研究者詳細 - 柴田　貴広

論文 - 柴田　貴広

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Isocitrate dehydrogenase 1 upregulation in urinary extracellular vesicles from proximal tubules of type 2 diabetic rats 査読有り国際誌

Sei, H; Hirade, N; Kamiya, K; Nakashima, F; Yoshitake, J; Kano, K; Mishiro-Sato, E; Kikuchi, R; Uchida, K; Shibata, T

FASEB JOURNAL 38 巻 ( 10 ) 頁： e23688 2024年5月

Inhibition of Lysosomal Cathepsin A and Neuraminidase 1 Interaction by Anti-Obesity Cyclic Peptide 査読有り

Sun, YT; Dakiiwa, A; Zhang, MH; Shibata, T; Kita, M

CHEMISTRY-A EUROPEAN JOURNAL 30 巻 ( 56 ) 頁： e202402049 2024年10月

Seabuckthorn (Hippophae rhamnoides, L.) pulp oil prevents ultraviolet-induced damage in human fibroblasts 査読有り

Okamoto, T; Nakashima, F; Shibata, T; Mori, D

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 88 巻 ( 8 ) 頁： 948 - 955 2024年6月

Eriodictyol and thymonin act as GPR35 agonists 査読有り国際誌

Nakashima Fumie, Loh Wei Qi, Wakabayashi Mayuka, Shimomura Sayako, Hattori Hiroyuki, Kita Masaki, Inoue Asuka, Uchida Koji, Shibata Takahiro

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 2023年9月

The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis 査読有り国際共著国際誌

Nakashima Fumie, Gimenez-Bastida Juan A., Luis Paula B., Presley Sai H., Boer Robert E., Chiusa Manuel, Shibata Takahiro, Sulikowski Gary A., Pozzi Ambra, Schneider Claus

JOURNAL OF BIOLOGICAL CHEMISTRY 299 巻 ( 4 ) 頁： 103050 2023年4月

Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis 査読有り国際共著国際誌

Okuda Kosaku, Nakahara Kengo, Ito Akihiro, Iijima Yuta, Nomura Ryosuke, Kumar Ashutosh, Fujikawa Kana, Adachi Kazuya, Shimada Yuki, Fujio Satoshi, Yamamoto Reina, Takasugi Nobumasa, Onuma Kunishige, Osaki Mitsuhiko, Okada Futoshi, Ukegawa Taichi, Takeuchi Yasuo, Yasui Norihisa, Yamashita Atsuko, Marusawa Hiroyuki, Matsushita Yosuke, Katagiri Toyomasa, Shibata Takahiro, Uchida Koji, Niu Sheng-Yong, Lang Nhi B., Nakamura Tomohiro, Zhang Kam Y. J., Lipton Stuart A., Uehara Takashi

NATURE COMMUNICATIONS 14 巻 ( 1 ) 頁： 621 2023年2月

Neuritogenic steroid glycosides from crown-of-thorns starfish: Possible involvement of p38 mitogen-activated protein kinase and attenuation of cognitive impairment in senescence-accelerated mice (SAMP8) by peripheral administration 査読有り国際共著国際誌

Sasayama Yumi, Mamiya Takayoshi, Qi Jianhua, Shibata Takahiro, Uchida Koji, Nabeshima Toshitaka, Ojika Makoto

BIOORGANIC & MEDICINAL CHEMISTRY 78 巻頁： 117144 2023年1月

Metabolomics of small extracellular vesicles derived from isocitrate dehydrogenase 1-mutant HCT116 cells collected by semi-automated size exclusion chromatography 招待有り査読有り国際誌

Hayasaka Ryosuke, Tabata Sho, Hasebe Masako, Ikeda Satsuki, Hikita Tomoya, Oneyama Chitose, Yoshitake Jun, Onoshima Daisuke, Takahashi Kumiko, Shibata Takahiro, Uchida Koji, Baba Yoshinobu, Soga Tomoyoshi, Tomita Masaru, Hirayama Akiyoshi

FRONTIERS IN MOLECULAR BIOSCIENCES 9 巻頁： 1049402 2023年1月

Tetrachloroaurate (III)–induced oxidation increases nonthermal plasma-induced aldehydes 招待有り査読有り

3. Okazaki Y, Yoshitake J, Ito N, Sasaki K, Tanaka H, Hori M, Shibata T, Toyokuni S.

Adv. Redox Res. 9 巻頁： 10004 2023年

Molecular networking-based lipid profiling and multi-omics approaches reveal new contributions of functional vanilloids to gut microbiota and lipometabolism changes 査読有り国際誌

Hattori Hiroyuki, Moriyama Akihiro, Ohno Tomoki, Shibata Takahiro, Iwahashi Hitoshi, Mitsunaga Tohru

