Papers - SAWADA, Makoto
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Calmodulin as a Key Regulator of Exosomal Signal Peptides Reviewed
Ono Kenji, Niwa Mikio, Suzuki Hiromi, Kobayashi Nahoko Bailey, Yoshida Tetsuhiko, Sawada Makoto
CELLS Vol. 12 ( 1 ) page: 158 2023.1
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Signal Sequence-Dependent Orientation of Signal Peptide Fragments to Exosomes. Reviewed International journal
International journal of molecular sciences Vol. 23 ( 6 ) 2022.3
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ミクログリアと情動制御 Invited Reviewed
生体の科学[増大特集:脳とからだ 2021.10
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Detection of Alzheimer's disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein Reviewed International coauthorship
Ji Bin, Ono Maiko, Yamasaki Tomoteru, Fujinaga Masayuki, Zhang Ming-Rong, Seki Chie, Aoki Ichio, Kito Seiji, Sawada Makoto, Suhara Tetsuya, Sahara Naruhiko, Higuchi Makoto
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM Vol. 41 ( 8 ) page: 2076 - 2089 2021.8
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Secretion of signal peptides via extracellular vesicles Reviewed
Ono Kenji, Niwa Mikio, Suzuki Hiromi, Kobayashi Nahoko Bailey, Yoshida Tetsuhiko, Sawada Makoto
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 560 page: 21 - 26 2021.6
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Silica Nanoparticle Induced Lung Injury in Mice: Dissecting Relative Contribution of Its Size and Surface Modification Reviewed
Inoue M., Sakamoto K., Suzuki A., Nakahara Y., Hashimoto N., Hasegawa Y., Sawada M.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 201 2020
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LC-MS/MS imaging with thermal film-based laser microdissection Reviewed
Oya Michiko, Suzuki Hiromi, Anas Andrea Roxanne J., Oishi Koichi, Ono Kenji, Yamaguchi Shun, Eguchi Megumi, Sawada Makoto
ANALYTICAL AND BIOANALYTICAL CHEMISTRY Vol. 410 ( 2 ) page: 491 - 499 2018.1
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The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model Reviewed
Yoshioka Naoki, Tanaka Miyako, Ochi Kozue, Watanabe Akiko, Ono Kenji, Sawada Makoto, Ogi Tomoo, Itoh Michiko, Ito Ayaka, Shiraki Yukihiro, Enomoto Atsushi, Ishigami Masatoshi, Fujishiro Mitsuhiro, Ogawa Yoshihiro, Suganami Takayoshi
BIOMEDICINE & PHARMACOTHERAPY Vol. 140 page: 111738 2021.8
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Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages Reviewed
Inoue Masahide, Sakamoto Koji, Suzuki Atsushi, Nakai Shinya, Ando Akira, Shiraki Yukihiko, Nakahara Yoshio, Omura Mika, Enomoto Atsushi, Nakase Ikuhiko, Sawada Makoto, Hashimoto Naozumi
PARTICLE AND FIBRE TOXICOLOGY Vol. 18 ( 1 ) page: 21 2021.6
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Peripheral benzodiazepine receptor/18 kDa translocator protein positron emission tomography imaging in a rat model of acute brain injury Reviewed International coauthorship
Nomura Masahiko, Toyama Hiroshi, Suzuki Hiromi, Yamada Takashi, Hatano Kentaro, Wilson Alan A., Ito Kengo, Sawada Makoto
ANNALS OF NUCLEAR MEDICINE Vol. 35 ( 1 ) page: 8 - 16 2021.1
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Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin Reviewed International coauthorship International journal
Wang Liyan, Li Mengjie, Lin Yinzhi, Du Shuwen, Liu Zhenyu, Ju Jianhua, Suzuki Hiromi, Sawada Makoto, Umezawa Kazuo
JOURNAL OF ANTIBIOTICS Vol. 73 ( 9 ) page: 622 - 629 2020.9
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Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects Reviewed
Kawakubo Mitsuhiro, Tanaka Miyako, Ochi Kozue, Watanabe Akiko, Saka-Tanaka Marie, Kanamori Yohei, Yoshioka Naoki, Yamashita Satoko, Goto Moritaka, Itoh Michiko, Shirakawa Ibuki, Kanai Sayaka, Suzuki Hiromi, Sawada Makoto, Ito Ayaka, Ishigami Masatoshi, Fujishiro Mitsuhiro, Arima Hiroshi, Ogawa Yoshihiro, Suganami Takayoshi
SCIENTIFIC REPORTS Vol. 10 ( 1 ) page: 983 2020.1
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Novel Oxindole-Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection Reviewed
Hirata Yoko, Ito Yuki, Takashima Madoka, Yagyu Kazuya, Oh-hashi Kentaro, Suzuki Hiromi, Ono Kenji, Furuta Kyoji, Sawada Makoto
ACS CHEMICAL NEUROSCIENCE Vol. 11 ( 1 ) page: 76 - 85 2020.1
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Role of Microglia in Neuroinflammation
Suzuki Hiromi, Sawada Makoto
PET/CT FOR INFLAMMATORY DISEASES: BASIC SCIENCES, TYPICAL CASES, AND REVIEW page: 30 - 34 2020
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A peptide based on transmembrane domain of S1PR4 as a tumor cell growth inhibitor
Yoshida Tetsuhiko, Tanaka Kenichi, Asakawa Shuichi, Sawada Makoto, Hasegawa Yoshinori, Nakase Ikuhiko, Kobayashi Nahoko Bailey
MOLECULAR CANCER THERAPEUTICS Vol. 18 ( 12 ) 2019.12
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Anti-claudin antibodies as a concept for development of claudin-directed drugs
Hashimoto Y, Okada Y, Shirakura K, Tachibana K, Sawada M, Yagi K, Doi T, Kondoh M
The Journal of pharmacology and experimental therapeutics Vol. 368 ( 2 ) page: 179 - 186 2019.2
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Selective autophagy eliminates ALS-related mutant SOD1 protein in cultured microglia
Niida Motoko Kawaguchi, Tsukahara Fujiko, Sudou Norihiro, Yamamoto Tomoko, Sawada Makoto, Watabe Kazuhiko, Shibata Noriyuki
BRAIN PATHOLOGY Vol. 29 page: 94 - 95 2019.2
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A peptide based on transmembrane domain of S1PR1 as a tumor cell growth inhibitor
Kobayashi N. Bailey, Sawada M., Hasegawa Y., Yoshida T.
EUROPEAN JOURNAL OF CANCER Vol. 103 page: E94 - E94 2018.11
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Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22 cells
Hirata Yoko, Yamada Chika, Ito Yuki, Yamamoto Shotaro, Nagase Haruna, Oh-hashi Kentaro, Kiuchi Kazutoshi, Suzuki Hiromi, Sawada Makoto, Furuta Kyoji
NEUROPHARMACOLOGY Vol. 135 page: 242 - 252 2018.6
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Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration.
