論文 - 柴田 貴広
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Dietary anthocyanidin pelargonidin activates G protein-coupled receptor 35. Open Access
Nakashima F, Shimomura S, Wakabayashi M, Loh WQ, Ando H, Sei H, Hattori H, Utomo DH, Kita M, Inoue A, Uchida K, Shibata T
The FEBS journal 2025年10月
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Isocitrate dehydrogenase 1 upregulation in urinary extracellular vesicles from proximal tubules of type 2 diabetic rats 査読有り 国際誌 Open Access
Sei, H; Hirade, N; Kamiya, K; Nakashima, F; Yoshitake, J; Kano, K; Mishiro-Sato, E; Kikuchi, R; Uchida, K; Shibata, T
FASEB JOURNAL 38 巻 ( 10 ) 頁： e23688 2024年5月
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Adductome-based identification of lysine mono-methylation as a key post-translational protein modification in autoimmune diseases. 査読有り 国際誌 Open Access
Yamaguchi K, Hu YY, Kawajiri K, Itakura M, Nakashima F, Shibata T, Uchida K
The Journal of biological chemistry 頁： 110684 2025年9月
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Effect of 1-Kestose on Lipid Metabolism in a High-Fat-Diet Rat Model 査読有り 国際誌 Open Access
Kuramitsu, K; Kubo, M; Cindy, F; Shibata, T; Kadota, Y; Kitaura, Y
NUTRIENTS 17 巻 ( 8 ) 2025年4月
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Inhibition of Lysosomal Cathepsin A and Neuraminidase 1 Interaction by Anti-Obesity Cyclic Peptide 査読有り Open Access
Sun, YT; Dakiiwa, A; Zhang, MH; Shibata, T; Kita, M
CHEMISTRY-A EUROPEAN JOURNAL 30 巻 ( 56 ) 頁： e202402049 2024年10月
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Okamoto, T; Nakashima, F; Shibata, T; Mori, D
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 88 巻 ( 8 ) 頁： 948 - 955 2024年6月
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Tetrachloroaurate (III)-induced oxidation increases nonthermal plasma-induced aldehydes 査読有り 国際誌 Open Access
Okazaki, Y; Yoshitake, J; Ito, N; Sasaki, K; Tanaka, H; Hori, M; Shibata, T; Toyokuni, S
ADVANCES IN REDOX RESEARCH 9 巻 2023年12月
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Eriodictyol and thymonin act as GPR35 agonists 査読有り 国際誌
Nakashima Fumie, Loh Wei Qi, Wakabayashi Mayuka, Shimomura Sayako, Hattori Hiroyuki, Kita Masaki, Inoue Asuka, Uchida Koji, Shibata Takahiro
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 2023年9月
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The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis 査読有り 国際共著 国際誌 Open Access
Nakashima Fumie, Gimenez-Bastida Juan A., Luis Paula B., Presley Sai H., Boer Robert E., Chiusa Manuel, Shibata Takahiro, Sulikowski Gary A., Pozzi Ambra, Schneider Claus
JOURNAL OF BIOLOGICAL CHEMISTRY 299 巻 ( 4 ) 頁： 103050 2023年4月
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Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis 査読有り 国際共著 国際誌 Open Access
Okuda Kosaku, Nakahara Kengo, Ito Akihiro, Iijima Yuta, Nomura Ryosuke, Kumar Ashutosh, Fujikawa Kana, Adachi Kazuya, Shimada Yuki, Fujio Satoshi, Yamamoto Reina, Takasugi Nobumasa, Onuma Kunishige, Osaki Mitsuhiko, Okada Futoshi, Ukegawa Taichi, Takeuchi Yasuo, Yasui Norihisa, Yamashita Atsuko, Marusawa Hiroyuki, Matsushita Yosuke, Katagiri Toyomasa, Shibata Takahiro, Uchida Koji, Niu Sheng-Yong, Lang Nhi B., Nakamura Tomohiro, Zhang Kam Y. J., Lipton Stuart A., Uehara Takashi
NATURE COMMUNICATIONS 14 巻 ( 1 ) 頁： 621 2023年2月
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Neuritogenic steroid glycosides from crown-of-thorns starfish: Possible involvement of p38 mitogen-activated protein kinase and attenuation of cognitive impairment in senescence-accelerated mice (SAMP8) by peripheral administration 査読有り 国際共著 国際誌
Sasayama Yumi, Mamiya Takayoshi, Qi Jianhua, Shibata Takahiro, Uchida Koji, Nabeshima Toshitaka, Ojika Makoto
BIOORGANIC & MEDICINAL CHEMISTRY 78 巻 頁： 117144 2023年1月
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Metabolomics of small extracellular vesicles derived from isocitrate dehydrogenase 1-mutant HCT116 cells collected by semi-automated size exclusion chromatography 招待有り 査読有り 国際誌 Open Access
Hayasaka Ryosuke, Tabata Sho, Hasebe Masako, Ikeda Satsuki, Hikita Tomoya, Oneyama Chitose, Yoshitake Jun, Onoshima Daisuke, Takahashi Kumiko, Shibata Takahiro, Uchida Koji, Baba Yoshinobu, Soga Tomoyoshi, Tomita Masaru, Hirayama Akiyoshi
FRONTIERS IN MOLECULAR BIOSCIENCES 9 巻 頁： 1049402 2023年1月
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Tetrachloroaurate (III)–induced oxidation increases nonthermal plasma-induced aldehydes 招待有り 査読有り
