論文 - 西川 俊夫
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A practical, biomimetic, one-pot synthesis of firefly luciferin. 査読有り
Kato M, Tsuchihashi K, Kanie S, Oba Y, Nishikawa T
Scientific reports 14 巻 ( 1 ) 頁： 30461 2024年12月
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Collective Synthesis of Aplysiatoxin/Oscillatoxin Analogues by a Bioinspired Strategy. 査読有り
Hada K, Araki Y, Nokura Y, Urabe D, Nishikawa T
2022年11月
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An almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an odorant for the grass puffer. 査読有り
Noguchi Y, Suzuki T, Matsutani K, Sakakibara R, Nakahigashi R, Adachi M, Nishikawa T, Abe H
Scientific reports 12 巻 ( 1 ) 頁： 15087 2022年9月
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The characteristic response of domestic cats to plant iridoids allows them to gain chemical defense against mosquitoes. 査読有り 国際共著
Uenoyama R, Miyazaki T, Hurst JL, Beynon RJ, Adachi M, Murooka T, Onoda I, Miyazawa Y, Katayama R, Yamashita T, Kaneko S, Nishikawa T, Miyazaki M
Science advances 7 巻 ( 4 ) 2021年1月
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Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium 査読有り 国際共著
Qi Jianhua, Cheng Lihong, Sun Yujuan, Hirata Yushi, Ushida Naoki, Ma Zhonghua, Osada Hiroyuki, Nishikawa Toshio, Xiang Lan
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57 巻 ( 27 ) 頁： 8100-8104 2018年7月
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Biomimetic Synthesis and Structural Revision of Chaxine B and Its Analogues 査読有り
Hirata Yushi, Nakazaki Atsuo, Kawagishi Hirokazu, Nishikawa Toshio
ORGANIC LETTERS 19 巻 ( 3 ) 頁： 560-563 2017年2月
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Total Synthesis of Chiriquitoxin, an Analogue of Tetrodotoxin Isolated from the Skin of a Dart Frog 査読有り
Adachi, M.; Imazu, T.; Sakakibara, R.; Satake, Y.; Isobe, M.; Nishikawa, T.
Chem. Eur. J. 20 巻 頁： 1247-1251 2014年
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A Synthetic Route of the Saxitoxin Skeleton: Synthesis of Decarbamoyl-α-saxitoxinol, an Analog of Saxitoxin Produced by the Cyanobacterium Lyngbya wollei 査読有り
Angew. Chem. Int. Ed 50 巻 頁： 7176-7178 2011年
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*Synthetic Studies and biosynthetic speculation on marine alkaloid chartelline 査読有り
S. Kajii, T. Nishikawa, M. Isobe
Chem. Commun. 頁： 3121-3123 2008年
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*An Efficient Total Synthesis of Optically Active Tetrodotoxin from Levoglucosenone 査読有り
51. Urabe, D.; Nishikawa, T.; Isobe, M.
Chemistry, An Asian Journal 1 巻 頁： 125-135 2006年
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The First Asymmetric Total Synthesis of Tetrodotoxin 査読有り
Ohyabu, N.; Nishikawa, T.; Isobe, M.
Journal of American Chemical Society 125 巻 頁： 8798-8805 2003年
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Asymmetric Total Synthesis of 11-Deoxytetrodotoxin
"Nishikawa, T.; Asai, M.; Isobe, M."
Journal of the American Chemical Society 124 巻 頁： 7847-7852 2002年5月
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Stereocotrolled Synthesis of (-)-5.11-dideoxytetrodotoxin. 査読有り
Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Isobe, M.
Angewandte Chemie International Edition 38 巻 頁： 3081-3084 1999年
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Isolation of Paraphaeoketones: A Plausible Biosynthetic Explanation for Paraphaeolactones via a Benzilic Acid Rearrangement Rather than a Favorskii Rearrangement. 査読有り
Oinuma Y, Kanehara R, Maeda H, Nishikawa T, Konno K, Tanaka K, Hashimoto M
Journal of natural products 87 巻 ( 4 ) 頁： 1159 - 1170 2024年4月
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The odor of a nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, is detected by specific olfactory sensory neurons of the green spotted puffers. 査読有り
Suzuki T, Nakahigashi R, Adachi M, Nishikawa T, Abe H
Chemical senses 49 巻 2024年1月
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5, 6, 11-trideoxy tetrodotoxin attracts tiger puffer Takifugu rubripes. 査読有り
Miyazaki K, Suo R, Itoi S, Hirota J, Adachi M, Miyasaka T, Nishikawa T, Yokoyama T, Sato S, Takada K
Toxicon : official journal of the International Society on Toxinology 237 巻 頁： 107539 2024年1月
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Distribution of tetrodotoxin and its analogs in the toxic flatworm Planocera multitentaculata from Honshu Island, Japan 査読有り
Suo, R.; Tanaka, M.; Asano, M.; Nakahigashi, R.; Adachi, M.; Nishikawa, T.; Ogiso, S.; Matsubara, H.; Suzuki, N.; Itoi, S.
Fisheries Science 20 巻 2024年
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Total Synthesis of 19-Nordigitoxigenin, An Antiaroside Y Aglycon. 査読有り
Matsumura T, Nishikawa T, Nakazaki A
The Journal of organic chemistry 88 巻 ( 21 ) 頁： 15142 - 15150 2023年11月
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Assessing the safety and suitability of using silver vine as an olfactory enrichment for cats. 査読有り 国際共著
Uenoyama R, Ooka S, Miyazaki T, Mizumoto H, Nishikawa T, Hurst JL, Miyazaki M
iScience 26 巻 ( 10 ) 頁： 107848 2023年10月
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Geographical differences in the composition of tetrodotoxin and 5,6,11-trideoxytetrodotoxin in Japanese pufferfishes and their origins. 査読有り
Ito M, Shirai K, Oyama H, Yasukawa S, Asano M, Kihara M, Suo R, Sugita H, Nakahigashi R, Adachi M, Nishikawa T, Itoi S
Chemosphere 336 巻 頁： 139214 2023年9月
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The Asymmetric Total Synthesis and Configuration Confirmation of Aplysiaenal and Nhatrangin A, Truncated Derivatives of Aplysiatoxin and Oscillatoxin. 査読有り
Morishita M, Hada K, Kita M, Nishikawa T
Journal of natural products 86 巻 ( 4 ) 頁： 1033 - 1041 2023年4月
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Levels of Tetrodotoxins in Spawning Pufferfish, Takifugu alboplumbeus. 査読有り
Asano M, Ishizaki C, Tomonou T, Kihara M, Ito M, Yasukawa S, Shirai K, Oyama H, Izawa S, Kawamura R, Saito K, Suo R, Nakahigashi R, Adachi M, Nishikawa T, Sugita H, Itoi S
Marine drugs 21 巻 ( 4 ) 2023年3月
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An Asymmetric Total Synthesis of Picrotoxinin through a Mizoroki–Heck Reaction 査読有り
Matsumura, T.; Nishikawa, T.; Nakazaki, A.