Takatani Y, Ono K, Suzuki H, Inaba M, Sawada M, Matsuda N
Laboratory investigation; a journal of technical methods and pathology Vol. 98 ( 5 ) page: 629 - 639 2018.5
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Visualization of Arc promoter-driven neuronal activity by magnetic resonance imaging
Wu Qi, Ono Kenji, Suzuki Hiromi, Eguchi Megumi, Yamaguchi Shun, Sawada Makoto
NEUROSCIENCE LETTERS Vol. 666 page: 92-97 2018.2
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Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis
Lin Hsiaoyun, Muramatsu Rieko, Maedera Noriko, Tsunematsu Hiroto, Hamaguchi Machika, Koyama Yoshihisa, Kuroda Mariko, Ono Kenji, Sawada Makoto, Yamashita Toshihide
EBIOMEDICINE Vol. 27 page: 71-85 2018.1
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Optogenetic control of cell differentiation in channelrhodopsin-2-expressing OS3, a bipotential glial progenitor cell line
Ono K, Suzuki H, Yamamoto R, Sahashi H, Takido Y, Sawada M
Neurochemistry International Vol. 104 page: 49-63 2017.3
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The novel monoclonal antibody 9F5 reveals expression of a fragment of GPNMB/osteoactivin processed by furin-like protease(s) in a subpopulation of microglia in neonatal rat brain
Kawahara K, Hirata H, Ohbuchi K, Nishi K, Maeda A, Kuniyasu A, Yamada D, Maeda T, Tsuji A, Sawada M, Nakayama H
Vol. 64 ( 11 ) page: 1938-1961 2016.11
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Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages
Matsumoto T,Takahashi N, Kojima T, Yoshioka Y, Ishikawa J, Furukawa K, Ono K, Sawada M, Ishiguro N,Yamamoto A
Arthritis research & therapy Vol. 18 ( 1 ) page: 133 2016.6
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Nanoparticles speckled by ready-to-conjugate lanthanide complexes for multimodal imaging
Biju V, Hamada M, Ono K, Sugino S, Ohnishi T, Shibu ES, Yamamura S, Sawada M, Nakanishi S, Shigeri Y, Wakida SI.
Nanoscale Vol. 7 ( 36 ) page: 14829-14837 2015.9
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Insular neural system controls decision-making in healthy and methamphetamine-treated rats
Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Nakamura A, Wang T, Nagai T, Sato J, Sawada M, Ohira H, Yamanaka A, Yamada K
Proceedings of the National Academy of Sciences of the United States of America Vol. 112 ( 29 ) page: E3930-3939 2015.7
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Rapid trimming of cell surface polySia by exovesicular sialidase triggers release of preexisting surface neurotrophin
Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K, Sato C.
The Journal of Biological Chemistry Vol. 290 ( 21 ) page: 13202-13214 2015.5
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Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [ 11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [ 11C](R)-PK11195.
Hatano K, Sekimata K, Yamada T, Abe J, Ito K, Ogawa M, Magata Y, Toyohara J, Ishiwata K, Biggio G, Serra M, Laquintana V, Denora N, Latrofa A, Trapani G, Liso G, Suzuki H, Sawada M, Nomura M, Toyama H.
Ann Nucl Med Vol. 29 ( 4 ) page: 325-335 2015.5
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Nanoparticles speckled by ready-to-conjugate lanthanide complexes for multimodal imaging
Biju V, Hamada M, Ono K, Sugino S, Ohnishi T, Shibu ES, Yamamura S, Sawada M, Nakanishi S, Shigeri Y, Wakida SI.
Nanoscale page: in press 2015
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Insular neural system controls decision-making in healthy and methamphetamine-treated rats
Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Nakamura A, Wang T, Nagai T, Sato J, Sawada M, Ohira H, Yamanaka A, Yamada K
Proc. Natl. Acad. Sci. U.S.A page: in press 2015
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Novel positively charged nanoparticle labeling for in vivo imaging of adipose tissue-derived stem cells
YUKAWA H, NAKAGAWA S, YOSHIZUMI Y, WATANABE M, SAITO H, MIYAMOTO Y, NOGUCHI H, OISHI K, ONO K, SAWADA M, KATO I, ONOSHIMA D, OBAYASHI M, HAYASHI Y, KAJI N, ISHIKAWA T, HAYASHI S, BABA Y
PLoS One Vol. 9 ( 11 ) page: e110142 2014.11
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Protective effect of INI-0602, a gap junction inhibitor, on dopaminergic neurodegeneration of mice with unilateral 6-hydroxydopamine injection
SUZUKI Hiromi, ONO Kenji, SAWADA Makoto
Journal of nueral Transmission Vol. 121 ( 11 ) page: 1349-1355 2014.11
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Glutamate release from astrocyte cell-line GL261 via alterations in the intracellular ion environment Reviewed
ONO K, SUZUKI H, HIGA M, TABATA K, SAWADA M
Journal of Neural Transmission Vol. 121 ( 3 ) page: 245-257 2014.3
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Increases in intracellular pH facilitate endocytosis and decrease availability of voltage-gated proton channels in osteoclasts and microglia Reviewed
Sakai H, Li G, Hino Y, Moriura Y, Kawawaki J, Sawada M, Kuno M.
The Journal of Physiology Vol. 591 ( Pt23 ) page: 5851-5866 2013.12
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The effect of lipid emulsion on intracellular bupivacaine as a mechanism of lipid resuscitation: an electrophysiological study using voltage-gated proton channels Reviewed
HORI Kotaro, MATSUURA Tadashi, MORI Takashi, KUNO Miyuki, SAWADA Makoto, NISHIKAWA Kiyonobu
Anesthesia and analgesia Vol. 117 ( 6 ) page: 1293-1301 2013.12
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Photouncaging nanoparticles for MRI and fluorescence imaging in vitro and in vivo Reviewed
SHIBU Edakkattuparambil Sidharth, ONO Kenji, SUGINO Sakiko, NISHIOKA Ayami, YASUDA Akikazu, SHIGERI Yasushi, WAKIDA Shin-ichi, SAWADA Makoto, BIJU Vasudevanpillai
American Chemical Society nano Vol. 7 ( 11 ) page: 9851-9859 2013.11
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Singlet-Oxygen-Sensitizing Near-Infrared-Fluorescent Multimodal Nanoparticles Reviewed
Shibu ES, Sugino S, Ono K, Saito H, Nishioka A, Yamamura S, Sawada M, Nosaka Y, Biju V
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 52 ( 40 ) page: 10559-10563 2013.9
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In vivo imaging of transplanted islets labeled with a novel cationic nanoparticle Reviewed
OISHI Koichi, MIYAMOTO Yoshitaka, SAITO Hiroaki, MURASE Katsutoshi, ONO Kenji, SAWADA Makoto, WATANABE Masami, NOGUCHI Yasufumi, FUJIWARA Toshiyoshi, HAYASHI Shuji, NOGUCHI Hirofumi.
PLoS one Vol. 8 ( 2 ) page: e57046 2013.2
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Novel positive-charged nanoparticles for efficient magnetic resonance imaging of islet transplantation.
