Updated on 2022/04/27

写真a

 
KITAURA, Yasuyuki
 
Organization
Graduate School of Bioagricultural Sciences Lecturer
Graduate School
Graduate School of Bioagricultural Sciences
Undergraduate School
School of Agricultural Sciences Department of Applied Biosciences
Title
Lecturer

Degree 1

  1. 博士(農学) ( 2002.3   名古屋大学 ) 

Research Interests 7

  1. 運動

  2. インスリン抵抗性

  3. 代謝

  4. アミノ酸

  5. 栄養生化学

  6. 腸内細菌

  7. 肥満

Research Areas 2

  1. Life Science / Food sciences

  2. Life Science / Nutrition science and health science

Current Research Project and SDGs 3

  1. アミノ酸代謝とその生理機能

  2. 脂肪酸による細胞死誘導

  3. フラクトオリゴ糖の生理作用

Research History 6

  1. 名古屋大学大学院生命農学研究科 講師

    2017.4

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    Country:Japan

  2. 名古屋大学大学院生命農学研究科 助教

    2009.4 - 2017.3

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    Country:Japan

  3. Research Scientist, RIKEN BioResource Center

    2006.3 - 2009.3

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    Country:Japan

  4. Postdoctoral Research Scientist, Columbia University

    2003.4 - 2006.2

  5. Research Fellow (PD), Japan Society for the Promotion of Science

    2002.4 - 2003.3

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    Country:Japan

  6. Research Fellow (DC2), Japan Society for the Promotion of Science

    2001.4 - 2002.3

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    Country:Japan

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Education 1

  1. Nagoya University   Graduate School of Bioagricultural Sciences

    - 2002.3

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    Country: Japan

Professional Memberships 3

  1. 日本農芸化学会

  2. The Japanese Society for Amino Acid Sciences

  3. Japanese Society of Nutrition and Food Science

Awards 2

  1. 技術賞

    2019.5   日本栄養・食糧学会   ケストースの多様な生理機能の解明と実用化

    栃尾巧、門田吉弘、北浦靖之、遠藤明仁

  2. JAAAS Science and Technology Award

    2017.9  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 63

  1. BDK knockout skeletal muscle satellite cells exhibit enhanced protein translation initiation signal in response to BCAA in vitro

    Nakai Naoya, Iida Noriko, Kitai Saki, Shimomura Yoshiharu, Kitaura Yasuyuki, Higashida Kazuhiko

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 86 ( 5 ) page: 610 - 617   2022.2

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  2. Macrophages rely on extracellular serine to suppress aberrant cytokine production

    Kurita Kento, Ohta Hiroya, Shirakawa Ibuki, Tanaka Miyako, Kitaura Yasuyuki, Iwasaki Yorihiro, Matsuzaka Takashi, Shimano Hitoshi, Aoe Seiichiro, Arima Hiroshi, Ogawa Yoshihiro, Ito Ayaka, Suganami Takayoshi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 11137   2021.5

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  3. Urinary l-erythro-β-hydroxyasparagine-a novel serine racemase inhibitor and substrate of the Zn2+-dependent d-serine dehydratase.

    Ito T, Tono M, Kitaura Y, Hemmi H, Yoshimura T

    Bioscience reports   Vol. 41 ( 4 )   2021.4

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    DOI: 10.1042/BSR20210260

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  4. Magnesium depletion extends fission yeast lifespan via general amino acid control activation

    Ohtsuka Hokuto, Kobayashi Mikuto, Shimasaki Takafumi, Sato Teppei, Akanuma Genki, Kitaura Yasuyuki, Otsubo Yoko, Yamashita Akira, Aiba Hirofumi

    MICROBIOLOGYOPEN   Vol. 10 ( 2 ) page: e1176   2021.3

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  5. Antihypertensive drug valsartan as a novel BDK inhibitor.

    Kitaura Y, Shindo D, Ogawa T, Sato A, Shimomura Y

    Pharmacological research   Vol. 167   page: 105518   2021.2

  6. Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver.

