日本学術振興会　特別研究員(DC2)

2001年4月 - 2002年3月

Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver.

Tochio T, Ueno Y, Kitaura Y, Shinohara M, Kadota Y, Minoda K, Shimomura Y, Osawa T

Foods (Basel, Switzerland)   8 巻 ( 2 )   2019年2月

Ca2+-dependent inhibition of branched-chain alpha-ketoacid dehydrogenase kinase by thiamine pyrophosphate

Noguchi Seisuke, Kondo Yusuke, Ito Rina, Katayama Takahiro, Kazama Shunsuke, Kadota Yoshihiro, Kitaura Yasuyuki, Harris Robert A., Shimomura Yoshiharu

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   504 巻 ( 4 ) 頁： 916-920   2018年10月

Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex

Weng Liang, Han Yi-Peng, Enomoto Atsushi, Kitaura Yasuyuki, Nagamori Shushi, Kanai Yoshikatsu, Asai Naoya, An Jian, Takagishi Maki, Asai Masato, Mii Shinji, Masuko Takashi, Shimomura Yoshiharu, Takahashi Masahide

PLOS BIOLOGY   16 巻 ( 3 ) 頁： e2005090   2018年3月

Branched-chain amino acids regulate type I tropocollagen and type III tropocollagen syntheses via modulation of mTOR in the skin.

Yamane T, Morioka Y, Kitaura Y, Iwatsuki K, Shimomura Y, Oishi Y.

Biosci Biotechnol Biochem.     頁： 1-5   2018年

Branched-chain amino acid (BCAA) supplementation enhances adaptability to exercise training of mice with a muscle-specific defect in the control of BCAA catabolism

Xu Minjun, Kitaura Yasuyuki, Shindo Daichi, Shimomura Yoshiharu

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   82 巻 ( 5 ) 頁： 896-899   2018年

Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism

Xu Minjun, Kitaura Yasuyuki, Ishikawa Takuya, Kadota Yoshihiro, Terai Chihaya, Shindo Daichi, Morioka Takashi, Ota Miki, Morishita Yukako, Ishihara Kengo, Shimomura Yoshiharu

PLOS ONE   12 巻 ( 7 ) 頁： e0180989   2017年7月

Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. 査読有り

Honda T, Ishigami M, Luo F, Lingyun M, Ishizu Y, Kuzuya T, Hayashi K, Nakano I, Ishikawa T, Feng GG, Katano Y, Kohama T, Kitaura Y, Shimomura Y, Goto H, Hirooka Y.

Metabolism   69 巻   頁： 177-187   2017年4月

Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice

Honda Takashi, Ishigami Masatoshi, Luo Fangqiong, Lingyun Ma, Ishizu Yoji, Kuzuya Teiji, Hayashi Kazuhiko, Nakano Isao, Ishikawa Tetsuya, Feng Guo-Gang, Katano Yoshiaki, Kohama Tomoya, Kitaura Yasuyuki, Shimomura Yoshiharu, Goto Hidemi, Hirooka Yoshiki

METABOLISM-CLINICAL AND EXPERIMENTAL   69 巻   頁： 177-187   2017年4月

Effects of 1-Kestose Feeding on Cecal Microbiota which Produce Lactate and Short-chain Fatty Acids and on Blood Components in Rats

Shimomura Yoshiharu, Tochio Takumi, Kitaura Yasuyuki, Takahashi Motoki, Endo Akihito

FASEB JOURNAL   31 巻   頁： .   2017年4月

Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition.

Ishikawa T, Kitaura Y, Kadota Y, Morishita Y, Ota M, Yamanaka F, Xu M, Ikawa M, Inoue N, Kawano F, Nakai N, Murakami T, Miura S, Hatazawa Y, Kamei Y, Shimomura Y.

Sci Rep.   7 巻   頁： 39825   2017年1月

BCAA FUNCTION AND INSULIN RESISTANCE FROM THE STUDIES USING GENETICALLY ENGINEERED MICE IN BCAA CATABOLISM

Kitaura Yasuyuki, Shimomura Yoshiharu

ANNALS OF NUTRITION AND METABOLISM   71 巻   頁： 140-140   2017年

An Alteration in the Cecal Microbiota Composition by Feeding of 1-Kestose Results in a Marked Increase in the Cecal Butyrate Content in Rats.

