Papers - AIBA Hirofumi
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Novel TORC1 inhibitor Ecl1 is regulated by phosphorylation in fission yeast Reviewed
Ohtsuka, H., Kawai, S., Ito, Y., Kato, Y., Shimasaki, T., Imada, K., Otsubo, Y., Yamashita, A., Mishiro-Sato, E., Kuwata, K., and Aiba, H.
Aging Cell 2025.2
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Characterization of P-type H+-ATPase Pma1 inhibitors that extend chronological lifespan in fission yeast. Reviewed
Tamura, M., Yamashita, W., Hibi, T., Inui, S., Tanaka, K., Ozako, M., Shimasaki, T., Ohtsuka, H., Shibuya, M., Yamamoto, Y., Yokoshima, S., and Aiba, H.
Molecular Genetics and Genomics 2025
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Low-molecular weight compounds that extend the chronological lifespan of yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe Reviewed
Ohtsuka, H., Shimasaki, T., and Aiba, H.
Advanced Biology 2024
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A novel transcription factor Sdr1 involving sulfur depletion response in fission yeast. Reviewed
Ohtsuka, H., Ohara, K., Shimasaki, T., Hatta, Y., Maekawa, Y., and Aiba, H.
Genes to Cells Vol. 29 page： 667 - 680 2024
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Identification of plb1 mutation that extends longevity via activating Sty1 MAPK in Schizosaccharomyces pombe. Reviewed
Maekawa, Y., Matsui, K., Okamoto, K., Shimasaki, T., Ohtsuka, H., Tani, M., Ihara, K., and Aiba, H.
Molecular Genetics and Genomics Vol. 299 2023.12
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The ecl family gene ecl3+ is induced by phosphate starvation and contributes to sexual differentiation in fission yeast Reviewed
Ohtsuka, H., Sakata, H., Kitazaki, Y., Tada, M., Shimasaki, T., Otsubo, Y., Maekawa, Y., Kobayashi, M., Imada, K., Yamashita, A., and Aiba, H.
Journal of Cell Science 2023
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A critical role of the periplasm in copper homeostasis in Gram-negative bacteria. Reviewed
Ishihara, J., Mekubo, T., Kusaka, C., Kondo, S., Aiba, H., Ishikawa, S., Ogasawara, N., Oshima, T., and Takahashi, H.
BioSystems Vol. 231 page： 104980 2023
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ecl family genes: Factors linking starvation and lifespan extension in Schizosaccharomyces pombe. Reviewed
Ohtsuka, H., Otsubo, Y., Shimasaki, T., Yamashita, A., and Aiba, H.
Molecular Microbiology Vol. in press 2023
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Metarhizium robertsii COH1 functionally complements Schizosaccharomyces pombe Ecl family proteins. Reviewed
Ohtsuka, H., Kawai S, Otsubo, Y., Shimasaki, T., Yamashita, A., and Aiba, H.
The Journal of General and Applied Microbiology 2023
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Characterization of hexose transporter genes in the views of the chronological life span and glucose uptake in fission yeast Reviewed
Maruyama, T., Hayashi, K., Matsui, K., Maekawa, Y., Shimasaki, T., Ohtsuka, H., Saitoh, S., and Aiba, H.
The Journal of General and Applied Microbiology 2022.7
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Response to leucine in Schizosaccharomyces pombe (fission yeast).(Review)
Ohtsuka, H., Shimasaki, T., and Aiba, H.
FEMS YEAST RESEARCH Vol. 22 ( 1 ) 2022.4
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Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast. Reviewed
Ohtsuka, H., Matsumoto, T., Mochida, T., Shimasaki, T., Shibuya, M., Yamamoto, Y., and Aiba, H.
Biosci. Biotech. Biochem. 2022
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Cdc13 (cyclin B) is degraded by autophagy under sulfur depletion in fission yeast. Reviewed
Ohtsuka, H., Hatta, Y., Hayashi, K., Shimasaki, T., Otsubo,Y., Ito, Y., Tsutsui, Y., Hattori, N., Yamashita, A., Murakami, H., and Aiba, H.
Autophagy Reports 2022
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Sporulation: a response to starvation in the fission yeast Schizosaccharomyces pombe. (Review) Reviewed
Ohtsuka, H., Imada, K., Shimasaki, T., and Aiba, H.