OISHI Kouichi, NOGUCHI Hirofumi, SAITO Hiroaki,YUKAWA H, MIYAMOTO Yoshitaka, ONO Kenji, MURASE Katsutoshi, SAWADA Makoto, HAYASHI Shuji
Cell Medicine Vol. 3 ( 1-3 ) page: 43-49 2012.10
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Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia Reviewed
Matsuura T, Mori T, Hasaka M, Kuno M, Kawawaki J, Nishikawa K, Narahashi T, Sawada M, Asada A
The Journal of Physiology Vol. 590 ( Pt4 ) page: 827-844 2012.2
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Hemokinin-1 gene expression is upregulated in microglia activated by lipopolysaccharide through NFkB and p38 MAPK signaling pathways
SAKAI Atsushi, TAKASU Kumiko, SAWADA Makoto, SUZUKI Hidenori
PLoS one Vol. 7 ( 2 ) page: e32268 2012.2
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New fluorescent probes targeting the mitochondrial-located translocator protein 18 kDa (TSPO) as activated microglia imaging agents. Reviewed
DENORA N, LAQUINTANA V, TRAPANI A, SUZUKI H, SAWADA M, TRAPANI G
Pharmaceutical Research Vol. 28 ( 11 ) page: 2820-2382 2011.11
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Alzheimer's disease and microglia
HIGUCHI M, JI B, MAEDA J, MARUYAMA M, ONO M, SAWADA M, SUHARA T
Rinsho Shinkeigaku Vol. 51 ( 11 ) page: 1031 2011.11
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Effects of a Brain-Engraftable Microglial Cell Line Expressing Anti-Prion scFv Antibodies on Survival Times of Mice Infected with Scrapie Prions Reviewed
FUJITA K, YAMAGUCHI Y, MORI T, MURAMATSU N, MIYAMOTO T, YANO M, MIYATA H, OOTSUYAMA A, SAWADA M, MATSUDA H, KAJI R, SAKAGUCHI S
Cellular and Molecular neurobioloy Vol. 31 ( 7 ) page: 999-1008 2011.10
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Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus. Reviewed
MIZOGUCHI H, NAKADE J, TACHIBANA M, IBI D, SOMEYA E, KOIKE H, KAMEI H, NABESHIMA T, ITOHARA S, TAKUMA K, SAWADA M, SATO J, YAMADA K
Journal of Neuroscience Vol. 31 ( 36 ) page: 12963-12971 2011.9
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4-hydroxy-2-nonenal upregulates and phosphorylates cytosolic phospholipase A (2) in cultured Ra2 microglial cells via MAPK pathways Reviewed
SHIBATA N, KATO Y, INOSE Y, HIROI A, YAMAMOTO T, MORIKAWA S, SAWADA M, KOBAYASHI M
Neuropathology Vol. 31 ( 2 ) page: 122-128 2011.4
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Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome. Reviewed
IWAMA S, SUGIMURA Y, SUZUKI H, SUZUKI H, MURASE T, OZAKI N, NAGASAKI H, ARIMA H, MURATA Y, SAWADA M, OISO Y
Glia Vol. 59 ( 3 ) page: 452-462 2011.3
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Effects of a Brain-Engraftable Microglial Cell Line Expressing Anti-Prion scFv Antibodies on Survival Times of Mice Infected with Scrapie Prions Reviewed
FUJITA K, YAMAGUCHI Y, MORI T, MURAMATSU N, MIYAMOTO T, YANO M, MIYATA H, OOTSUYAMA A, SAWADA M, MATSUDA H, KAJI R, SAKAGUCHI S
Cellular and Molecular neurobioloy page: in press 2011
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Electrosprayed Synthesis of Red-Blood-Cell-Like Particles with Dual Modality for Magnetic Resonance and Fluorescence Imaging. Reviewed
HAYASHI K, ONO K, SUZUKI H, SAWADA M, MORIYA M, SAKAMOTO W, YOGO T
Small Vol. 6 ( 21 ) page: 2384-2391 2010.11
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High-frequency, magnetic-field-responsive drug release from magnetic nanoparticle/organic hybrid based on hyperthermic effect.
HAYASHI K, ONO K, SUZUKI H, SAWADA M, MORIYA M, SAKAMOTO W, YOGO T
ACS applied materials & interfaces Vol. 2 ( 7 ) page: 1903-1911 2010.7
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One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reaction for magnetic hyperthermia and magnetic resonance imaging Reviewed
HAYASHI K, ONO K, SUZUKI H, SAWADA M, MORIYA M, SAKAMOTO W, YOGO T
Chemistry of Materials Vol. 22 ( 12 ) page: 3768-3772 2010.6
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Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells. Reviewed
Yukawa H, Kagami Y, Watanabe M, Oishi K, Miyamoto Y, Okamoto Y, Tokeshi M, Kaji N, Noguchi H, Ono K, Sawada M, Baba Y, Hamajima N, Hayashi S.
Biomaterials Vol. 31 ( 14 ) page: 4094-4103 2010.5
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Two activated stages of microglia and PET imaging of peripheral benzodiazepine receptors with [(11)C]PK11195 in rats Reviewed
ITO Fumitaka, TOYAMA Hiroshi, KUDO Gen, SUZUKI Hiromi, HATANO Kentaro, ICHISE Masanori, KATADA Kazujhiro, ITO Kengo, SAWADA Makoto
Annals of Nuclear Medecine Vol. 24 ( 3 ) page: 163-169 2010.4
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Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model. Reviewed
ONO K, SUZUKI H, SAWADA M
Neuroscience Letters Vol. 473 ( 2 ) page: 146-150 2010.4
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Neuroprotective and Neurotoxic Phenotypes of Activated Microglia in Neonatal Mice with Respective MPTP- and Ethanol-Induced Brain Injury. Reviewed
Sawada H, Suzuki H, Nagatsu T, Sawada M.
Neuro-degenerative Diseases Vol. 7 ( 1-3 ) page: 64-67 2010.2
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4-hydroxy-2-nonenal upregulates and phosphorylates cytosolic phospholipase A (2) in cultured Ra2 microglial cells via MAPK pathways Reviewed
SHIBATA N, KATO Y, INOSE Y, HIROI A, YAMAMOTO T, MORIKAWA S, SAWADA M, KOBAYASHI M
Neuropathology Vol. in press 2010
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Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia. Reviewed
SUZUKI H, SUGIMURA Y, IWAMA S, SUZUKI H, OZAKI N, NAGASAKI H, ARIMA H, SAWADA M, OISO Y.
Journal of the American Society of Nephrology Vol. 21 ( 12 ) page: 2090-2098 2010
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*Ferritin reporter used for gene expression imaging by magnetic resonance. Reviewed
ONO Kenji, FUMA Kazuya, TABATA Kaori, SAWADA Makoto
Biochemical and Biophysical Research Communications Vol. 388 ( 3 ) page: 589-594 2009.10
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Temperature dependence of proton permeation through a voltage-gated proton channel Reviewed
KUNO Miyuki, ANDO Hiroyuki , MORIHATA Hirokazu, SAKAI Hiromu, MORI Hiroyuki, SAWADA Makoto, OIKI Shigetoshi
The Journal of General Physiology Vol. 134 ( 3 ) page: 191-205 2009.9
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Interleukin-6 induces prostaglandin E2 synthesis in mouse astrocytes Reviewed
CHIKUMA T, YOSHIMOTO T, OHBA M, SAWADA M, KATO T, SAKAMOTO T, HIYAMA Y, HOJO H
Journal of Molecilar Neuroscience Vol. 39 ( 1-2 ) page: 175-184 2009.9
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Marked induction of inducible nitric oxide synthase and tumor necrosis factor-alpha in rat CD40(+) microglia by comparison to CD40(-) microglia.
