研究者詳細 - 松島　充代子

論文 - 松島　充代子

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Observation of Fine Lung Structure by Ultrahigh-Resolution Optical Coherence Tomography Using 800, 1060, and 1300nm Supercontinua 査読有り

Ishida S, Nishizawa N, Kitatsuji M, Ohshima H, Hasegawa Y, Matsushima M, Kawabe T.

Jpn. J. Appl. Phys 51 巻頁： 047001 2012年3月

Attenuation of TGF-beta-Stimulated Collagen Production in Fibroblasts by Quercetin-Induced HO-1. 査読有り

Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, Shimokata K, Hasegawa Y, Kawabe T.

Am J Respir Cell Mol Biol 44 巻 ( 5 ) 頁： 614-620 2011年5月

Comparison of salivary cortisol, heart rate, and oxygen saturation between early skin-to-skin contact with different initiation and duration times in healthy, full-term infants 査読有り

Takahashi Y, Tamakoshi K, Matsushima M, Kawabe T.

Early Hum. Dev 87 巻 ( 3 ) 頁： 151-157 2011年3月

Characteristics of an optimized catheter-type thermal flow sensor for measuring reciprocating airflows in bronchial pathways 査読有り

Shikida M, Yokota T, Kawabe , Funaki T, Matsushima M, Iwai S, Matsunaga N, Sato K

Micromech. Microen 20 巻 ( 12 ) 頁： 1-11 2010年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

We optimized a catheter-type thermal flow sensor to measure the reciprocating airflows in
bronchial pathways. The electrical wiring in the outer tube was extracted to keep the symmetry
of the temperature distribution on the heaters. First, a flexible sensor was fabricated on
polyimide film with photolithography, and then the enameled wires were bonded to the contact
pads on the film with anisotropic conductive film. The film sensor was finally assembled with
a catheter configuration that had a diameter of 1.8 mm by applying a heat shrinkable tube. We
experimentally confirmed that the sensor outputs under both forward and reverse flow
conditions had the same output characteristics when a design with symmetrical heating
elements was applied. The sensor outputs we obtained at a reciprocating flow frequency
ranging from 1 to 3 Hz almost coincided, and they also fit that obtained under unidirectional
airflow conditions. Finally, the aspirated- and inspired-air characteristics in the air passages of
small laboratory animals (rats and mice) were measured. Due to our development of a flexible
method of electrical wiring, we could try a new approach to intubation measurements in which
the sensor was inserted into the air passage from the mouth with a fiberscope, and we
confirmed that the sensor we developed was able to directly measure the breathing
characteristics in air passages. Implanted measurements were also attempted in this study.
(Some figures in this article are in colour only in the electronic version)

DOI： 10.1088/0960-1317/20/12/125030

Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues 査読有り

Hirayama T, Kawabe T, Matsushima M, Nishimura Y, Kobe Y, Ota Y, Baba K, Takagi K

Peptides 31 巻 ( 11 ) 頁： 2109-2113 2010年11月

*Heme Oxygenase-1 Mediates the Anti-allergic Actions of Quercetin in Rodent Mast Cells 査読有り

Matsushima M., Takagi K., Ogawa M., Hirose E., Ota Y., Abe F., Baba K., Hasegawa T., Hasegawa Y., Kawabe T.

Inflammation Research 58 巻 ( 10 ) 頁： 705-715 2009年10月

Peptide array-based analysis of the specific IgE and IgG4 in cow's milk allergens and its use in allergy evaluation 査読有り

Matsumoto N, Okochi M, Matsushima M, Kato R, Takase T, Yoshida Y, Kawase M, Isobe KI, Kawabe T, Honda H.

Peptides 30 巻 ( 10 ) 頁： 1840-1847 2009年10月

Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species 査読有り

Ogasawara N., Oguro T., Sakabe T., Matsushima M., Takikawa O., Isobe KI., Nagase F.

J. Cell. Biochem. 108 巻 ( 3 ) 頁： 716-725 2009年10月

Involvement of Heme Oxygenase-1 in Kaempferol-induced Anti-allergic Actions in RBL-2H3 Cells 査読有り

Matsushima M., Hirose E., Takagi K., Ota Y., Ishigami K., Hirayama T., Hayashi Y., Nakamura T., Hashimoto N., Imaizumi K., Baba K., Hasegawa Y., Kawabe T.