MicrobiologyOpen 2022
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Extension of chronological lifespan in Schizosaccharomyces pombe. (Review) Reviewed
Ohtsuka, H., Shimasaki, T., and Aiba, H.
Genes to Cells 2021
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Genes affecting the extension of chronological lifespan in Schizosaccharomyces pombe (fission yeast). (Review) Reviewed
Ohtsuka, H., Shimasaki, T., and Aiba, H.
Molecular Microbiology Vol. 115 ( 4 ) page： 623 - 642 2021
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Magnesium depletion extends fission yeast lifespan via general amino acid control activation. Reviewed
Ohtsuka, H., Kobayashi, M., Shimasaki, T., Sato, T., Akanuma, G., Kitaura, Y., Otsubo, Y., Yamashita, A., and Aiba, H.
MicrobiologyOpen Vol. 10:e1176 ( 10:e1176 ) 2021
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Identification of sur2 mutation affecting the lifespan of fission yeast. Reviewed
Kurauchi, T. *, Matsui, K. *, Shimasaki, T., Ohtsuka, H., Tsubouchi, S., Ihara, K., Tani, M., and Aiba, H.
FEMS Microbiology Letters Vol. fnab070 2021
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Response to sulfur in Schizosaccharomyces pombe. (Review) Reviewed
Ohtsuka, H., Shimasaki, T., and Aiba, H.
FEMS Yeast Research 2021
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Identification of ksg1 mutation showing long-lived phenotype in fission yeast. Reviewed
Matsui, K., Okamoto, K., Hasegawa, T., Ohtsuka, H., Shimasaki, T., Ihara, K., Goto, Y., Aoki, K., and Aiba, H.
Genes to Cells 2021
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gas1 mutation extends chronological lifespan via Pmk1 and Sty1 MAPKs in Schizosaccharomyces pombe Reviewed
Imai, Y.*, Shimasaki, T.*, Enokimura, C., Ohtsuka, H., Tsubouchi, S., Ihara, K., and Aiba, H.
Biosci. Biotech. Biochem. Vol. 84 page： 330-337 2020
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Sulfur depletion induces autophagy through Ecl1 family genes in fission yeast. Reviewed
Shimasaki, T., Okamoto, K., Ohtsuka, H., and Aiba, H.
Genes to Cells Vol. 25 page： 825-830 2020
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Leucine depletion extends the lifespans of leucine-auxotrophic fission yeast by inducing Ecl1 family genes via the transcription factor Fil1 Reviewed
Ohtsuka, H*. Kato, T*, Sato, T., Shimasaki, T., Kojima, T., and Aiba, H.
Mol. Genet. Genomics Vol. 294 page： 1499-1509 2019
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Tschimganine and its derivatives extend the chronological life span of yeast via activation of the Sty1 pathway Reviewed
Hibi, T.*, Ohtsuka, H.*, Shimasaki, T., Inui, S., Shibuya, M., Tatsukawa, H., Kanie, K., Yamamoto, Y., and Aiba, H.
Genes to Cells Vol. 23 page： 620-637 2018
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Construction of a photo-responsive chimeric histidine kinase in Escherichia coli. Reviewed
Hori, M.*, Oka, S*., Sugie, Y., Ohtsuka, H. and Aiba, H.
J. Gen. Appl. Microbiol. Vol. 63 page： 44-50 2017
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Identification of a novel protein kinase that affects on the chronological lifespan in fission yeast Reviewed
Kurauchi, T.*, Hashizume, A.*, Imai, Y., Hayashi, K., Tsubouchi, S., Ihara, K., Ohtsuka, H., and Aiba, H.
FEMS Microbiology Letters Vol. 364 page： fnw257 2017
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Ecl1 is a zinc-binding protein involved in the zinc-limitation-dependent extension of chronological lifespan in fission yeast Reviewed
Shimasaki, T., Ohtsuka, H., Naito, C., Azuma, K., Tenno, T., Hiroaki, H., Murakami, H., and Aiba, H.
Mol. Genet. Genomics Vol. 292 ( 2 ) page： 475-481 2017
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Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome. Reviewed
Ohtsuka, H.*, Takinami, M.*, Shimasaki, T., Hibi, T., Murakami, H., and Aiba, H.
Molecular Microbiology Vol. 105 page： 84-97 2017
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Factors extending the chronological lifespan of yeast: Ecl1 family genes (Review). Reviewed
Ohtsuka, H., and Aiba, H.