Takumi Tochio, Yasuyuki Kitaura, Saki Nakamura, Chie Sugawa, Motoki Takahashi, Akihito Endo, Yoshiharu Shimomura.

PLoS One.   11 巻 ( 11 ) 頁： e0166850   2016年11月

mTORC1 is involved in the regulation of branched-chain amino acid catabolism in mouse heart.

Zhen H, Kitaura Y, Kadota Y, Ishikawa T, Kondo Y, Xu M, Morishita Y, Ota M, Ito T, Shimomura Y.

FEBS Open Bio.   6 巻 ( 1 ) 頁： 43-9   2016年1月

Novel Physiological Functions of Branched-Chain Amino Acids

Shimomura Y, Kitaura Y, Kadota Y, Ishikawa T, Kondo Y, Xu M, Ota M, Morishita Y, Bariuan JV, Zhen H.

Journal of Nutritional Science and Vitaminology (Tokyo).   61 巻   頁： Suppl:S112-4   2015年11月

分岐鎖アミノ酸(BCAA)の新規生理機能～バイオテクノロジー研究による証明～

下村 吉治, 北浦 靖之

  122 巻   頁： 16-22   2015年8月

分岐鎖アミノ酸代謝とインスリン抵抗性

下村 吉治, 北浦 靖之, 門田　吉弘

外科と代謝・栄養   49 巻 ( 4 ) 頁： 177-182   2015年8月

Clinical, biochemical, and metabolic characterization of mild forms of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion.

Yamada K, Aiba K, Kitaura K, Kondo Y, Nomura N, Nakamura Y, Fukushi D, Murayama K, Shimomura Y, Pitt J, Yamaguchi S, Yokochi K, Wakamatsu N.

J Med Genet.   52 巻 ( 10 ) 頁： 691-698   2015年

PEGylated d-serine dehydratase as a d-serine reducing agent.

Ito T, Takada H, Isobe K, Suzuki M, Kitaura Y, Hemmi H, Matsuda T, Sasabe J, Yoshimura T.

J Pharm Biomed Anal.   S0731-7085 巻 ( 14 ) 頁： 00651-7   2015年

Regulation of the plasma amino acid profile by leucine via the system L amino acid transporter.

Zhen H, Nakamura K, Kitaura Y, Kadota Y, Ishikawa T, Kondo Y, Xu M, Shimomura Y.

Biosci Biotechnol Biochem.   79 巻 ( 12 ) 頁： 2057-2062   2015年

Octanoic acid promotes branched-chain amino acid catabolism via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats.

Kadota Y, Toyoda T, Hayashi-Kato M, Kitaura Y, Shimomura Y.

Metabolism   64 巻   頁： 1157-1164   2015年

Enhanced oleate uptake and lipotoxicity associated with laurate.

Kitaura Y, Inoue K, Kato N, Matsushita N, Shimomura Y.

FEBS Open Bio   5 巻   頁： 485-491   2015年

Effects of ingesting highly branched cyclic dextrin during endurance exercise on rating of perceived exertion and blood components associated with energy metabolism.

Furuyashiki T, Tanimoto H, Yokoyama Y, Kitaura Y, Kuriki T, Shimomura Y.

Biosci Biotechnol Biochem.   78 巻 ( 12 ) 頁： 2117-9   2014年

Patients with low muscle mass have characteristic microbiome with low potential for amino acid synthesis in chronic liver disease

Yamamoto Kenta, Ishizu Yoji, Honda Takashi, Ito Takanori, Imai Norihiro, Nakamura Masanao, Kawashima Hiroki, Kitaura Yasuyuki, Ishigami Masatoshi, Fujishiro Mitsuhiro

SCIENTIFIC REPORTS   12 巻 ( 1 ) 頁： 3674   2022年3月

Changes of integrins in glycolipid-modified melanoma-derived exosomes

Kaneko Kei, Ohmi Yuhsuke, Kambe Mariko, Li Qi, Yesmin Farhana, Yamamoto Satoko, Kitaura Yoko, Ito Takako, Bhuiyan Robiul H., Tajima Orie, Furukawa Koichi, Furukawa Keiko