Inflammation 32 巻 ( 2 ) 頁： 99-108 2009年4月

Inhibition of Degranulation by Myricetin-induced Heme Oxygenase-1 in Mast Cells 査読有り

Ota Y., Matsushima M., Ogawa M., Hirose E., Hirayama T., Yuasa E., Yabuta K., Baba K., Hasegawa Y., Takagi K., Kawabe T

Occupational and Environmental Allergy 16 巻 ( 2 ) 頁： 61-73 2009年4月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Myricetin is one of the flavonoids with a variety of cytoprotective and immuno-modulatory functions. It provides their cytoprotective actions via activation of specific transcriptional factors and upregulation of endogenous defensive pathways. Although myricetin is also known to inhibit degranulation from mast cells, its mechanism is poorly understood. In this study, we investigated the involvement of heme oxygenase-1 (HO-1) induced by myricetin in degranulation of rat basophilic leukemia (RBL-2H3) cells. Our results demonstrated upregulation of heme oxygenase activity after short exposure to myricetin, followed by the induction of HO-1 expression in protein levels after long exposure to myricetin. The HO-1 inhibitor, SnPP, inhibited suppression of degranulation by myricetin from RBL-2H3 cells. Nuclear factor erythroid-2 related factor 2 (Nrf2) was translocated to nucleus by myricetin. These findings suggest that myricetin exerts anti-allergic actions via activation of HO-1-Nrf2 pathway. This study may well lead to promising new therapeutic strategies by flavonoid-HO-1 pathway in allergic inflammation.

Development of peptide arrays for detection of IgE-binding epitopes in cow's milk allergens 査読有り

Matsumoto N., Okochi M., Matsushima M., Ogawa A., Takase T., Yohida Y., Kawase M., Isobe K., Kawabe T., Honda H.

Journal of Bioscience and Bioengineering 107 巻 ( 3 ) 頁： 324-330 2009年3月

Xenin and xenopsin induce histamine release from rat peritoneal mast cells 査読有り

Matsushima M., Kitaichi k., Kawabe T., Suzuki R., Baba K., Hasegawa T., Takagi K.

Occupational and Environmental Allergy 14 巻 ( 2 ) 頁： 60-67 2007年4月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Xenin is a 25-amino acid peptide that was identified in human gastric mucosa during a search for a human counterpart of xenopsin, a 8-amino acid peptide, originally found in the skin of xenopus laevis. Xenin is also structurally related to the ileal and hypothalamic 13-amino acid peptide, neurotensin. The common amino acids on C-terminus that xenin, xenopsin and neurotensin share determine biological activities, such as contractions of the gastrointestinal tract and stimulation of pancreatic exocrine secretion. However, little is known about the effects of xenin and xenopsin on host immune systems. Thus we conducted a series of in vitro experiments with rat peritoneal mast cells to determine whether xenin or xenopsin has a histamine-releasing effect on mast cells. Xenin (10-8 to 10-5 M) induced histamine release in a dose-dependent manner. Xenopsin also induced histamine release from rat peritoneal mast cells. Xenin-induced (10-6 M) histamine release was inhibited by adding extracellular Ca2+ (0.5 to 2 mM) and benzalkonium chloride (1 to 5 microM), a selective inhibitor of Gi type G proteins. Histamine release induced by xenopsin-induced (10-4 M) histamine release also was inhibited by adding extracellular Ca2+ (0.5 to 2 mM) and benzalkonium chloride (1 to 5 microM). These results suggest that xenin and xenopsin induced histamine release in a fashion involving extracellular Ca2+- and Gi-dependent pathway similar to other endogenous peptides that induce histamine release and might play a role at the site of inflammation and /or immune response.

Increased plasma concentration and brain penetration of methamphetamine in behaviorally sensitized rats 査読有り

Kitaichi K., Morishita Y., Doi Y., Ueyama J., Matsushima M., Takagi K., Hasegawa T.

Eur J Pharmacol 464 巻頁： 39-48 2003年3月

The mRNA expression of calcitonin receptor-like receptor/receptor activity modifying proteins in rat peritoneal mast cells 査読有り

Matsushima M., Kitaichi K., Tatsumi Y., Hasegawa T., Takagi K.

Eur J Pharmacol 464 巻頁： 111-114 2003年3月

Platelet factor 4 fragment induces histamine release from rat peritoneal mast cells 査読有り

Suzuki R., Kimura T., Kitaichi K., Tatsumi Y., Matsushima M., Shibata E., Zhao Y. L., Baba K., Hasegawa T., Takagi K.

Peptides 23 巻頁： 1713-1717 2002年10月

Induction of histamine release from rat peritoneal mast cells by histatins 査読有り

Yoshida M., Kimura T., Kitaichi K., Suzuki R., Baba K., Matsushima M., Tatsumi Y., Shibata E., Takagi K., Hasegawa T., