Faculty Profiles - SATO, Chihiro

Papers - SATO, Chihiro

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Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution. Reviewed

Guérardel Y, Chang LY, Fujita A, Coddeville B, Maes E, Sato C, Harduin-Lepers A, Kubokawa K, Kitajima K

Glycobiolgy page： in press 2012

Co-expression of two distinct polysialic acids, α2,8- and α2,9-linked polymers of N-acetylneuraminic acid, in distinct glycoproteins and glycolipids in sea urchin sperm. Reviewed

Vol. 21 page： 1596-1605 2011.12

New function of polysialic acid and its involvement in neural activities

Sato C.

Seikagaku Vol. 83 ( 3 ) page： 189-196 2011.12

Co-expression of two distinct polysialic acids, α2,8- and α2,9-linked polymers of N-acetylneuraminic acid, in distinct glycoproteins and glycolipids in sea urchin sperm. Reviewed

Vol. 21 page： 1596-1605 2011.12

The Roles of Carbohydrate Binding in Cell Adhesion and Inflammation Reviewed

Ken Kitajima, Chihiro Sato

Carbohydrate Recognition: Biological Problems, Methods, and Applications page： 33 - 63 2011.7

New function of polysialic acid and its involvement in neural activities

SATO Chihiro, KITAJIMA Ken

Vol. 83 ( 3 ) page： 189-196 2011.3

ポリシアル酸の新機能と神経形成維持機構 Reviewed

佐藤ちひろ, 北島　健

生化学 Vol. 83 page： 189-196 2011.3

[New function of polysialic acid and its involvement in neural activities].

Sato C, Kitajima K

Seikagaku. The Journal of Japanese Biochemical Society Vol. 83 ( 3 ) page： 189-96 2011.3

New functions of polysialic acid and its relationship to schizophrenia Reviewed

Sato C and Kitajima K

Vol. 23 page： 221-238 2011

Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia Reviewed

Isomura, R., Kitajima, K., and Sato, C.

J. Biol. Chem. Vol. 286 page： 21535-21545 2011

Human KDN (deaminated neuraminic acid) and its elevated expression in cancer cells: Mechanism and significance Reviewed

Sadako Inoue, Ken Kitajima, Chihiro Sato, Shinji Go

Advances in Experimental Medicine and Biology Vol. 705 page： 669 - 78 2011

Language：English Publishing type：Research paper (international conference proceedings)

Sialic acids are a family of nine-carbon carboxylated sugars having a nonulosonate skeletal structure (Fig. 35.1). This structure is uniquely different from that of other sugar units of animal glycans. The most popular sialic acid is N-acetylneuraminic acid (Neu5Ac), which is universally found on cell surface glycocalyx and in secreted glycoproteins of vertebrates and some invertebrates. Sialic acids have low acid-base dissociation constants and give a negative charge on the cell surface under a wide range of physiological pH. In nature, more than 50 kinds of sialic acids are known. Nearly all of them are derived from Neu5Ac by a substitution on the hydroxyl groups (e.g., O-acetyl-Neu5Ac) and/or a hydroxylation of the N-acetyl group (e.g., N-glycolylneuraminic acid, Neu5Gc). Each modified sialic acid has properties different from those of Neu5Ac and is believed to contribute to specific physiological functions. In animal cells, sialic acids are most frequently the terminal sugars of cell surface glycolipids and glycoproteins, and any change that occurs on sialic acids can considerably influence the biological properties of a cell. © 2011 Springer Science+Business Media, LLC.

DOI： 10.1007/978-1-4419-7877-6_35

Web of Science

Scopus

PubMed

Mechanism Regulating Ca2+-dependent Mechanosensory Behaviour in Sea Urchin Spermatozoa Reviewed

Yuka Kambara, Kogiku Shiba, Manabu Yoshida, Chihiro Sato, Ken Kitajima, Chikako Shingyoji

CELL STRUCTURE AND FUNCTION Vol. 36 ( 1 ) page： 69 - 82 2011

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC CELL BIOLOGY

Flagellar movement of the sea urchin sperm is regulated by intracellular Ca2+. Flagellasialin, a polysialic acid-containing glycoprotein, as well as other membrane proteins seems responsible for the Ca2+ control. To elucidate the mechanism of Ca2+ dynamics underlying flagellar movement, we analysed the sperm's mechanosensory behavioural responses by using microtechniques. In sea water containing 10 mM Ca2+, the sperm swim in circular paths. When a mechanical stimulus was applied to the sperm head with a glass microstylus, the sperm showed a series of flagellar responses, consisting of a stoppage of beating (quiescence) and a recovery of swimming in a straight path, followed by swimming in a circular path again; as the result the sperm avoided the obstacle. Ca2+-imaging with Fluo-4 showed that the intracellular Ca2+ was high in the quiescence and gradually decreased after that. The effects of blockers and antibodies against candidate components revealed that the Ca2+ influx was induced by Ca2+ channels and the Ca2+ efflux was induced by a flagellasialin-related Ca2+-efflux system, plasma membrane Ca2+-ATPases and the K+-dependent Na+/Ca2+ exchanger. The results show that the Ca2+-dependent mechanosensory behaviour of the sea urchin sperm is regulated by organized functioning of the membrane environment including the plasma membrane proteins and flagellasialin.