CANCER SCIENCE   113 巻   頁： 1553 - 1553   2022年2月

Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity

Yoshida Naofumi, Yamashita Tomoya, Osone Tatsunori, Hosooka Tetsuya, Shinohara Masakazu, Kitahama Seiichi, Sasaki Kengo, Sasaki Daisuke, Yoneshiro Takeshi, Suzuki Tomohiro, Emoto Takuo, Saito Yoshihiro, Ozawa Genki, Hirota Yushi, Kitaura Yasuyuki, Shimomura Yoshiharu, Okamatsu-Ogura Yuko, Saito Masayuki, Kondo Akihiko, Kajimura Shingo, Inagaki Takeshi, Ogawa Wataru, Yamada Takuji, Hirata Ken-ichi

ISCIENCE   24 巻 ( 11 ) 頁： 103342   2021年11月

Branched-chain amino acids regulate hyaluronan synthesis and PPAR alpha expression in the skin

Yamane Takumi, Kitaura Yasuyuki, Iwatsuki Ken, Shimomura Yoshiharu, Oishi Yuichi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   85 巻 ( 11 ) 頁： 2292 - 2294   2021年11月

Supplementation of 1-Kestose Modulates the Gut Microbiota Composition to Ameliorate Glucose Metabolism in Obesity-Prone Hosts

Watanabe Ayako, Tochio Takumi, Kadota Yoshihiro, Takahashi Motoki, Kitaura Yasuyuki, Ishikawa Hirohito, Yasutake Takanori, Nakano Masahiro, Shinohara Hiroe, Kudo Toru, Nishimoto Yuichiro, Mizuguchi Yoshinori, Endo Akihito, Shimomura Yoshiharu

NUTRIENTS   13 巻 ( 9 )   2021年9月

1-Kestose supplementation mitigates the progressive deterioration of glucose metabolism in type 2 diabetes OLETF rats

Watanabe Ayako, Kadota Yoshihiro, Kamio Rina, Tochio Takumi, Endo Akihito, Shimomura Yoshiharu, Kitaura Yasuyuki

SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁： 15674   2020年9月

BDK Deficiency in Cerebral Cortex Neurons Causes Neurological Abnormalities and Affects Endurance Capacity

Mizusawa Anna, Watanabe Ayako, Yamada Minori, Kamei Rina, Shimomura Yoshiharu, Kitaura Yasuyuki

NUTRIENTS   12 巻 ( 8 )   2020年8月

Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure

Nakano Ippei, Hori Hiroaki, Fukushima Arata, Yokota Takashi, Kinugawa Shintaro, Takada Shingo, Yamanashi Katsuma, Obata Yoshikuni, Kitaura Yasuyuki, Kakutani Naoya, Abe Takahiro, Anzai Toshihisa

JOURNAL OF CARDIAC FAILURE   26 巻 ( 8 ) 頁： 685 - 693   2020年8月

Branched-chain amino acid supplementation ameliorates angiotensin II-induced skeletal muscle atrophy

Yamanashi Katsuma, Kinugawa Shintaro, Fukushima Arata, Kakutani Naoya, Takada Shingo, Obata Yoshikuni, Nakano Ippei, Yokota Takashi, Kitaura Yasuyuki, Shimomura Yoshiharu, Anzai Toshihisa

LIFE SCIENCES   250 巻   頁： 117593   2020年6月

Reply to Comment on Watanabe, A.; Kadota, Y.; Yokoyama, H.; Tsuruda, S.; Kamio, R.; Tochio, T.; Shimomura, Y.; Kitaura, Y. Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats. Foods 2020, 9, 4

Watanabe Ayako, Kadota Yoshihiro, Tochio Takumi, Shimomura Yoshiharu, Kitaura Yasuyuki

FOODS   9 巻 ( 4 )   2020年4月

Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats

Watanabe Ayako, Kadota Yoshihiro, Yokoyama Hijiri, Tsuruda Shunya, Kamio Rina, Tochio Takumi, Shimomura Yoshiharu, Kitaura Yasuyuki

