Faculty Profiles - SHIBATA, Takahiro

Papers - SHIBATA, Takahiro

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Isocitrate dehydrogenase 1 upregulation in urinary extracellular vesicles from proximal tubules of type 2 diabetic rats Reviewed International journal

Sei, H; Hirade, N; Kamiya, K; Nakashima, F; Yoshitake, J; Kano, K; Mishiro-Sato, E; Kikuchi, R; Uchida, K; Shibata, T

FASEB JOURNAL Vol. 38 ( 10 ) page： e23688 2024.5

Inhibition of Lysosomal Cathepsin A and Neuraminidase 1 Interaction by Anti-Obesity Cyclic Peptide Reviewed

Sun, YT; Dakiiwa, A; Zhang, MH; Shibata, T; Kita, M

CHEMISTRY-A EUROPEAN JOURNAL Vol. 30 ( 56 ) page： e202402049 2024.10

Seabuckthorn (Hippophae rhamnoides, L.) pulp oil prevents ultraviolet-induced damage in human fibroblasts Reviewed

Okamoto, T; Nakashima, F; Shibata, T; Mori, D

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY Vol. 88 ( 8 ) page： 948 - 955 2024.6

Eriodictyol and thymonin act as GPR35 agonists Reviewed International journal

Nakashima Fumie, Loh Wei Qi, Wakabayashi Mayuka, Shimomura Sayako, Hattori Hiroyuki, Kita Masaki, Inoue Asuka, Uchida Koji, Shibata Takahiro

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 2023.9

The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis Reviewed International coauthorship International journal

Nakashima Fumie, Gimenez-Bastida Juan A., Luis Paula B., Presley Sai H., Boer Robert E., Chiusa Manuel, Shibata Takahiro, Sulikowski Gary A., Pozzi Ambra, Schneider Claus

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 299 ( 4 ) page： 103050 2023.4

Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis Reviewed International coauthorship International journal

Okuda Kosaku, Nakahara Kengo, Ito Akihiro, Iijima Yuta, Nomura Ryosuke, Kumar Ashutosh, Fujikawa Kana, Adachi Kazuya, Shimada Yuki, Fujio Satoshi, Yamamoto Reina, Takasugi Nobumasa, Onuma Kunishige, Osaki Mitsuhiko, Okada Futoshi, Ukegawa Taichi, Takeuchi Yasuo, Yasui Norihisa, Yamashita Atsuko, Marusawa Hiroyuki, Matsushita Yosuke, Katagiri Toyomasa, Shibata Takahiro, Uchida Koji, Niu Sheng-Yong, Lang Nhi B., Nakamura Tomohiro, Zhang Kam Y. J., Lipton Stuart A., Uehara Takashi

NATURE COMMUNICATIONS Vol. 14 ( 1 ) page： 621 2023.2

Neuritogenic steroid glycosides from crown-of-thorns starfish: Possible involvement of p38 mitogen-activated protein kinase and attenuation of cognitive impairment in senescence-accelerated mice (SAMP8) by peripheral administration Reviewed International coauthorship International journal

Sasayama Yumi, Mamiya Takayoshi, Qi Jianhua, Shibata Takahiro, Uchida Koji, Nabeshima Toshitaka, Ojika Makoto

BIOORGANIC & MEDICINAL CHEMISTRY Vol. 78 page： 117144 2023.1

Metabolomics of small extracellular vesicles derived from isocitrate dehydrogenase 1-mutant HCT116 cells collected by semi-automated size exclusion chromatography Invited Reviewed International journal

Hayasaka Ryosuke, Tabata Sho, Hasebe Masako, Ikeda Satsuki, Hikita Tomoya, Oneyama Chitose, Yoshitake Jun, Onoshima Daisuke, Takahashi Kumiko, Shibata Takahiro, Uchida Koji, Baba Yoshinobu, Soga Tomoyoshi, Tomita Masaru, Hirayama Akiyoshi

FRONTIERS IN MOLECULAR BIOSCIENCES Vol. 9 page： 1049402 2023.1

Tetrachloroaurate (III)–induced oxidation increases nonthermal plasma-induced aldehydes Invited Reviewed

3. Okazaki Y, Yoshitake J, Ito N, Sasaki K, Tanaka H, Hori M, Shibata T, Toyokuni S.

Adv. Redox Res. Vol. 9 page： 10004 2023

Molecular networking-based lipid profiling and multi-omics approaches reveal new contributions of functional vanilloids to gut microbiota and lipometabolism changes Reviewed International journal

Hattori Hiroyuki, Moriyama Akihiro, Ohno Tomoki, Shibata Takahiro, Iwahashi Hitoshi, Mitsunaga Tohru

