan Christina M., Zaritsky Arno, Zhang Yao, Zhao Haochen, Zuckerman Hannah, Lyu Ran, Pullan Wayne, Zhou Yaoqi

    DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION     2019.10

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    DOI: 10.1093/database/baz085

    Web of Science

  21. Does I-131 uptake in the subhyoid portion or lymph nodes affect the outcome of low-dose ablation therapy for patients with differentiated thyroid cancer?

    Ito S., Iwano S., Kato K., Naganawa S.

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   Vol. 46 ( SUPPL 1 ) page: S662 - S663   2019.10

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    Web of Science

  22. High-dose-rate intracavitary brachytherapy for recurrent cervical cancer in the vaginal stump after hysterectomy.

    Yuka Kozai, Yoshiyuki Itoh, Mariko Kawamura, Rie Nakahara, Junji Ito, Tohru Okada, Fumitaka Kikkawa, Mitsuru Ikeda, Shinji Naganawa

    Nagoya journal of medical science   Vol. 81 ( 3 ) page: 351 - 358   2019.8

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    This study aimed to evaluate the treatment outcomes of patients who received high-dose-rate intracavitary brachytherapy (HDR-BT) using Iridium-192 with or without external beam radiotherapy as definitive treatment for recurrent cervical cancer after hysterectomy. Thirty-six patients with local recurrence after hysterectomy received radiotherapy including HDR-BT from 2005 to 2013. Overall survival, local control rate, and progression-free survival were estimated retrospectively via the Kaplan-Meier method. Late adverse events were also scored using the Common Terminology Criteria for Adverse Events (version 3.0). Median follow-up time was 38 (range, 7.4-101.3) months. The 3-year estimates of overall survival, local control rate, and progression-free survival were 100.0%, 82.8%, and 76.8%, respectively. Two patients (5.6%) had grade 2 lymphedema, but no other adverse events greater than grade 2 were reported. In conclusion, HDR-BT was an effective treatment modality for patients with cervical cancer recurrence in the vaginal stump.

    DOI: 10.18999/nagjms.81.3.351

    Web of Science

    PubMed

  23. Development of Three-Dimensional Printed Compensator for Improvement of Dose Distribution in Boron Neutron Capture Therapy: A Preliminary Study

    Kamomae T., Sakurai Y., Oita M., Takata T., Niimi T., Matsumura T., Saito T., Komada T., Kato K., Itoh Y., Naganawa S.

    MEDICAL PHYSICS   Vol. 46 ( 6 ) page: E411 - E411   2019.6

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  24. Evaluation of Ra-223 therapy on bone metastases of prostate cancer by F-18-fluoride PET/CT, F-18-FDG PET/CT and bone scintigraphy/SPECT

    Kato Katsuhiko, Odagawa Tetsuro, Fujita Naotoshi, Tsutsumi Yoshinori, Abe Shinji, Yamamoto Seiichi, Naganawa Shinji

    JOURNAL OF NUCLEAR MEDICINE   Vol. 60   page: .   2019.5

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  25. Influence of implanted metals in new CT reconstruction algorithm for radiotherapy treatment planning

    Kamomae T., Nakaya T., Kawabata F., Okudaira K., Kumagai M., Oguchi H., Itoh Y., Naganawa S.

    RADIOTHERAPY AND ONCOLOGY   Vol. 133   page: S1132 - S1132   2019.4

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  26. Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy. International journal

    Kazuhiro Hara, Hirohisa Watanabe, Epifanio Bagarinao, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Takashi Tsuboi, Mizuki Ito, Naoki Atsuta, Hisayoshi Niwa, Toshiaki Taoka, Satoshi Maesawa, Shinji Naganawa, Masahisa Katsuno, Gen Sobue

    Journal of neurology   Vol. 265 ( 9 ) page: 2079 - 2087   2018.9

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    OBJECTIVE: We examined the anatomical involvement related to cognitive impairment in patients with multiple system atrophy (MSA). METHODS: We examined 30 patients with probable MSA and 15 healthy controls. All MSA patients were assessed by the Unified MSA-Rating scale and Addenbrooke's Cognitive Examination-Revised (ACE-R). We classified 15 MSA patients with ACE-R scores > 88 as having normal cognition (MSA-NC) and 15 with scores ≤ 88 as having cognitive impairment (MSA-CI). All subjects underwent 3 T MRI scanning and were investigated using voxel-based morphometry and diffusion tensor imaging. RESULTS: Both the MSA-NC and MSA-CI patients exhibited cerebellar but not cerebral atrophy in voxel-based morphometry compared to controls. In contrast, tract-based spatial statistics revealed widespread and significantly decreased fractional anisotropy (FA) values, as well as increased mean diffusivity, radial diffusivity, and axial diffusivity in both the cerebrum and cerebellum in MSA-CI patients compared to controls. MSA-NC patients also exhibited similar involvement of the cerebellum but less extensive involvement of the cerebrum compared with the MSA-CI patients. In particular, FA values in MSA-CI patients were significantly decreased in the anterior part of the left corpus callosum compared with those in MSA-NC patients. The mean FA values in the left anterior part of the corpus callosum were significantly correlated with total ACE-R scores and subscores (memory, fluency, and language) in MSA patients. CONCLUSIONS: Decreased FA values in the anterior corpus callosum showed a significant correlation with cognitive impairment in MSA.

    DOI: 10.1007/s00415-018-8923-7

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  27. Impact of the Glymphatic System on the Kinetic and Distribution of Gadodiamide in the Rat Brain: Observations by Dynamic MRI and Effect of Circadian Rhythm on Tissue Gadolinium Concentrations. International journal

    Toshiaki Taoka, Gregor Jost, Thomas Frenzel, Shinji Naganawa, Hubertus Pietsch

    Investigative radiology   Vol. 53 ( 9 ) page: 529 - 534   2018.9

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    OBJECTIVES: The glymphatic system is a recently hypothesized waste clearance system of the brain in which perivascular space constitutes a pathway similar to the lymphatic system in other body regions. Sleep and anesthesia are reported to influence the activity of the glymphatic system. Because rats are nocturnal animals, the glymphatic system is expected to be more active during the day. We attempted to elucidate the influence of the glymphatic system for intravenously injected gadodiamide in the rat brain by 2 experiments. One was a magnetic resonance imaging (MRI) experiment to evaluate the short-term dynamics of signal intensity changes after gadodiamide administration. The other was a quantification experiment to evaluate the concentration of retained gadolinium within the rat brain after repeated intravenous administration of gadodiamide at different times of day and levels of anesthesia. MATERIALS AND METHODS: The imaging experiment was performed on 6 rats that received an intravenous injection of gadodiamide (1 mmol/kg) and dynamic MRI for 3 hours at 2.4-minute intervals. The time course of the signal intensity changes was evaluated for different brain structures. The tissue quantification experiment was performed on 24 rats divided into 4 groups by injection time (morning, late afternoon) and anesthesia (none, short, long) during administration. All animals received gadodiamide (1.8 mmol/kg, 8 times over 2 weeks). Gadolinium concentration of dissected brain tissues was quantified 5 weeks after the last administration by inductively coupled plasma mass spectrometry. RESULTS: In the imaging experiment, muscle and the fourth ventricle showed an instantaneous signal intensity increase immediately after gadodiamide injection. The signal curve of the cerebral cortex and deep cerebellar nuclei reached the peak signal intensity later than the fourth ventricle but earlier than that of the prepontine cistern. In the gadolinium quantification experiment, the concentration in the group with the morning injection showed a significantly lower concentration than the late afternoon injection group. The lowest tissue gadolinium concentrations were found in the groups injected in the morning during long anesthesia. CONCLUSIONS: Instantaneous transition of gadodiamide from blood to cerebrospinal fluid was indicated by dynamic MRI. The gadodiamide distribution to the cerebral cortex and deep cerebellar nuclei seemed to depend on both blood flow and cerebrospinal fluid. This confirms previous studies indicating that the cerebrospinal fluid is one potential pathway of gadolinium-based contrast agent entry into the brain. For the distribution and clearance of the gadodiamide from brain tissue, involvement of the glymphatic system seemed to be indicated in terms of the influence of sleep and anesthesia.

    DOI: 10.1097/RLI.0000000000000473

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  28. Myocardial motion analysis based on an optical flow method using tagged MR images.

    Daiki Tabata, Haruo Isoda, Kaori Kato, Hiroki Matsubara, Takafumi Kosugi, Takashi Kosugi, Masaki Terada, Atsushi Fukuyama, Yoshiaki Komori, Shinji Naganawa

    Radiological physics and technology   Vol. 11 ( 2 ) page: 202 - 211   2018.6

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    We developed a method of velocimetry based on an optical flow method using quantitative analyses of tagged magnetic resonance (MR) images (tagged MR-optical flow velocimetry, tMR-O velocimetry). The purpose of our study was to examine the accuracy of measurement of the proposed tMR-O velocimetry. We performed retrospective pseudo-electrocardiogram (ECG) gating tagged cine MR imaging on a rotating phantom. We optimized imaging parameters for tagged MR imaging, and validated the accuracy of tMR-O velocimetry. Our results indicated that the difference between the reference velocities and the computed velocities measured using optimal imaging parameters was less than 1%. In addition, we performed tMR-O velocimetry and echocardiography on 10 healthy volunteers, for four sections of the heart (apical, midventricular, and basal sections aligned with the short-axis, and a four-chamber section aligned with the long-axis), and obtained radial and longitudinal myocardial velocities in these sections. We compared the myocardial velocities obtained using tMR-O velocimetry with those obtained using echocardiography. Our results showed good agreement between tMR-O velocimetry and echocardiography in the radial myocardial velocities in three short-axial sections and longitudinal myocardial velocities on the midventricular portion of the four-chamber section in the long-axis. In the study conducted on the rotating phantom, tMR-O velocimetry showed high accuracy; moreover, in the healthy volunteers, the myocardial velocities obtained using tMR-O velocimetry were relatively similar to those obtained using echocardiography. In conclusion, tMR-O velocimetry is a potentially feasible method for analyzing myocardial motion in the human heart.

    DOI: 10.1007/s12194-018-0456-3

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  29. Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio.

    Toshio Ohashi, Shinji Naganawa, Toshio Katagiri, Kayao Kuno

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 17 ( 1 ) page: 67 - 72   2018.1

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    PURPOSE: We routinely obtain the endolymphatic hydrops (EH) image using heavily T2-weighted three dimensional-fluid attenuated inversion recovery (hT2w-3D-FLAIR) imaging at 4 hours after intravenous administration of a single-dose of gadolinium-based contrast media (IV-SD-GBCM). While repeating the examination, we speculated that the contrast enhancement of the perivascular space (PVS) in the basal ganglia might be related to the degree of EH. Therefore, the purpose of this study was to investigate the relationship between the endolymphatic volume ratio (%ELvolume) and the signal intensity of the PVS (SI-PVS). MATERIALS AND METHODS: In 20 patients with a suspicion of EH, a heavily T2-weighted 3D-turbo spin echo sequence for MR cisternography (MRC) and an hT2w-3D-FLAIR as a positive perilymph image (PPI) were obtained at 4 hours after IV-SD-GBCM. The %ELvolume of the cochlea and the vestibule were measured on the previously reported HYDROPS2-Mi2 image. The PVS in the basal ganglia was segmented on MRC using a region-growing method. The PVS regions were copied and pasted onto the PPI, and the SI-PVS was measured. The larger value of the right and the left ears was employed as the %ELvolume, and the weighted average of both sides was employed as the SI-PVS. The correlation between the %ELvolume and the SI-PVS was evaluated. RESULT: There was a strong negative linear correlation between the %ELvolume of the cochlea and the SI-PVS (r = -0.743, P < 0.001); however, there was no significant correlation between the %ELvolume of the vestibule and the SI-PVS (r = -0.267, P = 0.256). CONCLUSION: There was a strong negative correlation between the cochlear %ELvolume and the SI-PVS. Contrast enhancement of PVS might be a biomarker of EH.

    DOI: 10.2463/mrms.mp.2017-0001

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  30. FDG PET/CT Overcomes Discordance Between Clinical and Pathologic TNM Classification of Small-size Primary Lung Cancer: Influence on Postoperative Prognosis. International journal

    Hiroyasu Umakoshi, Shingo Iwano, Kohei Yokoi, Shinji Ito, Rintaro Ito, Koji Kawaguchi, Takayuki Fukui, Shinji Naganawa

    Clinical lung cancer   Vol. 19 ( 1 ) page: e37 - e45   2018.1

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    INTRODUCTION: We aimed to determine the concordance between the clinical stage (c-stage) and pathologic stage (p-stage) for patients with small-size lung cancer. Additionally we searched for prognostic factors other than the TNM stage. PATIENTS AND METHODS: We retrospectively reviewed the preoperative multidetector computed tomography (CT) and positron emission tomography/CT reports, surgical records, and pathologic reports of patients with primary lung cancer ≤ 3 cm. The Union for International Cancer Control TNM seventh edition classification of c-stage and p-stage were compared. The tumors were classified into multiple subgroups by concordance or discordance between the c-stage and p-stage. Disease-free survival (DFS) was assessed using survival analysis to assess the tumor characteristics that were predictive of prognosis. RESULTS: A total of 289 surgically resected primary lung cancers were evaluated. The concordance between c-stage and p-stage was 65.4%, with moderate reproducibility (kappa coefficient, 0.467). The upstaging rate from c-stage I to p-stage II-IV was 9.4%, and these patients had significantly worse DFS than those with a concordant stage I classification (P < .001). The main reason for upstaging was an underestimation of metastases to the hilar lymph nodes (n = 7) or mediastinal lymph nodes (n = 11). A multivariate Cox proportional hazards model showed that the significant predictive factors for DFS were p-stage (hazard ratio, 1.342; P = .003) and maximum standardized uptake value on positron emission tomography/CT (hazard ratio, 12.162; P = .001). CONCLUSION: The concordance rate between c-stage and p-stage for small primary lung cancers had moderate reproducibility. Discordance between c-stage I and p-stage II-IV significantly affected DFS. The maximum standardized uptake value of the primary lesion was an independent prognostic factor, and combining it with c-stage might improve the prediction of therapeutic outcomes.

    DOI: 10.1016/j.cllc.2017.05.021

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  31. Effects of Gradient Coil Noise and Gradient Coil Replacement on the Reproducibility of Resting State Networks. International journal

    Epifanio Bagarinao, Erina Tsuzuki, Yukina Yoshida, Yohei Ozawa, Maki Kuzuya, Takashi Otani, Shuji Koyama, Haruo Isoda, Hirohisa Watanabe, Satoshi Maesawa, Shinji Naganawa, Gen Sobue

    Frontiers in human neuroscience   Vol. 12   page: 148 - 148   2018

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    The stability of the MRI scanner throughout a given study is critical in minimizing hardware-induced variability in the acquired imaging data set. However, MRI scanners do malfunction at times, which could generate image artifacts and would require the replacement of a major component such as its gradient coil. In this article, we examined the effect of low intensity, randomly occurring hardware-related noise due to a faulty gradient coil on brain morphometric measures derived from T1-weighted images and resting state networks (RSNs) constructed from resting state functional MRI. We also introduced a method to detect and minimize the effect of the noise associated with a faulty gradient coil. Finally, we assessed the reproducibility of these morphometric measures and RSNs before and after gradient coil replacement. Our results showed that gradient coil noise, even at relatively low intensities, could introduce a large number of voxels exhibiting spurious significant connectivity changes in several RSNs. However, censoring the affected volumes during the analysis could minimize, if not completely eliminate, these spurious connectivity changes and could lead to reproducible RSNs even after gradient coil replacement.

    DOI: 10.3389/fnhum.2018.00148

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  32. The retention pattern of THK5351 pet imaging and functional network disruption associated with development of Alzheimer's disease

    Yokoi T, Watanabe H, Yamaguchi H, Bagarinao E, Masuda M, Imai K, Ogura A, Ohdake R, Kawabata K, Hara K, Riku Y, Ishigaki S, Katsuno M, Kato K, Naganawa S, Okamura N, Miyao S, Yanai K, Sobue G

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page: 960 - 961   2017.10

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    DOI: 10.1016/j.jns.2017.08.2705

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  33. Incidental findings on computed tomography for preoperative assessment before transcatheter aortic valve implantation in Japanese patients.

    Akihiro Tobe, Akihito Tanaka, Yoshiyuki Tokuda, Yusuke Miki, Kenji Furusawa, Sho Akita, Taro Fujii, Yoshinori Tsutsumi, Hideki Ishii, Shingo Iwano, Shinji Naganawa, Akihiko Usui, Toyoaki Murohara

    Heart and vessels   Vol. 36 ( 12 ) page: 1911 - 1922   2021.12

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    Extra-cardiovascular incidental findings (IFs) on preoperative computed tomography (CT) are frequently observed in transcatheter aortic valve implantation (TAVI) candidates. However, the backgrounds of TAVI candidates and comorbidities differ based on the race and/or country, and data on IFs in a specific population are not always applicable to another. The aim of this study was to assess the prevalence, type, and clinical impact of IFs in Japanese TAVI candidates. This was a retrospective, single-center, observational study. CT reports of 257 TAVI candidates were reviewed, and IFs were classified as (a) insignificant: findings that did not require further investigation, treatment, or follow-up; (b) intermediate: findings that needed to be followed up or were considered for further investigation but did not affect the planning of TAVI; and (c) significant: findings that required further investigation immediately or affected the planning of TAVI. At least one IF was found in 254 patients (98.8%). Insignificant, intermediate, and significant IFs were found in 253 (98.4%), 153 (59.5%), and 34 (13.2%) patients, respectively. Newly indicated significant IFs were found in 19 patients (7.4%). In 2 patients (0.8%), TAVI was canceled because of significant IFs. In patients who consequently underwent TAVI, the presence of significant IFs was not associated with the duration from CT performance to TAVI [28 (19-40) days vs. 27 (19-43) days, p = 0.74] and all-cause mortality during the median follow-up period of 413 (223-805) days (p = 0.44). Almost all Japanese TAVI candidates had at least one IF, and the prevalence of significant IFs was not negligible. Although the presence of significant IFs was not associated with mid-term mortality, appropriate management of IFs was considered important.

    DOI: 10.1007/s00380-021-01875-2

    PubMed

  34. "Speckled Enhancement" on Gd-EOB-DTPA Enhanced MR Imaging of Primary Hepatic Mucosa-associated Lymphoid Tissue Lymphoma.

    Ryota Hyodo, Yasuo Takehara, Ayumi Nishida, Masaya Matsushima, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021.10

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    PURPOSE: To elucidate MRI features of primary hepatic mucosa-associated lymphoid tissue (MALT) lymphoma, particularly, the "speckled enhancement" on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI. METHODS: The institutional review board approved this retrospective observational study and waived informed consent. Using our picture archiving and communication systems and electronic medical records, five patients histopathologically diagnosed as hepatic MALT lymphoma and clinically confirmed as primary lesions who had undergone dynamic contrast-enhanced (DCE)-CT and DCE-MRI with Gd-EOB-DTPA were identified from September 2009 to December 2020. Two radiologists assessed their CT and MRI data in consensus with a pathologist's advice. RESULTS: Overall, five lesions in five patients were included in this study. Precontrast CT showed hypoattenuation in all lesions. In the arterial phase of DCE-CT, four lesions (80%) showed hyperattenuation, whereas all lesions showed iso- to hypoattenuation in the delayed phase. A vessel penetration sign was also observed in all lesions. On MRI, all lesions showed hypointensity on T1-weighted images, hyperintensity on T2-weighted images, and restricted diffusion on diffusion-weighted images. Both DCE-CT and DCE-MRI with Gd-EOB-DTPA showed similar enhancement patterns, except for the hepatocyte phase. Notably, however, four out of five lesions showed characteristic "speckled enhancement" that refers to punctate positive enhancements within the low signal lesions on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI pathologically confirmed to be hepatocyte clusters that remained in the tumor. CONCLUSION: Primary hepatic MALT lymphomas were characterized by arterial phase enhancement, restricted diffusion, vessel penetration sign, and more specifically "speckled enhancement" in the hepatobiliary phase of DCE-MRI with Gd-EOB-DTPA.

    DOI: 10.2463/mrms.mp.2021-0069

    PubMed

  35. Magnetic resonance cisternography imaging findings related to the leakage of Gadolinium into the subarachnoid space

    Rei Nakamichi, Toshiaki Taoka, Hisashi Kawai, Tadao Yoshida, Michihiko Sone, Shinji Naganawa

    Japanese Journal of Radiology   Vol. 39 ( 10 ) page: 927 - 937   2021.10

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    <title>Abstract</title><sec>
    <title>Purpose</title>
    To identify magnetic resonance cisternography (MRC) imaging findings related to Gadolinium-based contrast agent (GBCA) leakage into the subarachnoid space.


    </sec><sec>
    <title>Materials and methods</title>
    The number of voxels of GBCA leakage (V-leak) on 3D-real inversion recovery images was measured in 56 patients scanned 4 h post-intravenous GBCA injection. Bridging veins (BVs) were identified on MRC. The numbers of BVs with surrounding cystic structures (BV-cyst), with arachnoid granulations protruding into the superior sagittal sinus (BV-AG-SSS) and the skull (BV-AG-skull), and including any of these factors (BV-incl) were recorded. Correlations between these variables and V-leak were examined based on the Spearman’s rank correlation coefficient. Receiver-operating characteristic (ROC) curves were generated to investigate the predictive performance of GBCA leakage.


    </sec><sec>
    <title>Results</title>
    V-leak and the number of BV-incl were strongly correlated (<italic>r</italic> = 0.609, <italic>p</italic> &lt; 0.0001). The numbers of BV-cyst and BV-AG-skull had weaker correlations with V-leak (<italic>r</italic> = 0.364, <italic>p</italic> = 0.006; <italic>r</italic> = 0.311, <italic>p</italic> = 0.020, respectively). The number of BV-AG-SSS was not correlated with V-leak. The ROC curve for contrast leakage exceeding 1000 voxels and the number of BV-incl had moderate accuracy, with an area under the curve of 0.871.


    </sec><sec>
    <title>Conclusion</title>
    The number of BV-incl may be a predictor of GBCA leakage and a biomarker for waste drainage function without using GBCA.



    </sec>

    DOI: 10.1007/s11604-021-01137-1

    PubMed

    Other Link: https://link.springer.com/article/10.1007/s11604-021-01137-1/fulltext.html

  36. MR Imaging of Endolymphatic Hydrops: Utility of iHYDROPS-Mi2 Combined with Deep Learning Reconstruction Denoising.

    Shinji Naganawa, Rei Nakamichi, Kazushige Ichikawa, Mariko Kawamura, Hisashi Kawai, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 3 ) page: 272 - 279   2021.9

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    PURPOSE: MRI of endolymphatic hydrops (EH) 4 h after intravenous administration of a single dose of gadolinium-based contrast agent is used for clinical examination in some institutions; however, further improvement in image quality would be valuable for wider clinical utility. Denoising using deep learning reconstruction (Advanced Intelligent Clear-IQ Engine [AiCE]) has been reported for CT and MR. The purpose of this study was to compare the contrast-to-noise ratio of endolymph to perilymph (CNREP) between the improved hybrid of reversed image of the positive endolymph signal and the native image of the perilymph signal multiplied with the heavily T2-weighted MR cisternography (iHYDROPS-Mi2) images, which used AiCE for the three source images (i.e. positive endolymph image [PEI], positive perilymph image [PPI], MR cisternography [MRC]) to those that did not use AiCE. We also examined if there was a difference between iHYDROPS-Mi2 images with and without AiCE for degree of visual grading of EH and in endolymphatic area [EL] ratios. METHODS: Nine patients with suspicion of EH were imaged on a 3T MR scanner. iHYDROPS images were generated by subtraction of PEI images from PPI images. iHYDROPS-Mi2 images were then generated by multiplying MRC with iHYDROPS images. The CNREP and EL ratio were measured on the iHYDROPS-Mi2 images. Degree of radiologist visual grading for EH was evaluated. RESULTS: Mean CNREP ± standard deviation was 1681.8 ± 845.2 without AiCE and 7738.6 ± 5149.2 with AiCE (P = 0.00002). There was no significant difference in EL ratio for images with and without AiCE. Radiologist grading for EH agreed completely between the 2 image types in both the cochlea and vestibule. CONCLUSION: The CNREP of iHYDROPS-Mi2 images with AiCE had more than a fourfold increase compared with that without AiCE. Use of AiCE did not adversely affect radiologist grading of EH.

    DOI: 10.2463/mrms.mp.2020-0082

    PubMed

  37. Relationship between Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space around the Cortical Veins after Intravenous Administration. Reviewed

    Shinji Naganawa, Rintaro Ito, Rei Nakamichi, Mariko Kawamura, Hisashi Kawai, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 3 ) page: 245 - 252   2021.9

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    PURPOSE: The purpose of this retrospective study was to investigate the relationship between the number and size of cystic structures around the cortical veins near the superior sagittal sinus and the leakage of gadolinium-based contrast agent (GBCA) around the cortical veins. METHODS: Of 190 patients (91 male and 99 female), that were scanned at 4 h after an intravenous injection of GBCA as a diagnostic examination for endolymphatic hydrops, 6 patients with GBCA leakage were younger than the previously proposed threshold age of 37.3 years for leakage. Six age-matched patients without leakage were also included for reference. In addition, we included 8 cases without leakage that were older than the hypothesized threshold of 37.3 years, as well as 8 age-matched patients with GBCA leakage into the cerebrospinal fluid space. The number of cysts was counted and the sizes were measured in these 28 patients (age: 32-60 years old, 13 men and 15 women). RESULTS: The mean number of cysts surrounding the cortical veins in the parasagittal region was 4.29 ± 1.77 vs. 1.79 ± 1.05 (P = 0.0001) in the subjects with and without GBCA leakage, respectively. The mean size of the largest cysts was at 8.89 ± 3.49 mm vs. 5.69 ± 2.29 (P = 0.009) in the subjects with and without GBCA leakage, respectively. CONCLUSION: The number and size of the perivenous cystic structures near the superior sagittal sinus is greater in subjects with GBCA leakage into the subarachnoid space compared with those without leakage. Future research regarding the histological and functional details of these parasagittal cystic structures is needed.

    DOI: 10.2463/mrms.mp.2020-0062

    PubMed

  38. Portal Vein Stenosis Following Liver Transplantation Hemodynamically Assessed with 4D-flow MRI before and after Portal Vein Stenting.

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yasuhiro Ogura, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 3 ) page: 231 - 235   2021.9

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    We present a case of a patient who underwent portal vein (PV) stenting for PV stenosis after a living-donor liver transplantation. A pretreatment 3D cine phase-contrast (4D-flow) MRI showed decreased, though hepatopetal, blood flow in the PV. After stenting, 4D-flow MRI confirmed an improvement in PV flow, with a more homogeneous flow distribution to each hepatic segment. 4D-flow MRI are valuable for understanding the hemodynamics of this area, planning for treatments, and evaluating the outcome of the interventions.

    DOI: 10.2463/mrms.ici.2020-0057

    PubMed

  39. Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study.

    Toshiaki Taoka, Rintaro Ito, Rei Nakamichi, Koji Kamagata, Mayuko Sakai, Hisashi Kawai, Toshiki Nakane, Takashi Abe, Kazushige Ichikawa, Junko Kikuta, Shigeki Aoki, Shinji Naganawa

    Japanese journal of radiology     2021.8

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    PURPOSE: The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was developed to evaluate the brain's glymphatic function or interstitial fluid dynamics. This study aimed to evaluate the reproducibility of the DTI-ALPS method and the effect of modifications in the imaging method and data evaluation. MATERIALS AND METHODS: Seven healthy volunteers were enrolled in this study. Image acquisition was performed for this test-retest study using a fixed imaging sequence and modified imaging methods which included the placement of region of interest (ROI), imaging plane, head position, averaging, number of motion-proving gradients, echo time (TE), and a different scanner. The ALPS-index values were evaluated for the change of conditions listed above. RESULTS: This test-retest study by a fixed imaging sequence showed very high reproducibility (intraclass coefficient = 0.828) for the ALPS-index value. The bilateral ROI placement showed higher reproducibility. The number of averaging and the difference of the scanner did not influence the ALPS-index values. However, modification of the imaging plane and head position impaired reproducibility, and the number of motion-proving gradients affected the ALPS-index value. The ALPS-index values from 12-axis DTI and 3-axis diffusion-weighted image (DWI) showed good correlation (r = 0.86). Also, a shorter TE resulted in a larger value of the ALPS-index. CONCLUSION: ALPS index was robust under the fixed imaging method even when different scanners were used. ALPS index was influenced by the imaging plane, the number of motion-proving gradient axes, and TE in the imaging sequence. These factors should be uniformed in the planning ALPS method studies. The possibility to develop a 3-axis DWI-ALPS method using three axes of the motion-proving gradient was also suggested.

    DOI: 10.1007/s11604-021-01187-5

    PubMed

  40. Dilatation of the Endolymphatic Space in the Ampulla of the Posterior Semicircular Canal: A New Clinical Finding Detected on Magnetic Resonance Imaging. International journal

    Masaru Morioka, Satofumi Sugimoto, Tadao Yoshida, Masaaki Teranishi, Masumi Kobayashi, Naoki Nishio, Naomi Katayama, Shinji Naganawa, Michihiko Sone

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   Vol. 42 ( 6 ) page: e643 - e647   2021.7

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    OBJECTIVES: To investigate the clinical features of ears with dilatation of the endolymphatic space in the ampulla of the posterior semicircular canal on magnetic resonance imaging. STUDY DESIGN: Retrospective study. SETTING: A university hospital. METHODS: This study included 1,842 ears from 934 patients who underwent 3-T magnetic resonance imaging with gadolinium to investigate the presence of endolymphatic hydrops. Age, sex distribution, hearing thresholds on pure-tone audiometry, and vestibular symptoms were compared between cases of unilateral and bilateral dilatation of the endolymphatic space in the ampulla of the posterior semicircular canal. RESULTS: Forty-eight ears (17 men and 14 women; mean age 49.9 yrs) showed dilatation of the endolymphatic space in the ampulla of the posterior semicircular canal. Age and the rate of chronic sensorineural hearing loss were significantly higher in the unilateral group (14 ears) than in the bilateral group (34 ears). The average hearing thresholds and rates of vestibular symptoms reported did not differ between unilateral and bilateral cases, but some patients showed positional nystagmus. CONCLUSIONS: Dilatation of the endolymphatic space in the ampulla was observed selectively in the posterior semicircular canal, though its pathogenesis was not clear. Such dilatation is not usually accompanied by vestibular endolymphatic hydrops, and it may be a cause of vertigo and dizziness.

    DOI: 10.1097/MAO.0000000000003073

    PubMed

  41. Age estimates from brain magnetic resonance images of children younger than two years of age using deep learning. International journal

    Masahiro Kawaguchi, Hiroyuki Kidokoro, Rintaro Ito, Anna Shiraki, Takeshi Suzuki, Yuki Maki, Masaharu Tanaka, Yoko Sakaguchi, Hiroyuki Yamamoto, Yosiyuki Takahashi, Shinji Naganawa, Jun Natsume

    Magnetic resonance imaging   Vol. 79   page: 38 - 44   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    The accuracy of brain age estimates from magnetic resonance (MR) images has improved with the advent of deep learning artificial intelligence (AI) models. However, most previous studies on predicting age emphasized aging from childhood to adulthood and old age, and few studies have focused on early brain development in children younger than 2 years of age. Here, we performed brain age estimates based on MR images in children younger than 2 years of age using deep learning. Our AI model, developed with one slice each of raw T1- and T2-weighted images from each subject, estimated brain age with a mean absolute error of 8.2 weeks (1.9 months). The estimates of our AI model were close to those of human specialists. The AI model also estimated the brain age of subjects with a myelination delay as significantly younger than the chronological age. These results indicate that the prediction accuracy of our AI model approached that of human specialists and that our simple method requiring less data and preprocessing facilitates a radiological assessment of brain development, such as monitoring maturational changes in myelination.

    DOI: 10.1016/j.mri.2021.03.004

    PubMed

  42. Diffusion analysis of fluid dynamics with incremental strength of motion proving gradient (DANDYISM) to evaluate cerebrospinal fluid dynamics

    Toshiaki Taoka, Hisashi Kawai, Toshiki Nakane, Takashi Abe, Rei Nakamichi, Rintaro Ito, Yuki Sato, Mayuko Sakai, Shinji Naganawa

    Japanese Journal of Radiology   Vol. 39 ( 4 ) page: 315 - 323   2021.4

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    <title>Abstract</title><sec>
    <title>Purpose</title>
    To visualize and analyze the dynamics of cerebrospinal fluid (CSF) motion in the cranium, we evaluated the distribution of motion-related signal dephasing by CSF on Diffusion ANalysis of fluid DYnamics with Incremental Strength of Motion proving gradient (DANDYISM) method, a composite imaging method using various low <italic>b</italic> values.



    </sec><sec>
    <title>Materials and methods</title>
    This study examined ten subjects aged 25–58. We acquired DWIs on a 3T clinical scanner with <italic>b</italic> values 0, 50, 100, 200, 300, 500, 700, and 1000 s/mm<sup>2</sup> in total imaging time of 4 min. We constructed DANDYISM images and evaluated the CSF area distribution with decreased motion-dephasing signal using a scoring method.


    </sec><sec>
    <title>Results</title>
    The DANDYISM images showed statistically significant higher CSF scores in the ventral posterior fossa, suprasellar cistern, and Sylvian vallecula compared to the lateral ventricle and frontal and parietal CSF spaces, indicating greater CSF movement in the former areas.


    </sec><sec>
    <title>Conclusion</title>
    The results indicated prominent CSF motions in the ventral portion of the posterior fossa, suprasellar cistern, and Sylvian fissure but smaller motions in the lateral ventricles and parietal subarachnoid space. This method may provide information of CSF dynamics in the clinical settings within short imaging time.


    </sec>

    DOI: 10.1007/s11604-020-01075-4

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    PubMed

    Other Link: http://link.springer.com/article/10.1007/s11604-020-01075-4/fulltext.html

  43. Variation in thyroid volumes due to differences in the measured length or area of the cross-sectional plane: A validation study of the ellipsoid approximation method using CT images.

    Fujita N, Kato K, Abe S, Naganawa S

    Journal of applied clinical medical physics   Vol. 22 ( 4 ) page: 15 - 25   2021.4

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    DOI: 10.1002/acm2.13125

    PubMed

  44. 【Precision Medicine時代のCardiac Imaging 2021 後編】MRI:循環器領域における臨床の最前線と技術の到達点 MRIの技術革新が広げる循環器画像診断の可能性 大血管の4D flow MRI

    櫻井 康雄, 竹原 康雄, 水野 崇, 阿部 真治, 長縄 慎二

    INNERVISION   Vol. 36 ( 5 ) page: 7 - 9   2021.4

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    MRIは、周辺技術の進歩により高画質、高速化が進められ、画像診断において重要な位置を占めている。MRによる生体内情報として、各組織のプロトンの密度、T1緩和、T2緩和、磁化率、拡散、血流、体液の流れ、灌流情報などの画像化、代謝情報が得られるが、その中で、血流や体液の流速を計測する試みは、位相コントラスト法を用いて古くから行われてきた。本稿では、血管領域に関する機能画像として、研究段階ではあるが、三次元の空間に時間軸情報を加えた三次元シネ位相コントラスト(phase contrast:PC)法である「4D flow MRI」について、主として大血管における現状を紹介する。(著者抄録)

  45. Intracranial Distribution of Intravenously Administered Gadolinium-based Contrast Agent over a Period of 24 Hours: Evaluation with 3D-real IR Imaging and MR Fingerprinting. Reviewed

    Shinji Naganawa, Rintaro Ito, Yutaka Kato, Hisashi Kawai, Toshiaki Taoka, Tadao Yoshida, Katsuya Maruyama, Katsutoshi Murata, Gregor Körzdörfer, Josef Pfeuffer, Mathias Nittka, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 20 ( 1 ) page: 91 - 98   2021.3

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    PURPOSE: To evaluate the feasibility for the detection of slight contrast effects after intravenous administration of single dose gadolinium-based contrast agent (IV-SD-GBCA), the time course of the GBCA distribution up to 24 h was examined in various fluid spaces and brain parenchyma using 3D-real IR imaging and MR fingerprinting (MRF). METHODS: Twenty-four patients with a suspicion of endolymphatic hydrops were scanned at pre-administration and at 10 min, 4 and 24 h post-IV-SD-GBCA. 3D-real IR images and MRF at the level of the internal auditory canal were obtained. The signal intensity on the 3D-real IR image of the cerebrospinal fluid (CSF) in the cerebellopontine angle cistern (CPA), Sylvian fissure (Syl), lateral ventricle (LV), and cochlear perilymph (CPL) was measured. The T1 and T2 values of cerebellar gray (GM) and white matter (WM) were measured using MRF. Each averaged value at the various time points was compared using an analysis of variance. RESULTS: The signal intensity on the 3D-real IR image in each CSF region peaked at 4 h, and was decreased significantly by 24 h (P< 0.05). All patients had a maximum signal intensity at 4 h in the CPA, and Syl. The mean CPL signal intensity peaked at 4 h and decreased significantly by 24 h (P < 0.05). All patients but two had a maximum signal intensity at 4 h. Regarding the T1 value in the cerebellar WM and GM, the T1 value at 10 min post-IV-GBCA was significantly decreased compared to the pre-contrast scan, but no significant difference was observed at the other time points. There was no significant change in T2 in the gray or white matter at any of the time points. CONCLUSION: Time course of GBCA after IV-SD-GBCA could be evaluated by 3D-real IR imaging in CSF spaces and in the brain by MRF.

    DOI: 10.2463/mrms.mp.2020-0030

    PubMed

  46. Time-resolved 3D cine phase-contrast magnetic resonance imaging (4D-flow MRI) can quantitatively assess portosystemic shunt severity and confirm normalization of portal flow after embolization of large portosystemic shunts. International journal

    Ryota Hyodo, Yasuo Takehara, Takashi Mizuno, Kazushige Ichikawa, Yoji Ishizu, Masataka Sugiyama, Shinji Naganawa

    Hepatology research : the official journal of the Japan Society of Hepatology   Vol. 51 ( 3 ) page: 343 - 349   2021.3

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    Diagnosis and severity assessments of portosystemic shunts (PSSs) are important because the pathology sometimes results in severe hepatic encephalopathy, which can be treated almost completely by shunt embolization. At present, morphological assessment of PSS is performed mainly by computed tomography, and ultrasound is used for blood flow assessment. In two cases of PSS-related hepatic encephalopathy, we used time-resolved 3D cine phase-contrast (4D-flow) magnetic resonance imaging (MRI) to assess blood flow before and after shunt embolization. Before the intervention, blood flow in the main trunk of the superior mesenteric vein was mostly hepatofugal. However, post-interventional 4D-flow MRI revealed hepatopetal superior mesenteric vein flow with significantly increased portal vein blood flow. 4D-flow MRI is an ideal adjunct to Doppler ultrasonography, allowing for objective and visual assessment of morphology and blood flow of the portal venous system, including PSSs, and is useful in determining the indications for, and outcome of, PSS embolization.

    DOI: 10.1111/hepr.13616

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    PubMed

  47. MRによる頭蓋内間質液・脳脊髄液動態の解明 Invited Reviewed

    長縄慎二、田岡俊昭、川井 恒

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成   Vol. - ( - ) page: 23 - 23   2021.3

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  48. Imaging of endolymphatic hydrops on a vertigo attack of Meniere's disease.

    Nakada T, Teranishi M, Sugiura S, Uchida Y, Naganawa S, Sone M

    Nagoya journal of medical science   Vol. 83 ( 1 ) page: 209 - 216   2021.2

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    DOI: 10.18999/nagjms.83.1.209

    PubMed

  49. コロナウイルス肺炎のAi診断 Invited Reviewed

    伊藤倫太郎、岩野信吾、長縄慎二

    臨床免疫・アレルギー科   Vol. 75 ( 2 ) page: 189 - 193   2021.2

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  50. Relationship between Time-dependent Signal Changes in Parasagittal Perivenous Cysts and Leakage of Gadolinium-based Contrast Agents into the Subarachnoid Space.

    Shinji Naganawa, Rintaro Ito, Rei Nakamichi, Mariko Kawamura, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2021.1

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    PURPOSE: To investigate the association between signal changes over time in perivenous cystic structures near the superior sagittal sinus and leakage of a gadolinium-based contrast agent (GBCA) into the subarachnoid space in patients with suspected endolymphatic hydrops. METHODS: Fifty-one cystic structures in 27 cases were evaluated. The signal intensity of the cystic structures was measured on 3D real inversion recovery (3D-real IR) images obtained at pre-, and at 10 min, 4 hrs and 24 hrs post-intravenous administration (IV) of GBCA. Signal enhancement of the cystic structures from the pre-contrast images at each time point was compared in subjects with leakage (positive) versus those without leakage (negative) using an ANOVA. Fisher's exact probability test was used to compare the maximum contrast-enhanced time point between positive and negative groups. We used 5% as a threshold to determine statistical significance. RESULTS: In leakage positive subjects, mean signal enhancement of the cysts was significantly greater at 4 and 24 hrs compared to 10 min. However, although there was a trend of an increase from 4 to 24 hrs, the difference was not significant. In the leakage negative group, mean signal enhancement of the cysts was significantly higher at 4 hrs compared to 10 min and 24 hrs. There was no significant difference between 10 min and 24 hrs. In the positive group, the maximum signal increase was found in 10/38 and 28/38 cysts at 4 and 24 hrs after IV-GBCA, respectively. In the leakage negative group, the maximum signal increase was found in 10/13 and 3/13 cysts at 4 and 24 hrs, respectively (P = 0.0019). CONCLUSION: There was an association between signal changes over time after IV-GBCA in perivenous cystic structures and leakage of GBCA. Further research to clarify the impact of cystic structures on the function of the waste clearance system of the brain is warranted.

