研究者詳細 - 佐藤　ちひろ

書籍等出版物 - 佐藤　ちひろ

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Role of Polysialic Acid in Schizophrenia

Sato C., Hane M., Kitajima K.

Comprehensive Glycoscience: Second Edition 2021年6月（ ISBN:9780128222447 ）

Polysialic acid as an integrative decoder in nervous and reproductive systems

Sato C., Kitajima K.

Glycome: The Hidden Code in Biology 2021年4月（ ISBN:9781536194371 ）

記述言語：日本語

In gametes, embryos, and neural cells, huge glycans with >10 kDa are often attached on glycoconjugates. Of those, the polysialic acid (polySia) modifies the neural cell adhesion molecules and other particular proteins, playing multiple roles in regulation of cell surface phenomena. Underlying mechanisms for the polySia-related functions are twofold. One is due to structural diversity of polySia arisen from differences in the Sia species, the inter-residue linkage, and the degree of polymerization (DP). Significance of the DP has been clarified, and not only lectins but also physiologically active molecules recognize the polymerized structures of Sia in a DP-dependent manner to trigger the different downstream signals. The other is based on the repulsive and attractive interactions of polySia with polySia itself and other binding counterpart molecules including BDNF and FGF2. Here we show that, as a code for cell surface event, the polymerized structures of Sia are expressed and interacted with various decoders, such as Siglecs, BDNF, FGF2, and dopamine, which specifically bind each of their diverse structures, diSia, triSia, oligoSia and polySia. Especially, polySia is shown to display repulsive and attractive fields at the same time to implement integrated functions of various related physiologically active molecules.

Scopus

糖鎖生物学 : 生命現象と糖鎖情報

北島健, 佐藤ちひろ, 門松健治, 加藤晃一（担当：共著）

名古屋大学出版会 2020年（ ISBN:9784815809812 ）

ST8 alpha-N-acetyl-neuraminide alpha- 2,8-sialyltransferase 2 (ST8SIA2)

Sato C.

Handbook of Glycosyltransferases and Related Genes, Second Edition 2014年1月（ ISBN:9784431542407, 9784431542391 ）

記述言語：日本語

ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 2 (ST8SIA2) is a member of a family of α2,8-sialyltransferases that transfer sialic acid from CMP-sialic acid onto sialic acid residues of other sialoglycans to generate α2,8-linked sialoglycans. ST8SIA2 is characterized by the ability to synthesize polysialic acid (polySia) structure and can therefore be subclassified as a polysialyltransferase. Both ST8SIA2 and the related polysialyltransferase ST8SIA4 (refer to the Chap. ST8SIA4) are capable of synthesizing extraordinary long polySia chains with degrees of polymerization (DP) of up to 400. ST8SIA2 is a type II transmembrane protein, similar to many other glycosyltransferases, and is composed of 375 amino acids with six N-glycans. This enzyme contains sialyl-motif (SM) L, S, VS, and III domains.

DOI： 10.1007/978-4-431-54240-7_77

Scopus

Polysialic acid

Sato C.

Sialobiology: Structure, Biosynthesis and Function. Sialic Acid Glycoconjugates in Health and Disease 2013年8月（ ISBN:9781608050673 ）

記述言語：日本語

Sialic acids (Sia) are involved in many biological activities and are commonly present as monosialyl residues at the non-reducing terminal end of glycoconjugates. Occasionally, polymerized structures in the form of disialic acid (diSia), oligosialic acid (oligoSia), and polysialic acid (polySia) appear in glycoconjugates. In particular, polySia is known to be a common epitope from bacteria to humans and is one of the most famous, biologically-important glycotopes in vertebrates. The biological functions of polySia, especially on neural cell adhesion molecules (NCAMs), have been well studied and an indepth body of knowledge concerning polySia has been accumulated. However, considerably less attention has been paid to glycoproteins containing di- and oligoSia groups. As the analytical methods used to detect oligo/polymerized structures have been improved, glycoproteins containing di/oligo/polySia chains have been identified with an increasing frequency in nature. In addition, more sophisticated genetic techniques have helped elucidate the underlying mechanisms of polySia-mediated activities. In this chapter, the recent advances in the study of di-, oligo- and polySia residues on glycoproteins, including their distribution, chemical properties, biosynthetic pathways, and functions are described. © 2013 Bentham Science Publishers. All rights reserved.

DOI： 10.2174/9781608053865113010005

Scopus

Advanced Technologies in Sialic Acid and Sialoglycoconjugate Analysis in Top Curr Chem

Kitajima K, Varki N, Sato C.（担当：共著）

Springer 2015年

Advanced Technologies in Sialic Acid and Sialoglycoconjugate Analysis in Top Curr Chem

Kitajima K, Varki N, Sato C（担当：共著）

Springer 2015年

Frontal Affinity Chromatography in the Methods in Molecular Biology

Sato, C. （担当：単著）

Springer 2014年

Flagellasialin in the Glycoscience: Biology and Medicine

Kanazawa, T., Suzuki, E., Miyata, S., Sato, C. and Kitajima, K. （担当：共著）

Springer 2014年

Polysialyltransferase assay in the Glycoscience: Biology and Medicine

Hane, M., Kitajima, K. and Sato, C. （担当：共著）

Springer 2014年

Polysialic acid in the Glycoscience: Biology and Medicine

Sato, C. and Kitajima, K. （担当：共著）

Springer, 2014年

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (ST8SIA2)in Handbook of Glycosyltransferases and related genes

Sato C（担当：単著）

Springer 2014年

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (ST8SIA2)in Handbook of Glycosyltransferases and related genes