3. Okazaki Y, Yoshitake J, Ito N, Sasaki K, Tanaka H, Hori M, Shibata T, Toyokuni S.
Adv. Redox Res. 9 巻 頁： 10004 2023年
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Molecular networking-based lipid profiling and multi-omics approaches reveal new contributions of functional vanilloids to gut microbiota and lipometabolism changes 査読有り 国際誌 Open Access
Hattori Hiroyuki, Moriyama Akihiro, Ohno Tomoki, Shibata Takahiro, Iwahashi Hitoshi, Mitsunaga Tohru
FOOD CHEMISTRY: MOLECULAR SCIENCES 5 巻 頁： 100123 2022年12月
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Autoxidation of ascorbate mediates lysine N-pyrrolation 査読有り 国際誌
Yoshitake Jun, Shibata Takahiro, Chikazawa Miho, Uchida Koji
FREE RADICAL RESEARCH 56 巻 ( 11-12 ) 頁： 749 - 759 2022年12月
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Rapid Isolation of Extracellular Vesicles Using a Hydrophilic Porous Silica Gel-Based Size-Exclusion Chromatography Column 査読有り Open Access
Yoshitake Jun, Azami Mayuko, Sei Haruka, Onoshima Daisuke, Takahashi Kumiko, Hirayama Akiyoshi, Uchida Koji, Baba Yoshinobu, Shibata Takahiro
ANALYTICAL CHEMISTRY 94 巻 ( 40 ) 頁： 13676 - 13681 2022年9月
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Histone functions as a cell-surface receptor for AGEs 査読有り Open Access
Itakura Masanori, Yamaguchi Kosuke, Kitazawa Roma, Lim Sei-Young, Anan Yusuke, Yoshitake Jun, Shibata Takahiro, Negishi Lumi, Sugawa Hikari, Nagai Ryoji, Uchida Koji
NATURE COMMUNICATIONS 13 巻 ( 1 ) 頁： 2974 2022年5月
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Redox-dependent internalization of the purinergic P2Y(6) receptor limits colitis progression 査読有り 国際共著
Nishiyama Kazuhiro, Nishimura Akiyuki, Shimoda Kakeru, Tanaka Tomohiro, Kato Yuri, Shibata Takahiro, Tanaka Hiroshi, Kurose Hitoshi, Azuma Yasu-Taka, Ihara Hideshi, Kumagai Yoshito, Akaike Takaaki, Eaton Philip, Uchida Koji, Nishida Motohiro
SCIENCE SIGNALING 15 巻 ( 716 ) 頁： eabj0644 2022年1月
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Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution 査読有り Open Access
Kinoshita Remi, Kozaki Ikko, Shimizu Kazunori, Shibata Takahiro, Ochiai Akihito, Honda Hiroyuki
ACS OMEGA 6 巻 ( 46 ) 頁： 31244 - 31252 2021年11月
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Low-molecular-weight whey proteins promote collagen production in dermal fibroblasts via the TGF-beta receptor/Smad pathway 査読有り
Katayoshi Takeshi, Kusano Yuri, Shibata Takahiro, Uchida Koji, Tsuji-Naito Kentaro
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 85 巻 ( 11 ) 頁： 2232 - 2240 2021年11月
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Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified 査読有り Open Access
Tanaka Hiromasa, Hosoi Yugo, Ishikawa Kenji, Yoshitake Jun, Shibata Takahiro, Uchida Koji, Hashizume Hiroshi, Mizuno Masaaki, Okazaki Yasumasa, Toyokuni Shinya, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru
SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 18488 2021年9月
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Oxidative deamination of lysine residues by polyphenols generates an equilibrium of aldehyde and 2-piperidinol products 査読有り Open Access
Yamaguchi Kosuke, Itakura Masanori, Kitazawa Roma, Lim Sei-Young, Nagata Koji, Shibata Takahiro, Akagawa Mitsugu, Uchida Koji
JOURNAL OF BIOLOGICAL CHEMISTRY 297 巻 ( 3 ) 頁： 101035 2021年9月
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6-Paradol Acts as a Potential Anti-obesity Vanilloid from Grains of Paradise 査読有り 国際誌
Hattori Hiroyuki, Mori Takashi, Shibata Takahiro, Kita Masaki, Mitsunaga Tohru
MOLECULAR NUTRITION & FOOD RESEARCH 65 巻 ( 16 ) 頁： e2100185 2021年8月
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Identification of biosynthetic intermediates for the mating hormone alpha 2 of the plant pathogen Phytophthora 査読有り Open Access
Ariyoshi Suguru, Imazu Yusuke, Ohguri Ryuji, Katsuta Ryo, Yajima Arata, Shibata Takahiro, Ojika Makoto
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 85 巻 ( 8 ) 頁： 1802 - 1808 2021年7月
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Sodium sulfite causes gastric mucosal cell death by inducing oxidative stress 査読有り
Oshimo Moeri, Nakashima Fumie, Kai Kenji, Matsui Hirofumi, Shibata Takahiro, Akagawa Mitsugu
FREE RADICAL RESEARCH 55 巻 ( 6 ) 頁： 731 - 743 2021年6月
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Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution 査読有り
Yoshioka Keitaro, Yamashita Haruki, Shimizu Kazunori, Shimomura Sayako, Shibata Takahiro, Miyazaki Jun-ichi, Honda Hiroyuki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 550 巻 頁： 177 - 183 2021年4月
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Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor Open Access
Hasegawa Kana, Kuwata Keiko, Yoshitake Jun, Shimomura Sayako, Uchida Koji, Shibata Takahiro
FEBS JOURNAL 288 巻 ( 6 ) 頁： 1906 - 1917 2021年3月
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Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution. 招待有り 査読有り
Yoshioka K, Yamashita H, Shimizu K, Shimomura S, Shibata T, Miyazaki JI, Honda H.