    Tochio T, Ueno Y, Kitaura Y, Shinohara M, Kadota Y, Minoda K, Shimomura Y, Osawa T

    Foods (Basel, Switzerland)   Vol. 8 ( 2 )   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/foods8020069

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  7. Ca2+-dependent inhibition of branched-chain alpha-ketoacid dehydrogenase kinase by thiamine pyrophosphate

    Noguchi Seisuke, Kondo Yusuke, Ito Rina, Katayama Takahiro, Kazama Shunsuke, Kadota Yoshihiro, Kitaura Yasuyuki, Harris Robert A., Shimomura Yoshiharu

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 504 ( 4 ) page: 916-920   2018.10

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    DOI: 10.1016/j.bbrc.2018.09.038

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  8. Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex

    Weng Liang, Han Yi-Peng, Enomoto Atsushi, Kitaura Yasuyuki, Nagamori Shushi, Kanai Yoshikatsu, Asai Naoya, An Jian, Takagishi Maki, Asai Masato, Mii Shinji, Masuko Takashi, Shimomura Yoshiharu, Takahashi Masahide

    PLOS BIOLOGY   Vol. 16 ( 3 ) page: e2005090   2018.3

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    DOI: 10.1371/journal.pbio.2005090

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  9. Branched-chain amino acids regulate type I tropocollagen and type III tropocollagen syntheses via modulation of mTOR in the skin.

    Yamane T, Morioka Y, Kitaura Y, Iwatsuki K, Shimomura Y, Oishi Y.

    Biosci Biotechnol Biochem.     page: 1-5   2018

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  10. Branched-chain amino acid (BCAA) supplementation enhances adaptability to exercise training of mice with a muscle-specific defect in the control of BCAA catabolism

    Xu Minjun, Kitaura Yasuyuki, Shindo Daichi, Shimomura Yoshiharu

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 82 ( 5 ) page: 896-899   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/09168451.2018.1440174

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  11. Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism

    Xu Minjun, Kitaura Yasuyuki, Ishikawa Takuya, Kadota Yoshihiro, Terai Chihaya, Shindo Daichi, Morioka Takashi, Ota Miki, Morishita Yukako, Ishihara Kengo, Shimomura Yoshiharu

    PLOS ONE   Vol. 12 ( 7 ) page: e0180989   2017.7

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    DOI: 10.1371/journal.pone.0180989

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  12. Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. Reviewed

    Honda T, Ishigami M, Luo F, Lingyun M, Ishizu Y, Kuzuya T, Hayashi K, Nakano I, Ishikawa T, Feng GG, Katano Y, Kohama T, Kitaura Y, Shimomura Y, Goto H, Hirooka Y.

    Metabolism   Vol. 69   page: 177-187   2017.4

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  13. Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice

    Honda Takashi, Ishigami Masatoshi, Luo Fangqiong, Lingyun Ma, Ishizu Yoji, Kuzuya Teiji, Hayashi Kazuhiko, Nakano Isao, Ishikawa Tetsuya, Feng Guo-Gang, Katano Yoshiaki, Kohama Tomoya, Kitaura Yasuyuki, Shimomura Yoshiharu, Goto Hidemi, Hirooka Yoshiki

    METABOLISM-CLINICAL AND EXPERIMENTAL   Vol. 69   page: 177-187   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.metabol.2016.12.013

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  14. Effects of 1-Kestose Feeding on Cecal Microbiota which Produce Lactate and Short-chain Fatty Acids and on Blood Components in Rats

    Shimomura Yoshiharu, Tochio Takumi, Kitaura Yasuyuki, Takahashi Motoki, Endo Akihito

    FASEB JOURNAL   Vol. 31   page: .   2017.4

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    Web of Science

  15. Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition.

