Papers - NISHIKAWA, Toshio
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A practical, biomimetic, one-pot synthesis of firefly luciferin. Reviewed
Kato M, Tsuchihashi K, Kanie S, Oba Y, Nishikawa T
Scientific reports Vol. 14 ( 1 ) page： 30461 2024.12
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Collective Synthesis of Aplysiatoxin/Oscillatoxin Analogues by a Bioinspired Strategy. Reviewed
Hada K, Araki Y, Nokura Y, Urabe D, Nishikawa T
2022.11
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An almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an odorant for the grass puffer. Reviewed
Noguchi Y, Suzuki T, Matsutani K, Sakakibara R, Nakahigashi R, Adachi M, Nishikawa T, Abe H
Scientific reports Vol. 12 ( 1 ) page： 15087 2022.9
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The characteristic response of domestic cats to plant iridoids allows them to gain chemical defense against mosquitoes. Reviewed International coauthorship
Uenoyama R, Miyazaki T, Hurst JL, Beynon RJ, Adachi M, Murooka T, Onoda I, Miyazawa Y, Katayama R, Yamashita T, Kaneko S, Nishikawa T, Miyazaki M
Science advances Vol. 7 ( 4 ) 2021.1
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Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic Fusarium Reviewed International coauthorship
Qi Jianhua, Cheng Lihong, Sun Yujuan, Hirata Yushi, Ushida Naoki, Ma Zhonghua, Osada Hiroyuki, Nishikawa Toshio, Xiang Lan
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION Vol. 57 ( 27 ) page： 8100-8104 2018.7
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Biomimetic Synthesis and Structural Revision of Chaxine B and Its Analogues Reviewed
Hirata Yushi, Nakazaki Atsuo, Kawagishi Hirokazu, Nishikawa Toshio
ORGANIC LETTERS Vol. 19 ( 3 ) page： 560-563 2017.2
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Total Synthesis of Chiriquitoxin, an Analogue of Tetrodotoxin Isolated from the Skin of a Dart Frog Reviewed
Adachi, M.; Imazu, T.; Sakakibara, R.; Satake, Y.; Isobe, M.; Nishikawa, T.
Chem. Eur. J. Vol. 20 page： 1247-1251 2014
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A Synthetic Route of the Saxitoxin Skeleton: Synthesis of Decarbamoyl-α-saxitoxinol, an Analog of Saxitoxin Produced by the Cyanobacterium Lyngbya wollei Reviewed
Angew. Chem. Int. Ed Vol. 50 page： 7176-7178 2011
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*Synthetic Studies and biosynthetic speculation on marine alkaloid chartelline Reviewed
S. Kajii, T. Nishikawa, M. Isobe
Chem. Commun. page： 3121-3123 2008
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*An Efficient Total Synthesis of Optically Active Tetrodotoxin from Levoglucosenone Reviewed
51. Urabe, D.; Nishikawa, T.; Isobe, M.
Chemistry, An Asian Journal Vol. 1 page： 125-135 2006
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The First Asymmetric Total Synthesis of Tetrodotoxin Reviewed
Ohyabu, N.; Nishikawa, T.; Isobe, M.
Journal of American Chemical Society Vol. 125 page： 8798-8805 2003
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Asymmetric Total Synthesis of 11-Deoxytetrodotoxin
"Nishikawa, T.; Asai, M.; Isobe, M."
Journal of the American Chemical Society Vol. 124 page： 7847-7852 2002.5
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Stereocotrolled Synthesis of (-)-5.11-dideoxytetrodotoxin. Reviewed
Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Isobe, M.
Angewandte Chemie International Edition Vol. 38 page： 3081-3084 1999
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Isolation of Paraphaeoketones: A Plausible Biosynthetic Explanation for Paraphaeolactones via a Benzilic Acid Rearrangement Rather than a Favorskii Rearrangement. Reviewed
Oinuma Y, Kanehara R, Maeda H, Nishikawa T, Konno K, Tanaka K, Hashimoto M
Journal of natural products Vol. 87 ( 4 ) page： 1159 - 1170 2024.4
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The odor of a nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, is detected by specific olfactory sensory neurons of the green spotted puffers. Reviewed
Suzuki T, Nakahigashi R, Adachi M, Nishikawa T, Abe H
Chemical senses Vol. 49 2024.1
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5, 6, 11-trideoxy tetrodotoxin attracts tiger puffer Takifugu rubripes. Reviewed
Miyazaki K, Suo R, Itoi S, Hirota J, Adachi M, Miyasaka T, Nishikawa T, Yokoyama T, Sato S, Takada K
Toxicon : official journal of the International Society on Toxinology Vol. 237 page： 107539 2024.1
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Distribution of tetrodotoxin and its analogs in the toxic flatworm Planocera multitentaculata from Honshu Island, Japan Reviewed
Suo, R.; Tanaka, M.; Asano, M.; Nakahigashi, R.; Adachi, M.; Nishikawa, T.; Ogiso, S.; Matsubara, H.; Suzuki, N.; Itoi, S.
Fisheries Science Vol. 20 2024
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Total Synthesis of 19-Nordigitoxigenin, An Antiaroside Y Aglycon. Reviewed
Matsumura T, Nishikawa T, Nakazaki A
The Journal of organic chemistry Vol. 88 ( 21 ) page： 15142 - 15150 2023.11
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Assessing the safety and suitability of using silver vine as an olfactory enrichment for cats. Reviewed International coauthorship
Uenoyama R, Ooka S, Miyazaki T, Mizumoto H, Nishikawa T, Hurst JL, Miyazaki M
iScience Vol. 26 ( 10 ) page： 107848 2023.10
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Geographical differences in the composition of tetrodotoxin and 5,6,11-trideoxytetrodotoxin in Japanese pufferfishes and their origins. Reviewed
Ito M, Shirai K, Oyama H, Yasukawa S, Asano M, Kihara M, Suo R, Sugita H, Nakahigashi R, Adachi M, Nishikawa T, Itoi S
Chemosphere Vol. 336 page： 139214 2023.9
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The Asymmetric Total Synthesis and Configuration Confirmation of Aplysiaenal and Nhatrangin A, Truncated Derivatives of Aplysiatoxin and Oscillatoxin. Reviewed
Morishita M, Hada K, Kita M, Nishikawa T
Journal of natural products Vol. 86 ( 4 ) page： 1033 - 1041 2023.4
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Levels of Tetrodotoxins in Spawning Pufferfish, Takifugu alboplumbeus. Reviewed
Asano M, Ishizaki C, Tomonou T, Kihara M, Ito M, Yasukawa S, Shirai K, Oyama H, Izawa S, Kawamura R, Saito K, Suo R, Nakahigashi R, Adachi M, Nishikawa T, Sugita H, Itoi S
Marine drugs Vol. 21 ( 4 ) 2023.3
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An Asymmetric Total Synthesis of Picrotoxinin through a Mizoroki–Heck Reaction Reviewed
Matsumura, T.; Nishikawa, T.; Nakazaki, A.