34 巻 2023年
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A Convergent Synthesis of Tetracyclic Indole Compounds by a Palladium-Catalyzed Cross-Coupling and Tandem Cyclization Reaction 査読有り
Ono, Y.; Higuchi, K.; Yamaguchi, M.; Sugino, K.; Nakazaki, A.; Adachi, M.; Nishikawa, T.
Synlett 34 巻 頁： 364 - 368 2023年
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7-Epi-30-Methyloscillatoxin D from an Okinawan Cyanobacterium Okeania hirsuta 査読有り 国際共著
Kanda, N.; Zhang, B-T.; Shinjo, A.; Kamiyama, M.; Nagai, H.; Uchida, H.; Araki, Y.; Nishikawa, T.; Satake, M.
Natural Product Communications 18 巻 頁： 1 - 5 2023年
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Changes in Tissue Distribution of Tetrodotoxin and Its Analogues in Association with Maturation in the Toxic Flatworm, Planocera multitentaculata. 査読有り 国際共著
Oyama H, Ito M, Suo R, Goto-Inoue N, Morisasa M, Mori T, Sugita H, Mori T, Nakahigashi R, Adachi M, Nishikawa T, Itoi S
Marine biotechnology (New York, N.Y.) 2022年11月
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Tetrodotoxins in the flatworm Planocera multitentaculata.
Suo R, Tanaka M, Oyama H, Kojima Y, Yui K, Sakakibara R, Nakahigashi R, Adachi M, Nishikawa T, Sugita H, Itoi S
Toxicon : official journal of the International Society on Toxinology 216 巻 頁： 169 - 173 2022年9月
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Structural verification of petromyzestrosterol by total syntheses of both C14-epimers of its 3-<i>O</i>-methyl derivative. 査読有り
Nakazaki A, Kawai M, Nishikawa T
Organic & biomolecular chemistry 20 巻 ( 32 ) 頁： 6432 - 6435 2022年8月
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Total Syntheses of the Proposed Biosynthetic Intermediates of Tetrodotoxin Tb-210B, Tb-226, Tb-242C, and Tb-258. 査読有り
87 巻 ( 14 ) 頁： 9023 - 9033 2022年7月
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Domestic cat damage to plant leaves containing iridoids enhances chemical repellency to pests. 査読有り 国際共著
Uenoyama R, Miyazaki T, Adachi M, Nishikawa T, Hurst JL, Miyazaki M
iScience 25 巻 ( 7 ) 頁： 104455 2022年7月
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Local Differences in the Toxin Amount and Composition of Tetrodotoxin and Related Compounds in Pufferfish (<i>Chelonodon patoca</i>) and Toxic Goby (<i>Yongeichthys criniger</i>) Juveniles. 査読有り 国際共著
Ito M, Furukawa R, Yasukawa S, Sato M, Oyama H, Okabe T, Suo R, Sugita H, Takatani T, Arakawa O, Adachi M, Nishikawa T, Itoi S
Toxins 14 巻 ( 2 ) 2022年2月
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Green spotted puffers detect a nontoxic TTX analog odor using crypt olfactory sensory neurons. 査読有り
Suzuki T, Nakahigashi R, Adachi M, Nishikawa T, Abe H
Chemical senses 47 巻 2022年1月
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The Synthesis of simplified analogues of crambescin B carboxylic acid and their inhibitory activity of voltage-gated sodium channels: new aspects of atructure-activity relationships. 査読有り
Nakazaki, A.; Mouri, S.; Nakane, Y.; Ishikawa, Y.; Yamashira,M.; Nishikawa, T.
Heterocycles 2022年
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Synthesis of the 8-Deoxy Analogue of 4,9-Anhydro-10-hemiketal-5-deoxy-tetrodotoxin, a Proposed Biosynthetic Precursor of Tetrodotoxin. 査読有り
Miyasaka T, Adachi M, Nishikawa T
Organic letters 23 巻 ( 23 ) 頁： 9232 - 9236 2021年12月
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Total synthesis and biological evaluation of oscillatoxins D, E, and F. 査読有り
Araki Y, Hanaki Y, Kita M, Hayakawa K, Irie K, Nokura Y, Nakazaki A, Nishikawa T
Bioscience, biotechnology, and biochemistry 85 巻 ( 6 ) 頁： 1371 - 1382 2021年5月
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Total Synthesis of the Cardiotonic Steroid (+)-Cannogenol. 査読有り
Watanabe S, Nishikawa T, Nakazaki A
The Journal of organic chemistry 86 巻 ( 4 ) 頁： 3605 - 3614 2021年2月
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Biomimetic Synthesis of the CDE Ring Moiety of Physalins, Complex 13,14-Secosteroids. 査読有り
Araki Y, Nakazaki A, Nishikawa T
Organic letters 23 巻 ( 3 ) 頁： 989 - 994 2021年2月
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First Detection of Tetrodotoxins in the Cotylean Flatworm <i>Prosthiostomum trilineatum</i>. 査読有り
Suo R, Kashitani M, Oyama H, Adachi M, Nakahigashi R, Sakakibara R, Nishikawa T, Sugita H, Itoi S
Marine drugs 19 巻 ( 1 ) 2021年1月
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Synthesis of the 8-Deoxy Analogue of 4,9-Anhydro-10-hemiketal-5-deoxy-tetrodotoxin, a Proposed Biosynthetic Precursor of Tetrodotoxin. 査読有り
(1) Miyasaka, T.; Adachi, M.; Nishikawa, T.