    DOI: 10.2463/mrms.mp.2020-0138

    PubMed

  51. Iodine-related attenuation in contrast-enhanced dual-energy computed tomography in small-sized solid-type lung cancers is associated with the postoperative prognosis. International journal

    Shingo Iwano, Shinichiro Kamiya, Rintaro Ito, Shota Nakamura, Shinji Naganawa

    Cancer imaging : the official publication of the International Cancer Imaging Society   Vol. 21 ( 1 ) page: 7 - 7   2021.1

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    BACKGROUND: To investigate the correlation between iodine-related attenuation in contrast-enhanced dual-energy computed tomography (DE-CT) and the postoperative prognosis of surgically resected solid-type small-sized lung cancers. METHODS: We retrospectively reviewed the DE-CT findings and postoperative course of solid-type lung cancers ≤3 cm in diameter. After injection of iodinated contrast media, arterial phases were scanned using 140-kVp and 80-kVp tube voltages. Three-dimensional iodine-related attenuation (3D-IRA) of primary tumors at the arterial phase was computed using the "lung nodule" application software. The corrected 3D-IRA normalized to the patient's body weight and contrast medium concentration was then calculated. RESULTS: A total of 120 resected solid-type lung cancers ≤3 cm in diameter were selected for analysis (82 males and 38 females; mean age, 67 years). During the observation period (median, 47 months), 32 patients showed postoperative recurrence. Recurrent tumors had significantly lower 3D-IRA and corrected 3D-IRA at early phase compared to non-recurrent tumors (p = 0.046 and p = 0.027, respectively). The area under the receiver operating characteristic curve for postoperative recurrence was 0.624 for the corrected 3D-IRA at early phase (p = 0.025), and the cutoff value was 5.88. Kaplan-Meier curves for disease-free survival indicated that patients showing tumors with 3D-IRA > 5.88 had a significantly better prognosis than those with tumors showing 3D-IRA < 5.88 (p = 0.017). CONCLUSIONS: The 3D-IRA of small-sized solid-type lung cancers on contrast-enhanced DE-CT was significantly associated with postoperative prognosis, and low 3D-IRA tumors showed a higher TNM stage and a significantly poorer prognosis.

    DOI: 10.1186/s40644-020-00368-1

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    PubMed

  52. Evaluating the Effect of Arterial Pulsation on Cerebrospinal Fluid Motion in the Sylvian Fissure of Patients with Middle Cerebral Artery Occlusion Using Low b-value Diffusion-weighted Imaging

    Toshiaki Taoka, Hisashi Kawai, Toshiki Nakane, Takashi Abe, Rei Nakamichi, Rintaro Ito, Yutaro Sasaki, Ayumi Nishida, Shinji Naganawa

    Magnetic Resonance in Medical Sciences     2021.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society for Magnetic Resonance in Medicine  

    DOI: 10.2463/mrms.mp.2020-0121

    PubMed

  53. Lesion-specific prognosis by magnetic resonance imaging in sudden sensorineural hearing loss. International journal

    Cheng-Jui Yang, Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Masumi Kobayashi, Naoki Nishio, Shinji Naganawa, Michihiko Sone

    Acta oto-laryngologica   Vol. 141 ( 1 ) page: 5 - 9   2021.1

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    BACKGROUND: High signals in the inner ear of idiopathic sudden sensorineural hearing loss (ISSNHL) on magnetic resonance imaging (MRI) have been reported, but no quantitative evaluation has yet been done. OBJECTIVES: To evaluate hearing outcomes and cochlear signal intensities on 3-T heavily T2-weighted three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (hT2W-3D-FLAIR) in patients with ISSNHL. MATERIALS AND METHODS: Twenty-nine patients with ISSNHL were included. Patients underwent hT2W-3D-FLAIR with intravenous gadolinium injection and pure tone audiometry (PTA) at initial visits and 3 months later. Signal intensity ratios (SIRs) were measured in the basal or apical-middle turns of the affected cochlea. A statistical analysis of relationships between SIRs and the average hearing levels (HLs) at low (125, 250, and 500 Hz) and high (2, 4, and 8 kHz) tone frequencies was performed. RESULTS: Hearing improvements at high-tone frequencies in ears with HLs ≥60 dB were significantly worse in those with high SIRs at the basal turns on pre-contrast images. Similarly, hearing improvements at low-tone frequencies in ears with HLs ≥60 dB were significantly worse in those with high SIRs at the apical-middle turns on post-contrast images. CONCLUSIONS AND SIGNIFICANCE: High SIRs on hT2W-3D-FLAIR indicate cochlear disturbances with severe ISSNHL and could provide lesion-specific prognostic information.

    DOI: 10.1080/00016489.2020.1827159

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  54. 特集「世界の医療・Radiology:海外事情を覗き見よう」ドイツ編 Reviewed

    長縄慎二

    JCRニュース (日本放射線科専門医会・医会誌)   Vol. 238 ( - ) page: 11 - 13   2021

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  55. Three Dimensional Ultra-short Echo Time MRI Can Depict Cholesterol Components of Gallstones Bright.

    Mamoru Takahashi, Yasuo Takehara, Kenji Fujisaki, Tomoyuki Okuaki, Yukiko Fukuma, Norihiro Tooyama, Katsutoshi Ichijo, Tomoyasu Amano, Satoshi Goshima, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2020.12

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    PURPOSE: Non-calcified cholesterol stones that are small in size are hard to be depicted on CT or magnetic resonance cholangiopancreatography. This institutional review board (IRB)-approved retrospective in vitro study aims to characterize contrast behaviors of 3 main components of the gallstones, i.e., cholesterol component (CC), bilirubin calcium component (BC) and CaCO3 (CO) on 3D radial scan with ultrashort TE (UTE) MRI, and to test the capability of depicting CC of gallstones as bright signals as compared to background saline. METHODS: Fourteen representative gallstones from 14 patients, including 15 CC, 6 BC and 4 CO, were enrolled. The gallstones underwent MRI including fat-saturated T1-weighted image (fs-T1WI) and UTE MRI with dual echoes. The contrast-to-noise ratio (CNR) and the chemical analysis for the 25 portions of the stones were compared. RESULTS: BC was bright on fs-T1WI, which did not change dramatically on UTE MRI and the signal did not remain on UTE subtraction image between dual echoes. Whereas the CC was negative or faintly positive signal on fs-T1WI, bright signal on UTE MRI and the contrast remained even higher on the UTE subtraction, which reflected their short T2 values. Median CNRs and standard errors of the segments on each imaging were as follows: on fs-T1WI, -10.2 ± 4.2 for CC, 149.7 ± 27.6 for BC and 37.9 ± 14.3 for CO; on UTE MRI first echo, 16.7 ± 3.3 for CC, 74.9 ± 21.3 for BC and 17.7 ± 8.4 for CO; on UTE subtraction image, 30.2 ±2.0 for CC, -11.2 ± 5.4 for BC and 17.8 ± 10.7 for CO. Linear correlations between CNRs and cholesterol concentrations were observed on fs-T1WI with r = -0.885, (P < 0.0001), UTE MRI first echo r = -0.524 (P = 0.0072) and UTE subtraction with r = 0.598 (P = 0.0016). CONCLUSION: UTE MRI and UTE subtraction can depict CC bright.

    DOI: 10.2463/mrms.mp.2020-0009

    PubMed

  56. Optimal Plane Selection for Measuring Post-prandial Blood Flow Increase within the Superior Mesenteric Artery: Analysis Using 4D Flow and Computational Fluid Dynamics. Reviewed

    Masataka Sugiyama, Yasuo Takehara, Masanori Kawate, Naoki Ooishi, Masaki Terada, Haruo Isoda, Harumi Sakahara, Shinji Naganawa, Kevin M Johnson, Oliver Wieben, Tetsuya Wakayama, Atsushi Nozaki, Hiroyuki Kabasawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 4 ) page: 366 - 374   2020.12

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    PURPOSE: 2D cine phase contrast (PC)-MRI is a standard velocimetry for the superior mesenteric artery (SMA); however, the optimal localization of the measurement plane has never been fully discussed previously. The purpose of this Institutional Review Board approved prospective and single arm study is to test whether flow velocimetry of the SMA with combined use of 2D cine PC-MRI and meal challenge is dependent on the localizations of the measurement planes and to seek optimal section for velocimetry. METHODS: Seven healthy volunteers underwent cardiac phase resolved ECG gated 2D cine PC-MRI pre- and 30 min post-meal challenge at three measurement planes: proximal, curved mid section and distal straight section of the SMA at 3T. 4D Flow using 3D cine PC-MRI with vastly undersampled isotropic projection imaging (PC VIPR) was also performed right after 2D cine PC-MRI to delineate the flow dynamics within the SMA using streamline analysis. Two radiologists measured flow velocities, and rated the appearances of the abnormal flow in the SMA on streamlines derived from the 4D Flow and the computational fluid dynamics (CFD). RESULTS: 2D cine PC-MRI measured increased temporally averaged flow velocity (mm/s) after the meal challenge only in the proximal (129.3 vs. 97.8, P = 0.0313) and distal section (166.9 vs. 96.2, P = 0.0313), not in the curved mid section (113.1 vs. 85.5, P = 0.0625). The average velocities were highest and their standard errors (8.5-26.5) were smallest at the distal straight section both before and after the meal challenge as compared with other sections. The streamline analysis depicted more frequent appearances of vertical or helical flow in the curved mid section both on 4D Flow and CFD (κ: 0.27-0.68). CONCLUSION: SMA velocimetry with 2D cine PC-MRI was dependent on the localization of the measurement planes. Distal straight section, not in the curved mid section is recommended for MR velocimetry.

    DOI: 10.2463/mrms.mp.2019-0089

    PubMed

  57. Confirmation of Age-dependence in the Leakage of Contrast Medium around the Cortical Veins into Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agent. Reviewed

    Shinji Naganawa, Rintaro Ito, Hisashi Kawai, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 4 ) page: 375 - 381   2020.12

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    PURPOSE: It has been reported previously that intravenously administered gadolinium-based contrast agent (GBCA) leaks into the subarachnoid space around the cortical veins at 4 h after injection in all old people over 37 years, but not in younger people up to 37 years of age in 3D-real IR images. The purpose of this study was to investigate whether there was a strict threshold of 37 years of age for the leakage of the GBCA into the subarachnoid space. METHODS: The subjects included 190 patients, that were scanned for 3D-real IR images at 4 hours after intravenous injection of GBCA as a diagnostic test for endolymphatic hydrops. The patient's age ranged from 14 to 81 years. Two experienced neuroradiologists evaluated the images to determine whether the GBCA leakage around the cortical veins was positive or negative. Any discrepancies between the two observers were discussed and a consensus was obtained.A Mann-Whitney U test and receiver operating characteristic (ROC) curve analysis were used to compare the positive and the negative group and to set the age cut-off value for the prediction of GBCA leakage. RESULTS: The GBCA leakage around the cortical veins was negative in 35 patients and positive in 155 patients. The average age was 33 ± 11 years in the negative group, and 55 ± 12 years in the positive group (P < 0.01). In the ROC analysis for the age and leakage of the GBCA, an area under the curve was 0.905 and the cut-off age was 37.317 years (sensitivity of 0.942 and specificity of 0.771). CONCLUSION: Intravenously administered GBCA leaks into the subarachnoid space around the cortical veins in most patients over 37 years of age. However, it should be noted that it can be found occasionally in patients under 37 years of age.

    DOI: 10.2463/mrms.mp.2019-0182

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  58. Assessing the Risk of Intracranial Aneurysm Rupture Using Morphological and Hemodynamic Biomarkers Evaluated from Magnetic Resonance Fluid Dynamics and Computational Fluid Dynamics. Reviewed

    Roshani Perera, Haruo Isoda, Kenta Ishiguro, Takashi Mizuno, Yasuo Takehara, Masaki Terada, Chiharu Tanoi, Takehiro Naito, Harumi Sakahara, Hisaya Hiramatsu, Hiroki Namba, Takashi Izumi, Toshihiko Wakabayashi, Takafumi Kosugi, Yuki Onishi, Marcus Alley, Yoshiaki Komori, Mitsuru Ikeda, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 4 ) page: 333 - 344   2020.12

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    PURPOSE: Evaluate in vivo hemodynamic and morphological biomarkers of intracranial aneurysms, using magnetic resonance fluid dynamics (MRFD) and MR-based patient specific computational fluid dynamics (CFD) in order to assess the risk of rupture. METHODS: Forty-eight intracranial aneurysms (10 ruptured, 38 unruptured) were scrutinized for six morphological and 10 hemodynamic biomarkers. Morphological biomarkers were calculated based on 3D time-of-flight magnetic resonance angiography (3D TOF MRA) in MRFD analysis. Hemodynamic biomarkers were assessed using both MRFD and CFD analyses. MRFD was performed using 3D TOF MRA and 3D cine phase-contrast magnetic resonance imaging (3D cine PC MRI). CFD was performed utilizing patient specific inflow-outflow boundary conditions derived from 3D cine PC MRI. Univariate analysis was carried out to identify statistically significant biomarkers for aneurysm rupture and receiver operating characteristic (ROC) analysis was performed for the significant biomarkers. Binary logistic regression was performed to identify independent predictive biomarkers. RESULTS: Morphological biomarker analysis revealed that aneurysm size [P = 0.021], volume [P = 0.035] and size ratio [P = 0.039] were statistically significantly different between the two groups. In hemodynamic biomarker analysis, MRFD results indicated that ruptured aneurysms had higher oscillatory shear index (OSI) [OSI.max, P = 0.037] and higher relative residence time (RRT) [RRT.ave, P = 0.035] compared with unruptured aneurysms. Correspondingly CFD analysis demonstrated significant differences for both average and maximum OSI [OSI.ave, P = 0.008; OSI.max, P = 0.01] and maximum RRT [RRT.max, P = 0.045]. ROC analysis revealed AUC values greater than 0.7 for all significant biomarkers. Aneurysm volume [AUC, 0.718; 95% CI, 0.491-0.946] and average OSI obtained from CFD [AUC, 0.774; 95% CI, 0.586-0.961] were retained in the respective logistic regression models. CONCLUSION: Both morphological and hemodynamic biomarkers have significant influence on intracranial aneurysm rupture. Aneurysm size, volume, size ratio, OSI and RRT could be potential biomarkers to assess aneurysm rupture risk.

    DOI: 10.2463/mrms.mp.2019-0107

    PubMed

  59. A case of stent-graft implantation for postpancreaticoduodenectomy hemorrhage in a patient with a reconstructed gastric tube

    Tomohiro Komada, Yasushi Tachi, Ken Nagasaka, Suguru Yamada, Masaya Matsushima, Yutaro Sakaki, Shinji Naganawa

    Radiology Case Reports   Vol. 15 ( 12 ) page: 2710 - 2713   2020.12

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    DOI: 10.1016/j.radcr.2020.10.021

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  60. Evaluation of magnetic resonance angiography as a possible alternative to rotational angiography or computed tomography angiography for assessing cerebrovascular computational fluid dynamics.

    Yoneyama Y, Isoda H, Ishiguro K, Terada M, Kamiya M, Otsubo K, Perera R, Mizuno T, Fukuyama A, Takiguchi K, Watanabe T, Kosugi T, Komori Y, Naganawa S

    Physical and engineering sciences in medicine   Vol. 43 ( 4 ) page: 1327 - 1337   2020.12

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    DOI: 10.1007/s13246-020-00936-6

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  61. 【基調論文】CTおよびMRIなどの画像診断装置の今後の展望 Reviewed

    長縄慎二

    月間新医療データブック・シリーズ 医療機器システム白書   Vol. - ( - ) page: 14 - 18   2020.12

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  62. 【特集】 マネジメントに苦慮する疾患: Is it benign, malignant or insignificant? 1. 甲状腺病変の診断とマネジメント Invited Reviewed

    石垣聡子、佐竹弘子、松本篤子、林 葉子、清水友理、長縄慎二

    日獨医報   Vol. 65 ( 1 ) page: 5 - 11   2020.12

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  63. Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio. International journal

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Reiko Ohdake, Michihito Masuda, Aya Ogura, Toshiyasu Kato, Shuji Koyama, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

    NeuroImage   Vol. 222   page: 117241 - 117241   2020.11

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    Neuroimaging studies have shown that the brain is functionally organized into several large-scale brain networks. Within these networks are regions that are widely connected to several other regions within and/or outside the network. Regions that connect to several other networks, known as connector hubs, are believed to be crucial for information transfer and between-network communication within the brain. To identify regions with high between-network connectivity at the voxel level, we introduced a novel metric called functional connectivity overlap ratio (FCOR), which quantifies the spatial extent of a region's connection to a given network. Using resting state functional magnetic resonance imaging data, FCOR maps were generated for several well-known large-scale resting state networks (RSNs) and used to examine the relevant associations among different RSNs, identify connector hub regions in the cerebral cortex, and elucidate the hierarchical functional organization of the brain. Constructed FCOR maps revealed a strong association among the core neurocognitive networks (default mode, salience, and executive control) as well as among primary processing networks (sensorimotor, auditory, and visual). Prominent connector hubs were identified in the bilateral middle frontal gyrus, posterior cingulate, lateral parietal, middle temporal, dorsal anterior cingulate, and anterior insula, among others, regions mostly associated with the core neurocognitive networks. Finally, clustering the whole brain using FCOR features yielded a topological organization that arranges brain regions into a hierarchy of information processing systems with the primary processing systems at one end and the heteromodal systems comprising connector hubs at the other end.

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  64. Effects of Head Motion on the Evaluation of Age-related Brain Network Changes Using Resting State Functional MRI.

    Sanae Kato, Epifanio Bagarinao, Haruo Isoda, Shuji Koyama, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Masahisa Katsuno, Minoru Hoshiyama, Shinji Naganawa, Norio Ozaki, Gen Sobue

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2020.10

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    PURPOSE: The estimation of functional connectivity (FC) measures using resting state functional MRI (fMRI) is often affected by head motion during functional imaging scans. Head motion is more common in the elderly than in young participants and could therefore affect the evaluation of age-related changes in brain networks. Thus, this study aimed to investigate the influence of head motion in FC estimation when evaluating age-related changes in brain networks. METHODS: This study involved 132 healthy volunteers divided into 3 groups: elderly participants with high motion (OldHM, mean age (±SD) = 69.6 (±5.31), N = 44), elderly participants with low motion (OldLM, mean age (±SD) = 68.7 (±4.59), N = 43), and young adult participants with low motion (YugLM, mean age (±SD) = 27.6 (±5.26), N = 45). Head motion was quantified using the mean of the framewise displacement of resting state fMRI data. After preprocessing all resting state fMRI datasets, several resting state networks (RSNs) were extracted using independent component analysis (ICA). In addition, several network metrics were also calculated using network analysis. These FC measures were then compared among the 3 groups. RESULTS: In ICA, the number of voxels with significant differences in RSNs was higher in YugLM vs. OldLM comparison than in YugLM vs. OldHM. In network analysis, all network metrics showed significant (P < 0.05) differences in comparisons involving low vs. high motion groups (OldHM vs. OldLM and OldHM vs. YugLM). However, there was no significant (P > 0.05) difference in the comparison involving the low motion groups (OldLM vs. YugLM). CONCLUSION: Our findings showed that head motion during functional imaging could significantly affect the evaluation of age-related brain network changes using resting state fMRI data.

    DOI: 10.2463/mrms.mp.2020-0081

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  65. Change of White Matter Integrity in Children With Hematopoietic Stem Cell Transplantation. International journal

    Yoko Sakaguchi, Jun Natsume, Hiroyuki Kidokoro, Masaharu Tanaka, Yu Okai, Yuji Ito, Hiroyuki Yamamoto, Atsuko Ohno, Tomohiko Nakata, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Hideki Muramatsu, Shinji Naganawa, Yoshiyuki Takahashi

    Pediatric neurology   Vol. 111   page: 78 - 84   2020.10

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    BACKGROUND: Advances in hematopoietic stem cell transplantation have improved the survival rate of malignant diseases and congenital immunodeficiencies. It has become important to assess long-term complications in survivors. To assess neurological abnormalities in children treated by transplantation, diffusion tensor imaging was performed. METHODS: Forty children who underwent head diffusion tensor imaging before and after their first transplantation were enrolled. Patients with brain lesions on conventional MRI were excluded. Fractional anisotropy and mean diffusivity were compared between patients and 28 control subjects using tract-based spatial statistics. The Strengths and Difficulties Questionnaire was administered as a behavioral evaluation after transplantation, and diffusion tensor images of patients with and without behavioral abnormalities were compared. RESULTS: The age of patients and controls was 0 to 19 years and 0 to 16 years, respectively. The date of diffusion tensor imaging was 10 to 57 days before and 40 to 153 days after transplantation. Tract-based spatial statistics showed fractional anisotropy reduction in widespread white matter in patients before and after transplantation. Mean diffusivity was high before transplantation and normalized after transplantation. Analysis comparing before and after hematopoietic stem cell transplantation shows no difference in fractional anisotropy and a higher mean diffusivity before hematopoietic stem cell transplantation. In patients with behavioral abnormalities, low fractional anisotropy and high mean diffusivity remained after transplantation. CONCLUSIONS: Longitudinal diffusion tensor imaging showed white matter abnormalities in children without conventional MRI abnormalities, which were related to behavioral problems after transplantation. Diffusion tensor imaging is useful for behavioral assessment in children undergoing transplantation.

    DOI: 10.1016/j.pediatrneurol.2020.06.008

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  66. Significance of high signal intensity in the endolymphatic duct on magnetic resonance imaging in ears with otological disorders. Reviewed International journal

    Kyoko Morimoto, Tadao Yoshida, Masumi Kobayashi, Satofumi Sugimoto, Naoki Nishio, Masaaki Teranishi, Shinji Naganawa, Michihiko Sone

    Acta oto-laryngologica   Vol. 140 ( 10 ) page: 818 - 822   2020.10

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    BACKGROUND: High signal intensity in the endolymphatic duct (ED) is occasionally observed on magnetic resonance imaging (MRI) in ears that have otological disorders. OBJECTIVE: The signal intensity (SI) in the ED on post-contrast MRI was investigated in subjects with various otological disorders, and the meaning of high SI in the ED was evaluated. MATERIAL AND METHODS: 392 patients with otological disorders and 21 controls without otological symptoms underwent 3 T MRI. The SIs of the ED and the cerebellum were measured, the SI ratio (SIR) was calculated, and ears with SIR ≥4 were identified. RESULTS: A high SIR was identified in the ED of 3.7% of ears affected by definite Meniere's disease (dMD), 100% of ears affected by large vestibular aqueduct syndrome (LVAS), and 7.1% of ears with no otological symptoms. On the whole, a significant relationship was found between the existence of vestibular or cochlear EH and the SIR in the ED. CONCLUSION: The MRI finding of high SI in the ED may indicate the mechanism of inner ear disturbances in ears with otological disorders, especially in those with LVAS, and it may suggest an underlying disorder in some ears in which otological symptoms are not apparent.

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  67. A review on the use of artificial intelligence for medical imaging of the lungs of patients with coronavirus disease 2019. International journal

    Rintaro Ito, Shingo Iwano, Shinji Naganawa

    Diagnostic and interventional radiology (Ankara, Turkey)   Vol. 26 ( 5 ) page: 443 - 448   2020.9

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    The results of research on the use of artificial intelligence (AI) for medical imaging of the lungs of patients with coronavirus disease 2019 (COVID-19) has been published in various forms. In this study, we reviewed the AI for diagnostic imaging of COVID-19 pneumonia. PubMed, arXiv, medRxiv, and Google scholar were used to search for AI studies. There were 15 studies of COVID-19 that used AI for medical imaging. Of these, 11 studies used AI for computed tomography (CT) and 4 used AI for chest radiography. Eight studies presented independent test data, 5 used disclosed data, and 4 disclosed the AI source codes. The number of datasets ranged from 106 to 5941, with sensitivities ranging from 0.67-1.00 and specificities ranging from 0.81-1.00 for prediction of COVID-19 pneumonia. Four studies with independent test datasets showed a breakdown of the data ratio and reported prediction of COVID-19 pneumonia with sensitivity, specificity, and area under the curve (AUC). These 4 studies showed very high sensitivity, specificity, and AUC, in the range of 0.9-0.98, 0.91-0.96, and 0.96-0.99, respectively.

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  68. 第21回山形めまい研究会 特別講演Ⅰ MR imaging of endolymphatic hydrops; What is right, what is wrong, and what is new Invited Reviewed

    長縄慎二

    耳鼻咽喉科山形 (日本耳鼻咽喉科学会山形県地方部会誌)   Vol. 24 ( - ) page: 54 - 55   2020.9

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  69. Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis. International journal

    Shao Wei Choy, Epifanio Bagarinao, Hirohisa Watanabe, Eric Tatt Wei Ho, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshiaki Taoka, Shuji Koyama, Hiroki C Tanabe, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

    Human brain mapping   Vol. 41 ( 12 ) page: 3198 - 3211   2020.8

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    White matter (WM) fiber bundles change dynamically with age. These changes could be driven by alterations in axonal diameter, axonal density, and myelin content. In this study, we applied a novel fixel-based analysis (FBA) framework to examine these changes throughout the adult lifespan. Using diffusion-weighted images from a cohort of 293 healthy volunteers (89 males/204 females) from ages 21 to 86 years old, we performed FBA to analyze age-related changes in microscopic fiber density (FD) and macroscopic fiber morphology (fiber cross section [FC]). Our results showed significant and widespread age-related alterations in FD and FC across the whole brain. Interestingly, some fiber bundles such as the anterior thalamic radiation, corpus callosum, and superior longitudinal fasciculus only showed significant negative relationship with age in FD values, but not in FC. On the other hand, some segments of the cerebello-thalamo-cortical pathway only showed significant negative relationship with age in FC, but not in FD. Analysis at the tract-level also showed that major fiber tract groups predominantly distributed in the frontal lobe (cingulum, forceps minor) exhibited greater vulnerability to the aging process than the others. Differences in FC and the combined measure of FD and cross section values observed between sexes were mostly driven by differences in brain sizes although male participants tended to exhibit steeper negative linear relationship with age in FD as compared to female participants. Overall, these findings provide further insights into the structural changes the brain's WM undergoes due to the aging process.

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  70. Comprehensive Evaluation of B1+-corrected FISP-based Magnetic Resonance Fingerprinting: Accuracy, Repeatability and Reproducibility of T1 and T2 Relaxation Times for ISMRM/NIST System Phantom and Volunteers. Reviewed

    Yutaka Kato, Kazushige Ichikawa, Kuniyasu Okudaira, Toshiaki Taoka, Hirokazu Kawaguchi, Katsutoshi Murata, Katsuya Maruyama, Gregor Koerzdoerfer, Josef Pfeuffer, Mathias Nittka, Shinji Naganawa

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 3 ) page: 168 - 175   2020.8

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    PURPOSE: This study aimed to evaluate comprehensively; accuracy, repeatability and reproducibility of T1 and T2 relaxation times measured by magnetic resonance fingerprinting using B1+-corrected fast imaging with steady-state precession (FISP-MRF). METHODS: The International Society of Magnetic Resonance in Medicine/National Institute of Standards and Technology (ISMRM/NIST) phantom was scanned for 100 days, and six healthy volunteers for 5 days using a FISP-MRF prototype sequence. Accuracy was evaluated on the phantom by comparing relaxation times measured by FISP-MRF with the reference values provided by the phantom manufacturer. Daily repeatability was characterized as the coefficient of variation (CV) of the measurements over 100 days for the phantom and over 5 days for volunteers. In addition, the cross-scanner reproducibility was evaluated in volunteers. RESULTS: In the phantom study, T1 and T2 values from FISP-MRF showed a strong linear correlation with the reference values of the phantom (R2 = 0.9963 for T1; R2 = 0.9966 for T2). CVs were <1.0% for T1 values larger than 300 ms, and <3.0% for T2 values across a wide range. In the volunteer study, CVs for both T1 and T2 values were <5.0%, except for one subject. In addition, all T2 values estimated by FISP-MRF in vivo were lower than those measured with conventional mapping sequences reported in previous studies. The cross-scanner variation of T1 and T2 showed good agreement between two different scanners in the volunteers. CONCLUSION: B1+-corrected FISP-MRF showed an acceptable accuracy, repeatability and reproducibility in the phantom and volunteer studies.

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  71. Abnormal Flow Dynamics Result in Low Wall Shear Stress and High Oscillatory Shear Index in Abdominal Aortic Dilatation: Initial in vivo Assessment with 4D-flow MRI. Reviewed

    Yasuo Takehara, Haruo Isoda, Mamoru Takahashi, Naoki Unno, Norihiko Shiiya, Takasuke Ushio, Satoshi Goshima, Shinji Naganawa, Marcus Alley, Tetsuya Wakayama, Atsushi Nozaki

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 3 ) page: 235 - 246   2020.8

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    PURPOSE: To characterize the non-laminar flow dynamics and resultant decreased wall shear stress (WSS) and high oscillatory shear index (OSI) of the infrarenal abdominal aortic dilatation, cardiac phase-resolved 3D phase-contrast MRI (4D-flow MRI) was performed. METHODS: The prospective single-arm study was approved by the Institutional Review Board and included 18 subjects (median 67.5 years) with the dilated infrarenal aorta (median diameter 35 mm). 4D-flow MRI was conducted on a 1.5T MRI system. On 3D streamline images, laminar and non-laminar (i.e., vortex or helical) flow patterns were visually assessed both for the dilated aorta and for the undilated upstream aorta. Cardiac phase-resolved flow velocities, WSS and OSI, were also measured for the dilated aorta and the upstream undilated aorta. RESULTS: Non-laminar flow represented by vortex or helical flow was more frequent and overt in the dilated aorta than in the undilated upstream aorta (P < 0.0156) with a very good interobserver agreement (weighted kappa: 0.82-1.0). The WSS was lower, and the OSI was higher on the dilated aortic wall compared with the proximal undilated segments. In mid-systole, mean spatially-averaged WSS was 0.20 ± 0.016 Pa for the dilated aorta vs. 0.68 ± 0.071 Pa for undilated upstream aorta (P < 0.0001), and OSI on the dilated aortic wall was 0.093 ± 0.010 vs. 0.041 ± 0.0089 (P = 0.013). The maximum values and the amplitudes of the WSS at the dilated aorta were inversely proportional to the ratio of dilated/undilated aortic diameter (r = -0.694, P = 0.0014). CONCLUSION: 4D-flow can characterize abnormal non-laminar flow dynamics within the dilated aorta in vivo. The wall of the infrarenal aortic dilatation is continuously and increasingly affected by atherogenic stimuli due to the flow disturbances represented by vortex or helical flow, which is reflected by lower WSS and higher OSI.

    DOI: 10.2463/mrms.mp.2019-0188

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  72. Efficacy and safety of accelerated fractionated radiotherapy without elective nodal irradiation for T3N0 glottic cancer without vocal cord fixation. Reviewed International journal

    Masayuki Okumura, Atsushi Motegi, Sadamoto Zenda, Naoki Nakamura, Hidehiro Hojo, Masaki Nakamura, Yasuhiro Hirano, Shun-Ichiro Kageyama, Satoko Arahira, Raturi Vijay Parshuram, Hirofumi Kuno, Ryuichi Hayashi, Makoto Tahara, Yoshiyuki Itoh, Shinji Naganawa, Tetsuo Akimoto

    Head & neck   Vol. 42 ( 8 ) page: 1775 - 1782   2020.8

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    BACKGROUND: The purpose of this study was to evaluate accelerated fractionated radiotherapy (AFRT) without elective nodal irradiation (ENI) for T3N0 glottic cancer (GC) without vocal cord fixation, especially in comparison with chemoradiotherapy (CRT) and hyperfractionated radiotherapy (HFRT) both of which included ENI. METHODS: The medical charts of patients with T3N0GC without cord fixation received definitive radiotherapy between June 2005 and March 2018 were reviewed. RESULTS: A total of 74 patients were analyzed. After a median follow-up time of 46 months (range, 12-141), 3-year local failure in AFRT/CRT/HFRT (n = 41/10/23) was 10%/20%/26%, 3-year regional failure 6%/0%/9%, 3-year progression-free survival 71%/69%/74%, and 3-year overall survival 77%/100%/87%. There were no significant differences among three groups in recurrence or survival. Grade 3 adverse events (AEs) were noted in 5/2/8 patients (12%/20%/35%) in AFRT/CRT/HFRT, respectively. There were no Grade 4/5 AEs. CONCLUSIONS: AFRT without ENI is an effective and feasible treatment for T3N0GC without cord fixation.

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  73. Effects of endolymphatic hydrops on acoustic energy absorbance. Reviewed International journal

    Masumi Kobayashi, Tadao Yoshida, Satofumi Sugimoto, Mariko Shimono, Masaaki Teranishi, Shinji Naganawa, Michihiko Sone

    Acta oto-laryngologica   Vol. 140 ( 8 ) page: 626 - 631   2020.8

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    Background: The presence of endolymphatic hydrops (EH) may cause hearing loss and affect the transmission of acoustic energy to the inner ear.Objectives: Acoustic energy absorbance on wideband acoustic immittance (WAI) was evaluated, focusing especially on EH in the vestibule.Material and methods: A total of 32 ears from 16 patients who underwent 3-T magnetic resonance imaging (MRI) to evaluate the presence of EH were examined, retrospectively. The degree of EH in the vestibule was classified into three grades (no, mild, and significant), and pure tone audiometry (PTA) and WAI were measured before and after a glycerol drip.Results: Ears with significant EH showed significantly higher hearing levels and air-bone gaps (ABG), and higher absorbance values on WAI at low frequencies (560-600 Hz) than ears with mild or no EH. Changes in absorbance values were observed in some ears without threshold change on PTA.Conclusions and Significance: This study showed significantly higher absorbance values of acoustic energy with significant vestibular EH at low frequencies. Considering ABGs observed in ears with significant EH, the presence of EH in the vestibule might cause an obstacle to the transmission of acoustic energy to the inner ear.

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  74. ロボット支援前立腺全摘除術後の難治性乳び腹水に対してリンパ管塞栓術が奏功した一例

    兵藤 良太, 山田 恵一郎, 堀口 瞭太, 伊藤 準, 松島 正哉, 駒田 智大, 大脇 貴之, 竹原 康雄, 長縄 慎二

    日本インターベンショナルラジオロジー学会雑誌   Vol. 35 ( Suppl. ) page: 290 - 290   2020.8

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  75. A phase I/II trial of intraoperative breast radiotherapy in an Asian population: 10-year results with critical evaluation. International journal

    Mariko Kawamura, Yoshiyuki Itoh, Takeshi Kamomae, Masataka Sawaki, Toyone Kikumori, Nobuyuki Tsunoda, Junji Ito, Yoshie Shimoyama, Hiroko Satake, Shinji Naganawa

    Journal of radiation research   Vol. 61 ( 4 ) page: 602 - 607   2020.7

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    Although phase III trials have been published comparing whole breast irradiation (WBI) with accelerated partial breast irradiation (APBI) using intraoperative radiotherapy (IORT), long-term follow-up results are lacking. We report the 10-year follow-up results of a prospective phase I/II clinical trial of IORT. The inclusion criteria were as follows: (i) tumor size <2.5 cm, (ii) desire for breast-conserving surgery, (iii) age >50 years, (iv) negative margins after resection and (v) sentinel lymph node-negative disease. A single dose of IORT (19-21 Gy) was delivered to the tumor bed in the operation room just after wide local excision of the primary breast cancer using a 6-12 MeV electron beam. Local recurrence was defined as recurrence or new disease within the treated breast and was evaluated annually using mammography and ultrasonography. A total of 32 patients were eligible for evaluation. The median patient age was 65 years and the median follow-up time was 10 years. Two patients experienced local recurrence just under the nipple, out of the irradiated field, after 8 years of follow-up. Three patients had contralateral breast cancer and one patient experienced bone metastasis after 10 years of follow-up. No patient experienced in-field recurrence nor breast cancer death. Eight patients had hypertrophic scarring at the last follow-up. There were no lung or heart adverse effects. This is the first report of 10-year follow-up results of IORT as APBI. The findings suggest that breast cancer with extended intraductal components should be treated with great caution.

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  76. Evaluation of segment 4 portal vein embolization added to right portal vein for right hepatic trisectionectomy: a retrospective propensity score-matched study. Reviewed

    Jun Ito, Tomohiro Komada, Kojiro Suzuki, Masaya Matsushima, Masahiro Nakatochi, Yumiko Kobayashi, Tomoki Ebata, Shinji Naganawa, Masato Nagino

    Journal of hepato-biliary-pancreatic sciences   Vol. 27 ( 6 ) page: 299 - 306   2020.6

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    BACKGROUND: Adding segment 4 (S4) portal vein embolization (PVE) to right PVE before right hepatic trisectionectomy is controversial. We retrospectively examined the effect of S4 PVE on segments 2 and 3 (S2+3) hypertrophy. METHODS: We reviewed patients with biliary carcinoma who underwent right PVE with (R3PVE) or without (R2PVE) S4 PVE using gelatin sponge particles and coils (2010-2019). Propensity score matching balanced the cohort for baseline characteristics, including total liver volume and S2+3 volume before PVE. We compared the groups regarding the S2+3 volume changes after PVE. RESULTS: Of 178 enrolled patients, 38 underwent R3PVE for right hepatic trisectionectomy and 140 underwent R2PVE for right hepatectomy. Twenty-eight patients from each group were respectively matched. The median absolute volume increase in (146 cm3 vs 70 cm3 ), hypertrophy rate of (52.4% vs 32.3%), and kinetic growth rate of (3.1 %/week vs 2.0 %/week) S2+3 were significantly higher in the R3PVE group than in the R2PVE group. In the pre-matched cohort, the rate of posthepatectomy liver failure and postoperative hospital stay did not significantly differ between the patients who underwent right hepatic trisectionectomy and right hepatectomy. CONCLUSION: R3PVE increased the S2+3 volume more effectively than R2PVE in patients with biliary carcinoma.

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  77. Quantification of Endolymphatic Space Volume after Intravenous Administration of a Single Dose of Gadolinium-based Contrast Agent: 3D-real Inversion Recovery versus HYDROPS-Mi2. Reviewed

    Toshio Ohashi, Shinji Naganawa, Ai Takeuchi, Toshio Katagiri, Kayao Kuno

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 2 ) page: 119 - 124   2020.5

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    PURPOSE: Recently, the use of 3D real inversion recovery (3D-real IR) imaging has been proposed for the evaluation of endolymphatic hydrops (EH). This method shows similar contrast between the endolymphatic and perilymphatic spaces and surrounding bone compared with the hybrid of reversed image of positive endolymph signal and native image of perilymph signal multiplied with heavily T2-weighted MR cisternography (HYDROPS-Mi2) image. We measured the volume of the endolymphatic space using 3D-real IR and HYDROPS-Mi2 images, and compared the measurements obtained with both techniques. METHODS: HYDROPS-Mi2 and 3D-real IR images were obtained for 30 ears from 15 patients with clinical suspicion of EH; imaging was performed 4 h after intravenous administration of a single dose of gadolinium-based contrast agent. We measured the volume of the endolymphatic space in the cochlea and vestibule by manually drawing the regions of interest. The correlation between endolymphatic volume determined from HYDROPS-Mi2 images and 3D-real IR images was calculated. RESULTS: There was a strong positive linear correlation between the cochlear and vestibular endolymphatic volume determined from HYDROPS-Mi2 and 3D-real IR images. The Spearman's rank correlation coefficient (ρ) between the measurements obtained with both images was 0.805 (P < 0.001) for the cochlea and 0.826 (P < 0.001) for the vestibule. CONCLUSION: The endolymphatic volume measured using 3D-real IR images strongly correlated with that measured using HYDROPS-Mi2 images. Thus, 3D-real IR imaging might be a suitable method for the measurement of endolymphatic volume.

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  78. Detection of IV-gadolinium Leakage from the Cortical Veins into the CSF Using MR Fingerprinting. Reviewed

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Hirokazu Kawaguchi, Katsuya Maruyama, Katsutoshi Murata, Gregor Körzdörfer, Josef Pfeuffer, Mathias Nittka, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 2 ) page: 141 - 146   2020.5

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    PURPOSE: It has been reported that leakage of intravenously administered gadolinium-based contrast agents (IV-GBCAs) into the cerebrospinal fluid (CSF) from the cortical veins even in healthy subjects can be detected using a highly sensitive pulse sequence such as heavily T2-weighted 3D fluid-attenuated inversion recovery and 3D-real inversion recovery (IR). The purpose of this study was to evaluate the feasibility of MR fingerprinting to detect GBCA leakage from the cortical veins after IV-GBCA. MATERIALS: Fourteen patients with suspected endolymphatic hydrops (EH) who received a single dose of IV-GBCA (39-79 years old) were included. The real IR images as well as MR fingerprinting images were obtained at 4 h after IV-GBCA. T1 and T2 values were obtained using MR fingerprinting and analyzed in ROIs covering intense GBCA leakage, and non-leakage areas of the CSF as determined on real IR images. The scan time for real IR imaging was 10 min and that for MR fingerprinting was 41 s. RESULTS: The mean T1 value of the ROI in the area of GBCA leakage was 2422 ± 261 ms and that in the non-leakage area was 3851 ± 235 ms (P < 0.01). There was no overlap between the T1 values in the area of GBCA leakage and those in the non-leakage area.The mean T2 value in the area of GBCA leakage was 319 ± 90 ms and that in the non-leakage area was 670 ± 166 ms (P < 0.01). There was some overlap between the T2 values in the area of GBCA leakage and those in the non-leakage area. CONCLUSION: Leaked GBCA from the cortical veins into the surrounding CSF can be detected using MR fingerprinting obtained in <1 min.

    DOI: 10.2463/mrms.mp.2019-0048

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  79. Unexpected radioactive iodine accumulation on whole-body scan after I-131 ablation therapy for differentiated thyroid cancer.

    Shingo Iwano, Shinji Ito, Shinichiro Kamiya, Rintaro Ito, Katsuhiko Kato, Shinji Naganawa

    Nagoya journal of medical science   Vol. 82 ( 2 ) page: 205 - 215   2020.5

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    We retrospectively evaluated the frequency of unexpected accumulation of radioactive iodine on the post-therapy whole-body scan (Rx-WBS) after radioactive iodine (RAI) ablation therapy in patients with differentiated thyroid cancer (DTC). We searched our institutional database for Rx-WBSs of DTC patients who underwent RAI ablation or adjuvant therapy between 2012 and 2019. Patients with distant metastasis diagnosed by CT or PET/CT before therapy, and those had previously received RAI therapy were excluded. In total, 293 patients (201 female and 92 male, median age 54 years) were selected. Two nuclear medicine physicians interpreted the Rx-WBS images by determining the visual intensity of radioiodine uptake by the thyroid bed, cervical and mediastinal lymph nodes, lungs, and bone. Clinical features of the patients with and without the metastatic accumulation were compared by chi-square test and median test. Logistic regression analyses were performed to compare the association between the presence of metastatic accumulation and these clinical factors. Eighty-four of 293 patients (28.7%) showed metastatic accumulation. Patients with metastatic RAI accumulation showed a significantly higher frequency of pathological N1 (pN1) and serum thyroglobulin (Tg) > 1.5 ng/ml under TSH stimulation (p = 0.035 and p = 0.031, respectively). Logistic regression analysis indicated that a serum Tg > 1.5 ng/ml was significantly correlated with the presence of metastatic accumulation (odds ratio = 1.985; p = 0.033). In conclusion, Patients with Tg > 1.5 ng/ml were more likely to show metastatic accumulation. In addition, the presence of lymph node metastasis at the initial thyroid surgery was also associated with this unexpected metastatic accumulation.