Biochem. Biophys. Res. Commun. 550 巻 頁： 177 - 183 2021年
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PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates Open Access
Kamata Shotaro, Oyama Takuji, Saito Kenta, Honda Akihiro, Yamamoto Yume, Suda Keisuke, Ishikawa Ryo, Itoh Toshimasa, Watanabe Yasuo, Shibata Takahiro, Uchida Koji, Suematsu Makoto, Ishii Isao
ISCIENCE 23 巻 ( 11 ) 頁： 101727 2020年11月
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Acrolein in cigarette smoke attenuates the innate immune responses mediated by surfactant protein D
Takamiya Rina, Takahashi Motoko, Maeno Toshitaka, Saito Atsushi, Kato Masaki, Shibata Takahiro, Uchida Koji, Ariki Shigeru, Nakano Miyako
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1864 巻 ( 11 ) 頁： 129699 2020年11月
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Acyl-CoA dehydrogenase long chain (ACADL) is a target protein of stylissatin A, an anti-inflammatory cyclic heptapeptide
Zhang Menghua, Sunaba Taiki, Sun Yiting, Shibata Takahiro, Sasaki Kazunori, Isoda Hiroko, Kigoshi Hideo, Kita Masaki
JOURNAL OF ANTIBIOTICS 73 巻 ( 8 ) 頁： 589 - 592 2020年8月
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Isolation and structure-activity relationship studies of jacaranones: Anti-inflammatory quinoids from the Cuban endemic plant Jacaranda arborea (Bignoniaceae)
Hirukawa Minako, Zhang Menghua, Echenique-Diaz Lazaro M., Mizota Koji, Ohdachi Satoshi D., Begue-Quiala Gerardo, Delgado-Labanino Jorge L., Gamez-Diez Jorgelino, Alvarez-Lemus Jose, Galano Machado Leandro, Suarez Nunez Miguel, Shibata Takahiro, Kigoshi Hideo, Kita Masaki
Tetrahedron Letters 61 巻 ( 26 ) 2020年6月
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Glycolaldehyde is an endogenous source of lysine N-pyrrolation Open Access
Chikazawa Miho, Yoshitake Jun, Lim Sei-Young, Iwata Shiori, Negishi Lumi, Shibata Takahiro, Uchida Koji
JOURNAL OF BIOLOGICAL CHEMISTRY 295 巻 ( 22 ) 頁： 7697 - 7709 2020年5月
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Quantitative analysis of oxidized vitamin B1 metabolites generated by hypochlorous acid
Sasatsuki Hitoshi, Nakazaki Atsuo, Uchida Koji, Shibata Takahiro
FREE RADICAL BIOLOGY AND MEDICINE 152 巻 頁： 197 - 206 2020年5月
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Relationship among structure, cytotoxicity, and Michael acceptor reactivity of quinocidin Open Access
Nakagawa Yu, Sawaki Yuki, Miyanishi Wataru, Shimomura Sayako, Shibata Takahiro, Ojika Makoto
BIOORGANIC & MEDICINAL CHEMISTRY 28 巻 ( 4 ) 頁： 115308 2020年2月
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A unique mechanism for thiolation of serum albumins by disulphide molecules Open Access
Nakashima Fumie, Shibata Takahiro, Uchida Koji
JOURNAL OF BIOCHEMISTRY 167 巻 ( 2 ) 頁： 165 - 171 2020年2月
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Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B Open Access
Nho Cong Luong, Abiko Yumi, Shibata Takahiro, Uchida Koji, Warabi Eiji, Suzuki Midori, Noguchi Takuya, Matsuzawa Atsushi, Kumagai Yoshito
JOURNAL OF TOXICOLOGICAL SCIENCES 45 巻 ( 6 ) 頁： 349 - 363 2020年
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Protein adductomics: A comprehensive analysis of protein modifications by electrophiles Open Access
Shibata Takahiro, Uchida Koji
FREE RADICAL BIOLOGY AND MEDICINE 144 巻 頁： 218 - 222 2019年11月
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Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal (ONE) in preeclamptic placentas 査読有り 国際共著 国際誌 Open Access
Guerby Paul, Swiader Audrey, Tasta Oriane, Pont Frederic, Rodriguez Frederic, Parant Olivier, Vayssiere Christophe, Shibata Takahiro, Uchida Koji, Salvayre Robert, Negre-Salvayre Anne
FREE RADICAL BIOLOGY AND MEDICINE 141 巻 頁： 416 - 425 2019年9月
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A Dual Perspective of the Action of Lysine on Soybean Oil Oxidation Process Obtained by Combining <SUP>1</SUP>H NMR and LC-MS: Antioxidant Effect and Generation of Lysine-Aldehyde Adducts 査読有り 国際共著 国際誌 Open Access
Martin-Rubio Ana S., Sopelana Patricia, Nakashima Fumie, Shibata Takahiro, Uchida Koji, Guillen Maria D.