Org. Lett. 23 巻 頁： 9232 - 9236 2021年
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Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions. 査読有り
Hanaki, Y., Araki, Y., Nishikawa, T., Yanagita, R. C.
Fundam. Toxicol. Sci. 8 巻 ( 3 ) 頁： 69 - 73 2021年
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Total Synthesis and biological evaluation of oscillatoxins D, E, and F. 査読有り
Araki, Y.; Hanaki, Y.; Kita, M.; Hayakawa, K.; Irie, K.; Nokura, Y.; Nakazaki, A.; Nishikawa, T.
Biosci. Biotechnol. Biochem. 85 巻 ( 6 ) 頁： 1371 - 1382 2021年
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Oscillatoxin E and Its C7 Epimer Show Distinct Growth Inhibition Profiles against Several Cancer Cell Lines. 査読有り
Hanaki, Y., Araki, Y., Nishikawa, T., Yanagita, R. C.
Heterocycles 102 巻 ( 12 ) 頁： 2353 - 2362 2021年
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Biosynthesis of Indole Diterpene Lolitrems: Radical-Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton. 査読有り
Jiang Y, Ozaki T, Harada M, Miyasaka T, Sato H, Miyamoto K, Kanazawa J, Liu C, Maruyama JI, Adachi M, Nakazaki A, Nishikawa T, Uchiyama M, Minami A, Oikawa H
Angewandte Chemie (International ed. in English) 59 巻 ( 41 ) 頁： 17996 - 18002 2020年10月
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Studies toward the Synthesis of Chartelline C. 査読有り
Nakane Y, Nakazaki A, Nishikawa T
The Journal of organic chemistry 85 巻 ( 11 ) 頁： 7534 - 7542 2020年6月
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New Synthetic Method for Efficient Synthesis of Bioactive Natural Products -Biomimetic Synthesis of Chaxines- 査読有り
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN 78 巻 ( 6 ) 頁： 566 - 574 2020年6月
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Biomimetic Synthesis of Chaxine and its Related Compounds. 査読有り
Niki M, Hirata Y, Nakazaki A, Wu J, Kawagishi H, Nishikawa T
The Journal of organic chemistry 85 巻 ( 7 ) 頁： 4848 - 4860 2020年4月
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Synthesis of Oxy-Functionalized Steroidal Skeletons via Mizoroki-Heck and Intramolecular Diels-Alder Reactions. 査読有り
Watanabe S, Nishikawa T, Nakazaki A
Organic letters 21 巻 ( 18 ) 頁： 7410 - 7414 2019年9月
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Asymmetric Synthesis of the Aromatic Fragment of Sespendole. 査読有り
Ono Y, Nakazaki A, Ueki K, Higuchi K, Sriphana U, Adachi M, Nishikawa T
The Journal of organic chemistry 84 巻 ( 15 ) 頁： 9750 - 9757 2019年8月
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Concise Stereocontrolled Synthesis of an alpha-Carbagalactose Segment of RCAI-56, a Candidate Anticancer Agent 査読有り
Ushida Naoki, Nagai Nobukazu, Adachi Masaatsu, Nishikawa Toshio
SYNLETT 30 巻 ( 8 ) 頁： 977-981 2019年5月
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Total Syntheses and Determination of Absolute Configurations of Cep-212 and Cep-210, Predicted Biosynthetic Intermediates of Tetrodotoxin Isolated from Toxic Newt. 査読有り
Adachi M, Miyasaka T, Kudo Y, Sugimoto K, Yotsu-Yamashita M, Nishikawa T
Organic letters 21 巻 ( 3 ) 頁： 780 - 784 2019年2月
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A concise synthesis of peramine, a metabolite of endophytic fungi
Ito Shinsaku, Yamamoto Yuta, Nishikawa Toshio
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 82 巻 ( 12 ) 頁： 2053 - 2058 2018年12月
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Toward a Synthesis of Fawcettimine-Type Lycopodium Alkaloids: Stereocontrolled Synthesis of a Functionalized Azaspirocycle Precursor.
Huang WY, Nishikawa T, Nakazaki A
The Journal of organic chemistry 83 巻 ( 18 ) 頁： 11108 - 11117 2018年9月
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Semi-synthesis and Structure-Activity Relationship of Neuritogenic Oleanene Derivatives
Bian Linglin, Cao Shining, Cheng Lihong, Nakazaki Atsuo, Nishikawa Toshio, Qi Jianhua
CHEMMEDCHEM 13 巻 ( 18 ) 頁： 1972-1977 2018年9月
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SYNTHESIS OF DIBROMO COMPOUNDS CONTAINING 2,6-DIOXABICYCLO[3.1.1]HEPTANE SIMILAR TO CORE MOIETY OF THROMBOXANE A(2)
Nokura Yoshihiko, Nakazaki Atsuo, Nishikawa Toshio
HETEROCYCLES 96 巻 ( 1 ) 頁： 127-136 2018年1月
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Spiro Bicyclic Guanidino Compounds from Pufferfish: Possible Biosynthetic Intermediates of Tetrodotoxin in Marine Environments.
113. Ueyama, N.; Sugimoto, K.; Kudo, Y.; Onodera, K.; Cho, Y.; Konoki, K.; Nishikawa, T.; Yotsu-Yamashita, M.
Chem. Eur. J. 24 巻 頁： 7250 – 7258 2018年
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Synthetic Route to Oscillatoxin D and Its Analogues.
Nokura Y, Araki Y, Nakazaki A, Nishikawa T
Organic letters 19 巻 ( 21 ) 頁： 5992 - 5995 2017年11月
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Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Na(v)1.1 to Na(v)1.7)
Tsukamoto Tadaaki, Chiba Yukie, Wakamori Minoru, Yamada Tomoshi, Tsunogae Shunsuke, Cho Yuko, Sakakibara Ryo, Imazu Takuya, Tokoro Shouta, Satake Yoshiki, Adachi Masaatsu, Nishikawa Toshio, Yotsu-Yamashita Mari, Konoki Keiichi
BRITISH JOURNAL OF PHARMACOLOGY 174 巻 ( 21 ) 頁： 3881-3892 2017年11月
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Concise Synthesis of a Cyclopentane Intermediate Possessing All Nitrogen Functionalities for Pactamycin
Matsumoto Nobuyuki, Nakazaki Atsuo, Nishikawa Toshio
SYNLETT 28 巻 ( 17 ) 頁： 2303-2306 2017年10月
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De Novo Synthesis of Possible Candidates for the Inagami-Tamura Endogenous Digitalis-like Factor.