KAWAHARA K, YOSHIDA A, KOGA K, YOKOO S,KUNIYASU A, GOTOH T, SAWADA M, NAKAYAMA H
Journal of Neuroimmunology Vol. 208 ( 1-2 ) page: 70-79 2009.3
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Transforming growth factor-beta 1 upregulates keratan sulfate and chondroitin sulfate biosynthesis in microglias after brain injury Reviewed
YIN Jiarong, SAKAMOTO Kazuma, ZHANG Haoqian, ITO Zenya, IMAGAMA Shiro, KISHIDA Satoshi, NATORI Takamitsu, SAWADA Makoto, MATSUYAMA Yukihiro, KADOMATSU Kenji
Brain Research Vol. 1263 page: 10-22 2009.3
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Neuroprotective and toxic changes in microglia in neurodegenerative disease Reviewed
SAWADA Makoto
Parkinsonism & Related Disorders Vol. 15 page: S39-S41 2009.1
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L-dopa therapy for Parkinson's disease: Past, present, and future Reviewed
NAGATSU T, SAWADA M
Parkinsonism & Related Disorders Vol. 15 page: S3-S8 2009.1
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A link between stress and depression: Shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression Reviewed
MIURA H, OZAKI N, SAWADA M, ISOBE K, OHTA T, NAGATSU T
Stress-The International Journal on the Biology of Stress) Vol. 12 ( 5 ) page: 198-209 2009
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Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state Reviewed
MATSUMURA T, SAKAI A, NAGANO M, SAWADA M, SUZUKI H, UMINO M, SUZUKI H
Brit J Pharmacol Vol. 155 ( 5 ) page: 767-774 2008.11
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Blockade of microglial glutamate release protects against ischemic brain injury Reviewed
TAKEUCHI H,SHIJIE J, SUZUKI H, DOI Y, J. Liang, KAWANOKUCHI J, MIZUNO T, SAWADA M, SUZUMUTRA A
Exp Neurol Vol. 214 ( 1 ) page: 144-146 2008.11
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*Imaging of Peripheral Benzodiazepine Receptor Expression as Biomarkers of Detrimental versus Beneficial Glial Responses in Mouse Models of Alzheimer's and Other CNS Pathologies. Reviewed
Ji B, MAEDA J, SAWADA M, ONO M, OKAUCHI T, INAJI M, Zhang MR, SUZUKI K, ANDO K, Staufenbiel M, Trojanowski JQ, Lee VM, HIGUCHI M, SUHARA T
J Neurosci Vol. 28 ( 47 ) page: 12255-12267 2008.11
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Interleukin-4induced Selective Clearance of Oligomeric b-Amyloid peptide by Rat Primary Type-2 Microglia Reviewed
SHIMIZU E, KAWAHARA K , KAJIZONO M, SAWADA M, NAKAYAMA H
J Immunol Vol. 181 ( 9 ) page: 6503-6513 2008.11
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In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand: [(11)C]PK-11195 and animal PET following ethanol injury in rat striatum Reviewed
TOYAMA H, HATANO K, SUZUKI H, ICHISE M, MOMOSAKI S, KUDO G, ITO F, KATO T, YAMAGUCHI H, KATADA K, SAWADA M, ITO K
Ann Nucl Med Vol. 22 ( 5 ) page: 417-424 2008.6
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A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. Reviewed
MIURA H, OZAKI N, SAWADA M, ISOBE K, OHTA T, NAGATSU T
Stress-The International Journal on the Biology of Stress Vol. 11 ( 3 ) page: 198-209 2008.5
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Effects of aging on neuroprotective and neurotoxic properties of microglia in neurodegenerative diseases. Reviewed
SAWADA Makoto, SAWADA Hirohide, NAGATSU Toshiharu
Neurodegener Dis Vol. 5 ( 3-4 ) page: 254-256 2008.3
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Stimulus dependent regulation of the phagocyte NADPH oxidase by a VAV1, rac 1, and PAK1 signaling axis. Reviewed
ROEPSTORFF Kirstine, RASMUSSEN Izabela, SAWADA Makoto, CUDRE-MAROUX Cristophe, SALOMON Patrick, BOKOCH Gary, VAN DEURS Bo, VIHARDT Frederik
J Biol Chem Vol. 283 ( 12 ) page: 7983-7993 2008.3
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Early and late activation of the voltage-gated proton channel during lactic acidosis through pH-dependent and -independent mechanisms Reviewed
MORIHATA Hirokazu, KAWAWAKI Junko, OKINA Masako, SAKAI Hiromu, NOTOMI Takuya, SAWADA Makoto, KUNO Miyuki
Pflugers Arch Vol. 455 ( 5 ) page: 829-838 2008.2
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N-Benzyl-2-(6,8-dichloro-2-(-(4-chlorophenyl)imidazo[1,2-alpyridin-3-yl)-N-(6-(7-nitrobenzo[c][1,2,5]oxadiazol-4-ylamino) hexyl)acetamide as a New Fluorescent Probe for Peripheral Benzodiazepine Receptor and Microglial Cell Visualization. Reviewed
LAQUINTANA Valentino, DENORA Nunzio, LOPEDOTA Angela, SUZUKI Hiromi, SAWADA Makoto, SERRA Mariangela, BIGGIO Giovanni, LATROFA Andrea, TRAPANI Giuseppe, LISO Gaetano
Bioconjug Chem Vol. 18 ( 5 ) page: 1397-1407 2007.9
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Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide Reviewed
Hashioka, S., Klegeris, A., Monji, A., Kato, T., Sawada, M., McGeer, P.L. and Kanba, S.
Vol. 206 ( 0 ) page: 33-42 2007.7
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Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Sawada, H., Hishida, R., Hirata, Y., Ono, K., Suzuki, H., Muramatsu, S., Nakano, I., Nagatsu, T. and Sawada, M.
J Neurosci Res Vol. 85 ( 8 ) page: 1752-1761 2007.6
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Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway Reviewed
Ito, S., Kimura, K., Haneda, M., Ishida, Y., Sawada, M. and Isobe, K.
Vol. 42 ( 6 ) page: 532-537 2007.6
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The effects of general anesthetics on P2X7 and P2Y receptors in a rat microglial cell line Reviewed
Nakanishi, M., Mori, T., Nishikawa, K., Sawada, M., Kuno, M. and Asada, A.
Anesth Analg Vol. 101 ( 5 ) page: 1136-1144 2007.5
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Identification of ligands binding specifically to inflammatory intestinal mucosa using phage display Reviewed
Takagi, T., Arisawa, T., Yamamoto, K., Hirata, I., Nakano, H. and Sawada, M
Clin Exp Pharmacol Physiol Vol. 34 ( 4 ) page: 286-289 2007.4
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Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation Reviewed
Hashioka, S., Han, Y.H., Fujii, S., Kato, T., Monji, A., Utsumi, H., Sawada, M., Nakanishi, H. and Kanba, S.