FOOD CHEMISTRY: MOLECULAR SCIENCES 5 巻頁： 100123 2022年12月

Autoxidation of ascorbate mediates lysine N-pyrrolation 査読有り国際誌

Yoshitake Jun, Shibata Takahiro, Chikazawa Miho, Uchida Koji

FREE RADICAL RESEARCH 56 巻 ( 11-12 ) 頁： 749 - 759 2022年12月

Rapid Isolation of Extracellular Vesicles Using a Hydrophilic Porous Silica Gel-Based Size-Exclusion Chromatography Column 査読有り

Yoshitake Jun, Azami Mayuko, Sei Haruka, Onoshima Daisuke, Takahashi Kumiko, Hirayama Akiyoshi, Uchida Koji, Baba Yoshinobu, Shibata Takahiro

ANALYTICAL CHEMISTRY 94 巻 ( 40 ) 頁： 13676 - 13681 2022年9月

Histone functions as a cell-surface receptor for AGEs 査読有り

Itakura Masanori, Yamaguchi Kosuke, Kitazawa Roma, Lim Sei-Young, Anan Yusuke, Yoshitake Jun, Shibata Takahiro, Negishi Lumi, Sugawa Hikari, Nagai Ryoji, Uchida Koji

NATURE COMMUNICATIONS 13 巻 ( 1 ) 頁： 2974 2022年5月

Redox-dependent internalization of the purinergic P2Y(6) receptor limits colitis progression 査読有り国際共著

Nishiyama Kazuhiro, Nishimura Akiyuki, Shimoda Kakeru, Tanaka Tomohiro, Kato Yuri, Shibata Takahiro, Tanaka Hiroshi, Kurose Hitoshi, Azuma Yasu-Taka, Ihara Hideshi, Kumagai Yoshito, Akaike Takaaki, Eaton Philip, Uchida Koji, Nishida Motohiro

SCIENCE SIGNALING 15 巻 ( 716 ) 頁： eabj0644 2022年1月

Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution 査読有り

Kinoshita Remi, Kozaki Ikko, Shimizu Kazunori, Shibata Takahiro, Ochiai Akihito, Honda Hiroyuki

ACS OMEGA 6 巻 ( 46 ) 頁： 31244 - 31252 2021年11月

Low-molecular-weight whey proteins promote collagen production in dermal fibroblasts via the TGF-beta receptor/Smad pathway 査読有り

Katayoshi Takeshi, Kusano Yuri, Shibata Takahiro, Uchida Koji, Tsuji-Naito Kentaro

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 85 巻 ( 11 ) 頁： 2232 - 2240 2021年11月

Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified 査読有り

Tanaka Hiromasa, Hosoi Yugo, Ishikawa Kenji, Yoshitake Jun, Shibata Takahiro, Uchida Koji, Hashizume Hiroshi, Mizuno Masaaki, Okazaki Yasumasa, Toyokuni Shinya, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru

SCIENTIFIC REPORTS 11 巻 ( 1 ) 頁： 18488 2021年9月

Oxidative deamination of lysine residues by polyphenols generates an equilibrium of aldehyde and 2-piperidinol products 査読有り

Yamaguchi Kosuke, Itakura Masanori, Kitazawa Roma, Lim Sei-Young, Nagata Koji, Shibata Takahiro, Akagawa Mitsugu, Uchida Koji

JOURNAL OF BIOLOGICAL CHEMISTRY 297 巻 ( 3 ) 頁： 101035 2021年9月

6-Paradol Acts as a Potential Anti-obesity Vanilloid from Grains of Paradise 査読有り国際誌

Hattori Hiroyuki, Mori Takashi, Shibata Takahiro, Kita Masaki, Mitsunaga Tohru

MOLECULAR NUTRITION & FOOD RESEARCH 65 巻 ( 16 ) 頁： e2100185 2021年8月

Identification of biosynthetic intermediates for the mating hormone alpha 2 of the plant pathogen Phytophthora 査読有り

Ariyoshi Suguru, Imazu Yusuke, Ohguri Ryuji, Katsuta Ryo, Yajima Arata, Shibata Takahiro, Ojika Makoto

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 85 巻 ( 8 ) 頁： 1802 - 1808 2021年7月

Sodium sulfite causes gastric mucosal cell death by inducing oxidative stress 査読有り

Oshimo Moeri, Nakashima Fumie, Kai Kenji, Matsui Hirofumi, Shibata Takahiro, Akagawa Mitsugu

FREE RADICAL RESEARCH 55 巻 ( 6 ) 頁： 731 - 743 2021年6月

Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution 査読有り

Yoshioka Keitaro, Yamashita Haruki, Shimizu Kazunori, Shimomura Sayako, Shibata Takahiro, Miyazaki Jun-ichi, Honda Hiroyuki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 550 巻頁： 177 - 183 2021年4月

Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor

Hasegawa Kana, Kuwata Keiko, Yoshitake Jun, Shimomura Sayako, Uchida Koji, Shibata Takahiro

FEBS JOURNAL 288 巻 ( 6 ) 頁： 1906 - 1917 2021年3月

Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution. 招待有り査読有り

Yoshioka K, Yamashita H, Shimizu K, Shimomura S, Shibata T, Miyazaki JI, Honda H.

