Faculty Profiles - SUZUKI, Hiromi

Papers - SUZUKI, Hiromi

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アルツハイマー病早期診断マーカーのための活性化ミクログリアの画像化-PETによる末梢性ベンゾジアゼピン受容体イメージング- Invited Reviewed

外山宏, 工藤元, 伊藤文隆, 片田和広, 大橋正男, 中根正人, 籏野健太郎, 加藤隆司, 伊藤健吾, 鈴木弘美, 澤田誠, 市瀬正則

医科学応用研究財団研究報告 26 page： 415 - 420 2007

The intra-arterial injection of microglia protects hippocampal CA1 neurons against global ischemia-induced functional deficits in rats Invited Reviewed

Y. Hayashi, Y. Tomimatsu, H. Suzuki, J. Yamada, Z. Wu, H. Yao, Y. Kagamiishi, N. Tateishi, M. Sawada, H. Nakanishi

NEUROSCIENCE Vol. 142 ( 1 ) page： 87 - 96 2006.9

Language：English Publishing type：Research paper (scientific journal) Publisher：PERGAMON-ELSEVIER SCIENCE LTD

In the present study, we have attempted to elucidate the effects of the intra-arterial injection of microglia on the global ischemia-induced functional and morphological deficits of hippocampal CA1 neurons. When PKH26-labeled immortalized microglial cells, GMIR1, were injected into the subclavian artery, these exogenous microglia were found to accumulate in the hippocampus at 24 h after ischemia. In hippocampal slices prepared from medium-injected rats subjected to ischemia 48 h earlier, synaptic dysfunctions including a significant reduction of synaptic responses and a marked reduction of long-term potentiation (LTP) of the CA3-CA1 Schaffer collateral synapses were observed. At this stage, however, neither significant neuronal degeneration nor gliosis was observed in the hippocampus. At 96 h after ischemia, there was a total loss of the synaptic activity and a marked neuronal death in the CA1 subfield. In contrast, the basal synaptic transmission and LTP of the CA3-CA1 synapses were well preserved after ischemia in the slices prepared from the microglia-injected animals. We also found the microglial-conditioned medium (MCM) to significantly increase the frequency of the spontaneous postsynaptic currents of CA1 neurons without affecting the amplitude, thus indicating that MCM increased the provability of the neurotransmitter release. The protective effect of the intra-arterial injected microglia against the ischemia-induced neuronal degeneration in the hippocampus was substantiated by immunohistochemical and immunoblot analyses. Furthermore, the arterial-injected microglia prevented the ischemia-induced decline of the brain-derived neurotrophic factor (BDNF) levels in CA1 neurons. These observations strongly suggest that the arterial-injection of microglia protected CA1 neurons against the ischemia-induced neuronal degeneration. The restoration of the ischemia-induced synaptic deficits and the resultant reduction of the BDNF levels in CA1 neurons, possibly by the release of diffusible factor(s), might thus contribute to the protective effect of the arterial-injection of microglia against ischemia-induced neuronal degeneration. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.neuroscience.2006.06.003

Web of Science

PubMed

The intra-arterial injection of microglia protects hippocampal CA1 neurons against global ischemia-induced functional deficits in rats

HAYASHI Y, TOMIMATSU Y, SUZUKI H, YAMADA J, WU Z, YAO H, KAGAMIISI Y, TAKEISHI N, SAWADA M, NAKANISHI H

Neuroscience Vol. 142 ( 1 ) page： 87-96 2006.9

Modulations of muscle protein metabolism by branched-chain amino acids in normal and muscle-atrophying rats. Invited Reviewed

Kobayashi H, Kato H, Hirabayashi Y, Murakami H, Suzuki H

The Journal of nutrition Vol. 136 ( 1 Suppl ) page： 234S - 6S 2006.1

Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with MPTP Invited Reviewed

Hirohide Sawada, Ryohei Hishida, Yoko Hirata, Kenji Ono, Hiromi Suzuki, Shin-ichi Muramatsu, Imaharu Nakano, Kunihiro Tsuchida, Toshiharu Nagatsu, Makoto Sawada