Vol. 34 2023
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A Convergent Synthesis of Tetracyclic Indole Compounds by a Palladium-Catalyzed Cross-Coupling and Tandem Cyclization Reaction Reviewed
Ono, Y.; Higuchi, K.; Yamaguchi, M.; Sugino, K.; Nakazaki, A.; Adachi, M.; Nishikawa, T.
Synlett Vol. 34 page： 364 - 368 2023
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7-Epi-30-Methyloscillatoxin D from an Okinawan Cyanobacterium Okeania hirsuta Reviewed International coauthorship
Kanda, N.; Zhang, B-T.; Shinjo, A.; Kamiyama, M.; Nagai, H.; Uchida, H.; Araki, Y.; Nishikawa, T.; Satake, M.
Natural Product Communications Vol. 18 page： 1 - 5 2023
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Changes in Tissue Distribution of Tetrodotoxin and Its Analogues in Association with Maturation in the Toxic Flatworm, Planocera multitentaculata. Reviewed International coauthorship
Oyama H, Ito M, Suo R, Goto-Inoue N, Morisasa M, Mori T, Sugita H, Mori T, Nakahigashi R, Adachi M, Nishikawa T, Itoi S
Marine biotechnology (New York, N.Y.) 2022.11
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Tetrodotoxins in the flatworm Planocera multitentaculata.
Suo R, Tanaka M, Oyama H, Kojima Y, Yui K, Sakakibara R, Nakahigashi R, Adachi M, Nishikawa T, Sugita H, Itoi S
Toxicon : official journal of the International Society on Toxinology Vol. 216 page： 169 - 173 2022.9
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Structural verification of petromyzestrosterol by total syntheses of both C14-epimers of its 3-<i>O</i>-methyl derivative. Reviewed
Nakazaki A, Kawai M, Nishikawa T
Organic & biomolecular chemistry Vol. 20 ( 32 ) page： 6432 - 6435 2022.8
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Total Syntheses of the Proposed Biosynthetic Intermediates of Tetrodotoxin Tb-210B, Tb-226, Tb-242C, and Tb-258. Reviewed
Vol. 87 ( 14 ) page： 9023 - 9033 2022.7
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Domestic cat damage to plant leaves containing iridoids enhances chemical repellency to pests. Reviewed International coauthorship
Uenoyama R, Miyazaki T, Adachi M, Nishikawa T, Hurst JL, Miyazaki M
iScience Vol. 25 ( 7 ) page： 104455 2022.7
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Local Differences in the Toxin Amount and Composition of Tetrodotoxin and Related Compounds in Pufferfish (<i>Chelonodon patoca</i>) and Toxic Goby (<i>Yongeichthys criniger</i>) Juveniles. Reviewed International coauthorship
Ito M, Furukawa R, Yasukawa S, Sato M, Oyama H, Okabe T, Suo R, Sugita H, Takatani T, Arakawa O, Adachi M, Nishikawa T, Itoi S
Toxins Vol. 14 ( 2 ) 2022.2
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Green spotted puffers detect a nontoxic TTX analog odor using crypt olfactory sensory neurons. Reviewed
Suzuki T, Nakahigashi R, Adachi M, Nishikawa T, Abe H
Chemical senses Vol. 47 2022.1
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The Synthesis of simplified analogues of crambescin B carboxylic acid and their inhibitory activity of voltage-gated sodium channels: new aspects of atructure-activity relationships. Reviewed
Nakazaki, A.; Mouri, S.; Nakane, Y.; Ishikawa, Y.; Yamashira,M.; Nishikawa, T.
Heterocycles 2022
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Synthesis of the 8-Deoxy Analogue of 4,9-Anhydro-10-hemiketal-5-deoxy-tetrodotoxin, a Proposed Biosynthetic Precursor of Tetrodotoxin. Reviewed
Miyasaka T, Adachi M, Nishikawa T
Organic letters Vol. 23 ( 23 ) page： 9232 - 9236 2021.12
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Total synthesis and biological evaluation of oscillatoxins D, E, and F. Reviewed
Araki Y, Hanaki Y, Kita M, Hayakawa K, Irie K, Nokura Y, Nakazaki A, Nishikawa T
Bioscience, biotechnology, and biochemistry Vol. 85 ( 6 ) page： 1371 - 1382 2021.5
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Total Synthesis of the Cardiotonic Steroid (+)-Cannogenol. Reviewed
Watanabe S, Nishikawa T, Nakazaki A
The Journal of organic chemistry Vol. 86 ( 4 ) page： 3605 - 3614 2021.2
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Biomimetic Synthesis of the CDE Ring Moiety of Physalins, Complex 13,14-Secosteroids. Reviewed
Araki Y, Nakazaki A, Nishikawa T
Organic letters Vol. 23 ( 3 ) page： 989 - 994 2021.2
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First Detection of Tetrodotoxins in the Cotylean Flatworm <i>Prosthiostomum trilineatum</i>. Reviewed
Suo R, Kashitani M, Oyama H, Adachi M, Nakahigashi R, Sakakibara R, Nishikawa T, Sugita H, Itoi S
Marine drugs Vol. 19 ( 1 ) 2021.1
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Synthesis of the 8-Deoxy Analogue of 4,9-Anhydro-10-hemiketal-5-deoxy-tetrodotoxin, a Proposed Biosynthetic Precursor of Tetrodotoxin. Reviewed
(1) Miyasaka, T.; Adachi, M.; Nishikawa, T.