Biochem. Biophys. Res. Commun. 550 巻頁： 177 - 183 2021年

PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates

Kamata Shotaro, Oyama Takuji, Saito Kenta, Honda Akihiro, Yamamoto Yume, Suda Keisuke, Ishikawa Ryo, Itoh Toshimasa, Watanabe Yasuo, Shibata Takahiro, Uchida Koji, Suematsu Makoto, Ishii Isao

ISCIENCE 23 巻 ( 11 ) 頁： 101727 2020年11月

Acrolein in cigarette smoke attenuates the innate immune responses mediated by surfactant protein D

Takamiya Rina, Takahashi Motoko, Maeno Toshitaka, Saito Atsushi, Kato Masaki, Shibata Takahiro, Uchida Koji, Ariki Shigeru, Nakano Miyako

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1864 巻 ( 11 ) 頁： 129699 2020年11月

Acyl-CoA dehydrogenase long chain (ACADL) is a target protein of stylissatin A, an anti-inflammatory cyclic heptapeptide

Zhang Menghua, Sunaba Taiki, Sun Yiting, Shibata Takahiro, Sasaki Kazunori, Isoda Hiroko, Kigoshi Hideo, Kita Masaki

JOURNAL OF ANTIBIOTICS 73 巻 ( 8 ) 頁： 589 - 592 2020年8月

Isolation and structure-activity relationship studies of jacaranones: Anti-inflammatory quinoids from the Cuban endemic plant Jacaranda arborea (Bignoniaceae)

Hirukawa Minako, Zhang Menghua, Echenique-Diaz Lazaro M., Mizota Koji, Ohdachi Satoshi D., Begue-Quiala Gerardo, Delgado-Labanino Jorge L., Gamez-Diez Jorgelino, Alvarez-Lemus Jose, Galano Machado Leandro, Suarez Nunez Miguel, Shibata Takahiro, Kigoshi Hideo, Kita Masaki

Tetrahedron Letters 61 巻 ( 26 ) 2020年6月

Glycolaldehyde is an endogenous source of lysine N-pyrrolation

Chikazawa Miho, Yoshitake Jun, Lim Sei-Young, Iwata Shiori, Negishi Lumi, Shibata Takahiro, Uchida Koji

JOURNAL OF BIOLOGICAL CHEMISTRY 295 巻 ( 22 ) 頁： 7697 - 7709 2020年5月

Quantitative analysis of oxidized vitamin B1 metabolites generated by hypochlorous acid

Sasatsuki Hitoshi, Nakazaki Atsuo, Uchida Koji, Shibata Takahiro

FREE RADICAL BIOLOGY AND MEDICINE 152 巻頁： 197 - 206 2020年5月

Relationship among structure, cytotoxicity, and Michael acceptor reactivity of quinocidin

Nakagawa Yu, Sawaki Yuki, Miyanishi Wataru, Shimomura Sayako, Shibata Takahiro, Ojika Makoto

BIOORGANIC & MEDICINAL CHEMISTRY 28 巻 ( 4 ) 頁： 115308 2020年2月

A unique mechanism for thiolation of serum albumins by disulphide molecules

Nakashima Fumie, Shibata Takahiro, Uchida Koji

JOURNAL OF BIOCHEMISTRY 167 巻 ( 2 ) 頁： 165 - 171 2020年2月

Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B

Nho Cong Luong, Abiko Yumi, Shibata Takahiro, Uchida Koji, Warabi Eiji, Suzuki Midori, Noguchi Takuya, Matsuzawa Atsushi, Kumagai Yoshito

JOURNAL OF TOXICOLOGICAL SCIENCES 45 巻 ( 6 ) 頁： 349 - 363 2020年

Protein adductomics: A comprehensive analysis of protein modifications by electrophiles

Shibata Takahiro, Uchida Koji

FREE RADICAL BIOLOGY AND MEDICINE 144 巻頁： 218 - 222 2019年11月

A Dual Perspective of the Action of Lysine on Soybean Oil Oxidation Process Obtained by Combining 1H NMR and LC-MS: Antioxidant Effect and Generation of Lysine-Aldehyde Adducts 査読有り国際共著国際誌

Martin-Rubio Ana S., Sopelana Patricia, Nakashima Fumie, Shibata Takahiro, Uchida Koji, Guillen Maria D.

