Papers - SHIBATA, Takahiro
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A missense mutation in acyl-CoA synthetase ACSL4 reveals essential residues for catalytic activity in ferroptosis. Reviewed Open Access
Sei H, Ando H, Nakashima F, Takahara T, Kita M, Yamada KI, Uchida K, Shibata T
The Journal of Biological Chemistry Vol. 302 ( 3 ) page： 111232 2026.2
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Structural and Functional Basis of G Protein-Coupled Receptor 35 Activation by Pyrroloquinoline Quinone. Reviewed
Ando H, Kanamori A, Wakabayashi M, Nakashima F, Sei H, Hattori H, Kita M, Inoue A, Murakami A, Akagawa M, Uchida K, Shibata T
Biochemistry Vol. 64 ( 24 ) page： 4758 - 4767 2025.11
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Dietary anthocyanidin pelargonidin activates G protein-coupled receptor 35. Reviewed Open Access
Nakashima F, Shimomura S, Wakabayashi M, Loh WQ, Ando H, Sei H, Hattori H, Utomo DH, Kita M, Inoue A, Uchida K, Shibata T
The FEBS journal Vol. 293 page： 1386 - 1399 2026.3
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Isocitrate dehydrogenase 1 upregulation in urinary extracellular vesicles from proximal tubules of type 2 diabetic rats Reviewed International journal Open Access
Sei, H; Hirade, N; Kamiya, K; Nakashima, F; Yoshitake, J; Kano, K; Mishiro-Sato, E; Kikuchi, R; Uchida, K; Shibata, T
FASEB JOURNAL Vol. 38 ( 10 ) page： e23688 2024.5
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Adductome-based identification of lysine mono-methylation as a key post-translational protein modification in autoimmune diseases. Reviewed International journal Open Access
Yamaguchi K, Hu YY, Kawajiri K, Itakura M, Nakashima F, Shibata T, Uchida K
The Journal of biological chemistry page： 110684 2025.9
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Effect of 1-Kestose on Lipid Metabolism in a High-Fat-Diet Rat Model Reviewed International journal
Kuramitsu, K; Kubo, M; Cindy, F; Shibata, T; Kadota, Y; Kitaura, Y
NUTRIENTS Vol. 17 ( 8 ) 2025.4
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GABA promotes myoblast fusion and prevents TNF-α-induced muscle protein degradation in C2C12 cells. Reviewed Open Access
Kusano Y, Bando H, Uyama M, Miyamura K, Miyake T, Shibata T.
Vol. 31 ( 6 ) page： 515 - 523 2025
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Inhibition of Lysosomal Cathepsin A and Neuraminidase 1 Interaction by Anti-Obesity Cyclic Peptide Reviewed
Sun, YT; Dakiiwa, A; Zhang, MH; Shibata, T; Kita, M
CHEMISTRY-A EUROPEAN JOURNAL Vol. 30 ( 56 ) page： e202402049 2024.10
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Okamoto, T; Nakashima, F; Shibata, T; Mori, D
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY Vol. 88 ( 8 ) page： 948 - 955 2024.6
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Tetrachloroaurate (III)-induced oxidation increases nonthermal plasma-induced aldehydes Reviewed International journal Open Access
Okazaki, Y; Yoshitake, J; Ito, N; Sasaki, K; Tanaka, H; Hori, M; Shibata, T; Toyokuni, S
ADVANCES IN REDOX RESEARCH Vol. 9 2023.12
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Eriodictyol and thymonin act as GPR35 agonists Reviewed International journal
Nakashima Fumie, Loh Wei Qi, Wakabayashi Mayuka, Shimomura Sayako, Hattori Hiroyuki, Kita Masaki, Inoue Asuka, Uchida Koji, Shibata Takahiro
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 2023.9
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The 5-lipoxygenase/cyclooxygenase-2 cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis Reviewed International coauthorship International journal Open Access
Nakashima Fumie, Gimenez-Bastida Juan A., Luis Paula B., Presley Sai H., Boer Robert E., Chiusa Manuel, Shibata Takahiro, Sulikowski Gary A., Pozzi Ambra, Schneider Claus
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 299 ( 4 ) page： 103050 2023.4
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Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis Reviewed International coauthorship International journal Open Access
Okuda Kosaku, Nakahara Kengo, Ito Akihiro, Iijima Yuta, Nomura Ryosuke, Kumar Ashutosh, Fujikawa Kana, Adachi Kazuya, Shimada Yuki, Fujio Satoshi, Yamamoto Reina, Takasugi Nobumasa, Onuma Kunishige, Osaki Mitsuhiko, Okada Futoshi, Ukegawa Taichi, Takeuchi Yasuo, Yasui Norihisa, Yamashita Atsuko, Marusawa Hiroyuki, Matsushita Yosuke, Katagiri Toyomasa, Shibata Takahiro, Uchida Koji, Niu Sheng-Yong, Lang Nhi B., Nakamura Tomohiro, Zhang Kam Y. J., Lipton Stuart A., Uehara Takashi
NATURE COMMUNICATIONS Vol. 14 ( 1 ) page： 621 2023.2
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Neuritogenic steroid glycosides from crown-of-thorns starfish: Possible involvement of p38 mitogen-activated protein kinase and attenuation of cognitive impairment in senescence-accelerated mice (SAMP8) by peripheral administration Reviewed International coauthorship International journal
Sasayama Yumi, Mamiya Takayoshi, Qi Jianhua, Shibata Takahiro, Uchida Koji, Nabeshima Toshitaka, Ojika Makoto
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 78 page： 117144 2023.1
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Metabolomics of small extracellular vesicles derived from isocitrate dehydrogenase 1-mutant HCT116 cells collected by semi-automated size exclusion chromatography Invited Reviewed International journal Open Access
Hayasaka Ryosuke, Tabata Sho, Hasebe Masako, Ikeda Satsuki, Hikita Tomoya, Oneyama Chitose, Yoshitake Jun, Onoshima Daisuke, Takahashi Kumiko, Shibata Takahiro, Uchida Koji, Baba Yoshinobu, Soga Tomoyoshi, Tomita Masaru, Hirayama Akiyoshi
FRONTIERS IN MOLECULAR BIOSCIENCES Vol. 9 page： 1049402 2023.1
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Tetrachloroaurate (III)–induced oxidation increases nonthermal plasma-induced aldehydes Invited Reviewed