FOOD CHEMISTRY: MOLECULAR SCIENCES Vol. 5 page： 100123 2022.12

Autoxidation of ascorbate mediates lysine N-pyrrolation Reviewed International journal

Yoshitake Jun, Shibata Takahiro, Chikazawa Miho, Uchida Koji

FREE RADICAL RESEARCH Vol. 56 ( 11-12 ) page： 749 - 759 2022.12

Rapid Isolation of Extracellular Vesicles Using a Hydrophilic Porous Silica Gel-Based Size-Exclusion Chromatography Column Reviewed

Yoshitake Jun, Azami Mayuko, Sei Haruka, Onoshima Daisuke, Takahashi Kumiko, Hirayama Akiyoshi, Uchida Koji, Baba Yoshinobu, Shibata Takahiro

ANALYTICAL CHEMISTRY Vol. 94 ( 40 ) page： 13676 - 13681 2022.9

Histone functions as a cell-surface receptor for AGEs Reviewed

Itakura Masanori, Yamaguchi Kosuke, Kitazawa Roma, Lim Sei-Young, Anan Yusuke, Yoshitake Jun, Shibata Takahiro, Negishi Lumi, Sugawa Hikari, Nagai Ryoji, Uchida Koji

NATURE COMMUNICATIONS Vol. 13 ( 1 ) page： 2974 2022.5

Redox-dependent internalization of the purinergic P2Y(6) receptor limits colitis progression Reviewed International coauthorship

Nishiyama Kazuhiro, Nishimura Akiyuki, Shimoda Kakeru, Tanaka Tomohiro, Kato Yuri, Shibata Takahiro, Tanaka Hiroshi, Kurose Hitoshi, Azuma Yasu-Taka, Ihara Hideshi, Kumagai Yoshito, Akaike Takaaki, Eaton Philip, Uchida Koji, Nishida Motohiro

SCIENCE SIGNALING Vol. 15 ( 716 ) page： eabj0644 2022.1

Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution Reviewed

Kinoshita Remi, Kozaki Ikko, Shimizu Kazunori, Shibata Takahiro, Ochiai Akihito, Honda Hiroyuki

ACS OMEGA Vol. 6 ( 46 ) page： 31244 - 31252 2021.11

Low-molecular-weight whey proteins promote collagen production in dermal fibroblasts via the TGF-beta receptor/Smad pathway Reviewed

Katayoshi Takeshi, Kusano Yuri, Shibata Takahiro, Uchida Koji, Tsuji-Naito Kentaro

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY Vol. 85 ( 11 ) page： 2232 - 2240 2021.11

Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified Reviewed

Tanaka Hiromasa, Hosoi Yugo, Ishikawa Kenji, Yoshitake Jun, Shibata Takahiro, Uchida Koji, Hashizume Hiroshi, Mizuno Masaaki, Okazaki Yasumasa, Toyokuni Shinya, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru

SCIENTIFIC REPORTS Vol. 11 ( 1 ) page： 18488 2021.9

Oxidative deamination of lysine residues by polyphenols generates an equilibrium of aldehyde and 2-piperidinol products Reviewed

Yamaguchi Kosuke, Itakura Masanori, Kitazawa Roma, Lim Sei-Young, Nagata Koji, Shibata Takahiro, Akagawa Mitsugu, Uchida Koji

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 297 ( 3 ) page： 101035 2021.9

6-Paradol Acts as a Potential Anti-obesity Vanilloid from Grains of Paradise Reviewed International journal

Hattori Hiroyuki, Mori Takashi, Shibata Takahiro, Kita Masaki, Mitsunaga Tohru

MOLECULAR NUTRITION & FOOD RESEARCH Vol. 65 ( 16 ) page： e2100185 2021.8

Identification of biosynthetic intermediates for the mating hormone alpha 2 of the plant pathogen Phytophthora Reviewed

Ariyoshi Suguru, Imazu Yusuke, Ohguri Ryuji, Katsuta Ryo, Yajima Arata, Shibata Takahiro, Ojika Makoto

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY Vol. 85 ( 8 ) page： 1802 - 1808 2021.7

Sodium sulfite causes gastric mucosal cell death by inducing oxidative stress Reviewed

Oshimo Moeri, Nakashima Fumie, Kai Kenji, Matsui Hirofumi, Shibata Takahiro, Akagawa Mitsugu

FREE RADICAL RESEARCH Vol. 55 ( 6 ) page： 731 - 743 2021.6

Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution Reviewed

Yoshioka Keitaro, Yamashita Haruki, Shimizu Kazunori, Shimomura Sayako, Shibata Takahiro, Miyazaki Jun-ichi, Honda Hiroyuki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 550 page： 177 - 183 2021.4

Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor

Hasegawa Kana, Kuwata Keiko, Yoshitake Jun, Shimomura Sayako, Uchida Koji, Shibata Takahiro

FEBS JOURNAL Vol. 288 ( 6 ) page： 1906 - 1917 2021.3

Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution. Invited Reviewed

Yoshioka K, Yamashita H, Shimizu K, Shimomura S, Shibata T, Miyazaki JI, Honda H.

Biochem. Biophys. Res. Commun. Vol. 550 page： 177 - 183 2021

PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates

Kamata Shotaro, Oyama Takuji, Saito Kenta, Honda Akihiro, Yamamoto Yume, Suda Keisuke, Ishikawa Ryo, Itoh Toshimasa, Watanabe Yasuo, Shibata Takahiro, Uchida Koji, Suematsu Makoto, Ishii Isao

ISCIENCE Vol. 23 ( 11 ) page： 101727 2020.11

Acrolein in cigarette smoke attenuates the innate immune responses mediated by surfactant protein D

Takamiya Rina, Takahashi Motoko, Maeno Toshitaka, Saito Atsushi, Kato Masaki, Shibata Takahiro, Uchida Koji, Ariki Shigeru, Nakano Miyako

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS Vol. 1864 ( 11 ) page： 129699 2020.11

Acyl-CoA dehydrogenase long chain (ACADL) is a target protein of stylissatin A, an anti-inflammatory cyclic heptapeptide

Zhang Menghua, Sunaba Taiki, Sun Yiting, Shibata Takahiro, Sasaki Kazunori, Isoda Hiroko, Kigoshi Hideo, Kita Masaki

JOURNAL OF ANTIBIOTICS Vol. 73 ( 8 ) page： 589 - 592 2020.8

Isolation and structure-activity relationship studies of jacaranones: Anti-inflammatory quinoids from the Cuban endemic plant Jacaranda arborea (Bignoniaceae)

Hirukawa Minako, Zhang Menghua, Echenique-Diaz Lazaro M., Mizota Koji, Ohdachi Satoshi D., Begue-Quiala Gerardo, Delgado-Labanino Jorge L., Gamez-Diez Jorgelino, Alvarez-Lemus Jose, Galano Machado Leandro, Suarez Nunez Miguel, Shibata Takahiro, Kigoshi Hideo, Kita Masaki

Tetrahedron Letters Vol. 61 ( 26 ) 2020.6

Glycolaldehyde is an endogenous source of lysine N-pyrrolation

Chikazawa Miho, Yoshitake Jun, Lim Sei-Young, Iwata Shiori, Negishi Lumi, Shibata Takahiro, Uchida Koji

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 295 ( 22 ) page： 7697 - 7709 2020.5

Quantitative analysis of oxidized vitamin B1 metabolites generated by hypochlorous acid

Sasatsuki Hitoshi, Nakazaki Atsuo, Uchida Koji, Shibata Takahiro

FREE RADICAL BIOLOGY AND MEDICINE Vol. 152 page： 197 - 206 2020.5

Relationship among structure, cytotoxicity, and Michael acceptor reactivity of quinocidin

Nakagawa Yu, Sawaki Yuki, Miyanishi Wataru, Shimomura Sayako, Shibata Takahiro, Ojika Makoto

BIOORGANIC & MEDICINAL CHEMISTRY Vol. 28 ( 4 ) page： 115308 2020.2

A unique mechanism for thiolation of serum albumins by disulphide molecules

Nakashima Fumie, Shibata Takahiro, Uchida Koji

JOURNAL OF BIOCHEMISTRY Vol. 167 ( 2 ) page： 165 - 171 2020.2

Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B

Nho Cong Luong, Abiko Yumi, Shibata Takahiro, Uchida Koji, Warabi Eiji, Suzuki Midori, Noguchi Takuya, Matsuzawa Atsushi, Kumagai Yoshito

JOURNAL OF TOXICOLOGICAL SCIENCES Vol. 45 ( 6 ) page： 349 - 363 2020

Protein adductomics: A comprehensive analysis of protein modifications by electrophiles.

Shibata T, Uchida K

Free radical biology & medicine Vol. 144 page： 218 - 222 2019.11

Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal(ONE) in preeclamptic placentas. Reviewed International coauthorship International journal

Free radical biology & medicine Vol. 141 page： 416 - 425 2019.9

A Dual Perspective of the Action of Lysine on Soybean Oil Oxidation Process Obtained by Combining <sup>1</sup>H NMR and LC-MS: Antioxidant Effect and Generation of Lysine-Aldehyde Adducts. Reviewed International coauthorship International journal

Antioxidants (Basel, Switzerland) Vol. 8 ( 9 ) 2019.9

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

Suzuki Takafumi, Muramatsu Aki, Saito Ryota, Iso Tatsuro, Shibata Takahiro, Kuwata Keiko, Kawaguchi Shin-ichi, Iwawaki Takao, Adachi Saki, Suda Hiromi, Morita Masanobu, Uchida Koji, Baird Liam, Yamamoto Masayuki

CELL REPORTS Vol. 28 ( 3 ) page： 746 - + 2019.7

Apolipoprotein E binds to and reduces serum levels of DNA-mimicking, pyrrolated proteins

Hirose Sayumi, Hioki Yusuke, Miyashita Hiroaki, Hirade Naoya, Yoshitake Jun, Shibata Takahiro, Kikuchi Ryosuke, Matsushita Tadashi, Chikazawa Miho, Itakura Masanori, Zhang Mimin, Nagata Koji, Uchida Koji

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 294 ( 28 ) page： 11035 - 11045 2019.7

2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct. Reviewed International journal

Yoshitake J, Shibata T, Shimayama C, Uchida K

Redox biology Vol. 23 page： 101115 2019.5

2-Oxo-histidine-containing dipeptides are functional oxidation products

Ihara Hideshi, Kakihana Yuki, Yamakage Akane, Kai Kenji, Shibata Takahiro, Nishida Motohiro, Yamada Ken-ichi, Uchida Koji

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 294 ( 4 ) page： 1279-1289 2019.1

Diosgenin Supplementation Prevents Lipid Accumulation and Induces Skeletal Muscle-Fiber Hypertrophy in Rats

Kusano Yuri, Tsujihara Nobuko, Masui Hironori, Shibata Takahiro, Uchida Koji, Takeuchi Wakako

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY Vol. 65 ( 5 ) page： 421 - 429 2019

Development of a novel monoclonal antibody against 4-hydroxy-2E,6Z-dodecadienal (4-HDDE)-protein adducts: Immunochemical application in quantitative and qualitative analyses of lipid peroxidation in vitro and ex vivo

Uchida Koji, Shibata Takahiro, Toyokuni Shinya, Daniel Bareket, Zarkovic Kamelija, Zarkovic Neven, Sasson Shlomo

FREE RADICAL BIOLOGY AND MEDICINE Vol. 124 page： 12-20 2018.8

Structural and functional insights into S-thiolation of human serum albumins

Nakashima Fumie, Shibata Takahiro, Kamiya Kohei, Yoshitake Jun, Kikuchi Ryosuke, Matsushita Tadashi, Ishii Isao, Gimenez-Bastida Juan A., Schneider Claus, Uchida Koji

SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 932 2018.1

Detection and quantification of 2-oxo-histidine-containing dipeptides

Ihara Hideshi, Kakihana Yuki, Yamakage Akane, Shibata Takahiro, Uchida Koji

FREE RADICAL BIOLOGY AND MEDICINE Vol. 112 page： 26 - 27 2017.11

Lipid radicals cause light-induced retinal degeneration Reviewed International journal

Enoki Masataka, Shinto Saki, Matsuoka Yuta, Otsuka Ayasa, Kaidzu Sachiko, Tanito Masaki, Shibata Takahiro, Uchida Koji, Ohira Akihiro, Yamatoa Mayumi, Yamada Ken-ichi

CHEMICAL COMMUNICATIONS Vol. 53 ( 79 ) page： 10922 - 10925 2017.10

Identification of Polyphenol-Specific Innate Epitopes That Originated from a Resveratrol Analogue

Furuhashi Mai, Hatasa Yukinori, Kawarnura Sae, Shibata Takahiro, Akagawa Mitsugu, Uchida Koji

BIOCHEMISTRY Vol. 56 ( 35 ) page： 4701-4712 2017.9

De Novo Synthesis of Possible Candidates for the Inagami-Tamura Endogenous Digitalis-like Factor

Nakazaki Atsuo, Hashimoto Keiko, Ikeda Ai, Shibata Takahiro, Nishikawa Toshio

JOURNAL OF ORGANIC CHEMISTRY Vol. 82 ( 17 ) page： 9097-9111 2017.9

Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke

Takamiya Rina, Uchida Koji, Shibata Takahiro, Maeno Toshitaka, Kato Masaki, Yamaguchi Yoshiki, Ariki Shigeru, Hasegawa Yoshihiro, Saito Atsushi, Miwa Soichi, Takahashi Hiroki, Akaike Takaaki, Kuroki Yoshio, Takahashi Motoko

SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 8304 2017.8

Adductome-based identification of biomarkers for lipid peroxidation

Shibata Takahiro, Shimizu Kazuma, Hirano Keita, Nakashima Fumie, Kikuchi Ryosuke, Matsushita Tadashi, Uchida Koji

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 292 ( 20 ) page： 8223-8235 2017.5

Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes

Luis Paula B., Gordon Odaine N., Nakashima Fumie, Joseph Akil I., Shibata Takahiro, Uchida Koji, Schneider Claus

BIOCHEMICAL PHARMACOLOGY Vol. 132 page： 143-149 2017.5

Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E-2 and D-2 by activated human leukocytes

Gimenez-Bastida Juan A., Shibata Takahiro, Uchida Koji, Schneider Claus

FASEB JOURNAL Vol. 31 ( 5 ) page： 1867-1878 2017.5

An open sandwich immunoassay for detection of 13(R,S)-hydroxy-9(E),11(E)-octadecadienoic acid Reviewed International coauthorship

Dong Jinhua, Shichiri Mototada, Chung Chan-I., Shibata Takahiro, Uchida Koji, Hagihara Yoshihisa, Yoshida Yasukazu, Ueda Hiroshi

ANALYST Vol. 142 ( 5 ) page： 787 - 793 2017.3

Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein

Kuan Yen-Chou, Hashidume Tsutomu, Shibata Takahiro, Uchida Koji, Shimizu Makoto, Inoue Jun, Sato Ryuichiro

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 292 ( 7 ) page： 3016-3028 2017.2

Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes. Reviewed

Giménez-Bastida, J.A., Shibata, T., Uchida, K., & Schneider, C.

FASEB J. Vol. ３２ page： 1867-1878 2017

Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein. Reviewed

Akagawa, M., Minematsu, K., Shibata, T., Kondo, T., Ishii, T., & Uchida K.

Sci Rep. Vol. 6 page： 26723 2016

Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-Gallate: A Potential Mechanism for the Formation of Innate Antigens by Antioxidants Reviewed

PLoS One. Vol. 11 page： e0153002 2016

Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. Reviewed

Shibata, T., Takahashi, K., Matsubara, Y., Inuzuka, E., Nakashima, F., Takahashi, N., Kozai, D., Mori, Y., & Uchida, K.

Sci. Rep. Vol. 6 page： 21261 2016

Identification of C1q as a Binding Protein for Advanced Glycation End Products. Reviewed

Chikazawa, M., Shibata, T., Hatasa, Y., Hirose, S., Otaki, N., Nakashima, F., Ito, M., Machida, S., Maruyama, S., & Uchida, K.

Vol. 55 page： 435-446 2016

Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile. Reviewed

Kumagai, T., Usami, H., Matsukawa, N., Nakashima, F., Chikazawa, M., Shibata, T., Noguchi, N., and Uchida, K.

Redox Biol. Vol. 4 page： 74-86 2015

15-Deoxy-Δ12,14-prostaglandin J2 as an electrophilic mediator. Invited Reviewed

Shibata, T.

Biosci. Biotechnol. Biochem. Vol. 79 page： 1044-1049 2015

Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins. Reviewed

Miyashita, H., Chikazawa, M., Otaki, N., Hioki, Y., Shimozu, Y., Nakashima, F., Shibata, T., Hagihara, Y., Maruyama, S., Matsumi, N., Uchida, K. (2014)

Sci. Rep. Vol. 4 page： 5343 2014

Toll-like receptors as a target of food-derived anti-inflammatory compounds. Reviewed

Shibata, T., Nakashima, F., Honda, K., Lu, Y.J., Kondo, T., Ushida, Y., Aizawa, K., Suganuma, H., Oe, S., Tanaka, H., Takahashi, T., and Uchida, K.

J. Biol. Chem. Vol. 289 page： 32757-32772. 2014

An apoptosis-associated mammary protein deficiency leads to enhanced production of IgM antibodies against multiple damage-associated molecules. Reviewed

Chikazawa, M., Otaki, N., Shibata, T., Yasueda, T., Matsuda, T., and Uchida, K.

PLoS One Vol. 8 page： e68468. 2013

Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigens. Reviewed

1. Chikazawa, M., Otaki, N., Shibata, T., Miyashita, H., Kawai, Y., Maruyama, S., Toyokuni, S., Kitaura, Y., Matsuda, T., and Uchida, K.

J. Biol. Chem. Vol. 288 page： 13204-13214 2013

Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1. Reviewed

5. Kumano-Kuramochi, M., Shimozu, Y., Wakita, C., Ohnishi-Kameyama, M., Shibata, T., Matsunaga, S., Takano-Ishikawa, Y., Watanabe, J., Goto, M., Xie, Q., Komba, S., Uchida, K., and Machida, S

Biochem. J. Vol. 442 page： 171-180 2012.2

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. Reviewed

Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T.

Vol. 8 page： 714- 724 2012

Quantitative Analysis of Acrolein-Specific Adducts Generated during Lipid Peroxidation-Modification of Proteins in Vitro. Reviewed

Vol. 25 page： 1384-1392 2012

Monoclonal Antibody against Protein-Bound Glutathione: Use of Glutathione Conjugate of Acrolein-Modified Proteins as an Immunogen. Reviewed

Chem. Res. Toxicol. Vol. 25 page： 1393-1401 2012

Constitutive expression of an antioxidant enzyme, glutathione S-transferase P1, during differentiation of human intestinal Caco-2 cells. Reviewed

Kusano Y, Horie S, Morishita N, Shibata T, Uchida K.

Free Radic. Biol. Med. Vol. 53 page： 347-356 2012

Transthiocarbamoylation of proteins by thiolated isothiocyanates Reviewed

Shibata, T., Kimura, Y., Mukai, A., Mori, H., Ito, S., Asaka, Y., Oe, S., Tanaka, H., Takahashi, T., and Uchida, K.

J. Biol. Chem. page： in press 2011

4-Hydroperoxy-2-nonenal is not just an intermediate, but a reactive molecule that covalently modifies proteins to generate unique intramolecular oxidation products. Reviewed

Shimozu, Y., Hirano, K., Shibata, T., Shibata, N., and Uchida, K.

J. Biol. Chem. Vol. 286 page： 29313-29324. 2011

Lipid peroxidation modification of protein generates Nepsilon-(4-oxononanoyl)lysine as a pro-inflammatory ligand. . Reviewed

Shibata, T., Shimozu, Y., Wakita, C., Shibata, N., Kobayashi, M., Machida, S., Kato, R., Itabe, H., Zhu, X., Sayre, L. M., and Uchida, K.

J. Biol. Chem Vol. 286 page： 19943-19957. 2011

A method for detection of 4-hydroxy-2-nonenal adducts in proteins. Reviewed

Wakita, C., Honda, K., Shibata, T., Akagawa, M., and Uchida, K.

Free Radic. Biol. Med. Vol. 51 page： 1-4 2011

Delta12-Prostaglandin J2 as a Product and Ligand of Human Serum Albumin: Formation of an Unusual Covalent Adduct at His146. Reviewed

Yamaguchi, S., Aldini, G., Ito, S., Morishita, N., Shibata, T., Vistoli, G., Carini, M., Uchida, K.

J. Am. Chem. Soc. Vol. 132 page： 824-832 2010

Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies. Reviewed

Otaki, N., Chikazawa, M., Nagae, R., Shimozu, Y., Shibata, T., Ito, S., Takasaki, Y., Fujii, J., and Uchida K.

J. Biol. Chem. Vol. 285 page： 33834-33842 2010

Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation. Reviewed

Nishida, M., Suda, R., Nagamatsu, Y., Tanabe, S., Onohara, N., Nakaya, M., Kanaho, Y., Shibata, T., Uchida, K., Sumimoto, H., Sato, Y., Kurose, H.

J. Biol. Chem. Vol. 285 page： 15268-15277 2010

Lipid peroxidation generates a body odor component trans-2-nonenal covalently bound to protein in vivo. Reviewed

Ishino, K., Wakita, C., Shibata, T., Toyokuni, S., Machida, S., Matsuda, S., Matsuda, T., Uchida, K.

J. Biol. Chem. Vol. 285 page： 15302-15313 2010

Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-delta12,14-prostaglandin J2. Reviewed

Zhang, H.X., Tanji, K., Yoshida, H., Hayakari, M., Shibata, T., Mori, F., Uchida, K., Wakabayashi, K.

Exp. Neurol. Vol. 222 page： 296-303 2010

Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy- delta12,14-prostaglandin J2. Reviewed

30) Zhang, H.X., Tanji, K., Yoshida, H., Hayakari, M., Shibata, T., Mori, F., Uchida, K., Wakabayashi, K.

Exp. Neurol. Vol. 222 page： 296-303 2010

Lipid peroxidation generates a body odor component trans-2-nonenal covalently bound to protein in vivo. Reviewed

J. Biol. Chem. ( 285 ) page： 15302-15313 2010

Identification of advanced reaction products originating from the initial 4-oxo-2-nonenal-cysteine Michael adducts. Reviewed

Shimozu, Y., Shibata, T., Ojika, M., Uchida, K.

