Papers - UENOYAMA Yoshihisa
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Involvement of nuclear receptor corepressor 2 (NCOR2) in estrogen-induced repression of arcuate Kiss1 expression in female rats Reviewed
"Takizawa, M. Miyazaki, S. Tsuchida, H. Nagae, M. Seki, S. Hirabayashi, M. Osakada, F. Inoue, N. Tsukamura, H. Uenoyama, Y."
J Reprod Dev 2025.1
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AVPV Kiss1 neuron-specific knockdown of purinergic P2X2 receptor suppresses LH surge and ovulation in Kiss1-Cre rats Invited Reviewed
"Hazim, S. Seki, S. Yabushita, R. Nagae, M. Tsuchida, H. Hirabayashi, M. Uenoyama, Y. Tsukamura, H. Inoue, N."
J Reprod Dev Vol. 70 ( 6 ) page： 379 - 388 2024.12
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Absence of sex differences in diabetes-induced suppression of KNDy neurons in rats Reviewed
Otsuka M, Iwata K, Otsuka Y, Uenoyama Y, Ozawa H, Ishii H
J Endocrinol 2024.10
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Central δ/κ opioid receptor signaling pathways mediate chronic and/or acute suckling-induced LH suppression in rats during late lactation Reviewed
Uenoyama Y, Nonogaki M, Tsuchida H, Takizawa M, Matsuzaki S, Inoue N, Tsukamura H
J Reprod Dev 2024.8
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Raphe glucose-sensing serotonergic neurons stimulate KNDy neurons to enhance LH pulses via 5HT2CR: rat and goat studies Reviewed
Nakamura S, Sasaki T, Uenoyama Y, Inoue N, Nakanishi M, Yamada K, Morishima A, Suzumura R, Kitagawa Y, Morita Y, Ohkura S, Tsukamura H
Scientific Reports Vol. 14 page： 10190 2024.5
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Neonatal aromatase inhibition blocked defeminization of AVPV Kiss1 neurons and LH surge-generating system in male rats Reviewed
Yamada K, Mano T, Hazim S, Takizawa M, Inoue N, Uenoyama Y, Tsukamura H
Endocrinology Vol. 165 ( 4 ) 2024.3
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Capturing temperature changes on the ocular surface along with estrus and ovulation using infrared thermography in Japanese Black cows Reviewed
Ozaki R, Inoue S, Yorozui Y, Ichikawa R, Yamada N, Higashi S, Matsuyama S, Tsukamura H, Ohkura S, Uenoyama Y, Morita Y
J Reprod Dev Vol. 70 ( 1 ) page： 49 - 54 2023.11
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Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats Reviewed
Nagae M, Yamada K, Enomoto Y, Kometani M, Tsuchida H, Panthee A, Nonogaki M, Matsunaga N, Takizawa M, Matsuzaki S, Hirabayashi M, Inoue N, Tsukamura H, Uenoyama Y
Scientific Reports Vol. 13 ( 1 ) 2023.11
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Sex difference in developmental changes in visualized Kiss1 neurons in newly generated Kiss1-Cre rats Reviewed
Yamada K, Nagae M, Mano T, Tsuchida H, Hazim S, Goto T, Sanbo M, Hirabayashi M, Inoue N, Uenoyama Y, Tsukamura H
J Reprod Dev Vol. 69 ( 5 ) page： 227 - 238 2023.7
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Enkephalin-δ opioid receptor signaling partly mediates suppression of LH release during early lactation in rats Reviewed
Tsuchida H, Takizawa M, Nonogaki M, Inoue N, Uenoyama Y, Tsukamura H
J Reprod Dev Vol. 69 ( 4 ) 2023.6
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Kisspeptin and lactational anestrus: Current understanding and future prospects Invited Reviewed
Uenoyama Y, Inoue N, Tsukamura H
Peptides Vol. 166 2023.5
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KNDy neurones and GnRH/LH pulse generation: Current understanding and future aspects Invited Reviewed
Uenoyama Y, Tsukamura H
J Neuroendocrinol Vol. 35 2023.5
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Hindbrain Adenosine 5-Triphosphate (ATP)-Purinergic Signaling Triggers LH Surge and Ovulation via Activation of AVPV Kisspeptin Neurons in Rats. Reviewed
Inoue N, Hazim S, Tsuchida H, Dohi Y, Ishigaki R, Takahashi A, Otsuka Y, Yamada K, Uenoyama Y, Tsukamura H
The Journal of neuroscience Vol. 43 ( 12 ) page： 2140 - 2152 2023.3
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Enkephalin-δ Opioid Receptor Signaling Mediates Glucoprivic Suppression of LH Pulse and Gluconeogenesis in Female Rats. Reviewed
Tsuchida H, Nonogaki M, Takizawa M, Inoue N, Uenoyama Y, Tsukamura H
Endocrinology Vol. 164 ( 3 ) 2023.1
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Intronic Enhancer Is Essential for Nr5a1 Expression in the Pituitary Gonadotrope and for Postnatal Development of Male Reproductive Organs in a Mouse Model Invited Reviewed
Shima Yuichi, Miyabayashi Kanako, Mori Takami, Ono Koji, Kajimoto Mizuki, Cho Hae Lim, Tsuchida Hitomi, Uenoyama Yoshihisa, Tsukamura Hiroko, Suzuki Kentaro, Choi Man Ho, Toida Kazunori
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 24 ( 1 ) 2023.1
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Dynorphin-Kappa-opioid receptor signaling, but not mu-opioid receptor signaling, partly mediates the suppression of luteinizing hormone release during late lactation in rats Invited Reviewed