    Ishikawa T, Kitaura Y, Kadota Y, Morishita Y, Ota M, Yamanaka F, Xu M, Ikawa M, Inoue N, Kawano F, Nakai N, Murakami T, Miura S, Hatazawa Y, Kamei Y, Shimomura Y.

    Sci Rep.   Vol. 7   page: 39825   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep39825

  16. BCAA FUNCTION AND INSULIN RESISTANCE FROM THE STUDIES USING GENETICALLY ENGINEERED MICE IN BCAA CATABOLISM

    Kitaura Yasuyuki, Shimomura Yoshiharu

    ANNALS OF NUTRITION AND METABOLISM   Vol. 71   page: 140-140   2017

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  17. An Alteration in the Cecal Microbiota Composition by Feeding of 1-Kestose Results in a Marked Increase in the Cecal Butyrate Content in Rats.

    Takumi Tochio, Yasuyuki Kitaura, Saki Nakamura, Chie Sugawa, Motoki Takahashi, Akihito Endo, Yoshiharu Shimomura.

    PLoS One.   Vol. 11 ( 11 ) page: e0166850   2016.11

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    DOI: 10.1371/journal.pone.0166850

  18. mTORC1 is involved in the regulation of branched-chain amino acid catabolism in mouse heart.

    Zhen H, Kitaura Y, Kadota Y, Ishikawa T, Kondo Y, Xu M, Morishita Y, Ota M, Ito T, Shimomura Y.

    FEBS Open Bio.   Vol. 6 ( 1 ) page: 43-9   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/2211-5463.12007

  19. Novel Physiological Functions of Branched-Chain Amino Acids

    Shimomura Y, Kitaura Y, Kadota Y, Ishikawa T, Kondo Y, Xu M, Ota M, Morishita Y, Bariuan JV, Zhen H.

    Journal of Nutritional Science and Vitaminology (Tokyo).   Vol. 61   page: Suppl:S112-4   2015.11

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    DOI: 10.3177/jnsv.61.S112

  20. 分岐鎖アミノ酸(BCAA)の新規生理機能~バイオテクノロジー研究による証明~

    下村 吉治, 北浦 靖之

      Vol. 122   page: 16-22   2015.8

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  21. 分岐鎖アミノ酸代謝とインスリン抵抗性

    下村 吉治, 北浦 靖之, 門田 吉弘

    外科と代謝・栄養   Vol. 49 ( 4 ) page: 177-182   2015.8

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  22. Clinical, biochemical, and metabolic characterization of mild forms of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion.

    Yamada K, Aiba K, Kitaura K, Kondo Y, Nomura N, Nakamura Y, Fukushi D, Murayama K, Shimomura Y, Pitt J, Yamaguchi S, Yokochi K, Wakamatsu N.

    J Med Genet.   Vol. 52 ( 10 ) page: 691-698   2015

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    DOI: 10.1136/jmedgenet-2015-103231

  23. PEGylated d-serine dehydratase as a d-serine reducing agent.

    Ito T, Takada H, Isobe K, Suzuki M, Kitaura Y, Hemmi H, Matsuda T, Sasabe J, Yoshimura T.

    J Pharm Biomed Anal.   Vol. S0731-7085 ( 14 ) page: 00651-7   2015

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  24. Regulation of the plasma amino acid profile by leucine via the system L amino acid transporter.

    Zhen H, Nakamura K, Kitaura Y, Kadota Y, Ishikawa T, Kondo Y, Xu M, Shimomura Y.

    Biosci Biotechnol Biochem.   Vol. 79 ( 12 ) page: 2057-2062   2015

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    DOI: 10.1080/09168451.2015.1060845

  25. Octanoic acid promotes branched-chain amino acid catabolism via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats.

    Kadota Y, Toyoda T, Hayashi-Kato M, Kitaura Y, Shimomura Y.

    Metabolism   Vol. 64   page: 1157-1164   2015

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    DOI: 10.1016/j.metabol.2015.05.014

  26. Enhanced oleate uptake and lipotoxicity associated with laurate.

    Kitaura Y, Inoue K, Kato N, Matsushita N, Shimomura Y.