NEUROSCIENCE RESEARCH Vol. 55 page： S201 - S201 2006

In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand, [11C]PK11195 and animal PET following implantation of cultured activated microglia into rat striatum Invited Reviewed

Kudo, G; Toyama, H; Hatano, K; Suzuki, H; Ichise, M; Ito, F; Kato, T; Sawada, M; Katada, K; Ito, K

NEUROIMAGE Vol. 31 page： T148 - T148 2006

活性型ミクログリアの In Vivo イメージング Invited Reviewed

鈴木弘美, 外山宏, 工藤元, 籏野健太郎, 関亦克彦, 小野健治, 中根正人, 加藤隆司, 伊藤健吾, 澤田誠

バイオイメージング Vol. 14 ( 3 ) page： 129 - 130 2005.9

A lentiviral expression system demonstrates that L*protein of Theiler's murine encephalomyelitis virus(TMEV) is essential for virus growth in a murine macrophage-like cell line.

HIMEDA T, OHARA Y, ASAKURA K, KONTANI Y, MURAKAMI M, SUZUKI H, SAWADA M

Virus Research Vol. 108 ( 1-2 ) page： 23-28 2005.3

Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains.

IMAMURA K, HISHIKAWA N, ONO K,SUZUKI H, SAWADA M, NAGATSU T, YOSHIDA M, HASHIZUME Y

Acta Neuropathologica Vol. 109 ( 2 ) page： 141-150 2005.2

Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains Invited Reviewed

K Imamura, N Hishikawa, K Ono, H Suzuki, M Sawada, T Nagatsu, M Yoshida, Y Hashizume

ACTA NEUROPATHOLOGICA Vol. 109 ( 2 ) page： 141 - 150 2005.2

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

Dementia is a frequent complication of Parkinson's disease (PD) and usually occurs late in the protracted course of the illness. We have already reported numerous MHC class II-positive microglia in the hippocampus in PD patients, and that this phenomenon may be responsible for functional changes in the neurons and the cognitive decline in PD patients. In this study, we have investigated the distribution of activated microglia and the immunohistochemical and the mRNA expression of several cytokines and neurotrophic factors of the hippocampus in PD and dementia with Lewy bodies (DLB). The brains from five cases of PD and five cases of DLB that were clinically and neuropathologically diagnosed, and those from four normal controls (NC) were evaluated by immunohistochemistry using anti-HLA-DP, -DQ, -DR (CR3/43), anti-alpha-synuclein, anti-brain-derived neurotrophic factor (BDNF), and anti-glial fibrillary acidic protein antibodies. In addition, the mRNA expressions of cytokines (IL-1 alpha, IL-1 beta, TNF-alpha, IL-6, TGF-beta) and neurotrophic factors (BDNF, GDNF, NGF, NT-3) of these brains were evaluated by the reverse transcription-PCR method. MHC class II-positive microglia were distributed diffusely in the hippocampus of PD and DLB brains. Although the cytoplasm of pyramidal and granular cells of the hippocampus in NC brains was strongly stained by anti-BDNF antibodies, it was only weakly stained in PD and DLB brains. The mRNA expression of IL-6 was significantly increased in the hippocampus of PD and DLB brains, and that of BDNF was significantly decreased in the hippocampus of DLB brains. The increased number of activated microglia and the production of neurotrophic cytokines such as IL-6, together with the decreased expression of the neurotrophic factors of neurons in the hippocampus of PD and DLB brains, may be related to functional cellular changes associated with dementia.