Free Radic Biol Med Vol. 42 ( 7 ) page: 945-954 2007.4
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*Neuroprotective effect of exogenous microglia in global brain ischemia Reviewed
IMAI Fumihiro, SUZUKI Hiromi, ODA Jumpei, NINOMIYA Takashi, ONO Kenji, SANO Hirotoshi, SAWADA Makoto
Journal of Cerebral Blood Flow & Metabolism Vol. 27 ( 3 ) page: 488-500 2007.3
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Targeting and imaging of brain-specific cell migration Invited
Vol. 65 ( 2 ) page: 213-218 2007.2
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Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia. Reviewed
HASHIOKA Sadayuki, HAN Youn-Hee, FUJII Shunsuke, KATO Takahiro, MONJI Akira, UTSUMI Hideo, SAWADA Makoto, NAKANISHI Hiroshi, KANBA Shigenobu
Neurochemistry International Vol. 50 ( 3 ) page: 499-506 2007.2
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Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects Reviewed
NAGATSU Toshiharu, SAWADA Makoto
J Neural Transm Suppl. Vol. 72 page: 113-120 2007
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Amyloid-beta peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via PI3K/Akt and/or ERK pathway. Reviewed
ITO Sachiko, SAWADA Makoto, HANEDA Masataka, ISHIDA Yoshi, ISOBE Ken-ichi
Neuroscience Research Vol. 56 ( 3 ) page: 294-299 2006.11
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Role of cytokines in inflammatory process in Parkinson's disease Invited Reviewed
SAWADA Makoto, IMAMURA Kazuhiro, NAGATSU Toshiharu
Journal of Neural Transmission Supplement Vol. 70 page: 373-381 2006.11
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Cell cycle-dependent regulation of kainate-induced inward currents in microglia. Reviewed
Yamada Jun, Sawada Makoto, Nakanishi Hiroshi
Biochemical and Biophysical Research Communications Vol. 349 ( 3 ) page: 913-919 2006.10
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The intra-arterial injection of microglia protects hippocampal CAI neurons against global ischemia-induced functional deficits in rats. Reviewed
HAYASHI Yoshinori, TOMIMATSU Yoshirou, SUZUKI Hiromi, YAMADA Jun, WU Ziqiang, YAO Hngping, KAGAMIISHI Yoshifumi, TATEISHI Narito, SAWADA Makoto, NAKANISHI Hiroshi
Neuroscience Vol. 142 ( 1 ) page: 87-96 2006.9
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*Cellular and Molecular Mechanisms of Parkinson's Disease: Neurotoxins, Causative Genens, and Inflammatory Cytokines. Invited Reviewed
NAGATSU Toshiharu, SAWADA Makoto
Cellular and Molecular Neurobiology Vol. 26 ( 4-6 ) page: 781-802 2006.7
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Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: possible implications of glial cells Invited Reviewed
Nagatsu, T. and Sawada, M.
J Neural Transm Suppl Vol. 71 page: 53-65 2006
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Tonic-clonic seizures induce division of neuronal progenitor cells with concomitant changes in expression of neurotrophic factors in the brain of pilocarpine-treated mice Reviewed
HAGIHARA Hideo, HARA Mizumi, TSUNEKAWA Kyoko, NAKAGAWA Yukinori, SAWADA Makoto, NAKANO Kiwako
Molecular Brain Research Vol. 139 ( 2 ) page: 258-266 2005
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A lentiviral expression system demonstrates that L* protein of Theiler's murine encephalomyelitis virus (TMEV) has an anti-apoptotic effect in a macrophage cell line Reviewed
HIMEDA Toshiki, OHARA Yoshiro, ASAKURA Kunihiko, KONTANI Yasuhide, SAWADA Makoto
Microb Pathogenesis Vol. 38 ( 5-6 ) page: 201-207 2005
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Localization of cyclooxygenase-2 induced following traumatic spinal cord injury Reviewed
ADACHI Kayo, Yimin Yu, SATAKE Kotaro, MATSUYAMA Yukihiro, ISHIGURO Naoki, SAWADA Makoto, HIRATA Yoko, KIUCHI Kazutoshi
Neuroscience Research Vol. 51 page: 73-80 2005
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Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains Reviewed
Imamura, K., Hishikawa, N., Ono, K., Suzuki, H., Sawada, M., Nagatsu, T., Yoshida, M., Hashizume, Y.
Acta Neuropathol Vol. 109 page: 141-150 2005
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Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells Reviewed
ITO Sachiko, SAWADA Makoto, HANEDA Masataka, FUJII S, OHHASHI Kentaro, KIUCHI Kazatoshi, TAKAHASHI Masahide, ISOBE Ken-ichi
FEBS Letters Vol. 579 page: 1995-2000 2005
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Peripheral injection of lipopolysaccharide enhances expression of inflammatory cytokines in murine locus coeruleus: possible role of increased norepinephrine turnover Reviewed
KANEKO YokoS, MORI Kenji, NAKASHIMA Akira, SAWADA Makoto, NAGATSU Ikuko, OTA Akira
Journal of Neurochemistry Vol. 94 ( 2 ) page: 393-404 2005
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Double-stranded RNA stimulates chemokine expression in microglia through vacuolar pH-dependent activation of intracellular signaling pathways Reviewed
NAKAMICHI Kazuo, SAIKI Megumi, SAWADA Makoto, TAKAYAMA-ITO Mutsuyo, YAMAMURO Yutaka, MORIMOTO Kinjiro, KURANE Ichiro
Journal of Neurochemistry Vol. 95 page: 273-283 2005
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A lentiviral expression system demonstrates that L* protein of Theiler's murine encephalomyelitis virus (TMEV) is essential for virus growth in a murine macrophage-like cell line Reviewed
HIMEDA Toshiki, OHARA Yoshiro, ASAKURA Kunihiko, KONTANI Yasuhide, MURAKAMI Manabu, SUZUKI Hiromi, SAWADA Makoto
Virus Research Vol. 108 page: 23-28 2005
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Inhibition of inflammatory cytokine secretion from mouse microglia cells by DHMEQ, an NF-kappaB inhibitor Reviewed
TAKATSUNA Hiroshi, MORITA Shigeru, NAGATSU Toshiharu, SAWADA Makoto, UMEZAWA Kazuo
Biomedecine & Pharmacotherapy Vol. 59 page: 318-322 2005
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Vitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis rats Reviewed
MORIYA Masayuki, NAKATSUJI Yuji, OKUNO Tatsusada, HAMASAKI Toshimitsu, SAWADA Makoto, SAKODA Saburo
Journal of Neuroimmunology Vol. 59 page: 318-322 2005
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Rabies virus-induced activation of MAPK and NF-kappaB signaling pathways regulates expression of CXC and CC chemokine ligands in microglia Reviewed
NAKAMICHI Kazuo, SAIKI Megumi, SAWADA Makoto, YAMAMURO Yutaka, MORIMOTO Kinjiro, KURANE Ichiro
Journal of Virology Vol. 79 page: 11801-11812 2005
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Inflammatory process in Parkinson's disease: role for cytokines Invited Reviewed
Nagatsu, T., Sawada, M.