    FEBS Open Bio   Vol. 5   page: 485-491   2015

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    DOI: 10.1016/j.fob.2015.05.008

  27. Effects of ingesting highly branched cyclic dextrin during endurance exercise on rating of perceived exertion and blood components associated with energy metabolism.

    Furuyashiki T, Tanimoto H, Yokoyama Y, Kitaura Y, Kuriki T, Shimomura Y.

    Biosci Biotechnol Biochem.   Vol. 78 ( 12 ) page: 2117-9   2014

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    DOI: 10.1080/09168451.2014.943654

  28. Patients with low muscle mass have characteristic microbiome with low potential for amino acid synthesis in chronic liver disease.

    Yamamoto K, Ishizu Y, Honda T, Ito T, Imai N, Nakamura M, Kawashima H, Kitaura Y, Ishigami M, Fujishiro M

    Scientific reports   Vol. 12 ( 1 ) page: 3674   2022.3

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    DOI: 10.1038/s41598-022-07810-3

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  29. Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity

    Yoshida Naofumi, Yamashita Tomoya, Osone Tatsunori, Hosooka Tetsuya, Shinohara Masakazu, Kitahama Seiichi, Sasaki Kengo, Sasaki Daisuke, Yoneshiro Takeshi, Suzuki Tomohiro, Emoto Takuo, Saito Yoshihiro, Ozawa Genki, Hirota Yushi, Kitaura Yasuyuki, Shimomura Yoshiharu, Okamatsu-Ogura Yuko, Saito Masayuki, Kondo Akihiko, Kajimura Shingo, Inagaki Takeshi, Ogawa Wataru, Yamada Takuji, Hirata Ken-ichi

    ISCIENCE   Vol. 24 ( 11 ) page: 103342   2021.11

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  30. Branched-chain amino acids regulate hyaluronan synthesis and PPAR alpha expression in the skin

    Yamane Takumi, Kitaura Yasuyuki, Iwatsuki Ken, Shimomura Yoshiharu, Oishi Yuichi

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 85 ( 11 ) page: 2292 - 2294   2021.11

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  31. Supplementation of 1-Kestose Modulates the Gut Microbiota Composition to Ameliorate Glucose Metabolism in Obesity-Prone Hosts

    Watanabe Ayako, Tochio Takumi, Kadota Yoshihiro, Takahashi Motoki, Kitaura Yasuyuki, Ishikawa Hirohito, Yasutake Takanori, Nakano Masahiro, Shinohara Hiroe, Kudo Toru, Nishimoto Yuichiro, Mizuguchi Yoshinori, Endo Akihito, Shimomura Yoshiharu

    NUTRIENTS   Vol. 13 ( 9 )   2021.9

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  32. 1-Kestose supplementation mitigates the progressive deterioration of glucose metabolism in type 2 diabetes OLETF rats

    Watanabe Ayako, Kadota Yoshihiro, Kamio Rina, Tochio Takumi, Endo Akihito, Shimomura Yoshiharu, Kitaura Yasuyuki

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 15674   2020.9

  33. BDK Deficiency in Cerebral Cortex Neurons Causes Neurological Abnormalities and Affects Endurance Capacity

    Mizusawa Anna, Watanabe Ayako, Yamada Minori, Kamei Rina, Shimomura Yoshiharu, Kitaura Yasuyuki

    NUTRIENTS   Vol. 12 ( 8 )   2020.8

  34. Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure

    Nakano Ippei, Hori Hiroaki, Fukushima Arata, Yokota Takashi, Kinugawa Shintaro, Takada Shingo, Yamanashi Katsuma, Obata Yoshikuni, Kitaura Yasuyuki, Kakutani Naoya, Abe Takahiro, Anzai Toshihisa