FEMS Yeast Research 2017
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Reconstruction of a chromatic response system in Escherichia coli. Reviewed
Sugie, Y.*, Hori, M.*, Oka, S., Ohtsuka, H. and Aiba, H.
J. Gen. Appl. Microbiol. Vol. 62 page： 140-143 2016
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Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes Reviewed
Ohtsuka, H.*, Ishida, M.*, Naito, C., Murakami, H. and Aiba, H.
Mol. Genet. Genomics Vol. 290 ( 1 ) page： 173-185 2015
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腹八分目はサルでも寿命を延ばす！？「腹八分目に医者いらず」を実証するアカゲザルを用いた食餌制限研究 Reviewed
島崎嵩史、饗場浩文
化学と生物 Vol. 53 ( 7 ) page： 426-428 2015
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A new pma1 mutation identified in a chronologically long-lived fission yeast mutant Reviewed
Naito, C., Ito, H., Oshiro., Ohtsuka, H., Murakami, H. and Aiba, H.
FEBS Open Bio Vol. 4 page： 829-833 2014
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Ecl1 is activated by the transcription factor Atf1 in response to H2O2 stress in Schizosaccharomyces pombe. Reviewed
Shimasaki, T. *, Ohtsuka, H. *, Naito, C., Murakami, H. and Aiba, H.
Mol. Genet. Genomics Vol. 289 ( 4 ) page： 685-693 2014
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Regulation of wee1+ expression during meiosis in fission yeast. Reviewed
Murakami-Tonami, Y., Ohtsuka, H., Aiba, H. and Murakami, H.
Cell Cycle Vol. 13 ( 18 ) page： 2853-2858 2014
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The fission yeast php2 mutant displays a lengthened chronological lifespan Reviewed
Takuma, K. *, Ohtsuka, H. *, Azuma, K., Murakami, H. and Aiba, H.
Biosci. Biotech. Biochem. Vol. 77 ( 7 ) page： 1548-1555 2013
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Screening for long-lived genes identifies Oga1, a guanine-quadruplex associated protein that affects the chronological lifespan of the fission yeast Schizosaccharomyces pombe. Reviewed
Ohtsuka, H. *, Ogawa, S. *, Kawamura, H., Sakai, E., Ichinose, K., Murakami, H. and Aiba, H.
Mol. Genet. Genomics Vol. 288 ( 5 ) page： 285-295 2013
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Another way to induce synchronous meiosis Invited Reviewed
Murakami, H. and Aiba, H.
Cell Cycle Vol. 11 ( 10 ) page： 1874-1875 2012.5
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分裂酵母を用いた経時寿命制御因子の探索と機能解析
饗場浩文, 大塚北斗
化学と生物 Vol. 50 ( 5 ) page： 337-344 2012.5
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Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast. Reviewed
Ohtsuka, H., Azuma, K., Kubota, S., Murakami, H., Giga-Hama, Y., Tohda, H. and Aiba, H.
Genes to Cells Vol. 17 ( 1 ) page： 39-52 2012.1
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Extension of chronological lifespan by ScEcl1 depends on mitochondria in Saccharomyces cerevisiae Reviewed
Azuma, K., Ohtsuka, H., Murakami, H. and Aiba, H.
Biosci. Biotech. Biochem. Vol. 76 ( 10 ) page： 1938-1942 2012
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Ecl1, a regulator of chronological lifespan of Schizosaccharomyces pombe is induced upon nitrogen starvation Reviewed
Miwa, Y., Ohtsuka, H., Naito, C., Murakami, H. and *Aiba, H.
Biosci. Biotech. Biochem. Vol. 75 ( 2 ) page： 279-283 2011.2
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hsf1+ extends chronological lifespan through Ecl1 family genes in fission yeast. Reviewed
Ohtsuka, H., Azuma, K., Murakami, H., and *Aiba, H.
Molecular Genetics and Genomics Vol. 285 ( 1 ) page： 67-77 2011.1
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Regulation of yeast forkhead transcription factors and FoxM1 by cyclin-dependent and Polo-like kinases
Murakami, H., Aiba, H., Nakanishi, M., and Murakami-Tonami, Y.
Cell Cycle Vol. 9 page： 3233-3242 2010
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Pma1, a P-type proton ATPase, is a determinant of chronological lifespan in fission yeast Reviewed
Ito, H., Oshiro, T., Fujita, Y., Kubota, S., Naito, C., Ohtsuka, H., Murakami, H., and *Aiba, H.