ANTIOXIDANTS 8 巻 ( 9 ) 2019年9月
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Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1 Open Access
Suzuki Takafumi, Muramatsu Aki, Saito Ryota, Iso Tatsuro, Shibata Takahiro, Kuwata Keiko, Kawaguchi Shin-ichi, Iwawaki Takao, Adachi Saki, Suda Hiromi, Morita Masanobu, Uchida Koji, Baird Liam, Yamamoto Masayuki
CELL REPORTS 28 巻 ( 3 ) 頁： 746 - + 2019年7月
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Apolipoprotein E binds to and reduces serum levels of DNA-mimicking, pyrrolated proteins Open Access
Hirose Sayumi, Hioki Yusuke, Miyashita Hiroaki, Hirade Naoya, Yoshitake Jun, Shibata Takahiro, Kikuchi Ryosuke, Matsushita Tadashi, Chikazawa Miho, Itakura Masanori, Zhang Mimin, Nagata Koji, Uchida Koji
JOURNAL OF BIOLOGICAL CHEMISTRY 294 巻 ( 28 ) 頁： 11035 - 11045 2019年7月
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2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct 査読有り 国際誌 Open Access
Yoshitake Jun, Shibata Takahiro, Shimayama Chihiro, Uchida Koji
REDOX BIOLOGY 23 巻 頁： 101115 2019年5月
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2-Oxo-histidine-containing dipeptides are functional oxidation products Open Access
Ihara Hideshi, Kakihana Yuki, Yamakage Akane, Kai Kenji, Shibata Takahiro, Nishida Motohiro, Yamada Ken-ichi, Uchida Koji
JOURNAL OF BIOLOGICAL CHEMISTRY 294 巻 ( 4 ) 頁： 1279-1289 2019年1月
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Diosgenin Supplementation Prevents Lipid Accumulation and Induces Skeletal Muscle-Fiber Hypertrophy in Rats Open Access
Kusano Yuri, Tsujihara Nobuko, Masui Hironori, Shibata Takahiro, Uchida Koji, Takeuchi Wakako
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 65 巻 ( 5 ) 頁： 421 - 429 2019年
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Development of a novel monoclonal antibody against 4-hydroxy-2E,6Z-dodecadienal (4-HDDE)-protein adducts: Immunochemical application in quantitative and qualitative analyses of lipid peroxidation in vitro and ex vivo
Uchida Koji, Shibata Takahiro, Toyokuni Shinya, Daniel Bareket, Zarkovic Kamelija, Zarkovic Neven, Sasson Shlomo
FREE RADICAL BIOLOGY AND MEDICINE 124 巻 頁： 12-20 2018年8月
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Structural and functional insights into S-thiolation of human serum albumins Open Access
Nakashima Fumie, Shibata Takahiro, Kamiya Kohei, Yoshitake Jun, Kikuchi Ryosuke, Matsushita Tadashi, Ishii Isao, Gimenez-Bastida Juan A., Schneider Claus, Uchida Koji
SCIENTIFIC REPORTS 8 巻 ( 1 ) 頁： 932 2018年1月
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Detection and quantification of 2-oxo-histidine-containing dipeptides
Ihara Hideshi, Kakihana Yuki, Yamakage Akane, Shibata Takahiro, Uchida Koji
FREE RADICAL BIOLOGY AND MEDICINE 112 巻 頁： 26 - 27 2017年11月
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Lipid radicals cause light-induced retinal degeneration 査読有り 国際誌
Enoki Masataka, Shinto Saki, Matsuoka Yuta, Otsuka Ayasa, Kaidzu Sachiko, Tanito Masaki, Shibata Takahiro, Uchida Koji, Ohira Akihiro, Yamatoa Mayumi, Yamada Ken-ichi
CHEMICAL COMMUNICATIONS 53 巻 ( 79 ) 頁： 10922 - 10925 2017年10月
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Identification of Polyphenol-Specific Innate Epitopes That Originated from a Resveratrol Analogue
Furuhashi Mai, Hatasa Yukinori, Kawarnura Sae, Shibata Takahiro, Akagawa Mitsugu, Uchida Koji
BIOCHEMISTRY 56 巻 ( 35 ) 頁： 4701-4712 2017年9月
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De Novo Synthesis of Possible Candidates for the Inagami-Tamura Endogenous Digitalis-like Factor Open Access
Nakazaki Atsuo, Hashimoto Keiko, Ikeda Ai, Shibata Takahiro, Nishikawa Toshio
JOURNAL OF ORGANIC CHEMISTRY 82 巻 ( 17 ) 頁： 9097-9111 2017年9月
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Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke Open Access