DOI： 10.1007/s00401-004-0919-y

Web of Science

Murine lymph node-derived stromal cells effectively support survival but induce no activation/proliferation of peripheral resting T cells in vitro Invited Reviewed

Zhou YW, Aritake S, Endharti AT, Wu JH, Hayakawa A, Nakashima I, Suzuki H

IMMUNOLOGY Vol. 109 ( 4 ) page： 496 - 503 2003.8

Preservation of hematopoietic properties in transplanted bone marrow cells in the brain. Invited Reviewed

Ono K, Yoshihara K, Suzuki H, Tanaka KF, Takii T, Onozaki K, Sawada M

Journal of neuroscience research Vol. 72 ( 4 ) page： 503 - 7 2003.5

Existence of functional beta(1)- and beta(2)-adrenergic receptors on microglia

KF Tanaka, H Kashima, H Suzuki, K Ono, M Sawada

JOURNAL OF NEUROSCIENCE RESEARCH Vol. 70 ( 2 ) page： 232 - 237 2002.10

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-LISS

We examined the expression and function of beta-adrenergic receptor (beta-AR) subtypes in both isolated primary rat microglia and a rat microglial cell line. RTPCR analyses revealed that microglia expressed beta(1)- and beta(2)-ARs but not beta(3)-ARs, whereas rat primary peritoneal macrophages expressed only beta(2)-ARs. Stimulation of beta-ARs on microglia by norepinephrine (NE) resulted in an increase in the level of intracellular cAMP and the subsequent expression of interleukin-1beta mRNA. These effects were prevented by propranolol. Similar results were obtained with other selective beta(1)-AR agonists and antagonists. beta(2)-ARs on microglia were also functional. It is possible that noradrenergic innervations participate in the control of microglial functions via beta(1)-ARs on microglia in the brain, because NE has high affinity for beta(1)- and beta(3)-ARs but little or no affinity for beta(2)-ARs. It seems physiologically significant that microglia can be controlled by NE, which predominates over epinephrine in the brain, whereas macrophages in peripheral tissues can be controlled by epinephrine, which is at higher levels in peripheral tissues. (C) 2002 Wiley-Liss, inc.

DOI： 10.1002/jnr.10399

Web of Science

Modes of activation of mitogen-activated protein kinases and their roles in cepharanthine-induced apoptosis in human leukemia cells Invited Reviewed

Wu JH, Suzuki H, Akhand AA, Zhou YW, Hossain K, Nakashima I

CELLULAR SIGNALLING Vol. 14 ( 6 ) page： 509 - 515 2002.6

Brain-specific migration and protective roles in brain damage of microglia - A new therapeutic approach for catecholamine neuronal disfunctions Reviewed

M Sawada, F Imai, H Suzuki

CATECHOLAMINE RESEARCH: FROM MOLECULAR INSIGHTS TO CLINICAL MEDICINE Vol. 53 page： 217 - 220 2002

Preservation of neurotophin expression in microglia that migrate into the gerbil's brain across the blood-brain barrier.

SUZUKI H, IMAI F, KANNO T, SAWADA M

Neuroscience Letters Vol. 312 ( 2 ) page： 95-98 2001.10

Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation Invited Reviewed

Takeda K, Kato M, Wu JH, Iwashita T, Suzuki H, Takahashi M, Nakashima I

ANTIOXIDANTS & REDOX SIGNALING Vol. 3 ( 3 ) page： 473 - 482 2001.6

4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death. Invited Reviewed

Liu W, Kato M, Akhand AA, Hayakawa A, Suzuki H, Miyata T, Kurokawa K, Hotta Y, Ishikawa N, Nakashima I

Journal of cell science Vol. 113 ( Pt 4) page： 635 - 41 2000.2

Molecular Mechanism of Activation and Superactivation of Ret Tyrosine Kinases by Ultraviolet Light Irradiation Invited Reviewed

Kato Masashi, Iwashita Toshihide, Akhand Anwarul A., Liu Wei, Takeda Kozue, Takeuchi Kei, Yoshihara Motoi, Hossain Khaled, Wu Jianghong, Du Jun, Oh Chanho, Kawamoto Yoshiyuki, Suzuki Haruhiko, Takahashi Masahide, Nakashima Izumi

ANTIOXIDANTS & REDOX SIGNALING Vol. 2 ( 4 ) page： 841 - 850 2000

Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo Invited Reviewed

Suzuki H, Zhou YW, Kato M, Mak TW, Nakashima I

JOURNAL OF EXPERIMENTAL MEDICINE Vol. 190 ( 11 ) page： 1561 - 1571 1999.12

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Papers - SUZUKI, Hiromi