Tsuchida Hitomi, Nonogaki Miku, Inoue Naoko, Uenoyama Yoshihisa, Tsukamura Hiroko
Neuroscience letters Vol. 791 page： 136920 2022.11
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Establishment of embryo transfer in the musk shrew (Suncus murinus). Reviewed
Inoue N, Hotta A, Goto T, Hirabayashi M, Uenoyama Y, Tsukamura H
The Journal of reproduction and development Vol. 66 ( 5 ) page： 340 - 344 2022.10
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Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals Invited Reviewed
Uenoyama Y, Tsuchida H, Nagae M, Inoue N, Tsukamura H
Front Neurosci Vol. 16 page： 958377 2022.9
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A Survey of Genome-Wide Genetic Characterizations of Crossbred Dairy Cattle in Local Farms in Cambodia Invited Reviewed International coauthorship
Somony Mam, Bengthay Tep, Soriya Rin, Yoshihisa Uenoyama, Shuichi Matsuyama, Satoshi Ohkura, Tetsuma Murase, Mitsuo Nunome, Yasuhiro Morita
Animals Vol. 12 ( 16 ) page： 2072 2022.8
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Central somatostatin-somatostatin receptor 2 signaling mediates lactational suppression of luteinizing hormone release via the inhibition of glutamatergic interneurons during late lactation in rats Reviewed
Sugimoto A, Tsuchida H, Nagae M, Inoue N, Uenoyama Y, Tsukamura H
J Reprod Dev Vol. 68 ( 3 ) page： 190 - 197 2022.6
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Generation of Tfap2c-T2A-tdTomato knock-in reporter rats via adeno-associated virus-mediated efficient gene targeting Reviewed
Oikawa M, Nagae M, Mizuno N, Iwatsuki K, Yoshida F, Inoue N, Uenoyama Y, Tsukamura H, Nakauchi H, Hirabayashi M, Kobayashi T
Mol Reprod Dev Vol. 89 page： 129–132 2022.2
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Kiss1-dependent and independent release of luteinizing hormone and testosterone in perinatal male rats Reviewed
Chen J, Minabe S, Munetomo A, Magata F, Sato M, Nakamura S, Hirabayashi M, Ishihara Y, Yamazaki T, Uenoyama Y, Tsukamura H, Matsuda F
Endocrine Journal 2022.2
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Cellular and molecular mechanisms regulating the KNDy neuronal activities to generate and modulate GnRH pulse in mammals Reviewed
Ikegami K, Watanabe Y, Nakamura S, Goto T, Inoue N, Uenoyama Y, Tsukamura H
Front Neuroendocrinol Vol. 64 page： 100968 2021.11
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Kisspeptin neurons as a key player bridging the endocrine system and sexual behavior in mammals Reviewed
Nakamura S, Watanabe Y, Goto T, Ikegami K, Inoue N, Uenoyama Y, Tsukamura H
Front Neuroendocrinol Vol. 64 page： 100952 2021.11
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Role of KNDy neurons expressing kisspeptin, neurokinin B, and dynorphin A as a GnRH pulse generator controlling mammalian reproduction Reviewed
Uenoyama Y, Nagae M, Tsuchida H, Inoue N, Tsukamura H
Front Endocrinol (Lausanne) Vol. 12 page： 724632 2021.9
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Kisspeptin neurons and estrogen-estrogen receptor α signaling: Unraveling the mystery of steroid feedback system regulating mammalian reproduction Reviewed
Uenoyama Y, Inoue N, Nakamura S, Tsukamura H
Int J Mol Sci Vol. 22 page： 9229 2021.9
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Central μ-opioid receptor antagonism blocks glucoprivic LH pulse suppression and gluconeogenesis/feeding in female rats Reviewed
Tsuchida H, Kawai N, Yamada K, Takizawa M, Inoue N, Uenoyama Y, Tsukamura H
Endocrinology Vol. 162 page： bqab140 2021.7
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Morphological Analysis of the Hindbrain Glucose Sensor-Hypothalamic Neural Pathway Activated by Hindbrain Glucoprivation Reviewed
Sato M, Minabe S, Sakono T, Magata F, Nakamura S, Watanabe Y, Inoue N, Uenoyama Y, Tsukamura H, Matsuda F
Endocrinology Vol. 162 page： bqab125 2021.6
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Reduction of arcuate kappa-opioid receptor-expressing cells increased luteinizing hormone pulse frequency in female rats Reviewed
Dai M, Nakamura S, Takahashi C, Sato M, Munetomo A, Magata F, Uenoyama Y, Tsukamura H, Matsuda F
Endocr J 2021.4
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Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator. Reviewed
Nagae M, Uenoyama Y, Okamoto S, Tsuchida H, Ikegami K, Goto T, Majarune S, Nakamura S, Sanbo M, Hirabayashi M, Kobayashi K, Inoue N, Tsukamura H
Proceedings of the National Academy of Sciences of the United States of America Vol. 118 ( 5 ) page： e2009156118 2021.2
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Paraventricular Dynorphin A Neurons Mediate LH Pulse Suppression Induced by Hindbrain Glucoprivation in Female Rats. Reviewed
Tsuchida H, Mostari P, Yamada K, Miyazaki S, Enomoto Y, Inoue N, Uenoyama Y, Tsukamura H
Endocrinology Vol. 161 ( 11 ) 2020.11
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Facilitatory and inhibitory role of central amylin administration in the regulation of the gonadotropin-releasing hormone pulse generator activity in goats Reviewed
Kitagawa Y, Sasaki T, Suzumura R, Morishima A, Tatebayashi R, Assadullah, Ieda N, Morita Y, Matsuyama S, Inoue N, Uenoyama Y, Tsukamura H, Ohkura S
Neuroscience Letters Vol. 736 page： 135276 2020.9
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Mating-induced increase in Kiss1 mRNA expression in the anteroventral periventricular nucleus prior to an increase in LH and testosterone release in male rats. Reviewed
Watanabe Y, Ikegami K, Nakamura S, Uenoyama Y, Ozawa H, Maeda KI, Tsukamura H, Inoue N
The Journal of Reproduction and Development Vol. 66 page： 579 - 586 2020.9
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Testosterone Supplementation Rescues Spermatogenesis and In Vitro Fertilizing Ability of Sperm in Kiss1 Knockout Mice Reviewed
Goto T, Hirabayashi M, Watanabe Y, Sanbo M, Tomita K, Inoue N, Tsukamura H, Uenoyama Y
Endocrinology Vol. 161 ( 9 ) page： bqaa092 2020.9
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Conditional kisspeptin neuron-specific Kiss1 knockout with newly generated Kiss1-floxed and Kiss1-Cre mice replicates a hypogonadal phenotype of global Kiss1 knockout mice. Reviewed
Ikegami K, Goto T, Nakamura S, Watanabe Y, Sugimoto A, Majarune S, Horihata K, Nagae M, Tomikawa J, Imamura T, Sanbo M, Hirabayashi M, Inoue N, Maeda KI, Tsukamura H, Uenoyama Y
The Journal of Reproduction and Development Vol. 66 ( 4 ) page： 359 - 367 2020.8
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Inducible Kiss1 knockdown in the hypothalamic arcuate nucleus suppressed pulsatile secretion of luteinizing hormone in male mice. Reviewed
Minabe S, Nakamura S, Fukushima E, Sato M, Ikegami K, Goto T, Sanbo M, Hirabayashi M, Tomikawa J, Imamura T, Inoue N, Uenoyama Y, Tsukamura H, Maeda KI, Matsuda F
The Journal of Reproduction and Development Vol. 66 ( 4 ) page： 369 - 375 2020.8
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Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats. Reviewed
Sasaki T, Sonoda T, Tatebayashi R, Kitagawa Y, Oishi S, Yamamoto K, Fujii N, Inoue N, Uenoyama Y, Tsukamura H, Maeda KI, Matsuda F, Morita Y, Matsuyama S, Ohkura S
The Journal of Reproduction and Development Vol. 66 ( 4 ) page： 351 - 357 2020.8
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Establishment of immortalised cell lines derived from female Shiba goat KNDy and GnRH neurones Reviewed
Suetomi Y, Tatebayashi R, Sonoda S, Munetomo A, Matsuyama S, Inoue N, Uenoyama Y, Takeuchi Y, Tsukamura H, Ohkura S, Matsuda F
Journal of Neuroendocrinology Vol. 32 ( 6 ) page： e12857 2020.6
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GnRH(1-5), a metabolite of gonadotropin-releasing hormone, enhances luteinizing hormone release via activation of kisspeptin neurons in female rats Reviewed
Ieda N, Assadullah, Minabe S, Ikegami K, Watanabe Y, Sugimoto Y, Sugimoto A, Kawai N, Ishii H, Inoue N, Uenoyama Y, Tsukamura H
Endocrine Journal Vol. 67 ( 4 ) page： 409 - 418 2020.4
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Seasonal changes in the reproductive performance in local cows receiving artificial insemination in the Pursat province of Cambodia. Reviewed International coauthorship
Tep B, Morita Y, Matsuyama S, Ohkura S, Inoue N, Tsukamura H, Uenoyama Y, Pheng V
Asian-Australasian Journal of Animal Sciences 2020.4
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Retinoblastoma binding protein 7 is involved in Kiss1 mRNA upregulation in rodents. Reviewed
Horihata K, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H
The Journal of Reproduction and Development Vol. 66 ( 2 ) page： 125 - 133 2020.4
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Role of kisspeptin neurons as a GnRH surge generator: Comparative aspects in rodents and non-rodent mammals Reviewed
Matsuda F, Ohkura S, Magata F, Munetomo A, Chen J, Sato M, Inoue N, Uenoyama Y, Tsukamura H
Journal Of Obstetrics And Gynaecology Research Vol. 45 ( 12 ) page： 2318 - 2329 2019.12
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Ad libitum feeding triggers puberty onset associated with increases in arcuate Kiss1 and Pdyn expression in growth-retarded rats. Reviewed
Majarune S, Nima P, Sugimoto A, Nagae M, Inoue N, Tsukamura H, Uenoyama Y
The Journal of reproduction and development Vol. 65 ( 5 ) page： 397-406 2019.10
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Peripheral administration of kappa-opioid receptor antagonist stimulates gonadotropin-releasing hormone pulse generator activity in ovariectomized, estrogen-treated female goats
Sasaki T., Ito D., Sonoda T., Morita Y., Wakabayashi Y., Yamamura T., Okamura H., Oishi S., Noguchi T., Fujii N., Uenoyama Y., Tsukamura H., Maeda K. I, Matsuda F., Ohkura S.
DOMESTIC ANIMAL ENDOCRINOLOGY Vol. 68 page： 83-91 2019.7
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Central Mechanism Controlling Pubertal Onset in Mammals: A Triggering Role of Kisspeptin
Uenoyama Y, Inoue N, Nakamura S, Tsukamura H
FRONTIERS IN ENDOCRINOLOGY Vol. 10 page： 312 2019.5
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Neonatal Estrogen Causes Irreversible Male Infertility via Specific Suppressive Action on Hypothalamic Kiss1 Neurons
Minabe Shiori, Sato Marimo, Inoue Naoko, Watanabe Youki, Magata Fumie, Matsuda Fuko, Uenoyama Yoshihisa, Ozawa Hitoshi, Tsukamura Hiroko
ENDOCRINOLOGY Vol. 160 ( 5 ) page： 1223-1233 2019.5
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Morphological analysis for neuronal pathway from the hindbrain ependymocytes to the hypothalamic kisspeptin neurons.
Deura C, Minabe S, Ikegami K, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H
The Journal of reproduction and development Vol. 65 ( 2 ) page： 129-137 2019.4
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Kisspeptin: A Central Regulator of Reproduction in Mammals Invited Reviewed
Ieda N, Hassaneen ASA, Inoue N, Uenoyama Y, Tsukamura H
SVU- International Journal of Veterinary Sciences Vol. 3. ( 1 ) page： 10 - 26 2019
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Study on the Reproductive Performance and Problems in Crossbred Cows in Jalalabad, East of Afghanistan Invited Reviewed
Assadullah, Ieda N, Bayer DM, Stanikzai PM, Memlawal R, Inoue N, Uenoyama Y, Tsukamura H
J Intl Cooper Agric Dev Vol. 17 page： 2 - 7 2019
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The roles of kisspeptin in the mechanism underlying reproductive functions in mammals.
Uenoyama Y, Inoue N, Maeda KI, Tsukamura H
The Journal of reproduction and development 2018.10
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Co-expression of the calcitonin receptor gene in the hypothalamic kisspeptin neurons in female rats.
Assadullah, Ieda N, Kawai N, Ishii H, Ihara K, Inoue N, Uenoyama Y, Tsukamura H
Reproductive medicine and biology Vol. 17 ( 2 ) page： 164-172 2018.4
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Somatostatin-Somatostatin Receptor 2 Signaling Mediates LH Pulse Suppression in Lactating Rats
Sugimoto A, Tsuchida H, Ieda N, Ikegami K, Inoue N, Uenoyama Y, Tsukamura H
ENDOCRINOLOGY Vol. 160 ( 2 ) page： 473 - 483 2018
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SB223412, a neurokinin-3 receptor-selective antagonist, suppresses testosterone secretion in male guinea pigs
Nakamura Sho, Ito Yoshiko, Yamamoto Koki, Takahashi Chudai, Dai Mingdao, Tanahashi Miyu, Uenoyama Yoshihisa, Tsukamura Hiroko, Oishi Shinya, Maeda Kei-ichiro, Matsuda Fuko
THERIOGENOLOGY Vol. 102 page： 183-189 2017
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Long-Term Neonatal Estrogen Exposure Causes Irreversible Inhibition of LH Pulses by Suppressing Arcuate Kisspeptin Expression via Estrogen Receptors alpha and beta in Female Rodents
Minabe Shiori, Ieda Nahoko, Watanabe Youki, Inoue Naoko, Uenoyama Yoshihisa, Maeda Kei-ichiro, Tsukamura Hiroko
ENDOCRINOLOGY Vol. 158 ( 9 ) page： 2918-2929 2017
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Evolutionally Conserved Function of Kisspeptin Neuronal System Is Nonreproductive Regulation as Revealed by Nonmammalian Study
Nakajo Mikoto, Kanda Shinji, Karigo Tomomi, Takahashi Akiko, Akazome Yasuhisa, Uenoyama Yoshihisa, Kobayashi Makito, Oka Yoshitaka
ENDOCRINOLOGY Vol. 159 ( 1 ) page： 163-183 2017
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Evidence of involvement of neurone-glia/neurone-neurone communications via gap junctions in synchronised activity of KNDy neurones
Ikegami K., Minabe S., Ieda N., Goto T., Sugimoto A., Nakamura S., Inoue N., Oishi S., Maturana A. D., Sanbo M., Hirabayashi M., Maeda K-I, Tsukamura H., Uenoyama Y.
JOURNAL OF NEUROENDOCRINOLOGY Vol. 29 ( 6 ) 2017
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Evaluation of heat stress response in crossbred dairy cows under tropical climate by analysis of heart rate variability
Bun Chan, Watanabe Youki, Uenoyama Yoshihisa, Inoue Naoko, Ieda Nahoko, Matsuda Fuko, Tsukamura Hiroko, Kuwahara Masayoshi, Maeda Kei-ichiro, Ohkura Satoshi, Pheng Vutha
JOURNAL OF VETERINARY MEDICAL SCIENCE Vol. 80 ( 1 ) page： 181-185 2017
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Enhancement of the luteinising hormone surge by male olfactory signals is associated with anteroventral periventricular Kiss1 cell activation in female rats
Watanabe Y, Ikegami K, Ishigaki R, Ieda N, Uenoyama Y, Maeda KI, Tsukamura H, Inoue N
JOURNAL OF NEUROENDOCRINOLOGY Vol. 29 ( 8 ) 2017
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CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene
Hirose M, Hasegawa A, Mochida K, Matoba S, Hatanaka Y, Inoue K, Goto T, Kaneda H, Yamada I, Furuse T, Abe K, Uenoyama Y, Tsukamura H, Wakana S, Honda A, Ogura A
SCIENTIFIC REPORTS Vol. 7 page： 42476 2017
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Characterization of smallholder livestock farming in Kampong Cham province, Cambodia -A pilot study in Prey Chhor district-. Invited Reviewed
Ieda N, Watanabe Y, Bun C, Pheng V, Uenoyama Y
J Intl Cooper Agric Dev Vol. 15 page： 42 - 47 2017
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Immunohistochemical characterization of the arcuate kisspeptin/neurokinin B/dynorphin (KNDy) and preoptic kisspeptin neuronal populations in the hypothalamus during the estrous cycle in heifers Reviewed
Hassaneen ASA, Naniwa Y, Suetomi Y, Matsuyama S, Kimura K, Ieda N, Inoue N, Uenoyama Y, Tsukamura H, Maeda K-I, Matsuda F, Ohkura S
J Reprod Dev Vol. 62 page： 471-477 2016
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The roles of kisspeptin revisited: inside and outside the hypothalamus Invited Reviewed
Uenoyama Y, Pheng V, Tsukamura H, Maeda K.