Takamiya Rina, Uchida Koji, Shibata Takahiro, Maeno Toshitaka, Kato Masaki, Yamaguchi Yoshiki, Ariki Shigeru, Hasegawa Yoshihiro, Saito Atsushi, Miwa Soichi, Takahashi Hiroki, Akaike Takaaki, Kuroki Yoshio, Takahashi Motoko
SCIENTIFIC REPORTS 7 巻 ( 1 ) 頁： 8304 2017年8月
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Adductome-based identification of biomarkers for lipid peroxidation Open Access
Shibata Takahiro, Shimizu Kazuma, Hirano Keita, Nakashima Fumie, Kikuchi Ryosuke, Matsushita Tadashi, Uchida Koji
JOURNAL OF BIOLOGICAL CHEMISTRY 292 巻 ( 20 ) 頁： 8223-8235 2017年5月
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Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes Open Access
Luis Paula B., Gordon Odaine N., Nakashima Fumie, Joseph Akil I., Shibata Takahiro, Uchida Koji, Schneider Claus
BIOCHEMICAL PHARMACOLOGY 132 巻 頁： 143-149 2017年5月
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Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E-2 and D-2 by activated human leukocytes Open Access
Gimenez-Bastida Juan A., Shibata Takahiro, Uchida Koji, Schneider Claus
FASEB JOURNAL 31 巻 ( 5 ) 頁： 1867-1878 2017年5月
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An open sandwich immunoassay for detection of 13(<i>R</i>,<i>S</i>)-hydroxy-9(<i>E</i>),11(<i>E</i>)-octadecadienoic acid 査読有り 国際共著
Dong Jinhua, Shichiri Mototada, Chung Chan-I., Shibata Takahiro, Uchida Koji, Hagihara Yoshihisa, Yoshida Yasukazu, Ueda Hiroshi
ANALYST 142 巻 ( 5 ) 頁： 787 - 793 2017年3月
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Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein Open Access
Kuan Yen-Chou, Hashidume Tsutomu, Shibata Takahiro, Uchida Koji, Shimizu Makoto, Inoue Jun, Sato Ryuichiro
JOURNAL OF BIOLOGICAL CHEMISTRY 292 巻 ( 7 ) 頁： 3016-3028 2017年2月
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Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes. 査読有り Open Access
Giménez-Bastida, J.A., Shibata, T., Uchida, K., & Schneider, C.
FASEB J. ３２ 巻 頁： 1867-1878 2017年
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Identification of C1q as a Binding Protein for Advanced Glycation End Products. 査読有り
Chikazawa, M., Shibata, T., Hatasa, Y., Hirose, S., Otaki, N., Nakashima, F., Ito, M., Machida, S., Maruyama, S., & Uchida, K.
55 巻 頁： 435-446 2016年
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Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein. 査読有り Open Access
Akagawa, M., Minematsu, K., Shibata, T., Kondo, T., Ishii, T., & Uchida K.
Sci Rep. 6 巻 頁： 26723 2016年
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Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-Gallate: A Potential Mechanism for the Formation of Innate Antigens by Antioxidants 査読有り Open Access
PLoS One. 11 巻 頁： e0153002 2016年
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Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. 査読有り Open Access
Shibata, T., Takahashi, K., Matsubara, Y., Inuzuka, E., Nakashima, F., Takahashi, N., Kozai, D., Mori, Y., & Uchida, K.
Sci. Rep. 6 巻 頁： 21261 2016年
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Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile. 査読有り Open Access
Kumagai, T., Usami, H., Matsukawa, N., Nakashima, F., Chikazawa, M., Shibata, T., Noguchi, N., and Uchida, K.
Redox Biol. 4 巻 頁： 74-86 2015年
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15-Deoxy-Δ12,14-prostaglandin J2 as an electrophilic mediator. 招待有り 査読有り
Shibata, T.
Biosci. Biotechnol. Biochem. 79 巻 頁： 1044-1049 2015年
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Toll-like receptors as a target of food-derived anti-inflammatory compounds. 査読有り Open Access
Shibata, T., Nakashima, F., Honda, K., Lu, Y.J., Kondo, T., Ushida, Y., Aizawa, K., Suganuma, H., Oe, S., Tanaka, H., Takahashi, T., and Uchida, K.