ANTIOXIDANTS 8 巻 ( 9 ) 2019年9月

Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal (ONE) in preeclamptic placentas 査読有り国際共著国際誌

Guerby Paul, Swiader Audrey, Tasta Oriane, Pont Frederic, Rodriguez Frederic, Parant Olivier, Vayssiere Christophe, Shibata Takahiro, Uchida Koji, Salvayre Robert, Negre-Salvayre Anne

FREE RADICAL BIOLOGY AND MEDICINE 141 巻頁： 416 - 425 2019年9月

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

Suzuki Takafumi, Muramatsu Aki, Saito Ryota, Iso Tatsuro, Shibata Takahiro, Kuwata Keiko, Kawaguchi Shin-ichi, Iwawaki Takao, Adachi Saki, Suda Hiromi, Morita Masanobu, Uchida Koji, Baird Liam, Yamamoto Masayuki

CELL REPORTS 28 巻 ( 3 ) 頁： 746 - + 2019年7月

Apolipoprotein E binds to and reduces serum levels of DNA-mimicking, pyrrolated proteins

Hirose Sayumi, Hioki Yusuke, Miyashita Hiroaki, Hirade Naoya, Yoshitake Jun, Shibata Takahiro, Kikuchi Ryosuke, Matsushita Tadashi, Chikazawa Miho, Itakura Masanori, Zhang Mimin, Nagata Koji, Uchida Koji

JOURNAL OF BIOLOGICAL CHEMISTRY 294 巻 ( 28 ) 頁： 11035 - 11045 2019年7月

2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct 査読有り国際誌

Yoshitake Jun, Shibata Takahiro, Shimayama Chihiro, Uchida Koji

REDOX BIOLOGY 23 巻頁： 101115 2019年5月

2-Oxo-histidine-containing dipeptides are functional oxidation products

Ihara Hideshi, Kakihana Yuki, Yamakage Akane, Kai Kenji, Shibata Takahiro, Nishida Motohiro, Yamada Ken-ichi, Uchida Koji

JOURNAL OF BIOLOGICAL CHEMISTRY 294 巻 ( 4 ) 頁： 1279-1289 2019年1月

Diosgenin Supplementation Prevents Lipid Accumulation and Induces Skeletal Muscle-Fiber Hypertrophy in Rats

Kusano Yuri, Tsujihara Nobuko, Masui Hironori, Shibata Takahiro, Uchida Koji, Takeuchi Wakako

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 65 巻 ( 5 ) 頁： 421 - 429 2019年

Development of a novel monoclonal antibody against 4-hydroxy-2E,6Z-dodecadienal (4-HDDE)-protein adducts: Immunochemical application in quantitative and qualitative analyses of lipid peroxidation in vitro and ex vivo

Uchida Koji, Shibata Takahiro, Toyokuni Shinya, Daniel Bareket, Zarkovic Kamelija, Zarkovic Neven, Sasson Shlomo

FREE RADICAL BIOLOGY AND MEDICINE 124 巻頁： 12-20 2018年8月

Structural and functional insights into S-thiolation of human serum albumins

Nakashima Fumie, Shibata Takahiro, Kamiya Kohei, Yoshitake Jun, Kikuchi Ryosuke, Matsushita Tadashi, Ishii Isao, Gimenez-Bastida Juan A., Schneider Claus, Uchida Koji

SCIENTIFIC REPORTS 8 巻 ( 1 ) 頁： 932 2018年1月

Detection and quantification of 2-oxo-histidine-containing dipeptides

Ihara Hideshi, Kakihana Yuki, Yamakage Akane, Shibata Takahiro, Uchida Koji

FREE RADICAL BIOLOGY AND MEDICINE 112 巻頁： 26 - 27 2017年11月

Lipid radicals cause light-induced retinal degeneration 査読有り国際誌

Enoki Masataka, Shinto Saki, Matsuoka Yuta, Otsuka Ayasa, Kaidzu Sachiko, Tanito Masaki, Shibata Takahiro, Uchida Koji, Ohira Akihiro, Yamatoa Mayumi, Yamada Ken-ichi

CHEMICAL COMMUNICATIONS 53 巻 ( 79 ) 頁： 10922 - 10925 2017年10月

Identification of Polyphenol-Specific Innate Epitopes That Originated from a Resveratrol Analogue

Furuhashi Mai, Hatasa Yukinori, Kawarnura Sae, Shibata Takahiro, Akagawa Mitsugu, Uchida Koji

BIOCHEMISTRY 56 巻 ( 35 ) 頁： 4701-4712 2017年9月

De Novo Synthesis of Possible Candidates for the Inagami-Tamura Endogenous Digitalis-like Factor