3. Okazaki Y, Yoshitake J, Ito N, Sasaki K, Tanaka H, Hori M, Shibata T, Toyokuni S.
Adv. Redox Res. Vol. 9 page： 10004 2023
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Molecular networking-based lipid profiling and multi-omics approaches reveal new contributions of functional vanilloids to gut microbiota and lipometabolism changes Reviewed International journal Open Access
Hattori Hiroyuki, Moriyama Akihiro, Ohno Tomoki, Shibata Takahiro, Iwahashi Hitoshi, Mitsunaga Tohru
FOOD CHEMISTRY: MOLECULAR SCIENCES Vol. 5 page： 100123 2022.12
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Autoxidation of ascorbate mediates lysine N-pyrrolation Reviewed International journal
Yoshitake Jun, Shibata Takahiro, Chikazawa Miho, Uchida Koji
FREE RADICAL RESEARCH Vol. 56 ( 11-12 ) page： 749 - 759 2022.12
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Rapid Isolation of Extracellular Vesicles Using a Hydrophilic Porous Silica Gel-Based Size-Exclusion Chromatography Column Reviewed Open Access
Yoshitake Jun, Azami Mayuko, Sei Haruka, Onoshima Daisuke, Takahashi Kumiko, Hirayama Akiyoshi, Uchida Koji, Baba Yoshinobu, Shibata Takahiro
ANALYTICAL CHEMISTRY Vol. 94 ( 40 ) page： 13676 - 13681 2022.9
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Histone functions as a cell-surface receptor for AGEs Reviewed Open Access
Itakura Masanori, Yamaguchi Kosuke, Kitazawa Roma, Lim Sei-Young, Anan Yusuke, Yoshitake Jun, Shibata Takahiro, Negishi Lumi, Sugawa Hikari, Nagai Ryoji, Uchida Koji
NATURE COMMUNICATIONS Vol. 13 ( 1 ) page： 2974 2022.5
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Redox-dependent internalization of the purinergic P2Y(6) receptor limits colitis progression Reviewed International coauthorship
Nishiyama Kazuhiro, Nishimura Akiyuki, Shimoda Kakeru, Tanaka Tomohiro, Kato Yuri, Shibata Takahiro, Tanaka Hiroshi, Kurose Hitoshi, Azuma Yasu-Taka, Ihara Hideshi, Kumagai Yoshito, Akaike Takaaki, Eaton Philip, Uchida Koji, Nishida Motohiro
SCIENCE SIGNALING Vol. 15 ( 716 ) page： eabj0644 2022.1
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Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution Reviewed Open Access
Kinoshita Remi, Kozaki Ikko, Shimizu Kazunori, Shibata Takahiro, Ochiai Akihito, Honda Hiroyuki
ACS OMEGA Vol. 6 ( 46 ) page： 31244 - 31252 2021.11
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Low-molecular-weight whey proteins promote collagen production in dermal fibroblasts via the TGF-beta receptor/Smad pathway Reviewed
Katayoshi Takeshi, Kusano Yuri, Shibata Takahiro, Uchida Koji, Tsuji-Naito Kentaro
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY Vol. 85 ( 11 ) page： 2232 - 2240 2021.11
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Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified Reviewed Open Access
Tanaka Hiromasa, Hosoi Yugo, Ishikawa Kenji, Yoshitake Jun, Shibata Takahiro, Uchida Koji, Hashizume Hiroshi, Mizuno Masaaki, Okazaki Yasumasa, Toyokuni Shinya, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru
SCIENTIFIC REPORTS Vol. 11 ( 1 ) page： 18488 2021.9
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Oxidative deamination of lysine residues by polyphenols generates an equilibrium of aldehyde and 2-piperidinol products Reviewed Open Access
Yamaguchi Kosuke, Itakura Masanori, Kitazawa Roma, Lim Sei-Young, Nagata Koji, Shibata Takahiro, Akagawa Mitsugu, Uchida Koji
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 297 ( 3 ) page： 101035 2021.9
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6-Paradol Acts as a Potential Anti-obesity Vanilloid from Grains of Paradise Reviewed International journal
Hattori Hiroyuki, Mori Takashi, Shibata Takahiro, Kita Masaki, Mitsunaga Tohru
MOLECULAR NUTRITION & FOOD RESEARCH Vol. 65 ( 16 ) page： e2100185 2021.8
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Identification of biosynthetic intermediates for the mating hormone alpha 2 of the plant pathogen Phytophthora Reviewed Open Access
Ariyoshi Suguru, Imazu Yusuke, Ohguri Ryuji, Katsuta Ryo, Yajima Arata, Shibata Takahiro, Ojika Makoto
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY Vol. 85 ( 8 ) page： 1802 - 1808 2021.7
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Sodium sulfite causes gastric mucosal cell death by inducing oxidative stress Reviewed
Oshimo Moeri, Nakashima Fumie, Kai Kenji, Matsui Hirofumi, Shibata Takahiro, Akagawa Mitsugu
FREE RADICAL RESEARCH Vol. 55 ( 6 ) page： 731 - 743 2021.6
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Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution Reviewed
Yoshioka Keitaro, Yamashita Haruki, Shimizu Kazunori, Shimomura Sayako, Shibata Takahiro, Miyazaki Jun-ichi, Honda Hiroyuki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 550 page： 177 - 183 2021.4
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Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor Open Access
Hasegawa Kana, Kuwata Keiko, Yoshitake Jun, Shimomura Sayako, Uchida Koji, Shibata Takahiro
FEBS JOURNAL Vol. 288 ( 6 ) page： 1906 - 1917 2021.3
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Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution. Invited Reviewed
Yoshioka K, Yamashita H, Shimizu K, Shimomura S, Shibata T, Miyazaki JI, Honda H.
Biochem. Biophys. Res. Commun. Vol. 550 page： 177 - 183 2021
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PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates Open Access
Kamata Shotaro, Oyama Takuji, Saito Kenta, Honda Akihiro, Yamamoto Yume, Suda Keisuke, Ishikawa Ryo, Itoh Toshimasa, Watanabe Yasuo, Shibata Takahiro, Uchida Koji, Suematsu Makoto, Ishii Isao
ISCIENCE Vol. 23 ( 11 ) page： 101727 2020.11
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Acrolein in cigarette smoke attenuates the innate immune responses mediated by surfactant protein D
Takamiya Rina, Takahashi Motoko, Maeno Toshitaka, Saito Atsushi, Kato Masaki, Shibata Takahiro, Uchida Koji, Ariki Shigeru, Nakano Miyako
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS Vol. 1864 ( 11 ) page： 129699 2020.11
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Acyl-CoA dehydrogenase long chain (ACADL) is a target protein of stylissatin A, an anti-inflammatory cyclic heptapeptide
Zhang Menghua, Sunaba Taiki, Sun Yiting, Shibata Takahiro, Sasaki Kazunori, Isoda Hiroko, Kigoshi Hideo, Kita Masaki
JOURNAL OF ANTIBIOTICS Vol. 73 ( 8 ) page： 589 - 592 2020.8
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Isolation and structure-activity relationship studies of jacaranones: Anti-inflammatory quinoids from the Cuban endemic plant Jacaranda arborea (Bignoniaceae)
Hirukawa Minako, Zhang Menghua, Echenique-Diaz Lazaro M., Mizota Koji, Ohdachi Satoshi D., Begue-Quiala Gerardo, Delgado-Labanino Jorge L., Gamez-Diez Jorgelino, Alvarez-Lemus Jose, Galano Machado Leandro, Suarez Nunez Miguel, Shibata Takahiro, Kigoshi Hideo, Kita Masaki
Tetrahedron Letters Vol. 61 ( 26 ) 2020.6
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Glycolaldehyde is an endogenous source of lysine N-pyrrolation Open Access
Chikazawa Miho, Yoshitake Jun, Lim Sei-Young, Iwata Shiori, Negishi Lumi, Shibata Takahiro, Uchida Koji
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 295 ( 22 ) page： 7697 - 7709 2020.5
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Quantitative analysis of oxidized vitamin B1 metabolites generated by hypochlorous acid
Sasatsuki Hitoshi, Nakazaki Atsuo, Uchida Koji, Shibata Takahiro
FREE RADICAL BIOLOGY AND MEDICINE Vol. 152 page： 197 - 206 2020.5
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Relationship among structure, cytotoxicity, and Michael acceptor reactivity of quinocidin Open Access
Nakagawa Yu, Sawaki Yuki, Miyanishi Wataru, Shimomura Sayako, Shibata Takahiro, Ojika Makoto
BIOORGANIC & MEDICINAL CHEMISTRY Vol. 28 ( 4 ) page： 115308 2020.2
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A unique mechanism for thiolation of serum albumins by disulphide molecules Open Access
Nakashima Fumie, Shibata Takahiro, Uchida Koji
JOURNAL OF BIOCHEMISTRY Vol. 167 ( 2 ) page： 165 - 171 2020.2
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Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B Open Access
Nho Cong Luong, Abiko Yumi, Shibata Takahiro, Uchida Koji, Warabi Eiji, Suzuki Midori, Noguchi Takuya, Matsuzawa Atsushi, Kumagai Yoshito
JOURNAL OF TOXICOLOGICAL SCIENCES Vol. 45 ( 6 ) page： 349 - 363 2020
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Protein adductomics: A comprehensive analysis of protein modifications by electrophiles. Open Access
Shibata T, Uchida K
Free radical biology & medicine Vol. 144 page： 218 - 222 2019.11
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Modification of endothelial nitric oxide synthase by 4-oxo-2(E)-nonenal(ONE) in preeclamptic placentas. Reviewed International coauthorship International journal Open Access
Free radical biology & medicine Vol. 141 page： 416 - 425 2019.9