J. Biol. Chem. 289 巻 頁： 32757-32772. 2014年
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Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins. 査読有り Open Access
Miyashita, H., Chikazawa, M., Otaki, N., Hioki, Y., Shimozu, Y., Nakashima, F., Shibata, T., Hagihara, Y., Maruyama, S., Matsumi, N., Uchida, K. (2014)
Sci. Rep. 4 巻 頁： 5343 2014年
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An apoptosis-associated mammary protein deficiency leads to enhanced production of IgM antibodies against multiple damage-associated molecules. 査読有り
Chikazawa, M., Otaki, N., Shibata, T., Yasueda, T., Matsuda, T., and Uchida, K.
PLoS One 8 巻 頁： e68468. 2013年
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Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigens. 査読有り
1. Chikazawa, M., Otaki, N., Shibata, T., Miyashita, H., Kawai, Y., Maruyama, S., Toyokuni, S., Kitaura, Y., Matsuda, T., and Uchida, K.
J. Biol. Chem. 288 巻 頁： 13204-13214 2013年
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Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1. 査読有り
5. Kumano-Kuramochi, M., Shimozu, Y., Wakita, C., Ohnishi-Kameyama, M., Shibata, T., Matsunaga, S., Takano-Ishikawa, Y., Watanabe, J., Goto, M., Xie, Q., Komba, S., Uchida, K., and Machida, S
Biochem. J. 442 巻 頁： 171-180 2012年2月
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Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. 査読有り Open Access
Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T.
8 巻 頁： 714- 724 2012年
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Quantitative Analysis of Acrolein-Specific Adducts Generated during Lipid Peroxidation-Modification of Proteins in Vitro. 査読有り
25 巻 頁： 1384-1392 2012年
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Monoclonal Antibody against Protein-Bound Glutathione: Use of Glutathione Conjugate of Acrolein-Modified Proteins as an Immunogen. 査読有り
Chem. Res. Toxicol. 25 巻 頁： 1393-1401 2012年
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Constitutive expression of an antioxidant enzyme, glutathione S-transferase P1, during differentiation of human intestinal Caco-2 cells. 査読有り
53 巻 頁： 347-356 2012年
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Transthiocarbamoylation of proteins by thiolated isothiocyanates 査読有り
Shibata, T., Kimura, Y., Mukai, A., Mori, H., Ito, S., Asaka, Y., Oe, S., Tanaka, H., Takahashi, T., and Uchida, K.
J. Biol. Chem. 頁： in press 2011年
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4-Hydroperoxy-2-nonenal is not just an intermediate, but a reactive molecule that covalently modifies proteins to generate unique intramolecular oxidation products. 査読有り Open Access
Shimozu, Y., Hirano, K., Shibata, T., Shibata, N., and Uchida, K.
J. Biol. Chem. 286 巻 頁： 29313-29324. 2011年
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Lipid peroxidation modification of protein generates Nepsilon-(4-oxononanoyl)lysine as a pro-inflammatory ligand. . 査読有り
Shibata, T., Shimozu, Y., Wakita, C., Shibata, N., Kobayashi, M., Machida, S., Kato, R., Itabe, H., Zhu, X., Sayre, L. M., and Uchida, K.
J. Biol. Chem 286 巻 頁： 19943-19957. 2011年
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A method for detection of 4-hydroxy-2-nonenal adducts in proteins. 査読有り
Wakita, C., Honda, K., Shibata, T., Akagawa, M., and Uchida, K.
Free Radic. Biol. Med. 51 巻 頁： 1-4 2011年
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Delta12-Prostaglandin J2 as a Product and Ligand of Human Serum Albumin: Formation of an Unusual Covalent Adduct at His146. 査読有り
Yamaguchi, S., Aldini, G., Ito, S., Morishita, N., Shibata, T., Vistoli, G., Carini, M., Uchida, K.
J. Am. Chem. Soc. 132 巻 頁： 824-832 2010年
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Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-delta12,14-prostaglandin J2. 査読有り
Zhang, H.X., Tanji, K., Yoshida, H., Hayakari, M., Shibata, T., Mori, F., Uchida, K., Wakabayashi, K.
Exp. Neurol. 222 巻 頁： 296-303 2010年
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Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies. 査読有り
Otaki, N., Chikazawa, M., Nagae, R., Shimozu, Y., Shibata, T., Ito, S., Takasaki, Y., Fujii, J., and Uchida K.
J. Biol. Chem. 285 巻 頁： 33834-33842 2010年
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Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation. 査読有り
Nishida, M., Suda, R., Nagamatsu, Y., Tanabe, S., Onohara, N., Nakaya, M., Kanaho, Y., Shibata, T., Uchida, K., Sumimoto, H., Sato, Y., Kurose, H.
J. Biol. Chem. 285 巻 頁： 15268-15277 2010年
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Lipid peroxidation generates a body odor component trans-2-nonenal covalently bound to protein in vivo. 査読有り
Ishino, K., Wakita, C., Shibata, T., Toyokuni, S., Machida, S., Matsuda, S., Matsuda, T., Uchida, K.
J. Biol. Chem. 285 巻 頁： 15302-15313 2010年
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Lipid peroxidation generates a body odor component trans-2-nonenal covalently bound to protein in vivo. 査読有り
J. Biol. Chem. ( 285 ) 頁： 15302-15313 2010年
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Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy- delta12,14-prostaglandin J2. 査読有り
30) Zhang, H.X., Tanji, K., Yoshida, H., Hayakari, M., Shibata, T., Mori, F., Uchida, K., Wakabayashi, K.