Chem. Res. Toxicol. Vol. 22 page： 957-964 2009

Immunohistochemical Detection of 13(R)-hydroxyoctadecadienoic Acid in Atherosclerotic Plaques of Human Carotid Arteries Using a Novel Specific Antibody. Reviewed

Shibata N, Toi S, Shibata T, Uchida K, Itabe H, Sawada T, Kawamata T, Okada Y, Uchiyama S, Kobayashi M.

Acta Histochem. Cytochem. Vol. 42 page： 197-203 2009

Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein. Reviewed

Wakita, C., Maeshima, T., Yamazaki, A., Shibata, T., Ito, S., Akagawa, M., Ojika, M., Yodoi, J., Uchida, K.

J. Biol. Chem. Vol. 284 page： 28810-28822 2009

15-Deoxy-Delta(12,14)-prostaglandin J2: An Electrophilic Trigger of Cellular Responses. Invited Reviewed

Uchida, K., & Shibata, T.

Chem. Res. Toxicol. 138-144. Vol. 21 page： 138-144 2008.1

*A food-derived synergist of NGF signaling: Identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction. Reviewed

Shibata T, Nakahara H, Kita N, Matsubara Y, Han C, Morimitsu Y, Iwamoto N, Kumagai Y, Nishida M, Kurose H, Aoki N, Ojika M, Uchida K.

J. Neurochem. Vol. 107 ( 5 ) page： 1248-1260 2008

Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Reviewed

Takahashi, N., Mizuno, Y., Kozai, D., Yamamoto, S., Kiyonaka, S., Shibata, T., Uchida, K., and Mori, Y.

Channels (Austin) Vol. 2 page： 287-298 2008

Protein N-Acylation: H2O2-Mediated Covalent Modification of Protein by Lipid Peroxidation-Derived Saturated Aldehydes. Reviewed

Ishino, K., Shibata, T., Ishii, T., Liu, Y. T., Toyokuni, S., Zhu, X., Sayre, L. M., and Uchida, K.

Chem. Res. Toxicol. Vol. 21 page： 1261-1270 2008

Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells. Reviewed

21) Kusano, Y., Horie, S., Shibata, T., Satsu, H., Shimizu, M., Hitomi, E., Nishida, M., Kurose, H., Itoh, K., Kobayashi, A., Yamamoto, M., and Uchida, K.

Biochemistry Vol. 47 page： 6169-6177 2008

Identification of a Serum Component That Regulates Cyclooxygenase-2 Gene Expression in Cooperation with 4-Hydroxy-2-nonenal. Reviewed

Kanayama M, Yamaguchi S, Shibata T, Shibata N, Kobayashi M, Nagai R, Arai H, Takahashi K, Uchida K.

J. Biol. Chem. Vol. 282 ( 33 ) page： 24166-24174 2007.8

Granulatoside A, a Starfish Steroid Glycoside, Enhances PC12 Cell Neuritogenesis Induced by Nerve Growth Factor through an Activation of MAP Kinase. Reviewed

Qi J, Han C, Sasayama Y, Nakahara H, Shibata T, Uchida K, Ojika M.

ChemMedChem. Vol. 1 page： 1351-4 2007

Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. Reviewed

Mizutani, N., Sakurai, T., Shibata, T., Uchida, K., Fujita, J., Kawashima, R., Kawamura, Y. I., Toyama-Sorimachi, N., Imai, T., & Dohi, T.

J. Immunol. Vol. 179 page： 7478-87 2007

Protein-bound 4-Hydroxy-2-nonenal: AN ENDOGENOUS TRIGGERING ANTIGEN OF ANTI-DNA RESPONSE. Reviewed

Toyoda K, Nagae R, Akagawa M, Ishino K, Shibata T, Ito S, Shibata N, Yamamoto T, Kobayashi M, Takasaki Y, Matsuda T, Uchida K.

J. Biol. Chem. Vol. 282 ( 35 ) page： 25769-25778 2007

Identification of Actin as a 15-Deoxy-Delta(12,14)-prostaglandin J(2) Target in Neuroblastoma Cells: Mass Spectrometric, Computational, and Functional Approaches To Investigate the Effect on Cytoskeletal Derangement. Reviewed

Aldini G, Carini M, Vistoli G, Shibata T, Kusano Y, Gamberoni L, Dalle-Donne I, Milzani A, Uchida K.

Biochemistry Vol. 46 ( 10 ) page： 2707-2718 2007

Polymer-Assisted Solution-Phase Synthesis and Neurite-Outgrowth-Promoting Activity of 15-Deoxy- 12,14-PGJ2 Derivatives Reviewed

Tanaka H, Hasegawa T, Kita N, Nakahara H, Shibata T, Oe S, Ojika M, Uchida K, and Takahashi T.