FOODS   9 巻 ( 1 )   2020年1月

Effect of Genetically Decreased BCAA Concentration on Glucose Tolerance in Mice

Kitaura Yasuyuki, Senda Soushi, Shimomura Yoshiharu

ANNALS OF NUTRITION AND METABOLISM   75 巻   頁： 306 - 307   2019年

Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions

Shimomura Yoshiharu, Kitaura Yasuyuki

PHARMACOLOGICAL RESEARCH   133 巻   頁： 215 - 217   2018年7月

SPORTS NUTRITION FOR ACTIVE LIFE-STYLE

Shimomura Yoshiharu, Kitaura Yasuyuki

ANNALS OF NUTRITION AND METABOLISM   71 巻   頁： 1362 - 1362   2017年

PGC-1α-mediated branched-chain amino acid metabolism in the skeletal muscle.

Hatazawa Y, Tadaishi M, Nagaike Y, Morita A, Ogawa Y, Ezaki O, Takai-Igarashi T, Kitaura Y, Shimomura Y, Kamei Y, Miura S.

PLoS One   9 巻 ( 3 ) 頁： e91006   2014年

Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats

Mochizuki, M., Takayanagi, H., Yamada, S., Osawa, T., Kitaura, Y., Shimomura, Y.

J. Phys. Fitness Sports Med.   2 巻 ( 4 ) 頁： 509-513   2013年

Regulation of hepatic branched-chain α-ketoacid dehydrogenase complex in rats fed a high-fat diet

Kadota, Y., Toyoda, T., Kitaura, Y., Adams, S.H., Shimomura, Y.

Obesity Research & Clinical Practice   7 巻 ( 6 ) 頁： e439-e444   2013年

Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigens.

Chikazawa, M., Otaki, N., Shibata, T., Miyashita, H., Kawai, Y., Maruyama, S., Toyokuni, S., Kitaura, Y., Matsuda, T., Uchida, K.

J. Biol. Chem.   288 巻 ( 19 ) 頁： 13204-14   2013年

Clofibrate-Induced Reduction of Plasma Branched-Chain Amino Acid Concentrations Impairs Glucose Tolerance in Rats

Kadota, Y., Kazama, S., Bajotto, G., Kitaura, Y., Shimomura, Y.

JPEN J. Parenter. Enteral. Nutr.   36 巻   頁： 337-343   2012年

分岐鎖アミノ酸の生理機能の多様性

下村吉治、北浦靖之、門田吉弘

生化学   84 巻 ( 11 ) 頁： 8-12   2012年

Effects of protein and amino acid supplementation on muscle protein metabolism in relation to exercise.

Shimomura, Y., Kitaura, Y., and Shimomura, N.

J. Phys. Fitness Sports Med.   1 巻   頁： 219-225   2012年

Multiple factors and pathways involved in hepatic very low density lipoprotein-apoB100 overproduction in Otsuka Long-Evans Tokushima Fatty Rats. 査読有り

Qin, B., Anderson, R.A., Kuzuya, T., Kitaura, Y., and Shimomura, Y.

Atherosclerosis   222 巻   頁： 409-416   2012年

Effects of Branched-Chain Amino Acid Supplementation on Plasma Concentrations of Free Amino Acids, Insulin, and Energy Substrates in Young Men. 査読有り

J. Nutr. Sci. Vitaminol.   57 巻 ( 1 ) 頁： 114   2011年

Effect of branched-chain amino acid supplementation during unloading on regulatory components of protein synthesis in atrophied soleus muscles 査読有り

Bajotto G, Sato Y, Kitaura Y, Shimomura Y.

Eur. J. Appl. Physiol.   in press 巻   2011年

Branched-chain amino acids (BCAAs) as nutraceuticals for exercise

Shimomura, Y., Kitaura, Y., Sato, J.

Journal of Exercise Nutrition & Biochemistry   15 巻 ( 3 ) 頁： 115-118   2011年

Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease. 査読有り

Doisaki M, Katano Y, Nakano I, Hirooka Y, Itoh A, Ishigami M, Hayashi K, Goto H, Fujita Y, Kadota Y, Kitaura Y, Bajotto G, Kazama S, Tamura T, Tamura N, Feng GG, Ishikawa N, Shimomura Y.