Nakazaki A, Hashimoto K, Ikeda A, Shibata T, Nishikawa T
The Journal of organic chemistry 82 巻 ( 17 ) 頁： 9097 - 9111 2017年9月
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New regiocontrolled syntheses of pyrrolopyrazinones and its application to the synthesis of peramine
Yamamoto Yuta, Nakazaki Atsuo, Nishikawa Toshio
TETRAHEDRON 73 巻 ( 25 ) 頁： 3443-3451 2017年6月
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Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B
Tsukamoto Tadaaki, Chiba Yukie, Nakazaki Atsuo, Ishikawa Yuki, Nakane Yoshiki, Cho Yuko, Yotsu-Yamashita Mad, Nishikawa Toshio, Wakamori Minoru, Konoki Keiichi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27 巻 ( 5 ) 頁： 1247-1251 2017年3月
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Palladium-Catalyzed Cascade Wacker/Allylation Sequence with Allylic Alcohols Leading to Allylated Dihydropyrones. 査読有り
Huang, W.-Y.; Nishikawa, T.; Nakazaki, A.
ACS Omega ( 2 ) 頁： 487-495 2017年2月
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One-Step Transformation of Trichloroacetamide into Isonitrile
Adachi Masaatsu, Miyasaka Tadachika, Hashimoto Honoka, Nishikawa Toshio
ORGANIC LETTERS 19 巻 ( 2 ) 頁： 380-383 2017年1月
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Concise Synthesis of a Cyclopentane Intermediate Possessing All nitrogen Functionalities for Pactamycin. 査読有り
Matsumoto, N.; Nakazaki, A.; Nishikawa, T.
Synlett 28 巻 ( 17 ) 頁： 2303-2306 2017年
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New regiocontrolled syntheses of pyrrolopyrazinones and its application to the synthesis of peramine. 査読有り
Yamamoto, Y.; Nakazaki, A.; Nishikawa, T.
Tetrahedron ( 73 ) 頁： 3443-3451 2017年
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Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B. 査読有り
Tsukamoto, T.; Chiba, Y.; Nakazaki, A.; Ishikawa, Y.; Nakane, Y.; Cho, Y.; Nishikawa, T.; Yotsu-Yamashita, M.; Wakamori, M.; Konoki K.
Med. Chem. Lett ( 27 ) 頁： 1247-1251 2017年
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Biomimetic Synthesis and Structural Revision of Chaxine B and Its Analogues. 査読有り
Hirata, Y.; Nakazaki, A.; Kawagishi, H.; Nishikawa, T.
Org. Lett. ( 19 ) 頁： 560-563 2017年
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A Synthetic Strategy for Saxitoxin Skeleton by a Cascade Bromocyclization: Total Synthesis of (+)-Decarbamoyl-α-saxitoxinol. 査読有り
Ueno, S.; Nakazaki, A.; Nishikawa, T.
Org. Lett. ( 18 ) 頁： 6368-6371 2016年
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A Divergent Approach to the Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from Atropisomeric N-Aryl Oxindole Derivatives. 査読有り
Nakazaki, A.; Mori, A.; Kobayashi, S.; Nishikawa, T
Chem. Asian J. ( 11 ) 頁： 3267-3274 2016年
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One-pot non-enzymatic formation of firefly luciferin in a neutral buffer fromp-benzoquinone and cysteine. 査読有り
Kanie S.; Nishikawa T.; Ojika M.; Oba Y.
Scientific Reports 24794 巻 ( 6 ) 2016年
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Asymmetric synthesis of crambescin A-C carboxylic acids and their inhibitory activity on voltage-gated sodium channels. 査読有り
Nakazaki A.; Nakane Y.; Ishikawa Y.; Yotsu-Yamashita M.; Nishikawa T.
Org. Biomol. Chem. ( 14 ) 頁： 5304-5309 2016年
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Improved Syntheses of (+)-Iridomyrmecin and (-)-Isoiridomyrmecin, Major Components of Matatabilactone. 査読有り
Adachi M.; Miyazawa Y.; Nishikawa, T.
Natural Product Communications 2016 ( 11 ) 頁： 883-886 2016年
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Multifunctionality of the N-Trichloroacetyl Group Developed in the Synthesis of Tetrodotoxin, a Puffer Fish Toxin 査読有り
(1) Toshio Nishikawa, Daisuke Urabe, Masaatsu Adachi, Minoru Isobe
Synlett 26 巻 頁： 1930-1939 2015年5月
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Synthesis of a C-N Axially Chiral N-Aryl Isatin through Asymmetric Intramolecular N-Arylation 査読有り
Nakazaki, A.; Miyagawa, K.; Nishikawa, T.
Eur. J. Org. Chem. 頁： 4603–4606 2015年
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Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from N-Aryl-3-Chlorooxindoles 査読有り
Nakazaki, A.; Miyagawa, K.; Nishikawa, T.
Synlett ( 26 ) 頁： 1116-1120 2015年
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Stereocontrolled Synthesis of ABC-tricycle of Solanoeclepin A. 査読有り
Adachi, M.; Torii, M.; Nishikawa, T.
Synlett ( 26 ) 頁： 965-969 2015年
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Unexpected Metal-Free Transformation of gem-Dibromomethylenes to Ketones under Acetylation Conditions. 査読有り
Kimura, R.; Sawayama, Y.; Nakazaki, A.; Miyamoto, K.; Uchiyama, M.; Nishikawa, T.
Chem. Asian J. ( 10 ) 頁： 1035-1041 2015年
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Synthesis of 1.5-dioxaspiro[3.4]octane through bromocation-induced cascade cyclization 査読有り
Nakazaki, A.; Nakane, Y.; Ishikawa, Y.; Nishikawa, T.