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A Dual Perspective of the Action of Lysine on Soybean Oil Oxidation Process Obtained by Combining <sup>1</sup>H NMR and LC-MS: Antioxidant Effect and Generation of Lysine-Aldehyde Adducts. Reviewed International coauthorship International journal Open Access
Antioxidants (Basel, Switzerland) Vol. 8 ( 9 ) 2019.9
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Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1 Open Access
Suzuki Takafumi, Muramatsu Aki, Saito Ryota, Iso Tatsuro, Shibata Takahiro, Kuwata Keiko, Kawaguchi Shin-ichi, Iwawaki Takao, Adachi Saki, Suda Hiromi, Morita Masanobu, Uchida Koji, Baird Liam, Yamamoto Masayuki
CELL REPORTS Vol. 28 ( 3 ) page： 746 - + 2019.7
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Apolipoprotein E binds to and reduces serum levels of DNA-mimicking, pyrrolated proteins Open Access
Hirose Sayumi, Hioki Yusuke, Miyashita Hiroaki, Hirade Naoya, Yoshitake Jun, Shibata Takahiro, Kikuchi Ryosuke, Matsushita Tadashi, Chikazawa Miho, Itakura Masanori, Zhang Mimin, Nagata Koji, Uchida Koji
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 294 ( 28 ) page： 11035 - 11045 2019.7
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2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct. Reviewed International journal Open Access
Yoshitake J, Shibata T, Shimayama C, Uchida K
Redox biology Vol. 23 page： 101115 2019.5
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2-Oxo-histidine-containing dipeptides are functional oxidation products Open Access
Ihara Hideshi, Kakihana Yuki, Yamakage Akane, Kai Kenji, Shibata Takahiro, Nishida Motohiro, Yamada Ken-ichi, Uchida Koji
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 294 ( 4 ) page： 1279-1289 2019.1
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Diosgenin Supplementation Prevents Lipid Accumulation and Induces Skeletal Muscle-Fiber Hypertrophy in Rats Open Access
Kusano Yuri, Tsujihara Nobuko, Masui Hironori, Shibata Takahiro, Uchida Koji, Takeuchi Wakako
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY Vol. 65 ( 5 ) page： 421 - 429 2019
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Development of a novel monoclonal antibody against 4-hydroxy-2E,6Z-dodecadienal (4-HDDE)-protein adducts: Immunochemical application in quantitative and qualitative analyses of lipid peroxidation in vitro and ex vivo
Uchida Koji, Shibata Takahiro, Toyokuni Shinya, Daniel Bareket, Zarkovic Kamelija, Zarkovic Neven, Sasson Shlomo
FREE RADICAL BIOLOGY AND MEDICINE Vol. 124 page： 12-20 2018.8
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Structural and functional insights into S-thiolation of human serum albumins Open Access
Nakashima Fumie, Shibata Takahiro, Kamiya Kohei, Yoshitake Jun, Kikuchi Ryosuke, Matsushita Tadashi, Ishii Isao, Gimenez-Bastida Juan A., Schneider Claus, Uchida Koji
SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 932 2018.1
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Detection and quantification of 2-oxo-histidine-containing dipeptides
Ihara Hideshi, Kakihana Yuki, Yamakage Akane, Shibata Takahiro, Uchida Koji
FREE RADICAL BIOLOGY AND MEDICINE Vol. 112 page： 26 - 27 2017.11
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Lipid radicals cause light-induced retinal degeneration Reviewed International journal
Enoki Masataka, Shinto Saki, Matsuoka Yuta, Otsuka Ayasa, Kaidzu Sachiko, Tanito Masaki, Shibata Takahiro, Uchida Koji, Ohira Akihiro, Yamatoa Mayumi, Yamada Ken-ichi
CHEMICAL COMMUNICATIONS Vol. 53 ( 79 ) page： 10922 - 10925 2017.10
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Identification of Polyphenol-Specific Innate Epitopes That Originated from a Resveratrol Analogue
Furuhashi Mai, Hatasa Yukinori, Kawarnura Sae, Shibata Takahiro, Akagawa Mitsugu, Uchida Koji
BIOCHEMISTRY Vol. 56 ( 35 ) page： 4701-4712 2017.9
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De Novo Synthesis of Possible Candidates for the Inagami-Tamura Endogenous Digitalis-like Factor Open Access
Nakazaki Atsuo, Hashimoto Keiko, Ikeda Ai, Shibata Takahiro, Nishikawa Toshio
JOURNAL OF ORGANIC CHEMISTRY Vol. 82 ( 17 ) page： 9097-9111 2017.9
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Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke Open Access
Takamiya Rina, Uchida Koji, Shibata Takahiro, Maeno Toshitaka, Kato Masaki, Yamaguchi Yoshiki, Ariki Shigeru, Hasegawa Yoshihiro, Saito Atsushi, Miwa Soichi, Takahashi Hiroki, Akaike Takaaki, Kuroki Yoshio, Takahashi Motoko
SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 8304 2017.8
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Adductome-based identification of biomarkers for lipid peroxidation Open Access
Shibata Takahiro, Shimizu Kazuma, Hirano Keita, Nakashima Fumie, Kikuchi Ryosuke, Matsushita Tadashi, Uchida Koji
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 292 ( 20 ) page： 8223-8235 2017.5
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Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes Open Access
Luis Paula B., Gordon Odaine N., Nakashima Fumie, Joseph Akil I., Shibata Takahiro, Uchida Koji, Schneider Claus
BIOCHEMICAL PHARMACOLOGY Vol. 132 page： 143-149 2017.5
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Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E-2 and D-2 by activated human leukocytes Open Access
Gimenez-Bastida Juan A., Shibata Takahiro, Uchida Koji, Schneider Claus
FASEB JOURNAL Vol. 31 ( 5 ) page： 1867-1878 2017.5
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An open sandwich immunoassay for detection of 13(R,S)-hydroxy-9(E),11(E)-octadecadienoic acid Reviewed International coauthorship
Dong Jinhua, Shichiri Mototada, Chung Chan-I., Shibata Takahiro, Uchida Koji, Hagihara Yoshihisa, Yoshida Yasukazu, Ueda Hiroshi
ANALYST Vol. 142 ( 5 ) page： 787 - 793 2017.3
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Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein Open Access
Kuan Yen-Chou, Hashidume Tsutomu, Shibata Takahiro, Uchida Koji, Shimizu Makoto, Inoue Jun, Sato Ryuichiro
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 292 ( 7 ) page： 3016-3028 2017.2
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Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of hemiketals E2 and D2 by activated human leukocytes. Reviewed Open Access
Giménez-Bastida, J.A., Shibata, T., Uchida, K., & Schneider, C.
FASEB J. Vol. ３２ page： 1867-1878 2017
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Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein. Reviewed Open Access
Akagawa, M., Minematsu, K., Shibata, T., Kondo, T., Ishii, T., & Uchida K.
Sci Rep. Vol. 6 page： 26723 2016
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Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-Gallate: A Potential Mechanism for the Formation of Innate Antigens by Antioxidants Reviewed Open Access
PLoS One. Vol. 11 page： e0153002 2016
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Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. Reviewed Open Access
Shibata, T., Takahashi, K., Matsubara, Y., Inuzuka, E., Nakashima, F., Takahashi, N., Kozai, D., Mori, Y., & Uchida, K.
Sci. Rep. Vol. 6 page： 21261 2016
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Identification of C1q as a Binding Protein for Advanced Glycation End Products. Reviewed
Chikazawa, M., Shibata, T., Hatasa, Y., Hirose, S., Otaki, N., Nakashima, F., Ito, M., Machida, S., Maruyama, S., & Uchida, K.
Vol. 55 page： 435-446 2016
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Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile. Reviewed Open Access
Kumagai, T., Usami, H., Matsukawa, N., Nakashima, F., Chikazawa, M., Shibata, T., Noguchi, N., and Uchida, K.
Redox Biol. Vol. 4 page： 74-86 2015
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15-Deoxy-Δ12,14-prostaglandin J2 as an electrophilic mediator. Invited Reviewed
Shibata, T.
Biosci. Biotechnol. Biochem. Vol. 79 page： 1044-1049 2015
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Toll-like receptors as a target of food-derived anti-inflammatory compounds. Reviewed Open Access
Shibata, T., Nakashima, F., Honda, K., Lu, Y.J., Kondo, T., Ushida, Y., Aizawa, K., Suganuma, H., Oe, S., Tanaka, H., Takahashi, T., and Uchida, K.
J. Biol. Chem. Vol. 289 page： 32757-32772. 2014
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Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins. Reviewed Open Access
Miyashita, H., Chikazawa, M., Otaki, N., Hioki, Y., Shimozu, Y., Nakashima, F., Shibata, T., Hagihara, Y., Maruyama, S., Matsumi, N., Uchida, K. (2014)
Sci. Rep. Vol. 4 page： 5343 2014
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Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigens. Reviewed
1. Chikazawa, M., Otaki, N., Shibata, T., Miyashita, H., Kawai, Y., Maruyama, S., Toyokuni, S., Kitaura, Y., Matsuda, T., and Uchida, K.