Exp. Neurol. 222 巻 頁： 296-303 2010年
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Identification of advanced reaction products originating from the initial 4-oxo-2-nonenal-cysteine Michael adducts. 査読有り
Shimozu, Y., Shibata, T., Ojika, M., Uchida, K.
Chem. Res. Toxicol. 22 巻 頁： 957-964 2009年
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Immunohistochemical Detection of 13(R)-hydroxyoctadecadienoic Acid in Atherosclerotic Plaques of Human Carotid Arteries Using a Novel Specific Antibody. 査読有り Open Access
Shibata N, Toi S, Shibata T, Uchida K, Itabe H, Sawada T, Kawamata T, Okada Y, Uchiyama S, Kobayashi M.
Acta Histochem. Cytochem. 42 巻 頁： 197-203 2009年
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Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein. 査読有り
Wakita, C., Maeshima, T., Yamazaki, A., Shibata, T., Ito, S., Akagawa, M., Ojika, M., Yodoi, J., Uchida, K.
J. Biol. Chem. 284 巻 頁： 28810-28822 2009年
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15-Deoxy-Delta(12,14)-prostaglandin J2: An Electrophilic Trigger of Cellular Responses. 招待有り 査読有り
Uchida, K., & Shibata, T.
Chem. Res. Toxicol. 138-144. 21 巻 頁： 138-144 2008年1月
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*A food-derived synergist of NGF signaling: Identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction. 査読有り
Shibata T, Nakahara H, Kita N, Matsubara Y, Han C, Morimitsu Y, Iwamoto N, Kumagai Y, Nishida M, Kurose H, Aoki N, Ojika M, Uchida K.
J. Neurochem. 107 巻 ( 5 ) 頁： 1248-1260 2008年
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Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. 査読有り Open Access
Takahashi, N., Mizuno, Y., Kozai, D., Yamamoto, S., Kiyonaka, S., Shibata, T., Uchida, K., and Mori, Y.
Channels (Austin) 2 巻 頁： 287-298 2008年
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Protein N-Acylation: H2O2-Mediated Covalent Modification of Protein by Lipid Peroxidation-Derived Saturated Aldehydes. 査読有り
Ishino, K., Shibata, T., Ishii, T., Liu, Y. T., Toyokuni, S., Zhu, X., Sayre, L. M., and Uchida, K.
Chem. Res. Toxicol. 21 巻 頁： 1261-1270 2008年
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Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells. 査読有り
21) Kusano, Y., Horie, S., Shibata, T., Satsu, H., Shimizu, M., Hitomi, E., Nishida, M., Kurose, H., Itoh, K., Kobayashi, A., Yamamoto, M., and Uchida, K.
Biochemistry 47 巻 頁： 6169-6177 2008年
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Identification of a Serum Component That Regulates Cyclooxygenase-2 Gene Expression in Cooperation with 4-Hydroxy-2-nonenal. 査読有り
Kanayama M, Yamaguchi S, Shibata T, Shibata N, Kobayashi M, Nagai R, Arai H, Takahashi K, Uchida K.
J. Biol. Chem. 282 巻 ( 33 ) 頁： 24166-24174 2007年8月
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Granulatoside A, a Starfish Steroid Glycoside, Enhances PC12 Cell Neuritogenesis Induced by Nerve Growth Factor through an Activation of MAP Kinase. 査読有り
Qi J, Han C, Sasayama Y, Nakahara H, Shibata T, Uchida K, Ojika M.
ChemMedChem. 1 巻 頁： 1351-4 2007年
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Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. 査読有り
Mizutani, N., Sakurai, T., Shibata, T., Uchida, K., Fujita, J., Kawashima, R., Kawamura, Y. I., Toyama-Sorimachi, N., Imai, T., & Dohi, T.
J. Immunol. 179 巻 頁： 7478-87 2007年
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Protein-bound 4-Hydroxy-2-nonenal: AN ENDOGENOUS TRIGGERING ANTIGEN OF ANTI-DNA RESPONSE. 査読有り
Toyoda K, Nagae R, Akagawa M, Ishino K, Shibata T, Ito S, Shibata N, Yamamoto T, Kobayashi M, Takasaki Y, Matsuda T, Uchida K.
J. Biol. Chem. 282 巻 ( 35 ) 頁： 25769-25778 2007年
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Identification of Actin as a 15-Deoxy-Delta(12,14)-prostaglandin J(2) Target in Neuroblastoma Cells: Mass Spectrometric, Computational, and Functional Approaches To Investigate the Effect on Cytoskeletal Derangement. 査読有り
Aldini G, Carini M, Vistoli G, Shibata T, Kusano Y, Gamberoni L, Dalle-Donne I, Milzani A, Uchida K.
Biochemistry 46 巻 ( 10 ) 頁： 2707-2718 2007年
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Polymer-Assisted Solution-Phase Synthesis and Neurite-Outgrowth-Promoting Activity of 15-Deoxy- 12,14-PGJ2 Derivatives 査読有り
Tanaka H, Hasegawa T, Kita N, Nakahara H, Shibata T, Oe S, Ojika M, Uchida K, and Takahashi T.