J. Biol. Chem. Vol. 285 ( 45 ) page： 34616-34620 2010
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Identification and characterization of an Ecl1-family gene in Saccharomyces cerevisiae. Reviewed
Azuma, K., Ohtsuka, H., Mita, S., Murakami, H., and *Aiba, H.
Biosci. Biotech. Biochem. Vol. 73 page： 2787-2789 2009.12
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The implication of YggT of Escherichia coli in osmotic regulation. Reviewed
Ito. T., Uozumi, N., Nakamura, T., Takayama, S., Matsuda, N., Aiba, H., Hemmi, H., and Yoshimura, T.
Biosci. Biotech. Biochem. Vol. 73 page： 2698-2704 2009.12
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Identification of Ecl family genes that extend chronological lifespan in fission yeast Reviewed
Ohtsuka, H., Ogawa, Y., Mizuno H., Mita, S., and *Aiba, H.
Biosci. Biotech. Biochem. Vol. 73 page： 885-889 2009
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Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast. Reviewed
Shimada, M., Yamamoto, A., Murakami-Tonami, Y., Nakanishi, M., Yoshida, T., Aiba, H., and Murakami, H.
Biochem. Biophy. Res. Com. Vol. 388 ( 3 ) page： 529-532 2009
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A novel gene, ecl1+, extends chronological lifespan in fission yeast. Reviewed
Ohtsuka, H., Mita, S., Ogawa, Y., Azuma, K., Ito, H and *Aiba, H.
FEMS Yeast Research Vol. 8 page： 520-530 2008
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Identification of a fatty acyl-CoA synthetase gene, lcf2+, which affect viability after entry into the stationary phase in Schizosaccharomyces pombe. Reviewed
Fujita, Y., Mita, S., Ohtsuka, H., and *Aiba, H.
Biosci. Biotech. Biochem. Vol. 71 ( 12 ) page： 3041-3047 2007
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Effect of the arcA Mutation on the Expression of Flagella Genes in Escherichia coli. Reviewed
Kato Y, Sugiura M, Mizuno T, *Aiba H.
Biosci Biotechnol Biochem. Vol. 71 page： 77-83 2007
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Transcription factor distribution in Escherichia coli: studies with FNR protein. Reviewed
Grainger DC, Aiba H, Hurd D, Browning DF, Busby SJ.
Nucleic Acids Res. Vol. 35 page： 269-278 2007
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大腸菌のタイリングアレイ解析により明らかになったゲノム進化
大島拓、小笠原直毅、石川周、黒川顕、饗場浩文
日本細菌学雑誌 Vol. 62 ( 1 ) page： 46 2007
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Escherichia coli histone-like protein H-NS preferentially binds to horizontally acquired DNA in association with RNA polymerase. Reviewed
Oshima, T., Ishikawa, S., Kurokawa, K., Aiba, H., and Ogasawara, N.
DNA Research Vol. 13 page： 141-153 2006
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Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli. Reviewed
Yamamoto, K., Hirao, K., Oshima, T., Aiba, H., Utsumi, R., and Ishihama, A.
J. Biol. Chem. Vol. 280 page： 1448-1456 2005
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モデル細菌のシステマチックなゲノム機能研究
小笠原直毅 藤田泰太郎 饗場浩文 加藤潤一 大森正之 鈴木岩根
蛋白質 核酸 酵素 Vol. 50 page： 2191-2197 2005
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赤ワインを飲んで長生きを! Invited
饗場浩文
化学と生物 Vol. 42 page： 114-115 2004
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分裂酵母における胞子形成制御するHis-Aspリン酸リレー情報伝達 Invited
中道範人,山田寿美,青山桂輔,大宮隆祐,饗場浩文,水野猛
日本農芸化学会誌 Vol. 78 page： 50-51 2004
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A defect in a fatty acyl-CoA synthetase gene, lcf1+, results in a decrease in viability after entry into the stationary phase in fission yeast. Reviewed
Oshiro, T., *Aiba, H., and Mizuno, T.
Mol. Genet. Genomics Vol. 269 page： 437-442 2003
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Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
Hagiwara, D., Sugiura, M., Oshima, T., Mori, H., Aiba, H., Yamashino, T., and Mizuno, T.