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  80. 特集 基礎から学ぶ肺癌診断  肺癌の3次元CT・PET/CT診断―原発巣の診断と悪性度― Reviewed

    岩野信吾、伊藤信嗣、伊藤倫太郎、神谷晋一朗、加藤克彦、長縄慎二

    画像診断   Vol. 40 ( 5 ) page: 439 - 446   2020.5

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  81. 150周年記念記事 高次医用科学 創基150周年に寄せて Reviewed

    長縄慎二

    名大医学部学友時報   Vol. 843 ( - ) page: 10 - 10   2020.4

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  82. Pharmacologic and non-pharmacologic interventions to prevent hypersensitivity reactions of non-ionic iodinated contrast media: a systematic review protocol.

    Umakoshi H, Nihashi T, Shimamoto H, Yamada T, Ishiguchi H, Takada A, Hirasawa N, Ishihara S, Takehara Y, Naganawa S, Davenport M, Terasawa T

    BMJ open   Vol. 10 ( 3 ) page: e033023   2020.3

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    DOI: 10.1136/bmjopen-2019-033023

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  83. Evaluation of newly implemented dose calculation algorithms for multileaf collimator-based CyberKnife tumor-tracking radiotherapy. Reviewed International journal

    Kohei Kawata, Takeshi Kamomae, Hiroshi Oguchi, Fumitaka Kawabata, Kuniyasu Okudaira, Mariko Kawamura, Kazuhiro Ohtakara, Yoshiyuki Itoh, Shinji Naganawa

    Medical physics   Vol. 47 ( 3 ) page: 1391 - 1403   2020.3

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    PURPOSE: In the previous treatment planning system (TPS) for CyberKnife (CK), multileaf collimator (MLC)-based treatment plans could be created only by using the finite-size pencil beam (FSPB) algorithm. Recently, a new TPS, including the FSPB with lateral scaling option (FSPB+) and Monte Carlo (MC) algorithms, was developed. In this study, we performed basic and clinical end-to-end evaluations for MLC-based CK tumor-tracking radiotherapy using the MC, FSPB+, and FSPB. METHODS: Water- and lung-equivalent slab phantoms were combined to obtain the percentage depth dose (PDD) and off-center ratio (OCR). The CK M6 system and Precision TPS were employed, and PDDs and OCRs calculated by the MC, FSPB+, and FSPB were compared with the measured doses obtained for 30.8 × 30.8 mm2 and 60.0 × 61.6 mm2 fields. A lung motion phantom was used for clinical evaluation and MLC-based treatment plans were created using the MC. The doses were subsequently recalculated using the FSPB+ and FSPB, while maintaining the irradiation parameters. The calculated doses were compared with the doses measured using a microchamber (for target doses) or a radiochromic film (for dose profiles). The dose volume histogram (DVH) indices were compared for all plans. RESULTS: In homogeneous and inhomogeneous phantom geometries, the PDDs calculated by the MC and FSPB+ agreed with the measurements within ±2.0% for the region between the surface and a depth of 250 mm, whereas the doses calculated by the FSPB in the lung-equivalent phantom region were noticeably higher than the measurements, and the maximum dose differences were 6.1% and 4.4% for the 30.8 × 30.8 mm2 and 60.0 × 61.6 mm2 fields, respectively. The maximum distance to agreement values of the MC, FSPB+, and FSPB at the penumbra regions of OCRs were 1.0, 0.6, and 1.1 mm, respectively, but the best agreement was obtained between the MC-calculated curve and measurements at the boundary of the water- and lung-equivalent slabs, compared with those of the FSPB+ and FSPB. For clinical evaluations using the lung motion phantom, under the static motion condition, the dose errors measured by the microchamber were -1.0%, -1.9%, and 8.8% for MC, FSPB+, and FSPB, respectively; their gamma pass rates for the 3%/2 mm criterion comparing to film measurement were 98.4%, 87.6%, and 31.4% respectively. Under respiratory motion conditions, there was no noticeable decline in the gamma pass rates. In the DVH indices, for most of the gross tumor volume and planning target volume, significant differences were observed between the MC and FSPB, and between the FSPB+ and FSPB. Furthermore, significant differences were observed for lung Dmean , V15 Gy , and V20 Gy between the MC, FSPB+, and FSPB. CONCLUSIONS: The results indicate that the doses calculated using the MC and FSPB+ differed remarkably in inhomogeneous regions, compared with the FSPB. Because the MC was the most consistent with the measurements, it is recommended for final dose calculations in inhomogeneous regions such as the lung. Furthermore, the sufficient accuracy of dose delivery using MLC-based tumor-tracking radiotherapy by CK was demonstrated for clinical implementation.

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  84. 磁気共鳴画像によるNeurofluids動態の解明 Reviewed

    長縄慎二、田岡俊昭、川井 恒

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 令和元年度活動報告書   Vol. - ( - ) page: 30 - 30   2020.3

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  85. 脳動脈瘤破裂リスク評価のための磁気共鳴流体解析と計算流体解析による形態ならびに血流動態バイオマーカーの検討 Reviewed

    MAJUWANA GAMAGE, 礒田治夫、泉 孝嗣、若林俊彦、長縄慎二

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 令和元年度活動報告書   Vol. - ( - ) page: 27 - 27   2020.3

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  86. The Space between the Pial Sheath and the Cortical Venous Wall May Connect to the Meningeal Lymphatics. Reviewed

    Shinji Naganawa, Rintaro Ito, Toshiaki Taoka, Tadao Yoshida, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 19 ( 1 ) page: 1 - 4   2020.2

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    We currently obtain pre- and post-contrast enhanced whole brain 3D-real inversion recovery images for the evaluation of endolymphatic hydrops. We noticed that the space between the pial sheath surrounding the cortical veins and the cortical venous wall is enhanced and this enhancement seems to connect to the meningeal lymphatics along superior sagittal sinus. This new anatomical concept regarding the outflow from the glymphatic system might be important for the future research in neuroscience.

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  87. Kinetic volume analysis on dynamic contrast-enhanced MRI of triple-negative breast cancer: associations with survival outcomes. Reviewed International journal

    Yoko Hayashi, Hiroko Satake, Satoko Ishigaki, Rintaro Ito, Mariko Kawamura, Hisashi Kawai, Shingo Iwano, Shinji Naganawa

    The British journal of radiology   Vol. 93 ( 1106 ) page: 20190712 - 20190712   2020.2

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    OBJECTIVE: To evaluate the associations between computer-aided diagnosis (CAD)-generated kinetic volume parameters and survival in triple-negative breast cancer (TNBC) patients. METHODS: 40 patients with TNBC who underwent pre-operative MRI between March 2008 and March 2014 were included. We analyzed CAD-generated parameters on dynamic contrast-enhanced MRI, visual MRI assessment, and histopathological data. Cox proportional hazards models were used to determine associations with survival outcomes. RESULTS: 12 of the 40 (30.0%) patients experienced recurrence and 7 died of breast cancer after a median follow-up of 73.6 months. In multivariate analysis, higher percentage volume (%V) with more than 200% initial enhancement rate correlated with worse disease-specific survival (hazard ratio, 1.12; 95% confidence interval, 1.02-1.22; p-value, 0.014) and higher %V with more than 100% initial enhancement rate followed by persistent curve type at 30% threshold correlated with worse disease-specific survival (hazard ratio, 1.33; 95% confidence interval, 1.10-1.61; p-value, 0.004) and disease-free survival (hazard ratio, 1.27; 95% confidence interval, 1.12-1.43; p-value, 0.000). CONCLUSION: CAD-generated kinetic volume parameters may correlate with survival in TNBC patients. Further study would be necessary to validate our results on larger cohorts. ADVANCES IN KNOWLEDGE: CAD generated kinetic volume parameters on breast MRI can predict recurrence and survival outcome of patients in TNBC. Varying the enhancement threshold improved the predictive performance of CAD generated kinetic volume parameter.

    DOI: 10.1259/bjr.20190712

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  88. White matter microstructural changes in tuberous sclerosis: Evaluation by neurite orientation dispersion and density imaging (NODDI) and diffusion tensor images. Reviewed International journal

    Toshiaki Taoka, Noriko Aida, Yuta Fujii, Kazushi Ichikawa, Hisashi Kawai, Toshiki Nakane, Rintaro Ito, Shinji Naganawa

    Scientific reports   Vol. 10 ( 1 ) page: 436 - 436   2020.1

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    Neurite orientation dispersion and density imaging (NODDI) is a novel diffusion method for evaluating tissue microstructure, and may provide additional information over conventional diffusion tensor imaging (DTI). We evaluated NODDI and DTI parameters in cases of tuberous sclerosis (TS) to assess microstructural changes in the white matter. Eleven cases of tuberous sclerosis and eight age-matched controls underwent NODDI and DTI. We performed qualitative analysis and tract-based spatial statistics (TBSS) analysis of the NODDI parameters (Ficv: intracellular volume fraction, Fiso: isotropic fraction, ODI: orientation dispersion index) as well as DTI parameters (MD: mean diffusivity, FA: fractional anisotropy). We also performed a correlation analysis between clinical symptoms and parameters. The qualitative analysis indicated that the Ficv had a lower value in TS cases particularly in the tubers adjacent to the white matter. The TBSS analysis showed that the TS cases had decreased Ficv in a greater area compared to the other parameters including MD. In particular, the Ficv was decreased in deep white matter, such as the superior longitudinal fascicles (SLF). The application of NODDI to TS cases revealed tissue microstructural changes, and particularly the Ficv could detect more widespread abnormalities in white matter structure compared to DTI parameters.

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  89. Glymphatic imaging using MRI. Reviewed International journal

    Toshiaki Taoka, Shinji Naganawa

    Journal of magnetic resonance imaging : JMRI   Vol. 51 ( 1 ) page: 11 - 24   2020.1

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    In recent years, the existence of a mass transport system in the brain via cerebrospinal fluid (CSF) or interstitial fluid (ISF) has been suggested by many studies. The glymphatic system is hypothesized to be a waste clearance system of the CSF through the perivascular and interstitial spaces in the brain. Tracer studies have primarily been used to visualize or evaluate the waste clearance system in the brain, and evidence for this system has accumulated. The initial study that identified the glymphatic system was an in vivo tracer study in mice. In that study, fluorescent tracers were injected into the cisterna magna and visualized by two-photon microscopy. MRI has also been used to evaluate glymphatic function primarily with gadolinium-based contrast agents (GBCAs) as tracers. A number of GBCA studies evaluating glymphatic function have been conducted using either intrathecal or intravenous injections. Stable isotopes, such as 17 O-labeled water, may also be used as tracers since they can be detected by MRI. In addition to tracer studies, several other approaches have been used to evaluate ISF dynamics within the brain, including diffusion imaging. Phase contrast evaluation is a powerful method for visualizing flow within the CSF space. In order to evaluate the movement of water within tissue, diffusion-weighted MRI represents another promising technique, and several studies have utilized diffusion techniques for the evaluation of the glymphatic system. This review will discuss the findings of these diffusion studies. Level of Evidence: 5 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2020;51:11-24.

    DOI: 10.1002/jmri.26892

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  90. Celebrating the beginning of international journal collaboration. Reviewed

    Shinji Naganawa, Yukunori Korogi

    Japanese journal of radiology   Vol. 38 ( 1 ) page: 1 - 2   2020.1

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    DOI: 10.1007/s11604-019-00904-5

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  91. Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks. International journal

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshiaki Taoka, Shuji Koyama, Hiroki C Tanabe, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue

    Frontiers in aging neuroscience   Vol. 12   page: 592469 - 592469   2020

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    Recent studies have demonstrated that connector hubs, regions considered critical for the flow of information across neural systems, are mostly involved in neurodegenerative dementia. Considering that aging can significantly affect the brain's intrinsic connectivity, identifying aging's impact on these regions' overall connection strength is important to differentiate changes associated with healthy aging from neurodegenerative disorders. Using resting state functional magnetic resonance imaging data from a carefully selected cohort of 175 healthy volunteers aging from 21 to 86 years old, we computed an intrinsic connectivity contrast (ICC) metric, which quantifies a region's overall connectivity strength, for whole brain, short-range, and long-range connections and examined age-related changes of this metric over the adult lifespan. We have identified a limited number of hub regions with ICC values that showed significant negative relationship with age. These include the medial precentral/midcingulate gyri and insula with both their short-range and long-range (and thus whole-brain) ICC values negatively associated with age, and the angular, middle frontal, and posterior cingulate gyri with their long-range ICC values mainly involved. Seed-based connectivity analyses further confirmed that these regions are connector hubs with connectivity profile that strongly overlapped with multiple large-scale brain networks. General cognitive performance was not associated with these hubs' ICC values. These findings suggest that even healthy aging could negatively impact the efficiency of regions critical for facilitating information transfer among different functional brain networks. The extent of the regions involved, however, was limited.

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  92. Assessment of Severity in Chronic Thromboembolic Pulmonary Hypertension by Quantitative Parameters of Dual-Energy Computed Tomography

    Tsutsumi Yoshinori, Iwano Shingo, Okumura Naoki, Adachi Shiro, Abe Shinji, Kondo Takahisa, Kato Katsuhiko, Naganawa Shinji

    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY   Vol. 44 ( 4 ) page: 578 - 585   2020

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    DOI: 10.1097/RCT.0000000000001052

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  93. A phase I/II trial of intraoperative breast radiotherapy in an Asian population: 10-year results

    Kawamura M., Yoshiyuki I., Kamomae T., Ito J., Oie Y., Ohtakara K., Naganawa S.

    RADIOTHERAPY AND ONCOLOGY   Vol. 141   page: S61 - S61   2019.12

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  94. 2020年 最新医療機器の現状と展望 CTおよびMRIなどの画像診断装置の今後の在り方と展望 Reviewed

    長縄慎二

    月刊新医療データブック・シリーズ 医療機器システム白書   Vol. - ( - ) page: 12 - 15   2019.12

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  95. 私と医療 New Med Essay ―第176回 動機はいい加減だったものの、真面目に取り組めばこそ― Reviewed

    長縄慎二

    月刊新医療   Vol. 540 ( - ) page: 77 - 77   2019.11

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  96. Balloon-Occluded Retrograde Transvenous Obliteration for Fundal Gastric Variceal Bleeding in a Small Child. Reviewed International journal

    Tomohiro Komada, Kojiro Suzuki, Kazuo Oshima, Masaya Matsushima, Ken Nagasaka, Shinji Naganawa

    Journal of vascular and interventional radiology : JVIR   Vol. 30 ( 10 ) page: 1624 - 1625   2019.10

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    DOI: 10.1016/j.jvir.2019.06.022

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  97. ちょっと気になる胆・膵画像 ティーチングファイルから(第43回) 術前診断が困難であった膵lymphangiomaの1例

    小川 浩, 竹原 康雄, 長縄 慎二, 高見 秀樹, 中黒 匡人

    胆と膵   Vol. 40 ( 10 ) page: 841 - 844   2019.10

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  98. ちょっと気になる胆・膵画像―ティ-チングファイルから―(第43回) 術前診断が困難であった膵Iymphangiomaの1例 Reviewed

    小川 浩、竹原康雄、長縄慎二、高見秀樹、中黒匡人

    胆と膵   Vol. 40 ( 10 ) page: 841 - 844   2019.10

  99. Glymphatic systemとMRI―ヒトでの可視化に向けた取り組み Reviewed

    長縄慎二

    医学のあゆみ   Vol. 270 ( 13 ) page: 1189 - 1192   2019.10

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  100. Should Small Cell Carcinoma of the Cervix be Treated As Localized Small Cell Cancer or Advanced Cervical Cancer: A Retrospective Multi-Institutional Cohort Study

    Kawamura M., Koide Y., Murai T., Ishihara S., Takase Y., Murao T., Okazaki D., Yamaguchi T., Uchiyama K., Itoh Y., Kodaira T., Shibamoto Y., Mizuno M., Kikkawa F., Naganawa S.

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   Vol. 105 ( 1 ) page: E324-E325   2019.9

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  101. Clinical Results of T1 Glottic Cancer Treated with Radiotherapy Using 2.25 Gy per Fractions: A Multicenter Survey in Clinical Practice

    Oie Y., Itoh Y., Kawamura M., Takase Y., Murao T., Ishihara S., Nomoto Y., Hirasawa N., Asano A., Yamakawa K., Ito J., Naganawa S.

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   Vol. 105 ( 1 ) page: E366-E367   2019.9

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  102. Reorganization of brain networks and its association with general cognitive performance over the adult lifespan. Reviewed International journal

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshiaki Taoka, Shuji Koyama, Hiroki C Tanabe, Masahisa Katsuno, Toshihiko Wakabayashi, Masafumi Kuzuya, Norio Ozaki, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Gen Sobue

    Scientific reports   Vol. 9 ( 1 ) page: 11352 - 11352   2019.8

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    Healthy aging is associated with structural and functional changes in the brain even in individuals who are free of neurodegenerative diseases. Using resting state functional magnetic resonance imaging data from a carefully selected cohort of participants, we examined cross sectional changes in the functional organization of several large-scale brain networks over the adult lifespan and its potential association with general cognitive performance. Converging results from multiple analyses at the voxel, node, and network levels showed widespread reorganization of functional brain networks with increasing age. Specifically, the primary processing (visual and sensorimotor) and visuospatial (dorsal attention) networks showed diminished network integrity, while the so-called core neurocognitive (executive control, salience, and default mode) and basal ganglia networks exhibited relatively preserved between-network connections. The visuospatial and precuneus networks also showed significantly more widespread increased connectivity with other networks. Graph analysis suggested that this reorganization progressed towards a more integrated network topology. General cognitive performance, assessed by Addenbrooke's Cognitive Examination-Revised total score, was positively correlated with between-network connectivity among the core neurocognitive and basal ganglia networks and the integrity of the primary processing and visuospatial networks. Mediation analyses further indicated that the observed association between aging and relative decline in cognitive performance could be mediated by changes in relevant functional connectivity measures. Overall, these findings provided further evidence supporting widespread age-related brain network reorganization and its potential association with general cognitive performance during healthy aging.

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  103. Whole abdominopelvic intensity-modulated radiation therapy for peritoneal disseminated rhabdomyosarcoma with three-year follow-up: a case report. Reviewed International journal

    Mariko Kawamura, Kuniyasu Okudaira, Yoshiyuki Itoh, Takeshi Kamomae, Eri Nishikawa, Hideki Muramatsu, Yoshiyuki Takahashi, Kazuki Yokota, Shinji Naganawa

    Radiation oncology (London, England)   Vol. 14 ( 1 ) page: 127 - 127   2019.7

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    BACKGROUND: The role of local radiotherapy in the treatment of metastatic rhabdomyosarcoma is important. However, with peritoneal dissemination, the application of local therapy is challenging. Although there are few reports addressing the efficacy of the whole abdominopelvic irradiation to peritoneal disseminated rhabdomyosarcoma patients, no precise curse of treatment nor the follow up result is explained in paper nor in the text. CASE PRESENTATION: Six years old rhabdomyosarcoma boy with peritoneal dissemination was treated at our facility under COG D9803 protocol (vincristine, dactinomycin, and cyclophosphamide (VAC)). He underwent tumor resection on the 14th week according to the protocol. During surgery, the 2-cm residual tumor was completely resected, but in the pelvis, numerous nodules that were suspected as peritoneal disseminated tumors were observed. We administered 30 Gy/20fr whole abdominopelvic radiotherapy using volumetric modulated arc therapy (VMAT) technique and a 6 Gy sequential boost to pelvis after the surgery and completed the protocol treatment. During the course of treatment, the patient experienced G4 hematological toxicity and received multiple transfusions, particularly after whole abdominopelvic irradiation. He has achieved complete remission and is alive without evidence of recurrence and severe late adverse effect for 3 years. In terms of growth, his height and weight are within the average values for Japanese boys at the same age. CONCLUSION: By using the VMAT technique, a patient with peritoneal disseminated rhabdomyosarcoma can be treated, and a dose of 30 Gy to the whole abdominopelvis with concurrent chemotherapy may be tolerable.

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  104. 2.胸部領域 胸部画像診断におけるAIと臨床研究について Reviewed

    伊藤倫太郎、岩野信吾、長縄慎二

    INNERVISION   Vol. 34 ( 7 ) page: 25 - 28   2019.7

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  105. Postoperative recurrence of clinical early-stage non-small cell lung cancers: a comparison between solid and subsolid nodules. Reviewed International journal

    Shingo Iwano, Hiroyasu Umakoshi, Shinichiro Kamiya, Kohei Yokoi, Koji Kawaguchi, Takayuki Fukui, Shinji Naganawa

    Cancer imaging : the official publication of the International Cancer Imaging Society   Vol. 19 ( 1 ) page: 33 - 33   2019.6

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    BACKGROUND: For subsolid non-small cell lung cancers (NSCLCs), solid size (SS), which is the maximal diameter of the solid component, correlates more accurately with tumor prognosis than the total size, which is the maximal diameter of the entire tumor, including ground-glass opacity. We reviewed the propriety of the TNM staging based on the SS for early-stage NSCLCs. METHODS: We retrospectively reviewed the preoperative radiological reports, clinical records, and pathological reports of NSCLC cases in our hospital between 2010 and 2013, and clinical stage (c-Stage) 0 and I tumors were selected. Disease-free survival (DFS), based on survival analysis, was used to assess the tumor characteristics that predicted the prognosis. RESULTS: A total of 247 NSCLC diagnoses in 231 patients (88 women and 143 men; age, 67 ± 7 years) were included in our cohort. They were classified into solid (n = 131) and subsolid (n = 116) nodules. The DFS curves indicated that prognosis was significantly worse in the following order: c-Stage 0, c-Stage IA, and c-Stage IB tumors (p = 0.016). Patients with solid nodules showed a significantly worse prognosis than patients with subsolid nodules (p < 0.001). A multivariate Cox proportional hazards model showed that the significant predictive factors for DFS were c-Stage (hazard ratio, 1.600; p = 0.020) and solid nodules (hazard ratio, 3.077; p = 0.031). CONCLUSIONS: For early-stage NSCLCs, the c-Stage based on the SS in subsolid nodules was useful for predicting postoperative DFS. In addition, whether nodules were solid or subsolid was another independent prognostic factor.

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  106. A plea for systematic literature analysis and conclusive study design, comment on: "Systematic review of magnetic resonance imaging for diagnosis of Meniere disease". Reviewed International journal

    Robert Gürkov, Krisztina Barath, Bert de Foer, Munehisa Fukushima, Michael Gluth, Jermy Hornibrook, Nicolas Perez-Fernandez, Ilmari Pyykkö, Michihiko Sone, Shin-Ichi Usami, Wuqing Wang, Jing Zou, Shinji Naganawa

    Journal of vestibular research : equilibrium & orientation     2019.6

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    DOI: 10.3233/VES-190662

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  107. Monitoring of fatigue in radiologists during prolonged image interpretation using fNIRS. Reviewed

    Takashi Nihashi, Takeo Ishigaki, Hiroko Satake, Shinji Ito, Osamu Kaii, Yoshine Mori, Kazuhiro Shimamoto, Hiromichi Fukushima, Kojiro Suzuki, Hiroyasu Umakoshi, Mitsuo Ohashi, Fumio Kawaguchi, Shinji Naganawa

    Japanese journal of radiology   Vol. 37 ( 6 ) page: 437 - 448   2019.6

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    PURPOSE: To determine whether functional near-infrared spectroscopy (fNIRS) allows monitoring fatigue in radiologists during prolonged image interpretation. MATERIALS AND METHODS: Nine radiologists participated as subjects in the present study and continuously interpreted medical images and generated reports for cases for more than 4 h under real clinical work conditions. We measured changes in oxygenated hemoglobin concentrations [oxy-Hb] in the prefrontal cortex using 16-channel fNIRS (OEG16ME, Spectratech) every hour during the Stroop task to evaluate fatigue of radiologists and recorded fatigue scale (FS) as a behavior data. RESULTS: Two subjects showed a subjective feeling of fatigue and an apparent decrease in brain activity after 4 h, so the experiment was completed in 4 h. The remaining seven subjects continued the experiment up to 5 h. FS decreased with time, and a significant reduction was observed between before and the end of image interpretation. Seven out of nine subjects showed a minimum [oxy-Hb] change at the end of prolonged image interpretation. The mean change of [oxy-Hb] at the end of all nine subjects was significantly less than the maximum during image interpretation. CONCLUSION: fNIRS using the change of [oxy-Hb] may be useful for monitoring fatigue in radiologists during image interpretation.

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  108. 食道平滑筋腫 Reviewed

    兵藤良太、岩野信吾、長縄慎二

    画像診断   Vol. 39 ( 7 ) page: 662 - 663   2019.6

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  109. Increased signal intensity of low-concentration gadolinium contrast agent by longer repetition time in heavily T<sub>2</sub>-weighted-3D-FLAIR.

    Kato Y, Bokura K, Taoka T, Naganawa S

    Japanese journal of radiology   Vol. 37 ( 5 ) page: 431-435   2019.5

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    DOI: 10.1007/s11604-019-00828-0

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  110. Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study. Reviewed

    Nao Takano, Suguru Yamada, Akihiro Hirakawa, Yukihiro Yokoyama, Hiroki Kawashima, Osamu Maeda, Tohru Okada, Eizaburo Ohno, Junpei Yamaguchi, Takuya Ishikawa, Fuminori Sonohara, Masaya Suenaga, Hideki Takami, Masamichi Hayashi, Yukiko Niwa, Yoshiki Hirooka, Yoshiyuki Ito, Shinji Naganawa, Yuichi Ando, Masato Nagino, Hidemi Goto, Tsutomu Fujii, Yasuhiro Kodera

    Nagoya journal of medical science   Vol. 81 ( 2 ) page: 233 - 239   2019.5

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    The efficacy of nab-paclitaxel combined with gemcitabine (GnP) and of chemoradiotherapy (CRT) for unresectable locally advanced pancreatic ductal adenocarcinoma (UR-LA PDAC) is still unclear. We previously conducted a phase I study of CRT using GnP and determined the recommended dose and have now designed a phase II trial to evaluate the efficacy of CRT incorporating GnP for UR-LA PDAC. Eligibility criteria are chemotherapy-naïve patients with UR-LA PDAC as defined by the NCCN guidelines version 2. 2016. Study patients will receive 100 mg/m2 nab-paclitaxel and 800 mg/m2 gemcitabine on Days 1, 8, and 15 per 4-week cycle with concurrent radiation therapy (total dose of 50.4 Gy in 28 fractions of 1.8 Gy per day, 5 days per week). Treatment will be continued until disease progression or surgery, which is to be performed only for patients in whom the disease is well-controlled at 8 months from beginning the protocol treatment. Primary endpoint is 2-year overall survival rate and co-primary endpoint is resection rate. Secondary endpoints are overall survival, progression free survival, time to treatment failure, response rate, disease control rate, early tumor shrinkage, depth of response, reduction of SUV-max on PET-CT, serum tumor markers, relative dose intensity, safety, and Quality of life. This study will show the efficacy and safety of chemoradiotherapy combined with GnP.

    DOI: 10.18999/nagjms.81.2.233

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  111. 子宮平滑筋肉腫 Reviewed

    櫻井悠介、岩野信吾、長縄慎二、下山芳江、新美 薫

    画像診断   Vol. 39 ( 6 ) page: 512 - 513   2019.5

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  112. Utility of Metabolic Parameters on FDG PET/CT in the Classification of Early-Stage Lung Adenocarcinoma: Prediction of Pathological Invasive Size.

    Iwano S, Ito S, Kamiya S, Ito R, Kato K, Naganawa S

    Clinical nuclear medicine     2019.4

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    DOI: 10.1097/RLU.0000000000002591

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  113. A case of human pancreatic eurytremiasis. Reviewed International journal

    Hiroshi Ogawa, Yasuo Takehara, Shinji Naganawa, Junpei Yamaguchi, Masato Nakaguro

    Abdominal radiology (New York)   Vol. 44 ( 4 ) page: 1213 - 1216   2019.4

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    This study provides the first comprehensive imaging report of human pancreatic eurytremiasis. A 43-year-old man with obstructive jaundice and a pancreatic tumor was referred for diagnosis and treatment. Serum aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase were elevated. Computed tomography (CT) revealed a multilocular cystic lesion with delayed enhanced area in the pancreas head. On magnetic resonance imaging, the tumor was hyperintense on diffusion-weighted image, and the apparent diffusion coefficient value of the tumor was lower than that of the normal pancreatic parenchyma. Positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose integrated with computed tomography (18F-FDG PET/CT) revealed abnormally increased uptake of 18F-FDG in the tumor. A subtotal stomach-preserving pancreaticoduodenectomy was performed on the preoperative diagnosis of pancreatic carcinoma accompanied by branch duct-type intraductal papillary mucinous neoplasm. Multifocal granulomatous lesions with necrotic areas including many parasite eggs were seen on the histology. The final diagnosis was pancreatic eurytremiasis.

    DOI: 10.1007/s00261-019-01925-4

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  114. Clinical Features of Ears With Otosclerosis and Endolymphatic Hydrops.

    Wang F, Yoshida T, Sugimoto S, Shimono M, Teranishi M, Naganawa S, Sone M

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   Vol. 40 ( 4 ) page: 441-445   2019.4

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    DOI: 10.1097/MAO.0000000000002175

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  115. Influence of implanted metals in new CT reconstruction algorithm for radiotherapy treatment planning

    Kamomae T, Nakaya T, Kawabata F, Okudaira K, Kumagai M, Oguchi H, Itoh Y, Naganawa S

    RADIOTHERAPY AND ONCOLOGY   Vol. 133   page: S1132-S1132   2019.4

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  116. 縦隔奇形腫 Reviewed

    中根俊樹、岩野信吾、長縄慎二

    画像診断   Vol. 39 ( 5 ) page: 380 - 381   2019.4

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  117. 7テスラMR装置における高空間分解能3次元位相コントラスト磁気共鳴法を利用した脳血流動態解析の制度検証 Reviewed

    田嶋駿亮、礒田治夫、福永雅喜、長縄慎二

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 平成30年度活動報告書   Vol. - ( - ) page: 24 - 24   2019.3

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  118. 腎静脈に発生した平滑筋肉腫 Invited Reviewed

    松島正哉、林 葉子、岩野信吾、長縄慎二、下山芳江

    画像診断   Vol. 39 ( 3 ) page: 252 - 253   2019.3

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  119. 脳とこころの研究センター長 挨拶 Reviewed

    長縄慎二

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 平成30年度活動報告書   Vol. - ( - ) page: 1 - 1   2019.3

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  120. MRによる血液-脳間質液-脳脊髄液の動態の解明 Reviewed

    長縄慎二、田岡俊昭、川井 恒

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 平成30年度活動報告書   Vol. - ( - ) page: 29 - 30   2019.3

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  121. Quantitative Follow-Up Assessment of Patients with Interstitial Lung Disease by 3D-Curved High-Resolution CT Imaging Parallel to the Chest Wall. Reviewed

    Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Keigo Nakamura, Shinji Naganawa

    Nagoya journal of medical science   Vol. 81 ( 1 ) page: 41 - 53   2019.2

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    We evaluated the progression of interstitial lung disease (ILD) by three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall and compare the results to pulmonary function test (PFT) results on a follow-up assessment. We reviewed the patients with ILD who underwent HRCT and concurrent PFTs at least twice from April 2008 to December 2014. Forty-five patients with ILD were enrolled. 3D-cHRCT images of the lung at various depths from the chest wall were reconstructed, and total area (TA), high-attenuation area (HAA) >-500 HU, and %HAA ([HAA/TA] × 100) were calculated. The TA, HAA, and %HAA ratios (follow-up to baseline) were assessed for use in the diagnosis of physiologically progressive ILD (defined as; forced vital capacity [FVC] ratio <0.9 or %diffusing capacity of the lung for carbon monoxide [%DLCO] ratio <0.85 [follow-up to baseline]). Of all ratios obtained from 3D-cHRCT images at 5-30mm depths, the %HAA ratio at 20-mm had the largest area under the receiver operating characteristic curve (0.815, 95 % confidence interval 0.677-0.953). By univariate logistic regression analysis, TA, HAA, and %HAA ratios at 20-mm showed significant correlations with physiologically progressive ILD. 3D-cHRCT imaging performed in parallel with the chest wall offers novel quantitative parameters that are useful for following ILD.

    DOI: 10.18999/nagjms.81.1.41

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  122. パーキンソン病におけるdefault mode network Reviewed

    渡辺宏久、勝野雅央、長縄慎二、祖父江元

    CLINICAL NEUROSCIENCE (月間 臨床神経科学)   Vol. 37 ( 2 ) page: 212 - 216   2019.2

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  123. 膵上皮内腫瘍性病変 Reviewed

    小川 浩、岩野信吾、長縄慎二、中黒匡人

    画像診断   Vol. 39 ( 2 ) page: 142 - 143   2019.2

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  124. Significance of internal auditory canal diverticula in ears with otosclerosis.

    Wang F, Yoshida T, Shimono M, Sugimoto S, Teranishi M, Naganawa S, Sone M

    Acta oto-laryngologica     page: 1-4   2019.1

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    DOI: 10.1080/00016489.2018.1521526

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  125. 画像診断と病理 骨芽細胞腫 Reviewed

    駒田智大、岩野信吾、長縄慎二

    画像診断   Vol. 39 ( 1 ) page: 4 - 5   2019.1

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  126. 画像診断と病理 骨芽細胞腫

    駒田 智大, 岩野 信吾, 長縄 慎二, 新井 英介, 西田 佳弘, 下山 芳江

    画像診断   Vol. 39 ( 1 ) page: 4-5 - 5   2018.12

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  127. Signal Intensity of the Cerebrospinal Fluid after Intravenous Administration of Gadolinium-based Contrast Agents: Strong Contrast Enhancement around the Vein of Labbe.

    Ohashi T, Naganawa S, Ogawa E, Katagiri T, Kuno K

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2018.11

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    DOI: 10.2463/mrms.mp.2018-0043

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  128. Can low b value diffusion weighted imaging evaluate the character of cerebrospinal fluid dynamics?

    Taoka T, Naganawa S, Kawai H, Nakane T, Murata K

    Japanese journal of radiology     2018.11

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    DOI: 10.1007/s11604-018-0790-8

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  129. Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging.

    Naganawa S, Nakane T, Kawai H, Taoka T

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2018.11

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    DOI: 10.2463/mrms.mp.2018-0053

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  130. 画像診断レポート未読問題について

    長縄慎二

    健康文化   ( 53 ) page: 138-142   2018.11

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  131. 第三次人工知能ブーム?

    長縄慎二

    健康文化   ( 53 ) page: 1-2   2018.11

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  132. 2019年 最新医療機器の動向を探る CTおよびMRIなどの画像診断機器の最新潮流ならびに今後のあり方

    長縄慎二

    医療機器システム白書     page: 14-17   2018.11

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  133. Analysis of late adverse events and their chronological changes after radiation therapy for cervical cancer

    Yamada Takehiro, Ishihara Shunichi, Kawai Michiyasu, Itoh Yoshiyuki, Naganawa Shinji, Ikeda Mitsuru

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 4 ) page: 487-496   2018.11

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    DOI: 10.18999/nagjms.80.4.487

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  134. 画像診断レポート未読問題について Reviewed

    長縄慎二

    健康文化   Vol. 53 ( - ) page: 138 - 142   2018.11

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  135. 第三次人工知能ブーム? Reviewed

    長縄慎二

    健康文化   Vol. 53 ( - ) page: 1 - 2   2018.11

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  136. Significance of Endolymphatic Hydrops Herniation Into the Semicircular Canals Detected on MRI.

    Sugimoto S, Yoshida T, Teranishi M, Kobayashi M, Shimono M, Naganawa S, Sone M

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   Vol. 39 ( 10 ) page: 1229-1234   2018.10

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    DOI: 10.1097/MAO.0000000000002022

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  137. Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer's Disease: A PET (THK5351, PiB) and Resting fMRI Study. Reviewed International journal

    Takamasa Yokoi, Hirohisa Watanabe, Hiroshi Yamaguchi, Epifanio Bagarinao, Michihito Masuda, Kazunori Imai, Aya Ogura, Reiko Ohdake, Kazuya Kawabata, Kazuhiro Hara, Yuichi Riku, Shinsuke Ishigaki, Masahisa Katsuno, Shinichi Miyao, Katsuhiko Kato, Shinji Naganawa, Ryuichi Harada, Nobuyuki Okamura, Kazuhiko Yanai, Mari Yoshida, Gen Sobue

    Frontiers in aging neuroscience   Vol. 10   page: 304 - 304   2018.10

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    Background: Imaging studies in Alzheimer's disease (AD) have yet to answer the underlying questions concerning the relationship among tau retention, neuroinflammation, network disruption and cognitive decline. We compared the spatial retention patterns of 18F-THK5351 and resting state network (RSN) disruption in patients with early AD and healthy controls. Methods: We enrolled 23 11C-Pittsburgh compound B (PiB)-positive patients with early AD and 24 11C-PiB-negative participants as healthy controls. All participants underwent resting state functional MRI and 18F-THK5351 PET scans. We used scaled subprofile modeling/principal component analysis (SSM/PCA) to reduce the complexity of multivariate data and to identify patterns that exhibited the largest statistical effects (variances) in THK5351 concentration in AD and healthy controls. Findings: SSM/PCA identified a significant spatial THK5351 pattern composed by mainly three clusters including precuneus/posterior cingulate cortex (PCC), right and left dorsolateral prefrontal cortex (DLPFC) which accounted for 23.6% of the total subject voxel variance of the data and had 82.6% sensitivity and 79.1% specificity in discriminating AD from healthy controls. There was a significant relationship between the intensity of the 18F-THK5351 covariation pattern and cognitive scores in AD. The spatial patterns of 18F-THK5351 uptake showed significant similarity with intrinsic functional connectivity, especially in the PCC network. Seed-based connectivity analysis from the PCC showed significant decrease in connectivity over widespread brain regions in AD patients. An evaluation of an autopsied AD patient with Braak V showed that 18F-THK5351 retention corresponded to tau deposition, monoamine oxidase-B (MAO-B) and astrogliosis in the precuneus/PCC. Interpretation: We identified an AD-specific spatial pattern of 18F-THK5351 retention in the precuneus/PCC, an important connectivity hub region in the brain. Disruption of the functional connections of this important network hub may play an important role in developing dementia in AD.

    DOI: 10.3389/fnagi.2018.00304

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  138. Diagnostic Radiology Service in Japan. Reviewed

    Shinji Naganawa, Yukunori Korogi

    Japanese journal of radiology   Vol. 36 ( 10 ) page: 575 - 578   2018.10

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    DOI: 10.1007/s11604-018-0770-z

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  139. PREDICTION OF INTRACRANIAL ARTERIAL STENOSIS PROGRESSION IN PATIENTS WITH MOYAMOYA VASCULOPATHY: CONTRAST-ENHANCED HIGH-RESOLUTION MAGNETIC RESONANCE VESSELWALL IMAGING

    Muraoka S., Araki Y., Taoka T., Kawai H., Okamoto S., Uda K., Ota S., Naganawa S., Wakabayashi T.

    INTERNATIONAL JOURNAL OF STROKE   Vol. 13   page: 32-32   2018.10

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  140. Longitudinal Findings of MRI and PET in West Syndrome with Subtle Focal Cortical Dysplasia

    Sakaguchi Y., Kidokoro H., Ogawa C., Okai Y., Ito Y., Yamamoto H., Ohno A., Nakata T., Tsuji T., Nakane T., Kawai H., Kato K., Naganawa S., Natsume J.

    AMERICAN JOURNAL OF NEURORADIOLOGY   Vol. 39 ( 10 ) page: 1932-1937   2018.10

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    DOI: 10.3174/ajnr.A5772

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  141. Prediction of recurrence using volume-based metabolic index obtained by preoperative FDG-PET for non-small-cell lung cancer

    Ito S., Iwano S., Kato K., Naganawa S.

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   Vol. 45   page: S506-S506   2018.10

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  142. Histogram analysis of quantitative pharmacokinetic parameters on DCE-MRI: correlations with prognostic factors and molecular subtypes in breast cancer.

    Nagasaka K, Satake H, Ishigaki S, Kawai H, Naganawa S

    Breast cancer (Tokyo, Japan)     2018.8

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    DOI: 10.1007/s12282-018-0899-8

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  143. Prediction of Intracranial Arterial Stenosis Progression in Patients with Moyamoya Vasculopathy: Contrast-Enhanced High-Resolution Magnetic Resonance Vessel Wall Imaging. Reviewed International journal

    Shinsuke Muraoka, Yoshio Araki, Toshiaki Taoka, Hisashi Kawai, Sho Okamoto, Kenji Uda, Shinji Ota, Shinji Naganawa, Toshihiko Wakabayashi

    World neurosurgery   Vol. 116   page: e1114-e1121 - e1121   2018.8

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    OBJECTIVE: Moyamoya vasculopathy (MMV) is characterized by progressive stenosis of the intracranial arteries. MMV currently has no curative treatments, and cerebral ischemia and hemorrhage are the major outcomes. Evaluation of the stroke risk of each patient resulting from the progression of intracranial arterial stenosis is clinically important. METHODS: We prospectively reviewed patients with intracranial arterial stenosis and already diagnosed MMV. High-resolution magnetic resonance imaging using contrast agent is the novel vessel wall imaging (VWI) technique for directly evaluating vascular walls and intracranial artery disease. All patients underwent high-resolution vessel wall imaging and magnetic resonance angiography at the time of registration, and they underwent follow-up magnetic resonance angiography. The Fisher exact test was used to assess associations between the degrees of wall enhancement and between stable and progressive intracranial arterial stenosis. RESULTS: A total of 24 patients (17 female; mean age, 36.1 ± 16.8 years; range 3-67 years) with MMV were consecutively recruited to this study. Progression of stenosis was shown in 6 lesions (66.6%) on strong enhancement, 2 lesions (12.5%) on mild enhancement, and 1 lesion (4.3%) on lack of enhancement. Arterial vessel wall enhancement in MMV patients correlated closely with progression of intracranial arterial stenosis (P = 0.002). CONCLUSIONS: Arterial vessel wall enhancement in MMV patients was closely related to progression of intracranial arterial stenosis. Strong enhancement of the intracranial vessel wall was associated with intracranial arterial stenosis progression, and lack of enhancement correlated with the stability of intracranial arterial stenosis.