    JOURNAL OF CARDIAC FAILURE   Vol. 26 ( 8 ) page: 685 - 693   2020.8

  35. Branched-chain amino acid supplementation ameliorates angiotensin II-induced skeletal muscle atrophy

    Yamanashi Katsuma, Kinugawa Shintaro, Fukushima Arata, Kakutani Naoya, Takada Shingo, Obata Yoshikuni, Nakano Ippei, Yokota Takashi, Kitaura Yasuyuki, Shimomura Yoshiharu, Anzai Toshihisa

    LIFE SCIENCES   Vol. 250   page: 117593   2020.6

  36. Reply to Comment on Watanabe, A.; Kadota, Y.; Yokoyama, H.; Tsuruda, S.; Kamio, R.; Tochio, T.; Shimomura, Y.; Kitaura, Y. Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats. Foods 2020, 9, 4

    Watanabe Ayako, Kadota Yoshihiro, Tochio Takumi, Shimomura Yoshiharu, Kitaura Yasuyuki

    FOODS   Vol. 9 ( 4 )   2020.4

  37. Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats

    Watanabe Ayako, Kadota Yoshihiro, Yokoyama Hijiri, Tsuruda Shunya, Kamio Rina, Tochio Takumi, Shimomura Yoshiharu, Kitaura Yasuyuki

    FOODS   Vol. 9 ( 1 )   2020.1

  38. Effect of Genetically Decreased BCAA Concentration on Glucose Tolerance in Mice

    Kitaura Yasuyuki, Senda Soushi, Shimomura Yoshiharu

    ANNALS OF NUTRITION AND METABOLISM   Vol. 75   page: 306 - 307   2019

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  39. Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions

    Shimomura Yoshiharu, Kitaura Yasuyuki

    PHARMACOLOGICAL RESEARCH   Vol. 133   page: 215 - 217   2018.7

  40. SPORTS NUTRITION FOR ACTIVE LIFE-STYLE

    Shimomura Yoshiharu, Kitaura Yasuyuki

    ANNALS OF NUTRITION AND METABOLISM   Vol. 71   page: 1362 - 1362   2017

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  41. PGC-1α-mediated branched-chain amino acid metabolism in the skeletal muscle.

    Hatazawa Y, Tadaishi M, Nagaike Y, Morita A, Ogawa Y, Ezaki O, Takai-Igarashi T, Kitaura Y, Shimomura Y, Kamei Y, Miura S.

    PLoS One   Vol. 9 ( 3 ) page: e91006   2014

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    DOI: 10.1371/journal.pone.0091006

  42. Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats

    Mochizuki, M., Takayanagi, H., Yamada, S., Osawa, T., Kitaura, Y., Shimomura, Y.

    J. Phys. Fitness Sports Med.   Vol. 2 ( 4 ) page: 509-513   2013

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  43. Regulation of hepatic branched-chain α-ketoacid dehydrogenase complex in rats fed a high-fat diet

    Kadota, Y., Toyoda, T., Kitaura, Y., Adams, S.H., Shimomura, Y.

    Obesity Research & Clinical Practice   Vol. 7 ( 6 ) page: e439-e444   2013

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    DOI: 10.1016/j.orcp.2013.07.003

  44. Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigens.

    Chikazawa, M., Otaki, N., Shibata, T., Miyashita, H., Kawai, Y., Maruyama, S., Toyokuni, S., Kitaura, Y., Matsuda, T., Uchida, K.

    J. Biol. Chem.   Vol. 288 ( 19 ) page: 13204-14   2013

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  45. Clofibrate-Induced Reduction of Plasma Branched-Chain Amino Acid Concentrations Impairs Glucose Tolerance in Rats

    Kadota, Y., Kazama, S., Bajotto, G., Kitaura, Y., Shimomura, Y.

    JPEN J. Parenter. Enteral. Nutr.   Vol. 36   page: 337-343   2012

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    DOI: 10.1177/0148607111414578

  46. 分岐鎖アミノ酸の生理機能の多様性

    下村吉治、北浦靖之、門田吉弘

    生化学   Vol. 84 ( 11 ) page: 8-12   2012

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  47. Effects of protein and amino acid supplementation on muscle protein metabolism in relation to exercise.