Org. Lett. Vol. 23 page： 9232 - 9236 2021
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Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions. Reviewed
Hanaki, Y., Araki, Y., Nishikawa, T., Yanagita, R. C.
Fundam. Toxicol. Sci. Vol. 8 ( 3 ) page： 69 - 73 2021
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Total Synthesis and biological evaluation of oscillatoxins D, E, and F. Reviewed
Araki, Y.; Hanaki, Y.; Kita, M.; Hayakawa, K.; Irie, K.; Nokura, Y.; Nakazaki, A.; Nishikawa, T.
Biosci. Biotechnol. Biochem. Vol. 85 ( 6 ) page： 1371 - 1382 2021
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Oscillatoxin E and Its C7 Epimer Show Distinct Growth Inhibition Profiles against Several Cancer Cell Lines. Reviewed
Hanaki, Y., Araki, Y., Nishikawa, T., Yanagita, R. C.
Heterocycles Vol. 102 ( 12 ) page： 2353 - 2362 2021
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Biosynthesis of Indole Diterpene Lolitrems: Radical-Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton. Reviewed
Jiang Y, Ozaki T, Harada M, Miyasaka T, Sato H, Miyamoto K, Kanazawa J, Liu C, Maruyama JI, Adachi M, Nakazaki A, Nishikawa T, Uchiyama M, Minami A, Oikawa H
Angewandte Chemie (International ed. in English) Vol. 59 ( 41 ) page： 17996 - 18002 2020.10
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Studies toward the Synthesis of Chartelline C. Reviewed
Nakane Y, Nakazaki A, Nishikawa T
The Journal of organic chemistry Vol. 85 ( 11 ) page： 7534 - 7542 2020.6
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New Synthetic Method for Efficient Synthesis of Bioactive Natural Products -Biomimetic Synthesis of Chaxines- Reviewed
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN Vol. 78 ( 6 ) page： 566 - 574 2020.6
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Biomimetic Synthesis of Chaxine and its Related Compounds. Reviewed
Niki M, Hirata Y, Nakazaki A, Wu J, Kawagishi H, Nishikawa T
The Journal of organic chemistry Vol. 85 ( 7 ) page： 4848 - 4860 2020.4
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Synthesis of Oxy-Functionalized Steroidal Skeletons via Mizoroki-Heck and Intramolecular Diets-Alder Reactions Reviewed
Watanabe Shogo, Nishikawa Toshio, Nakazaki Atsuo
ORGANIC LETTERS Vol. 21 ( 18 ) page： 7410 - 7414 2019.9
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Asymmetric Synthesis of the Aromatic Fragment of Sespendole Reviewed
Ono Yoshiki, Nakazaki Atsuo, Ueki Kaori, Higuchi Keiko, Sriphana Uraiwan, Adachi Masaatsu, Nishikawa Toshio
JOURNAL OF ORGANIC CHEMISTRY Vol. 84 ( 15 ) page： 9750 - 9757 2019.8
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Concise Stereocontrolled Synthesis of an alpha-Carbagalactose Segment of RCAI-56, a Candidate Anticancer Agent Reviewed
Ushida Naoki, Nagai Nobukazu, Adachi Masaatsu, Nishikawa Toshio
SYNLETT Vol. 30 ( 8 ) page： 977-981 2019.5
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Total Syntheses and Determination of Absolute Configurations of Cep-212 and Cep-210, Predicted Biosynthetic Intermediates of Tetrodotoxin Isolated from Toxic Newt Reviewed
Adachi Masaatsu, Miyasaka Tadachika, Kudo Yuta, Sugimoto Keita, Yotsu-Yamashita Mari, Nishikawa Toshio
ORGANIC LETTERS Vol. 21 ( 3 ) page： 780 - 784 2019.2
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A concise synthesis of peramine, a metabolite of endophytic fungi.
Ito S, Yamamoto Y, Nishikawa T
Bioscience, biotechnology, and biochemistry Vol. 82 ( 12 ) page： 2053 - 2058 2018.12
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Toward a Synthesis of Fawcettimine-Type Lycopodium Alkaloids: Stereocontrolled Synthesis of a Functionalized Azaspirocycle Precursor
Huang Wen-Yu, Nishikawa Toshio, Nakazaki Atsuo
JOURNAL OF ORGANIC CHEMISTRY Vol. 83 ( 18 ) page： 11108 - 11117 2018.9
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Semi-synthesis and Structure-Activity Relationship of Neuritogenic Oleanene Derivatives
Bian Linglin, Cao Shining, Cheng Lihong, Nakazaki Atsuo, Nishikawa Toshio, Qi Jianhua
CHEMMEDCHEM Vol. 13 ( 18 ) page： 1972-1977 2018.9
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SYNTHESIS OF DIBROMO COMPOUNDS CONTAINING 2,6-DIOXABICYCLO[3.1.1]HEPTANE SIMILAR TO CORE MOIETY OF THROMBOXANE A(2)
Nokura Yoshihiko, Nakazaki Atsuo, Nishikawa Toshio
HETEROCYCLES Vol. 96 ( 1 ) page： 127-136 2018.1
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Spiro Bicyclic Guanidino Compounds from Pufferfish: Possible Biosynthetic Intermediates of Tetrodotoxin in Marine Environments.