    DOI: 10.1016/j.wneu.2018.05.181

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  144. Predictive factors for the outcomes of initial I-131 low-dose ablation therapy to Japanese patients with differentiated thyroid cancer. Reviewed

    Shinji Ito, Shingo Iwano, Katsuhiko Kato, Shinji Naganawa

    Annals of nuclear medicine   Vol. 32 ( 6 ) page: 418 - 424   2018.7

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    OBJECTIVE: To identify prognostic factors associated with a low-iodine diet (LID) and the amount of remnant thyroid tissue in Japanese patients with differentiated thyroid cancer (DTC) who received initial I-131 remnant ablation (RAI) using a fixed low dose of I-131 (1110 MBq). PATIENTS AND METHODS: In this prospective study, we enrolled 45 patients. Patients were classified into a self-managed LID group and a strict LID group. We measured the urinary iodine concentration on the day of RAI after patients consumed LID for 2 weeks. Thyroid-stimulating hormone-induced thyroglobulin (Tg) levels and I-131 uptake by the remnant thyroid tissue were also evaluated. A response-evaluation whole-body scan (WBS) was performed 6-8 months after RAI to determine the outcome of the therapy. RESULTS: Post-LID urinary iodine levels of the strict LID group tended to be lower than those of the self-managed LID group. Twenty-five cases (56%) showed absence of uptake, whereas 20 cases (44%) showed residual uptake on the response-evaluation WBS. There were no significant differences between "absence" and "residual" groups in urinary iodine concentrations and Tg levels (p = 0.253 and p = 0.234, respectively). However, significant differences were observed in I-131 uptake by the thyroid bed (p = 0.035). CONCLUSIONS: For patients following the current Japanese method of a 2-week LID, the urinary iodine concentration was not a predictive factor for the successful outcome of RAI. In contrast, low I-131 uptake by the thyroid bed, revealed by the scintigram after RAI, may serve as a favorable predictive factor.

    DOI: 10.1007/s12149-018-1261-0

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  145. 【膵癌update】 診断 MRI/MRCP

    小川 浩、竹原康雄、長縄慎二

    臨床消化器内科   Vol. 33 ( 7 ) page: 789-793   2018.7

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  146. Study Protocol: Prospective Study of Concurrent Chemoradiotherapy with S-1 and Hypofractionated Radiotherapy for Outpatients with Early Glottic Squamous Cell Carcinomas Reviewed International journal

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Seiji Kubota, Mariko Kawamura, Rie Nakahara, Yumi Oie, Yuka Kozai, Yuuki Takase, Hidenori Tsuzuki, Naoki Nishio, Mariko Hiramatsu, Yasushi Fujimoto, Takefumi Mizutani, Akihiro Hirakawa, Shinji Naganawa

    Asian Pacific journal of cancer prevention : APJCP   Vol. 19 ( 5 ) page: 1195 - 1199   2018.5

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    Background: The recommended treatment strategies for early glottic carcinoma with intent of larynx preservation are
    primarily radiotherapy. However, the outcomes of radiotherapy for bulky T1 or T2 glottic carcinoma are unsatisfactory.
    We designed a protocol consisting of concurrent chemoradiotherapy using S-1 as the radiosensitizer. We have performed
    this protocol in patients with favorable T2 lesions and demonstrated its efficacy and safety. In contrast, we have
    treated non-bulky T1 glottic carcinomas with 2.25 Gy per fraction, for a total of 25-28 fractions, starting in 2011 to
    improve efficacy and shorten the treatment period. Since this treatment strategy was implemented for T1 disease, no
    local failure has occurred to date, and it appears to be almost as safe as radiotherapy using 2.0 Gy per fraction. With
    the aim of improving the local control rate and shortening the treatment period primarily for favorable T2 disease, we
    changed the dose of radiation in our protocol from 2.0 Gy to 2.25 Gy per fraction, for a total of 25 fractions (from 30
    fractions). The present study aims to evaluate the efficacy and safety of this new protocol. Methods: This study will
    be conducted as a clinical, prospective, single-armed, non-randomized trial. Patients are to receive S-1 (55.3 mg /m2
    /day, once daily) and radiotherapy (2.25 Gy per fraction, for a total of 25 fractions). S-1 and radiotherapy are started
    on the same day that radiotherapy is performed, 3-6 hours after oral administration of S-1. The primary study aim is
    the 3-year local control rate. The secondary study aims are overall survival, voice-preservation survival, disease-free
    survival, complete response rate, completion rate, and toxicity. Result and conclusion: This is the first single-center,
    non-randomized, prospective study of concurrent chemoradiotherapy with S-1 and hypofractionated radiotherapy to
    be conducted. The trial will evaluate the efficacy and safety of our protocol.

    DOI: 10.22034/APJCP.2018.19.5.1195

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  147. Inter-individual Comparison of Gadobutrol and Gadoteridol Tissue Time-intensity Profiles for Dynamic Susceptibility Contrast Perfusion MR Imaging.

    Yamada M, Taoka T, Kawaguchi A, Yasuda K, Niinomi Y, Ohashi Y, Okuda T, Naganawa S

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2018.5

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    DOI: 10.2463/mrms.mp.2017-0172

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  148. Evaluation of the tumoricidal and pain relief effects of Sr-89 on bone metastases of cancer by F-18-fluoride PET/CT, F-18-FDG PET/CT, bone scintigraphy/SPECT, and follow-up

    Kato Katsuhiko, Odagawa Tetsuro, Fujita Naotoshi, Tsutsumi Yoshinori, Matsuzawa Shinichiro, Mukumoto Ryuto, Hasegawa Chinatsu, Abe Shinji, Naganawa Shinji

    JOURNAL OF NUCLEAR MEDICINE   Vol. 59   page: .   2018.5

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  149. Phase I study of chemoradiotherapy using gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic cancer. Reviewed International journal

    Suguru Yamada, Tsutomu Fujii, Yukihiro Yokoyama, Hiroki Kawashima, Osamu Maeda, Kojiro Suzuki, Tohru Okada, Eizaburo Ono, Junpei Yamaguchi, Nao Takano, Hideki Takami, Masamichi Hayashi, Yukiko Niwa, Yoshiki Hirooka, Yoshiyuki Ito, Shinji Naganawa, Yuichi Ando, Masato Nagino, Hidemi Goto, Yasuhiro Kodera

    Cancer chemotherapy and pharmacology   Vol. 81 ( 5 ) page: 815 - 821   2018.5

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    PURPOSE: For unresectable locally advanced (UR-LA) pancreatic cancer, chemoradiotherapy has been recommended by the NCCN guidelines. We designed a chemoradiotherapy protocol using nab-paclitaxel combined with gemcitabine (GnP) for patients with UR-LA pancreatic cancer. The purpose of this phase I study was to determine a recommended dose (RD) for this novel regimen. METHODS: Patients with UR-LA pancreatic cancer were eligible. The frequency of dose-limiting toxicities (DLTs) was evaluated, and the RD was determined. Patients were classified according to the designated dose levels of chemoradiotherapy using the GnP regimen. After additional 6 cycles of the GnP regimen were administered, surgery was considered if the patients had stable disease and tumor marker levels had normalized. RESULTS: DLT (grade 4 thrombocytopenia) was observed only in 1 of 12 patients, and the RD was set at level 3. Grade 3-4 leukopenia was observed in 9 (75.0%) patients, and neutropenia in 7 (58.3%). The response rate was 41.7%, and the disease control rate was 100%. Conversion surgery was performed in 6 (50%) patients, and curative resection (R0) was performed in all 6 patients (100%). Stratification according to the Evans classification system demonstrated one patient with grade 1b, one with grade 2, two with grade 3, and two with grade 4 disease. CONCLUSION: The RD for weekly administration was 800 mg/m2 for gemcitabine and 100 mg/m2 for nab-paclitaxel with a 50.4 Gy radiation. The GnP regimen at this dosage was promising with 6 of 12 patients proceeding to conversion surgery, and should be evaluated further in a phase II trial.

    DOI: 10.1007/s00280-018-3554-3

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  150. 【膵癌update】診断 MRI/MRCP

    小川 浩, 竹原 康雄, 長縄 慎二

    臨床消化器内科   Vol. 33 ( 7 ) page: 789 - 793   2018.5

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  151. Diagnostic performance of <sup>18</sup>F-FDG PET/CT and whole-body diffusion-weighted imaging with background body suppression (DWIBS) in detection of lymph node and bone metastases from pediatric neuroblastoma.

    Ishiguchi H, Ito S, Kato K, Sakurai Y, Kawai H, Fujita N, Abe S, Narita A, Nishio N, Muramatsu H, Takahashi Y, Naganawa S

    Annals of nuclear medicine     2018.4

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    DOI: 10.1007/s12149-018-1254-z

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  152. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan.

    Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Wakabayashi T, Kuzuya M, Ozaki N, Hoshiyama M, Isoda H, Naganawa S, Sobue G

    NeuroImage   Vol. 169   page: 134 - 144   2018.4

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    DOI: 10.1016/j.neuroimage.2017.12.014

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  153. Efficacy of percutaneous transhepatic portal vein embolization using gelatin sponge particles and metal coils. Reviewed International journal

    Tomohiro Komada, Kojiro Suzuki, Takashi Mizuno, Tomoki Ebata, Masaya Matsushima, Shinji Naganawa, Masato Nagino

    Acta radiologica open   Vol. 7 ( 4 ) page: 2058460118769687 - 2058460118769687   2018.4

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    Background: Percutaneous transhepatic portal vein embolization (PTPE) can increase the future liver remnant (FLR) volume before extended liver resection; however, there is no current consensus regarding the best embolic material for PTPE. Purpose: To evaluate the efficacy of PTPE using gelatin sponge particles and coils. Material and Methods: The medical records of 136 patients who underwent PTPE using gelatin sponge particles and metal coils were retrospectively reviewed. We evaluated the procedural details, liver volume on CT, and clinical status before and after PTPE. Results: The mean FLR volume increased significantly from 390 ± 147 cm3 to 508 ± 141 cm3 (P < 0.001). A mean of 22.1 ± 9.4 days after PTPE, the mean increase in the ratio of FLR volume to total liver volume was 9.4 ± 6.5%. Complications related to PTPE occurred in five patients, including arterial damage (n = 4) and biloma (n = 1). The white blood cell count and C-reactive protein level increased significantly and then returned to baseline within seven days. Aspartate aminotransferase and alanine aminotransferase showed no significant changes. Fever (defined by the Common Terminology Criteria for Adverse Events v4.0) was reported in 74 patients (54%), but it was generally mild (Grade 1/2; n = 72). None of the patients experienced severe complications that required cancellation of surgery. Conclusion: PTPE with gelatin sponge particles and coils may impose low physical stress on patients and is a safe method of inducing a significant increase of FLR.

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  154. Tau Kinetics in Neurons and the Human Central Nervous System

    Sato Chihiro, Barthelemy Nicolas R., Mawuenyega Kwasi G., Patterson Bruce W., Gordon Brian A., Jockel-Balsarotti Jennifer, Sullivan Melissa, Crisp Matthew J., Kasten Tom, Kirmess Kristopher M., Kanaan Nicholas M., Yarasheski Kevin E., Baker-Nigh Alaina, Benzinger Tammie L. S., Miller Timothy M., Karch Celeste M., Bateman Randall J.

    NEURON   Vol. 97 ( 6 ) page: 1284 - +   2018.3

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    DOI: 10.1016/j.neuron.2018.02.015

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  155. Computer-aided Volumetry of Part-Solid Lung Cancers by Using CT: Solid Component Size Predicts Prognosis.

    Kamiya S, Iwano S, Umakoshi H, Ito R, Shimamoto H, Nakamura S, Naganawa S

    Radiology     page: 172319   2018.3

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    DOI: 10.1148/radiol.2018172319

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  156. Improved 3D-real Inversion Recovery: A Robust Imaging Technique for Endolymphatic Hydrops after Intravenous Administration of Gadolinium.

    Naganawa S, Kawai H, Taoka T, Sone M

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2018.3

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    DOI: 10.2463/mrms.bc.2017-0158

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  157. Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease.

    Kawabata K, Watanabe H, Hara K, Bagarinao E, Yoneyama N, Ogura A, Imai K, Masuda M, Yokoi T, Ohdake R, Tanaka Y, Tsuboi T, Nakamura T, Hirayama M, Ito M, Atsuta N, Maesawa S, Naganawa S, Katsuno M, Sobue G

    Journal of neurology   Vol. 265 ( 3 ) page: 688-700   2018.3

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    DOI: 10.1007/s00415-018-8755-5

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  158. Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease

    Kawabata Kazuya, Watanabe Hirohisa, Hara Kazuhiro, Bagarinao Epifanio, Yoneyama Noritaka, Ogura Aya, Imai Kazunori, Masuda Michihito, Yokoi Takamasa, Ohdake Reiko, Tanaka Yasuhiro, Tsuboi Takashi, Nakamura Tomohiko, Hirayama Masaaki, Ito Mizuki, Atsuta Naoki, Maesawa Satoshi, Naganawa Shinji, Katsuno Masahisa, Sobue Gen

    JOURNAL OF NEUROLOGY   Vol. 265 ( 3 ) page: 688-700   2018.3

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    DOI: 10.1007/s00415-018-8755-5

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  159. 特集 脳脊髄液動態のすべて 脳脊髄液による老廃物のクリアランス―glymphaticシステム―

    田岡俊昭、長縄慎二

    画像診断   Vol. 38 ( 3 ) page: 268-276   2018.3

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  160. MR画像による脳内の物質輸送機構の解明

    長縄慎二、田岡俊昭、川井 恒

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成   平成29年度活動報告書     page: 25-26   2018.3

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  161. 脳とこころの研究センター長 挨拶

    長縄慎二

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成   平成29年度活動報告書     page: 1   2018.3

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  162. 後下小脳動脈抹消部動脈瘤の診断におけるthin slab MIP法の有用性

    長縄慎二

    日本脳神経CI学会機関誌   Vol. 39 ( 3-4 ) page: 121-130   2018.3

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  163. Patients with anti-thyroid antibodies are prone to develop destructive thyroiditis by nivolumab: a prospective study Reviewed

    Tomoko Kobayashi, Shintaro Iwama, Yoshinori Yasuda, Norio Okada, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Yoshiaki Morishita, Motomitsu Goto, Hidetaka Suga, Ryoichi Banno, Kenji Yokota, Tetsunari Hase, Masahiro Morise, Naozumi Hashimoto, Masahiko Ando, Hitoshi Kiyoi, Momokazu Gotoh, Yuichi Ando, Masashi Akiyama, Yoshinori Hasegawa, Hiroshi Arima

    Journal of the Endocrine Society     2018.2

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    DOI: 10.1210/js.2017-00432

  164. Detecting sub-second changes in brain activation patterns during interictal epileptic spike using simultaneous EEG-fMRI. Reviewed International journal

    Epifanio Bagarinao, Satoshi Maesawa, Yuji Ito, Naotaka Usui, Jun Natsume, Hirohisa Watanabe, Minoru Hoshiyama, Toshihiko Wakabayashi, Gen Sobue, Shinji Naganawa, Haruo Isoda

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology   Vol. 129 ( 2 ) page: 377 - 389   2018.2

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    OBJECTIVE: Epileptic spikes are associated with rapidly changing brain activation involving the epileptic foci and other brain regions in the "epileptic network". We aim to resolve these activation changes using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings. METHODS: Simultaneous EEG-fMRI recordings from 9 patients with epilepsy were used in the analysis. Our method employed the whole scalp EEG data to generate regressors for the analysis of fMRI data using the general linear model. RESULTS: We were able to resolve, with milliseconds temporal resolution, changes in activation patterns involving suspected epileptic foci and other brain regions in the epileptic network during spike and slow wave. Using summary maps (called SSWAS maps) which show the activation frequency of voxels, we found that suspected epileptic foci tend to be significantly active during this interval. SSWAS maps also enabled the detection of the epileptic foci in 4 of 5 patients where the conventional event-timing-based analysis failed to identify. CONCLUSION: These findings demonstrated the efficacy of the method and the potential application of SSWAS maps to identify epileptic foci. SIGNIFICANCE: The method could help resolve activation changes during epileptic spike and could provide insights into the underlying pathophysiology of these changes.

    DOI: 10.1016/j.clinph.2017.11.018

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  165. Imaging of the endolymphatic space in patients with Ménière's disease. Reviewed International journal

    Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Hironao Otake, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

    Auris, nasus, larynx   Vol. 45 ( 1 ) page: 33 - 38   2018.2

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    OBJECTIVE: To examine endolymphatic hydrops (EH) using magnetic resonance imaging (MRI) in patients with definite Ménière's disease (MD) and those with nonotological diseases. METHODS: We studied 32 patients with unilateral MD, 10 patients with bilateral MD and 21 patients with control ears who had other benign diseases not associated with hearing or vestibular dysfunction. The mean age of the subjects was 54.0 years (range 27-74) in the MD group and 56.1 years (range 24-79) in the control group. Using MRI, the degree of EH was classified as none, mild and significant in the cochlea and vestibule separately. The ratio of the area of endolymphatic space to the vestibular fluid space was calculated for the vestibule. The duration of MD was defined as the months between the first attack of MD and the MRI study. RESULTS: EH was present in the cochlea of 45/52 affected ears of patients with MD (87%) and in 16/42 control ears (38%). Significant cochlear hydrops was present in 37/52 affected ears (71%) and in 4/42 control ears (10%). EH in the vestibule was present in 49/52 affected ears (94%) and in 3/42 control ears (7%). Significant vestibular hydrops was present in 40/52 affected ears (77%) and in none of the 42 control ears. There was no relationship between the degree of EH and its duration. Using a cut off value for the relative size of EH in the vestibule of 41.9%, the test had a sensitivity of 88.5% and a specificity of 100% to diagnose definite MD. CONCLUSION: Cochlear EH was occasionally observed in control ears on MRI, as in normal temporal bone specimens. The presence or absence and degree of vestibular EH were significantly different between ears with MD and control ears. EH in the vestibule might be a specific predictor of definite MD.

    DOI: 10.1016/j.anl.2017.02.002

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  166. 早期声門癌に対するS-1併用化学放射線療法の長期成績

    高瀬 裕樹, 伊藤 善之, 木村 香菜, 岡田 徹, 久保田 誠司, 川村 麻里子, 中原 理絵, 大家 祐実, 香西 由加, 長縄 慎二, 藤本 保志, 曾根 三千彦

    Japanese Journal of Radiology   Vol. 36 ( Suppl. ) page: 22 - 22   2018.2

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  167. Differences in Signal Intensity and Enhancement on MR Images of the Perivascular Spaces in the Basal Ganglia versus Those in White Matter. Reviewed

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka

    Magn Reson Med Sci.     2018.1

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    DOI: 10.2463/mrms.mp.2017-0137.

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  168. Gadolinium-based Contrast Media, Cerebrospinal Fluid and the Glymphatic System: Possible Mechanisms for the Deposition of Gadolinium in the Brain. Reviewed

    Toshiaki Taoka, Shinji Naganawa

    Magn Reson Med Sci.     2018.1

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    DOI: 10.2463/mrms.rev.2017-0116.

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  169. Differences in Signal Intensity and Enhancement on MR Images of the Perivascular Spaces in the Basal Ganglia versus Those in White Matter

    Naganawa Shinji, Nakane Toshiki, Kawai Hisashi, Taoka Toshiaki

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 17 ( 4 ) page: 301-307   2018

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    DOI: 10.2463/mrms.mp.2017-0137

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  170. Clinical MR imaging of endolymphatic hydrops: Updates on scanning methods, image processing and interpretation. Reviewed

    Shinji Naganwa

    Solutions in Contrast Imaging.   Vol. 9 ( 5 ) page: 1-5   2018

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  171. Dosimetric feasibility of using tungsten-based functional paper for flexible chest wall protectors in intraoperative electron radiotherapy for breast cancer. Reviewed International journal

    Takeshi Kamomae, Hajime Monzen, Mariko Kawamura, Kuniyasu Okudaira, Takayoshi Nakaya, Takashi Mukoyama, Yoshikazu Miyake, Yoshitomo Ishihara, Yoshiyuki Itoh, Shinji Naganawa

    Physics in medicine and biology   Vol. 63 ( 1 ) page: 015006 - 015006   2017.12

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    Intraoperative electron radiotherapy (IOERT), which is an accelerated partial breast irradiation method, has been used for early-stage breast cancer treatment. In IOERT, a protective disk is inserted behind the target volume to minimize the dose received by normal tissues. However, to use such a disk, the surgical incision must be larger than the field size because the disk is manufactured from stiff and unyielding materials. In this study, the applicability of newly developed tungsten-based functional paper (TFP) was assessed as an alternative to the existing protective disk. The radiation-shielding performance of the TFP was verified through experimental measurements and Monte Carlo simulations. Percentage depth dose curves and lateral dose profiles with and without TFPs were measured and simulated on a dedicated IOERT accelerator. The number of piled-up TFPs was changed from 1 to 40. In the experimental measurements, the relative doses at the exit plane of the TFPs for 9 MeV were 42.7%, 9.2%, 0.2%, and 0.1% with 10, 20, 30, and 40 TFPs, respectively, whereas those for 12 MeV were 63.6%, 27.1%, 8.6%, and 0.2% with 10, 20, 30, and 40 TFPs, respectively. Slight dose enhancements caused by backscatter radiation from the TFPs were observed at the entrance plane of the TFPs at both beam energies. The results of the Monte Carlo simulation indicated the same tendency as the experimental measurements. Based on the experimental and simulated results, the radiation-shielding performances of 30 TFPs for 9 MeV and 40 TFPs for 12 MeV were confirmed to be acceptable and close to those of the existing protective disk. The findings of this study suggest the feasibility of using TFPs as flexible chest wall protectors in IOERT for breast cancer treatment.

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  172. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan. Reviewed

    Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshihiko Wakabayashi, Masafumi Kuzuya, NorioOzaki, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Gen Sobue

    Neuroimage   ( 169 ) page: 134-144   2017.12

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  173. Three-dimensional printer-generated patient-specific phantom for artificial in vivo dosimetry in radiotherapy quality assurance. Reviewed International journal

    Takeshi Kamomae, Hidetoshi Shimizu, Takayoshi Nakaya, Kuniyasu Okudaira, Takahiro Aoyama, Hiroshi Oguchi, Masataka Komori, Mariko Kawamura, Kazuhiro Ohtakara, Hajime Monzen, Yoshiyuki Itoh, Shinji Naganawa

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)   Vol. 44   page: 205 - 211   2017.12

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    Pretreatment intensity-modulated radiotherapy quality assurance is performed using simple rectangular or cylindrical phantoms; thus, the dosimetric errors caused by complex patient-specific anatomy are absent in the evaluation objects. In this study, we construct a system for generating patient-specific three-dimensional (3D)-printed phantoms for radiotherapy dosimetry. An anthropomorphic head phantom containing the bone and hollow of the paranasal sinus is scanned by computed tomography (CT). Based on surface rendering data, a patient-specific phantom is formed using a fused-deposition-modeling-based 3D printer, with a polylactic acid filament as the printing material. Radiophotoluminescence glass dosimeters can be inserted in the 3D-printed phantom. The phantom shape, CT value, and absorbed doses are compared between the actual and 3D-printed phantoms. The shape difference between the actual and printed phantoms is less than 1 mm except in the bottom surface region. The average CT value of the infill region in the 3D-printed phantom is -6 ± 18 Hounsfield units (HU) and that of the vertical shell region is 126 ± 18 HU. When the same plans were irradiated, the dose differences were generally less than 2%. These results demonstrate the feasibility of the 3D-printed phantom for artificial in vivo dosimetry in radiotherapy quality assurance.

    DOI: 10.1016/j.ejmp.2017.10.005

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  174. Longitudinal up-regulation of endolymphatic hydrops in patients with Meniere's disease during medical treatment. Reviewed International journal

    Munehisa Fukushima, Tadashi Kitahara, Ryohei Oya, Shiro Akahani, Hidenori Inohara, Shinji Naganawa, Noriaki Takeda

    Laryngoscope investigative otolaryngology   Vol. 2 ( 6 ) page: 344 - 350   2017.12

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    Objective/Hypothesis: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Study Design: Prospective, single-arm repeated measures. Methods: Eleven MD patients were enrolled. All subjects prospectively underwent gadolinium-enhanced inner ear magnetic resonance (MR) imaging and neuro-otological testing before and after medical treatment. The volume of EH was quantitatively evaluated by processing MR images. All MD patients were administered continuous medication and followed up for more than 12 months. Results: The frequency of vertigo episodes decreased in all patients and vestibular function decreased to 13-91% of the pre-treatment level. The volume ratio of post-treatment EH-to-pre-treatment EH ranged from 1.01-3.22. The total volume of pre-treatment EH was significantly correlated with cochlear symptom disease duration and the affected ear's hearing level. Conclusion: EH in MD patients developed longitudinally with deterioration of inner ear function during medical treatment. The natural course of MD may progress with development of EH at least for a certain period. Level of Evidence: 2b.

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  175. The relationship between endolymphatic hydrops in the vestibule and low-frequency air-bone gaps.

    Sugimoto S, Yoshida T, Teranishi M, Okazaki Y, Naganawa S, Sone M

    The Laryngoscope     2017.11

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    DOI: 10.1002/lary.26898

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  176. The Relationship Between Endolymphatic Hydrops in the Vestibule and Low-Frequency Air-Bone Gaps.

    Satofumi Sugimoto, Tadao Yoshida, Masaaki Teranishi, Yuriko Okazaki, Shinji Naganawa, Michihiko Sone

    Laryngoscope.     2017.11

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    DOI: 10.1002/lary.26898.

  177. Letter to editor [Saccular measurements in routine MRI can predict hydrops in Meniele disease] by Simon F et al.

    Pablo Dominguez, Shinji Naganawa

    Eur Arch Otorhinolaryngol.     2017.11

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    DOI: 10.1007/s00405-017-4794-2

  178. Structural MRI correlates of amyotrophic lateral sclerosis progression. Reviewed International journal

    Joe Senda, Naoki Atsuta, Hirohisa Watanabe, Epifanio Bagarinao, Kazunori Imai, Daichi Yokoi, Yuichi Riku, Michihito Masuda, Ryoichi Nakamura, Hazuki Watanabe, Mizuki Ito, Masahisa Katsuno, Shinji Naganawa, Gen Sobue

    Journal of neurology, neurosurgery, and psychiatry   Vol. 88 ( 11 ) page: 901 - 907   2017.11

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    PURPOSE: Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical course and progression of ALS varies widely. Brain degeneration detected using structural MRI could reflect disease progression. SUBJECTS AND METHODS: On study registration, 3-Tesla volumetric MRI and diffusion tensor imaging scans were obtained at baseline in 38 healthy controls and 67 patients with sporadic ALS. Patients had Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) scores of ≥36 and did not have the chromosome 9, open reading frame 72 repeat expansion. Six months later, changes in ALSFRS-R (ΔALSFRS-R) scores were calculated and patients were grouped into three categories, namely, patients with slow progression with ΔALSFRS-R scores ≤3 (n=19), intermediate progression with ΔALSFRS-R scores =4, 5 and 6 (n=36) and rapid progression with ΔALSFRS-R scores ≥7 (n=12). We analysed voxel-based morphometry and tract-based spatial statistics among these subgroups and controls. RESULTS: In comparison with controls, patients with ALS showed grey matter atrophy and decreased fractional anisotropy beyond the motor cortex and CST, especially in the frontotemporal lobes and basal ganglia. Moreover, the degree of change was highly proportional to ΔALSFRS-R at the 6-month assessment. CONCLUSION: A more rapid disease progression and poorer functional decline were associated with greater involvement of the extra-motor cortex and basal ganglia, suggesting that the spatial extent of brain involvement can be an indicator of the progression in ALS.

    DOI: 10.1136/jnnp-2016-314337

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  179. Clinical outcomes of 125I brachytherapy with and without external-beam radiation therapy for localized prostate cancer: results from 300 patients at a single institution in Japan. Reviewed International journal

    Sayo Maki, Yoshiyuki Itoh, Seiji Kubota, Tohru Okada, Rie Nakahara, Junji Ito, Mariko Kawamura, Shinji Naganawa, Yasushi Yoshino, Takashi Fujita, Masashi Kato, Momokazu Gotoh, Mitsuru Ikeda

    Journal of radiation research   Vol. 58 ( 6 ) page: 870 - 880   2017.11

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    The aim of this study was to determine the outcomes and adverse events for 300 men with prostate cancer treated with 125iodine (125I) brachytherapy with and without external-beam radiation therapy (EBRT) at a single institution in Japan. Between February 2005 and November 2011, 300 consecutive patients with clinically localized prostate cancer were treated with 125I brachytherapy at the Nagoya University Hospital. A total of 271 men were treated with implants with doses of 145 Gy, and 29 men were treated with implants with doses of 110 Gy combined with EBRT (40-50 Gy/20-25 fractions). The median patient age was 69 years (range, 53-83 years). The median follow-up period was 53 months (range, 5-99 months). According to the National Comprehensive Cancer Network risk classification, 132 men (44%) had low-risk, 147 men (29%) had intermediate-risk and 21 men (7%) had high-risk disease. The 5-year overall survival rate, biochemical relapse-free survival rate, and disease-specific survival rates were 93.5%, 97.3% and 98.5%, respectively. Two men (0.6%) died of prostate cancer and 10 men (3.3%) died of other causes. Seventeen men (5.6%) experienced Grade 2 rectal bleeding in all: 12 (41.4%) of 29 in brachytherapy with EBRT, and 5 (1.8%) of 271 in brachytherapy alone. The rates of Grade 2 and 3 genitourinary toxicity were 1.0% and 1.7%, respectively. Excellent local control was achieved at our hospital for localized prostate cancer with 125I brachytherapy with and without EBRT. Gastrointestinal and genitourinary toxicities were acceptable.

    DOI: 10.1093/jrr/rrx051

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  180. 【局所進行膵癌の治療限界に挑む】局所進行膵癌の術前治療後の画像診断

    小川 浩, 鈴木 耕次郎, 竹原 康雄, 長縄 慎二

    胆と膵   Vol. 38 ( 11 ) page: 1255 - 1260   2017.11

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    膵癌は、血管浸潤の範囲と遠隔転移・腹膜播種の有無により、切除可能、切除境界、切除不能に分類される。このうち、局所進行膵癌である切除境界および切除不能膵癌に関しては、化学療法あるいは化学放射線療法により癌細胞が減少し、外科的切除が可能となる症例が存在する。膵癌の治療効果判定は、CTやMRI、PETといった画像や、CA19-9などの腫瘍マーカーの推移でみるのが一般的である。ここでは、とくに局所進行膵癌の術前治療後の画像診断について述べ、さらに化学放射線療法後に生じる多彩な画像上の変化についても言及する。(著者抄録)

  181. Improved HYDROPS: Imaging of Endolymphatic Hydrops after Intravenous Administration of Gadolinium. Reviewed

    Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Michihiko Sone

    Magn Reson Med Sci.   ( 16 ) page: 357-361   2017.10

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  182. Three-dimensional printer-generated patient-specific phantom for artificial in vivo dosimetry in radiotherapy quality assurance. Reviewed

    Takeshi Kamomae, Hidetoshi Shimizu, Takayoshi Nakaya, Kuniyasu Okudaira, Takahiro Aoyama, Hiroshi Oguchi, Masataka Komori, Mariko Kawamura, Kazuhiro Ohtakara, Hajime Monzen, Yoshiyuki Itoh, Shinji Naganawa

    Phys Med.     2017.10

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    DOI: 10.1016/j.ejmp.2017.10.005.

  183. Longitudinal Up-Regulation of Endolymphatic Hydrops in Patients with Meniere's Disease During Medical Treatment. Reviewed

    Munehisa Fukushima, Tadashi Kitahara, Ryohei Oya, Shiro Akahani, Hidenori Inohara, Shinji Naganawa, Noriaki Takeda

    Laryngoscope Investigative Otolaryngology.   Vol. - ( - )   2017.10

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  184. A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological invasiveness of non-small cell lung cancer. Reviewed International journal

    Rintaro Ito, Shingo Iwano, Hironori Shimamoto, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Ito, Katsuhiko Kato, Shinji Naganawa

    European journal of radiology   Vol. 95   page: 186 - 191   2017.10

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    PURPOSE: To compare dual-phase dual-energy CT (DE-CT) with FDG-PET/CT for predicting histopathological locoregional invasiveness of non-small cell lung cancers (NSCLCs). MATERIALS AND METHODS: We selected 63 consecutive patients with NSCLC lesions (37 males, 26 females; age range, 44-85 years; mean age, 69 years) who were evaluated preoperatively by both DE-CT and PET/CT at our institution. Postoperative microscopic invasiveness (lymphatic permeation, vascular invasion, and/or pleural involvement) was reviewed, and we defined locoregionally invasive tumors as those that had at least one positive finding of microscopic invasiveness. DE-CT scanning in the arterial and delayed phases was performed after injection of iodinated contrast media using 140-kVp and 80-kVp tube voltages. Three-dimensional iodine-related attenuation of primary tumors in the arterial and delayed phases was quantified automatically using "syngo Dual Energy Lung Nodules" application software, and the ratio of arterial phase to delayed phase enhancement (A/D ratio) was calculated. The A/D ratio and SUVmax on PET/CT were evaluated with respect to postoperative invasiveness by univariate logistic regression analysis. RESULTS: The A/D ratio was significantly correlated with lymphatic permeation, vascular invasion, and pleural involvement (p=0.011, p=0.021, and p=0.010, respectively). In contrast, the SUVmax was significantly correlated with pleural involvement (p=0.020) but not with lymphatic permeation or vascular invasion (p=0.088 and p=0.100, respectively). In the subgroup of patients with lesion diameters ≤2cm, the A/D ratio was significantly correlated with locoregional invasiveness (p=0.040), while the SUVmax was not (p=0.121). CONCLUSION: For the prediction of microscopic invasiveness of NSCLCs, the diagnostic performance of dual-phase DE-CT may be comparable to that of FDG-PET/CT.

    DOI: 10.1016/j.ejrad.2017.08.010

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  185. Comparison of I-123-IMP SPECT, F-18-FDG PET/CT, and F-18-FDOPA PET/CT in Detection of Choroidal Malignant Melanoma

    Kato K., Odagawa T., Tsutsumi T., Honda M., Kunimoto K., Mukumoto R., Matsuzawa S., Abe S., Naganawa S.

    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING   Vol. 44   page: S745-S745   2017.10

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  186. ちょっと気になる胆・膵画像 ティーチングファイルから(第36回) 主膵管内腫瘍栓を呈した腺房細胞癌の1例

    小川 浩, 竹原 康雄, 館 靖, 長縄 慎二, 鈴木 耕次郎, 廣岡 芳樹, 山田 豪, 藤井 努, 下山 芳江

    胆と膵   Vol. 38 ( 10 ) page: 1131 - 1134   2017.10

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  187. Appearance of the Organum Vasculosum of the Lamina Terminalis on Contrast-enhanced MR Imaging.

    Naganawa S, Taoka T, Kawai H, Yamazaki M, Suzuki K

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     2017.9

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    DOI: 10.2463/mrms.mp.2017-0088

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  188. Significance of Endolymphatic Hydrops in Ears With Unilateral Sensorineural Hearing Loss. Reviewed

    Yuriko Okazaki, Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Ken Kato, Shinji Naganawa, Michihiko Sone

    Otol Neurotol.   Vol. 38 ( 8 ) page: 1076-1080   2017.9

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  189. Clinical usefulness of MLCs in robotic radiosurgery systems for prostate SBRT. Reviewed

    Masashi Tomida, Takeshi Kamomae, Junji Suzuki, Yoichi Ohashi, Yoshiyuki Itoh, Hiroshi Oguchi, Takahito Okuda

    J Appl Clin Med Phys.   Vol. 18 ( 5 ) page: 124-133   2017.9

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  190. Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall: A pilot study. Reviewed

    Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    PLoS One.   Vol. 12 ( 9 ) page: e0185532.   2017.9

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  191. Significance of Endolymphatic Hydrops in Ears With Unilateral Sensorineural Hearing Loss. International journal

    Yuriko Okazaki, Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Ken Kato, Shinji Naganawa, Michihiko Sone

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology   Vol. 38 ( 8 ) page: 1076 - 1080   2017.9

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    OBJECTIVE: The purpose of this study was to investigate the existence of endolymphatic hydrops (EH) in affected and unaffected ears in patients with unilateral sensorineural hearing loss (SNHL) using contrast-enhanced magnetic resonance imaging (MRI), and to evaluate the significance of EH in various otological diseases. STUDY DESIGN: Retrospective study. SETTING: University hospital. METHODS: One hundred eighty-two ears from 91 patients with unilateral SNHL were studied. The endolymphatic space was evaluated using 3-Tesla MRI with gadodiamide hydrate. Imaging data about the degree of EH in the cochlea and vestibule were analyzed and compared between ears with various otological diseases. RESULTS: All affected ears with delayed endolymphatic hydrops had EH. In affected ears with definite Menière's disease, cochlear EH was observed in all ears and vestibular EH in 93% of ears, and these rates were significantly higher in the affected than in the unaffected ears. EH was also observed in the cochlea and vestibule in 66% and 41%, respectively, of the affected ears with idiopathic sudden SNHL; however, these percentages did not differ significantly from those in the unaffected ears (52% and 38%, respectively). CONCLUSION: MRI showed that a high percentage of ears affected by Menière's disease or delayed endolymphatic hydrops had EH. Further studies should evaluate the implications of EH in ears, especially in those with sudden SNHL, in terms of secondary or pre-existing EH.

    DOI: 10.1097/MAO.0000000000001499

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  192. Letter to Editors: Detection of endolymphatic hydrops using traditional MR imaging sequences

    Shinji Naganawa, Michihiko Sone

    American Journal of Otolaryngology - Head and Neck Medicine and Surgery   Vol. 38 ( 5 ) page: 637 - 638   2017.9

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    DOI: 10.1016/j.amjoto.2017.06.014

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  193. FDG-PET/CT predicts survival and lung metastasis of hypopharyngeal cancer in a multi-institutional retrospective study. Reviewed

    Hidenori Suzuki, Katsuhiko Kato, Masami Nishio, Tsuneo Tamaki, Yasushi Fujimoto, Mariko Hiramatsu, Nobuhiro Hanai, Takeshi Kodaira, Yoshiyuki Itoh, Shinji Naganawa, Michihiko Sone, Yasuhisa Hasegawa

    Ann Nucl Med.   Vol. 31 ( 7 ) page: 514-520   2017.8

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  194. A comparative analysis of dual-phase dual-energy CT and FDG-PET/CT for the prediction of histopathological invasiveness of non-small cell lung cancer. Reviewed

    Rintaro Ito, Shingo Iwano, Hironori Shimamoto, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Ito, Katsuhiko Kato, Shinji Naganawa

    European Journal of Radiology.   ( 95 ) page: 186-191   2017.8

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  195. Optimized treatment strategy of radiotherapy for early glottic squamous cell carcinomas: An initial analysis. Reviewed

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Seiji Kubota, Mariko Kawamura, Rie Nakahara, Yumi Oie, Yuka Kozai, Yuuki Takase, Hidenori Tsuzuki, Naoki Nishio, Mariko Hiramatsu, Yasushi Fujimoto, Takefumi Mizutani, Shinji Naganawa

    Nagoya J Med Sci.   Vol. 79 ( 3 ) page: 331-338   2017.8

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  196. FDG-PET/CT predicts survival and lung metastasis of hypopharyngeal cancer in a multi-institutional retrospective study. Reviewed

    Hidenori Suzuki, Katsuhiko Kato, Masami Nishio, Tsuneo Tamaki, Yasushi Fujimoto, Mariko Hiramatsu, Nobuhiro Hanai, Takeshi Kodaira, Yoshiyuki Itoh, Shinji Naganawa, Michihiko Sone, Yasuhisa Hasegawa

    Annals of nuclear medicine   Vol. 31 ( 7 ) page: 514 - 520   2017.8

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    OBJECTIVES: We investigated a possible correlation between the maximum standardized uptake value (SUVmax), which is assessed by pretreatment 18F-fluorodeoxyglucose positron emission tomography with computed tomography, and the overall survival (OS) in patients with hypopharyngeal squamous cell carcinoma from two institutions on long-term follow-up, and examined whether SUVmax is correlated with several survival outcomes, including lung metastasis-free survival. METHODS: A total of 81 patients were enrolled. The survival rate was calculated by the Kaplan-Meier method. Both univariate and multivariate survival analyses were assessed by a Cox proportional hazards model. RESULTS: SUVmax ≥15.2 in institution A (p = 0.0306) or SUVmax ≥8 in institution B (p = 0.0132) was significantly predictor of a lower OS. We disaggregated the data by high SUVmax (SUVmax ≥15.2 from institution A and SUVmax ≥8 from institution B) and low SUVmax (SUVmax <15.2 from institution A and SUVmax <8 from institution B). Patients with a high SUVmax exhibited a significantly lower OS in both univariate (p = 0.001) and multivariate (p = 0.0046) analyses for adjusted for the clinical stage and treatment group. The patients with a high SUVmax exhibited significantly shorter disease-specific (p = 0.0068), distant metastasis-free (p = 0.0428), and lung metastasis-free (p = 0.0328) survivals. CONCLUSIONS: High SUVmax was significantly correlated with a lower OS, disease-specific survival, distant metastasis-free survival, and lung metastasis-free survival in a multi-institutional retrospective study.

    DOI: 10.1007/s12149-017-1176-1

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  197. Optimized treatment strategy of radiotherapy for early glottic squamous cell carcinomas: An initial analysis. Reviewed

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Seiji Kubota, Mariko Kawamura, Rie Nakahara, Yumi Oie, Yuka Kozai, Yuuki Takase, Hidenori Tsuzuki, Naoki Nishio, Mariko Hiramatsu, Yasushi Fujimoto, Takefumi Mizutani, Shinji Naganawa

    Nagoya journal of medical science   Vol. 79 ( 3 ) page: 331 - 338   2017.8

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    The purpose of this study was to evaluate the clinical outcomes of radiotherapy for patients with T1/T2 glottic carcinoma. Patients with T1/T2 glottic carcinoma histopathologically diagnosed with squamous cell carcinoma and treated at our hospital between 2007 and 2015 were analyzed retrospectively. Our strategy for T1/T2 glottic carcinoma was as follows: radiotherapy alone with 2.25 Gy per fraction to a total of 25-28 fractions for patients with non-bulky T1 glottic carcinoma; concurrent chemoradiotherapy with oral S-1 and radiotherapy with 2 Gy per fraction to a total of 30 fractions for patients with T1 bulky/T2 favorable glottic carcinoma; or chemoradiotherapy with high-dose cisplatin and radiotherapy with 2 Gy per fraction to a total of 35 fractions for T2 unfavorable glottic carcinoma. Forty-eight patients were eligible. The median follow-up period among surviving patients was 38 months (range, 11-107). The disease was T1a in 23%, T1b in 13%, and T2 in 65% of patients. The 3-year local control rate in all patients, T1a, T1b, and T2 was 96.7%, 100%, 100%, and 96.0%, respectively. Of the 46 patients, one with T2 glottic carcinoma developed recurrent disease at the primary site, and one with T2 glottic carcinoma had lymph node recurrences in the neck. Acute Grade 3 dermatitis occurred in 8 (17%) patients and late Grade 2 hypothyroidism occurred in 2 (4%) patients. This retrospective study shows that our optimized treatment strategy of radiotherapy depending on the stage of early glottic carcinoma is not only effective but also well-tolerated.