J. Biol. Chem. Vol. 288 page： 13204-13214 2013
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An apoptosis-associated mammary protein deficiency leads to enhanced production of IgM antibodies against multiple damage-associated molecules. Reviewed
Chikazawa, M., Otaki, N., Shibata, T., Yasueda, T., Matsuda, T., and Uchida, K.
PLoS One Vol. 8 page： e68468. 2013
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Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1. Reviewed
5. Kumano-Kuramochi, M., Shimozu, Y., Wakita, C., Ohnishi-Kameyama, M., Shibata, T., Matsunaga, S., Takano-Ishikawa, Y., Watanabe, J., Goto, M., Xie, Q., Komba, S., Uchida, K., and Machida, S
Biochem. J. Vol. 442 page： 171-180 2012.2
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Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. Reviewed Open Access
Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T.
Vol. 8 page： 714- 724 2012
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Quantitative Analysis of Acrolein-Specific Adducts Generated during Lipid Peroxidation-Modification of Proteins in Vitro. Reviewed
Vol. 25 page： 1384-1392 2012
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Monoclonal Antibody against Protein-Bound Glutathione: Use of Glutathione Conjugate of Acrolein-Modified Proteins as an Immunogen. Reviewed
Chem. Res. Toxicol. Vol. 25 page： 1393-1401 2012
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Constitutive expression of an antioxidant enzyme, glutathione S-transferase P1, during differentiation of human intestinal Caco-2 cells. Reviewed
Kusano Y, Horie S, Morishita N, Shibata T, Uchida K.
Free Radic. Biol. Med. Vol. 53 page： 347-356 2012
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Transthiocarbamoylation of proteins by thiolated isothiocyanates Reviewed
Shibata, T., Kimura, Y., Mukai, A., Mori, H., Ito, S., Asaka, Y., Oe, S., Tanaka, H., Takahashi, T., and Uchida, K.
J. Biol. Chem. page： in press 2011
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4-Hydroperoxy-2-nonenal is not just an intermediate, but a reactive molecule that covalently modifies proteins to generate unique intramolecular oxidation products. Reviewed Open Access
Shimozu, Y., Hirano, K., Shibata, T., Shibata, N., and Uchida, K.
J. Biol. Chem. Vol. 286 page： 29313-29324. 2011
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Lipid peroxidation modification of protein generates Nepsilon-(4-oxononanoyl)lysine as a pro-inflammatory ligand. . Reviewed
Shibata, T., Shimozu, Y., Wakita, C., Shibata, N., Kobayashi, M., Machida, S., Kato, R., Itabe, H., Zhu, X., Sayre, L. M., and Uchida, K.
J. Biol. Chem Vol. 286 page： 19943-19957. 2011
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A method for detection of 4-hydroxy-2-nonenal adducts in proteins. Reviewed
Wakita, C., Honda, K., Shibata, T., Akagawa, M., and Uchida, K.
Free Radic. Biol. Med. Vol. 51 page： 1-4 2011
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Delta12-Prostaglandin J2 as a Product and Ligand of Human Serum Albumin: Formation of an Unusual Covalent Adduct at His146. Reviewed
Yamaguchi, S., Aldini, G., Ito, S., Morishita, N., Shibata, T., Vistoli, G., Carini, M., Uchida, K.
J. Am. Chem. Soc. Vol. 132 page： 824-832 2010
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Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies. Reviewed
Otaki, N., Chikazawa, M., Nagae, R., Shimozu, Y., Shibata, T., Ito, S., Takasaki, Y., Fujii, J., and Uchida K.
J. Biol. Chem. Vol. 285 page： 33834-33842 2010
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Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation. Reviewed
Nishida, M., Suda, R., Nagamatsu, Y., Tanabe, S., Onohara, N., Nakaya, M., Kanaho, Y., Shibata, T., Uchida, K., Sumimoto, H., Sato, Y., Kurose, H.
J. Biol. Chem. Vol. 285 page： 15268-15277 2010
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Lipid peroxidation generates a body odor component trans-2-nonenal covalently bound to protein in vivo. Reviewed
Ishino, K., Wakita, C., Shibata, T., Toyokuni, S., Machida, S., Matsuda, S., Matsuda, T., Uchida, K.
J. Biol. Chem. Vol. 285 page： 15302-15313 2010
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Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-delta12,14-prostaglandin J2. Reviewed
Zhang, H.X., Tanji, K., Yoshida, H., Hayakari, M., Shibata, T., Mori, F., Uchida, K., Wakabayashi, K.
Exp. Neurol. Vol. 222 page： 296-303 2010
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Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy- delta12,14-prostaglandin J2. Reviewed
30) Zhang, H.X., Tanji, K., Yoshida, H., Hayakari, M., Shibata, T., Mori, F., Uchida, K., Wakabayashi, K.