DOI： 10.1247/csf.10020

Mechanism Regulating Ca2+-dependent Mechanosensory Behaviour in Sea Urchin Spermatozoa

Kambara Yuka, Shiba Kogiku, Yoshida Manabu, Sato Chihiro, Kitajima Ken, Shingyoji Chikako

CELL STRUCTURE AND FUNCTION Vol. 36 ( 1 ) page： 69-82 2011

Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia Reviewed

Isomura, R, Kitajima, K, Sato, C

J. Biol. Chem. Vol. 286 page： 21535-21545 2011

New functions of polysialic acid and its relationship to schizophrenia Reviewed

Sato C, Kitajima K

Vol. 23 page： 221-238 2011

Developmental stage-dependent expression of an alpha 2,8-trisialic acid unit on glycoproteins in mouse brain Reviewed

Emi Inoko, Yuji Nishiura, Hiroshi Tanaka, Takashi Takahashi, Koichi Furukawa, Ken Kitajima, Chihiro Sato

GLYCOBIOLOGY Vol. 20 ( 7 ) page： 916 - 28 2010.7

Language：English Publishing type：Research paper (scientific journal) Publisher：OXFORD UNIV PRESS INC

The monoclonal antibody mAb.A2B5 is a marker for the detection of oligodendrocyte progenitor cells that differentiate into type-2 astrocytes and oligodendrocytes. It is also a useful antibody for separating these cells from other lineage populations. The epitope of this antibody is considered to be the gangliosides GT3 and GQ1c. In this study, we sought to define more precisely the structure of the epitope. Accordingly, we chemically synthesized defined oligosialic acid structures linked to phosphatidylethanolamine and bovine serum albumin and used these to determine the antigenic specificity. mAb.A2B5 recognized the Neu5Ac alpha 2 -> 8Neu5Ac alpha 2 -> 8Neu5Ac alpha -> structure on both glycolipids and glycoproteins. We then examined whether the mAb.A2B5 epitope exists on glycoproteins in developing mouse brains. Western blot analyses revealed the expression of four glycoproteins reactive with the mAb.A2B5, and their expression was dependent on the stage of neural development. All the immunoreactivity in these glycoproteins with mAb.A2B5 disappeared after sialidase treatment and were resistant to chloroform/methanol extraction. These epitopes were also detected in brain homogenates from both GD3 synthetase-null and GD3/GD2 synthetase double null mice. These findings show that the alpha 2,8-trisialic acid (triSia) unit recognized by mAb.A2B5 resides not only on gangliosides but also on glycoproteins in developing mouse brain. We postulate that the triSia structure on glycoproteins may be involved in oligodendrocyte differentiation, similar to the case with the alpha 2,8-triSia structure on gangliosides. Real time polymerase chain reaction analysis of the developmental expression of all known ST8Sia genes, which are responsible for the biosynthesis of alpha 2,8-linked Sia residues, showed that ST8Sia III gene expression correlated with expression of the triSia epitope. We suggest that ST8Sia III is the principal sialyltransferase responsible for synthesis of the alpha 2,8-triSia units on glycoproteins.

DOI： 10.1093/glycob/cwq049

Web of Science

Scopus

PubMed

糖鎖と統合失調症 Invited

佐藤ちひろ

生体の科学 Vol. 61 page： 160-166 2010

IgG2 dominancy and carbohydrate recognition specificity of C3H/He mouse antibodies directed to cross-reactive carbohydrate determinants (CCDs) bearing beta-(1,2)-xylose and alpha-(1,3)-fucose. Reviewed

Hino S, Umeda F, Inumaru S, Aoki N, Sato, C., Okajima T, Nadano D, Matsuda T.

Immunol Lett Vol. 133 page： 28-34 2010

Survival signals of hepatic stellate cells in liver regeneration are regulated by glycosylation changes in rat vitronectin, especially decreased sialylation. Reviewed

Sano K, Miyamoto Y, Kawasaki N, Hashii N, Itoh S, Murase M, Date K, Yokoyama M, Sato, C., Kitajima K, Ogawa H.

J Biol Chem Vol. 285 page： 17301-17309 2010

Extensive enrichment of N-glycolylneuraminic acid in extracellular sialoglycoproteins abundantly synthesized and secreted by human cancer cells. Reviewed

Inoue, S., Sato, C. and Kitajima, K

Glycobiology Vol. 20 page： 752-762 2010

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Papers - SATO, Chihiro