Heterocycles 91 巻 頁： 1157- 2015年
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Synthesis of crambescin B carboxylic acid,a potent inhibitor of voltage-gated sodium channels 査読有り
Atsuo Nakazaki, Yuki Ishikawa, Yusuke Sawayama, Mari Yotsu-Yamashita Toshio Nishikawa
Org. Biomol. Chem. ( 12 ) 頁： 53–56 2014年
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Synthesis of 5- and 8-Deoxytetrodotoxin 査読有り
Satake, Y.: Adachi, M.; Tokoro, S.; Yotsu-Yamashita, M.; Isobe M.; Nishikawa, T.
Chem. Asian J. 9 巻 頁： 1922-1932 2014年
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Synthesis of 5,6,11-Trideoxytetrodotoxin 査読有り
Adachi M.: Sakakibara, R.; Satake, Y.; Isobe, M.; Nishikawa, T.
Chem. Lett. 43 巻 頁： 1719-1721 2014年
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A New Deprotection of MTM Ether. 査読有り
Adachi M.; Hashimoto, H.; Sakakibara, R.; Imazu, T.; Nishikawa, T.
Synlett 頁： 2498-2502 2014年
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An improved synthesis of (-)-5,11-Dideoxytetrodotoxin 査読有り
Adachi, M.; Imazu, T.; Isobe, M.; Nishiakwa. T.
J. Org. Chem. 78 巻 頁： 1699-1705 2013年
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First Identification of 5,11-Dideoxytetrodotoxin in Marine Animals, and Characterization of Major Fragment Ions of Tetrodotoxin and Its Analogs by High Resolution ESI-MS/MS 査読有り
Mari Yotsu-Yamashita, Yuka Abe, Yuta Kudo, Raphael Ritson-Williams, Valerie J. Paul,Keiichi Konoki, Yuko Cho, Masaatsu Adachi, Takuya Imazu, Toshio Nishikawa, Minoru Isobe.
Mar. Drugs ( 11 ) 頁： 2799-2813 2013年
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Stereocontrolled Total synthesis of Polygalolide A. 査読有り
Yamada, H. Adachi, M.; Isobe, M.; Nishikawa, T.
Chem. Asian J. ( 8 ) 頁： 1428-1435 2013年
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Structure Study on a naturally Occurring Terphenyl Quinone 査読有り
Nakazaki, A.; Huang, W-Y.; Koga K.; Yingyongnarongkul B-E.; Boonsombat J.; Sawayama Y.; Tsujimoto T.; Nishikawa, T.
Biosci. Biotechnol. Biochem. ( 77 ) 頁： 1529-1532 2013年
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Synthesis of Tetracyclic Indoline and Indolenine Derivatives Having β-Lactam Using Amphiphilic Reactivity of 2-Methylindolenine 査読有り
Nakazaki, A.; Hara, Y.; Kajii, S.; Nishikawa, T
Heterocycles 87 巻 頁： 611-625 2013年
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Stereocontrolled Synthesis of an Indole Moiety of Sespendole and Stereochemical Assignment of the Side Chain 査読有り
Adachi, M.; Higuchi, K.; Thasana, N.; Yamada, H.; Nishikawa, T.
Org. Lett. 14 巻 頁： 144-117 2012年
-
Synthetic studies on pactamycin, a potent antitumor antibiotic 査読有り
51. Matsumoto, N.; Tsujimoto, T.; Nakazaki, A.; Isobe M.; Nishikawa, T.
RSC, Advances 2 巻 頁： 9448-9462 2012年
-
Bromocyclization of Alkynyl Guanidine: A New Approach to the Synthesis of Cyclic Guanidines of Saxitoxin 査読有り
頁： 651-654 2011年2月
-
Synthetic Study on Sespendole, an Indole Sesquiterpene Alkaloid: Stereocontrolled Synthesis of the Sesquiterpene Segment Bearing All Requisite Stereogenic Centers. 査読有り
Sugino, K.; Nakazaki, A.; Isobe, M.; Nishikawa, T.
頁： 647-650 2011年2月
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Dynamic Chirality Determines Critical Roles for Bioluminescence in Symplectin–Dehydrocoelenterazine System 査読有り
68. V. Kongjinda, Y. Nakashima, N.Tani, M. Kuse, T. Nishikawa, Chin-Hui Yu, N. Harada, M. Isobe
6 巻 頁： 2080-2091 2011年
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Concise Synthesis of Deformylflustrabromine, a Marine Indole Alkaloid Through Propargyl Dicobalt Hexacarbonyl Complex 査読有り
Isaji, H.; Nakazaki, A.; Isobe, M.; Nishikawa, T.
40 巻 頁： 1079-1081 2011年
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A New Ring Expansion for a Chiral Hexahydroazulene Skeleton Possessing an Angular Methyl Group 査読有り
70. Adachi, M.; Komada, T.; Nishikawa, T.
J. Org. Chem. 76 巻 頁： 6942-6945 2011年
-
Total Synthesis of Polygalolide A 査読有り
Adachi, M.; Yamada, H.; Isobe,M.; Nish1ikawa, T.
Org. Lett. 24 巻 頁： 6532-6535 2011年
-
Identification of a Fluorescent Compound in the Cuticle of the Train Millipede Parafontaria laminata armigera. 査読有り
Kuse, M.; Yanagi, M.; Tanaka, E.; Tani, N.; Nishikawa, T.
Biosci. Biotechnol. Biochem. 74 巻 頁： 2307-2309 2010年10月
-
Synthesis of an Advanced Intermediate Bearing Two Hydroxy Groups for (-)-Tetrodotoxin and Its Analogs 査読有り
Nishikawa, T.; Koide, Y.; Adachi, M.; Isobe, M.
Bull. Chem. Soc. Jpn. 86 巻 頁： 66-68 2010年
-
Scalable Synthesis of a New Dihydroxylated Intermediate for tetrodotoxin and Its Analogues 査読有り
atake, Y.; Nishikawa, T.; Hiramatsu, T.; Araki, H.; Isobe, M.
Synthesis 頁： 1992-1998 2010年
-
Syntheses of N-Acylosoxazolidine derivatives, related to a partial strycture found in zetekitoxin AB, a Golden Frog Poison 査読有り
Nishikawa, T.; Urabe, D.; Isobe, M.