    DOI: 10.18999/nagjms.79.3.331

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  198. Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue Reviewed

    Gregor Jost, Thomas Frenzel, Jessica Lohrke, Diana Constanze Lenhard, Shinji Naganawa, Hubertus Pietsch

    Eur Radiol.   Vol. 27 ( 7 ) page: 2877-2885   2017.7

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  199. Development of the breast immobilization system in prone setup: The effect of bra in prone position to improve the breast setup error. Reviewed International journal

    Mariko Kawamura, Yoshikazu Maeda, Kazutaka Yamamoto, Shigeyuki Takamatsu, Yoshitaka Sato, Hiroki Minami, Yusuke Saga, Kyo Kume, Yuji Tameshige, Makoto Sasaki, Hiroyasu Tamamura, Kouji Ohta, Yoshiyuki Itoh, Shinji Naganawa

    Journal of applied clinical medical physics   Vol. 18 ( 4 ) page: 155 - 160   2017.7

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    PURPOSE/OBJECTIVE(S): Accurate and reproducible positioning of the breast is difficult due to its deformability and softness; thus, targeting a breast tumor or tumor bed with fractionated radiotherapy using external beam radiation is difficult. The aim of this study was to develop a novel bra to aid in breast immobilization in the prone position. MATERIALS & METHODS: To assess the accuracy of prone position fixation of breast tumors, 33 breast cancer patients with 34 lesions were recruited. The bra used in this verification was customized from a commercially available bra. Duplicate MRI were acquired in the prone position, alternating with and without the bra, and for each series, patients were asked to step off the MRI table and re-set up in the prone position. Patients were also asked to remove and re-fit the bra for the second MRI. Each pair of images were superimposed to match the shape of the skin surface, and the maximum difference in tumor geometric center in three axes was measured. The required set up margin was calculated as: required margin = mean difference in geometric center + 2.5 standard deviation. The volumetric overlap of the tumor, as well as contouring uncertainties, was evaluated using contour analysis software. RESULTS: The median breast size was 498 cc. The required margins for the lateral, vertical, and longitudinal directions were estimated to be 4.1, 4.1, and 5.0 mm, respectively, with the bra, and 5.1, 6.9, and 6.7 mm, respectively, without the bra. These margins covered the dislocation of more than 33 lesions in total. With the bra, 33 lesions had achieved an objective overlap of 95% and 99% with 2 and 4 mm margins, respectively, whereas 4 and 8 mm, respectively, were needed without the bra. CONCLUSION: The use of an immobilizing bra reduced the setup margin for prone position fixation of breast tumors.

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  200. Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue Reviewed International journal

    Gregor Jost, Thomas Frenzel, Jessica Lohrke, Diana Constanze Lenhard, Shinji Naganawa, Hubertus Pietsch

    EUROPEAN RADIOLOGY   Vol. 27 ( 7 ) page: 2877 - 2885   2017.7

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    Signal hyperintensity on unenhanced MRI in certain brain regions has been reported after multiple administrations of some, but not all, gadolinium-based contrast agents (GBCAs). One potential initial pathway of GBCA entry into the brain, infiltration from blood into the cerebrospinal fluid (CSF), was systematically evaluated in this preclinical study.
    GBCA infiltration and distribution in the CSF were investigated in healthy rats using repeated fluid-attenuated MRI up to 4 h after high-dose (1.8 mmol/kg) administration of six marketed and one experimental GBCA. Additionally, gadolinium measurements in CSF, blood and brain tissue samples (after 24 h) were performed using inductively coupled plasma mass spectrometry.
    Enhanced MRI signals in the CSF spaces with similar distribution kinetics were observed for all GBCAs. No substantial differences in the gadolinium concentrations among the marketed GBCAs were found in the CSF, blood or brain tissue. After 4.5 h, the concentration in the CSF was clearly higher than in blood but was almost completely cleared and lower than the brain tissue concentration after 24 h.
    In contrast to the brain signal hyperintensities, no differences in penetration and distribution into the CSF of healthy rats exist among the marketed GBCAs.
    aEuro cent Gadolinium-based contrast agents can cross the blood-CSF barrier.
    aEuro cent Fluid-attenuated MRI shows GBCA distribution with CSF flow.
    aEuro cent GBCA structure and physicochemical properties do not impact CSF penetration and distribution.
    aEuro cent GBCA clearance from CSF was almost complete within 24 h in rats.
    aEuro cent CSF is a potential pathway of GBCA entry into the brain.

    DOI: 10.1007/s00330-016-4654-2

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  201. Portal Vein Bleeding after Pancreatectomy: Diagnosis and Stent Graft Repair - A Consecutive Case Series

    Suzuki Kojiro, Ebata Tomoki, Komada Tomohiro, Matsushima Masaya, Mizuno Takashi, Igami Tsuyoshi, Sugawara Gen, Yokoyama Yukihiro, Naganawa Shinji, Nagino Masato

    JOURNAL OF THE PANCREAS   Vol. 18 ( 4 ) page: 339 - 344   2017.7

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  202. Progression of mean pulmonary arterial pressure in idiopathic pulmonary fibrosis with mild to moderate restriction Reviewed

    Ryo Teramachi, Hiroyuki Taniguchi, Yasuhiro Kondoh, Masahiko Ando, Tomoki Kimura, Kensuke Kataoka, Atsushi Suzuki, Taiki Furukawa, Koji Sakamoto, Yoshinori Hasegawa

    RESPIROLOGY   Vol. 22 ( 5 ) page: 986 - 990   2017.7

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    Background and objectiveElevation of mean pulmonary arterial pressure (MPAP) is associated with poor prognosis in patients with idiopathic pulmonary fibrosis (IPF), yet the progression of MPAP in patients with IPF has not been sufficiently elucidated. We evaluated serial changes in MPAP and its determinants in patients with IPF with mild to moderate restriction.
    MethodsWe retrospectively reviewed patients with IPF who underwent initial evaluations including right heart catheterization (RHC) in our institute from May 2007 to December 2013 with follow-up RHC at least 1year later. Patients with forced vital capacity (FVC)&lt;50% predicted or those with pulmonary artery wedge pressure&gt;15mm Hg were excluded.
    ResultsA total of 95 patients were included. Median follow-up time of second RHC was 1.8years. MPAP increased significantly at follow-up (from 16.8 to 20.2mm Hg; P&lt;0.001), and annual change in MPAP (MPAP) was 1.8mm Hg/year. In multiple regression analysis, the lowest oxygen saturation (SpO(2) ) at 6-min walk test (6MWT) was an independent predictor of MPAP. When adjusted for age, sex, baseline MPAP and FVC % predicted, MPAP was a significant predictor of mortality (hazard ratio: 1.21; P=0.001).
    ConclusionMPAP was significantly associated with desaturation in the 6MWT, and with increased mortality in patients with IPF with mild to moderate restriction.
    We reviewed patients with idiopathic pulmonary fibrosis with mild to moderate restriction and showed that mean pulmonary arterial pressure (MPAP) was progressive. The lowest oxygen saturation (SpO(2) ) in the 6-min walk test at baseline was an independent predictor of annual change in MPAP.

    DOI: 10.1111/resp.12986

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  203. Effect of Gadolinium Deposition on 18F-FDG PET/CT of Dentate Nucleus and Globus Pallidus. Reviewed

    Shinji Naganawa

    J Nucl Med Technol.   Vol. 45 ( 2 ) page: 173   2017.6

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  204. Letter to Editors: Detection of endolymphatic hydrops using traditional MR imaging sequences. Reviewed

    Shinji Naganawa, Michihiko Sone

    Am J Otolaryngol.   ( 17 ) page: 30378-2   2017.6

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  205. FDG PET/CT Overcomes Discordance Between Clinical and Pathologic TNM Classification of Small-size Primary Lung Cancer: Influence on Postoperative Prognosis. Reviewed

    Hiroyasu Umakoshi, Shingo Iwano, Kohei Yokoi, Shinji Ito, Rintaro Ito, Koji Kawaguchi, Takayuki Fukui, Shinji Naganawa

    Clin Lung Cancer.   ( 17 ) page: 30170-5   2017.6

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  206. Relationship between Contrast Enhancement of the Perivascular Space in the Basal Ganglia and Endolymphatic Volume Ratio. Reviewed

    Toshio Ohashi, Shinji Naganawa, Toshio Katagiri, Kayao Kuno

    Magn Reson Med Sci.     2017.6

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    DOI: 10.2463/mrms.mp.2017-0001.

  207. Comparison of accumulation of F-18-FLT PET/CT with histopathological findings of primary and metastatic lesions of urinary tract tumors

    Kato Katsuhiko, Abe Shinji, Matsuzawa Shinichiro, Mukumoto Ryuto, Odagawa Tetsuro, Naganawa Shinji

    JOURNAL OF NUCLEAR MEDICINE   Vol. 58   page: .   2017.5

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  208. Clinical outcome of definitive radiation therapy for superficial esophageal cancer. Reviewed

    Yutaro Koide, Takeshi Kodaira, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Makoto Itoh, Tetsuya Abe, Kei Muro, Masahiro Tajika, Yasumasa Niwa, Yoshiyuki Itoh, Shinji Naganawa

    Jpn J Clin Oncol.   Vol. 47 ( 5 ) page: 393-400   2017.5

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  209. Portal Vein Bleeding after Pancreatectomy: Diagnosis and Stent Graft Repair - A Consecutive Case Series. Reviewed

    Kojiro Suzuki, Tomoki Ebata, Tomohiro Komada, Masaya Matsushima, Takashi Mizuno, Tsuyoshi Igami, Gen Sugawara, Yukihiro Yokoyama, Shinji Naganawa, Masato Nagino

    Journal of the Pancreas.   Vol. 18 ( 3 ) page: 241-246   2017.5

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  210. Improved HYDROPS: Imaging of Endolymphatic Hydrops after Intravenous Administration of Gadolinium. Reviewed

    Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Michihiko Sone,

    Magn Reson Med Sci.   Vol. 16 ( 4 ) page: 357-361   2017.5

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  211. Structural MRI correlates of amyotrophic lateral sclerosis progression. Reviewed

    Joe Senda, Naoki Atsuta, Hirohisa Watanabe, Epifanio Bagarinao, Kazunori Imai, Daichi Yokoi, Yuichi Riku, Michihito Masuda, Ryoichi Nakamura, Hazuki Watanabe, Mizuki Ito, Masahisa Katsuno, Shinji Naganawa, Gen Sobue

    J Neurol Neurosurg Psychiatry.   Vol. 88 ( 11 ) page: 901-907   2017.5

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  212. Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer. Reviewed

    Rise Miyauchi, Yoshiyuki Itoh, Mariko Kawamura, Akihiro Hirakawa, Kiyosumi Shibata, Hiroaki Kajiyama, Rie Nakahara, Seiji Kubota, Junji Ito, Tohru Okada, Fumitaka Kikkawa, Shinji Naganawa

    Nagoya journal of medical science   Vol. 79 ( 2 ) page: 211 - 220   2017.5

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    The purpose of this retrospective study was to analyze data in patients with stage IB-IIB uterine cervical cancer who were treated with concurrent chemoradiotherapy (CCRT) with high dose cisplatin and fluorouracil as postoperative adjuvant therapy. Between February 2003 and November 2011, 76 patients with FIGO stage IB-IIB cervical cancer were analyzed. Seventy patients were treated with postoperative CCRT and 6 patients were treated with radiation therapy alone. Data related to overall survival (OS), disease-free survival (DFS), toxicity, and failure pattern were analyzed. The median patient age was 45 years (range, 20-80 years). The median follow-up duration was 63 months (range, 10-125 months). Fifty-eight patients (76.3%) had a squamous cell histologic type, 55 patients (72.4%) had lymphovascular invasion, 31 patients (40.8%) had parametrial invasion, and 28 patients (36.8%) had lymph node metastases. Five-year OS and DFS were 96% and 92%, respectively. Five-year DFS in stage IB1 patients was significantly higher than in stage IB2-IIB patients (p = 0.022). Nineteen patients (25%) had grade 3 or 4 neutropenia, 13 patients (17.1%) had grade 3 anemia, and 2 patients (2.6%) had grade 3 thrombocytopenia, but none of these patients died from the disease. Three patients experienced chronic toxicity: one had bladder perforation, one had hydronephrosis, and one experienced ileus. CCRT as postoperative adjuvant therapy resulted in good survival and outcome without severe toxicity.

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  213. Clinical outcome of definitive radiation therapy for superficial esophageal cancer. Reviewed International journal

    Yutaro Koide, Takeshi Kodaira, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Makoto Itoh, Tetsuya Abe, Kei Muro, Masahiro Tajika, Yasumasa Niwa, Yoshiyuki Itoh, Shinji Naganawa

    Japanese journal of clinical oncology   Vol. 47 ( 5 ) page: 393 - 400   2017.5

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    Objective: To analyze the clinical outcome of concurrent chemoradiotherapy in superficial esophageal cancer patients. Methods: We retrospectively analyzed data for 123 patients with superficial esophageal cancer who received external beam radiotherapy without intracavitary brachytherapy plus systemic chemotherapy during 1998-2015. Elective nodal irradiation was not performed. The dosage to planning treatment volume was 60 Gy in 30 fractions. The main outcome measure was overall survival. Results: Patient characteristics were as follows: median age, 66 (41-83) years; male/female ratio, 106/17; squamous cell carcinoma/other, 122/1; cT1a/cT1b, 27/96; cervical esophagus/upper thoracic esophagus/middle thoracic esophagus/lower thoracic esophagus, 7/9/66/41 and concurrent chemoradiotherapy/radiotherapy alone, 100/23. Cisplatin and 5-fluorouracil were the most commonly used agents (85%). At the last follow-up (median 60.5 months), 91 (74%) patients were alive. Complete response was achieved in 116 (94.4%) patients. The 5-year overall survival, progression-free survival and local control rates were 77.0, 46.9 and 62.7%, respectively, similar to that in the elderly patients (P = 0.878, 0.754 and 0.648, respectively). There were 55 failures: 42 local, 10 regional and 3 distant failures. Nine local and seven regional failures developed out-of-field. Thirty-eight local failures (90%) were successfully salvaged, of which 30 (71%) were salvaged via endoscopic removal; only 2 regional failures (20%) were salvaged. Fifteen G3 acute toxicities occurred. One pneumonitis (G3), one pneumothorax (G3) and two pericardial effusion (G2) were the late toxicities observed. There were no G4 toxicities or treatment-related deaths. Conclusions: Concurrent chemoradiotherapy without intracavitary brachytherapy was effective and safe for superficial esophageal cancer, even in elderly patients.

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  214. COPD Assessment Test for measurement of health status in patients with idiopathic pulmonary fibrosis: A cross-sectional study Reviewed

    Toshiaki Matsuda, Hiroyuki Taniguchi, Masahiko Ando, Yasuhiro Kondoh, Tomoki Kimura, Kensuke Kataoka, Koji Sakamoto, Atsushi Suzuki, Taiki Furukawa, Yoshinori Hasegawa

    RESPIROLOGY   Vol. 22 ( 4 ) page: 721 - 727   2017.5

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    Background and objectiveThe COPD Assessment Test (CAT) has been reported to have potential utility for measuring health status of idiopathic pulmonary fibrosis (IPF). Although the CAT has been developed for the assessment of COPD patients, it has not been fully evaluated exclusively in IPF. This study was designed to evaluate the validity of the CAT in IPF.
    MethodsThe clinical data for 106 consecutive subjects with newly diagnosed IPF who completed pulmonary function tests, partial pressure of oxygen in arterial blood (PaO2 ) at rest, 6-min walk test (6MWT), CAT, St George's Respiratory Questionnaire (SGRQ), modified Medical Research Council (mMRC) dyspnoea grade and Hospital Anxiety and Depression Scale (HADS), were analysed. We assessed the validity of the CAT in comparison with the SGRQ.
    ResultsThe present subjects showed mild to moderate restrictive impairment on spirometry. Mean CAT score and total SGRQ were 12.88.0 and 30.817.7, respectively. The concurrent validity of the CAT score in comparison with the SGRQ total score was significant (r=0.72, P&lt;0.001). Internal consistency (Cronbach's =0.869) and repeatability over 3months (intraclass correlation coefficient=0.742) of the CAT were also significant. Single regression analysis showed that the CAT had significant construct validity. In multiple regression analysis, mMRC, PaO2 at rest, minimum SpO(2) during 6MWT and anxiety of HADS were independent predictors for the CAT.
    ConclusionsThe CAT is a valid health status measurement in IPF patients. Multiple regression analysis showed that the CAT was significantly correlated with dyspnoea severity, oxygenation impairment and anxiety.
    The validity of the COPD Assessment Test (CAT) was evaluated exclusively in idiopathic pulmonary fibrosis (IPF) patients in comparison with the St George's Respiratory Questionnaire (SGRQ). The CAT had a significant correlation with SGRQ and was independently predicted by dyspnoea severity, oxygenation impairment and anxiety.

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  215. Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation

    Go Shinji, Go Shiori, Veillon Lucas, Ciampa Maria Grazia, Mauri Laura, Sato Chihiro, Kitajima Ken, Prinetti Alessandro, Sonnino Sandro, Inokuchi Jin-ichi

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 292 ( 17 ) page: 7040 - 7051   2017.4

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    DOI: 10.1074/jbc.M116.771253

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  216. CSF Pulsation Artifacts on ADC Maps Obtained with Readout-segmented EPI.

    Toshio Ohashi, Shinji Naganawa, Mai Kanou, Mitsuru Ikeda

    Magn Reson Med Sci.   Vol. 16 ( 2 ) page: 123-128   2017.4

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    DOI: 10.2463/mrms.mp.2016-0031

  217. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. Reviewed

    Toshiaki Taoka, Yoshitaka Masutani, Hisashi Kawai, Toshiki Nakane, Kiwamu Matsuoka, Fumihiko Yasuno, Toshifumi Kishimoto, Shinji Naganawa

    Jpn. J Radiol.   ( 35 ) page: 172-178   2017.4

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  218. Lack of Contrast Enhancement in a Giant Perivascular Space of the Basal Ganglion on Delayed FLAIR Images: Implications for the Glymphatic System. Reviewed

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka

    Magn Reson Med Sci.   Vol. 16 ( 2 ) page: 89-90   2017.4

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  219. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases. Reviewed

    Toshiaki Taoka, Yoshitaka Masutani, Hisashi Kawai, Toshiki Nakane, Kiwamu Matsuoka, Fumihiko Yasuno, Toshifumi Kishimoto, Shinji Naganawa

    Japanese journal of radiology   Vol. 35 ( 4 ) page: 172 - 178   2017.4

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    PURPOSE: The activity of the glymphatic system is impaired in animal models of Alzheimer's disease (AD). We evaluated the activity of the human glymphatic system in cases of AD with a diffusion-based technique called diffusion tensor image analysis along the perivascular space (DTI-ALPS). MATERIALS AND METHODS: Diffusion tensor images were acquired to calculate diffusivities in the x, y, and z axes of the plane of the lateral ventricle body in 31 patients. We evaluated the diffusivity along the perivascular spaces as well as projection fibers and association fibers separately, to acquire an index for diffusivity along the perivascular space (ALPS-index) and correlated them with the mini mental state examinations (MMSE) score. RESULTS: We found a significant negative correlation between diffusivity along the projection fibers and association fibers. We also observed a significant positive correlation between diffusivity along perivascular spaces shown as ALPS-index and the MMSE score, indicating lower water diffusivity along the perivascular space in relation to AD severity. CONCLUSION: Activity of the glymphatic system may be evaluated with diffusion images. Lower diffusivity along the perivascular space on DTI-APLS seems to reflect impairment of the glymphatic system. This method may be useful for evaluating the activity of the glymphatic system.

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  220. Magnetic resonance imaging evaluation of endolymphatic hydrops andpost-operative findings in cases with otosclerosis.

    Michihiko Sone, Tadao Yoshida, Satofumi Sugimoto, Kyoko Morimoto, Yuriko Okazaki, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima

    Acta Otolaryngol.   Vol. 137 ( 3 ) page: 242-245   2017.3

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  221. Do gadolinium-based contrast agents affect the 18F-FDG PET/CT uptake in the dentate nucleus and the globus pallidus? Reviewed

    Shinji Naganawa

    J Nucl Med Technol.     2017.3

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    DOI: 10.2967/jnmt.116.187591

  222. Magnetic resonance imaging evaluation of endolymphatic hydrops andpost-operative findings in cases with otosclerosis Reviewed

    Michihiko Sone, Tadao Yoshida, Satofumi Sugimoto, Kyoko Morimoto, Yuriko Okazaki, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima

    ACTA OTO-LARYNGOLOGICA   Vol. 137 ( 3 ) page: 242 - 245   2017.3

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    Conclusions: The presence of endolymphatic hydrops (EH) in the vestibule on magnetic resonance imaging (MRI) might be a high-risk factor for complications in cases that are candidates for stapes surgery.
    Objective: Pre-operative detection of EH could be valuable in cases that are candidates for stapes surgery to prevent unpredictable complications following surgery. Pre-operative MRI findings and post-operative findings following stapes surgery were compared to evaluate the efficacy of such MRI evaluation for the management of cases with otosclerosis.
    Subjects and methods: Sixteen cases who underwent pre-operative evaluation by 3T MRI performed 4h after intravenous injection of gadolinium and stapes surgery for otosclerosis were recruited. Imaging data concerning the degree of EH in the vestibule and cochlea were compared with post-operative clinical findings for all cases.
    Results: Mild EH in the cochlea or the vestibule was observed in eight ears and one ear, respectively, whereas one ear showed significant EH both in the cochlea and the vestibule. The post-operative course was uneventful in 12 of 14 cases with no EH in the vestibule, and the other two cases had a short period of dizziness, but two cases with EH in the vestibule had a long period of dizziness.

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  223. Modulation of immunological activity on macrophages induced by diazinon Reviewed

    Nanako Ogasawara, Miyoko Matsushima, Nami Kawamura, Kazuko Atsumi, Takehiro Yamaguchi, Haruka Ochi, Yuto Kusatsugu, Sayaka Oyabu, Naozumi Hashimoto, Yoshinori Hasegawa, Jun Ueyama, Tsutomu Kawabe

    TOXICOLOGY   Vol. 379   page: 22 - 30   2017.3

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    Diazinon is an organophosphorus (OP) insecticide and is widely used not only in agriculture but also homes and garden in Japan. Diazinon has been reported to increase TNF-alpha production in rat serum and brain, suggesting that it can modify the proinflammatory response. In this study, we investigated the effects of diazinon on macrophage functions, such as cytokine production, reactive oxygen species (ROS) generation, cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) expressions, cell-surface molecule expressions, and phagocytosis in RAW264.7 cells. In RAW264.7 cells, diazinon induced the production of TNF-alpha and IL-6. Diazinon induced ROS generation and the expressions of COX-2, iNOS, and cell-surface molecules CD40, CD86, and MI-IC class II, but reduced phagocytic activity in RAW264.7 cells. ERIC and p38, but not JNK and p65 were involved in diazinon-induced IL-6 expression in RAW264.7 cells. We also examined these proinflammatory responses in bone marrow-derived macrophages (BMDM) and bronchoalveolar lavage fluid (BALF) cells. These results suggested that diazinon can activate macrophages and enhance inflammatory responses. (C) 2017 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.tox.2017.01.014

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    Other Link: http://orcid.org/0000-0003-0660-2726

  224. Emerging neuroradiological topics in journals from related societies. Reviewed

    Yukunori Korogi, Shinji Naganawa

    Jpn. J Radiol.   Vol. 35 ( 1 ) page: 1-2   2017.2

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  225. Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer. Reviewed

    Rise Miyauchi, Yoshiyuki Itoh, Mariko Kawamura, Akihiro Hirakawa, Kiyosumi Shibata, Hiroaki Kajiyama, Rie Nakahara, Seiji Kubota, Junji Ito, Tohru Okada, Fumitaka Kikkawa, Shinji Naganawa

    Nagoya J Med Sci.   Vol. 79 ( 2 ) page: 211-220   2017.2

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  226. Imaging of the endolymphatic space in patients with Ménière's disease. Reviewed

    Tadao Yoshida, Satofumi Sugimoto, Masaaki Teranishi, Hironao Otake, Masahiro Yamazaki, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

    Auris Nasus Larynx.   ( 17 ) page: 30142-6   2017.2

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  227. Thoracic Temporal Subtraction Three Dimensional Computed Tomography (3D-CT): Screening for Vertebral Metastases of Primary Lung Cancers. Reviewed International journal

    Shingo Iwano, Rintaro Ito, Hiroyasu Umakoshi, Takatoshi Karino, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    PloS one   Vol. 12 ( 1 ) page: e0170309   2017.1

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    PURPOSE: We developed an original, computer-aided diagnosis (CAD) software that subtracts the initial thoracic vertebral three-dimensional computed tomography (3D-CT) image from the follow-up 3D-CT image. The aim of this study was to investigate the efficacy of this CAD software during screening for vertebral metastases on follow-up CT images of primary lung cancer patients. MATERIALS AND METHODS: The interpretation experiment included 30 sets of follow-up CT scans in primary lung cancer patients and was performed by two readers (readers A and B), who each had 2.5 years' experience reading CT images. In 395 vertebrae from C6 to L3, 46 vertebral metastases were identified as follows: osteolytic metastases (n = 17), osteoblastic metastases (n = 14), combined osteolytic and osteoblastic metastases (n = 6), and pathological fractures (n = 9). Thirty-six lesions were in the anterior component (vertebral body), and 10 lesions were in the posterior component (vertebral arch, transverse process, and spinous process). The area under the curve (AUC) by receiver operating characteristic (ROC) curve analysis and the sensitivity and specificity for detecting vertebral metastases were compared with and without CAD for each observer. RESULTS: Reader A detected 47 abnormalities on CT images without CAD, and 33 of them were true-positive metastatic lesions. Using CAD, reader A detected 57 abnormalities, and 38 were true positives. The sensitivity increased from 0.717 to 0.826, and on ROC curve analysis, AUC with CAD was significantly higher than that without CAD (0.849 vs. 0.902, p = 0.021). Reader B detected 40 abnormalities on CT images without CAD, and 36 of them were true-positive metastatic lesions. Using CAD, reader B detected 44 abnormalities, and 39 were true positives. The sensitivity increased from 0.783 to 0.848, and AUC with CAD was nonsignificantly higher than that without CAD (0.889 vs. 0.910, p = 0.341). Both readers detected more osteolytic and osteoblastic metastases with CAD than without CAD. CONCLUSION: Our temporal 3D-CT subtraction CAD software easily detected vertebral metastases on the follow-up CT images of lung cancer patients regardless of the osteolytic or osteoblastic nature of the lesions.

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  228. Endolymphatic hydrops in patients with unilateral and bilateral Meniere's disease.

    Kyoko Morimoto, Tadao Yoshida, Saiko Sugiura, Masahiro Kato, Ken Kato, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

    Acta Otolaryngol.   Vol. 137 ( 1 ) page: 23-28   2017.1

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  229. Structure of the Medullary Veins of the Cerebral Hemisphere and Related Disorders. Reviewed

    Toshiaki Taoka, Akio Fukuisumi, Toshiteru Miyasaka, Hisashi Kawai, Toshiki Nakane, Kimihiko Kichikawa, Shinji Naganawa

    Radiographics.   Vol. 37 ( 1 ) page: 281-297   2017.1

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  230. Thoracic Temporal Subtraction Three Dimensional Computed Tomography (3D-CT): Screening for Vertebral Metastases of Primary Lung Cancers. Reviewed

    Shingo Iwano, Rintaro Ito, Hiroyasu Umakoshi, Takatoshi Karino, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    PLoS One.   Vol. 12 ( 1 ) page: e0170309   2017.1

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  231. Emerging neuroradiological topics in journals from related societies Reviewed

    Yukunori Korogi, Shinji Naganawa

    JAPANESE JOURNAL OF RADIOLOGY   Vol. 35 ( 1 ) page: 1 - 2   2017.1

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    DOI: 10.1007/s11604-016-0600-0

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  232. Endolymphatic hydrops in patients with unilateral and bilateral Meniere's disease Reviewed

    Kyoko Morimoto, Tadao Yoshida, Saiko Sugiura, Masahiro Kato, Ken Kato, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima, Michihiko Sone

    ACTA OTO-LARYNGOLOGICA   Vol. 137 ( 1 ) page: 23 - 28   2017.1

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    Conclusion: All definite Meniere's disease (MD) had endolymphatic hydrops (EH) at least in the cochlea or the vestibule. Symptoms of MD may appear after formation of EH. It is assumed that the probability of immediate progression to bilateral MD from unilateral MD is very low in patients without EH on the non-affected side.
    Objective: To evaluate the EH on both sides in patients with unilateral and bilateral MD, and to investigate factors with progression to bilateral MD including the degree of EH, hearing level, and the duration of MD.
    Patients and methods: The study included 29 patients with unilateral definite MD and 12 patients with bilateral definite MD. The endolymphatic space size was visualized by using 3-Tesla magnetic resonance imaging.
    Results: All patients with unilateral and bilateral MD had significant or mild EH at least in the cochlea or the vestibule on the affected side. On the non-affected side, EH was not observed at all in eight patients, but asymptomatic EH was observed in the cochlea in 14 patients and in the vestibule in 16 patients. There was no relationship between the EH on the non-affected side and the duration of MD.

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  233. Visualization of Middle Ear Ossicles in Elder Subjects with Ultra-short Echo Time MR Imaging.

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Kojiro Suzuki, Shingo Iwano, Hiroko Satake, David Grodzki

    Magn Reson Med Sci.   Vol. 16 ( 2 ) page: 93 - 97   2017

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    DOI: 10.2463/mrms.mp.2015-0171

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  234. Gd-based Contrast Enhancement of the Perivascular Spaces in the Basal Ganglia.

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka

    Magn Reson Med Sci.   Vol. 16 ( 1 ) page: 61 - 65   2017

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    DOI: 10.2463/mrms.mp.2016-0039

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  235. Lack of Contrast Enhancement in a Giant Perivascular Space of the Basal Ganglion on Delayed FLAIR Images: Implications for the Glymphatic System. Reviewed

    Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 16 ( 2 ) page: 89 - 90   2017

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    DOI: 10.2463/mrms.ci.2016-0114

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  236. Improved HYDROPS: Imaging of Endolymphatic Hydrops after Intravenous Administration of Gadolinium. Reviewed

    Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Michihiko Sone

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   Vol. 16 ( 4 ) page: 357 - 361   2017

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    To improve the imaging protocol for the evaluation of endolymphatic hydrops after intravenous administration of a gadolinium-based contrast agent, we modified our previously reported hybrid of reversed image of positive endolymph signal and native image of positive perilymph signal (HYDROPS) method. Although the scan time of the new protocol was half that of the previous one, there were no significant differences between two protocols in the mean contrast noise ratio between the endolymph and perilymph and the area ratio of the endolymph size values in nine patients.

    DOI: 10.2463/mrms.tn.2016-0126

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  237. Detection of endolymphatic hydrops using traditional MR imaging sequences

    Naganawa Shinji, Sone Michihiko

    AMERICAN JOURNAL OF OTOLARYNGOLOGY   Vol. 38 ( 5 ) page: 637-638   2017

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  238. Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall: A pilot study. Reviewed International journal

    Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa

    PloS one   Vol. 12 ( 9 ) page: e0185532   2017

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    OBJECTIVES: To quantify the imaging findings of patients with interstitial pneumonia (IP) and emphysema using three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall, and compare the results to visual assessment of IP and each patient's diffusing capacity of the lungs for carbon monoxide (DLco). METHODS: We retrospectively reviewed the axial CT findings and pulmonary function test results of 95 patients with lung cancer (72 men and 23 women, aged 45-84 years) with or without IP, as follows: non-IP (n = 47), mild IP (n = 31), and moderate IP (n = 17). The 3D-cHRCT images of the lung at a 1-cm depth from the chest wall were reconstructed automatically using original software; total area (TA), high-attenuation area (HAA) >-500 HU, and low-attenuation area (LAA) <-950 HU were calculated on a workstation. The %HAA and %LAA were calculated as follows: [Formula: see text], and [Formula: see text]. RESULTS: The %HAA and %LAA respective values were 3.2±0.9 and 27.7±8.2, 3.9±1.2 and 27.6±5.9, and 6.9±2.2 and 25.4±8.7 in non-IP, mild IP, and moderate IP patients, respectively. There were significant differences in %HAA between the 3 groups of patients (P<0.001), but no differences in %LAA (P = 0.558). Multiple linear regression analysis revealed that %HAA and %LAA were negatively correlated with predicted DLco (standard partial regression coefficient [b*] = -0.453, P<0.001; b* = -0.447, P<0.001, respectively). CONCLUSIONS: The %HAA and %LAA values computed using 3D-cHRCT were significantly correlated with DLco and may be important quantitative parameters for both IP and emphysema.

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  239. Structure of the Medullary Veins of the Cerebral Hemisphere and Related Disorders Reviewed

    Toshiaki Taoka, Akio Fukusumi, Toshiteru Miyasaka, Hisashi Kawai, Toshiki Nakane, Kimihiko Kichikawa, Shinji Naganawa

    RADIOGRAPHICS   Vol. 37 ( 1 ) page: 280 - 296   2017

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    Deep medullary veins drain into subependymal veins with four convergence zones and show parallel distribution patterns adjacent to the body or inferior horn and a radial pattern in the frontal horn or trigon of the lateral ventricle. As white matter imaging develops such as diffusion tensor imaging or susceptibility-weighted imaging, requirements for understanding of white matter structures are increasing, not only for understanding of neuronal tracts but also for that of other structures including the fine anatomy of white matter vessels. Some disorders are related to deep medullary veins and show characteristic distributions of the lesions indicating the relationship to the medullary veins. When lesions show a parallel or radial distribution pattern in the certebral deep white matter, disorders related to deep medullary veins should be considered for differential diagnosis. In this review, we discuss disorders related to deep medullary veins, including (a) anomalies of the medullary veins, (b) hemorrhagic disorders related to the medullary veins (diffuse vascular injury due to high-energy trauma, deep medullary vein engorgement/thrombosis in neonates), (c) inflammatory changes that spread along the medullary veins, (d) neoplasms within the medullary veins, and (e) metabolic changes that lead to altered visualization of medullary veins. Understanding the anatomic structure of medullary veins in the cerebral hemisphere and becoming familiar with disorders in which the medullary veins play a major role in disease development may be helpful in the interpretation of brain images. (C) RSNA, 2017

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  240. CSF Pulsation Artifacts on ADC Maps Obtained with Readout-segmented EPI

    Ohashi Toshio, Naganawa Shinji, Kanou Mai, Ikeda Mitsuru

    MAGNETIC RESONANCE IN MEDICAL SCIENCES   Vol. 16 ( 2 ) page: 123-128   2017

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    DOI: 10.2463/mrms.mp.2016-0031

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  241. A multicenter survey of stage T1 glottic cancer treated with radiotherapy delivered in 2.25-Gy fractions in clinical practice: An initial 5-year analysis.

    Yoshiyuki Itoh, Seiji Kubota, Mariko Kawamura, Yoshihito Nomoto, Takayuki Murao, Kouji Yamakawa, Shunichi Ishihara, Naoki Hirasawa, Akiko Asano, Shigeo Yanagawa, Shinji Naganawa

    Nagoya J. Med. Sci.   Vol. 78 ( 4 ) page: 399-406   2016.12

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  242. Active brain changes after initiating fingolimod therapy in multiple sclerosis patients using individual voxel-based analyses for diffusion tensor imaging. Reviewed

    Joe Senda, Hirohisa Watanabe, Kuniyuki Endo, Keizo Yasui, Yasuhiro Hawsegawa, Noritaka Yoneyama, Takashi Tsuboi, Kazuhiro Hara, Mizuki Ito, Naoki Atsuta, Bagarinao Epifanio Jr, Masahisa Katsuno, Shinji Naganawa, Gen Sobue

    Nagoya J Med Sci.   Vol. 78 ( 4 ) page: 455-463   2016.12

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  243. Magnetic resonance imaging of cardiac sarcoidosis: an evaluation of the cardiac segments and layers that exhibit late gadolinium enhancement. Reviewed

    Tomohiro Komada, Kojiro Suzuki, Hiroaki Ishiguchi, Hisashi Kawai, Takahiro Okumura, Akihiro Hirashiki, Shinji Naganawa

    Nagoya J. Med. Sci.   Vol. 78   page: 437-446   2016.11

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  244. Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum.

    Michihito Masuda, Joe Senda, Hirohisa Watanabe, Bagarinao Epifanio, Yasuhiro Tanaka, Kazunori Imai, Yuchi Riku, Yuanzhe Li, Ryoichi Nakamura, Mizuki Ito, Shinsuke Ishigaki, Naoki Atsuta, Haruki Koike, Katsuno Masahisa, Nobutaka Hattori, Shinji Naganawa, Gen Sobue

    Amyotroph Lateral Scler Frontotemporal Degener.   Vol. 17 ( 7-8 ) page: 571-579   2016.10

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  245. Ⅳ ISMRMから読み解くMRI最新動向 1.臨床の視点から見たISMRM2016のトピックス―頭頸部領域を中心に

    長縄慎二

    INNERVISION   Vol. 31 ( 9 ) page: 66-68   2016.9

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  246. Impact of Thin-Section Computed Tomography-Determined Combined Pulmonary Fibrosis and Emphysema on Outcomes Among Patients With Resected Lung Cancer Reviewed

    Naozumi Hashimoto, Shingo Iwano, Koji Kawaguchi, Takayuki Fukui, Koichi Fukumoto, Shota Nakamura, Shunsuke Mori,Koji Sakamoto, Kenji Wakai, Kohei Yokoi, Yoshinori Hasegawa

    Ann Thorac Surg.   Vol. 102 ( 2 ) page: 440-447   2016.8

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  247. BOOK REVIEW:頭頸部の臨床画像診断学 改訂第3版

    長縄慎二

    画像診断   Vol. 36 ( 8 ) page: 799   2016.7

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  248. Diffusion tensor studies and voxel-based morphometry of the temporal lobe to determine the cognitive prognosis in cases of Alzheimer's disease and mild cognitive impairment: Do white matter changes precede gray matter changes?

    Toshiaki Taoka, Fumihiko Yasuno, Masayuki Morikawa, Makoto Inoue, Kuniaki Kiuchi, Soichiro Kitamura, Kiwamu Matsuoka, Toshifumi Kishimoto, Kimihiko Kichikawa, Shinji Naganawa

    SpringerPlus.   Vol. 5 ( 1 ) page: 1023   2016.7

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  249. Evaluation of locoregional invasiveness of small-sized non-small cell lung cancers by enhanced dual-energy computed tomography. Reviewed

    Hironori Shimamoto, Shingo Iwano, Hiroyasu Umakoshi, Koji Kawaguchi, Shinji Naganawa

    Cancer Imaging.   Vol. 16 ( 1 ) page: 18   2016.7

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  250. Characterization of stochastic noise and post-irradiation density growth for reflective-type radiochromic film in therapeutic photon beam dosimetry. Reviewed

    Takeshi Kamomae, Masataka Oita, Naoki Hayashi, Motoharu Sasaki, Hideki Aoyama, Hiroshi Oguchi, Mariko Kawamura, Hajime Monzen, Yoshiyuki Itoh, Shiniji Naganawa

    Phys Med   Vol. 32   page: 1314-1320   2016.7

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  251. Late Rectal Toxicity from Image-guided Intensity Modulated Radiotherapy for Prostate Cancer.

    Maki S, Itoh Y, Kubota S, Okada T, Nakahara R, Ito J, Kawamura M, Kamomae T, Naganawa S, Yoshino Y, Gotoh M, Ikeda M

    Anticancer Res.   Vol. 36 ( 6 ) page: 2967-2973   2016.6

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  252. Contrast-enhanced magnetic resonance pancreatography with gadoteridol by heavily T2-weighted three-dimensional fluid-attenuated inversion recovery: preliminary results in healthy subjects.

    Kojiro Suzuki, Shinji Naganawa, Naohiro Furuhashi, Masahiro Yamazaki, Hiroshi Ogawa and Hisashi Kawai

    Nagoya J. Med. Sci.   Vol. 78 ( 2 ) page: 175-181   2016.5

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  253. Meniere's disease.

    Tsutomu Nakashima, Ilmari Pyykko, Megan A. Arroll, Margaretha L. Casselbrant, Carol A. Foster, Nauman F. Manzoor, Cliff A. Megerian, Shinji Naganawa, Yi Ho Young

    Nat Rev Dis Primers.     2016.5

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    DOI: 10.1038/nrdp.2016.28.

  254. Application of histogram analysis for the evaluation of vascular permeability in glioma by the K2 parameter obtained with the dynamic susceptibility contrast method: Comparisons with Ktrans obtained with the dynamic contrast enhance method and cerebral blood volume.

    Toshiaki Taoka, Hisashi Kawai , Toshiki Nakane , Saeka Hori, Tomoko Ochi, Toshiteru Miyasaka, Masahiko Sakamoto, Kimihiko Kichikawa, Shinji Naganawa

    Magn Reson Imaging.   Vol. 34 ( 7 ) page: 896-901   2016.4

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  255. Comparison of the multidetector-row computed tomography findings of IgG4-related sclerosing cholangitis and extrahepatic cholangiocarcinoma.

    Yata Masaki, Suzuki Kojiro, Furuhashi Naohiro, Kawakami K, Kawai Y, Naganawa Shinji

    Clin Radiol.   Vol. 71 ( 3 ) page: 203-210   2016.3

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  256. Time Course of Diffusion Kurtosis in Cerebral Infarctions of Transient Middle Cerebral Artery Occlusion Rat Model.