    Shimomura, Y., Kitaura, Y., and Shimomura, N.

    J. Phys. Fitness Sports Med.   Vol. 1   page: 219-225   2012

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  48. Multiple factors and pathways involved in hepatic very low density lipoprotein-apoB100 overproduction in Otsuka Long-Evans Tokushima Fatty Rats. Reviewed

    Qin, B., Anderson, R.A., Kuzuya, T., Kitaura, Y., and Shimomura, Y.

    Atherosclerosis   Vol. 222   page: 409-416   2012

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  49. Effects of Branched-Chain Amino Acid Supplementation on Plasma Concentrations of Free Amino Acids, Insulin, and Energy Substrates in Young Men. Reviewed

    J. Nutr. Sci. Vitaminol.   Vol. 57 ( 1 ) page: 114   2011

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  50. Effect of branched-chain amino acid supplementation during unloading on regulatory components of protein synthesis in atrophied soleus muscles Reviewed

    Bajotto G, Sato Y, Kitaura Y, Shimomura Y.

    Eur. J. Appl. Physiol.   Vol. in press   2011

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    DOI: 10.1007/s00421-010-1825-8

  51. Branched-chain amino acids (BCAAs) as nutraceuticals for exercise

    Shimomura, Y., Kitaura, Y., Sato, J.

    Journal of Exercise Nutrition & Biochemistry   Vol. 15 ( 3 ) page: 115-118   2011

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  52. Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease. Reviewed

    Doisaki M, Katano Y, Nakano I, Hirooka Y, Itoh A, Ishigami M, Hayashi K, Goto H, Fujita Y, Kadota Y, Kitaura Y, Bajotto G, Kazama S, Tamura T, Tamura N, Feng GG, Ishikawa N, Shimomura Y.

    Biochem. Biophys. Res. Commun.   Vol. 393 ( 2 ) page: 303   2010

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  53. The mouse resources at the RIKEN BioResource center. Reviewed

    Yoshiki, A., Ike, F., Mekada, K., Kitaura, Y., Nakata, H., Hiraiwa, N., Mochida, K., Ijuin, M., Kadota, M., Murakami, A., Ogura, A., Abe, K., Moriwaki, K., Obata, Y.

    Exp. Anim.   Vol. 58   page: 85-96   2009

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  54. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Reviewed

    Kitaura, Y., Jang, I.K., Wang, Y., Han, Y.C., Inazu, T., Cadera, E.J., Schlissel, M., Hardy, R.R., Gu, H.

    Immunity   Vol. 26 ( 5 ) page: 567-578   2007

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  55. Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins. Reviewed

    Huang, F.*, Kitaura, Y.*, Jang, I., Naramura, M., Kole, H.H., Liu, L., Qin, H., Schlissel, M.S., Gu, H. (*These authors contributed equally to this work.)

    Immunity   Vol. 25 ( 4 ) page: 571-581   2006

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  56. PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Reviewed

    Pasqualucci, L., Kitaura, Y., Gu, H., Dalla-Favera, R.

    Proc. Natl. Acad. Sci. U. S. A.   Vol. 103 ( 2 ) page: 395-400   2006

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  57. The penta-EF-hand protein ALG-2 interacts with a region containing PxY repeats in Alix/AIP1, which is required for the subcellular punctate distribution of the amino-terminal truncation form of Alix/AIP1 Invited Reviewed

    Shibata H, Yamada K, Mizuno T, Yorikawa C, Takahashi H, Satoh H, Kitaura Y, Maki M

    J Biochem   Vol. 135 ( 1 ) page: 117   2004

  58. Both ALG-2 and peflin, penta-EF-hand (PEF) proteins, are stabilized by dimerization through their fifth EF-hand regions. Invited Reviewed