J Reprod Dev Vol. 62 page： 537-545 2016
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Neonatal kisspeptin is steroid-independently required for defeminisation and peripubertal kisspeptin-induced testosterone is required for masculinisation of the brain Reviewed
Nakamura S, Uenoyama Y, Ikegami K, Dai M, Watanabe Y, Takahashi C, Hirabayashi M, Tsukamura H, Maeda KI.
J Neuroendocrinol page： 10.1111/jne.12409 2016
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Molecular and epigenetic mechanism regulating hypothalamic Kiss1 gene expression in mammals Invited Reviewed
Uenoyama Y, Tomikawa J, Inoue N, Goto T, Minabe S, Ieda N, Nakamura S, Watanabe Y, Ikegami K, Matsuda F, Ohkura S, Maeda KI, Tsukamura H
Neuroendocrinology Vol. 103 page： 640 - 649 2016
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Pharmacological and morphological evidence of AMPK-mediated energy sensing in the lower brain stem ependymocytes to control reproduction in female rodents Reviewed
Minabe S, Deura C, Ikegami K, Goto T, Sanbo M, Hirabayashi M, Inoue N, Uenoyama Y, Maeda KI, Tsukamura H
Endocrinology Vol. 156 page： 2278-2287 2015.6
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The LH surge-generating system is functional in male goats as in females: involvement of kisspeptin neurones in the medial preoptic area
Matsuda, F., Nakatsukasa, K., Suetomi, Y., Naniwa, Y., Ito, D., Inoue, N., Wakabayashi, Y., Okamura, H., Maeda, K.I., Uenoyama, Y., Tsukamura, H. and Ohkura, S.
J. Neuroendocrinol. Vol. 27 page： 57-65 2015
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Identification of hypothalamic arcuate nucleus-specific enhancer region of Kiss1 gene in mice Reviewed
Goto, T., Tomikawa, J., Ikegami, K., Minabe, S., Abe, H., Fukanuma, T., Imamura, T., Takase, K., Sanbo, M., Tomita, K., Hirabayashi, M., Maeda, K.I., Tsukamura, H. and Uenoyama, Y.
Mol. Endocrinol. Vol. 29 page： 121-129 2015
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Lack of pulse and surge modes and glutamatergic stimulation of LH release in Kiss1 knockout rats. Reviewed
Uenoyama Y, Nakamura S, Hayakawa Y, Ikegami K, Watanabe Y, Deura C, Minabe S, Tomikawa J, Goto T, Ieda N, Inoue N, Sanbo M, Tamura C, Hirabayashi M, Maeda KI, Tsukamura H
J. Neuroendocrinol. Vol. 27 page： 187 - 197 2015
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Central estrogen action sites involved in prepubertal restraint of pulsatile luteinizing hormone release in female rats Reviewed
Uenoyama Y, Tanaka A, Takase K, Yamada S, Pheng V, Inoue N, Maeda KI, Tsukamura H
Journal of Reproduction and Development Vol. 61 page： 351-359 2015
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Design and synthesis of fluorescent probes for GPR54
Kaneda, M., Misu, R., Ohno, H., Hirasawa, A., Ieda, N., Uenoyama, Y., Tsukamura, H., Maeda, K.I., Oishi, S. and Fujii, N.
Bioorg. Med. Chem. Vol. 22 page： 3325-3330 2014
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KISS1 gene expression in the developing brain of female pigs in pre- and peripubertal periods.