Nakazaki Atsuo, Hashimoto Keiko, Ikeda Ai, Shibata Takahiro, Nishikawa Toshio

JOURNAL OF ORGANIC CHEMISTRY 82 巻 ( 17 ) 頁： 9097-9111 2017年9月

Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke

Takamiya Rina, Uchida Koji, Shibata Takahiro, Maeno Toshitaka, Kato Masaki, Yamaguchi Yoshiki, Ariki Shigeru, Hasegawa Yoshihiro, Saito Atsushi, Miwa Soichi, Takahashi Hiroki, Akaike Takaaki, Kuroki Yoshio, Takahashi Motoko

SCIENTIFIC REPORTS 7 巻 ( 1 ) 頁： 8304 2017年8月

Adductome-based identification of biomarkers for lipid peroxidation

Shibata Takahiro, Shimizu Kazuma, Hirano Keita, Nakashima Fumie, Kikuchi Ryosuke, Matsushita Tadashi, Uchida Koji

JOURNAL OF BIOLOGICAL CHEMISTRY 292 巻 ( 20 ) 頁： 8223-8235 2017年5月

Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes

Luis Paula B., Gordon Odaine N., Nakashima Fumie, Joseph Akil I., Shibata Takahiro, Uchida Koji, Schneider Claus

BIOCHEMICAL PHARMACOLOGY 132 巻頁： 143-149 2017年5月

Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E-2 and D-2 by activated human leukocytes

Gimenez-Bastida Juan A., Shibata Takahiro, Uchida Koji, Schneider Claus

FASEB JOURNAL 31 巻 ( 5 ) 頁： 1867-1878 2017年5月

An open sandwich immunoassay for detection of 13(R,S)-hydroxy-9(E),11(E)-octadecadienoic acid 査読有り国際共著

Dong Jinhua, Shichiri Mototada, Chung Chan-I., Shibata Takahiro, Uchida Koji, Hagihara Yoshihisa, Yoshida Yasukazu, Ueda Hiroshi

ANALYST 142 巻 ( 5 ) 頁： 787 - 793 2017年3月

Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein

Kuan Yen-Chou, Hashidume Tsutomu, Shibata Takahiro, Uchida Koji, Shimizu Makoto, Inoue Jun, Sato Ryuichiro

JOURNAL OF BIOLOGICAL CHEMISTRY 292 巻 ( 7 ) 頁： 3016-3028 2017年2月

Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes. 査読有り

Giménez-Bastida, J.A., Shibata, T., Uchida, K., & Schneider, C.

FASEB J. ３２巻頁： 1867-1878 2017年

Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein. 査読有り

Akagawa, M., Minematsu, K., Shibata, T., Kondo, T., Ishii, T., & Uchida K.

Sci Rep. 6 巻頁： 26723 2016年

Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-Gallate: A Potential Mechanism for the Formation of Innate Antigens by Antioxidants 査読有り

PLoS One. 11 巻頁： e0153002 2016年

Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. 査読有り

Shibata, T., Takahashi, K., Matsubara, Y., Inuzuka, E., Nakashima, F., Takahashi, N., Kozai, D., Mori, Y., & Uchida, K.

Sci. Rep. 6 巻頁： 21261 2016年

Identification of C1q as a Binding Protein for Advanced Glycation End Products. 査読有り

Chikazawa, M., Shibata, T., Hatasa, Y., Hirose, S., Otaki, N., Nakashima, F., Ito, M., Machida, S., Maruyama, S., & Uchida, K.

55 巻頁： 435-446 2016年

Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile. 査読有り

Kumagai, T., Usami, H., Matsukawa, N., Nakashima, F., Chikazawa, M., Shibata, T., Noguchi, N., and Uchida, K.

Redox Biol. 4 巻頁： 74-86 2015年

15-Deoxy-Δ12,14-prostaglandin J2 as an electrophilic mediator. 招待有り査読有り

Shibata, T.

Biosci. Biotechnol. Biochem. 79 巻頁： 1044-1049 2015年

Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins. 査読有り

Miyashita, H., Chikazawa, M., Otaki, N., Hioki, Y., Shimozu, Y., Nakashima, F., Shibata, T., Hagihara, Y., Maruyama, S., Matsumi, N., Uchida, K. (2014)

Sci. Rep. 4 巻頁： 5343 2014年

Toll-like receptors as a target of food-derived anti-inflammatory compounds. 査読有り

Shibata, T., Nakashima, F., Honda, K., Lu, Y.J., Kondo, T., Ushida, Y., Aizawa, K., Suganuma, H., Oe, S., Tanaka, H., Takahashi, T., and Uchida, K.

J. Biol. Chem. 289 巻頁： 32757-32772. 2014年

Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigens. 査読有り

1. Chikazawa, M., Otaki, N., Shibata, T., Miyashita, H., Kawai, Y., Maruyama, S., Toyokuni, S., Kitaura, Y., Matsuda, T., and Uchida, K.

J. Biol. Chem. 288 巻頁： 13204-13214 2013年

An apoptosis-associated mammary protein deficiency leads to enhanced production of IgM antibodies against multiple damage-associated molecules. 査読有り

Chikazawa, M., Otaki, N., Shibata, T., Yasueda, T., Matsuda, T., and Uchida, K.