    Kitaura Y, Satoh H, Takahashi H, Shibata H, Maki M

    Arch Biochem Biophys. 399(1): 12-18   Vol. 399 ( 1 ) page: 12   2002

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  59. ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca2+-dependent manner Reviewed

      Vol. 291 ( 5 ) page: 1166   2002

  60. Peflin and ALG-2, members of the penta-EF-hand protein family, form a heterodimer that dissociates in a Ca2+-dependent manner Reviewed

    Kitaura Y, Matsumoto S, Satoh H, Hitomi K, Maki M

    J Biol Chem   Vol. 276 ( 17 ) page: 14053   2001

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  61. Peflin, a novel member of the five-EF-hand-protein family, is similar to the apoptosis-linked gene 2 (ALG-2) protein but possesses nonapeptide repeats in the N-terminal hydrophobic region Reviewed

    Kitaura Y, Watanabe M, Satoh H, Kawai T, Hitomi K, Maki M

    Biochem Biophys Res Commun   Vol. 263 ( 1 ) page: 68   1999

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    Authorship:Lead author  

  62. Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Reviewed

    Takahashi C, Sheng Z, Horan TP, Kitayama H, Maki M, Hitomi K, Kitaura Y, Takai S, Sasahara RM, Horimoto A, Ikawa Y, Ratzkin BJ, Arakawa T, Noda M

    Proc Natl Acad Sci U S A.   Vol. 95 ( 22 ) page: 13221   1998

  63. Calcium-induced exposure of a hydrophobic surface of mouse ALG-2, which is a member of the penta-EF-hand protein family. Reviewed

    Maki M, Yamaguchi K, Kitaura Y, Satoh H, Hitomi K

    Biochem Biophys Res Commun   Vol. 124 ( 6 ) page: 1170   1998

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Research Project for Joint Research, Competitive Funding, etc. 5

  1. 分岐鎖アミノ酸分解促進による走運動持久力への影響

    2020.4 - 2021.3

    酵素研究助成事業 酵素研究助成 

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    Grant type:Competitive

    Grant amount:\1000000

  2. 運動トレーニングの適応反応機構における分岐鎖アミノ酸の役割

    2016.4 - 2017.3

    日本栄養・食糧学会 学術基金 

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    Grant type:Competitive

  3. フラクトオリゴ糖の生理作用

    2015.4

    国内共同研究 

  4. 分岐鎖アミノ酸の生理機能の解明

    2012.4 - 2013.3

    研究奨励金 

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    Grant type:Competitive

  5. 異種脂肪酸の組み合わせによるがん抑制法の開発

    2011.12 - 2012.7

    A-STEP 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. 肥満・インスリン抵抗性におけるアミノ酸代謝フロー変化の解明とその応用

    Grant number:21H02138  2021.4 - 2024.3

    北浦 靖之

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    Authorship:Principal investigator 

    Grant amount:\17420000 ( Direct Cost: \13400000 、 Indirect Cost:\4020000 )

  2. Mechanisms responsible for skeletal muscle atrophy induced by vitamin D deficiency

    Grant number:20H02942  2020.4 - 2024.3

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    Authorship:Coinvestigator(s) 

  3. D-アミノ酸シグナリングの分子機構:その解明と展開

    Grant number:19H02882  2019.4 - 2022.3

    吉村 徹

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    Authorship:Coinvestigator(s) 

    D-アミノ酸は哺乳動物にも広く存在し、シグナル分子として多様な生理機能を担う。例えば D-セリンはN-メチルD-アスパラギン酸レセプターのコアゴニストとして記憶や学習など脳の高次機能に関わる。D-アスパラギン酸は神経伝達や生殖に関係する可能性がある。本研究では未だ十全ではないD-アミノ酸のシグナル機能の分子レベルで解明を目指すとともに、D-アミノ酸を腎臓病の病態診断や筋萎縮性側索硬化症(ALS)の進行抑制へ応用する。さらに現在不分明のD-Asp合成酵素などの解明のためのツールとなる新奇D-アミノ酸生合成酵素遺伝子のファンクショナルスクリーニング系を開発する。