Exp. Neurol. Vol. 222 page： 296-303 2010
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Lipid peroxidation generates a body odor component trans-2-nonenal covalently bound to protein in vivo. Reviewed
J. Biol. Chem. ( 285 ) page： 15302-15313 2010
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Identification of advanced reaction products originating from the initial 4-oxo-2-nonenal-cysteine Michael adducts. Reviewed
Shimozu, Y., Shibata, T., Ojika, M., Uchida, K.
Chem. Res. Toxicol. Vol. 22 page： 957-964 2009
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Immunohistochemical Detection of 13(R)-hydroxyoctadecadienoic Acid in Atherosclerotic Plaques of Human Carotid Arteries Using a Novel Specific Antibody. Reviewed Open Access
Shibata N, Toi S, Shibata T, Uchida K, Itabe H, Sawada T, Kawamata T, Okada Y, Uchiyama S, Kobayashi M.
Acta Histochem. Cytochem. Vol. 42 page： 197-203 2009
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Stereochemical configuration of 4-hydroxy-2-nonenal-cysteine adducts and their stereoselective formation in a redox-regulated protein. Reviewed
Wakita, C., Maeshima, T., Yamazaki, A., Shibata, T., Ito, S., Akagawa, M., Ojika, M., Yodoi, J., Uchida, K.
J. Biol. Chem. Vol. 284 page： 28810-28822 2009
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15-Deoxy-Delta(12,14)-prostaglandin J2: An Electrophilic Trigger of Cellular Responses. Invited Reviewed
Uchida, K., & Shibata, T.
Chem. Res. Toxicol. 138-144. Vol. 21 page： 138-144 2008.1
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Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells. Reviewed
21) Kusano, Y., Horie, S., Shibata, T., Satsu, H., Shimizu, M., Hitomi, E., Nishida, M., Kurose, H., Itoh, K., Kobayashi, A., Yamamoto, M., and Uchida, K.
Biochemistry Vol. 47 page： 6169-6177 2008
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*A food-derived synergist of NGF signaling: Identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction. Reviewed
Shibata T, Nakahara H, Kita N, Matsubara Y, Han C, Morimitsu Y, Iwamoto N, Kumagai Y, Nishida M, Kurose H, Aoki N, Ojika M, Uchida K.
J. Neurochem. Vol. 107 ( 5 ) page： 1248-1260 2008
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Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators. Reviewed Open Access
Takahashi, N., Mizuno, Y., Kozai, D., Yamamoto, S., Kiyonaka, S., Shibata, T., Uchida, K., and Mori, Y.
Channels (Austin) Vol. 2 page： 287-298 2008
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Protein N-Acylation: H2O2-Mediated Covalent Modification of Protein by Lipid Peroxidation-Derived Saturated Aldehydes. Reviewed
Ishino, K., Shibata, T., Ishii, T., Liu, Y. T., Toyokuni, S., Zhu, X., Sayre, L. M., and Uchida, K.
Chem. Res. Toxicol. Vol. 21 page： 1261-1270 2008
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Identification of a Serum Component That Regulates Cyclooxygenase-2 Gene Expression in Cooperation with 4-Hydroxy-2-nonenal. Reviewed
Kanayama M, Yamaguchi S, Shibata T, Shibata N, Kobayashi M, Nagai R, Arai H, Takahashi K, Uchida K.
J. Biol. Chem. Vol. 282 ( 33 ) page： 24166-24174 2007.8
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Granulatoside A, a Starfish Steroid Glycoside, Enhances PC12 Cell Neuritogenesis Induced by Nerve Growth Factor through an Activation of MAP Kinase. Reviewed
Qi J, Han C, Sasayama Y, Nakahara H, Shibata T, Uchida K, Ojika M.
ChemMedChem. Vol. 1 page： 1351-4 2007
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Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine. Reviewed
Mizutani, N., Sakurai, T., Shibata, T., Uchida, K., Fujita, J., Kawashima, R., Kawamura, Y. I., Toyama-Sorimachi, N., Imai, T., & Dohi, T.
J. Immunol. Vol. 179 page： 7478-87 2007
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Protein-bound 4-Hydroxy-2-nonenal: AN ENDOGENOUS TRIGGERING ANTIGEN OF ANTI-DNA RESPONSE. Reviewed
Toyoda K, Nagae R, Akagawa M, Ishino K, Shibata T, Ito S, Shibata N, Yamamoto T, Kobayashi M, Takasaki Y, Matsuda T, Uchida K.
J. Biol. Chem. Vol. 282 ( 35 ) page： 25769-25778 2007
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Identification of Actin as a 15-Deoxy-Delta(12,14)-prostaglandin J(2) Target in Neuroblastoma Cells: Mass Spectrometric, Computational, and Functional Approaches To Investigate the Effect on Cytoskeletal Derangement. Reviewed
Aldini G, Carini M, Vistoli G, Shibata T, Kusano Y, Gamberoni L, Dalle-Donne I, Milzani A, Uchida K.
Biochemistry Vol. 46 ( 10 ) page： 2707-2718 2007
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Polymer-Assisted Solution-Phase Synthesis and Neurite-Outgrowth-Promoting Activity of 15-Deoxy- 12,14-PGJ2 Derivatives Reviewed
Tanaka H, Hasegawa T, Kita N, Nakahara H, Shibata T, Oe S, Ojika M, Uchida K, and Takahashi T.