    Toshiaki Taoka, Masayuki Fujioka, Yuto Kashiwagi, Atsushi Obata, Takemi Rokugawa, Masaaki Hori, Yoshitaka Masutani, Shigeki Aoki, Shinji Naganawa, Kohji Abe

    J Stroke Cerebrovasc Dis.   Vol. 25 ( 3 ) page: 610-617   2016.3

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  257. 非正規分布拡散画像の評価方法の開発

    田岡俊昭、長縄慎二、川井 恒

    脳とこころの研究センター 脳疾患克服に向けた次世代創訳開発のためのコホート・コンソーシアム型研究拠点形成 平成27年度活動報告書     page: 32   2016.3

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  258. Simple Estimation of the Endolymphatic Volume Ratio after Intravenous Administration of a Single-dose of Gadolinium Contrast.

    Shinji Naganawa, Mai Kanou, Toshio Ohashi, Kayao Kuno, Michihiko Sone

    Magn Reson Med Sci.     2016.3

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    DOI: 10.2463/mrms.mp.2015-0175

  259. Cochlear Lymph Fluid Signal Increase in Patients with Otosclerosis after Intravenous Administration of Gadodiamide.

    Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Kojiro Suzuki, Shingo Iwano, Hiroko Satake, Michihiko Sone, Mitsuru Ikeda

    Magn Reson Med.     2016.2

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    DOI: 10.2463/mrms.mp.2015-0121

  260. 夢について

    長縄慎二

    健康文化   Vol. 50   page: 77-79   2015.12

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  261. White Matter Abnormality Correlates with Developmental and Seizure Outcomes in West Syndrome of Unknown Etiology.

    Jun Natsume, Chikako Ogawa, Tatsuya Fukasawa, Hiroyuki Yamamoto, Naoko Ishihara, Yoko Sakaguchi, Yuji Ito, Tomoya Takeuchi, Yoshiki Azuma, Naoki Ando, Tetsuo Kubota, Takeshi Tuji, Hisashi Kawai, Shinji Naganawa, Hiroyuki Kidokoro

    AJNR Am J Neuroradiol.     2015.11

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    DOI: 10.3174/ajnr.A4589.

  262. Heavily T2-Weighted 3D-FLAIR Improves the Detection of Cochlear Lymph Fluid Signal Abnormalities in Patients with Sudden Sensorineural Hearing Loss.

    Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Kojiro Suzuki, Shingo Iwano, Hiroko Satake, Michihiko Sone, Mitsuru Ikeda

    Magn Reson Med Sci.     2015.11

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    DOI: 10.2463/mrms.mp.2015-0065

  263. Endolymphatic hydrops in superior canal dehiscence and large vestibular aqueduct syndromes.

    Michihiko Sone, Tadao Yoshida, Kyoko Morimoto , Masaaki Teranishi, Tsutomu Nakashima, Shinji Naganawa

    Laryngoscope.     2015.11

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    DOI: 10.1002/lary.25747.

  264. Changes in endolymphatic hydrops in patients with Ménière's disease treated conservatively for more than 1 year.

    Suga K, Kato M, Yoshida T, Nishio N, Nakada T, Sugiura S, Otake H, Kato K, Teranishi M, Sone M, Naganawa S, Nakashima T.

    Acta Otolaryngol.   Vol. 135 ( 9 ) page: 866-870   2015.9

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  265. Ⅷ ISMRMから読み解くMRI最新動向 1.臨床の視点から見たISMRM2015のトピックス 1)頭頸部領域

    長縄慎二

    INNERVISION   Vol. 30 ( 9 ) page: 63-65   2015.9

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  266. CASE OF THE MONTH―THE KEY TO Case of August―(8月号掲載のCASE OF THE MONTHの解答)

    岩野信吾、長縄慎二

    画像診断   Vol. 35 ( 12 ) page: 1442-1444   2015.9

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  267. Evaluation of lung cancer by enhanced dual-energy CT: association between three-dimensional iodine concentration and tumour differentiation.

    Shingo Iwano, Rintaro Ito, Hiroyasu Umakoshi, Shinji Ito, Shinji Naganawa

    Br J Radiol.     page: in press   2015.9

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    DOI: 10.1259/bjr.20150224

  268. How the Non-attending Brain Hears Its Owner's Name.

    Toshiki Nakane, Makoto Miyakoshi, Toshiharu Nakai, Shinji Naganawa

    Cereb Cortex.     page: in press   2015.9

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    DOI: 10.1093/cercor/bhv184

  269. Correlation between FDG-PET/CT findings and solid type non-small cell cancer prognostic factors: are there differences between adenocarcinoma and squamous cell carcinoma?

    Rintaro Ito, Shingo Iwano, Mariko Kishimoto, Shinji Ito, Katsuhiko Kato, Shinji Naganawa

    Ann Nucl Med.     page: in press   2015.9

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    DOI: 10.1007/s12149-015-1025-z

  270. A Randomized, Double-Blind Pilot Trial of Hydrolyzed Rice Bran versus Placebo for Radioprotective Effect on Acute Gastroenteritis Secondary to Chemoradiotherapy in Patients with Cervical Cancer.

    Yoshiyuki Itoh, Mika Mizuno, Mitsuru Ikeda, Rie Nakahara, Seiji Kubota, Junji Ito, Tohru Okada, Mariko Kawamura, Fumitaka Kikkawa, Shinji Naganawa

    Evidence-Based Complementary and Alternative Medicine.     page: in press   2015.9

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    DOI: Article ID:974390

  271. Ossicular Anomaly and Endolymphatic Hydrops as Risk Factors for Complications after Ossiculoplasty. Reviewed

    Norihiko Inagaki, Tadao Yoshida, Michihiko Sone, Satofumi Sugimoto, Hironao Otake, Masaaki Teranishi, Shinji Naganawa, Tsutomu Nakashima

    Austin J Radiol   Vol. 2 ( 5 ) page: 1029   2015.8

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  272. Background parenchymal enhancement in preoperative breast MRI.

    Satoko Kohara, Satoko Ishigaki, Hiroko Satake, Akiko Kawamura, Hisashi Kawai, Toyone Kikumori and Shinji Naganawa

    Nagoya J Med Sci   Vol. 77 ( 3 ) page: 373-382   2015.8

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  273. Prediction of background parenchymal enhancement on breast MRI using mammography, ultrasonography, and diffusion-weighted imaging.

    Akiko Kawamura, Hiroko Satake, Satoko Ishigaki, Mitsuru Ikeda, Reiko Kimura, Kazuhiro Shimamoto and Shinji Naganawa

    Nagoya J Med Sci   Vol. 77 ( 3 ) page: 425-437   2015.8

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  274. CASE OF THE MONTH―THE KEY TO Case of July―(7月号掲載のCASE OF THE MONTHの解答)

    佐竹弘子、石垣聡子、長縄慎二

    画像診断   Vol. 35 ( 10 ) page: 1316-1318   2015.8

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  275. CASE OF THE MONTH―CASE OF September―

    鈴木耕次郎、小川 浩、長縄慎二

    画像診断   Vol. 35 ( 10 ) page: 1315   2015.8

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  276. 2.解剖・正常変異―部位別の鑑別診断―Q2.読影に必要な脳神経の解剖について簡単に教えてください。   

    長縄慎二

    画像診断   Vol. 35 ( 10 ) page: 1211-1213   2015.8

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  277. Pancreatic neuroendocrine tumors containing areas of iso- or hypoattenuation in dynamic contrast-enhanced computed tomography: Spectrum of imaging findings and pathological grading. Reviewed

    Ryota Hyodo, Kojiro Suzuki, Hiroshi Ogawa, Tomohiro Komada, Shinji Naganawa

    Eur J Radiol.     2015.8

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    DOI: 10.1016/j.ejrad.2015.08.014.

  278. A phase I/II trial of intraoperative breast radiotherapy in an Asian population: 5-year results of local control and cosmetic outcome.

    Kawamura M, Itoh Y, Sawaki M, Kikumori T, Tsunoda N, Kamomae T, Kubota S, Okada T, Nakahara R, Ito J, Hayashi H, Naganawa S.

    Radiat Oncol.   Vol. 10 ( 150 )   2015.7

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    DOI: 10.1186/s13014-015-0469-6.

  279. CASE OF THE MONTH―CASE OF August―

    岩野信吾、長縄慎二

    画像診断   Vol. 35 ( 9 ) page: 1147   2015.7

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  280. Stent-graft treatment for extrahepatic portal vein hemorrhage after pancreaticoduodenectomy.

    Suzuki K, Igami T, Komada T, Mori Y, Yokoyama Y, Ebata T, Naganawa S, Nagino M.

    Acta Radiol Open.   Vol. 4 ( 6 ) page: 1-4   2015.6

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  281. CASE OF THE MONTH―CASE OF July―

    佐竹弘子、石垣聡子、長縄慎二

    画像診断   Vol. 35 ( 8 ) page: 1007   2015.6

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  282. Differentiation of focal-type autoimmune pancreatitis from pancreatic carcinoma: assessment by multiphase contrast-enhanced CT. Reviewed

    Naohiro Furuhashi, Kojiro Suzuki, Yusuke Sakurai, Mitsuru Ikeda, Yuichi Kawai, Shinji Naganawa

    Eur Radiol   Vol. 25 ( 5 ) page: 1366-1374   2015.5

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  283. 今後MRI診断はいかなる領域を拓いていくべきか

    長縄慎二

    新医療   Vol. 486 ( 6 ) page: 28-31   2015.5

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  284. Cerumen impaction shown by brain magnetic resonance imaging in patients with cognitive impairment. Reviewed

    Tsutomu Nakashima, Saiko Sugiura, Shinji Naganawa, Minori Yasue, Yoshitaka Inui, Takeshi Sakurai, Yasue Uchida, Michihiko Sone, Masaaki Teranishi, Tadao Yoshida, Kengo Ito, Kenji Toba

    Geriatr Gerontol Int.     2015.5

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    DOI: 10.1111/ggi.12529.

  285. 乳がんにおける画像診断の最新トピックス

    石垣聡子、佐竹弘子、川井 恒、長縄慎二

    東海核医学セミナー症例集:2-5     page: 2-5   2015.5

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  286. Critical evaluation of a prospective study of concurrent chemoradiotherapy with s-1 for early glottic carcinoma. Reviewed

    Kana Kimura, Yoshiyuki Itoh, Tohru Okada, Rie Nakahara, Mariko Kawamura, Seiji Kubota, Junji Itoh, Mariko Hiramatsu, Yasushi Fujimoto, Takashi Shibata, Shinji Naganawa

    ANTICANCER RESEARCH.   Vol. 35 ( 4 ) page: 2385-2390   2015.4

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  287. 胆道癌の最新の画像診断 MDCT,EOM-MRI,PET(Recent advances in diagnostic imaging of biliary carcinoma: MDCT,EOB-MRI and PET)

    鈴木耕次郎、古橋尚博、小川 浩、長縄慎二

    消化器外科   Vol. 38 ( 5 ) page: 765-771   2015.4

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  288. 胆管癌と胆管炎

    鈴木耕次郎、古橋尚博、小川 浩、長縄慎二

    画像診断   Vol. 35 ( 6 ) page: 699-711   2015.4

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  289. アイソトープと核医学

    長縄慎二

    名古屋大学アイソトープ総合センターTRACER   Vol. 57   page: 1-2   2015.3

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  290. The Technical and Clinical Features of 3D-FLAIR in Neuroimaging. Reviewed

    Shinji Naganawa

    Magn Reson Med Sci.   Vol. 14 ( 2 ) page: 93-106   2015.3

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    DOI: 10.2463/mrms.2014-0132

  291. 放射線科活動年次報告

    川井 恒、長縄慎二

    脳とこころの研究センター 脳疾患克服に向けた次世代創薬開発のためのコホート・コンソーシアム型研究拠点形成 平成26年度活動報告書     page: 34   2015.3

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  292. Ratio of Vestibular Endolymph in Patients with Isolated Lateral Semicircular Canal Dysplasia. Reviewed

    Shinji Naganawa, Hisashi Kawai, Michihiko Sone, Mitsuru Ikeda

    Magn Reson Med Sci.     2015.3

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    DOI: 10.2463/mrms.2014-0112

  293. Volume Quantification of Endolymph after Intravenous Administration of a Single Dose of Gadolinium Contrast Agent: Comparison of 18- versus 8-minute Imaging Protocols. Reviewed

    Shinji Naganawa, Toshio Ohashi, Mai Kanou, Kayao Kuno, Michihiko Sone, Mitsuru Ikeda

    Magn Reson Med Sci.     2015.3

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    DOI: 10.2463/mrms.2014-0118

  294. 内耳の造影MRIによる内リンパ水腫画像                           -その撮像と評価について、いま放射線科医が知っておくべきこと- Reviewed

    長縄慎二

    画像診断    Vol. 35 ( 2 ) page: 278-289   2015.2

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  295. Patient with an SLC26A4 gene mutation who had low-frequency sensorineural hearing loss and endolymphatic hydrops Reviewed

    Tadao Yoshida, Michihiko Sone, Shinji Naganawa, Tsutomu Nakashima

    The Journal of Laryngology & Otology     page: 1-3   2015

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  296. 健康づくり

    長縄慎二

    健康文化   Vol. 49   page: 1   2014.12

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  297. 乳がんとマンモグラフィ

    長縄慎二

    名大病院 かわらばん     page: 4   2014.10

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  298. 私を変えたこの論文【14】

    長縄慎二

    臨床画像   Vol. 30 ( 10 ) page: 1158-1161   2014.10

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  299. Ability of 18-fludeoxyglucose positron emission tomography/CT to detect incidental cancer. Reviewed

    Y Sone, A Sobajima, T Kawachi, S Kohara, K Kato, Shinji Naganawa

    Br J Radiol. (87) 1042   Vol. 87 ( 1042 )   2014.10

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    DOI: 10.1259/bjr.20140030.

  300. 日常診療にすぐに役立つCT/MRIの基礎と活用法-中枢神経系疾患- 序論

    長縄慎二

    日獨医報   Vol. 59 ( 2 ) page: 4   2014.10

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  301. Quiet Suite 臨床編(2) qPETRA/qRESOLVEの使用経験と有用性

    川井 恒、長縄慎二

    INNERVISION   Vol. 29 ( 9 ) page: 46-47   2014.9

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  302. 臨床の立場から見たISMRM2014のトピックス

    長縄慎二

    INNERVISION   Vol. 29 ( 9 ) page: 67-69   2014.9

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  303. 3D Real Inversion Recovery MR Imaging for the Visualization of Endolymphatic Hydrops. Reviewed

    Shinji Naganawa, M Sone

    AJNR Am J Neuroradiol.     2014.9

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    DOI: 10.3174/ajnr.A4126

  304. VISUALIZATION OF BRAIN WHITE MATTER TRACTS USING HEAVILY T2-WEIGHTED THREE-DIMENSIONAL FLUID-ATTENUATED INVERSION-RECOVERY MAGNETIC RESONANCE IMAGING Reviewed

    Masahiro Yamazaki, Shinji Naganawa, Kiminori Bokura, Hisashi Kawai

    Nagoya J. Med. Sci. 76 No.3,4 285-291   Vol. 76 ( 3,4 ) page: 285-291   2014.8

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  305. Endolymphatic space size in patients with vestibular migraine and Ménière's disease.

    Nakada T, Yoshida T, Suga K, Kato M, Otake H, Kato K, Teranishi M, Sone M, Sugiura S, Kuno K, Pyykkö I, Naganawa S, Watanabe H, Sobue G, Nakashima T

    J Neurol.     2014.8

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    DOI: 10.1007/s00415-014-7458-9

  306. Evaluation of 11C-choline PET/CT for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract: a pilot study. Reviewed

    Naoto Sassa, Katsuhiko Kato, Shinji Abe, Shingo Iwano, Shinji Ito, Mitsuru Ikeda, Kazuhiro Shimamoto, Seiichi Yamamoto, Tokunori Yamamoto, Momokazu Gotoh, Shinji Naganawa

    Eur J Nucl Med Mol Imaging     2014.8

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    DOI: 10.1007/s00259-014-2871-y

  307. 腫瘍性病変との鑑別が困難であった小児骨髄炎の1例

    伊藤倫太郎、中根俊樹、長縄慎二、濱 麻人、筑紫 聡、下山芳江

    映像情報Medical   Vol. 46 ( 6 ) page: 518-519   2014.6

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  308. 内耳―3D-FLAIR法がもたらした新たな潮流

    長縄慎二

    INNERVISION 5月号     page: 49-51   2014.4

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  309. Visualization of white matter tracts using a non-diffusion weighted magnetic resonance imaging method: Does intravenous gadolinium injection four hours prior to the examination affect the visualization of white matter tracts?

    Masahiro Yamazaki, Shinji Naganawa, Hisashi Kawai, Mitsuru Ikeda, Kiminori Bokura, Haruo Isoda, Tsutomu Nakashima

    PLoS ONE   Vol. 9 ( 3 )   2014.3

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    DOI: 10.1371/journal.pone.0091860

  310. Retrospective Case Series of 15 Patients Treated with Chemoradiation Using 5-FU and Nedaplatin for Gynecological Malignancy: With Regard to Hemotoxicity.

    Yoshiyuki Itoh, Mitsuru Ikeda, Naoki Hirasawa, Shunichi Ishihara, Takahito Okuda, Takayuki Murao, Seiji Kubota, Tohru Okada, Shinji Naganawa, Takeo Ishigaki

    Nagoya Journal of Medical Science.   Vol. 76   page: 11-16   2014.2

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  311. FDG-PET/CTで陰性所見を示した肺腫瘤性病変の検討

    岩野信吾、長縄慎二、伊藤信嗣、加藤克彦

    臨床放射線   Vol. 59 ( 1 ) page: 154-164   2014.1

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  312. MRI and FDG-PET for Assessment of Response to Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer

    Toshisada Aiba, Keisuke Uehara, Takashi Nihashi, Toyonori Tsuzuki, Hiroshi Yatsuya, Yuichiro Yoshioka

    Ann Surg Oncol.   Vol. 21   page: 1801-1808   2014.1

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  313. A phase I study of concurrent chemoradiotherapy using oral s-1 for head and neck cancer.

    Yasushi fujimoto, Satoshi Kato, Yoshiyuki Itoh, Shinji Naganawa, Tsutomu Nakashima

    ANTICANCER RESEARCH   Vol. 34   page: 209-214   2014

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  314. Potential of a new MRI for visualizing cerebellar involvement in progressive supranuclear palsy.

    Kazuhiro Hara, Hirohisa Watanabe, Mizuki Ito, Takashi Tsuboi, Hazuki Watanabe, Ryoichi Nakamura, Jo Senda, Naoki Atsuta, Hiroaki Adachi, Ikuko Aiba, Shinji Naganawa, Gen Sobue

    Parkinsonism Relat Disord.   Vol. 20 ( 2 ) page: 157-161   2014

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  315. Clinical and radiological impact of liver transplantation for brain in cirrhosis patients without hepatic encephalopathy.

    Ishihara Tetsuro, Ito Mizuki, Niimi Yoshiki, Tsujimoto Masashi, Senda Jo, Kawai Yoshinari, Watanabe Hirohisa, Ishigami Masatoshi, Ito Takashi, Kamei Hideya, Onishi Yasuharu, Nakamura Taro, Goto Hidemi, Naganawa Shinji, Kiuchi Tetsuya, Sobue Gen.

    Clin Neurol Neurosurg. 2013 Nov;115(11):2341-7.   Vol. 115 ( 11 ) page: 2341-7   2013.11

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  316. 難聴を合併したMPO―ANCA 関連血管炎患者の3D―FLAIR MR 画像評価

    加藤 健、曾根三千彦、寺西正明、吉田忠雄、大竹宏直、中島 務、長縄慎二

    日本耳鼻咽喉科学会会誌   Vol. 116   page: 1192-1199   2013.11

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  317. Cortical and subcortical brain atrophy in Parkinson's disease with visual hallucination.

    Watanabe Hirohisa, Senda Jo, Kato Shigenori, Ito Mizuki, Atsuta Naoki, Hara Kazuhiro, Tsuboi Takashi, Katsuno Masahisa, Nakamura Tomohiko, Hirayama Masaaki, Adachi Hiroaki, Naganawa Shinji, Sobue Gen.

    Mov Disord.   Vol. 28 ( 12 ) page: 1732-6   2013.10

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  318. Endolymphatic hydrops revealed by magnetic resonance imaging in patients with acute low-tone sensorineural hearing loss.

    Shimono M, Teranishi M, Yoshida T, Kato M, Sano R, Otake H, Kato K, Sone M, Ohmiya N, Naganawa S, Nakashima T

    Otol Neurotol   Vol. 34 ( 7 ) page: 1241-6   2013.7

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  319. MRI進化への視点を示す 〈狭い、うるさい、長時間かかる〉果たしてMRIは優しくなれるか メーカーへの提言をふくめて

    長縄慎二

    新医療   Vol. 462 ( 6 ) page: 24-26   2013.6

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  320. Comparison of Liquid Crystal Display Monitors Calibrated With Gray-Scale Standard Display Function and With γ 2.2 and iPad: Observer Performance in Detection of Cerebral Infarction on Brain CT.

    Yoshimura K, Nihashi T, Ikeda M, Ando Y, Kawai H, Kawakami K, Kimura R, Okada Y, Okochi Y, Ota N, Tsuchiya K, Naganawa S.

    AJR Am J Roentgenol.   Vol. 200 ( 6 ) page: 1304-1309.   2013.6

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  321. Limited Efficacy of 18F-FDG PET/CT for Differentiation Between Metastasis-Free Pancreatic Cancer and Mass-Forming Pancreatitis.

    Kato K, Nihashi T, Ikeda M, Abe S, Iwano S, Itoh S, Shimamoto K, Naganawa S.

    Clin Nucl Med.   Vol. 38 ( 6 ) page: 417-21   2013.6

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  322. Three-dimensional Visualization of Endolymphatic Hydrops after Intravenous Administration of Single-dose Gadodiamide.

    Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T.

    Magn Reson Med Sci.     page: in press   2013.5

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  323. Magnetic resonance imaging of the inner ear after both intratympanic and intravenous gadolinium injections.

    Iida T, Teranishi M, Yoshida T, Otake H, Sone M, Kato M, Shimono M, Yamazaki M, Naganawa S, Nakashima T

    Acta Otolaryngol   Vol. 133 ( 5 ) page: 434-8   2013.5

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  324. Relationship of Myocardial Fibrosis to Left Ventricular and Mitochondrial Function in Nonischemic Dilated Cardiomyopathy-A Comparison of Focal and Interstitial Fibrosis.

    Yamada T, Hirashiki A, Cheng XW, Okumura T, Shimazu S, Okamoto R, Shinoda N, Isobe S, Takeshita K, Naganawa S, Kondo T, Murohara T

    J Card Fail   Vol. 19 ( 8 ) page: 557-64   2013.5

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  325. Visualization of Endolymphatic Hydrops in Ménière's Disease after Intravenous Administration of Single-dose Gadodiamide at 1.5T.

    Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T.

    Magn Reson Med Sci.     page: in press   2013.5

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  326. Comparison of the central adrenal vein and the common trunk of the left adrenal vein for adrenal venous sampling.

    Takada A, Suzuki K, Mori Y, Hyodo R, Kawakami K, Okochi Y, Naganawa S.

    J Vasc Interv Radiol.   Vol. 24 ( 4 ) page: 550-7   2013.4

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  327. 18F-FDG-PET/CT predicts survival in hypopharyngeal squamous cell carcinoma.

    Suzuki H, Kato K, Fujimoto Y, Itoh Y, Hiramatsu M, Maruo T, Naganawa S, Hasegawa Y, Nakashima T.

    Ann Nucl Med.   Vol. 27 ( 3 ) page: 297-302   2013.4

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  328. Comparison of the central adrenal vein and the common trunk of the left adrenal vein for adrenal venous sampling.

    Takada A, Suzuki K, Mori Y, Hyodo R, Kawakami K, Okochi Y, Naganawa S.

    J Vasc Interv Radiol.   Vol. 24 ( 4 ) page: 550-557   2013.4

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  329. Imaging of Ménière's disease after intravenous administration of single-dose gadodiamide: utility of multiplication of MR cisternography and HYDROPS image.

    NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu

    Magn Reson Med Sci   Vol. 12 ( 1 ) page: 63-68   2013.3

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  330. Pulmonary lobar volumetry using novel volumetric computer-aided diagnosis and computed tomography.

    Iwano S, Kitano M, Matsuo K, Kawakami K, Koike W, Kishimoto M, Inoue T, Li Y, Naganawa S.

    Interact Cardiovasc Thorac Surg.     page: in press   2013.3

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  331. Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere's disease.

    KATO Masahiro, SUGIURA Makoto, SHIMONO Mariko, YOSHIDA Tadao, OTAKE Hironao, KATO Ken, TERANISHI Masaaki, SONE Michihiko, YAMAZAKI Masahiro, NAGANAWA Shinji, NAKASHIMA Tsutomu

    Acta Otolaryngol   Vol. 133 ( 2 ) page: 123-129   2013.2

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  332. Planning of segmentectomy using three-dimensional computed tomography angiography with a virtual safety margin: Technique and initial experience.

    Iwano S, Yokoi K, Taniguchi T, Kawaguchi K, Fukui T, Naganawa S

    Lung Cance   Vol. 81 ( 3 ) page: 410-415   2013

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  333. Pulmonary lobar volumetry using novel volumetric computer-aided diagnosis and computed tomography.

    Iwano S, Kitano M, Matsuo K, Kawakami K, Koike W, Kishimoto M, Inoue T, Li Y, Naganawa S

    Interact Cardiovasc Thorac Surg     page: in press   2013

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  334. 乳癌―広がり診断―

    佐竹弘子、石垣聡子、長縄慎二

    画像診断 33(9)   Vol. 33 ( 9 ) page: 1044-1051   2013

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  335. (18)F-FDG-PET/CT predicts survival in hypopharyngeal squamous cell carcinoma.

    Hidenori Suzuki, Katsuhiko Kato, Yasushi Fujimoto, Yoshiyuki Itoh, Mariko Hiramatsu, Takashi Maruo, Shinji Naganawa, Yasuhisa Hasegawa, Tsutomu Nakashima

    Ann Nucl Med.   Vol. 27 ( 3 ) page: 297-302   2013

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  336. Clinical Evaluation of 12 Patients with Cervical Lymph Node Metastases from Squamous Cell Carcinoma of Unknown Primary: a Retrospective Review

    Nishiyama Kana, Itoh Yoshiyuki, Nakahara Rie, Asano Akiko, Okada Tohru, Kubota Seiji, Maki Sayo, Itoh Junji, Fujimoto Yasushi, Nakashima Tsutomu, Naganawa Shinji

    Austral-Asian Journal of Cancer   Vol. 12 ( 4 ) page: 275-283   2013

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  337. Doubling time calculations for lung cancer by three-dimensional computer-aided volumetry: Effects of inter-observer differences and nodule characteristics.

    Koike Wataru, Iwano Shingo, Matsuo Keiji, Kitano Mariko, Kawakami Kenichi, Naganawa Shinji

    J Med Imaging Radiat Oncol.     page: DOI   2013

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    DOI: DOI

  338. second look US―切除範囲決定の実際―

    佐竹弘子、石垣聡子、長縄慎二

    臨床画像   Vol. 29 ( 11 ) page: 1292-1300   2013

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  339. Evaluation of vascular activity in otosclerosis by laser Doppler flowmetry: comparison with computed tomographic densitometry.

    Sone Michihiko, Yoshida Tadao, Otake Hironao, Kato Ken, Teranishi Masaaki, Naganawa Shinji, Nakashima Tsutomu.

    Otol Neurotol.   Vol. 34 ( 9 ) page: 1559-63   2013

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  340. Cutting-edge MRI techniques for studying neurological diseases focusing on spinocerebellar degeneration.

      Vol. 53 ( 11 ) page: 1087-90   2013

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  341. Clinical use of 11C-methionine and 18F-FDG-PET for germinoma in central nervous system.

    Yoshiyuki Okochi, Takashi Nihashi, Masazumi Fuji, Katsuhiko Kato, Yumiko Okada, Yoshio Ando, Satoshi Maesawa, Shigenori Takebayashi, Toshihiko Wakabayashi, Shinji Naganawa

    Ann Nucl Med.   Vol. 24   page: DOI   2013

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  342. 神経疾患におけるMR撮像法の最先端:脊髄小脳変性症を中心に

    渡辺 宏久、千田 譲、伊藤 瑞規、熱田 直樹、原 一洋、渡辺 はづき、中村 亮一、坪井 崇、吉田 眞理、長縄 慎二、祖父江 元

    臨床神経学 2013;53(11):1087-90   Vol. 53 ( 11 ) page: 1087-90   2013

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  343. Establishing Normal Diameter Range of the Cochlear and Facial Nerves with 3D-CISS at 3T.

    Rei Nakamichi, Masahiro Yamazaki, Mitsuru Ikeda, Haruo Isoda, Hisashi Kawai, Michihiko Sone, Tsutomu Nakashima, Shinji Naganawa

    Magn Reson Med Sci.   Vol. 12 ( 4 ) page: 241-247   2013

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  344. Semi-quantification of Endolymphatic Size on MR Imaging after Intravenous Injection of Single-dose Gadodiamide: Comparison between Two Types of Processing Strategies.

    Shinji Naganawa, Kojiro Suzuki, Rei Nakamichi, Kiminori Bokura, Tadao Yoshida, Michihiko Sone, Homann Georg, Tsutomu Nakashima, Mitsuru Ikeda

    Magn Reson Med Sci.   Vol. 12 ( 4 ) page: 261-269   2013

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  345. Imaging of Ménière's disease by subtraction of MR cisternography from positive perilymph image.

    NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu

    Magn Reson Med Sci   Vol. 11 ( 4 ) page: 303-309   2012.12

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  346. Gadolinium distribution in cochlear perilymph: differences between intratympanic and intravenous gadolinium injection.

    Yamazaki M, Naganawa S, Kawai H, Sone M, Nakashima T

    Neuroradiology   Vol. 54 ( 10 ) page: 1161-9   2012.10

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  347. Differentiation of newly diagnosed glioblastoma multiforme and intracranial diffuse large B-cell Lymphoma using 11C-methionine and 18F-FDG PET.

    Okada Y, Nihashi T, Fujii M, Kato K, Okochi Y, Ando Y, Yamashita M, Maesawa S, Takebayashi S, Wakabayashi T, Naganawa S

    Clin Nucl Med   Vol. 37 ( 9 ) page: 843-9   2012.9

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  348. Imaging of Ménière's disease after intravenous administration of single-dose gadodiamide: utility of subtraction images with different inversion time.

    NAGANAWA Shinji, YAMAZAKI Masahiro, KAWAI Hisashi, BOKURA Kiminori, SONE Michihiko, NAKASHIMA Tsutomu

    Magn Reson Med Sci   Vol. 11 ( 3 ) page: 213-219   2012.9

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  349. 臨床の立場から見たISMRM2012のトピックス

    長縄慎二

    INNERVISION   Vol. 27 ( 9 ) page: 71-72   2012.9

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  350. Peak width in multifrequency tympanometry and endolymphatic hydrops revealed by magnetic resonance imaging.

    Kato K, Yoshida T, Teranishi M, Sano R, Otake H, Sone M, Naganawa S, Nakashima T

    Otol Neurotol   Vol. 33 ( 6 ) page: 912-5   2012.8

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  351. Gadolinium distribution in cochlear perilymph: differences between intratympanic and intravenous gadolinium injection.

    YAMAZAKI Masahiro, NAGANAWA Shinji, KAWAI Hisashi, SONE Michihiko, NAKASHIMA Tsutomu

    Neuroradiology   Vol. 54 ( 10 ) page: 1161-1169   2012.8

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  352. MRI mean diffusivity detects widespread brain degeneration in multiple sclerosis

    SENDA JOE ,WATANABE HIROHISA,TSUBOI TAKASHI ,HARA KAZUHIRO,WATANABE HAZUKI ,NAKAMURA RYOICHI,ITO MIZUKI,ATSUTA NAOKI,TANAKA FUMIAKI,NAGANAWA SHINJI,SOBUE GEN

    Journal of the Neurological Sciences   Vol. 319 ( 1-2 ) page: 105-10   2012.8

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  353. Correlation between dynamic CT findings and pathological prognostic factors of small lung adenocarcinoma.

    IWANO SHINGO, KOIKE WATARU, MATSUO KEIJI, KITANO MARIKO, KAWAKAMI KENICHI, OKADA TOHRU, NAGANAWA SHINJI

    Cancer Imaging.   Vol. 29 ( 12 ) page: 187-93   2012.6

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  354. MRIを施設のアイコンにするための要件と課題を説く

    長縄慎二

    新医療   ( 6 ) page: 28-30   2012.6

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  355. Virtual Bronchoscopic Navigation(VBN)による気管支鏡下生検経路の診断精度

    岸本真理子、岩野信吾、長縄慎二

    映像情報メディカル   Vol. 44 ( 6 ) page: 602-603   2012.6

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  356. Contrast enhancement of the inner ear in magnetic resonance images taken at 10 minutes or 4 hours after intravenous gadolinium injection.

    Sano R, Teranishi M, Yamazaki M, Isoda H, Naganawa S, Sone M, Hiramatsu M, Yoshida T, Suzuki H, Nakashima T

    Acta Otolaryngol   Vol. 132 ( 3 ) page: 241-246   2012.5

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  357. 急性感音難聴の新しい画像診断

    長縄慎二

    JOHNS   Vol. 28 ( 5 ) page: 747-750   2012.5

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  358. Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection.

    YAMAZAKI MASAHIRO, NAGANAWA SHINJI, TAGAYA MITSUHIKO, KAWAI HISASHI, IKEDA MITSURU, SONE MICHIHIKO, TERANISHI MASAAKI, SUZUKI HIROKAZU, NAKASHIMA TSUTOMU

    AJNR Am J Neuroradiol   Vol. 33 ( 4 ) page: 773–78   2012.4

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  359. CT findings of intraductal papillary neoplasm of the bile duct: Assessment with multiphase contrast-enhanced examination using multi-detector CT.

    OGAWA HIROSHI,ITOH SHIGEKI,NAGASAKA TETSURO,SUZUKI KOJIRO,OTA TOYOHIRO,NAGANAWA SHINJI

    Clin Radiol   Vol. 67 ( 3 ) page: 224-231   2012.3

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  360. Audiological signs in pediatric cases with dehiscence of the bony labyrinth caused by a high jugular bulb.

    Michihiko Sone, Naomi Katayama, Shinji Naganawa, Tadao Yoshida, Masaaki Teranishi,Tsutomu Nakashima

    Int J Pediatr Otorhinolaryngol   Vol. 76 ( 3 ) page: 447-451   2012.3

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  361. 十二指腸乳頭部癌の画像診断-マルチスライスCTを中心に-

    高田章、鈴木耕次郎、石垣聡子、伊藤茂樹、長縄慎二

    胆と膵   Vol. 33 ( 3 ) page: 243-248   2012.3

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  362. Estimation of I-123 IMP arterial blood activity using I-123 IMP acquisition data from the lungs and brain without any blood sampling: Validation of its usefulness for quantification of regional cerebral blood flow.

    ABE SHINJI, KATO KATSUHIKO, TAKAHASHI YOSHITAKE, FUJITA NAOTOSHI, YAMASHITA MASATO, SHINODA MASAKI, IKEDA MITSURU, OTA NAOTOSHI, KAJITA YASUKAZU, NAGANAWA SHINJI

    Clin Nucl Med   Vol. 37 ( 3 ) page: 258-263   2012.3

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  363. Diffusion-weighted imaging of breast masses: comparison of diagnostic performance using various apparent diffusion coefficient parameters.

    HIRANO MAKI,SATAKE HIROKO,ISHIGAKI SATOKO,IKEDA MITSURU,KAWAI HISASHI,NAGANAWA SHINJI

    AJR Am J Roentgenol   Vol. 198 ( 3 ) page: 717-22   2012.3

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  364. Imaging of Ménière's Disease after Intravenous Administration of Single-dose Gadodiamide: Utility of Subtraction Images with Different Inversion Time.

    Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T.

    Magn Reson Med Sci   Vol. 11 ( 3 ) page: 213-9   2012.3

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  365. Imaging of endolymphatic and perilymphatic fluid after intravenous administration of single-dose gadodiamide.

    Naganawa S, Yamazaki M, Kawai H, Bokura K, Sone M, Nakashima T

    Magn Reson Med Sci   Vol. 11 ( 2 ) page: 145-50   2012.2

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  366. 脳機能MR画像解析-3T MR装置における施設内及び施設間の再現性の検証-

    長縄慎二

    映像情報メディカル   Vol. 44 ( 1 ) page: 104-105   2012.1

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  367. 画像検査

    長縄慎二、中島 務

      Vol. 30 ( 1 ) page: 61-63   2012.1

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  368. Study of the Cost-Benefit Analysis of Electronic Medical Record Systems in General Hospital in China.

    Li K, Naganawa S, Wang K, Li P, Kato K, Li X, Zhang J, Yamauchi K.

    J Med Syst     page: 10.1007   2012

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  369. Comparison of computed tomography and magnetic resonance imaging for evaluation of cholesteatoma with labyrinthine fistulae.

    Michihiko Sone, Tadao Yoshida, Shinji Naganawa, Hironao Otake, Ken Kato, Rui Sano, Masaaki Teranishi,Tsutomu Nakashima

        page: 10.1002   2012

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  370. Estimation of perilymph enhancement after intrarympanic administration of Gd-DTPA by fast T1-mapping with dual flip angle 3D-spoiled gradient echo sequence Reviewed

    NAGANAWA SHINJI, MASAHIRO YAMAZAKI, KAWAI HISASHI, NAKASHIMA TSUTOMU

    Proc.Intl.Mag.Reson.Med     page: .   2012

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  371. MRI mean diffusivity detects widespread brain degeneration in multiple sclerosis

    SENDA JOE ,WATANABE HIROHISA,TSUBOI TAKASHI ,HARA KAZUHIRO,WATANABE HAZUKI ,NAKAMURA RYOICHI,ITO MIZUKI,ATSUTA NAOKI,TANAKA FUMIAKI,NAGANAWA SHINJI,SOBUE GEN

    Journal of the Neurological Sciences     page: .   2012

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  372. Autoimmune pancreatitis: Assessment of the enhanced duct sign on multiphase contrast-enhanced computed tomography

    KAWAI YUICHI,SUZUKI KOJIRO,ITOH SHIGEKI,TAKADA AKIRA,MORI YOSHINE,NAGANAWA SHINJI

    European Journal of Radiology     page: .   2012

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  373. The diagnosis of neurodegenerative disorders based on clinical and pathological findings using an MRI approach.

    Rinsho Shinkeigaku   Vol. 51 ( 11 ) page: 863-864   2011.11

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  374. Contrast Enhancement of the Anterior Eye Segment and Subarachnoid Space: Detection in the Normal State by Heavily T(2)-weighted 3D FLAIR.

    NAGANAWA SHINJI,YAMAZAKI MASAHIRO,KAWAI HISASHI,SONE MICHIHIKO,NAKASHIMA TSUTOMU

    Magn Reson Med Sci   Vol. 10 ( 3 ) page: 193-199   2011.10

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  375. Anatomical Details of the Brainstem and Cranial Nerves Visualized by High Resolution Readout-segmented Multi-shot Echo-planar Diffusion-weighted Images using Unidirectional MPG at 3T.

    Naganawa S, Yamazaki M, Kawai H, Sone M, Nakashima T, Isoda H

    Magn Reson Med Sci   Vol. 10 ( 4 ) page: 269-275   2011.10

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  376. Foreign body granulomaと病理診断された腫瘤形成性膵炎の1例

    河合雄一、鈴木耕次郎、小川浩、太田豊裕、長縄慎二、伊藤茂樹、藤井努

    臨床放射線   Vol. 56 ( 10 ) page: 1250-1253   2011.10

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  377. 側頭骨 (内耳、内耳道)

    長縄慎二

    画像診断 臨時増刊号   Vol. 31 ( 11 ) page: S108-S118   2011.9

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  378. 乳腺造影3T MRIの診断法と臨床的意義

    佐竹弘子、石垣聡子、木村麗子、川井 恒、長縄慎二

    INNERVISON   Vol. 26 ( 9 ) page: 82-86   2011.9

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  379. 臨床の立場から見たISMRM2011のトピックス-イメージングバイオマーカーとしての進歩・定量化を中心に

    長縄慎二

    INNERVISION   Vol. 26 ( 9 ) page: 57-59   2011.9

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  380. Scattered radiation from dental metallic crowns in head and neck radiotherapy.

    Shimozato T, Igarashi Y, Itoh Y, Yamamoto N, Okudaira K, Tabushi K, Obata Y, Komori M, Naganawa S, Ueda M.

    Phys Med Biol.   Vol. 56 ( 17 ) page: 5525-5534   2011.8

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  381. Images of a Case of Carney Triad by Combined F-18 FDG PET/CT.

    KATO KATSUHIKO, KOIKE WATARU, IWANO SHINGO, USAMI NORIHIRO, YOKOI KOHEI, UEDA YUICHI, NAGANAWA SHINJI

    Clin Nucl Med   Vol. 36 ( 8 ) page: 698-700   2011.8

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  382. CTを利用した子宮頸癌腔内照射の治療システムの構築 画像誘導小線源治療に向けて

    平澤直樹、伊藤善之、久保田誠司、青山裕一、野口由美子、奥平訓康、中原理絵、牧 紗代、石原俊一、三宅良和、長縄慎二

    臨床放射線   Vol. 56 ( 7 ) page: 873-877   2011.7

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  383. 普及型と研究型に棲み分けされるMRIの今後を示す

    長縄慎二

    新医療   Vol. 438 ( 6 ) page: 24-27   2011.6

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  384. Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging

    TSUJIMOTO MASASHI,SENDA JO , ISHIHARA TETSURO, NIIMI YOSHIKI, KAWAI YOSHINARI, ATSUTA NAOKI,WATANABE HIROHISA, TANAKA FUMIAKI, NAGANAWA SHINJI, SOBUE GEN

    J Neurol Sci.   Vol. 307 ( 1-2 ) page: 34-40   2011.6

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  385. 乳癌に対する乳房部分切除後の放射線治療 術中照射を中心に

    石原俊一、伊藤善之、中原理絵、牧 紗代、久保田誠司、平澤直樹、長縄慎二、今井常夫、菊森豊根、澤木正孝、青山裕一、三宅良和

    臨床放射線   Vol. 56 ( 4 ) page: 501-510   2011.4

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  386. Accuracy of 3.0 Tesla magnetic resonance imaging in the diagnosis of intracochlear schwannoma.

    YOSHIDA TADAO ,SONE MICHIHIKO,NAGANAWA SHINJI,NAKASHIMA TSUTOMU

    Auris Nasus Larynx   Vol. 38 ( 4 ) page: 551-554   2011.4

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  387. A comparative contrast perception phantom image of brain CT study between high-grade and low-grade liquid crystal displays (LCDs) in electronic medical charts

    YOSHIMURA KUMIKO, SHIMAMOTO KAZUHIRO , IKEDA MITSURU , ICHIKAWA KATSUHIRO , NAGANAWA SHINJIPhysica Medica

    Physica Medica   ( 27 ) page: 109-116   2011.4

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  388. Contrast-enhanced MRI of the inner ear after intratympanic injection of meglumine gadopentetate or gadodiamide hydrate.