J. Bacteriol. Vol. 185 page： 5735-5746 2003
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Characterization of the Prr1 response regulator with special reference to sexual development in Schizosaccharomyces pombe. Reviewed
Nakamichi, N., Yamada, H., Aiba, H., Aoyama, K., Ohmiya, R., and Mizuno, T.
Biosci. Biotech. Biochem. Vol. 67 ( 3 ) page： 547-555 2003
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Identification and classification of two-component systems that affect rpoS expression in Escherichia coli. Reviewed
Sugiura, M., *Aiba, H., and Mizuno, T.
Biosci. Biotech. Biochem. Vol. 67 ( 7 ) page： 1612-1615 2003
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Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12. Reviewed
Oshima, T., *Aiba, H., Masuda, Y., Kanaya, S., Sugiura, M., Wanner, B. L., Mori, H., and Mizuno, T.
Mol. Microbiol. Vol. 46 page： 281-291 2002
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His-to-Asp phosphorelay circuitry for regulation of sexual development in Schizosaccharomyces pombe. Reviewed
Nakamichi, N., Yamada, H., Aoyama, K., Ohmiya, R., Aiba, H., and Mizuno, T.
Biosci. Biotech. Biochem. Vol. 66 ( 12 ) page： 2663-2672 2002
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大腸菌におけるポストゲノムシーケンス解析 Invited
森浩禎,金谷重彦,饗場浩文,大島拓,増田泰
化学と生物 Vol. 40 page： 469-479 2002
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A novel feature of the multistep phosphorelay in Escherichia coli: a revised model of the RcsC --> YojN --> RcsB signalling pathway implicated in capsular synthesis and swarming behaviour. Reviewed
Takeda, S., Fujisawa, Y., Matsubara, M., Aiba, H., and Mizuno, T.
Mol. Microbiol. Vol. 40 page： 440-450 2001
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The Arabidopsis sensor His-kinase, AHK4, can respond to cytokinins Reviewed
Suzuki, T., Miwa, K., Ishikawa, K., Yamada, H., Aiba, H., and Mizuno, T.
Plant Cell Physiol. Vol. 42 ( 2 ) page： 107-113 2001
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Genetic analysis of the His-to-Asp phosphorelay implicated in mitotic cell cycle control: Involvement of histidine-kinase genes of Schizosaccharomyces pombe. Reviewed
Aoyama, K., *Aiba, H., and Mizuno, T.
Biosci. Biotech. Biochem. Vol. 65 ( 10 ) page： 2347-2352 2001
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Spy1, a histidine-containing phosphotransfer signaling protein, regulates the fission yeast cell cycle through the Mcs4 response regulator. Reviewed
Aoyama, K., Mitsubayashi, Y., *Aiba, H., and Mizuno, T.
J. Bacteriol. Vol. 182 page： 4868-4874 2000
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The Prr1 response regulator is essential for transcription of ste11+ and for sexual development in fission yeast. Reviewed
Ohmiya, R., Yamada, H., Kato, C., Aiba, H., and Mizuno, T.
Mol. Gen. Genet. Vol. 264 page： 441-451 2000
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Identification and characterization of a novel gene, hos2+, the function of which is necessary for growth under high osmotic stress in fission yeast. Reviewed
Nakamichi, N., Yamamoto, E., Yamada, H., *Aiba, H., and Mizuno, T.
Biosci. Biotech. Biochem. Vol. 64 page： 2493-2496 2000
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Identification and characterization of a novel gene, hos3+, the function of which is necessary for growth under high osmotic stress in fission yeast. Reviewed
Aoyama, K., Kawaura, R., Yamada, H., *Aiba, H., and Mizuno, T.
Biosci. Biotech. Biochem. Vol. 64 page： 1099-1102 2000
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Isolation of multicopy suppressors of the calcium sensitivity of a mutant lacking the bZIP transcription factor Atf1 in fission yeast. Reviewed
Ohmiya, R., Kato, C., Yamada, H., Aiba, H., and Mizuno, T.
Mol. Gen. Genet. Vol. 261 page： 297-306 1999
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The cta3+ gene that encodes a cation-transporting P-type ATPase is induced by salt stress under control of the Wisl-Styl MAPKK-MAPK cascade in fission yeast. Reviewed
Nishikawa, T., *Aiba, H., and Mizuno, T.