113. Ueyama, N.; Sugimoto, K.; Kudo, Y.; Onodera, K.; Cho, Y.; Konoki, K.; Nishikawa, T.; Yotsu-Yamashita, M.
Chem. Eur. J. Vol. 24 page： 7250 – 7258 2018
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Synthetic Route to Oscillatoxin D and Its Analogues
Nokura Yoshihiko, Araki Yusuke, Nakazai Atsuo, Nishikawa Toshio
ORGANIC LETTERS Vol. 19 ( 21 ) page： 5992 - 5995 2017.11
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Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Na(v)1.1 to Na(v)1.7)
Tsukamoto Tadaaki, Chiba Yukie, Wakamori Minoru, Yamada Tomoshi, Tsunogae Shunsuke, Cho Yuko, Sakakibara Ryo, Imazu Takuya, Tokoro Shouta, Satake Yoshiki, Adachi Masaatsu, Nishikawa Toshio, Yotsu-Yamashita Mari, Konoki Keiichi
BRITISH JOURNAL OF PHARMACOLOGY Vol. 174 ( 21 ) page： 3881-3892 2017.11
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Concise Synthesis of a Cyclopentane Intermediate Possessing All Nitrogen Functionalities for Pactamycin
Matsumoto Nobuyuki, Nakazaki Atsuo, Nishikawa Toshio
SYNLETT Vol. 28 ( 17 ) page： 2303-2306 2017.10
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De Novo Synthesis of Possible Candidates for the Inagami-Tamura Endogenous Digitalis-like Factor
Nakazaki Atsuo, Hashimoto Keiko, Ikeda Ai, Shibata Takahiro, Nishikawa Toshio
JOURNAL OF ORGANIC CHEMISTRY Vol. 82 ( 17 ) page： 9097 - 9111 2017.9
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New regiocontrolled syntheses of pyrrolopyrazinones and its application to the synthesis of peramine
Yamamoto Yuta, Nakazaki Atsuo, Nishikawa Toshio
TETRAHEDRON Vol. 73 ( 25 ) page： 3443-3451 2017.6
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Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B
Tsukamoto Tadaaki, Chiba Yukie, Nakazaki Atsuo, Ishikawa Yuki, Nakane Yoshiki, Cho Yuko, Yotsu-Yamashita Mad, Nishikawa Toshio, Wakamori Minoru, Konoki Keiichi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Vol. 27 ( 5 ) page： 1247-1251 2017.3
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Palladium-Catalyzed Cascade Wacker/Allylation Sequence with Allylic Alcohols Leading to Allylated Dihydropyrones. Reviewed
Huang, W.-Y.; Nishikawa, T.; Nakazaki, A.
ACS Omega ( 2 ) page： 487-495 2017.2
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One-Step Transformation of Trichloroacetamide into Isonitrile
Adachi Masaatsu, Miyasaka Tadachika, Hashimoto Honoka, Nishikawa Toshio
ORGANIC LETTERS Vol. 19 ( 2 ) page： 380-383 2017.1
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Concise Synthesis of a Cyclopentane Intermediate Possessing All nitrogen Functionalities for Pactamycin. Reviewed
Matsumoto, N.; Nakazaki, A.; Nishikawa, T.
Synlett Vol. 28 ( 17 ) page： 2303-2306 2017
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New regiocontrolled syntheses of pyrrolopyrazinones and its application to the synthesis of peramine. Reviewed
Yamamoto, Y.; Nakazaki, A.; Nishikawa, T.
Tetrahedron ( 73 ) page： 3443-3451 2017
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Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B. Reviewed
Tsukamoto, T.; Chiba, Y.; Nakazaki, A.; Ishikawa, Y.; Nakane, Y.; Cho, Y.; Nishikawa, T.; Yotsu-Yamashita, M.; Wakamori, M.; Konoki K.
Med. Chem. Lett ( 27 ) page： 1247-1251 2017
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Biomimetic Synthesis and Structural Revision of Chaxine B and Its Analogues. Reviewed
Hirata, Y.; Nakazaki, A.; Kawagishi, H.; Nishikawa, T.
Org. Lett. ( 19 ) page： 560-563 2017
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A Synthetic Strategy for Saxitoxin Skeleton by a Cascade Bromocyclization: Total Synthesis of (+)-Decarbamoyl-α-saxitoxinol. Reviewed
Ueno, S.; Nakazaki, A.; Nishikawa, T.
Org. Lett. ( 18 ) page： 6368-6371 2016
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A Divergent Approach to the Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from Atropisomeric N-Aryl Oxindole Derivatives. Reviewed
Nakazaki, A.; Mori, A.; Kobayashi, S.; Nishikawa, T
Chem. Asian J. ( 11 ) page： 3267-3274 2016
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One-pot non-enzymatic formation of firefly luciferin in a neutral buffer fromp-benzoquinone and cysteine. Reviewed
Kanie S.; Nishikawa T.; Ojika M.; Oba Y.
Scientific Reports Vol. 24794 ( 6 ) 2016
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Asymmetric synthesis of crambescin A-C carboxylic acids and their inhibitory activity on voltage-gated sodium channels. Reviewed
Nakazaki A.; Nakane Y.; Ishikawa Y.; Yotsu-Yamashita M.; Nishikawa T.
Org. Biomol. Chem. ( 14 ) page： 5304-5309 2016
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Improved Syntheses of (+)-Iridomyrmecin and (-)-Isoiridomyrmecin, Major Components of Matatabilactone. Reviewed
Adachi M.; Miyazawa Y.; Nishikawa, T.
Natural Product Communications 2016 ( 11 ) page： 883-886 2016
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Multifunctionality of the N-Trichloroacetyl Group Developed in the Synthesis of Tetrodotoxin, a Puffer Fish Toxin Reviewed
(1) Toshio Nishikawa, Daisuke Urabe, Masaatsu Adachi, Minoru Isobe
Synlett Vol. 26 page： 1930-1939 2015.5
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Synthesis of a C-N Axially Chiral N-Aryl Isatin through Asymmetric Intramolecular N-Arylation Reviewed
Nakazaki, A.; Miyagawa, K.; Nishikawa, T.
Eur. J. Org. Chem. page： 4603–4606 2015
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Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from N-Aryl-3-Chlorooxindoles Reviewed
Nakazaki, A.; Miyagawa, K.; Nishikawa, T.
Synlett ( 26 ) page： 1116-1120 2015
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Stereocontrolled Synthesis of ABC-tricycle of Solanoeclepin A. Reviewed
Adachi, M.; Torii, M.; Nishikawa, T.
Synlett ( 26 ) page： 965-969 2015
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Unexpected Metal-Free Transformation of gem-Dibromomethylenes to Ketones under Acetylation Conditions. Reviewed
Kimura, R.; Sawayama, Y.; Nakazaki, A.; Miyamoto, K.; Uchiyama, M.; Nishikawa, T.
Chem. Asian J. ( 10 ) page： 1035-1041 2015
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Synthesis of 1.5-dioxaspiro[3.4]octane through bromocation-induced cascade cyclization Reviewed
Nakazaki, A.; Nakane, Y.; Ishikawa, Y.; Nishikawa, T.
Heterocycles Vol. 91 page： 1157- 2015
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Synthesis of crambescin B carboxylic acid,a potent inhibitor of voltage-gated sodium channels Reviewed
Atsuo Nakazaki, Yuki Ishikawa, Yusuke Sawayama, Mari Yotsu-Yamashita Toshio Nishikawa
Org. Biomol. Chem. ( 12 ) page： 53–56 2014
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Synthesis of 5- and 8-Deoxytetrodotoxin Reviewed
Satake, Y.: Adachi, M.; Tokoro, S.; Yotsu-Yamashita, M.; Isobe M.; Nishikawa, T.
Chem. Asian J. Vol. 9 page： 1922-1932 2014
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Synthesis of 5,6,11-Trideoxytetrodotoxin Reviewed
Adachi M.: Sakakibara, R.; Satake, Y.; Isobe, M.; Nishikawa, T.
Chem. Lett. Vol. 43 page： 1719-1721 2014
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A New Deprotection of MTM Ether. Reviewed
Adachi M.; Hashimoto, H.; Sakakibara, R.; Imazu, T.; Nishikawa, T.
Synlett page： 2498-2502 2014
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An improved synthesis of (-)-5,11-Dideoxytetrodotoxin Reviewed
Adachi, M.; Imazu, T.; Isobe, M.; Nishiakwa. T.
J. Org. Chem. Vol. 78 page： 1699-1705 2013
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First Identification of 5,11-Dideoxytetrodotoxin in Marine Animals, and Characterization of Major Fragment Ions of Tetrodotoxin and Its Analogs by High Resolution ESI-MS/MS Reviewed
Mari Yotsu-Yamashita, Yuka Abe, Yuta Kudo, Raphael Ritson-Williams, Valerie J. Paul,Keiichi Konoki, Yuko Cho, Masaatsu Adachi, Takuya Imazu, Toshio Nishikawa, Minoru Isobe.
Mar. Drugs ( 11 ) page： 2799-2813 2013
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Stereocontrolled Total synthesis of Polygalolide A. Reviewed
Yamada, H. Adachi, M.; Isobe, M.; Nishikawa, T.
Chem. Asian J. ( 8 ) page： 1428-1435 2013
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Structure Study on a naturally Occurring Terphenyl Quinone Reviewed
Nakazaki, A.; Huang, W-Y.; Koga K.; Yingyongnarongkul B-E.; Boonsombat J.; Sawayama Y.; Tsujimoto T.; Nishikawa, T.
Biosci. Biotechnol. Biochem. ( 77 ) page： 1529-1532 2013
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Synthesis of Tetracyclic Indoline and Indolenine Derivatives Having β-Lactam Using Amphiphilic Reactivity of 2-Methylindolenine Reviewed
Nakazaki, A.; Hara, Y.; Kajii, S.; Nishikawa, T
Heterocycles Vol. 87 page： 611-625 2013
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Stereocontrolled Synthesis of an Indole Moiety of Sespendole and Stereochemical Assignment of the Side Chain Reviewed
Adachi, M.; Higuchi, K.; Thasana, N.; Yamada, H.; Nishikawa, T.
Org. Lett. Vol. 14 page： 144-117 2012
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Synthetic studies on pactamycin, a potent antitumor antibiotic Reviewed
51. Matsumoto, N.; Tsujimoto, T.; Nakazaki, A.; Isobe M.; Nishikawa, T.
RSC, Advances Vol. 2 page： 9448-9462 2012
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Bromocyclization of Alkynyl Guanidine: A New Approach to the Synthesis of Cyclic Guanidines of Saxitoxin Reviewed
page： 651-654 2011.2
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Synthetic Study on Sespendole, an Indole Sesquiterpene Alkaloid: Stereocontrolled Synthesis of the Sesquiterpene Segment Bearing All Requisite Stereogenic Centers. Reviewed
Sugino, K.; Nakazaki, A.; Isobe, M.; Nishikawa, T.
page： 647-650 2011.2
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Dynamic Chirality Determines Critical Roles for Bioluminescence in Symplectin–Dehydrocoelenterazine System Reviewed
68. V. Kongjinda, Y. Nakashima, N.Tani, M. Kuse, T. Nishikawa, Chin-Hui Yu, N. Harada, M. Isobe
Vol. 6 page： 2080-2091 2011
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Concise Synthesis of Deformylflustrabromine, a Marine Indole Alkaloid Through Propargyl Dicobalt Hexacarbonyl Complex Reviewed
Isaji, H.; Nakazaki, A.; Isobe, M.; Nishikawa, T.
Vol. 40 page： 1079-1081 2011
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A New Ring Expansion for a Chiral Hexahydroazulene Skeleton Possessing an Angular Methyl Group Reviewed
70. Adachi, M.; Komada, T.; Nishikawa, T.
J. Org. Chem. Vol. 76 page： 6942-6945 2011
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Total Synthesis of Polygalolide A Reviewed
Adachi, M.; Yamada, H.; Isobe,M.; Nish1ikawa, T.
Org. Lett. Vol. 24 page： 6532-6535 2011
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Identification of a Fluorescent Compound in the Cuticle of the Train Millipede Parafontaria laminata armigera. Reviewed
Kuse, M.; Yanagi, M.; Tanaka, E.; Tani, N.; Nishikawa, T.
Biosci. Biotechnol. Biochem. Vol. 74 page： 2307-2309 2010.10
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Synthesis of an Advanced Intermediate Bearing Two Hydroxy Groups for (-)-Tetrodotoxin and Its Analogs Reviewed
Nishikawa, T.; Koide, Y.; Adachi, M.; Isobe, M.
Bull. Chem. Soc. Jpn. Vol. 86 page： 66-68 2010
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Scalable Synthesis of a New Dihydroxylated Intermediate for tetrodotoxin and Its Analogues Reviewed
atake, Y.; Nishikawa, T.; Hiramatsu, T.; Araki, H.; Isobe, M.
Synthesis page： 1992-1998 2010
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Syntheses of N-Acylosoxazolidine derivatives, related to a partial strycture found in zetekitoxin AB, a Golden Frog Poison Reviewed
Nishikawa, T.; Urabe, D.; Isobe, M.
Heterocycles Vol. 79 page： 379-385 2009
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Dehydrocoelenterazine Is the Organic Substance Constituting the Prosthetic Group of Pholasin Reviewed
Tanaka, E.; Kuse, M.; Nishikawa, T.
ChemBioChem, Vol. 10 page： 2725-2729 2009
-
Selective Oxidation by the Hydroperoxide in the Photoprotein, Aequorin Reviewed
12. Doi, I.; Kuse, M.; Nishikawa, T.; Isobe, M.
Bioorg. Med. Chem. Vol. 17 page： 3399-3404 2009
-
Synthesis of Four Lysine-Linked Cereulide Analogs showing K+ Ionophoric Activity as Lead Compounds for Emetic Toxin-Detection by Immunoassays. Reviewed
Makarasen, A.; Nishikawa, T.; Isobe, M.
Synthesis page： 2184-2204 2009
-
Imino-O-Tosylate in Suzuki-Miyaura Reaction for substitution of the Pyrazine Rings: A Study for the Synthesis of Coelenterazine Analogs. Reviewed
Makarasen, A.; Kuse, M.; Nishikawa, T.; Isobe, M.
Bull. Chem. Soc. Jpn. Vol. 82 page： 870-878 2009
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Pholasin luminescence is enhanced by addition of dehydrocoelenterazine Reviewed
Kuse, M.; Tanaka, E.; Nishikawa, T.
Bioorganic & Medicinal Chemistry Letters Vol. 18 page： 5657-5659 2008.6
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Regioselectivity of Larock Indole Synthesis by Using Functionalized Alkynes Reviewed
Sugino, K.; Yoshimura, H.; Nishikawa, T.; Isobe, M.
Bioscience, Biotechnology & Biochemistry Vol. 72 page： 594-597 2008.4
-
Synthesis of N-hydroxyenamide, a potential precursor of chertelline
S. Kajii, T. Nishikawa, M. Isobe
Tetrahedron Letters Vol. 49 page： 594-597 2008
-
Synthesis of beta-Analogues of C-Mannosyltryptophan, a Novel C-Glycosylamino Acid Found in Proteins Reviewed
50. Nishikawa, T.; Koide, Y.; Kanakubo, A.; Yoshimura, H.; Isobe, M.
Organic Biochemical Chemistry Vol. 4 page： 1268-1277 2006
-
Syntheses of Naturally Occurring Terphenyls and Its Related Compounds, Reviewed
Sawayama, Y.; Tsujimoto, T.; Sugino, K.; Nishikawa, T.; Isobe., M.; Kawagishi, H
Bioscience, Biotechnology & Biochemistry Vol. 70 ( 12 ) page： 2998-3003 2006
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*One-Pot Transformation of Trichloroacetamide into Readily Deprotectable Carbamates Reviewed
Nishikawa, T.; Urabe, D.; Tomita, M.; Tsujimoto, T.; Iwabuchi, T.; Isobe, M.
Organic Letters Vol. 8 page： 3263-3265 2006
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*Stereocontrolled Synthesis of alfa-C-Mannosyltryptohan and its Analogues. Reviewed
Nishikawa, T.; Koide, Y.; Kajii, S.; Wada, K.; Ishikawa, M., Isobe, M.
Organic Biochemical Chemistry Vol. 3 page： 687-700 2005
-
Synthesis of Functionalized Cyclopentane for Pactamycin, A potent Antitumor Antibiotic Reviewed
Tsujimoto, T.; Nishikawa, T.; Urabe, D.; Isobe, M.
Synlett page： 433-436 2005
-
A Novel and Highly Stereoselective Carbon-chain Extension Reaction at the C-6 Position of 1,6-Anhydropyranose Reviewed
Nishikawa, T.; Mishima, M.; Ohyabu, N.; Isobe, M.
Tetrahedron Letters Vol. 45 page： 175-178 2004
-
A novel deprotection of trichloroacetamide, Reviewed
Urabe, D.; Sugino K.; Nishikawa, T.; Isobe, M.
Tetrahedron Letters Vol. 45 page： 9405-9407 2004
-
Novel Synthesis of Bromoindolenine with Spiro-b-lactam in Chartelline. Reviewed
Nishikawa, T.; Kajii, S.; Isobe, M.
Synlett page： 2025-2027 2004
-
*An efficient total synthesis of optically active tetrodotoxin. Reviewed
Nishikawa, T.; Urabe, D.; Isobe,
Angewante. Chemie International Edition Vol. 43 page： 4782-4785 2004
-
Synthesis of Model Compound Containing an Indole Spiro-b-lactam Moiety with Vinylchloride in Chartellines Reviewed
Nishikawa, T.; Kajii, S.; Isobe, M.
Chemistry Letters Vol. 33 page： 440-441 2004
-
a-C-Mannnosyltryptophan is not recognized by conventional mannose-binding lectins Reviewed
Nishikawa, T.; Kajii, S.; Sato, C.; Yasukawa, Z.; Kitajima, K.; Isobe, M.
Bioorganic Medicinal Chemistry Vol. 12 page： 2343-2348 2004
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Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analog of Puffer Fish Toxin Reviewed
Nishikawa, T.; Urabe, D.; Yoshida, K.; Iwabuchi, T.; Asai, M.; Isobe, M
Chemistry, A European Journal Vol. 10 page： 452-462 2004
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Biological activity of 8,11-dideoxytetrodotoxin: Lethality to mice and the inhibitory activity to cytotoxicity of ouabain and veratridine in mouse neuroblastoma cells, Neuro-2a Reviewed
Yotsu-Yamashita, M.; Urabe, D.; Asai, M.; Nishikawa, T.; Isobe M.
Toxicon Vol. 42 page： 557-560 2003
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"Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, Unnatural Analog of Puffer Fish Toxin"
Nishikawa, T.; Urabe, D.; Yoshida, K.; Iwabuchi, T.; Asai, M.; Isobe, M.
Organic Letters Vol. 4 page： 2679-2682 2002.7
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Scandium Perchlorate as a Superior Lewis Acid for Regioselective Ring Opening of Aziridine Carboxylate with Indoles
Nishikawa, T.; Kajii, S.; Wada, K.; Ishikawa, M.; Isobe, M.
Synthesis Vol. 1658－1662 2002.1
-
Synthesis of Novel α-C-Glycosylamino Acids and Reverse Regioselectivity in Larock's Heteroannulation for the Synthesis of the Indole Nucleus
Nishikawa, T.; Wada, K.; Isobe, M.
Bioscience, Biotechnology & Biochemistry" Vol. 66 page： 2273-2278 2002.1
-
Total Synthesis of a-C-Mannosyltryptophan.
Nishikawa, T.; Ishikawa, M.; Wada, K.; Isobe, M.
Synlett page： 945-947 2001.7
-
"Stereocontrolled Synthesis of (-)-5,11-Dideoxytetrodotoxin."
"M. Asai, T. Nishikawa, N. Ohyabu, N. Yamamoto, M. Isobe"
Tetrahedron Vol. 57 page： 4543-4558 2001.4
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Synthesis of Common Key Intermediate for (-)-Tetrodotoxin and its Analogs
"Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Fukuda, Y.; Isobe, M."
Tetrahdron Vol. 57 page： 3875-3883 2001.4
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Stereoselektive Synthese von (-)-5.11-didesoxytetrodotoxin.
"Nishikawa, T.; Asai, M.; Ohyabu, N.; Yamamoto, N.; Isobe, M."
Angewandte Chemie Vol. 111 page： 3268-3271 1999.11
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Hydrosilylation of acetylenes with catalytic biscobalthexacarbonyl complex and its application to heteroconjugate addition methodology.
"Isobe, M.; Nishizawa, R.; Nishikawa, T.; Yoza, K."
Tetrahedron Letters Vol. 40 page： 6927-6930 1999.5
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Electronic Factors in the C-Glycosidation with Silylacetylene. Reviewed
"29. Isobe, M.; Saeeng, R.; Nishizawa, R.; Konobe, M.; Nishikawa, T."
Chemistry Letters page： 467-468 1999.3
-
Palladium Catalyzed Substitution Reaction of Allylic Derivatives with Tinacetylene
"Nishikawa T.; Isobe, M."
"Bioscience, Biotechnology & Biochemistry" Vol. 63 page： 238-242 1999.1
-
New Synthetic Route for Guanidine from Trichloroacetamide for Tetrodotoxin and its Related Compounds.
"Nishikawa, T.; Ohyabu, N.; Yamamoto, N. ; Isobe, M."
Tetrahedron Vol. 55 page： 4325-4340 1999.1
-
Synthesis of α-C-Mannosyltryptophan Derivative, Naturally Occurring C-Glycosyl Amino Acid Found in Human Ribonuclease." Reviewed
"Nishikawa, T.; Ishikawa, M.; Isobe, M."
Synlett page： 123-125 1999.1
-
Stereocontrolled Synthesis and Reactivity of Sugar Acetylene.
"6. Isobe, M.; Nishizawa, R.; Hosokawa, S.; Nishikawa, T."
"Journal of Chemical Society, Chemical Communications" page： 2665-2676 1998.1
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Improved Coitions for Facile Overman Rearrangement.
"Nishikawa, T., Asai, M., Ohyabu, N. and Isobe, M.,"
Journal of Organic Chemistry Vol. 63 page： 188-192 1998.1
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Novel Stereoselective Reaction of Levoglucosenone with Furfural.
"Nishikawa, T., Araki, H. and Isobe, M.,"
"Bioscience, Biotechnology & Biochemistry" Vol. 62 (#1) page： 190-192 1998.1
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Stereoelectronic a Steric Control in Chiral Cyclohexane Synthesis toward (-)-Tetrodotoxin.
"Bamba, M., Nishikawa, T. and Isobe, M.,"
Tetrahedron Vol. 54 page： 6639-6650 1998.1
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Stereoelectronic a Steric Effects for Critical Oxidation to the Cyclohexane Derivatives for an Intermediate to (-)-Tetrodotoxin. Reviewed
"Bamba, M., Nishikawa, T. and Isobe, M.,"
Synlett page： 371-372 1998.1
-
Stereoelectronic and Steric Control in Chiral Cyclohexane Synthesistoward (-)-Tetrodotoxin(共著)
Bamba, M.; Nishikawa, T.; Isobe, M.
Tetrahedron Vol. 54 ( 24 ) page： 6639-6650 1998
-
Stereocontrolled Synthesis and Reactivity of Sugar Acetylene Reviewed
Isobe, M.; Nishizawa, R.; Hosokawa, S.; Nishikawa, T.
Journal of Chemical Society,Chemical Communications page： 2665-2676 1998
-
Synthesis a Biological Evaluation of Novel Cyclic Enediyne Compous Related to Dynemicin A as Antitumor Agents. Reviewed
"Unno, R., Michishita, H., Inagaki, H., Baba, Y., Jomori, T., Nishikawa, T. and Isobe, M.,"
Chemical & Pharmaceutical Bulletin Vol. 45 page： 125-133 1997.1
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Structure-Activity Relationships of Cyclic Enediynes Related to Dynemicin A. Part 2: Synthesis a Antitumor Activity of 9- a 12-Substituted Enediynes. Reviewed
"Unno, R., Michishita, H., Inagaki, H., Suzuki, Y., Baba, Y., Jomori, T., Moku, M., Nishikawa, T. and Isobe, M.,"
Bioorganic & Medicinal Chemistry Vol. 5 page： 903-919 1997.1
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Structure-Activity Relationships of Cyclic Enediynes Related to Dynemicin A. Part 1: Synthesis a Antitumor Activity of 9-Acetoxy Enediyne Equipped with Aryl Carbamate Moieties. Reviewed
"Unno, R., Michishita, H., Inagaki, H., Suzuki, Y., Baba, Y., Jomori, T., Nishikawa, T. and Isobe, M.,"
Bioorganic & Medicinal Chemistry Vol. 5 page： 883-901 1997.1
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Synthesis a Antitumor Effects of Water-Soluble Enediyne Compous Related to Dynemicin A.