Chemistry-An Asian Journal Vol. 1 page： 669-677 2007
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ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. Reviewed Open Access
Kobayashi M, Ono H, Mihara K, Tauchi H, Komatsu K, Shibata T, Shimizu H, Uchida K, Yamamoto K.
Genes Cells Vol. 11 ( 7 ) page： 779-789 2006.7
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Prostaglandins from a zoanthid: Paclitaxel-like neurite-degenerating and microtubule-stabilizating activities. Reviewed Open Access
Han C, Qi J, Shi X, Sakagami Y, Shibata T, Uchida K, & Ojika M.
Biosci. Biotechnol. Biochem. Vol. 70 page： 706-11 2006.3
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Ebselen, a Seleno-organic Antioxidant, as an Electrophile Reviewed
Sakurai, T., Kanayama, M., Shibata, T., Itoh, K., Kobayashi, A., Yamamoto, M., & Uchida, K.
Chem. Res. Toxicol. Vol. 19 page： 1196-204 2006
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Bispecific abs against modified protein and DNA with oxidized lipids. Reviewed
Akagawa M, Ito S, Toyoda K, Ishii Y, Tatsuda E, Shibata T, Yamaguchi S, Kawai Y, Ishino K, Kishi Y, Adachi T, Tsubata T, Takasaki Y, Hattori N, Matsuda T, Uchida K.
Proc. Natl. Acad. Sci. USA Vol. 103 page： 6160-5 2006
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Metal-catalyzed oxidation of protein-bound dopamine. Reviewed
Akagawa M, Ishii Y, Ishii T, Shibata T, Yotsu-Yamashita M, Suyama K, Uchida K.
Biochemistry Vol. 45 ( 50 ) page： 15120-8 2006
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Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Reviewed
Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M.
Mol. Cell. Biol. Vol. 26 ( 1 ) page： 221-229 2006
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*Identification of a lipid peroxidation product as a potential trigger of the p53 pathway. Reviewed Open Access
Shibata T, Iio K, Kawai Y, Shibata N, Kawaguchi M, Toi S, Kobayashi M, Kobayashi M, Yamamoto K, & Uchida K.
J. Biol. Chem. Vol. 281 page： 1196-1204 2005
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Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. Reviewed Open Access
Hosoya T, Maruyama A, Kang MI, Kawatani Y, Shibata T, Uchida K, Itoh K, & Yamamoto M.
J. Biol. Chem. Vol. 280 page： 27244-27250 2005
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「プロスタグランジンJ2の化学と生物 -多様な生理活性とその分子過程-」 Open Access
柴田貴広、内田浩二
日本農芸化学会誌 「化学と生物」 Vol. 43 ( 1 ) page： 20-27 2005
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「J2型プロスタグランジン研究の現状」
柴田貴広、内田浩二
日本生化学会誌「生化学」 Vol. 77 page： 1189-1192 2005
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「野菜由来イソチオシアネートによる神経細胞分化誘導」
柴田貴広、中原寛子、内田浩二
食品工業 Vol. 48 page： 63-67 2005
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Transcription Factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-delta12,14-prostaglandin J2. Reviewed
Itoh K, Mochizuki M, Ishii Y, Ishii T, Shibata T, Kawamoto Y, Kelly V, Sekizawa K, Uchida K, & Yamamoto M.
Mol. Cell. Biol. Vol. 24 page： 36-45 2004
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Structural basis of protein-bound endogenous aldehydes : Chemical and immunochemical characterizations of configurational isomers of a 4-hydroxy-2-nonenal-histidine adduct. Reviewed
Hashimoto M, Shibata T, Wasada H, Toyokuni S, & Uchida K.
J. Biol. Chem Vol. 278 page： 5044-51 2003
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An endogenous electrophile that modulates the regulatory mechanism of protein turnover. Reviewed
Biochemistry Vol. 42 page： 13960-13968 2003
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Thioredoxin as a molecular target of cyclopentenone prostaglandins. Reviewed Open Access
Shibata T, Yamada T, Ishii T, Kumazawa S, Nakamura H, Masutani H, Yodoi J, & Uchida K
J. Biol.Chem Vol. 278 page： 26046-54 2003
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15-Deoxy-delta12,14-prostaglandin J2: The endogenous electrophile that induces neuronal apoptosis Reviewed Open Access
Kondo M, Shibata T, Kumagai T, Osawa T, Shibata N, Kobayashi M, Sasaki S, Iwata M, Noguchi N, and Uchida K.
Proc. Natl. Acad. Sci. USA Vol. 99 ( 11 ) page： 7367-7372 2002
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15-Deoxy-delta12,14-prostaglandin J2: A PROSTAGLANDIN D2 METABOLITE GENERATED DURING INFLAMMATORY PROCESSES Reviewed
Shibata T, Kondo M, Osawa T, Shibata N, Kobayashi M, & Uchida K.
J. Biol. Chem. Vol. 277 ( 12 ) page： 10459-10466 2002