Biochem. Biophys. Res. Commun.   393 巻 ( 2 ) 頁： 303   2010年

The mouse resources at the RIKEN BioResource center. 査読有り

Yoshiki, A., Ike, F., Mekada, K., Kitaura, Y., Nakata, H., Hiraiwa, N., Mochida, K., Ijuin, M., Kadota, M., Murakami, A., Ogura, A., Abe, K., Moriwaki, K., Obata, Y.

Exp. Anim.   58 巻   頁： 85-96   2009年

Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. 査読有り

Kitaura, Y., Jang, I.K., Wang, Y., Han, Y.C., Inazu, T., Cadera, E.J., Schlissel, M., Hardy, R.R., Gu, H.

Immunity   26 巻 ( 5 ) 頁： 567-578   2007年

Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins. 査読有り

Huang, F.*, Kitaura, Y.*, Jang, I., Naramura, M., Kole, H.H., Liu, L., Qin, H., Schlissel, M.S., Gu, H. (*These authors contributed equally to this work.)

Immunity   25 巻 ( 4 ) 頁： 571-581   2006年

PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. 査読有り

Pasqualucci, L., Kitaura, Y., Gu, H., Dalla-Favera, R.

Proc. Natl. Acad. Sci. U. S. A.   103 巻 ( 2 ) 頁： 395-400   2006年

The penta-EF-hand protein ALG-2 interacts with a region containing PxY repeats in Alix/AIP1, which is required for the subcellular punctate distribution of the amino-terminal truncation form of Alix/AIP1 招待有り 査読有り

Shibata H, Yamada K, Mizuno T, Yorikawa C, Takahashi H, Satoh H, Kitaura Y, Maki M

J Biochem   135 巻 ( 1 ) 頁： 117   2004年

Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions. 招待有り 査読有り

Kitaura Y, Satoh H, Takahashi H, Shibata H, Maki M

Arch Biochem Biophys. 399(1): 12-18   399 巻 ( 1 ) 頁： 12   2002年

ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca2+-dependent manner 査読有り

  291 巻 ( 5 ) 頁： 1166   2002年

Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner 査読有り

Kitaura Y, Matsumoto S, Satoh H, Hitomi K, Maki M

J Biol Chem   276 巻 ( 17 ) 頁： 14053   2001年

Peflin, a novel member of the five-EF-hand-protein family, is similar to the apoptosis-linked gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region 査読有り

Kitaura Y, Watanabe M, Satoh H, Kawai T, Hitomi K, Maki M

Biochem Biophys Res Commun   263 巻 ( 1 ) 頁： 68   1999年

Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. 査読有り

Takahashi C, Sheng Z, Horan TP, Kitayama H, Maki M, Hitomi K, Kitaura Y, Takai S, Sasahara RM, Horimoto A, Ikawa Y, Ratzkin BJ, Arakawa T, Noda M

Proc Natl Acad Sci U S A.   95 巻 ( 22 ) 頁： 13221   1998年

Calcium-induced exposure of a hydrophobic surface of mouse ALG-2, which is a member of the penta-EF-hand protein family. 査読有り

Maki M, Yamaguchi K, Kitaura Y, Satoh H, Hitomi K

Biochem Biophys Res Commun   124 巻 ( 6 ) 頁： 1170   1998年

心機能維持におけるアミノ酸栄養の重要性

研究課題/研究課題番号：16K14924  2016年4月 - 2018年3月

科学研究費助成事業  挑戦的萌芽研究

北浦 靖之, 下村 吉治

哺乳動物における生体調節因子としての分岐鎖アミノ酸の生理機能

2014年4月 - 2018年3月

科学研究費補助金  基盤研究(B)

下村　吉治

脂肪酸の組み合せによる脂肪毒性誘導メカニズムの解明

2013年4月 - 2016年3月

科学研究費補助金  基盤研究(C)

情報リテラシー

2018

基礎セミナー

2018

Agricultural science

2018

応用生命科学実験実習

2018

Agricultural science

2017

応用生命科学実験実習

2017

Agricultural science

2016

応用生命科学実験実習

2016

Agricultural science

2015

応用生命科学実験実習

2015

応用生命科学実験実習

2014

応用生命科学実験実習

2013

応用生命科学実験実習

2012

情報リテラシー

2011

応用生命科学実験実習

2011

応用生命科学実験実習

2010

応用生命科学実験実習

2009