"Unno, R., Michishita, H., Inagaki, H., Suzuki, Y., Baba, Y., Jomori, T., Nishikawa, T. and Isobe, M,"
Bioorganic & Medicinal Chemistry Vol. 5 page： 987-999 1997.1
-
"Enzyme inhibitors, synthesis and approach to mechanism." Invited Reviewed
"Isobe, M., Tsuboi, K., Hosokawa, S., Bamba, M., Kira, K., Shibuya, S., Ohtani, I.I., Nishikawa, T. and Ichikawa, Y."
Pure & Applied Chemistry Vol. 69 page： 401-406 1997
-
"Tin-Assisted Cyclization for Chiral Cyclohexane Synthesis, An Alternative Route to (-)-Tetrodotoxin Skeleton."
"Bamba, M., Nishikawa, T. and Isobe, M.,"
Tetrahedron Letters Vol. 37 (#45) page： 8199-8202 1996.1
-
Synthesis of Anthraquinone Part of Dynemicin A via Diels-Alder Reaction.
"Nishikawa, T., Moku, M., Suzuki, Y. and Isobe, M.,"
Chemistry Letters Vol. (#2) page： 113-114 1996.1
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Synthesis a Biological Evaluation of Both Enantiomers of Dynemicin A Model Compou.
"Nishikawa, T., Yoshikai, M., Obi, K., Kawai, T., Unno, R., Jomori, T. and Isobe, M.,"
Tetrahedron Vol. 51 page： 9339-9352 1995.1
-
Synthesis of Bicyclic Hydroxy Lactone Intermediate toward (-)-Tetrodotoxin.
Yamamoto, N., Nishikawa, T. and Isobe, M.
Synlett page： 505-506 1995
-
Synthesis and Biological Evaluation of Both Enantiomers of Dynemicin A Model Compound Reviewed
Tetrahedron Vol. 51 page： 9339 1995
-
Synthetic Studies on Antibiotic Dynemicin A. Synthesis of Cyclic Enediyne Model Compound of Dynemicin A Reviewed
Nishikawa, T.; Ino, A.; Isobe, M.
Tetrahedron Vol. 50 page： 1449-1468 1994
-
Cesium Fluoride Promoted Cyclization in the Synthesis of Enediyne Antibiotics Reviewed
Nishikawa, T.; Shibuya S.; Isobe, M.
Synlett page： 482-484 1994
-
One Pot Synthesis of Haloacetylenes from Trimethylsilylacetylene Reviewed
Nishikawa, T.; Shibuya S.; Hosokawa, S.; Isobe, M.
Synlett page： 485-486 1994
-
Synthesis of Both Enantiomers of Dynemicin A Model Compound. New Remote Asymmetric Induction in Acetylide Addition into Quinoline Nucleus as Key Step.
Nishikawa, T.; Yoshikai, M.; Obi, K.; Isobe, M.
Tetrahedron Letters Vol. 35 page： 7997-8000 1994
-
Synthetic Studies on Dynemicin A. New Quinoline Synthesis for C, D and E rings.
Nishikawa, T.; Isobe, M.
Tetrahedron Vol. 50 page： 5621-5632 1994
-
Methodologies for Synthesis of Heterocyclic Compounds. Invited Reviewed
Isobe, M.; Nishikawa, T.; Yamamoto, N.; Tsukiyama, T.; Ino, A.; Okita, T.
Journal of Heterocyclic Chemistry, Vol. 29 page： 619-625 1992
-
Silyl and Tin Acetylene as Nucleophile toward Acyliminium Cation, a Plausible Key Reaction for Dynemicin, Enediyne Antitumor Antibiotic Reviewed
Nishikawa, T.; Isobe, M.; Goto, T.
Synlett page： 99-101 1991
-
Synthetic Studies on the Bicyclo[7,3,1]-tridecendiyne System in an Antitumor Antibiotic, Dynemicin A Reviewed
Nishikawa, T.; Isobe, M.; Goto, T.
Synlett page： 393-394 1991
-
Synthesis of a Simple Model Compound of Dynemicin and Cycloaromatization with Pinacol-Pinacolone Rearrangement in the strained Enediyne Medium Ring Reviewed
Nishikawa, T.; Ino, A.; Isobe; M.; Goto, T.
Chemistry Letters page： 1271-1274 1991
-
Synthetic Studies on (-)-Tetrodotoxin(3)-Nitrogenation through Overman Rearrangement and Guanidine Ring Formation Reviewed
Tetrahedron Letters Vol. 31 page： 3327-3330 1990
-
Methodology for Stereochemical Control in Bioactive Natural Product Synthesis --- New Methods toward Enediyne Antitumor Antibiotics. Invited Reviewed
Isobe, M.; Nishikawa, T.; Herunsalee, A.; Tsukiyama, T.; Hirose, Y.; Shimokawa, K.; Goto, T.
Pure & Applied Chemistry Vol. 62 page： 2007-2012 1990
-
Asymmetric Synthesis via Heteroconjugate Addition-Valinol Template as Oxazolidine Heteroolefine vs Acetylenic Nucleophiles Reviewed
Isobe, M.; Hirose, Y.; Shimokawa, K.; Nishikawa, T.; Goto, T.
Tetrahedron Letters Vol. 31 page： 5499-5502 1990
-
Synthesis of Chiral Cyclohexanes from Levoglucosenone and its Application to an Indole Alkaloid Reserpine Reviewed
Isobe, M.; Fukami, N.; Nishikawa, T.; Goto, T.
Heterocyles Vol. 25 page： 521-532 1987
-
Synthetic Studies on a Stereochemically Complex Natural Product : Designs for the Total Synthesis of (-)-Tetrodotoxin Invited Reviewed
Isobe, M.; Nishikawa, T.; Fukami, N.; Goto, T.
Pure & Applied Chemistry Vol. 59 page： 399-406 1987
-
Synthetic Studies on Tetrodotoxin [1] --- Stereocontrolled Synthesis of the Cyclohexane Moiety Reviewed
Isobe, M.; Nishikawa, T.; Pikul, S.; Goto, T.
Tetrahedron Letters Vol. 28 page： 6485-6488 1987