Curr Pharm Res Vol. 11 page: 999-1016 2005
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Superoxide production at phagosomal cup/phagosome through betal protein kinase C during FcgammaR-mediated phagocytosis in microglia.
T.Ueyama, M.R.Lennartz, Y.Noda, T.Kobayashi, Y.Shirai, K.Rikitake, T.Yamasaki, S.Hayashi, N.Sakai, H.Seguchi, M.Sawada, H.Sumitomo and N.Saito
J. Immunol. Vol. 173 ( 7 ) page: 4582-4589 2004
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Pepstatin A induces extracellular acidification distinct from aspartic protease inhibition in microglial cell lines.
M.Okada, S.Irie, M.Sawada, R.Urae, A.Urae, N.Iwata, N.Ozaki, K.Akazawa andH.Nakanishi
Glia Vol. 43 ( 2 ) page: 167-174 2003
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Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains.
K.Imamura, N.Hishikawa, M.Sawada, T.Nagatsu, M.Yoshida,and Y.Hashizume
Acta Neuropathol(Berl) Vol. 106 ( 6 ) page: 518-526 2003
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Microglial cell cycle-associated proteins control microglial proliferation in vivo and in vitro and are regulated by GM-CSF and density-dependent inhibition.
K.Koguchi, Y.Nakatsuji, T.Okuno, M.Sawada and S.Sakoda
J. Neurosci Res Vol. 74 ( 6 ) page: 898-905 2003
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Preservation of hematopoietic properties in transplanted bone marrow cells in the brain.
K.Ono, K.Yoshihara, H.Suzuki, K.F.Tanaka, T.Takii, K.Onozaki and M.Sawada
J. Neurosci Res Vol. 72 ( 4 ) page: 503-507 2003
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The HIV-1 Nef protein and phagocyte NADPH oxidase activation.
F.Vilhardt, O.Plastre, M.Sawada, K.Suzuki, M.Wiznerowicz. E.Kiyokawa, D.Trono and K.H.Krause
J.Biol Chem Vol. 277 ( 44 ) page: 42136-42143 2002
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Distinct Cell death mechamisms by Theiler's murine encephalomyelitis virus (TMEV) infection in microglia and macrophage
Y.Ohara, T.Himeda, K.Asakura and M.Sawada
Netrosci Lett. Vol. 327 ( 1 ) page: 41-44 2002
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Existence of functional b1-and b2-adrenergic receptors on microglia
K.F.Tanaka, H.Kashima, H.Suzuki, K.Ono and M.Sawada
J Neurosci. Res. Vol. 70 ( 2 ) page: 232-237 2002
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Glial cell line-derived neurotrophic factor enhances survival of GM-CSF dependent rat GMIR1-microglial cells
K.Salimi, K.Moser, B.Zassler, M.Reindl, N.Embacher, C.Schermer, C.Weis, J.Marksteiner, M.Sawada and C. Humpel
Neurosci Res. Vol. 43 ( 3 ) page: 221-229 2002
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alpha-Synuclein forms a complex with transcription factor Elk-1
A.Iwata, S.Miura, I Kanazawa, M.Sawada and N.Nukina
J. Neurochem. Vol. 77 ( 1 ) page: 239-252 2001
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Preservation of neurotrophin expression in microglia that migrate into the gerbil's brain across the blood brain barrier
H.Suzuki, F.Imai, T.Kanno and M.Sawada
Neurosci. Lett. Vol. 312 ( 2 ) page: 95-98 2001
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ミクログリア 21世紀の神経免疫学展望
医学の歩み Vol. 別冊 page: 32-35 2001
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ミクログリアの脳保護作用と脳特異的薬物輸送
現代医学 Vol. 48 ( 3 ) page: 615-620 2001
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ミクログリア細胞を用いた脳疾患の治療戦略
神経研究の進歩 ( 45 ) page: 63-72 2001
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Activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification: a comparison with Alzheimer disease
K.Imamura, M.Sawada, N.Ozaki, H.Naito, N.Iwata, R.Ishsihara, T.Takeuchi and H.Shibayama
Alzheimer Dis. Assoc. Disord. Vol. 15 ( 1 ) page: 45-50 2001
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Age-dependent and tissue-specific CAG rereat instability occurs in mouse knock-in for a mutant Huntington's disease gene
H.Ishiguro, K.Yamada, H.Sawada, K.Nishii, N.Ichino, M.Sawada, Y.Kurosawa,N.Matsushita, K.Kobayashi, J.Goto,H.Hashida, N.Masuda, I.Kanazawa and T.Nagatsu
J. Neurosci. Res. Vol. 65 ( 4 ) page: 289-297 2001
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Histamine production by cultured microglial cells of the mouse
Y.Katoh, M.Niimi, Y.Yamamoto, T.Kawamura, T.Morimoto-Ishizuka, M.Sawada, H.Takemori and A.YamatodaniH.Takemori and A.Yamatodani
Neurosci. Lett. Vol. 305 ( 3 ) page: 181-184 2001
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Differentiated regulation of allo-antigen presentation by different types of murine microglial cell lines.
T.Kanzawa, M.Sawada, K.Kato, K.Yamamoto, H.Mori and R.Tanaka
J Neurosci Res Vol. 62 ( 3 ) page: 383-388 2000
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Impaired cytokine production by peripheral blood mononuclear cells and monocytes/macrophages in Parkinson's disease.
Y.Hasegawa, T.Inagaki, M.Sawada and A.Suzumura
Acta Neurol. Scand. Vol. 101 ( 3 ) page: 159-164 2000
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Increased soluble tumor necrosis factor receptor levels in the serum of elderly people
Y.Hasegawa, M.Sawada, N.Ozaki, T.Inagaki and A.Suzumura
Gelontology Vol. 46 ( 4 ) page: 185-188 2000
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Cell cycle regulation and apoptosis
Clin. Neurosci Vol. 18 page: 407-409 2000
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Distinctive regulation of antigen presentation by different type of murine microglial clones
J. Neurosci Res. Vol. 62 page: 383-388 2000
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Temporal fluctuations of voltage-gated proton currents in rat spinal microglia via pH-dependent and-independent mechanisms
H.Morihata, J.Kawasaki, H.Sakai, M.Sawada, T.Tsutada and M.Kuno
Neurosci. Res. Vol. 38 ( 3 ) page: 265-271 2000
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細胞周期とアポトーシス
Clin. Neurosci Vol. 18 page: 407-409 2000
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細胞を使って脳の疾患を治療する試み
治療 Vol. 82 page: 2200-2202 2000
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Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions
Neurosci Lett Vol. 272 page: 127-130 1999
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Brain cytokine network and microglia
Jpn. J. Neuropsychopharmacol. Vol. 19 page: 151-154 1999
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Apoptosis and Necrosis
Seibutusiryoubunnseki Vol. 22 page: 93-100 1999
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Serial analysis of gene expression in a microglial cell line
Glia Vol. 28 page: 265-71 1999
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Effects of phosphodiesterase inhibitors on cytokine production by microglia
Mult Scler Vol. 5 page: 126-133 1999
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Effects of vesnarinone on cytokine production and activation of murine microglia
Life Sci Vol. 64 page: 1197-1203 1999
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Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type (]G0003[) phosphodiesterase inhibitor in the CNS
Brain Res Vol. 837 page: 203-212 1999
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Interliukin-10 inhibits both production of cytokines and expression of cytokine receptors in microglia
J Neurochem Vol. 72 page: 1466-1471 1999
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Migration of exogenous immature hematopoietic cells into adult mouse brain parenchyma under GFP-expressing bone marrow
Biochem Biophys Res Commun Vol. 262 page: 610-614 1999
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Enhanced Fos expression in the hippocampus of El mice after short-term vestibular stimulation
Neurosci Lett Vol. 271 page: 105-108 1999
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ミクログリアの新規な性質と脳での役割-ミクログリアは脳で何をしているか
細胞工学 Vol. 18 page: 550-558 1999
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アポトーシスとネクローシス
生物試料分析 Vol. 22 page: 93-100 1999
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脳のサイトカインネットワークとミクログリアの脳での役割
日本神経精神薬理学雑誌 Vol. 19 page: 151-154 1999
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"Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells."