    SUZUKI HIROKAZU,TERANISHI MASAAKI,NAGANAWA SHINJI,NAKATA SEIICHI,SONE MICHIHIKO,NAKASHIMA TSUTOMU

    Acta Otolaryngol   Vol. 131 ( 2 ) page: 130-135   2011.2

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  389. Visualization of Endolymphatic Hydrops after Intratympanic Injection of Gd-DTPA: Comparison of 2D and 3D Real Inversion Recovery Imaging.

    NAGANAWA SHINJI,SONE MICHIHIKO ,YAMAZAKI MASAHIRO,KAWAI HISASHI,NAKASHIMA TSUTOMU

    Magn Reson Med Sci.   Vol. 10 ( 2 ) page: 101-106   2011.2

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  390. Endolympathic hydrops in patients with vestibular schwannoma: visualization by non-contrast-enhanced 3D FLAIR.

    Naganawa S, Kawai H, Sone M, Nakashima T, Ikeda M

    Neuroradiology     2011.1

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    DOI: in press

  391. Predictive value for malignancy of suspicious breast masses of BI-RADS categories 4 and 5 using ultrasound elastography and MR diffusion-weighted imaging.

    SATAKE HIROKO,NISHIO AKIKO,IKEDA MITSURU, ISHIGAKI SATOKO, SHIMAMOTO KAZUHIRO, HIRANO MAKI, NAGANAWA SHINJI

    AJR Am J Roentgenol   Vol. 196 ( 1 ) page: 202-209   2011.1

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  392. Progressive and widespread brain damage in ALS: MRI voxel-based morphometry and diffusion tensor imaging study.

    Senda J, Kato S, Kaga T, Ito M, Atsuta N, Nakamura T, Watanabe H, Tanaka F, Naganawa S, Sobue G

    Amyotroph Lateral Scler   Vol. 12 ( 1 ) page: 59-56   2011.1

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  393. Contrast enhancement of the inner ear after intravenous administration of a standard or double dose of gadolinium contrast agents.

    SUZUKI HIROKAZU, TERANISHI MASAAKI, SONE MICHIHIKO, YAMAZAKI MASAHIRO, NAGANAWA SHINJI, NAKASHIMATSUTOMU

    Acta Oto-Laryngologica   Vol. 131   page: 1025-1031   2011

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  394. EARLY PREDICTION OF RESPONSE TO NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED BREAST CANCER USING MRI.

    KAWAMURA MARIKO, SATAKE HIROKO, ISHIGAKI SATOKO, NISHIO AKIKO, SAWAKI MASATAKA , NAGANAWA SHINJI

    Nagoya J Med Sci   Vol. 73 ( 3-4 ) page: 147-156   2011

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  395. 特発性と考えられた陳旧性肝内血腫の1例

    鈴木耕次郎、森芳峰、長縄慎二、太田豊裕、伊藤茂樹、野本周嗣

    臨床放射線   Vol. 56   page: 1098-1102   2011

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  396. Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection.

    YAMAZAKI MASAHIRO, NAGANAWA SHINJI, TAGAYA MITSUHIKO, KAWAI HISASHI, IKEDA MITSURU, SONE MICHIHIKO, TERANISHI MASAAKI, SUZUKI HIROKAZU, NAKASHIMA TSUTOMU

    AJNR Am J Neuroradiol     page: .   2011

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  397. Segmentectomy Simulation using a Virtual Three-dimensional Safety Margin.

    IWANO SHINGO, USAMI NORIYASU, YOKOI KOHEI, NAGANAWA SHINJI

    Ann Thorac Surg     page: in press   2011

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  398. 3D-CT Lung Volumetry Using Multidetector Row Computed Tomography: Pulmonary Function of Each Anatomic Lobe.

    IWANO SHINGO, OKADA TOHRU, SATAKE HIROKO, NAGANAWA SHINJI

    J Thorac Imaging     page: .   2011

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  399. FDG-PET performed concurrently with initial I-131 ablation for differentiated thyroid cancer.

    Iwano Shingo, Kato Katsuhiko, Ito Shinji, Tsuchiya Kenichi, Naganawa Shinji

    Ann Nucl Med     page: in press   2011

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  400. Association Between Endolymphatic Hydrops as Revealed by Magnetic Resonance Imaging and Caloric Response.

    KATO MASAHIRO, TERANISHI MASAAKI, KATAYAMA NAOMI, SONE MICHIHIKO, NAGANAWA SHINJI, NAKASHIMA TSUTOMU

    Otology & Neurotology   Vol. 32 ( 9 ) page: 1480-1485   2011

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  401. 3D-CT Lung Volumetry Using Multidetector Row Computed Tomography:Pulmonary Function of Each Anatomic Lobe.

    IWANO SHINGO, OKADA TOHRU, SATAKE HIROKO, NAGANAWA SHINJI

    J Thorac Imaging     page: in press   2011

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  402. ここまでわかる耳鼻咽喉科MRI「内耳のMRI」

    中島務、長縄慎二

    MB ENT   Vol. 122   page: 20-26   2010.12

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  403. Magnetic resonance imaging of the inner ear in Meniere's disease.

    Ilmari Pyykk&ouml;; Jing Zou; Dennis Poe; Tsutomu Nakashima; Shinji Naganawa

    Otolaryngologic clinics of North America   Vol. 43 ( 5 ) page: 1059-1080   2010.10

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  404. パーキンソニズムを呈する疾患のMRI診断

    渡辺宏久、吉田眞理、饗場郁子、長縄慎二、祖父江元

    自律神経   Vol. 47 ( 5 ) page: 402-411   2010.10

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  405. 臨床の立場からみたISMRMへのトピックスー7Tを中心とした国際的な動向について

    長縄慎二

      Vol. 25 ( 9 ) page: 62-62   2010.9

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  406. Increased sensitivity to low concentration gadolinium contrast by optimized heavily T2-weighted 3D-FLAIR to visualize endolymphatic space.

    NAGANAWA SHINJI, KAWAI HISASHI, SONE MICHIHIKO,NAKASHIMA TSUTOMU

    Magn Reson Med Sci   Vol. 9   page: 73-80   2010.9

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  407. Simultaneous three-dimensional visualization of the intra-parotid facial nerve and parotid duct using a three-dimensional reversed FISP sequence with diffusion weighting.

    NAGANAWA SHINJI, ISHIHARA SHUNICHI, SATAKE HIROKO, KAWAI HISASHI, SONE MICHIHIKO, NAKASHIMA TSUTOMU

    Magn Reson Med Sci   Vol. 9   page: 153-158   2010.9

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  408. CT findings in autoimmune pancreatitis: assessment using multiphase contrast-enhanced multisection CT.

    SUZUKI KOJIRO, ITOH SHIGEKI, NAGASAKA T, OGAWA HIROSHI, OTA TOYOHIRO, NAGANAWA SHINJI

    Clin Radiol   Vol. 65   page: 735-743   2010.9

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  409. Diagnostic value of SPIO-mediated breath-hold, black-blood, fluid-attenuated, inversion recovery (BH-BB-FLAIR) imaging in patients with hepatocellular carcinomas.

    MATSUSHIMA MASAYA, NAGANAWA SHINJI, IKEDA MITSURU, ITOH SHIGEKI, OGAWA HIROSHI, KOMADA TOMOHIRO, ISHIGAKI SATOKO, KAWAI HISASHI, SUZUKI KOJIRO, SATAKE HIROKO, IWANO SHINGO

    Magn Reason Med Sci   Vol. 9 ( 2 ) page: 49-58   2010.9

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  410. Evaluation of 11C-choline PET/CT for primary diagnosis and staging of urothelial carcinoma of the upper urinary tract: a pilot study.

    Naoto Sassa, Katsuhiko Kato, Shinji Abe, Shingo Iwano, Shinji Ito, Mitsuru Ikeda, Kazuhiro Shimamoto, Seiichi Yamamoto, Tokunori Yamamoto, Momokazu Gotoh, Shinji Naganawa

    Eur J Nucl Med Mol Imaging     2010.8

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    DOI: 10.1007/s00259-014-2871-y

  411. 臨床に及ぼす画像診断機器の有用性と今後の展望

    医療機器システム白書   Vol. 2010~2011   page: 16-20   2010.7

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  412. Imaging findings in a case with cholesteatoma in complete aural atresia.

    Sone M, Naganawa S, Yoshida T, Nakata S, Nakashima T

    Am J Otolaryngol   Vol. 31 ( 4 ) page: 297-299   2010.7

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  413. 側頭骨領域の造影3T MRI

    長縄慎二

    INNERVISION   Vol. 25 ( 7 ) page: 6-10   2010.7

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  414. なぜ先進的病院が高磁場MRIを導入・稼動しなければならないのか

    長縄慎二

    新医療   Vol. 6   page: 28-31   2010.6

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  415. Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis.

    HIRASAWA NAOKI, ITOH YOSHIYUKI ISHIHARA SHUNICHI, KUBOTA SEIJI, ITOH JUNJI, FUJIMOTO YASUSHI, NAKASHIMA TSUTOMU, NAGANAWA SHINJI

    Head Neck Oncol   Vol. 2 ( 20 )   2010.6

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  416. 早期声門癌に対する治療方針に関するアンケート調査 耳鼻科医を対象とした調査結果

    平澤直樹、伊藤善之、石原俊一、長縄慎二、鈴木一徳、野本由人、村尾豪之、堀川よしみ、小山一之、笹岡政宏、浅野晶子、小幡康範

    臨床放射線   Vol. 55   page: 541-546   2010.5

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  417. White matter microstructure of the cingulum and cerebellar peduncle is related to sustained attention and working memory: A diffusion tensor imaging study.

    Takahashi M, Iwamoto K, Fukatsu H, Naganawa S, Iidaka T, Ozaki N

    Neurosci Lett   Vol. 477 ( 2 ) page: 72-76   2010.4

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  418. 第3回論文発表における学術研究成果報告のノウハウ

    長縄慎二

    映像情報Medical   Vol. 42 ( 3 ) page: 316-317   2010.3

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  419. Three-dimensional (3D) visualization of endolymphatic hydrops after intratympanic injection of Gd-DTPA: optimization of a 3D-real inversion-recovery turbo spin-echo (TSE) sequence and application of a 32-channel head coil at 3T.

    Shinji Naganawa, Shunichi Ishihara,Shingo Iwano,Michihiko Sone, Tsutomu Nakashima

    JOURNAL OF MAGNETIC RESONANCE IMAGING   Vol. 31   page: 210-241   2010.1

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  420. Relationship between endolymphatic hydrops and vestibular-evoked myogenic potential.

    Katayama Naomi, Yamamoto Masako, Teranishi Masaaki, Naganawa Shinji, Nakata Seiichi, Sone Michihiko, Nakashima Tsutomu

    Acta Otolaryngol   Vol. 130 ( 8 ) page: 917-923   2010.1

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  421. Detection of presumed hemorrhage in the ampullar endolymph of the semicircular canal: a case report.

    Naganawa, Shinji; Ishihara, Shunichi; Iwano, Shingo; Sone, Michihiko; Nakashima, Tsutomu

    Magn Reson Med Sci   Vol. 8   page: 187-191   2010

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    We examined a 61-year-old woman with sudden left-side hearing loss accompanied by severe vertigo. High signal in the ampullar endolymph of the left semicircular canal on magnetic resonance (MR) fluid attenuated inversion recovery (3D-FLAIR) images suggested labyrinthine hemorrhage. The patient had been treated for chronic heart failure and prescribed 100 mg/day of acetylsalicylic acid (aspirin) for its antiplatelet effect. The 3D-FLAIR images demonstrated a small amount of focal hemorrhage in the labyrinthine fluid that may have been overlooked on T(1)-weighted images.

  422. MR imaging of the Cochlear Modiolus after Intratympanic Administration of Gd-DTPA

    Hisashi Kawai, Shinji Naganawa, Shunichi Ishihara, Michihiko Sone, Tsutomu Nakashima

    Magn Reson Med Sci   Vol. 9 ( 1 ) page: 23-29   2010

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  423. Estimation of Gadolinium-induced T(1)-shortening with Measurement of Simple Signal Intensity Ratio between the Cochlea and Brain Parenchyma on 3D-FLAIR: Correlation with T(1) Measurement by TI Scout Sequence.

    Shinji Naganawa, Shunichi Ishihara,Shingo Iwano,Hisashi Kawai, Michihiko Sone, Tsutomu Nakashima

    Magn Reson Med Sci   Vol. 9 ( 1 ) page: 17-22   2010

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  424. 3 Tesla magnetic resonance imaging obtained 4 hours after intravenous gadolinium injection in patients with sudden deafness.

    Tagaya, Mitsuhiko; Teranishi, Masaaki; Naganawa, Shinji; Iwata, Tomoyuki; Yoshida, Tadao; Otake, Hironao; Nakata, Seiichi; Sone, Michihiko; Nakashima, Tsutomu

    Acta Otolaryngol   Vol. 130   page: 665-669   2010

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  425. Signal Alteration of the Cochlear Perilymph on 3 Different Sequences after Intratympanic Gd-DTPA Administration at 3 Tesla:Comparison of 3D-FLAIR,3D-T1-weighted Imaging,and 3D-CISS.

    Yamazaki Masahiro,Naganawa Shinji,Kawai Hisashi,Nihashi Takashi,Nakashima Tsutomu

    Magn Reason Med Sci   Vol. 9 ( 2 ) page: 65-71   2010

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  426. Correlation between estimated glomerular filtration rate (eGFR) and apparent diffusion coefficient (ADC) values of the kidneys.

    Toya Reiko,Naganawa Shinji,Kawai Hisashi,Ikeda Mitsuru

    Magn Reson Med Sci   Vol. 9   page: 59-64   2010

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  427. A comparative contrast perception phantom image of brain CT study between high-grade and low-grade liquid crystal displays (LCDs) in electronic medical charts.

    Yoshimura Kumiko, Shimamoto Kazuhiro, Ikeda Mitsuru, Ichikawa Katsuhiro, Naganawa Shinji

    Phys Med.   Vol. in press   2010

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  428. Putaminal magnetic resonance imaging features at various magnetic field strengths in multiple system atrophy.

    Watanabe H, Ito M, Fukatsu H, Senda J, Atsuta N, Kaga T, Kato S, Katsuno M, Tanaka F, Hirayama M, Naganawa S, Sobue G

    Mov Disord   Vol. in press   2010

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  429. Impact of adjustment measures on reducing outpatient waiting time in a community hospital: application of a computer simulation.

    Chen, Bai-lian; Li, En-dong; Yamawuchi, Kazunobu; Kato, Ken; Naganawa, Shinji; Miao, Wei-jun

    Chin Med J (Engl)   Vol. 123 ( 5 ) page: 574-580   2010

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  430. Relationship between the Degree of Endolymphatic Hydrops and Electrocochleography.

    Yamamoto M, Teranishi M, Naganawa S, Otake H, Sugiura M, Yamamoto Masako, Teranishi Masaaki, Naganawa Shinji, Otake Hironao, Sugiura Makoto, Iwata Tomoyuki, Yoshida Tadao, Katayama Naomi, Nakata Seiichi, Sone Michihiko, Nakashima Tsutomu

    Audiol Neurootol   Vol. 15   page: 254-260   2010

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  431. Virtual bronchoscopy-guided transbronchial biopsy for aiding the diagnosis of peripheral lung cancer.

    Iwano Shingo, Imaizumi Kazuyozhi, Okada Tohru, Hasegawa Yoshinori, Naganawa Shinji

    Eur J Radiol   Vol. in press   2010

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    The aim of this study was to evaluate the clinical value of virtual bronchoscopy (VB) in aiding diagnosis of peripheral lung cancer by transbronchial biopsy (TBB). In addition, we sought to systematically analyze the factors that affect the diagnostic sensitivity of VB-guided TBB for the evaluation of peripheral lung cancers. MATERIALS AND METHODS: A hundred and twenty-two peripheral lung cancers from 122 patients (82 men and 40 women, 38-84 years; median 68.5 years) who were performed VB-guided TBB were evaluated retrospectively. VB was reconstructed from 1- or 0.5-mm slice thickness images of multi-detector CT (MDCT). Experienced pulmonologists inserted the conventional and ultrathin bronchoscopes into the target bronchus under direct vision following the VB image. RESULTS: A definitive diagnosis was established by VB-guided TBB in 96 lesions (79%). The diagnostic sensitivity of small pulmonary lesions </=30mm in maximal diameter (71%) was significantly lower than that of lesions >30mm (91%, p=0.008). For small pulmonary lesions </=30mm (n=76), internal opacity of the lesion was the independent predictor of diagnostic sensitivity by VB-guided TBB, and the non-solid type lung cancers were significantly lower than the solid type and part-solid type lung cancers for diagnostic sensitivity (odds ratio=0.161; 95% confidence interval=0.033-0.780; p=0.023). CONCLUSION: Use of an ultrathin bronchoscope and simulation with VB reconstructed by high quality MDCT images is thought to improve pathological diagnosis of peripheral lung cancers, especially for solid and partly solid types. For small pulmonary lesions </=30mm, the lesion internal opacity is a significant factor for predicting the diagnostic sensitivity, and the sensitivity was low for small non-solid type of lung cancers.

  432. Correlation between pyramidal tract degeneration and widespread white matter involvement in amyotrophic lateral sclerosis: a study with tractography and diffusion-tensor imaging.

    Senda, Joe; Ito, Mizuki; Watanabe, Hirohisa; Atsuta, Naoki; Kawai, Yoshinari; Katsuno, Masahisa; Tanaka, Fumiaki; Naganawa, Shinji; Fukatsu, Hiroshi; Sobue, Gen

    Amyotroph Lateral Scler   Vol. 10   page: 288-294   2009.12

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    Our aim was to evaluate the location and extent of white matter involvement in patients with amyotrophic lateral sclerosis (ALS) using diffusion-tensor magnetic resonance imaging (DTI). We obtained fractional anisotropy (FA) values from the internal capsule and various white matter regions of 46 patients with sporadic ALS and 19 control subjects. In ALS patients, FA values in the internal capsule, frontal white matter, genu and splenium of the corpus callosum (p<0.001), parietal and temporal lobe white matter, and posterior cingulum (p<0.05) were significantly lower than in controls. FA values in frontal white matter were lower than in parietal white matter (p<0.001). Decreased FA values in frontal, parietal, and temporal white matter, and the genu of the corpus callosum, correlated significantly with those in the internal capsule (r=0.66 and p<0.001, r=0.47 and p=0.001, r=0.33 and p=0.021, r=0.41 and p=0.005, respectively). No such correlations were found for FA values in other white matter areas or in controls. Patient FA values generally were not correlated with disease duration. DTI demonstrated more widespread involvement of the cerebral white matter in ALS patients than previously believed. The severity of involvement in the frontal, temporal and parietal white matter correlated with severity in the pyramidal tract.

  433. Endolymphatic space imaging in patients with delayed endolymphatic hydrops.

    Kasai Sachio; Teranishi Masaaki; Katayama Naomi; Sugiura Makoto; Nakata Seiichi; Sone Michihiko; Naganawa Shinji; Nakashima Tsutomu

    Acta Otolaryngol   Vol. 129   page: 1163-1174   2009.11

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  434. 鼓室内ガドリニウム造影剤注入による内耳内リンパ水腫の可視化

    長縄慎二

    映像情報 medical   Vol. 41 ( 10 ) page: 967-1006   2009.9

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  435. Comparisons of I-123 diagnostic and I-131 post-treatment scans for detecting residual thyroid tissue and metastases of differentiated thyroid cancer.

    IWANO SHINGO,KATO KATSUHIKO, NIHASHI TAKASHI,ITO SHIGEKI, TACHI YASUSHI, NAGANAWA SHINJI

    Ann Nucl Med   Vol. 2009 ( sep ) page: 25   2009.9

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  436. Lymphoplasmacytic sclerosing cholangitis: assessment of clinical, CT, and pathological findings.

    Itoh Shigeki; Nagasaka T; Suzuki Koujiro; Satake Hiroko; Ota Toyohiro; Naganawa Shinji

    Clin Radiol   ( 64 ) page: 1104-1114   2009.9

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  437. Individual Differences in the Permeability of the Round Window: Evaluating the Movement of Intratympanic Gadolinium Into the Inner Ear.

    Yoshioka M, Naganawa S, Sone M, Nakata S, Teranishi M, Nakashima T

    Otol Neurotol   Vol. 30 ( 5 ) page: 645-648   2009.8

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  438. MRIは画像診断の中心になっていくべき象徴的存在である

    長縄慎二

    月刊 新医療   Vol. 416 ( 8 ) page: 84-87   2009.8

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  439. 3T MR

    長縄慎二

      Vol. 2009 ( 11 ) page: 151-160   2009.8

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  440. Increased signal intensity of the cochlea on pre- and post-contrast enhanced 3D-FLAIR in patients with vestibular schwannoma.

    Yamazaki M, Naganawa S, Kawai H, Nihashi T, Fukatsu H, Nakashima T

    Neuroradiology   Vol. in press   2009.8

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  441. Stenosis of the third portion of the duodenum due to bleeding from the anterior pancreaticoduodenal artery: assessment by multiphase contrast-enhanced examination with multislice CT.

    Itoh Shigeki, Mori Yoshine, Suzuki Koujiro, Satake Hiroko, Ota Toyohiro, Naganawa Shinji

    Abdom Imaging   Vol. in press   2009.7

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  442. Stent-Graft Treatment for Bleeding Superior Mesenteric Artery Pseudoaneurysm After Pancreaticoduodenectomy.

    Suzuki K, Mori Y, Komada T, Matsushima M, Ota T, Naganawa S

    Cardiovasc Intervent Radiol.   Vol. 32 ( 4 ) page: 762-6   2009.7

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  443. MRIの’’今’’を知り、診断能を探る

    長縄慎二

    新医療   Vol. 6   page: 36-39   2009.6

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  444. Image evaluation of endolymphatic space in fluctuating hearing loss without vertigo.

    Teranishi Masaaki, Naganawa Shinji, Katayama Naomi, Sugiura Makoto, Nakata Seiichi, Sone Michiko, Nakashima Tsutomu

    Eur Arch Otorhinolaryngol   Vol. 266 ( 12 ) page: 1871-1877   2009.5

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  445. 3D-CT volumetry of the lung using multidetector row CT: comparison with pulmonary function tests.

    Iwano, Shingo; Okada, Tohru; Satake, Hiroko; Naganawa, Shinji

    Acad Radiol   ( 16 ) page: 205-256   2009.3

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    RATIONALE AND OBJECTIVES: The aim of this study was to evaluate the accuracy of measurements of lung volumes reconstructed using three-dimensional computed tomographic (CT) imaging from thin-section multidetector-row CT images compared to standard pulmonary function testing. MATERIALS AND METHODS: Preoperative three-dimensional CT images and pulmonary function test results of 64 patients with solitary pulmonary nodules who were considered candidates for lung resection were reviewed. On the three-dimensional CT images, total lung capacity (TLC(CTV)), emphysematous lung capacity (ELC(CTV)), and normal lung capacity (NLC(CTV)) were calculated. Total lung capacity (TLC), vital capacity, and forced expiratory volume in 1 second were measured using spirometry. RESULTS: There was a strong positive correlation between estimated TLC(CTV) and measured TLC values (r = 0.87, P < .001). Estimated ELC(CTV) at the threshold value of -900 Hounsfield units was negatively correlated with forced expiratory volume in 1 second (r = -0.56, P < .001). NLC(CTV) values were more strongly correlated with vital capacity values than TLC(CTV) values (r = 0.74, P < .001). CONCLUSIONS: Lung volume calculated using three-dimensional CT volumetry was well correlated with lung volume measured using spirometry. Three-dimensional CT volumetry can be used to evaluate pulmonary function.

  446. Visualization of Endolymphatic Hydrops in the Patients with Meniere's Disease by MR Imaglng after lntratympanic Administration of Gd-DTPA :Its Methods, Anatomy, Findings, and Clinical Application

      ( 2月 ) page: 60   2009.2

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  447. Endolymphatic Hydrops of the Labyrinth Visualized on Noncontrast MR Imaging: A Case Report.

    Naganawa, Shinji; Sone, Michihiko; Otake, Hironao; Nakashima, Tsutomu

    Magn Reson Med Sci   Vol. 8   page: 43-46   2009

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  448. Changes in endolymphatic hydrops in a patient with Meniere's disease observed using magnetic resonance imaging

    Sone Michiko, Naganawa Shinji, Teranishi Masaaki, Nakata Seiichi, Katayama Naomi, Nakashima Tsutomu

    Auris Nasus Larynx   Vol. 37 ( 2 ) page: 220-222   2009

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  449. 乳腺領域におけるReal-time Virtual Sonography の臨床的有用性について

    佐竹弘子、西尾明子、石垣聡子、川村麻里子、長縄慎二

    Jpn J Med Ultrasonics   Vol. 36 ( 6 ) page: 669-678   2009

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  450. Three-Dimensional Intravenous Digital Subtraction Angiography Using Flat Panel Detector System in Vascular Mapping of the External Carotid Artery: A Comparison with 3-Dimensional Computed Tomography Angiography.

    Yoshinori Tsutsumi, Kojiro Suzuki, Mitsuru Ikeda, Masataka Achiwa, Yoshine Mori, Masaya Matsushima, Satoko Ishigaki, Toyohiro Ota, Satoru Kondo, Kazuo Yoneda, Shinji Naganawa

    Current Medical Imaging Reviews   Vol. 5   page: 216-221   2009

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  451. Computer-aided diagnosis of lung cancer: definition and detection of ground-glass opacity type of nodules by high-resolution computed tomography.

    Okada, Tohru; Iwano, Shingo; Ishigaki, Takeo; Kitasaka, Takayuki; Hirano, Yasushi; Mori, Kensaku; Suenaga, Yasuhito; Naganawa, Shinji

    Jpn J Radiol   Vol. 27   page: 91-99   2009

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  452. Semi-automatic volumetric measurement of lung cancer using multi-detector CT effects of nodule characteristics.

    Iwano, Shingo; Okada, Tohru; Koike, Wataru; Matsuo, Keiji; Toya, Reiko; Yamazaki, Masahiro; Ito, Shinya; Ito, Junji; Naganwa, Shinji

    Acad Radiol   Vol. 16   page: 1179-1186   2009

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  453. CT, MR

    長縄慎二

    脳神経外科エキスパート 頭蓋底     page: 2-14   2009

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  454. A Phase I Study of Intraoperative Radiotherapy for Early Breast Cancer in Japan

    Masataka Sawaki , Shigenori Sato,Toyone Kikumori ,Shunichi Ishihara ,Yuichi Aoyama, Yoshiyuki Itoh ,Akimasa Nakao , Tsuneo Imai

    World J Surg   Vol. 33   page: 2587-2593   2009

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  455. Communication between cochlear perilymph and cerebrospinal fluid through the cochlear modiolus visualized after intratympanic administration of Gd-DTPA.

    Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Sone, Michihiko; Nakashima, Tsutomu

    Radiat Med   Vol. 26   page: 597-602   2009

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  456. Cutting edge of inner ear MRI

    SHINJI NAGANAWA ,TSUTOMU NAKASHIMA

    Acta Oto-Laryngologica   Vol. 129   page: 15-21   2009

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  457. Clinical significance of endolymphatic imaging after intratympanic gadolinium injection

    TSUTOMU NAKASHIMA, SHINJI NAGANAWA2, NAOMI KATAYAMA,MASAAKI TERANISHI, SEIICHI NAKATA, MAKOTO SUGIURA,MICHIHIKO SONE, SACHIO KASAI, MAYUMI YOSHIOKA& ASAKO YAMAMOTO

    Acta Oto-Laryngologica   Vol. 129   page: 9-14   2009

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  458. Grading of endolymphatic hydrops using magnetic resonance imaging

    TSUTOMU NAKASHIMA, SHINJI NAGANAWA, ILMARI PYYKKO,WILLIAM P.R. GIBSON, MICHIHIKO SONE, SEIICHI NAKATA,MASAAKI TERANISHI

    Acta Oto-Laryngologica   Vol. 129   page: 5-8   2009

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  459. Diagnostic Whole-Body Scanning Before Radioiodine Therapy for Pulmonary Metastases of Diffrentiated Thyroid Cancer. Predictve Value and Recommendations.

    Tachi Y, Iwano S, Kato K, Tadokoro M, Naganawa S

    Clin Nucl Med   Vol. 33 ( 12 ) page: 845-851   2008.12

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  460. Endovascular Management of Ruptured Pancreaticoduodenal Artery Aneurysms Associated with Celiac Axis Stenosis.

    Suzuki K, Tachi Y, Ito S, Maruyama K, Mori Y, Komada T, Matsushima M, Ota T, Naganawa S

    Cardiovasc Intervent Radiol   Vol. 31 ( 6 ) page: 1082-7   2008.11

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    The purpose of this study was to assess the efficacy of transcatheter arterial embolization for ruptured pancreaticoduodenal artery (PDA) aneurysms associated with celiac axis stenosis (CS). Seven patients (four men and three women; mean age, 64; range, 43-84) were treated with transcatheter arterial embolization between 2002 and 2007. They were analyzed with regard to the clinical presentation, radiological finding, procedure, and outcome. All patients presented with sudden epigastric pain or abdominal discomfort. Contrast-enhanced CT showed a small aneurysm and retroperitoneal hematoma around the pancreatic head in all patients. The aneurysms ranged from 0.3 to 0.9 cm in size. In one patient, two aneurysms were detected. The aneurysms were located in the pancreaticoduodenal artery (n = 5) and the dorsal pancreatic artery (n = 3). Embolization was performed with microcoils in all aneurysms (n = 8). N-Butyl 2-cyanoacrylate (n = 1) and gelatine particle (n = 1) were also used. Complete occlusion was achieved in four patients. In the other three patients, a significantly reduced flow to the aneurysm remained at final angiography. However, these aneurysms were thrombosed on follow-up CT within 2 weeks. And there was no recurrence of the symptoms and bleeding during follow-up (mean, 28 months; range, 5-65 months) in all patients. In conclusion, transcatheter arterial embolization for PDA aneurysms associated with CS is effective. Significant reduction of the flow to the aneurysm at final angiography may be predictive of future thrombosis.

  461. Arteriovenous malformation of the pancreas: assessment of clinical and multislice CT features.

    Ogawa H, Itoh S, Mori Y, Suzuki K, Ota T, Naganawa S

    Abdom Imaging.   Vol. Epub ahead of print   2008.10

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  462. 特集 地方会を考えるー地方会の意義;中部の場合ー

    長縄慎二

      Vol. 166   page: 8-9   2008.9

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  463. Three-Dimensional Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging Findings and Prognosis in Sudden Sensorineural Hearing Loss.

    Yoshida T, Sugiura M, Naganawa S, Teranishi M, Nakata S, Nakashima T.

    Laryngoscope   Vol. 118 ( 8 ) page: 1433-7   2008.8

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  464. Imaging analysis in cases with inflammation-induced sensorineural hearing loss.

    Sone Michiko, Mizuno Terukazu, Naganawa Shinji, Nakashima Tsutomu

    Acta Otolaryngol   Vol. 8   page: 1-5   2008.8

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  465. Focal inflammation in the embryological ventral pancreas: assessment using CT and MRI.

    Itoh, S; Suzuki, K; Kawai, H; Naganawa, S

    Clin Radiol   Vol. 63   page: 433-441   2008.4

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  466. Cognitive impairments in multiple system atrophy: MSA-C vs MSA-P.

    Kawai, Y; Suenaga, M; Takeda, A; Ito, M; Watanabe, H; Tanaka, F; Kato, K; Fukatsu, H; Naganawa, S; Kato, T; Ito, K; Sobue, G

    Neurology   Vol. 70   page: 1390-1396   2008.4

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    We evaluated comprehensive neuropsychological tests and regional brain blood flow to compare cognitive dysfunction between two types of multiple system atrophy: predominant cerebellar ataxia (MSA-C) and predominant parkinsonism (MSA-P). METHODS: Twenty-one patients with MSA-C, 14 patients with MSA-P, and 21 age- and education-matched control subjects were subjected to neuropsychological tests and SPECT. The neuropsychological tests examined general cognition, verbal and visual memory, working memory, visuospatial and constructional ability, language, executive function, depression, and anxiety, while SPECT analysis examined brain perfusion. RESULTS: Patients with MSA-P showed severe involvement of visuospatial and constructional function, verbal fluency, and executive function compared with control subjects. Patients with MSA-C showed involvement only in visuospatial and constructional function compared with control subjects and a milder degree of involvement compared with patients with MSA-P. Patients with MSA-P tended toward a wide and severe impairment in cognitive function compared with patients with MSA-C. In addition, neuropsychological impairment in patients with MSA-P was significantly correlated with a decrease in prefrontal perfusion. This significant relation was not correlated to other factors such as age, education, and severity of cerebellar ataxia and parkinsonism, which are relevant factors associated with cognitive performance. CONCLUSIONS: Patients with multiple system atrophy-parkinsonism show more severe and more widespread cognitive dysfunctions than patients with multiple system atrophy-cerebellar ataxia. Our results also indicate that cognitive dysfunction in patients with multiple system atrophy-parkinsonism may be associated with prefrontal involvement.

  467. *Separate visualization of endolymphatic space, perilymphatic space and bone by a single pulse sequence; 3D-inversion recovery imaging utilizing real reconstruction after intratympanic Gd-DTPA administration at 3 Tesla.

    Naganawa S, Satake H, Kawamura M, Fukatsu H, Sone M, Nakashima T

    Eur Radiol   Vol. 18 ( 5 ) page: 920-924   2008.3

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  468. *Imaging of Endolymphatic and Perilymphatic Fluid at 3T After Intratympanic Administration of Gadolinium-Diethylene-Triamine Pentaacetic Acid.

    Naganawa S, Sugiura M, Kawamura M, Fukatsu H, Sone M, Nakashima T

    AJNR Am J Neuroradiol   Vol. 29 ( 4 ) page: 724-726   2008.1

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    SUMMARY: By optimizing the inversion time of a 3D inversion-recovery turbo spin-echo sequence at 3T, we obtained separate images of endolymphatic and perilymphatic space 24 hours after intratympanic administration of gadolinium contrast material. In patients with Meniere disease, endolymphatic hydrops were detected not only in the cochlea but also in the vestibule. Fusion of the 2 types of images visualized the entire fluid space of the labyrinth and the spatial relationship of the 2 spaces.

  469. Arterial Spin Labeling(syngo ASL) Case Report from Nagoya University

    Shinji Naganawa

    MAGNETON Flash     page: 26-33   2008.1

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  470. Neuroendocrine tumor in the breast.

    Ogawa H, Nishio A, Satake H, Naganawa S, Imai T, Sawaki M, Yamamoto E, Miyata T.

    Radiat Med   Vol. 26 ( 1 ) page: 28-32   2008.1

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    A 34-year-old woman with a past history of a carcinoid tumor in the right ovary presented with a right breast mass found on contrast-enhanced computed tomography (CT) of the chest. She was asymptomatic, and her blood tests were normal. The mass measured about 2 cm. Mammography showed a lobular, circumscribed, high-density mass without microcalcifications in the upper outer quadrant of the right breast. Ultrasonography showed an irregular mass with both hypoechoic and hyperechoic components with increased vascularity. The mass was well enhanced on contrast-enhanced CT and dynamic magnetic resonance imaging. At the same time, a well-enhanced small nodule was detected in the pouch of Douglas. Both of the tumors were resected, and a primary breast neuroendocrine tumor (solid neuroendocrine carcinoma) and peritoneal dissemination of the ovarian carcinoid tumor were diagnosed.

  471. Development and evaluation of a novel lossless image compression method (AIC: artificial intelligence compression method) using neural networks as artificial intelligence.

    Fukatsu, Hiroshi; Naganawa, Shinji; Yumura, Shinnichiro

    Radiat Med   Vol. 26   page: 120-128   2008

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  472. 内耳MRIの最前線

    長縄慎二

    臨床放射線 vol.53 No.11   Vol. 23 ( 11 ) page: 1324-1333   2008

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  473. Imaging endolymphatic hydrops at 3 tesla using 3D-FLAIR with intratympanic Gd-DTPA administration.

    Naganawa, Shinji; Satake, Hiroko; Iwano, Shingo; Fukatsu, Hiroshi; Sone, Michihiko; Nakashima, Tsutomu

    Magn Reson Med Sci   Vol. 7   page: 85-91   2008

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  474. Intraductal papillary mucinous neoplasm of the pancreas: assessment of the likelihood of invasiveness with multisection CT.

    Ogawa, Hiroshi; Itoh, Shigeki; Ikeda, Mitsuru; Suzuki, Kojiro; Naganawa, Shinji

    Radiology   Vol. 248   page: 876-886   2008

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  475. Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging investigation of inner ear disturbances in cases of middle ear cholesteatoma with labyrinthine fistula

    Sone M, Mizuno T, Sugiura M, Naganawa S, Nakashima T.

    Otol Neurotol.   Vol. 28 ( 8 ) page: 1029-33   2007.12

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    To investigate the cause of inner ear disturbances in cases of middle ear cholesteatoma with labyrinthine fistula. SETTING: University hospital. STUDY DESIGN: Prospective case study. PATIENTS: Eight patients who were scheduled to undergo surgery for middle ear cholesteatoma with labyrinthine fistula were included in this study. INTERVENTION: Imaging analysis was performed using a 3-dimensional fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging sequence. MAIN OUTCOME MEASURES: Three-dimensional FLAIR findings were compared with clinical symptoms associated with inner ear disturbance and surgical observations of the fistula. RESULTS: Three-dimensional FLAIR in 6 patients revealed areas of high signal intensity in the inner ears on the affected sides and areas with increased signal after the administration of gadolinium, especially in cases accompanied by acute sensorineural hearing loss. These images were considered to be indicative of breakdown of the blood-labyrinth barrier due to middle ear cholesteatoma. This finding was also present in a patient with no clinical symptoms of inner ear disturbances. CONCLUSION: Three-dimensional FLAIR images of the inner ear are valuable in evaluating labyrinthine fistula in patients with cholesteatoma. Future studies are needed to better understand the role of 3-dimensional FLAIR in predicting the severity of inner ear disturbance.

  476. Vestibular aqueduct in sudden sensorineural hearing loss

    Sugiura M, Naganawa S, Ishida IM, Teranishi M, Nakata S, Yoshida T, Nakashima T

    J Laryngol Otol   Vol. 26   page: 1-6   2007.11

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    To evaluate the vestibular aqueduct in patients with sudden sensorineural hearing loss.Methods:We evaluated 19 patients (12 men and seven women; age range, 22-79 years) with unilateral sudden sensorineural hearing loss, using computed tomography and magnetic resonance imaging. All these patients had unilateral sudden sensorineural hearing loss. We also evaluated 47 control subjects (22 men and 25 women; age range, 22-79 years).Results:In sensorineural hearing loss affected ears, the width of the vestibular aqueduct at the midpoint and at the operculum was significantly greater than that in contralateral ears or in control ears. The width of the vestibular aqueduct at the midpoint and the operculum did not correlate with the audiometric threshold or the audiogram configuration. Contrast enhancement of the ipsilateral endolymphatic sac was observed in 17 of 19 patients with sudden sensorineural hearing loss (89 per cent). Eleven of these 17 patients also showed enhancement on the contralateral side, but no patient showed enhancement only on the contralateral side. In sensorineural hearing loss affected ears, the width of the vestibular aqueduct did not differ significantly between those patients with and without enhancement.Conclusions:The vestibular aqueducts of sudden sensorineural hearing loss affected ears are wider than those of controls. Precise imaging and evaluation of the inner ear is essential when investigating the pathological conditions responsible for sudden sensorineural hearing loss.

  477. RVS(Real-time Virtual Sonography)技術の乳腺領域への応用

    佐竹弘子、西尾明子、石垣聡子、福原理恵子、島本佳寿広、今井常夫、小田高司、菊森豊根、澤木正孝、長縄慎二

    乳癌の臨床   Vol. 22 ( 5 ) page: 438(86)-439(87)   2007.10

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  478. Comparison of 18F-FDG PET and bone scintigraphy in detection of bone metastasesof thyroid cancer. Reviewed

    Ito S, Kato K, Ikeda M, Iwano S, Makino N, Tadokoro M, Abe S, Nakano S,Nishino M, Ishigaki T, Naganawa S.

    J Nucl Med.   Vol. 48 ( 6 ) page: 889-895   2007.6

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  479. Usefulness of FDG PET for diagnosis and radiotherapy of the patient with malignant lymphoma involving bone marrow. Reviewed

    Nihashi, Takashi; Hayasaka, Kazumasa; Itou, Toshihide; Sobajima, Takashi; Kato, Rikio; Ito, Kengo; Ito, Yoshiyuki; Ishigaki, Takeo; Naganawa, Shinji

    Radiat Med   Vol. 25 ( 3 ) page: 130-4   2007.4

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    We experienced a case of relapsed malignant lymphoma with multiple bone marrow or bone lesions. The case was diagnosed as follicular lymphoma by cytological biopsy of the right iliac bone, with (67)Ga scintigraphy showing abnormal, intense uptake in multiple bones. After about 10 months of systemic chemotherapy, a relapse was suspected because of pain in the bilateral legs and a high level of lactate dehydrogenase. Assessment of the lesions in the patient was difficult by computed tomography because the affected sites were localized mainly in the bone marrow. (18)F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) was useful for detecting accurately the relapse sites in the bone marrow and enabled us to determine the field for radiotherapy. There are only a few reports of FDG-PET findings for such bone marrow malignant lymphomas. Therefore, we report the findings of FDG-PET for this case and review some of the literature about bone marrow lymphomas.