Ieda, N., Uenoyama, Y., Tajima, Y., Nakata, T., Kano, M., Naniwa, Y., Watanabe, Y., Minabe, S., Tomikawa, J., Inoue, N., Matsuda, F., Ohkura, S., Maeda, K.I. and Tsukamura, H
J. Reprod. Dev. Vol. 60 page： 312-316 2014
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Oestrogen-induced activation of preoptic kisspeptin neurones may be involved in the luteinizing hormone surge in male and female Japanese monkeys
Watanabe, Y., Uenoyama, Y., Suzuki, J., Takase, K., Suetomi, Y., Ohkura, S., Inoue, N., Maeda, K.I. and Tsukamura, H
J. Neuroendocrinol. Vol. 26 page： 909-917 2014
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KNDy neuron as a gatekeeper of puberty onset Invited Reviewed
Uenoyama Y, Tsukamura H, Maeda KI
J Obstet Gynaecol Res Vol. 40 page： 1518 - 1526 2014
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Microarray Analysis of Perinatal-Estrogen-Induced Changes in Gene Expression Related to Brain Sexual Differentiation in Mice
Sakakibara M, Uenoyama Y, Minabe S, Watanabe Y, Deura C, Nakamura S, Suzuki G, Maeda K-I and Tsukamura H
PLoS ONE Vol. 8 page： e79437 2013.11
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Effects of Full-Length Kisspeptin Administration on Follicular Development in Japanese Black Beef Cows
Naniwa Y, Nakatsukasa K, Setsuda S, Oishi S, Fujii N, Matsuda F, Uenoyama Y, Tsukamura H, Maeda KI, Ohkura S
J Reprod Dev Vol. 59 page： 588–594 2013.8
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Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats
Nakahara T, Uenoyama Y, Iwase A, Oishi S, Nakamura S, Minabe S, Watanabe Y, Deura C, Noguchi T, Fujii N, Kikkawa F, Maeda KI, Tsukamura H
J Reprod Dev Vol. 59 page： 479-484 2013.6
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Molecular cloning and identification of the transcriptional regulatory domain of the goat neurokinin B Gene TAC3
Suetomi Y, Matsuda F, Uenoyama Y, Maeda KI, Tsukamura H, Ohkura S
J Reprod Dev Vol. 59 page： 463-469 2013.3
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Dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats Reviewed
Mostari MP, Ieda N, Deura C, Minabe S, Yamada S, Uenoyama Y, Maeda KI, Tsukamura H
Vol. 59 page： 266–272 2013.1
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Central distribution of kiss2 neurons and peri-pubertal changes in their expression in the brain of male and female red seabream Pagrus major
Shimizu Y, Tomikawa J, Hirano K, Nanikawa Y, Akazome Y, Kanda S, Kazeto Y, Okuzawa K, Uenoyama Y, Ohkura S, Tsukamura H, Maeda KI, Gen K, Oka Y, Yamamoto N
Gen Comp Endocrinol Vol. 175 page： 432-442 2012
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Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain
Tomikawa J, Uenoyama Y, Ozawa M, Fukanuma T, Takase K, Goto T, Abe H, Ieda N, Minabe S, Deura C, Inoue N, Sanbo M, Tomita K, Hirabayashi M, Tanaka S, Imamura T, Okamura H, Maeda KI, Tsukamura H
Proc Natl Acad Sci USA 2012
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Oestrogen-Dependent Suppression of Pulsatile Luteinizing Hormone Secretion and Kiss1 mRNA Expression in the Arcuate Nucleus During Late Lactation in Rats Reviewed
Yamada S, Uenoyama Y, Deura C, Minabe S, Naniwa Y, Iwata K, Kawata M, Maeda KI, Tsukamura H
J Neuroendocrinol Vol. 24 page： 1234-1242 2012
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Different Critical Perinatal Periods and Hypothalamic Sites of Oestradiol Action in the Defeminization of LH Surge and Lordosis Capacity in the Rat
Sakakibara M, Deura C, Minabe S, Iwata Y, Uenoyama Y, Maeda KI, Tsukamura H
J Neuroendocrinol 2012
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Kisspeptin neurons mediate reflex ovulation in the musk shrew (Suncus murinus)
Inoue N, Sasagawa K, Ikai K, Sasaki Y, Tomikawa J, Oishi S, Fujii N, Uenoyama Y, Ohmori Y, Yamamoto N, Hondo E, Maeda K and Tsukamura H
Proc Natl Acad Sci USA Vol. 108 page： 17527-32 2011
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Central Injection of Ketone Body Suppresses Luteinizing Hormone Release via the Catecholaminergic Pathway in Female Rats
Iwata K, Kinoshita M, Susaki N, Uenoyama Y, Tsukamura H and Maeda KI
J Reprod Dev Vol. 57 page： 379-384 2011
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Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats. Invited Reviewed
Iwata K, Kinoshita M, Yamada S, Imamura T, Uenoyama Y, Tsukamura H and Maeda KI
J Physiol Sci Vol. 61 page： 103 - 113 2011
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Ultrastructural evidence of kisspeptin-gonadotrophin-releasing hormone interaction in the median eminence of female rats: Implication of axo-axonal regulation of GnRH release Invited Reviewed
Uenoyama Y, Inoue N, Pheng V, Homma T, Takase K, Yamada S, Ajiki K, Ichikawa M, Okamura H, Maeda KI and Tsukamura H
J Neuroendocrinol Vol. 23 page： 863 - 870 2011
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Testicular toxicity induced by a triple neurokinin receptor antagonist in male dogs Invited Reviewed
Noritake KI, Suzuki J, Matsuoka T, Makino T, Ohnishi H, Shimomura K, Uenoyama Y, Tsukamura H, Maeda KI and Sanbuissho A
Reprod Toxicol Vol. 31 page： 440 - 446 2011
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Involvement of neurokinin receptors in the control of pulsatile luteinizing hormone secretion in rats Invited Reviewed
Noritake KI, Matsuoka T, Ohsawa T, Shimomura K, Sanbuissho A, Uenoyama Y, Maeda KI and Tsukamura H
J Reprod Dev Vol. 57 page： 409 - 415 2011
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Analysis of pulsatile and surge-like luteinizing hormone secretion with frequent blood sampling in female mice Invited Reviewed
Minabe S, Uenoyama Y, Tsukamura H and Maeda KI
J Reprod Dev Vol. 57 page： 660 - 664 2011
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Molecular characterization and estrogen regulation of hypothalamic Kiss1 gene in the pig Reviewed
Tomikawa J, Homma T, Tajima S, Shibata T, Inamoto Y, Takase K, Inoue N, Ohkura S, Uenoyama Y, Maeda KI and Tsukamura H
Biology of Reproduction Vol. 82 page： 313-319 2010.2
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Activation of Neuropeptide FF Receptors by Kisspeptin Receptor Ligands Reviewed
Oishi S, Misu R, Tomita K, Setsuda S, Masuda R, Ohno H, Naniwa Y, Ieda N, Inoue N, Ohkura S, Uenoyama Y, Tsukamura H, Maeda K, Hirasawa A, Tsujimoto G, Fujii N
ACS Medicinal Chemistry Letters page： in press 2010
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Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus Reviewed
Maeda KI, Ohkura S, Uenoyama Y, Wakabayashi Y, Oka Y, Tsukamura H, Okamura H
Brain Res page： in press 2010
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Sexual differentiation of kisspeptin neurons responsible for sex difference in gonadotropin release in rats Invited Reviewed
Tsukamura H, Homma T, Tomikawa J, Uenoyama Y and Maeda K
Ann N Y Acad Sci Vol. 1200 page： 95 - 103 2010
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Significance of Neonatal Testicular Sex Steroids to Defeminize Anteroventral Periventricular Kisspeptin Neurons and the GnRH/LH Surge System in Male Rats Reviewed
Homma T., Sakakibara M., Yamada S., Kinoshita M., Iwata K., Tomikawa J., Kanazawa T., Matsui H., Takatsu Y., Ohtaki T., Matsumoto H., Uenoyama Y., Maeda K.I, Tsukamura H.