FEBS Lett. Vol. 455 page： 183-187 1999
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A fission yeast gene(prrl+)that encodes a response regulator implicated in oxidative stress response. Reviewed
Ohmiya, R., Kato, C., Yamada, H., Aiba, H., and Mizuno, T.
J. Biochem Vol. 125 page： 1061-1066 1999
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Isolation and characterization of high osmolarity sensitive mutants of fission yeast. Reviewed
*Aiba, H., Kawaura, R., Yamamoto, E., Yamada, H., Takegawa, K., and Mizuno, T.
J. Bacteriol. Vol. 180 page： 5038-5043 1998
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Phosphate-uptake behaviour of a mutant of Synechococcus sp. PCC7942 lacking one protein of the high-affinity phosphate-uptake system. Reviewed
Falkner, R., Wagner, F., Aiba, H., and Falkner, G.
Planta Vol. 206 page： 461-465 1998
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Clarification of the promoter structure of the osmoregulated gpd1+ gene encoding an isozyme of NADH-dependent glycerol-3-phosphate dehydrogenase in fission yeast Reviewed
Ohmiya, R., Aiba, H., Yamada, H., and Mizuno, T.
Biosci. Biotech. Biochem. Vol. 61 ( 3 ) page： 553-555 1997
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Characterization of multicopy suppressor genes that complement a defect in the Wis1-Sty1 MAP kinase cascade involved in stress responses in Shizosaccharomyces pombe Reviewed
Yamada, H., Ohmiya, R., Yamamoto, E., Aiba, H., and Mizuno, T.
J. Gen. Appl. Microbiol. Vol. 43 page： 209-215 1997
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A cyanobacterial gene that interferes with the phosphotransfer signal transduction involved in the osmoregulatory expression of ompC and ompF in Escherichia coli Reviewed
Hirokawa, K., Nagaya, M., Aiba, H., and Mizuno, T.
Biosci. Biotech. Biochem. Vol. 60 ( 2 ) page： 277-283 1996
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微生物の環境応答とタンパク質リン酸化反応を介した情報伝達機構
日本農芸化学会誌 Vol. 70 ( 10 ) page： 1079-1085 1996
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Construction and characterization of a deletion mutant of gpd2 that encodes an isozyme of NADH-dependent glycerol-3-phosphate dehydrogenase in fission yeast Reviewed
Yamada, H., Ohmiya, R., Aiba, H., and Mizuno, T.
Biosci. Biotech. Biochem. Vol. 60 ( 5 ) page： 918-920 1996
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浸透圧ストレスへの応答とシグナル伝達 Reviewed
現代化学増刊30植物のシグナルトランスダクション page： 81-87 1996
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SomA, a novel gene that encodes a major outermembrane protein of Synechococcus sp. PCC7942 Reviewed
Umeda, H., Aiba, H., and Mizuno, T.
Microbiology Vol. 142 page： 2121-2128 1996
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Suppressor mutations in α-subunit of RNA polymerase for a mutant of the positive regulator, OmpR, in Escherichia coli Reviewed
Kato, N., Aiba, H., and Mizuno, T.
FEMS Microbiology Letters Vol. 139 page： 175-180 1996
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微生物の環境応答におけるタンパク質リン酸化反応を介した情報伝達機構の発見
日本農芸化学会誌 Vol. 70 page： 451-453 1996
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Adaptive responses and signal transduction in bacteria
Vol. 51 ( 2 ) page： 549-557 1996
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A novel gene that interferes with the phosphotransfer signal transduction mediated by the EnvZ osmosensor in Escherichia coli Reviewed
Hirokawa, K., Ogino, T., Aiba, H., and Mizuno, T.
Biosci. Biotech. Biochem. Vol. 60 ( 10 ) page： 1681-1685 1996
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General facet and molecular basis of bacterial signal transduction.
Protein, Nucleic acid and Enzyme Vol. 40 ( 8 ) page： 1000-1009 1995
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Gene activation by the Escherichia coli positive regulator OmpR : a mutational study of the DNA-binding domain of OmpR Reviewed
Kato, N., Tsuzuki, M., Aiba, H., and Mizuno, T.
Mol. Gen. Genet Vol. 248 page： 399-406 1995
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The osmo-inducible gpdl+ gene is a target of the signaling pathway involving Wis1 MAP-kinase kinase in fission yeast Reviewed
*Aiba, H., Yamada, H., Ohmiya, R., and Mizuno, T.