Sato C（担当：単著）

Springer 2014年

Flagellasialin in the Glycoscience: Biology and Medicine

Kanazawa, T, Suzuki, E, Miyata, S, Sato, C, Kitajima, K（担当：共著）

Springer 2014年

Polysialyltransferase assay in the Glycoscience: Biology and Medicine

Hane, M, Kitajima, K, Sato, C（担当：共著）

Springer 2014年

Polysialic acid in the Glycoscience: Biology and Medicine

Sato, C, Kitajima, K（担当：共著）

Springer, 2014年

Frontal Affinity Chromatography in the Methods in Molecular Biology

Sato, C（担当：単著）

Springer 2014年

Sialobiology: Structure, Function and Biosynthesis

Sato C（担当：共著）

Bentham Science 2013年

Sialobiology: Structure, Function and Biosynthesis

Sato C（担当：共著）

Bentham Science 2013年

Methods in Enzymology・ Analysis of glycan-protein interaction by frontal affinity chromatography and Biacore.

Sato, C., Yamakawa, N., and Kitajima, K.（担当：共著）

Elsevir science 2010年

Methods in Enzymology・ Analysis of glycan-protein interaction by frontal affinity chromatography and Biacore.

Sato, C, Yamakawa, N, Kitajima, K（担当：共著）

Elsevir science 2010年

Carbohydrate Recognition: Biological problems, methods, and applications

Ken Kitajima and Chihiro Sato (Editors: Binghe Wang, Geer-Jan Boons)（担当：共著）

John Wiley and Sons 2009年

Carbohydrate Recognition: Biological problems, methods, and applications

Ken Kitajima, Chihiro Sato, Binghe Wang, Geer-Jan Boons（担当：共著）

John Wiley and Sons 2009年

Membrane microdomain as a platform of carbohydrate-mediated interactions during early development of medaka fish.

Adachi, T., Sato, C., and Kitajima, K.（担当：共著）

KINPO-DO 2008年

Glycoscience Lab Manual・Structure analysis of oligo/polysialic acid

C. Sato and K. Kitajima（担当：共著）

KINPO-DO 2008年

Glycoscience Lab Manual・Labeling of oligosialic acid

C. Sato（担当：共著）

KINPO-DO 2008年

Glycoscience Lab Manual・Labeling of oligosialic acid

C. Sato（担当：共著）

KINPO-DO 2008年

Membrane microdomain as a platform of carbohydrate-mediated interactions during early development of medaka fish.

Adachi, T, Sato, C, Kitajima, K（担当：共著）

KINPO-DO 2008年

Glycoscience Lab Manual・Structure analysis of oligo/polysialic acid

C. Sato, K. Kitajima（担当：共著）

KINPO-DO 2008年

未来を拓く糖鎖科学・オリゴシアル酸の標識

（担当：共著）

金芳堂 2005年

遺伝子医学MOOK 糖鎖と病気・ポリシアル酸

佐藤ちひろ、北島　健（担当：共著）

メディカルデュー 2005年

未来を拓く糖鎖科学・オリゴシアル酸の標識

（担当：共著）

金芳堂 2005年

遺伝子医学MOOK 糖鎖と病気・ポリシアル酸

佐藤ちひろ, 北島健（担当：共著）

メディカルデュー 2005年

Recent Research Developments in Analytical Biochemistry・Detection of di/oligo/polysialic acid units in glycoproteins

"C. Sato, and K. Kitajima"（担当：共著）

Transworld research network 2002年

Recent Research Developments in Analytical Biochemistry・Detection of di/oligo/polysialic acid units in glycoproteins

C. Sato, K. Kitajima（担当：共著）

Transworld research network 2002年

Leukocyte typing VII・Carbohydrate-recognizing monoclonal antibodies as revealed by ELISA using phosphatidylethanolamine-conjugated oligosaccharides as antigens

C. Sato and K. Kitajima（担当：共著）

OXFORD 2001年

Leukocyte typing VII・Oligosialic acid as a differentiation-associated antigen in human haematopoietic cell line HL60.

C. Sato and K. Kitajima（担当：共著）

OXFORD 2001年

Leukocyte typing VII・Carbohydrate-recognizing monoclonal antibodies as revealed by ELISA using phosphatidylethanolamine-conjugated oligosaccharides as antigens

C. Sato, K. Kitajima（担当：共著）

OXFORD 2001年

Leukocyte typing VII・Oligosialic acid as a differentiation-associated antigen in human haematopoietic cell line HL60.

C. Sato, K. Kitajima（担当：共著）

OXFORD 2001年

Sialobiology and Other Novel Form of Glycosylation・Occurrence of a2,8-linked oligosialic acid residues in mammalian glycoproteins.

K. Kitajima, C. Sato, N. Honda, T. Matsuda, M.-H. Yokoyama, B. E. Close, and K. J. Colley（担当：共著）

Gakushin 1999年

Sialobiology and Other Novel Form of Glycosylation・Occurrence of a2,8-linked oligosialic acid residues in mammalian glycoproteins.

K. Kitajima, C. Sato, N. Honda, T. Matsuda, M.-H. Yokoyama, B. E. Close, K. J. Colley（担当：共著）

Gakushin 1999年

KDN(=デアミノノイラミン酸)-転移酸素およびポリKDN-転移酵素の研究 : 各種KDN-転移酵素の利用による機能性KDN-複合糖質の造成と活用

井上康男（担当：単著）

井上康男 1994年

KDN(=デアミノノイラミン酸)-転移酸素およびポリKDN-転移酵素の研究 : 各種KDN-転移酵素の利用による機能性KDN-複合糖質の造成と活用

井上康男（担当：単著）

井上康男 1994年

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