  4. Basic research for development of functional foods to enhance energy metabolism by modulating amino acid catabolism

    Grant number:17H01965  2017.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Kitaura Yasuyuki

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    Authorship:Principal investigator 

    Grant amount:\18070000 ( Direct Cost: \13900000 、 Indirect Cost:\4170000 )

    We analyzed the effects of accelerated catabolism of branched chain amino acids (BCAA: Leu, Ile, Val) on endurance capacity, obesity and insulin resistance, and protein synthesis and degradation. First, we discovered a novel activator for BCAA catabolism, and clarified its mechanism of activation in vitro and its effect on plasma BCAA concentrations in vivo. In addition, we revealed that BCAA catabolism was promoted by vitamin B1 in vivo and the effects of vitamin B1 intake or genetically promoted BCAA catabolism on running endurance, obesity and insulin resistance. Furthermore, we also found that the response of mTORC1 to BCAA was influenced by accelerated BCAA metabolism and dietary protein content.

  5. Physiological functions of branched-chain amino acids as regulatory factors in mammals

    Grant number:17H03817  2017.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    SHIMOMURA Yoshiharu

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    Authorship:Coinvestigator(s) 

    Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) have drawn attention as metabolic regulators in cells due to the diverse physiological actions. In the present study, we elucidated the mechanism that branched-chain α-keto acid dehydrogenase kinase (BDK), a regulator of BCAA metabolism, is controlled by Ca ions in cells. In the studies using conditional BDK-KO mice, we demonstrated that chronically low levels of BCAAs in skeletal muscle resulted in enhanced reactivity of muscle mTORC1, and slow recovery of muscle glycogen after exercise. Furthermore, we suggested that chronically low levels of BCAAs in brain were responsible for neurological abnormality.

  6. Importance of amino acid nutrition for maintaining heart function

    Grant number:16K14924  2016.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    Kitaura Yasuyuki, SHIMOMURA Yoshiharu

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    Authorship:Principal investigator 

    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

    In this study, we investigated the importance of BCAA (Branched chain amino acid) for maintaining heart function using the mice in which BCAAs are decreased by enhanced degradation of BCAA specifically in heart and skeletal muscle (BDK-mKO mice). There was no significant difference in heart weight between control and BDK-mKO mice at young age, however, the middle-aged BDK-mKO mice, especially in the case of feeding high-fat diet, showed significantly increased heart weight and cardiac hypertrophy-related genes which were decreased by BCAA administration.

  7. 哺乳動物における生体調節因子としての分岐鎖アミノ酸の生理機能

    2014.4 - 2018.3

    科学研究費補助金  基盤研究(B)

    下村 吉治

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    Authorship:Coinvestigator(s) 

  8. 脂肪酸の組み合せによる脂肪毒性誘導メカニズムの解明

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 22

  1. 基礎セミナー

    2019

  2. 応用生命科学実験実習

    2019

  3. 情報リテラシー

    2019

  4. 栄養科学

    2019

  5. Agricultural science

    2019

  6. 情報リテラシー

    2018

  7. 基礎セミナー

    2018

  8. Agricultural science

    2018

  9. 応用生命科学実験実習

    2018

  10. Agricultural science

    2017

  11. 応用生命科学実験実習

    2017

  12. Agricultural science

    2016

  13. 応用生命科学実験実習

    2016

  14. Agricultural science

    2015

  15. 応用生命科学実験実習

    2015

  16. 応用生命科学実験実習

    2014

  17. 応用生命科学実験実習

    2013

  18. 応用生命科学実験実習

    2012

  19. 情報リテラシー

    2011

  20. 応用生命科学実験実習

    2011

  21. 応用生命科学実験実習

    2010

  22. 応用生命科学実験実習

    2009

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