PLoS One 8 巻頁： e68468. 2013年

Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1. 査読有り

5. Kumano-Kuramochi, M., Shimozu, Y., Wakita, C., Ohnishi-Kameyama, M., Shibata, T., Matsunaga, S., Takano-Ishikawa, Y., Watanabe, J., Goto, M., Xie, Q., Komba, S., Uchida, K., and Machida, S

Biochem. J. 442 巻頁： 171-180 2012年2月

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. 査読有り

Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T.

8 巻頁： 714- 724 2012年

Quantitative Analysis of Acrolein-Specific Adducts Generated during Lipid Peroxidation-Modification of Proteins in Vitro. 査読有り

25 巻頁： 1384-1392 2012年

Monoclonal Antibody against Protein-Bound Glutathione: Use of Glutathione Conjugate of Acrolein-Modified Proteins as an Immunogen. 査読有り

Chem. Res. Toxicol. 25 巻頁： 1393-1401 2012年

Constitutive expression of an antioxidant enzyme, glutathione S-transferase P1, during differentiation of human intestinal Caco-2 cells. 査読有り

53 巻頁： 347-356 2012年

Transthiocarbamoylation of proteins by thiolated isothiocyanates 査読有り

Shibata, T., Kimura, Y., Mukai, A., Mori, H., Ito, S., Asaka, Y., Oe, S., Tanaka, H., Takahashi, T., and Uchida, K.

J. Biol. Chem. 頁： in press 2011年

4-Hydroperoxy-2-nonenal is not just an intermediate, but a reactive molecule that covalently modifies proteins to generate unique intramolecular oxidation products. 査読有り

Shimozu, Y., Hirano, K., Shibata, T., Shibata, N., and Uchida, K.

J. Biol. Chem. 286 巻頁： 29313-29324. 2011年

Lipid peroxidation modification of protein generates Nepsilon-(4-oxononanoyl)lysine as a pro-inflammatory ligand. . 査読有り

Shibata, T., Shimozu, Y., Wakita, C., Shibata, N., Kobayashi, M., Machida, S., Kato, R., Itabe, H., Zhu, X., Sayre, L. M., and Uchida, K.

J. Biol. Chem 286 巻頁： 19943-19957. 2011年

A method for detection of 4-hydroxy-2-nonenal adducts in proteins. 査読有り

Wakita, C., Honda, K., Shibata, T., Akagawa, M., and Uchida, K.

Free Radic. Biol. Med. 51 巻頁： 1-4 2011年

Delta12-Prostaglandin J2 as a Product and Ligand of Human Serum Albumin: Formation of an Unusual Covalent Adduct at His146. 査読有り

Yamaguchi, S., Aldini, G., Ito, S., Morishita, N., Shibata, T., Vistoli, G., Carini, M., Uchida, K.

J. Am. Chem. Soc. 132 巻頁： 824-832 2010年

Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies. 査読有り

Otaki, N., Chikazawa, M., Nagae, R., Shimozu, Y., Shibata, T., Ito, S., Takasaki, Y., Fujii, J., and Uchida K.

J. Biol. Chem. 285 巻頁： 33834-33842 2010年

Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation. 査読有り

Nishida, M., Suda, R., Nagamatsu, Y., Tanabe, S., Onohara, N., Nakaya, M., Kanaho, Y., Shibata, T., Uchida, K., Sumimoto, H., Sato, Y., Kurose, H.

J. Biol. Chem. 285 巻頁： 15268-15277 2010年

Lipid peroxidation generates a body odor component trans-2-nonenal covalently bound to protein in vivo. 査読有り

Ishino, K., Wakita, C., Shibata, T., Toyokuni, S., Machida, S., Matsuda, S., Matsuda, T., Uchida, K.

J. Biol. Chem. 285 巻頁： 15302-15313 2010年

Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-delta12,14-prostaglandin J2. 査読有り

Zhang, H.X., Tanji, K., Yoshida, H., Hayakari, M., Shibata, T., Mori, F., Uchida, K., Wakabayashi, K.

Exp. Neurol. 222 巻頁： 296-303 2010年

Lipid peroxidation generates a body odor component trans-2-nonenal covalently bound to protein in vivo. 査読有り

J. Biol. Chem. ( 285 ) 頁： 15302-15313 2010年

Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy- delta12,14-prostaglandin J2. 査読有り

30) Zhang, H.X., Tanji, K., Yoshida, H., Hayakari, M., Shibata, T., Mori, F., Uchida, K., Wakabayashi, K.

Exp. Neurol. 222 巻頁： 296-303 2010年

Identification of advanced reaction products originating from the initial 4-oxo-2-nonenal-cysteine Michael adducts. 査読有り

Shimozu, Y., Shibata, T., Ojika, M., Uchida, K.