Neurosci. Lett. Vol. 244 page: 17-20 1998
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Pathophysiological significance of cytokine network in the brain
Japan Scienctific Societies Press page: 217-228 1998
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Appotosis and Microglia
Nippon Yakurigaku Zasshi Vol. 112 page: 15-19 1998
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Differentiation-specific mRNA expression of a mouse bibptential glial cell line
Neurosci. Lett Vol. 258 page: 21-24 1998
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Cytokines and Neural differentiation
Clinical Neuroscience Vol. 16 page: 406-408 1998
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Insulin-like growth factor-I analogue prevents apoptosis mediated through an interleukin-Ib converting enzyme(caspase-1)-like protease of cerebellar external tranular layer neurons : developmental stage-specific mechanisms of neuronal cell death.
Neuroscience Vol. 84 page: 89-100 1998
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Microglial NO induces delayed neuronal death following acute injury in the striatum
Eur J Neurosci Vol. 10 page: 1613-1620 1998
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Production of interleukin-12 and expression of its receptors by murine microglia.
Brain Research Vol. 787 page: 139-142 1998
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Brain-specific gene expression by immortalized microglial cell-mediated gene transfer in the mammalian brain.
FEBS Lett. Vol. 433 page: 37-40 1998
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ミクログリアとアポートシス
日本薬学雑誌 Vol. 112 page: 15-19 1998
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神経系の分化とサイトカイン
Clinical Neuroscience Vol. 16 page: 406-408 1998
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Changes in gene expression in mouse astrocytes during long-term. serial cultivation
Tissue Culture Research Communication Vol. 16 page: 129-135 1997
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Possible strategy of therapies against brain intractable diseases by brain-speciffic gene delivery technique with immortalized microglia
Nippon-Iji-Shinpo Vol. 3844 page: 28-30 1997
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Expression of Ly-6C on microglia in the developing and adult mouse brain.
Neurosci. Lett. Vol. 239 page: 17-20 1997
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Migration activity microglia and macrophages into rat brain.
Neurosci. Lett. Vol. 237 page: 49-52 1997
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Cytokine network in the brain
Tissue Culture Research Communication Vol. 42 ( 3 ) page: 504-511 1997
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ミクログリア細胞株を用いた脳疾患の治療の可能性
日本醫事新報 Vol. 3844 page: 28-30 1997
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脳のサイトカインネットワーク
蛋白質核酸酵素 Vol. 42 ( 3 ) page: 504-511 1997
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ER-MP抗原陽性ミクログリアの存在について
Journal of Neural Transmission Vol. 15 page: 221-227 1996
-
Expression pattern of messenger RNAs for prostanoid receptors in glial cell cultures
Brain Research Vol. 707 page: 282-287 1996
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Presence of ER-MP antigen positive microglia
Tissue Culture Research Communications Vol. 15 page: 221-227 1996
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Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulationg factor
Brain Research Vol. 713 page: 192-198 1996
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ミクログリアの発生と多様性
細胞 Vol. 27 ( 5 ) page: 193-198 1995
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cDNA cloning of a thromboxane A2 receptor from rat astrocytes
Biochimica et Biophysica Acta Vol. 1265 page: 220-223 1995
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Apoptosis-regulating factors which bind adenovirus E1A and E1B proteins
Tissue Culture Research Communication Vol. 13 ( 16 ) page: 1884-1889 1995
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Neoptenin in immunological reactions in cancer and in the brain-- Possible involuement of macrophage and microglia
Pteridnes Vol. 6 page: 190-193 1995
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Insulin prevents apoptosis of external granular layer neurons in rat cerebellar slice cultures
Neuroscience Letters Vol. 199 page: 37-40 1995
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Developmental origin and multi-functional subtypes of microglia
The Cell Vol. 27 ( 5 ) page: 193-198 1995
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Expression of glutamate transporters in cultured glial cells
Neuroscience Letters Vol. 188 page: 140-142 1995
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The bipotential glial progenitor cell line can develop into both oligodendrocytes and astrocytes in the mouse forebrain
Neuroscience Letters Vol. 188 ( 1 ) page: 1-4 1995
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Cytokine network in the central nervous system and its roles in growth and differentiation of glial and neuronal cells
International Journal of Developmental Neuroscience Vol. 13 ( 3・4 ) page: 253-264 1995
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Induction of functional interleukin-2 receptor in mouse microglia
Journal of Neurochemistry Vol. 64 page: 1973-1979 1995
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Programmed cell death of PC12 induced by adenovirus EIA
Nueroscience Letters Vol. 191 page: 173-176 1995
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アデノウイルスE1AとE1Bに結合するアポトーシス調節因子
実験医学 Vol. 13 ( 16 ) page: 1884-1889 1995
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Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression
Journal of Neuroimmunology Vol. 53 page: 209-218 1994
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Production of interleukin-10 by mouse glial cells in culture
Biochemical and Biophysical Research Communications Vol. 205 ( 3 ) page: 1907-1915 1994
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Induction of MHC class II antigen expression on murine microglia by interleukin-3
Journal of Neuroimmunology Vol. 55 page: 119-125 1994
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Expression of cytokines during glial differentiation
Brain Research Vol. 656 page: 141-146 1994
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Production of interleukin-5 by mouse astrocytes and microglia in culture.
Neuroscience Letters ( 155 ) page: 175-178 1993
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Brain vessels near muscle autografts are sites for entry of isogeneic macrophage into brain
Experimental Neurology Vol. 124 page: 219-230 1993
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Gene expression commonly observed in both immune and neruous system
"Annual Review of Immunology, 1993" page: 134-142 1993
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Effects of microglia-derived cytokines on astrocyte proliferation. (共著)
Restoractive Newology and Neuvoscience ( 5 ) page: 347-352 1993
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Transforming Growth Factor-β Suppresses Activation and Proliferation of Microglia in Vitro. (共著)
Journal of Immunology ( 151 ) page: 2150-2158 1993
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Expression of cytokine receptors in cultured neural and glial cells.