Biology of Reproduction Vol. 81 ( 6 ) page： 1216-25 2009.12
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Potencies of Centrally- or Peripherally-Injected Full-Length Kisspeptin or Its C-Terminal Decapeptide on LH Release in Intact Male Rats Reviewed
Pheng V., Uenoyama Y., Homma T., Inamoto Y., Takase K., Yoshizawa-Kumagaye K., Isaka S., Watanabe T.X., Ohkura S., Tomikawa J., Maeda K.I., Tsukamura H.
Journal of Reproduction and Development Vol. 55 page： 378-382 2009
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Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats Reviewed
Ohkura, S.Uenoyama, Y.Yamada, S.Homma, T.Takase, K.Inoue, N.Maeda, K. I.Tsukamura, H.
Peptides Vol. 30 page： 49-56 2009
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Food deprivation induces monocarboxylate transporter 2 expression in the brainstem of female rat Reviewed
Matsuyama, S.Ohkura, S.Iwata, K.Uenoyama, Y.Tsukamura, H.Maeda, K. I.Kimura, K.
J Reprod Dev Vol. 55 page： 256-261 2009
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Kisspeptin/metastin: A key molecule controlling two modes of gonadotrophin-releasing hormone/luteinising hormone release in female rats
Uenoyama Y, Tsukamura H, Maeda KI
J Neuroendocrinol Vol. 21 page： 299 - 304 2009
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Gonadotrophin-Releasing Hormone Pulse Generator Activity in the Hypothalamus of the Goat Reviewed
Ohkura S., Takase K., Matsuyama S., Mogi K., Ichimaru T., Wakabayashi Y., Uenoyama Y., Mori Y., Steiner R.A., Tsukamura H., Maeda K.I, Okamura H.
Journal of Neuroendocrinology Vol. 21 page： 813-821 2009
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Possible role of oestrogen in pubertal increase of Kiss1/kisspeptin expression in discrete hypothalamic areas of female rats Reviewed
Takase K, Uenoyama Y, Inoue N, Matsui H, Yamada S, Shimizu M, Homma T, Tomikawa J, Kanda S, Matsumoto H, Oka Y, Tsukamura H, Maeda KI
Journal of Neuroendocrinology Vol. 21 page： 527-537 2009
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Central lipoprivation-induced suppression of luteinizing hormone pulses is mediated by paraventricular catecholaminergic inputs in female rats Reviewed
Sajapitak S, Iwata K, Shahab M, Uenoyama Y, Yamada S, Kinoshita M, Bari FY, I'Anson H, Tsukamura H, Maeda K.
Endocrinology Vol. 149 page： 3016-24 2008
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Paraventricular α1- and α2-adrenergic receptors mediate hindbrain lipoprivation-induced suppression of luteinizing hormone pulses in female rats
Sajapitak S, Uenoyama Y, Yamada S, Kinoshita M, Iwata K, Bari FY, I'Anson H, Tsukamula H, Maeda KI
J Reprod Dev Vol. 54 page： 198-202 2008
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Oestrogen-dependent stimulation of luteinising hormone release by galanin-like peptide in female rats Reviewed
Uenoyama Y, Tsukamura H, Kinoshita M, Yamada S, Iwata K, Pheng V, Sajapitak S, Sakakibara M, Ohtaki T, Matsumoto H, Maeda KI
J Neuroendocrinol Vol. 20 page： 626-31 2008
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Inhibition of Metastin (Kisspeptin-54)-GPR 54 Signaling in the Arcuate Nucleus-Median Eminence Region during Lactation in Rats. Reviewed
Yamada S, Uenoyama Y, Kinoshita M, Iwata K, Takase K, Matsui H, Adachi S, Inoue K, Maeda KI, Tsukamura H.
Endocrinology Vol. 148 page： 2226-2232 2007
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Involvement of Anteroventral Periventricular Metastin/Kisspeptin Neurons in Estrogen Positive Feedback Action on Luteinizing Hormone Release in Female Rats
Adachi, S., Yamada, S., Takatsu, Y., Matsui, H., Kinoshita, M., Takase, K., Sugiura, H., Ohtaki, T., Matsumoto, H., Uenoyama, Y., Tsukamura, H., Inoue, K., and Maeda, K.