Chem. Res. Toxicol. 22 巻頁： 957-964 2009年

Immunohistochemical Detection of 13(R)-hydroxyoctadecadienoic Acid in Atherosclerotic Plaques of Human Carotid Arteries Using a Novel Specific Antibody. 査読有り

Shibata N, Toi S, Shibata T, Uchida K, Itabe H, Sawada T, Kawamata T, Okada Y, Uchiyama S, Kobayashi M.

Acta Histochem. Cytochem. 42 巻頁： 197-203 2009年

Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein. 査読有り

Wakita, C., Maeshima, T., Yamazaki, A., Shibata, T., Ito, S., Akagawa, M., Ojika, M., Yodoi, J., Uchida, K.

J. Biol. Chem. 284 巻頁： 28810-28822 2009年

15-Deoxy-Delta(12,14)-prostaglandin J2: An Electrophilic Trigger of Cellular Responses. 招待有り査読有り

Uchida, K., & Shibata, T.

Chem. Res. Toxicol. 138-144. 21 巻頁： 138-144 2008年1月

*A food-derived synergist of NGF signaling: Identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction. 査読有り

Shibata T, Nakahara H, Kita N, Matsubara Y, Han C, Morimitsu Y, Iwamoto N, Kumagai Y, Nishida M, Kurose H, Aoki N, Ojika M, Uchida K.

J. Neurochem. 107 巻 ( 5 ) 頁： 1248-1260 2008年

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. 査読有り

Takahashi, N., Mizuno, Y., Kozai, D., Yamamoto, S., Kiyonaka, S., Shibata, T., Uchida, K., and Mori, Y.

Channels (Austin) 2 巻頁： 287-298 2008年

Protein N-Acylation: H2O2-Mediated Covalent Modification of Protein by Lipid Peroxidation-Derived Saturated Aldehydes. 査読有り

Ishino, K., Shibata, T., Ishii, T., Liu, Y. T., Toyokuni, S., Zhu, X., Sayre, L. M., and Uchida, K.

Chem. Res. Toxicol. 21 巻頁： 1261-1270 2008年

Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells. 査読有り

21) Kusano, Y., Horie, S., Shibata, T., Satsu, H., Shimizu, M., Hitomi, E., Nishida, M., Kurose, H., Itoh, K., Kobayashi, A., Yamamoto, M., and Uchida, K.

Biochemistry 47 巻頁： 6169-6177 2008年

Identification of a Serum Component That Regulates Cyclooxygenase-2 Gene Expression in Cooperation with 4-Hydroxy-2-nonenal. 査読有り

Kanayama M, Yamaguchi S, Shibata T, Shibata N, Kobayashi M, Nagai R, Arai H, Takahashi K, Uchida K.

J. Biol. Chem. 282 巻 ( 33 ) 頁： 24166-24174 2007年8月

Granulatoside A, a Starfish Steroid Glycoside, Enhances PC12 Cell Neuritogenesis Induced by Nerve Growth Factor through an Activation of MAP Kinase. 査読有り

Qi J, Han C, Sasayama Y, Nakahara H, Shibata T, Uchida K, Ojika M.

ChemMedChem. 1 巻頁： 1351-4 2007年

Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. 査読有り

Mizutani, N., Sakurai, T., Shibata, T., Uchida, K., Fujita, J., Kawashima, R., Kawamura, Y. I., Toyama-Sorimachi, N., Imai, T., & Dohi, T.

J. Immunol. 179 巻頁： 7478-87 2007年

Protein-bound 4-Hydroxy-2-nonenal: AN ENDOGENOUS TRIGGERING ANTIGEN OF ANTI-DNA RESPONSE. 査読有り

Toyoda K, Nagae R, Akagawa M, Ishino K, Shibata T, Ito S, Shibata N, Yamamoto T, Kobayashi M, Takasaki Y, Matsuda T, Uchida K.

J. Biol. Chem. 282 巻 ( 35 ) 頁： 25769-25778 2007年

Identification of Actin as a 15-Deoxy-Delta(12,14)-prostaglandin J(2) Target in Neuroblastoma Cells: Mass Spectrometric, Computational, and Functional Approaches To Investigate the Effect on Cytoskeletal Derangement. 査読有り

Aldini G, Carini M, Vistoli G, Shibata T, Kusano Y, Gamberoni L, Dalle-Donne I, Milzani A, Uchida K.

Biochemistry 46 巻 ( 10 ) 頁： 2707-2718 2007年

Polymer-Assisted Solution-Phase Synthesis and Neurite-Outgrowth-Promoting Activity of 15-Deoxy- 12,14-PGJ2 Derivatives 査読有り

Tanaka H, Hasegawa T, Kita N, Nakahara H, Shibata T, Oe S, Ojika M, Uchida K, and Takahashi T.