Neuroscience Letters ( 160 ) page: 131-134 1993
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Regulation of astrocyte proliferation by prostaglandin E2 and the α subtype of protein kinase C.
Brain Research ( 613 ) page: 67-73 1993
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免疫系と神経系に共通する遺伝子発現
Annual Review免疫1993 page: 134-142 1993
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TNF alpha induces IL-6 production by astrocytes but not by microglia.
Brain Research Vol. 583 ( 1 ) page: 296-299 1992
-
"A PCR method for the quantitative assessment of mRNA for laminin A, B1, and B2 chains(共著)"
Kidney International ( 42 ) page: 764-769 1992
-
Establishment of mouse oligodendrocyte/type-2 astrocyte lineage cell line by transfection with origin-defective Simian virus 40 DNA(共著)
Cell Structure and Function ( 17 ) page: 325-333 1992
-
Induction of cytokines in glial cells by trans activator of human T cell lymphotropic virus type I.
FEBS Letters Vol. 313 ( 1 ) page: 47-50 1992
-
Down regulation of CD4 expression in cultured microglia by immunosuppressants and lipopolysaccharide.
Biochemical and Biophysical Research Communications Vol. 189 ( 2 ) page: 869-876 1992
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培養ミクログリアの免疫組織学的検討
臨床神経学 Vol. 31 ( 2 ) page: 127-134 1991
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Functional and immunohistochemical studies of cultured rat microglia. (共著)
Clinical Neurology Vol. 31 ( 2 ) page: 127-134 1991
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NIHにおける相同組換えによるGene Targettingの現状
蛋白質核酸酵素 Vol. 35 ( 13 ) 1990
-
"Tyrosine hydroxylase, tryptophan hydroxylase, biopterin and neopterin in the brain of anorexia nervosa. (共著)"
Journal of Neural Transmission Vol. 80 page: 145-150 1990
-
Effects of colony stimulating factors on isolated microglia in vitro. (共著)
Journal of Neuroimmunology Vol. 30 ( 2-3 ) page: 111-120 1990
-
HTLV-I trans activator induces class I MHC antigen expression in glial cells.
Journal of Virology Vol. 64 ( 8 ) page: 4002-4006 1990
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Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C.
Brain Research Vol. 509 ( 1 ) page: 119-124 1990
-
Production of granulocyte/macrophage colony-stimulating factor by cultured astrocytes. (共著)
Biochemical and Biophysical Research Communications Vol. 169 ( 2 ) page: 719-724 1990
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Gene targeting at NIH
"Proteins, Nucleic Acids and Enzymes" Vol. 35 ( 13 ) 1990
-
Production of tumor necrosis factor-alpha by microglia and astrocytes in culture.
Brain Research Vol. 491 ( 2 ) page: 394-397 1989
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神経伝達物質についての最近のアプローチ
メディカル・イムノロジー Vol. 16 ( 1 ) 1988
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Tryptophan hydroxylase activity in brain slices.
International Journal of Biochemistry Vol. 20 ( 10 ) page: 1033-1038 1988
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Resent approach to neurotransmitters
Medical Immunology Vol. 16 ( 1 ) 1988
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ビオプテリンとネオプテリンの蛍光偏光測定
蛋白質・核酸・酵素 Vol. 31 1987
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Combined use of urinary pteridines measured by radioimmunoassays and polyamines as tumor markers. (共著)
Biogenic Amines Vol. 4/ ( 1 ) page: 433-443 1987
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A factor inducing differentiation of the human nonocytic cell line U-937 produced by 12-O-tetradecanoylpholbol 13-acetate-treated U-937. (共著)
Japanese Journal of Cancer Research Vol. 78 page: 219-222 1987
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"Tyrosine hydroxylase, tryptophan hydroxylase, biopterin and neopterin in postmortem brains from control and patients with Alzheimer-type dementia."
Journal of Neurochemistry Vol. 48 page: 760-764 1987
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"Effects of thyrotropin releasing hormone and its analogue, DN1417, on biopterin concentration and tryptophan hydroxylation in rat raphe slices."
Life Sciences Vol. 41 page: 2733-2737 1987
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Polarization fluoroimmunoassay of biopterin and neopterin(共著)
"Proteins, Nucleic Acids, and Enzymes" Vol. 31 1987
-
Stimulation of serotonin autoreceptor prevents the calcium-calmodulin-dependent increase of serotonin biosynthesis in rat raphe slices.
Journal of Neurochemistry Vol. 46 page: 963-967 1986
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A sensitive assay of GTP cyclohydrolase I activity in rat and human tissues using radioimmunoassay of neopterin.
Analytical Biochemistry Vol. 154 page: 361-366 1986
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Effects of adrenergic drugs on the activities of tryptophan hydroxylase in midbrain raphe slices of the rat.
Neurochemistry International Vol. 8 ( 3 ) page: 413-416 1986
-
(6R)-Tetra-hydrobiopterin increases the activity of tryptophan hydroxylase in rat raphe slices.
Journal of Neurochemistry Vol. 47 page: 1544-1547 1986
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Preparation and cofactor activity of(6S)-tetrahydrobiopterin. (共著)
Chemistry Express Vol. 1 ( 7 ) page: 403-406 1986
-
"Changes in activities of tryptophan hydroxylase and cyclic AMP-dependent and calcium-calmodulin-dependent protein kinases in raphe serotonergic neurons of 5,7-dihydroxytryptamine-treated rats."
Neurochemistry International Vol. 7 ( 5 ) page: 761-763 1985
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"Synthesis, localization and release of 5-hydroxytryptamine in neuroblastoma x glioma NG108-15 hybrid cells. (共著)"
Brain Research Vol. 361 ( 1 ) page: 77-90 1985
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Tryptophan hydroxylase activity in the brains of controls and parkinsonian patients.
Journal of Neural Transmission Vol. 62 page: 107-115 1985
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"Kinetic analysis of the inhibition of tryptophan hydroxylase, a pteridine=requiring monooxygenase, by oudenone and its derivatives."
Biogenic Amines Vol. 1 page: 121-178 1984
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Radioimmunoassay for neopterin in body fluid and tissues. (共著)
Analytical Biochemistry Vol. 141 page: 472-480 1984
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Elevated levels of polyamines and radioimmuoassayable 6-hydroxymethy1-pterin-like compound in urine from cancer patients. (共著)
Biogenic Amines Vol. 1 page: 51-62 1984
-
Polarization fluoroimmunoassay of biopterin and neopterin in human urine.
Clinica Chimica Acta Vol. 138 page: 275-282 1984
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Serotonin in neuroblastoma x glioma NG108-15 hybrid cells. (共著)
Neurochemistry International Vol. 5 ( 5 ) page: 589-601 1983
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Tryptophan hydroxlase system in brain tissue slices assayed by high-performance liquid chromatography. (共著)
Neurochemistry International Vol. 5 ( 5 ) page: 603-609 1983
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Demonstration of tryptophan 5-monooxygenase activity in human brain by high-performance liquid chromatography with fluorometric detection. (共著)
Biochemistry International Vol. 2 ( 3 ) page: 295-303 1981