Chemistry-An Asian Journal 1 巻 頁： 669-677 2007年
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ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. 査読有り Open Access
Kobayashi M, Ono H, Mihara K, Tauchi H, Komatsu K, Shibata T, Shimizu H, Uchida K, Yamamoto K.
Genes Cells 11 巻 ( 7 ) 頁： 779-789 2006年7月
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Prostaglandins from a zoanthid: Paclitaxel-like neurite-degenerating and microtubule-stabilizating activities. 査読有り Open Access
Han C, Qi J, Shi X, Sakagami Y, Shibata T, Uchida K, & Ojika M.
Biosci. Biotechnol. Biochem. 70 巻 頁： 706-11 2006年3月
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Bispecific abs against modified protein and DNA with oxidized lipids. 査読有り
Akagawa M, Ito S, Toyoda K, Ishii Y, Tatsuda E, Shibata T, Yamaguchi S, Kawai Y, Ishino K, Kishi Y, Adachi T, Tsubata T, Takasaki Y, Hattori N, Matsuda T, Uchida K.
Proc. Natl. Acad. Sci. USA 103 巻 頁： 6160-5 2006年
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Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. 査読有り
Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M.
Mol. Cell. Biol. 26 巻 ( 1 ) 頁： 221-229 2006年
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Metal-catalyzed oxidation of protein-bound dopamine. 査読有り
Akagawa M, Ishii Y, Ishii T, Shibata T, Yotsu-Yamashita M, Suyama K, Uchida K.
Biochemistry 45 巻 ( 50 ) 頁： 15120-8 2006年
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Ebselen, a Seleno-organic Antioxidant, as an Electrophile 査読有り
Sakurai, T., Kanayama, M., Shibata, T., Itoh, K., Kobayashi, A., Yamamoto, M., & Uchida, K.
Chem. Res. Toxicol. 19 巻 頁： 1196-204 2006年
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Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. 査読有り Open Access
Hosoya T, Maruyama A, Kang MI, Kawatani Y, Shibata T, Uchida K, Itoh K, & Yamamoto M.
J. Biol. Chem. 280 巻 頁： 27244-27250 2005年
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「J2型プロスタグランジン研究の現状」
柴田貴広、内田浩二
日本生化学会誌「生化学」 77 巻 頁： 1189-1192 2005年
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「野菜由来イソチオシアネートによる神経細胞分化誘導」
柴田貴広、中原寛子、内田浩二
食品工業 48 巻 頁： 63-67 2005年
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「プロスタグランジンJ2の化学と生物 -多様な生理活性とその分子過程-」 Open Access
柴田貴広、内田浩二
日本農芸化学会誌 「化学と生物」 43 巻 ( 1 ) 頁： 20-27 2005年
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*Identification of a lipid peroxidation product as a potential trigger of the p53 pathway. 査読有り Open Access
Shibata T, Iio K, Kawai Y, Shibata N, Kawaguchi M, Toi S, Kobayashi M, Kobayashi M, Yamamoto K, & Uchida K.
J. Biol. Chem. 281 巻 頁： 1196-1204 2005年
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Transcription Factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-delta12,14-prostaglandin J2. 査読有り
Itoh K, Mochizuki M, Ishii Y, Ishii T, Shibata T, Kawamoto Y, Kelly V, Sekizawa K, Uchida K, & Yamamoto M.
Mol. Cell. Biol. 24 巻 頁： 36-45 2004年
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Structural basis of protein-bound endogenous aldehydes : Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct. 査読有り
Hashimoto M, Shibata T, Wasada H, Toyokuni S, & Uchida K.
J. Biol. Chem 278 巻 頁： 5044-51 2003年
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An endogenous electrophile that modulates the regulatory mechanism of protein turnover. 査読有り
Biochemistry 42 巻 頁： 13960-13968 2003年
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Thioredoxin as a molecular target of cyclopentenone prostaglandins. 査読有り Open Access
Shibata T, Yamada T, Ishii T, Kumazawa S, Nakamura H, Masutani H, Yodoi J, & Uchida K
J. Biol.Chem 278 巻 頁： 26046-54 2003年
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15-Deoxy-delta12,14-prostaglandin J2: The endogenous electrophile that induces neuronal apoptosis 査読有り Open Access
Kondo M, Shibata T, Kumagai T, Osawa T, Shibata N, Kobayashi M, Sasaki S, Iwata M, Noguchi N, and Uchida K.
Proc. Natl. Acad. Sci. USA 99 巻 ( 11 ) 頁： 7367-7372 2002年
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15-Deoxy-delta12,14-prostaglandin J2: A PROSTAGLANDIN D2 METABOLITE GENERATED DURING INFLAMMATORY PROCESSES 査読有り
Shibata T, Kondo M, Osawa T, Shibata N, Kobayashi M, & Uchida K.
J. Biol. Chem. 277 巻 ( 12 ) 頁： 10459-10466 2002年