Chemistry-An Asian Journal 1 巻頁： 669-677 2007年

ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. 査読有り

Kobayashi M, Ono H, Mihara K, Tauchi H, Komatsu K, Shibata T, Shimizu H, Uchida K, Yamamoto K.

Genes Cells 11 巻 ( 7 ) 頁： 779-789 2006年7月

Prostaglandins from a zoanthid: Paclitaxel-like neurite-degenerating and microtubule-stabilizating activities. 査読有り

Han C, Qi J, Shi X, Sakagami Y, Shibata T, Uchida K, & Ojika M.

Biosci. Biotechnol. Biochem. 70 巻頁： 706-11 2006年3月

Bispecific abs against modified protein and DNA with oxidized lipids. 査読有り

Akagawa M, Ito S, Toyoda K, Ishii Y, Tatsuda E, Shibata T, Yamaguchi S, Kawai Y, Ishino K, Kishi Y, Adachi T, Tsubata T, Takasaki Y, Hattori N, Matsuda T, Uchida K.

Proc. Natl. Acad. Sci. USA 103 巻頁： 6160-5 2006年

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. 査読有り

Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M.

Mol. Cell. Biol. 26 巻 ( 1 ) 頁： 221-229 2006年

Metal-catalyzed oxidation of protein-bound dopamine. 査読有り

Akagawa M, Ishii Y, Ishii T, Shibata T, Yotsu-Yamashita M, Suyama K, Uchida K.

Biochemistry 45 巻 ( 50 ) 頁： 15120-8 2006年

Ebselen, a Seleno-organic Antioxidant, as an Electrophile 査読有り

Sakurai, T., Kanayama, M., Shibata, T., Itoh, K., Kobayashi, A., Yamamoto, M., & Uchida, K.

Chem. Res. Toxicol. 19 巻頁： 1196-204 2006年

Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. 査読有り

Hosoya T, Maruyama A, Kang MI, Kawatani Y, Shibata T, Uchida K, Itoh K, & Yamamoto M.

J. Biol. Chem. 280 巻頁： 27244-27250 2005年

「J2型プロスタグランジン研究の現状」

柴田貴広、内田浩二

日本生化学会誌「生化学」 77 巻頁： 1189-1192 2005年

「野菜由来イソチオシアネートによる神経細胞分化誘導」

柴田貴広、中原寛子、内田浩二

食品工業 48 巻頁： 63-67 2005年

「プロスタグランジンJ2の化学と生物　-多様な生理活性とその分子過程-」

柴田貴広、内田浩二

日本農芸化学会誌　「化学と生物」 43 巻 ( 1 ) 頁： 20-27 2005年

*Identification of a lipid peroxidation product as a potential trigger of the p53 pathway. 査読有り

Shibata T, Iio K, Kawai Y, Shibata N, Kawaguchi M, Toi S, Kobayashi M, Kobayashi M, Yamamoto K, & Uchida K.

J. Biol. Chem. 281 巻頁： 1196-1204 2005年

Transcription Factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-delta12,14-prostaglandin J2. 査読有り

Itoh K, Mochizuki M, Ishii Y, Ishii T, Shibata T, Kawamoto Y, Kelly V, Sekizawa K, Uchida K, & Yamamoto M.

Mol. Cell. Biol. 24 巻頁： 36-45 2004年

Structural basis of protein-bound endogenous aldehydes : Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct. 査読有り

Hashimoto M, Shibata T, Wasada H, Toyokuni S, & Uchida K.

J. Biol. Chem 278 巻頁： 5044-51 2003年

An endogenous electrophile that modulates the regulatory mechanism of protein turnover. 査読有り

Biochemistry 42 巻頁： 13960-13968 2003年

Thioredoxin as a molecular target of cyclopentenone prostaglandins. 査読有り

Shibata T, Yamada T, Ishii T, Kumazawa S, Nakamura H, Masutani H, Yodoi J, & Uchida K

J. Biol.Chem 278 巻頁： 26046-54 2003年

15-Deoxy-delta12,14-prostaglandin J2: The endogenous electrophile that induces neuronal apoptosis 査読有り

Kondo M, Shibata T, Kumagai T, Osawa T, Shibata N, Kobayashi M, Sasaki S, Iwata M, Noguchi N, and Uchida K.

Proc. Natl. Acad. Sci. USA 99 巻 ( 11 ) 頁： 7367-7372 2002年

15-Deoxy-delta12,14-prostaglandin J2: A PROSTAGLANDIN D2 METABOLITE GENERATED DURING INFLAMMATORY PROCESSES 査読有り

Shibata T, Kondo M, Osawa T, Shibata N, Kobayashi M, & Uchida K.

J. Biol. Chem. 277 巻 ( 12 ) 頁： 10459-10466 2002年

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