Heterocycles 79 巻 頁： 379-385 2009年
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Dehydrocoelenterazine Is the Organic Substance Constituting the Prosthetic Group of Pholasin 査読有り
Tanaka, E.; Kuse, M.; Nishikawa, T.
ChemBioChem, 10 巻 頁： 2725-2729 2009年
-
Selective Oxidation by the Hydroperoxide in the Photoprotein, Aequorin 査読有り
12. Doi, I.; Kuse, M.; Nishikawa, T.; Isobe, M.
Bioorg. Med. Chem. 17 巻 頁： 3399-3404 2009年
-
Synthesis of Four Lysine-Linked Cereulide Analogs showing K+ Ionophoric Activity as Lead Compounds for Emetic Toxin-Detection by Immunoassays. 査読有り
Makarasen, A.; Nishikawa, T.; Isobe, M.
Synthesis 頁： 2184-2204 2009年
-
Imino-O-Tosylate in Suzuki-Miyaura Reaction for substitution of the Pyrazine Rings: A Study for the Synthesis of Coelenterazine Analogs. 査読有り
Makarasen, A.; Kuse, M.; Nishikawa, T.; Isobe, M.
Bull. Chem. Soc. Jpn. 82 巻 頁： 870-878 2009年
-
Pholasin luminescence is enhanced by addition of dehydrocoelenterazine 査読有り
Kuse, M.; Tanaka, E.; Nishikawa, T.
Bioorganic & Medicinal Chemistry Letters 18 巻 頁： 5657-5659 2008年6月
-
Regioselectivity of Larock Indole Synthesis by Using Functionalized Alkynes 査読有り
Sugino, K.; Yoshimura, H.; Nishikawa, T.; Isobe, M.
Bioscience, Biotechnology & Biochemistry 72 巻 頁： 594-597 2008年4月
-
Synthesis of N-hydroxyenamide, a potential precursor of chertelline
S. Kajii, T. Nishikawa, M. Isobe
Tetrahedron Letters 49 巻 頁： 594-597 2008年
-
Synthesis of beta-Analogues of C-Mannosyltryptophan, a Novel C-Glycosylamino Acid Found in Proteins 査読有り
50. Nishikawa, T.; Koide, Y.; Kanakubo, A.; Yoshimura, H.; Isobe, M.
Organic Biochemical Chemistry 4 巻 頁： 1268-1277 2006年
-
Syntheses of Naturally Occurring Terphenyls and Its Related Compounds, 査読有り
Sawayama, Y.; Tsujimoto, T.; Sugino, K.; Nishikawa, T.; Isobe., M.; Kawagishi, H
Bioscience, Biotechnology & Biochemistry 70 巻 ( 12 ) 頁： 2998-3003 2006年
-
*One-Pot Transformation of Trichloroacetamide into Readily Deprotectable Carbamates 査読有り
Nishikawa, T.; Urabe, D.; Tomita, M.; Tsujimoto, T.; Iwabuchi, T.; Isobe, M.
Organic Letters 8 巻 頁： 3263-3265 2006年
-
*Stereocontrolled Synthesis of alfa-C-Mannosyltryptohan and its Analogues. 査読有り
Nishikawa, T.; Koide, Y.; Kajii, S.; Wada, K.; Ishikawa, M., Isobe, M.
Organic Biochemical Chemistry 3 巻 頁： 687-700 2005年
-
Synthesis of Functionalized Cyclopentane for Pactamycin, A potent Antitumor Antibiotic 査読有り
Tsujimoto, T.; Nishikawa, T.; Urabe, D.; Isobe, M.
Synlett 頁： 433-436 2005年
-
A Novel and Highly Stereoselective Carbon-chain Extension Reaction at the C-6 Position of 1,6-Anhydropyranose 査読有り
Nishikawa, T.; Mishima, M.; Ohyabu, N.; Isobe, M.
Tetrahedron Letters 45 巻 頁： 175-178 2004年
-
A novel deprotection of trichloroacetamide, 査読有り
Urabe, D.; Sugino K.; Nishikawa, T.; Isobe, M.
Tetrahedron Letters 45 巻 頁： 9405-9407 2004年
-
Novel Synthesis of Bromoindolenine with Spiro-b-lactam in Chartelline. 査読有り
Nishikawa, T.; Kajii, S.; Isobe, M.
Synlett 頁： 2025-2027 2004年
-
*An efficient total synthesis of optically active tetrodotoxin. 査読有り
Nishikawa, T.; Urabe, D.; Isobe,
Angewante. Chemie International Edition 43 巻 頁： 4782-4785 2004年
-
Synthesis of Model Compound Containing an Indole Spiro-b-lactam Moiety with Vinylchloride in Chartellines 査読有り
Nishikawa, T.; Kajii, S.; Isobe, M.
Chemistry Letters 33 巻 頁： 440-441 2004年
-
a-C-Mannnosyltryptophan is not recognized by conventional mannose-binding lectins 査読有り
Nishikawa, T.; Kajii, S.; Sato, C.; Yasukawa, Z.; Kitajima, K.; Isobe, M.
Bioorganic Medicinal Chemistry 12 巻 頁： 2343-2348 2004年
-
Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analog of Puffer Fish Toxin 査読有り
Nishikawa, T.; Urabe, D.; Yoshida, K.; Iwabuchi, T.; Asai, M.; Isobe, M
Chemistry, A European Journal 10 巻 頁： 452-462 2004年
-
Biological activity of 8,11-dideoxytetrodotoxin: Lethality to mice and the inhibitory activity to cytotoxicity of ouabain and veratridine in mouse neuroblastoma cells, Neuro-2a 査読有り
Yotsu-Yamashita, M.; Urabe, D.; Asai, M.; Nishikawa, T.; Isobe M.
Toxicon 42 巻 頁： 557-560 2003年
-
"Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analog of Puffer Fish Toxin"
Nishikawa, T.; Urabe, D.; Yoshida, K.; Iwabuchi, T.; Asai, M.; Isobe, M.
Organic Letters 4 巻 頁： 2679-2682 2002年7月
-
Scandium Perchlorate as a Superior Lewis Acid for Regioselective Ring Opening of Aziridine Carboxylate with Indoles
Nishikawa, T.; Kajii, S.; Wada, K.; Ishikawa, M.; Isobe, M.