Chemistry-An Asian Journal Vol. 1 page： 669-677 2007

ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. Reviewed

Kobayashi M, Ono H, Mihara K, Tauchi H, Komatsu K, Shibata T, Shimizu H, Uchida K, Yamamoto K.

Genes Cells Vol. 11 ( 7 ) page： 779-789 2006.7

Prostaglandins from a zoanthid: Paclitaxel-like neurite-degenerating and microtubule-stabilizating activities. Reviewed

Han C, Qi J, Shi X, Sakagami Y, Shibata T, Uchida K, & Ojika M.

Biosci. Biotechnol. Biochem. Vol. 70 page： 706-11 2006.3

Bispecific abs against modified protein and DNA with oxidized lipids. Reviewed

Akagawa M, Ito S, Toyoda K, Ishii Y, Tatsuda E, Shibata T, Yamaguchi S, Kawai Y, Ishino K, Kishi Y, Adachi T, Tsubata T, Takasaki Y, Hattori N, Matsuda T, Uchida K.

Proc. Natl. Acad. Sci. USA Vol. 103 page： 6160-5 2006

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Reviewed

Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M.

Mol. Cell. Biol. Vol. 26 ( 1 ) page： 221-229 2006

Metal-catalyzed oxidation of protein-bound dopamine. Reviewed

Akagawa M, Ishii Y, Ishii T, Shibata T, Yotsu-Yamashita M, Suyama K, Uchida K.

Biochemistry Vol. 45 ( 50 ) page： 15120-8 2006

Ebselen, a Seleno-organic Antioxidant, as an Electrophile Reviewed

Sakurai, T., Kanayama, M., Shibata, T., Itoh, K., Kobayashi, A., Yamamoto, M., & Uchida, K.

Chem. Res. Toxicol. Vol. 19 page： 1196-204 2006

Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. Reviewed

Hosoya T, Maruyama A, Kang MI, Kawatani Y, Shibata T, Uchida K, Itoh K, & Yamamoto M.

J. Biol. Chem. Vol. 280 page： 27244-27250 2005

「J2型プロスタグランジン研究の現状」

柴田貴広、内田浩二

日本生化学会誌「生化学」 Vol. 77 page： 1189-1192 2005

「野菜由来イソチオシアネートによる神経細胞分化誘導」

柴田貴広、中原寛子、内田浩二

食品工業 Vol. 48 page： 63-67 2005

「プロスタグランジンJ2の化学と生物　-多様な生理活性とその分子過程-」

柴田貴広、内田浩二

日本農芸化学会誌　「化学と生物」 Vol. 43 ( 1 ) page： 20-27 2005

*Identification of a lipid peroxidation product as a potential trigger of the p53 pathway. Reviewed

Shibata T, Iio K, Kawai Y, Shibata N, Kawaguchi M, Toi S, Kobayashi M, Kobayashi M, Yamamoto K, & Uchida K.

J. Biol. Chem. Vol. 281 page： 1196-1204 2005

Transcription Factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-delta12,14-prostaglandin J2. Reviewed

Itoh K, Mochizuki M, Ishii Y, Ishii T, Shibata T, Kawamoto Y, Kelly V, Sekizawa K, Uchida K, & Yamamoto M.

Mol. Cell. Biol. Vol. 24 page： 36-45 2004

Structural basis of protein-bound endogenous aldehydes : Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct. Reviewed

Hashimoto M, Shibata T, Wasada H, Toyokuni S, & Uchida K.

J. Biol. Chem Vol. 278 page： 5044-51 2003

An endogenous electrophile that modulates the regulatory mechanism of protein turnover. Reviewed

Biochemistry Vol. 42 page： 13960-13968 2003

Thioredoxin as a molecular target of cyclopentenone prostaglandins. Reviewed

Shibata T, Yamada T, Ishii T, Kumazawa S, Nakamura H, Masutani H, Yodoi J, & Uchida K

J. Biol.Chem Vol. 278 page： 26046-54 2003

15-Deoxy-delta12,14-prostaglandin J2: The endogenous electrophile that induces neuronal apoptosis Reviewed

Kondo M, Shibata T, Kumagai T, Osawa T, Shibata N, Kobayashi M, Sasaki S, Iwata M, Noguchi N, and Uchida K.

Proc. Natl. Acad. Sci. USA Vol. 99 ( 11 ) page： 7367-7372 2002

15-Deoxy-delta12,14-prostaglandin J2: A PROSTAGLANDIN D2 METABOLITE GENERATED DURING INFLAMMATORY PROCESSES Reviewed

Shibata T, Kondo M, Osawa T, Shibata N, Kobayashi M, & Uchida K.

J. Biol. Chem. Vol. 277 ( 12 ) page： 10459-10466 2002

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