  480. Usefulness of combined fractional anisotropy and apparent diffusion coefficient values for detection of involvement in multiple system atrophy. Reviewed

    Ito, Mizuki; Watanabe, Hirohisa; Kawai, Yoshinari; Atsuta, Naoki; Tanaka, Fumiaki; Naganawa, Shinji; Fukatsu, Hiroshi; Sobue, Gen

    J Neurol Neurosurg Psychiatry   Vol. 78   page: 722-728   2007.3

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    OBJECTIVE: To determine whether apparent diffusion coefficient (ADC) values and fractional anisotropy (FA) values can detect early pathological involvement in multiple system atrophy (MSA), and be used to differentiate MSA-P (multiple system atrophy if parkinsonian features predominate) from Parkinson's disease (PD). METHODS: We compared ADC and FA values in the pons, cerebellum and putamen of 61 subjects (20 probable MSA patients, 21 age matched PD patients and 20 age matched healthy controls) using a 3.0 T magnetic resonance system. RESULTS: ADC values in the pons, cerebellum and putamen were significantly higher, and FA values lower in MSA than in PD or controls. These differences were prominent in MSA lacking dorsolateral putaminal hyperintensity (DPH) or hot cross bun (HCB) sign. In differentiating MSA-P from PD using FA and ADC values, we obtained equal sensitivity (70%) and higher specificity (100%) in the pons than in the putamen and cerebellum. In addition, all patients that had both significant low FA and high ADC values in each of these three areas were MSA-P cases, and those that had both normal FA and ADC values in the pons were all PD cases. Our diagnostic algorithm based on these results accurately diagnosed 90% of patients with MSA-P. CONCLUSION: FA and ADC values detected early pathological involvement prior to magnetic resonance signal changes in MSA. In particular, low FA values in the pons showed high specificity in discriminating MSA-P from PD. In addition, combined analysis of both FA and ADC values in all three areas was more useful than only one.

  481. 3D-FLAIR MRI findings in a patient with Ramsay Hunt syndrome. Reviewed

    Sugiura M, Naganawa S, Nakata S, Kojima S, Nakashima T

    Acta Otolaryngol   Vol. 127 ( 5 ) page: 547-549   2007

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    Three-dimensional, fluid-attenuated inversion recovery (3D-FLAIR) of magnetic resonance imaging (MRI) has recently been developed to detect hemorrhage or high concentrations of protein. We present a patient with Ramsay Hunt syndrome, in whom high signals in the cochlear and vestibular apparatus were identified with 3D-FLAIR. The high signal areas in 3D-FLAIR were not detected by T1- and T2-weighted MRI in this case. This is the first report of high concentrations of protein in the inner ear in Ramsay Hunt syndrome using 3D-FLAIR, and suggests that high concentrations of protein in the inner ear are associated with hearing deterioration in some patients with Ramsay Hunt syndrome. 3D-FLAIR could be a useful diagnostic tool in the early stages of Ramsay Hunt syndrome.

  482. *Visualization of endolymphatic hydrops in patients with Meniere's disease. Reviewed

    Nakashima T, Naganawa S, Sugiura M, Teranishi M, Sone M, Hayashi H, Nakata S, Katayama N, Ishida IM

    Laryngoscope   Vol. 117 ( 3 ) page: 415-420   2007

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    OBJECTIVE: Recently, there have been many reports of intratympanic gentamicin therapy for the treatment of intractable Meniere's disease. Intratympanic administration of steroids has also been used to treat sudden sensorineural hearing loss. We attempted to visualize how the intratympanically administered drug enters the inner ear. METHODS: Gadolinium hydrate diluted eightfold with saline was injected intratympanically through the tympanic membrane using a 23 G needle in nine patients with inner ear diseases. With a 3 Tesla magnetic resonance imaging (MRI) unit, three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) imaging was performed. RESULTS: 3D-FLAIR MRI clearly revealed that the gadolinium entered the perilymphatic space and delineated the perilymphatic and endolymphatic spaces of the inner ear. In patients with endolymphatic hydrops, the perilymphatic space surrounding the endolymph was small or had disappeared. Gadolinium appeared first in the scala tympani of the basal turn of the cochlea and the perilymphatic space of the vestibule. One day after the intratympanic injection of gadolinium, the gadolinium was observed in almost all parts of the perilymph. Six days after the intratympanic injection, the gadolinium had almost disappeared from the inner ear. CONCLUSION: We reported the first visualization of endolymphatic hydrops in patients with Meniere's disease. The relationship between the image of the endolymphatic space and functional tests, such as electrocochleography and vestibular-evoked myogenic potential, must be examined in the near future. It is important for the development of intratympanic drug therapies for inner-ear diseases to investigate how the drugs enter and leave the inner ear.

  483. 【マルチモダリティによるHead & Neck Imaging 2007 臨床編 日常臨床における戦略と選択】 側頭骨・耳(中耳・内耳・外耳) 難聴とめまいにおける画像診断の現状と進歩 名古屋大学医学部附属病院

    長縄慎二

    INNERVISION   Vol. 22   page: 8-11   2007

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    難聴、めまいは病院を訪れる主訴として非常に多い。両者を合併することもある。これらの病態の診断で最も大切なのは、言うまでもなく十分な病歴聴取である。さらに聴力検査、注視眼振検査、頭位眼振検査、温度刺激試験、下位脳神経障害や中耳炎の有無を調べる耳鼻咽喉科的一般所見などの検査で引き続き診断を進め、血液検査や他の部位の画像検査で全身疾患の有無も調べる必要がある。局所つまり側頭骨の画像検査はそれらを補完する意義を持つ。側頭骨画像診断についてはCT,MRIが最も重要な画像検査であるが、本稿では側頭骨におけるCT,MRIの撮像法の原則を述べた後、病態ごとに画像診断のポイント、最近の進歩を述べ、最後に難聴における画像診断の進め方のデシジョンツリーをシェーマとしてまとめることとする。(著者抄録)

  484. 【3T MRIの最新情報】 頭部MRIの最新情報

    長縄慎二

      Vol. 10   page: 7-11   2007

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    信号雑音比的に厳しい3D-FLAIRや拡散テンソルといった特殊なコントラストを要求すると、1.5T装置では信号雑音比の不足に悩まされる。そういった厳しい領域に挑戦していくことが、確実に3T装置の有用性を表現する方法である。3D-SPACEによるFLAIR,STIR,T1強調について述べ、最近、有用性の報告の多いsusceptibility weighted image(SWI)を紹介する。(著者抄録)

  485. 側頭骨 内耳・内耳道

    長縄慎二

    日本医学放射線学会雑誌     page: 87   2007

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  486. 肺癌の類似CT画像検索CADの初期的検討

    岩野信吾, 岡田徹, 神岡祐子, 石垣武男, 長縄慎二

    日本医学放射線学会雑誌     page: 182-183   2007

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  487. 3T MRIによる磁化率強調画像(SWI)を用いた多発性硬化症の脱髄巣を走行する静脈描出頻度の検討

    久保田誠司, 川井恒, 深津博, 長縄慎二

    日本医学放射線学会雑誌     page: 188-189   2007

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  488. 遠隔画像診断クリニックにおける業務分析と課題

    村瀬詠子, 深津恵理子, 石垣武男, 古賀佑彦, 加藤克彦, 深津博, 長縄慎二, 島本佳寿広

    日本医学放射線学会雑誌     page: 204-205   2007

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  489. 腹腔動脈狭窄に因る膵仮性動脈瘤に対するTAE

    鈴木耕次郎, 館靖, 森芳峰, 太田豊裕, 長縄慎二, 丸山邦弘, 伊藤信嗣, 白石里支

    日本医学放射線学会雑誌     page: 269   2007

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  490. Intraductal papillary mucinous neoplasm(IPMN)のマルチスライスCT所見の検討

    小川浩, 伊藤茂樹, 鈴木耕次郎, 長縄慎二

    日本医学放射線学会雑誌     page: 349   2007

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  491. 腹側膵領域の限局性炎症の画像所見

    伊藤茂樹, 鈴木耕次郎, 川井恒, 長縄慎二

    日本医学放射線学会雑誌     page: 350   2007

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  492. 鼓室内Gd注入による迷路内リンパ水腫の観察

    長縄慎二, 深津博, 川井恒

    日本医学放射線学会雑誌     page: 360   2007

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  493. 人工知能Neural Networkを用いたLossless画像圧縮方法(JIS圧縮法)の開発と評価

    深津博, 長縄慎二, 湯村眞一郎

    日本医学放射線学会雑誌     page: 383-384   2007

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  494. ネットワーク上の情報のorganic recirculation 比較CT interpretationにおける放射線科医に及ぼすその臨床的影響(Organic Recirculation of Information On Network: Its Clinical Impact for Radiologists in Comparative CT Interpretation)

    深津博, 長縄慎二, 長田雅和, 増沢高

    日本医学放射線学会雑誌     page: 384-385   2007

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  495. Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients.

    Nihashi, Takashi; Yatsuya, Hiroshi; Hayasaka, Kazumasa; Kato, Rikio; Kawatsu, Shoji; Arahata, Yutaka; Iwai, Katsushige; Takeda, Akinori; Washimi, Yukihiko; Yoshimura, Kumiko; Mizuno, Kanako; Kato, Takashi; Naganawa, Shinji; Ito, Kengo

    Radiat Med   Vol. 25   page: 225-262   2007

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    The purpose of this study was to evaluate and compare the diagnostic ability of 2-[(18)F]-fluoro-2-deoxy-D: -glucose (FDG) positron emission tomography (PET) and N-isopropyl-p-(123)I iodoamphetamine single photon emission computed tomography (IMP-SPECT) using three-dimensional stereotactic surface projections (3D-SSP) in patients with moderate Alzheimer's disease (AD). MATERIALS AND METHODS: FDG-PET and IMP-SPECT were performed within 3 months in 14 patients with probable moderate AD. Z-score maps of FDG-PET and IMP-SPECT images of a patient were obtained by comparison with data obtained from control subjects. Four expert physicians evaluated and graded the glucose hypometabolism and regional cerebral blood flow (rCBF), focusing in particular on the posterior cingulate gyri/precunei and parietotemporal regions, and determined the reliability for AD. Receiver operating characteristic (ROC) curves were applied to the results for clarification. To evaluate the correlation between two modalities, the regions of interest (ROIs) were set in the posterior cingulate gyri/precunei and parietotemporal region on 3D-SSP images, and mean Z-values were calculated. CONCLUSION: No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).

  496. Risk factors for neovascular glaucoma after carbon ion radiotherapy of choroidal melanoma using dose-volume histogram analysis. Reviewed

    Hirasawa, Naoki; Tsuji, Hiroshi; Ishikawa, Hitoshi; Koyama-Ito, Hiroko; Kamada, Tadashi; Mizoe, Jun-Etsu; Ito, Yoshiyuki; Naganawa, Shinji; Ohnishi, Yoshitaka; Tsujii, Hirohiko

    Int J Radiat Oncol Biol Phys   Vol. 67   page: 538-543   2007

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    PURPOSE: To determine the risk factors for neovascular glaucoma (NVG) after carbon ion radiotherapy (C-ion RT) of choroidal melanoma. METHODS AND MATERIALS: A total of 55 patients with choroidal melanoma were treated between 2001 and 2005 with C-ion RT based on computed tomography treatment planning. All patients had a tumor of large size or one located close to the optic disk. Univariate and multivariate analyses were performed to identify the risk factors of NVG for the following parameters; gender, age, dose-volumes of the iris-ciliary body and the wall of eyeball, and irradiation of the optic disk (ODI). RESULTS: Neovascular glaucoma occurred in 23 patients and the 3-year cumulative NVG rate was 42.6 +/- 6.8% (standard error), but enucleation from NVG was performed in only three eyes. Multivariate analysis revealed that the significant risk factors for NVG were V50IC (volume irradiated > or =50 GyE to iris-ciliary body) (p = 0.002) and ODI (p = 0.036). The 3-year NVG rate for patients with V50IC > or =0.127 mL and those with V50IC <0.127 mL were 71.4 +/- 8.5% and 11.5 +/- 6.3%, respectively. The corresponding rate for the patients with and without ODI were 62.9 +/- 10.4% and 28.4 +/- 8.0%, respectively. CONCLUSION: Dose-volume histogram analysis with computed tomography indicated that V50IC and ODI were independent risk factors for NVG. An irradiation system that can reduce the dose to both the anterior segment and the optic disk might be worth adopting to investigate whether or not incidence of NVG can be decreased with it.

  497. Contrast enhanced MR imaging of the brain using T1-FLAIR with BLADE compared with conventional spin echo sequence

    S.Naganawa,H.Kawai,and H.Fukatsu

    Proc.Intl.Soc.Mag.Reson.Med   Vol. 15   page: 2110   2007

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  498. 拡散テンソル画像を用いた多系統萎縮症とパーキンソン病の錐体路評価

    伊藤瑞規, 熱田直樹, 川合圭成, 渡邉宏久, 祖父江元, 長縄慎二, 深津博, 石垣武男

    臨床神経学   Vol. 46   page: 1084   2007

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  499. Parry-Romberg syndrome with a clinically silent white matter lesion. Reviewed

    Okumura A, Ikuta T, Tsuji T, Kato T, Fukatsu H, Naganawa S, Kato K, Watanabe K

    AJNR Am J Neuroradiol   Vol. 27 ( 8 ) page: 1729-1731   2006.9

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    We performed a detailed neuroimaging study in a patient with Parry-Romberg syndrome. Proton MR spectroscopy demonstrated normal spectral patterns, though conventional MR imaging revealed high-intensity areas in the entire white matter in the left hemisphere. Single-photon emission tomography showed increased perfusion in the cortex of the affected hemisphere. Pyramidal tracts and optic radiations were preserved on diffusion tensor tractography. We will correlate these neuroimaging findings with normal psychomotor development in our patient.

  500. Prompt contrast enhancement of cerebrospinal fluid space in the fundus of the internal auditory canal: observations in patients with meningeal diseases on 3D-FLAIR images at 3 Tesla. Reviewed

    Naganawa S, Sugiura M, Kawamura M, Fukatsu H, Nakashima T, Maruyama K

    Magn Reson Med Sci   Vol. 5 ( 3 ) page: 151-155   2006

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    We speculated that meningeal pathologies might facilitate the permeability of cranial nerves at the fundus of the internal auditory canal (IAC), causing prompt enhancement after administration of Gd-DTPA. Using a 3D- fluid-attenuated inversion recovery (FLAIR) sequence, we evaluated the enhancement of the cerebrospinal fluid (CSF) space in the IAC fundus 10 min after Gd-DTPA administration in patients with meningeal diseases. Twenty patients (aged 22 to 79 years) were divided into 2 groups, a group with meningeal disease comprising 9 patients with meningeal abnormalities (6, tumor dissemination; 3, infection) and a control group of 11 patients with unilateral IAC pathology whose healthy sides were included as controls. Six of the 9 patients in the group with meningeal disease showed bilateral enhancement; one showed unilateral enhancement. None of the control group showed enhancement in the healthy side. One patient with Ramsay-Hunt syndrome showed only ipsilateral enhancement. Enhancement in the IAC fundus was frequently observed in patients with meningeal disease, even just 10 min after administration of contrast agent. This enhancement in the IAC fundus was never visible on T1-weighted 3D-FLASH images.

  501. *Observation of contrast enhancement in the cochlear fluid space of healthy subjects using a 3D-FLAIR sequence at 3 Tesla. Reviewed

    Naganawa S, Komada T, Fukatsu H, Ishigaki T, Takizawa O

    Eur Radiol   Vol. 16 ( 3 ) page: 733-737   2006

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    In animals, the enhancement of perilymph in the cochlea has been reported using 1.25 mmol/kg of Gd-DTPA, allowing the separate visualisation of perilymph and endolymph for the diagnosis of Meniere's disease. The purpose of this study was three-fold: (1) to determine the optimal timing for detecting cochlear fluid enhancement using 3D-FLAIR (fluid-attenuated inversion recovery) after intravenous administration of 0.1 mmol/kg of Gd-DTPA in healthy human subjects; (2) to examine the reliability of enhancement in multiple healthy subjects; and (3) to investigate whether endolymph and perilymph space can be visually discriminated. In two healthy subjects, 3D-FLAIR images were obtained before, immediately after and 2 h, 4 h and 6 h after the injection. Three more healthy subjects were scanned before and 4 h after the injection. In all four ears of the initial two subjects, cochlear fluid was found to be most intensely enhanced 4 h after the injection. In all of the additional three subjects, the cochlear fluid signal had increased after 4 h from injection. However, visual differentiation of endolymph and perilymph fluid could not be achieved. Using 3D-FLAIR and Gd-DTPA, cochlear fluid enhancement can be observed in healthy human ears, even with a single dose of contrast-medium injection.

  502. Relationship between CT densitometry with a slice thickness of 0.5 mm and audiometry in otosclerosis. Reviewed

    Kawase S, Naganawa S, Sone M, Ikeda M, Ishigaki T

    Eur Radiol   Vol. 16 ( 6 ) page: 1367-1373   2006

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    The appropriate cutoff Hounsfield unit (HU) value for the diagnosis of otosclerosis was determined and the correlation between the bone conduction threshold and the findings of computed tomography (CT) densitometry investigated. CT images, 0.5-mm thick, were evaluated in 24 ears with otosclerosis and 19 control ears. Eight regions of interest were set around the otic capsule. The mean HU values in the area anterior to the oval window (A-OW) and anterior to the internal auditory canal (A-IAC) were significantly lower in otosclerosis than in controls. Based on receiver operating characteristic (ROC) analysis, the cutoff HU value in A-OW was determined to be 2,187.3 HU. The mean HU value in retrofenestral otosclerosis was significantly lower in the area A-OW, A-IAC and around the cochlea than in controls. Based on ROC analysis, the cutoff HU value in the latter was determined to be 2,045 HU. A statistically significant correlation was found between the density of the area A-OW and the hearing level at 500 and 1,000 Hz, and between the density of the area around the cochlea and the hearing level at most frequencies. These results suggest the semi-automated diagnosis of otosclerosis may be possible.

  503. Blood flow to the promontory in cochlear otosclerosis. Reviewed

    Nakashima T, Sone M, Fujii H, Teranishi M, Yamamoto H, Otake H, Sugiura M, Naganawa S

    Clin Otolaryngol   Vol. 31 ( 2 ) page: 110-115   2006

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    OBJECTIVE: To investigate Schwartze sign with measurements of blood flow to the promontory in patients with cochlear otosclerosis. DESIGN: Prospective clinical study. SETTING: Tertiary referral centre. PARTICIPANTS: Five patients with cochlear otosclerosis and five control subjects. Significant decalcification around the cochlea was observed by computed tomography (CT) in patients with cochlear otosclerosis. However, no recognizable lesion was observed at the oval window in two patients. One patient had mixed hearing loss and four patients had sensorineural hearing loss without an air-bone gap. Main outcome measures: The relationship between CT findings and the presence or absence of Schwartze sign was investigated. Blood flow to the promontory was measured through the tympanic membrane using laser speckle flowgraphy and laser Doppler flowmetry. Results: The Schwartze sign correlated significantly with otosclerotic lesions invading the promontory. Patients with otosclerosis exhibited elevated and pulsating blood flow to the promontory with the Schwartze sign. CONCLUSIONS: Computed tomography demonstrated that cochlear otosclerosis can exist without the oval window lesion. Schwartze sign can be used as a sign of the otosclerotic invasion to the promontory. The reddening of the Schwartze sign is likely due to increased blood flow.

  504. Visualization of a high protein concentration in the cochlea of a patient with a large endolymphatic duct and sac, using three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging. Reviewed

    Sugiura M, Naganawa S, Sato E, Nakashima T

    J Laryngol Otol   Vol. 120 ( 120 ) page: 1084-1086   2006

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  505. Inner ear hemorrhage in systemic lupus erythematosus. Reviewed

    Sugiura M, Naganawa S, Teranishi M, Sato E, Kojima S, Nakashima T

    Laryngoscope   Vol. 116 ( 5 ) page: 826-828   2006

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    A 33-year-old man had systemic lupus erythematosus (SLE) with anticardiolipin antibody. At the age of 40 years, he experienced bilateral hearing deterioration. The three-dimensional fluid-attenuated inversion recovery of magnetic resonance imaging showed high signals bilaterally in the cochlea and vestibule. He was diagnosed with bilateral inner ear hemorrhage on the basis of the presence of anticardiolipin antibody. This is the first published case of inner ear hemorrhage in a patient with SLE. Our findings suggest that inner ear hemorrhage is associated with hearing deterioration in some patients with SLE.

  506. Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging findings in patients with sudden sensorineural hearing loss. Reviewed

    Sugiura M, Naganawa S, Teranishi M, Nakashima T

    Laryngoscope   Vol. 116 ( 8 ) page: 1451-1454   2006

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    OBJECTIVE: To evaluate the inner ear in sudden sensorineural hearing loss (SNHL) using three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) magnetic resonance imaging (MRI) at 3 Tesla (T). BACKGROUND: 3D-FLAIR MRI has recently been developed to detect high concentrations of protein or hemorrhage. Application of this method to sudden SNHL has not been described. METHODS: We used 3D-FLAIR at 3 T with and without gadolinium enhancement to evaluate eight patients with sudden SNHL. RESULTS: In four of eight ears with idiopathic sudden SNHL, high precontrast signals were observed within the inner ear on 3D-FLAIR. The high-signal areas observed on 3D-FLAIR were not detected by T1- or T2-weighted MRI in any of these patients. In one of these four ears, significant gadolinium enhancement was observed on 3D-FLAIR. CONCLUSION: Half the patients with sudden SNHL examined had high signals in the SNHL-affected ear on 3D-FLAIR at 3 T. High precontrast signals in the inner-ear fluid space may reflect minor hemorrhage, or an increased concentration of protein that had passed through blood vessels with increased permeability, or had originated from disrupted cells in the inner ear. Gadolinium enhancement in one ear suggested the breakdown of the blood-labyrinth barrier. 3D-FLAIR MRI should contribute markedly to the elucidation of pathologic conditions in the inner ears of patients with idiopathic sudden SNHL.

  507. Lateral semicircular canal and vertigo in patients with large vestibular aqueduct syndrome. Reviewed

    Ishida IM, Sugiura M, Nakashima T, Naganawa S, Sato E, Sugiura J, Yoshino T

    Otol Neurotol   Vol. 27 ( 6 ) page: 788-792   2006

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    OBJECTIVE: To evaluate the hypothesis that there are differences in the morphology of the lateral semicircular canal (LSCC) between patients with large vestibular aqueduct syndrome (LVAS) and control subjects and to investigate the clinical implications of these differences. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. PATIENTS: Nine patients (two male patients and seven female patients; age range, 8-54 yr) with LVAS (one patient had unilateral LVAS, and eight patients had bilateral LVAS). Five patients had vertigo, and four patients, including the one with unilateral LVAS, did not have vertigo. MAIN OUTCOME MEASURES: The area of the LSCC was traced on the magnetic resonance imaging console and compared between LVAS patients and 12 control subjects who did not have sensorineural hearing loss. The LSCC fluid-containing area was divided by the sum of the LSCC inner area and the LSCC fluid-containing area for evaluation of the degree of the LSCC dysplasia. RESULTS: The LSCC fluid-containing ratio was significantly larger in LVAS patients than in control subjects. Moreover, the LSCC fluid-containing ratio was significantly larger in the eight ears with vertigo than in the nine ears without vertigo. There was no relationship between hearing level and the LSCC fluid-containing ratio. CONCLUSION: Patients with LVAS may have disturbed morphogenesis of both membranous and bony labyrinths. Our results reveal that the morphology of semicircular canals is clinically associated with vertigo.

  508. 3D-FLAIR magnetic resonance imaging in the evaluation of mumps deafness. Reviewed

    Otake H, Sugiura M, Naganawa S, Nakashima T

    Int J Pediatr Otorhinolaryngol   Vol. 70 ( 12 ) page: 2115-2117   2006

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    A 6-year-old boy suffered acute profound right side deafness after his classmates had mumps. Although his salivary glands were not swollen, he had high levels of anti-mumps IgM and IgG antibodies. The three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) procedure applied to magnetic resonance imaging (MRI) showed high signals in the right cochlea and vestibule. This indicated hemorrhage or a high concentration of protein in the right inner ear. This is the first case demonstrating a high 3D-FLAIR MRI signal of the inner ear in a patient with mumps deafness. Our findings suggest that 3D-FLAIR MRI may help to identify and define labyrinthitis in mumps deafness.

  509. 【超音波画像診断の最新技術と臨床活用 最新技術をキーワードで斬る】 RVS RVS(Real-time Virtual Sonography)技術の乳腺領域への臨床応用

    佐竹弘子, 澤木明子, 長縄慎二, 三竹毅, 荒井修

      Vol. 6   page: 56-59   2006

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  510. 拡散テンソル画像を用いた多系統萎縮症の錐体路評価

    伊藤瑞規, 熱田直樹, 渡邉宏久, 祖父江元, 長縄慎二, 深津博, 石垣武男

    臨床神経学   Vol. 46   page: 110   2006

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  511. 非造影検査でどこまで診断に迫れるか? 高磁場MRI

    長縄慎二

    断層映像研究会雑誌   Vol. 33   page: 20-21   2006

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  512. 3Teslaにおける3D-FLAIRを用いた蝸牛リンパ液の造影効果の観察

    長縄慎二, 深津博, 石垣武男

    日本医学放射線学会雑誌     page: 263   2006

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  513. 【脊髄小脳変性症研究の最近の進歩】 孤発性脊髄小脳変性症 多系統萎縮症のMRI画像

    渡辺宏久, 伊藤瑞規, 熱田直樹, 長縄慎二, 深津博, 祖父江元

    神経研究の進歩   Vol. 50   page: 397-407   2006

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  514. 【ここまで進歩した3D画像システム】 臨床での効果が大きい3D画像診断 画像診断機器の進歩でもたらされた3D画像の有用性 3テスラMRIを中心に

    長縄慎二

    新医療   Vol. 33   page: 102-104   2006

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  515. 【3D-SPACEの臨床応用】 さまざまなコントラストのisotropic data撮像

    長縄慎二

      Vol. 21   page: 02-04   2006

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  516. 【64列CTがもたらした影響を検証する】 CTがもたらした診療・経営への効果 64スライスCTの普及がもたらす画像診断の進歩と機器運用の変化

    長縄慎二

    新医療   Vol. 33   page: 56-59   2006

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  517. 著明な肉芽形成が見られた腫瘤形成性膵炎の一例

    中根俊樹, 鈴木耕次郎, 長縄慎二, 伊藤茂樹, 金住直人, 下山芳江

    日本医学放射線学会雑誌     page: 465   2006

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  518. マルチスライスCTによる無症候性の腹腔動脈狭窄の検討

    森芳峰, 鈴木耕次郎, 佐竹弘子, 太田豊裕, 長縄慎二, 伊藤茂樹

    日本医学放射線学会雑誌     page: 472   2006

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  519. Medical Image Processing & Analysis Technology デジタル時代の医用画像情報技術セミナー イメージング&応用編 医療情報が拓く新しい世界 近未来型画像診断レポートシステムの最先端

    深津博, 石垣武男, 長縄慎二, 岩朝昭, 長田雅和, 牧野恭子, 早川ルミ

      Vol. 21   page: 58-63   2006

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    近年、画像診断の機器および技術の進歩はめざましく、得られた画像はほぼすべての領域において、客観的で具体的な診断情報を提供する重要なツールとなっている。しかしながら一方で、マルチスライスCTをはじめとする高速な診断機器の登場によって1検査あたりの画像が1500枚を超えるような大量のデータが日常的に発生している。また、最新のMRIやPETのように、画像の解釈に専門的な機器や物理的・化学的な知識が要求されることも珍しくない。検査をオーダする臨床医は、画像診断の結果を患者やその家族に説明したり、その結果から治療方針を決定する。さらに、治療した結果の効果判定を行い次の治療方針を立てたりすることを日常的に行っており、その際、診断内容に関して完全に理解していないと自信を持って次の行為を行うことができない。外来診療での短い診察時間内で、上記のような大量で複雑な画像情報を一から観察して解釈することは、現実的には不可能なため、放射線科医の診断レポートが必要となる。放射線科医は、専門的な知識や技術をもってすべての画像を観察して解釈し、その結果を診断レポートとしてまとめて臨床医に提供する。診断レポートはカルテの一部となる公式文書であるため、医療訴訟の際にも証拠として扱われる重要な文書である。放射線科医は診断レポート内において、所見の存在やその意義、重要性や確信度、鑑別診断や次に必要とされる処置・検査などについてのアドバイスなどを含め、その診断内容を正確に伝達することに細心の注意を払っているが、短い診療時間内で診断レポートを読んだだけでは、記載された所見に対応する画像を捜し出すのは容易ではない。本稿では、雑多な日常業務の中で行われる診断レポート作成を支援するために、われわれが開発した「Hyperlink Report」、「Report Checker」の有用性について述べる。(著者抄録)

  520. 【膵疾患の画像診断 最近のトレンド】 マルチスライスCT診断

    伊藤茂樹, 石垣聡子, 鈴木耕次郎, 岩野信吾, 長縄慎二

    臨床画像   Vol. 22   page: 1334-1342   2006

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  521. シーメンス旭 超高磁場MRIシステムの現状と将来

    長縄慎二

    Japan medical society   Vol. 112 ( 2 ) page: 75-77   2006

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  522. クローズアップ 名古屋大学医学部附属病院

    長縄慎二,深津博、米田和夫

    新医療   Vol. 33 ( 9 ) page: 87-87   2006

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  523. 画像診断機器の進歩での3D画像の有用性 3テスラMRIを中心に

    長縄慎二

    新医療   Vol. 33 ( 8 ) page: 102-104   2006

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  524. Diffusion-weighted imaging of the liver: technical challenges and prospects for the future.

    Naganawa S, Kawai H, Fukatsu H, Sakurai Y, Aoki I, Miura S, Mimura T, Kanazawa H, Ishigaki T.

    Magn Reson Med Sci.   Vol. 4 ( 4 ) page: 175-186   2005.12

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    Diffusion-weighted imaging (DWI) has recently been attempted in the abdominal region. We review diffusion-weighted images of the liver, especially from the technical point of view. We discuss selection of pulse sequence parameters, effects of anti-breathing motion technique, tips for measuring apparent diffusion coefficient (ADC), and utility of superparamagnetic iron oxide (SPIO), showing clinical cases, including those at 3T. Our current trial of new pulse sequencing, such as SPIO-mediated breath-holding black-blood fluid-attenuated inversion recovery (BH-BB-FLAIR), imaging is shown. Some prospects for the future in DWI of the liver are also stated.

  525. *Differentiation of noncancerous tissue and cancer lesions by apparent diffusion coefficient values in transition and peripheral zones of the prostate. Reviewed

    Sato C, Naganawa S, Nakamura T, Kumada H, Miura S, Takizawa O, Ishigaki T

    J Magn Reson Imaging   Vol. 21 ( 3 ) page: 258-262   2005.3

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    PURPOSE: To compare the apparent diffusion coefficient (ADC) values of prostate cancer in both the peripheral zone (PZ) and the transition zone (TZ) with those of benign tissue in the same zone using echo-planar diffusion weighted imaging with a parallel imaging technique. MATERIALS AND METHODS: A total of 29 consecutive male patients (mean age 61.3 years, age range 53-88 years) with suspected prostate cancer were referred for MR imaging. All patients underwent transrectal ultrasound (TRUS)-guided biopsy of the prostate after MR imaging at 1.5 T, including ADC. For each patient, seven to 10 specimens were obtained from the prostate, and regions of interest (ROIs) were drawn on the ADC map by referring to the urologist's illustration of TRUS-guided biopsy sites. ADC values of cancerous tissue in both the PZ and TZ were compared to those of noncancerous tissue in the same zone. RESULTS: Out of 29 patients, 23 had cancer tissue. In the 23 patients with cancer, the mean ADC value of all cancer ROIs and that of all noncancer ROIs, respectively, were 1.11 +/- 0.41 x 10(-3) and 1.68 +/- 0.40 x 10(-3) mm(2)/second (values are mean +/- SD) (P < 0.01). The mean ADC value of TZ cancer ROIs and that of TZ noncancer ROIs, respectively, were 1.13 +/- 0.42 x 10(-3) and 1.58 +/- 0.37 x 10(-3) mm(2)/second (P < 0.01). CONCLUSIONS: ADC measurement with a parallel imaging technique showed that ADC values of prostate cancer in both the PZ and TZ were significantly lower than those of benign tissue in the PZ and TZ, respectively.

  526. Diffusion-weighted imaging of the liver: technical challenges and prospects for the future. Reviewed

    Naganawa S, Kawai H, Fukatsu H, Sakurai Y, Aoki I, Miura S, Mimura T, Kanazawa H, Ishigaki T

    Magn Reson Med Sci   Vol. 4 ( 4 ) page: 175-186   2005

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    Diffusion-weighted imaging (DWI) has recently been attempted in the abdominal region. We review diffusion-weighted images of the liver, especially from the technical point of view. We discuss selection of pulse sequence parameters, effects of anti-breathing motion technique, tips for measuring apparent diffusion coefficient (ADC), and utility of superparamagnetic iron oxide (SPIO), showing clinical cases, including those at 3T. Our current trial of new pulse sequencing, such as SPIO-mediated breath-holding black-blood fluid-attenuated inversion recovery (BH-BB-FLAIR), imaging is shown. Some prospects for the future in DWI of the liver are also stated.

  527. Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix. Reviewed

    Naganawa S, Sato C, Kumada H, Ishigaki T, Miura S, Takizawa O

    Eur Radiol   Vol. 15 ( 1 ) page: 71-78   2005

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    A relation between apparent diffusion coefficient (ADC) values and tumor cellular density has been reported. The purpose of this study was to measure the ADC values of cervical cancers in the uterus and compare them with those of normal cervical tissues, and to test whether ADC could differentiate between normal and malignant cervical tissues in the uterus. Twelve consecutive female patients with cervical cancer of the uterus and ten female patients with other pelvic abnormalities were included in this study. ADC was measured at 1.5 T with b-factors of 0, 300 and 600 s/mm2 using single-shot echo-planar diffusion-weighted imaging and a parallel imaging technique. The mean ADC value of cervical cancer lesions was 1.09+/-0.20 x 10(-3) mm2/s, and that of normal cervix tissue was 1.79+/-0.24 x 10(-3) mm2/s (P<0.0001). In nine patients treated by chemotherapy and/or radiation therapy, the mean ADC value of the cervical cancer lesion increased significantly after therapy (P<0.001). The present study showed, with a small number of patients, that ADC measurement has a potential ability to differentiate between normal and cancerous tissue in the uterine cervix. Further study is necessary to determine the accuracy of ADC measurement in monitoring the treatment response.

  528. Long-term follow-up in patients with Pendred syndrome: vestibular, auditory and other phenotypes. Reviewed

    Sugiura M, Sato E, Nakashima T, Sugiura J, Furuhashi A, Yoshino T, Nakayama A, Mori N, Murakami H, Naganawa S

    Eur Arch Otorhinolaryngol   Vol. 262 ( 9 ) page: 737-743   2005

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    Fourteen patients with a Pendred syndrome gene (Pds) mutation and three patients without the mutation were studied to evaluate long-term vestibular and auditory manifestations among patients with bilateral enlarged vestibular aqueducts (EVA). Charts were reviewed retrospectively for age, gender, otological history, presence or absence of vertigo, results of magnetic resonance imaging, relevant gene mutations and perchlorate discharge test. A missense mutation, His 723 Arg (H723R), was identified in the homozygous state in six patients and in the heterozygous state in seven patients. Another missense mutation, Tyr 410 Met (T410 M), was identified in the heterozygous state in one patient. Patients with vertigo tended to have hearing fluctuation, compared with the patients without vertigo. Patients homozygous for H723R tended to have more episodes of vertigo than the heterozygous individuals. Only one patient who was homozygous for H723R had goiter. The long-term outcome of hearing level in patients with the H723R mutation was significantly better compared with published results for patients with a Pds mutation, but not for those with the H723R mutation. Whether environmental factors or a subtype of the Pds mutation H723R are related to the long-term outcome for these patients must be clarified.

  529. Contralateral and ipsilateral responses in primary somatosensory cortex following electrical median nerve stimulation--an fMRI study. Reviewed

    Nihashi T, Naganawa S, Sato C, Kawai H, Nakamura T, Fukatsu H, Ishigaki T, Aoki I

    Clin Neurophysiol   Vol. 116 ( 4 ) page: 842-848   2005

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    OBJECTIVE: Ten healthy adult subjects were examined using functional magnetic resonance imaging (fMRI) to investigate responses in the contralateral and ipsilateral primary somatosensory cortex (SI) following electrical stimulation of the median nerve. METHODS: The right and left median nerves were stimulated alternately at the wrist in the different sessions. First, the location of the response in contralateral SI was identified following median nerve stimulation, and then, a spherical search volume with a 10mm radius centered on the region of the contralateral response was determined. Whether or not fMRI activation occurred within this sphere following ipsilateral stimulation was examined using a 3T MR imager. RESULTS: A response in contralateral SI was observed in 8 of the 10 subjects in right and left hemisphere. Responses in ipsilateral SI were observed in 6 of 8 subjects in right hemisphere, and the region of the response tended to be posterior to the contralateral region. On the other hand, in left hemisphere, the ipsilateral responses were found in three. CONCLUSIONS: In the present study, not only contralateral SI but also ipsilateral SI was activated following median nerve. The location of the ipsilateral activation was significantly more posterior than the contralateral one in right hemisphere. SIGNIFICANCE: The region of activation in ipsilateral SI was located in the posterior portion of post central gyrus, corresponding to around BA2 and 5 in human.

  530. Sudden sensorineural hearing loss associated with inner ear anomaly. Reviewed

    Sugiura M, Nakashima T, Naganawa S, Otake Y, Mukaida T, Sone M, Sato E

    Otol Neurotol   Vol. 26 ( 2 ) page: 241-246   2005

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    OBJECTIVE: This study was conducted to evaluate the frequency of inner ear anomaly in patients with sudden sensorineural hearing loss and in control subjects. STUDY DESIGN: Retrospective case review. SETTING: A tertiary referral center. PATIENTS AND INTERVENTION: We evaluated 366 patients (165 men and 201 women; age range, 3-91 yr) with sudden sensorineural hearing loss and 228 control subjects without sensorineural hearing loss using magnetic resonance imaging. Three hundred fifty-six patients had unilateral and 10 patients had bilateral sudden sensorineural hearing loss. RESULTS: Eleven (2.9%) of 376 ears with sudden sensorineural hearing loss had inner ear anomaly. Nine patients (2.5%) had inner ear anomaly associated with sudden sensorineural hearing loss, but none of the 228 control subjects had the anomaly. The current study demonstrated that the frequency of inner ear anomaly in patients with sudden sensorineural hearing loss was significantly higher than in control subjects. CONCLUSION: Our study reveals that inner ear anomaly may be associated with sudden sensorineural hearing loss in 2.5% of patients.

  531. Diffusion-weighted images of the liver: comparison of tumor detection before and after contrast enhancement with superparamagnetic iron oxide.

    Naganawa S, Sato C, Nakamura T, Kumada H, Ishigaki T, Miura S, Maruyama K, Takizawa O

    J Magn Reson Imaging   Vol. 21 ( 6 ) page: 836-840   2005

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    PURPOSE: To study the recognition of malignant lesions of the liver on diffusion-weighted images (DWI) can be improved by the administration of superparamagnetic iron oxide (SPIO). MATERIALS AND METHODS: Pre- and post-SPIO mediated DWI of the liver was compared in six patients with suspected malignant liver lesions at 1.5 Tesla using a parallel imaging technique. RESULTS: Post-SPIO DWI showed improved contrast-to-noise ratio between malignant lesions and liver. Furthermore, the spleen signal was decreased on post-SPIO DWI, thus avoiding the overlap of the spleen and left lobe of the liver on maximum intensity projections (MIP). CONCLUSION: Recognition of malignant lesions of the liver was improved by SPIO on DWI. On MIP images of DWI, SPIO helped to decrease the overlap of spleen signal on the liver in some projection angles.

  532. Hearing loss in patients with enlarged vestibular aqueduct: air-bone gap and audiological Bing test. Reviewed

    Mimura T, Sato E, Sugiura M, Yoshino T, Naganawa S, Nakashima T

    Int J Audiol   Vol. 44 ( 8 ) page: 466-469   2005

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    The Bing test is based on the principle that occlusion of the external auditory meatus improves the perception of bone-conducted sounds unless there is a conductive hearing impairment. An air-bone gap has been reported in patients with large vestibular aqueduct (LVA) syndrome without apparent middle ear dysfunction. We therefore performed the Bing test on nine patients with this syndrome to evaluate whether it is associated with an air-bone gap or middle ear dysfunction. Bone conduction thresholds did not change significantly during the Bing test in any patient. Because an air-bone gap is observed in patients with abnormal communication between the inner ear and cerebrospinal fluid through the LVA, dehiscent superior canal, or dilated inner ear meatus; we propose that a 'three windows' model (in which the abnormal communication provided by the enlarged endolymphatic duct and sac in LVA acts as the 'third window' for sound conductance) might explain the air-bone gap in such patients.

  533. 【最近の画像診断の進歩 CT,MRI,PET】 高磁場MRI

    長縄慎二

    日本医師会雑誌   Vol. 134   page: 1722-1726   2005

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  534. 電子ポスター(Cypos)元年 JRC2005を振り返って

    石垣武男 藤田広志 深津博 長縄慎二 片渕哲朗 原武史

    Innervision   Vol. 20 ( 7 ) page: 28-33   2005

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  535. 第64回日本医学放射線学会学術集会 イメージインタープリテーションセッション症例出題集

    長縄慎二、原真咲

    日本医学放射線学会誌別冊付録   Vol. 65 ( 3 ) page: 1-28   2005

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  536. 第64回日本医学放射線学会学術集会 イメージインタープリテーションセッション症例出題集

    長縄慎二、原真咲

    日本医学放射線学会誌別冊付録   Vol. 65 ( 2 ) page: 1-14   2005

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  537. 【医療環境の変化に対して放射線診療は今後どう対応すべきか 画像診断を中心に】 高度画像診断機器導入による画像診断へのインパクト 医療制度の変化を踏まえて 超高磁場MRIのインパクト(3T MRIを含めて) 脳以外への活用方法

    長縄慎二

    日独医報   Vol. 50   page: 479-489   2005

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  538. 多発性硬化症におけるIsotropic 3D FLAIR法の有用性

    末永正機, 伊藤瑞規, 熱田直樹, 渡邉宏久, 祖父江元, 深津博, 長縄慎二

    臨床神経学   Vol. 45   page: 1035   2005

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  539. 多系統萎縮症とパーキンソン病の鑑別 橋の拡散テンソル画像,拡散強調画像の有用性

    伊藤瑞規, 熱田直樹, 川合圭成, 渡邉宏久, 祖父江元, 長縄慎二, 深津博, 石垣武男

    臨床神経学   Vol. 45   page: 1168   2005

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  540. 多系統萎縮症における認知機能障害 画像との関連

    川合圭成, 伊藤瑞規, 渡邉宏久, 祖父江元, 武田章敬, 長縄慎二, 深津博, 加藤克彦, 石垣武男

    臨床神経学   Vol. 45   page: 1185   2005

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  541. 前立腺癌,子宮頸癌におけるADC測定の意義