Synthesis 1658－1662 巻 2002年1月
-
Synthesis of Novel α-C-Glycosylamino Acids and Reverse Regioselectivity in Larock's Heteroannulation for the Synthesis of the Indole Nucleus
Nishikawa, T.; Wada, K.; Isobe, M.
Bioscience, Biotechnology & Biochemistry" 66 巻 頁： 2273-2278 2002年1月
-
Total Synthesis of a-C-Mannosyltryptophan.
Nishikawa, T.; Ishikawa, M.; Wada, K.; Isobe, M.
Synlett 頁： 945-947 2001年7月
-
"Stereocontrolled Synthesis of (-)-5,11-Dideoxytetrodotoxin."
"M. Asai, T. Nishikawa, N. Ohyabu, N. Yamamoto, M. Isobe"
Tetrahedron 57 巻 頁： 4543-4558 2001年4月
-
Synthesis of Common Key Intermediate for (-)-Tetrodotoxin and its Analogs
"Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Fukuda, Y.; Isobe, M."
Tetrahdron 57 巻 頁： 3875-3883 2001年4月
-
Stereoselektive Synthese von (-)-5.11-didesoxytetrodotoxin.
"Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Isobe, M."
Angewandte Chemie 111 巻 頁： 3268-3271 1999年11月
-
Hydrosilylation of acetylenes with catalytic biscobalthexacarbonyl complex and its application to heteroconjugate addition methodology.
"Isobe, M.; Nishizawa, R.; Nishikawa, T.; Yoza, K."
Tetrahedron Letters 40 巻 頁： 6927-6930 1999年5月
-
Electronic Factors in the C-Glycosidation with Silylacetylene. 査読有り
"29. Isobe, M.; Saeeng, R.; Nishizawa, R.; Konobe, M.; Nishikawa, T."
Chemistry Letters 頁： 467-468 1999年3月
-
Palladium Catalyzed Substitution Reaction of Allylic Derivatives with Tinacetylene
"Nishikawa T.; Isobe, M."
"Bioscience, Biotechnology & Biochemistry" 63 巻 頁： 238-242 1999年1月
-
New Synthetic Route for Guanidine from Trichloroacetamide for Tetrodotoxin and its Related Compounds.
"Nishikawa, T.; Ohyabu, N.; Yamamoto, N. ; Isobe, M."
Tetrahedron 55 巻 頁： 4325-4340 1999年1月
-
Synthesis of α-C-Mannosyltryptophan Derivative, Naturally Occurring C-Glycosyl Amino Acid Found in Human Ribonuclease." 査読有り
"Nishikawa, T.; Ishikawa, M.; Isobe, M."
Synlett 頁： 123-125 1999年1月
-
Stereocontrolled Synthesis and Reactivity of Sugar Acetylene. 招待有り
"6. Isobe, M.; Nishizawa, R.; Hosokawa, S.; Nishikawa, T."
"Journal of Chemical Society, Chemical Communications" 頁： 2665-2676 1998年1月
-
Improved Coitions for Facile Overman Rearrangement.
"Nishikawa, T., Asai, M., Ohyabu, N. and Isobe, M.,"
Journal of Organic Chemistry 63 巻 頁： 188-192 1998年1月
-
Novel Stereoselective Reaction of Levoglucosenone with Furfural.
"Nishikawa, T., Araki, H. and Isobe, M.,"
"Bioscience, Biotechnology & Biochemistry" 62 (#1) 巻 頁： 190-192 1998年1月
-
Stereoelectronic a Steric Control in Chiral Cyclohexane Synthesis toward (-)-Tetrodotoxin.
"Bamba, M., Nishikawa, T. and Isobe, M.,"
Tetrahedron 54 巻 頁： 6639-6650 1998年1月
-
Stereoelectronic a Steric Effects for Critical Oxidation to the Cyclohexane Derivatives for an Intermediate to (-)-Tetrodotoxin. 査読有り
"Bamba, M., Nishikawa, T. and Isobe, M.,"
Synlett 頁： 371-372 1998年1月
-
Stereoelectronic and Steric Control in Chiral Cyclohexane Synthesistoward (-)-Tetrodotoxin(共著)
Bamba, M.; Nishikawa, T.; Isobe, M.
Tetrahedron 54 巻 ( 24 ) 頁： 6639-6650 1998年
-
Stereocontrolled Synthesis and Reactivity of Sugar Acetylene 査読有り
Isobe, M.; Nishizawa, R.; Hosokawa, S.; Nishikawa, T.
Journal of Chemical Society,Chemical Communications 頁： 2665-2676 1998年
-
Synthesis a Biological Evaluation of Novel Cyclic Enediyne Compous Related to Dynemicin A as Antitumor Agents. 査読有り
"Unno, R., Michishita, H., Inagaki, H., Baba, Y., Jomori, T., Nishikawa, T. and Isobe, M.,"
Chemical & Pharmaceutical Bulletin 45 巻 頁： 125-133 1997年1月
-
Structure-Activity Relationships of Cyclic Enediynes Related to Dynemicin A. Part 2: Synthesis a Antitumor Activity of 9- a 12-Substituted Enediynes. 査読有り
"Unno, R., Michishita, H., Inagaki, H., Suzuki, Y., Baba, Y., Jomori, T., Moku, M., Nishikawa, T. and Isobe, M.,"
Bioorganic & Medicinal Chemistry 5 巻 頁： 903-919 1997年1月
-
Structure-Activity Relationships of Cyclic Enediynes Related to Dynemicin A. Part 1: Synthesis a Antitumor Activity of 9-Acetoxy Enediyne Equipped with Aryl Carbamate Moieties. 査読有り
"Unno, R., Michishita, H., Inagaki, H., Suzuki, Y., Baba, Y., Jomori, T., Nishikawa, T. and Isobe, M.,"
Bioorganic & Medicinal Chemistry 5 巻 頁： 883-901 1997年1月
-
Synthesis a Antitumor Effects of Water-Soluble Enediyne Compous Related to Dynemicin A.