Journal of Reproduction and Development Vol. 53 page： 367-378 2007
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Acute Lipoprivation Suppresses Pulsatile Luteinizing Hormone Secretion without Affecting Food Intake in Female Rats
Shahab,M., Sajapitak, S., Tsukamura H., Kinoshita M., Matsuyama S., Ohkura S., Yamada S., Uenoyama Y., I'Anson, H., and Maeda K.-I.
Journal of Reproduction and Development Vol. 52 page： 763-772 2006
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Role of Noradrenergic Receptors in the Bed Nucleus of the Stria Terminalis in Regulating Pulsatile Leteinizing Hormone Secretion in Female Rats
Yamada, S., Uenoyama, Y., Maeda, K.-I., and Tsukamura, H.
Journal of Reproduction and Development Vol. 52 page： 115-121 2006
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Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats
Kinoshita, M., Tsukamura, H., Adachi, S., Matsui, H., Uenoyama, Y., Iwata, K., Yamada, S., Inoue, K., Ohtaki, T., Matsumoto, H., and Maeda, K.-I.
Endocrinology Vol. 146 page： 4431-4436 2005
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Involvement of brainstem catecholaminergic inputs to the hypothalamic paraventricular nucleus in estrogen receptorα expression in this nucleus during different stress conditions in female rats
Estacio, M., A., C., Tsukamura, H., Reyes, B., A., S., Uenoyama, Y., I'Anson, H. and Maeda, K.-I.
Endocrinology Vol. 145 page： 4917-4926 2004
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The lipoxygenase pathway are involved in LH-stimulated progesterone production in bovine corpus luteum
Taniguchi, H., Uenoyama, Y., Miyamoto, Y. and Okuda, K
Prostaglandins and other lipid mediators Vol. 67 page： 49-60 2002.6
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Prepubertal Changes in Immunoreactive Inhibin Concentration in Blood Serum and Testicular Tissue in Holstein Bull Calves
Matsuzaki S, Uenoyama Y, Okuda K, Watanabe G, Kitamura N, Taya K, Cruzana MBC, Yamada J
J Vet Med Sci Vol. 63 page： 1303-1307 2001.12
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Estradiol-17b Is Produced in Bovine Corpus Luteum
Okuda K, Uenoyama Y, Berisha B, Lange IG, Taniguchi H, Kobayashi S, Kobayashi S-I, Miyamoto A, and Schams D
Biol Reprod Vol. 65 page： 1634-1639 2001.12
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Age-related changes in the serum levels of inhibin, FSH, LH and testosterone in Holstein bulls. Reviewed
Matsuzaki S, Uenoyama Y, Okuda K, Watanabe G, Kitamura N, Taya K, Yamada J.
J Reprod Dev Vol. 46 page： 245-248 2000.8
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Basic fibroblast growth factor-induced prostaglansin production and its intracellular mechanisms in cultured bovine luteal cells
Uenoyama Y, Murakami S, Schams D, Okuda K
J Reprod Dev Vol. 46 page： 93-99 2000.4
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Luteinizing hormone receptors in the bovine corpus luteum during the oestrous cycle and pregnancy
Okuda K, Uenoyama Y, Naito C, Sakabe Y, Kawate N
Reprod Fertil Dev Vol. 11 page： 147-151 1999.11
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Tumor necrosis factor a receptors in microvascular endothelial cells from bovine corpus luteum
Okuda K, Sakumoto R, Uenoyama Y, Berisha B, Miyamoto A, Schams D
Biol Reprod Vol. 61 page： 1017-1022 1999.10
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Noradrenaline stimulates the secretion of prostaglandin F2a in cultured endometrial cells
Skarzynski DJ, Uenoyama Y, Kotwica J, Okuda K
Biol Reprod Vol. 60 page： 277-282 1999.2
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Secretion of prostaglandins E2 and F2a by bovine endometrium in response to oxytocin during the estrous cycle
Miyamoto Y, Skarzynski DJ, Uenoyama Y, Okuda K
J Reprod Dev Vol. 44 page： 289-295 1998.8
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Progesterone stimulation by prostaglandin F2a involves the protein kinase C pathway in cultured bovine luteal cells
Okuda K, Uenoyama Y, Lee KW, Sakumoto R, Skarzynski DJ
J Reprod Dev Vol. 44 page： 79-84 1998.4
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Oxytocin receptors and their physiological significance in the ovary
Okuda K, Uenoyama Y
Reproductive Biology Update -Novel Tools for Assessment of Environmental Toxicity- page： 297-304 1998.1
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Up-regulation of oxytocin receptors in porcine endometrium by adenosine 3',5'-monophosphate
Uenoyama Y, Hattori S, Miyake M, Okuda K
Biol Reprod Vol. 57 page： 723-728 1997.10
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Regulation of oxytocin receptors in bovine granulosa cells.
Uenoyama Y, Okuda K
Biol Reprod Vol. 57(3) page： 569-574 1997.9
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Functional oxytocin receptors in bovine granulosa cells
Okuda K, Uenoyama Y, Fujita Y, Iga K, Sakamoto K, Kimura T
Biol Reprod Vol. 56(3) page： 625-631 1997.3
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Effects of prostaglandins and oestradiol-17b on oxytocin binding in cultured bovine luteal cells
Okuda K, Uenoyama Y, Miyamoto A, Okano A, Schweigert FJ, Schams D.
Reprod Fertil Dev Vol. 7(5) page： 1045-1051 1995.10
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Epidermal growth factor and its receptor in bovine corpus luteum during the estrous cycle Reviewed
Okuda K, Uenoyama Y, Hwang KN, Yamada J, Wakabayashi K
J Reprod Dev Vol. 40 page： 349-54 1994