論文 - 鈴木　弘美

Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions.

IMAI F, SAWADA M, SUZUKI H, ZLOKOVIC BV, KOJIMA J, KUNO S, NAGATSU T, NITATORI T, UCHIYAMA Y, KANNNO T

Neuroscience Letters   272 巻 ( 2 ) 頁： 127-130   1999年9月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions

F Imai, M Sawada, H Suzuki, BV Zlokovic, J Kojima, S Kuno, T Nagatsu, T Nitatori, Y Uchiyama, T Kanno

NEUROSCIENCE LETTERS   272 巻 ( 2 ) 頁： 127 - 130   1999年9月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCI IRELAND LTD  

We compared migration of systemically injected microglia into normal brain vs. ischaemic brain using a model of ischaemic hippocampal lesion. Microglia were labeled by a fluorescent dye using our standard phagocytosis procedure of microscopic particles and then injected intra-arterially into Mongolian gerbils subjected to ischaemia reperfusion neuronal injury. Delayed death of pyramidal neurons was confirmed by conventional histological analysis and dUTP nick end labeling (TUNEL) method. Clusters of dye-tagged cells migrating into the hippocampal ischaemic lesions were confirmed histochemically to be microglia. Since peripherally injected microglia exhibit specific affinity for ischaemic brain lesions and does not exacerbate ischaemic neuronal injury in the present model, we suggest that microglia may have a potential to be used as a piggy-back ride to deliver therapeutic genes and/or drugs for CNS repair following transitory global ischaemic insult. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0304-3940(99)00592-3

Web of Science

PubMed

Brain-specific gene expression by immortalized microglia cell-mediated gene transfer in the mammalian brain

SAWADA M, IMAI F, SUZUKI H. HAYAKAWA M, KANNO T, NAGATSU T

FEBS Letters   433 巻 ( 1-2 ) 頁： 37-40   1998年8月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Migration activity of microglia and macrophages into rat brain.

IMAI F, SAWADA M, SUZUKI H, KIYA N, HAYAKAWA M,NAGATSU T, MARUNOUCHI T, KANNO T

Neuroscience Letters   237 巻 ( 1 ) 頁： 49-52   1997年11月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）