"Unno, R., Michishita, H., Inagaki, H., Suzuki, Y., Baba, Y., Jomori, T., Nishikawa, T. and Isobe, M,"
Bioorganic & Medicinal Chemistry 5 巻 頁： 987-999 1997年1月
-
"Enzyme inhibitors, synthesis and approach to mechanism." 招待有り 査読有り
"Isobe, M., Tsuboi, K., Hosokawa, S., Bamba, M., Kira, K., Shibuya, S., Ohtani, I.I., Nishikawa, T. and Ichikawa, Y."
Pure & Applied Chemistry 69 巻 頁： 401-406 1997年
-
"Tin-Assisted Cyclization for Chiral Cyclohexane Synthesis, An Alternative Route to (-)-Tetrodotoxin Skeleton."
"Bamba, M., Nishikawa, T. and Isobe, M.,"
Tetrahedron Letters 37 (#45) 巻 頁： 8199-8202 1996年1月
-
Synthesis of Anthraquinone Part of Dynemicin A via Diels-Alder Reaction.
"Nishikawa, T., Moku, M., Suzuki, Y. and Isobe, M.,"
Chemistry Letters (#2) 巻 頁： 113-114 1996年1月
-
Synthesis a Biological Evaluation of Both Enantiomers of Dynemicin A Model Compou.
"Nishikawa, T., Yoshikai, M., Obi, K., Kawai, T., Unno, R., Jomori, T. and Isobe, M.,"
Tetrahedron 51 巻 頁： 9339-9352 1995年1月
-
Synthesis of Bicyclic Hydroxy Lactone Intermediate toward (-)-Tetrodotoxin.
Yamamoto, N., Nishikawa, T. and Isobe, M.
Synlett 頁： 505-506 1995年
-
Synthesis and Biological Evaluation of Both Enantiomers of Dynemicin A Model Compound 査読有り
Tetrahedron 51 巻 頁： 9339 1995年
-
Synthetic Studies on Antibiotic Dynemicin A. Synthesis of Cyclic Enediyne Model Compound of Dynemicin A 査読有り
Nishikawa, T.; Ino, A.; Isobe, M.
Tetrahedron 50 巻 頁： 1449-1468 1994年
-
Cesium Fluoride Promoted Cyclization in the Synthesis of Enediyne Antibiotics 査読有り
Nishikawa, T.; Shibuya S.; Isobe, M.
Synlett 頁： 482-484 1994年
-
One Pot Synthesis of Haloacetylenes from Trimethylsilylacetylene 査読有り
Nishikawa, T.; Shibuya S.; Hosokawa, S.; Isobe, M.
Synlett 頁： 485-486 1994年
-
Synthesis of Both Enantiomers of Dynemicin A Model Compound. New Remote Asymmetric Induction in Acetylide Addition into Quinoline Nucleus as Key Step.
Nishikawa, T.; Yoshikai, M.; Obi, K.; Isobe, M.
Tetrahedron Letters 35 巻 頁： 7997-8000 1994年
-
Synthetic Studies on Dynemicin A. New Quinoline Synthesis for C, D and E rings.
Nishikawa, T.; Isobe, M.
Tetrahedron 50 巻 頁： 5621-5632 1994年
-
Methodologies for Synthesis of Heterocyclic Compounds. 招待有り 査読有り
Isobe, M.; Nishikawa, T.; Yamamoto, N.; Tsukiyama, T.; Ino, A.; Okita, T.
Journal of Heterocyclic Chemistry, 29 巻 頁： 619-625 1992年
-
Silyl and Tin Acetylene as Nucleophile toward Acyliminium Cation, a Plausible Key Reaction for Dynemicin, Enediyne Antitumor Antibiotic 査読有り
Nishikawa, T.; Isobe, M.; Goto, T.
Synlett 頁： 99-101 1991年
-
Synthetic Studies on the Bicyclo[7,3,1]-tridecendiyne System in an Antitumor Antibiotic, Dynemicin A 査読有り
Nishikawa, T.; Isobe, M.; Goto, T.
Synlett 頁： 393-394 1991年
-
Synthesis of a Simple Model Compound of Dynemicin and Cycloaromatization with Pinacol-Pinacolone Rearrangement in the strained Enediyne Medium Ring 査読有り
Nishikawa, T.; Ino, A.; Isobe; M.; Goto, T.
Chemistry Letters 頁： 1271-1274 1991年
-
Synthetic Studies on (-)-Tetrodotoxin(3)-Nitrogenation through Overman Rearrangement and Guanidine Ring Formation 査読有り
Tetrahedron Letters 31 巻 頁： 3327-3330 1990年
-
Methodology for Stereochemical Control in Bioactive Natural Product Synthesis --- New Methods toward Enediyne Antitumor Antibiotics. 招待有り 査読有り
Isobe, M.; Nishikawa, T.; Herunsalee, A.; Tsukiyama, T.; Hirose, Y.; Shimokawa, K.; Goto, T.
Pure & Applied Chemistry 62 巻 頁： 2007-2012 1990年
-
Asymmetric Synthesis via Heteroconjugate Addition-Valinol Template as Oxazolidine Heteroolefine vs Acetylenic Nucleophiles 査読有り
Isobe, M.; Hirose, Y.; Shimokawa, K.; Nishikawa, T.; Goto, T.
Tetrahedron Letters 31 巻 頁： 5499-5502 1990年
-
Synthesis of Chiral Cyclohexanes from Levoglucosenone and its Application to an Indole Alkaloid Reserpine 査読有り
Isobe, M.; Fukami, N.; Nishikawa, T.; Goto, T.
Heterocyles 25 巻 頁： 521-532 1987年
-
Synthetic Studies on a Stereochemically Complex Natural Product : Designs for the Total Synthesis of (-)-Tetrodotoxin 招待有り 査読有り
Isobe, M.; Nishikawa, T.; Fukami, N.; Goto, T.
Pure & Applied Chemistry 59 巻 頁： 399-406 1987年
-
Synthetic Studies on Tetrodotoxin [1] --- Stereocontrolled Synthesis of the Cyclohexane Moiety 査読有り
Isobe, M.; Nishikawa, T.; Pikul, S.; Goto, T.
Tetrahedron Letters 28 巻 頁： 6485-6488 1987年