FEBS Letters Vol. 376 page： 199-201 1995
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Osmoregulation of fission yeast : cloning of two distinct genes encoding glycerol-3-phosphate dehydrogenase, one of which is responsible for osmotolerance for growth Reviewed
Ohmiya, R., Yamada, H., Nakashima, K., Aiba, H., and Mizuno, T.
Molecular Microbiology Vol. 18 ( 5 ) page： 963-973 1995
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The SphR product, a two-component System response regulator protein, regulates phosphate assimilation in Synechococcus sp. Strain PCC7942 by bounding to two sites upstream from the phoA promoter. Reviewed
Nagaya, M., Aiba, H., and Mizuno, T.
Journal of Bacteriology Vol. 176 ( 8 ) page： 2210-2215 1994
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Mechanism of gene activation by the Escherichia coli positive regulator, OmpR : a mutant defective in transcriptional activation. Reviewed
*Aiba, H., Kato, N., Tsuzuki, M., and Mizuno, T.
FEBS Letters Vol. 351 page： 303-307 1994
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A novel gene whose expression in regulated by the response-regulator, SphR, in response to phosphate limitation in Synechococcus species PCC7942. Reviewed
*Aiba, H., and Mizuno, T.
Molecular Microbiology Vol. 13 ( 1 ) page： 25-34 1994
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Gene activation by the Escherichia coli positive regulator, OmpR : Phosphorylation-independent mechanism of activation by an OmpR mutant. Reviewed
Tsuzuki, M., Aiba, H., and Mizuno, T.
J. Mol. Biol. Vol. 242 page： 607-613 1994
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Sensor and regulator proteins from the cyanobacterium Synechococcus species PCC7942 that belong to the bacterial signal-transduction protein families : implication in the adaptive response to phosphate limitation Reviewed
*Aiba, H., Nagaya, M., and Mizuno, T.
Molecular Microbiology Vol. 8 ( 1 ) page： 81-91 1993
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Cloning of a sensory-kinase-encoding gene that belongs to the two-component regulatory family from the cyonobacterium Synechococcus sp. PCC7942 Reviewed
Nagaya, M., Aiba, H., and Mizuno, T.
Gene Vol. 131 page： 119-124 1993
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Adeptive response in cyanobacteria
Bioscience and Biotechnology Vol. 31 ( 6 ) page： 355-357 1993
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Osmoregulation of the fatty acid receptor gene fadL in Escherichia coli Reviewed
Higashitani, A., Nishimura, Y., Hara, H., Aiba, H., Mizuno, T., and Horiuchi, K.
Molecular & General Genetics Vol. 240 page： 339-347 1993
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A cyanobacterial gene encoding a protein with extensive homology to mammalian phosphoribosylpyrophosphate synthetase Reviewed
Nagaya, M., Aiba, H., and Mizuno, T.
Bioscience, Biotechnology, and Biochemistry Vol. 57 ( 11 ) page： 1958-1959 1993
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A novel sensor - regulator protein that belongs to the homologous family of signal-transduction proteins involved in adaptive responses in Escherichia coli. Reviewed
Nagasawa, S., Tokishita, S., Aiba, H., and Mizuno, T.
Molecular Microbiology Vol. 6 ( 6 ) page： 799-807 1992
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Signal transduction and osmoregulation in Escherichia coli : A novel type of mutation in the phosphorylation domain of the activator protein, OmpR, results in a defect in its phosphorylatin-dependent DNA binding Reviewed
Nakashima, K., Kanamaru, K., Aiba, H., and Mizuno, T.
J. Biol. Chem. Vol. 266 ( 17 ) page： 10775-10780 1991
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Osmoregulatory expression of the porin genes in Escherichia coli : evidence for signal titration in the signal transduction through EnvZ-OmpR phosphotransfer. Reviewed
Nakashima, K., Kanamaru, K., Aiba, H., and Mizuno, T.
FEMS Microbiology Letters Vol. 82 page： 43-48 1991
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Functional map of the α subunit of Escherichia coli RNA polymerase : two modes of transcription activation by positive factors Reviewed
Proceedings of the National Academy of Sciences Vol. 88 page： 8958-8962 1991
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Transmembrane signal transduction and osmoregulation in Escherichia coli. functional importance of the periplasmic domain of the membrane-located protein kinase, EnvZ Reviewed
Tokishita, S., Kojima, A., Aiba, H., and Mizuno, T.
The Journal of Biological Chemistry Vol. 266 ( 11 ) page： 6780-6785 1991
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Protein phosphorylation and signal transduction in bacteria
Protein, Nucleic acid and Enzyme Vol. 35 page： 1537-1549 1990
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Transmembrane signal transduction and osmoregulation in Escherichia coli : II the osmotic sensor, EnvZ, located in the isolated cytoplasmic membrane displays its phosphorylationand dephosphorylation abilities as to the activator protein, OmpR Reviewed
Tokishita, S., Yamada, H., Aiba, H., and Mizuno, T.
The Journal of Biochemistry Vol. 108 page： 488-493 1990
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Phosphorylation of a bacterial activator protein, OmpR, by a protein kinase, EnvZ, stimulates the transcription of the ompF and ompC genes in Escherichia coli Reviewed
Aiba, H., and Mizuno, T.
FEBS Lett. Vol. 261 ( 1 ) page： 19-22 1990
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Transmembrane signal transduction and osmoreguletion in Escherichia coli : I analysis by site-directed mutagenesis of the amino acid residues involved in phosphotransfer between the two regulatory comporents, EnvZ and OmpR Reviewed
Kanamaru, K., Aiba, H., and Mizuno, T.
The Journal of Biochemistry Vol. 108 page： 483-487 1990
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Transfer of phosphoryl group between two regulatory proteins involved in osmoregulatory expression of the ompF and ompC genes in Escherichia coli Reviewed
Aiba, H., Mizuno, T., and Mizushima, S.
J. Biol. Chem. Vol. 264 ( 15 ) page： 8563-8567 1989
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Regulation of gene expression in prokaryote : Signal transduction and phosphorylation
Vol. 61 page： 596-601 1989
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Signal transduction and osmoregulation in Escherichia coli : A single amino acid change in the protein kinase, EnvZ, results in loss of its phosphorylation and dephosphorylation abilities with respect to the activator protein, OmpR. Reviewed
Kanamaru, K., Aiba, H., Mizushima, S., and Mizuno, T.
J. Biol. Chem. Vol. 264 ( 36 ) page： 21633-21637 1989
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Evidence for the physiological importance of the phosphotransfer between the two regulatory components, EnvZ and OmpR, in osmoregulation in Escherichia coli Reviewed
Aiba, H., Nakasai, F., Mizushima, S., and Mizuno, T.
J. Biol. Chem. Vol. 264 ( 24 ) page： 14090-14094 1989
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Discovery of protein phosphorylation in bacterial signal transduction.
Experimental Medicine Vol. 7 ( 14 ) page： 1650-1653 1989
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Location of phosphorylation site and DNA-binding site of a positive regulator, OmpR, involved in activation of the osmoregulatory genes of Escherichia coli Reviewed
Kato, M., Aiba, H., Tate, S., Nishimura, Y., and Mizuno, T.
FEBS letters Vol. 249 ( 2 ) page： 168-172 1989
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Phosphorylation of a bacterial activator protein, OmpR, by a protein kinase, EnvZ, results in stimulation of its DNA-binding ability. Reviewed
Aiba, H., Nakasai, F., Mizushima, S., and Mizuno, T.
J. Biochem. ( 106 ) page： 5-7 1989
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Molecular analysis by deletion and site-directed mutagenesis of the cis-acting upstream sequence involved in activation of the ompF promoter in Escherichia coli Reviewed
Kato, M., Aiba, H., and Mizuno, T.
The Journal of Biochemistry Vol. 105 page： 341-347 1989
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グラム陰性菌の外膜蛋白質の生合成と特性
先端科学技術開発年鑑 page： 258-260 1988
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Function of micF as an antisense RNA in osmoregulatory expression of the ompF gene in Escherichia coli. Reviewed
Aiba, H., Matsuyama, S., Mizuno, T., and Mizushima, S.
J. Bacteriol. Vol. 169 ( 7 ) page： 3007-3012 1987
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A controllable expression-secretion vector constructed from the multiple trp promoter-operator, the signal peptide region of the ompF gene and the trpR gene in Escherichia coli
Itoh, M., Aiba, H., Inokuchi, K., Mizuno, T., Nagahari, K., Munakata, K., and Mizushima, S.
Agricultural and Biological Chemistry Vol. 50 ( 5 ) page： 1295-1302 1986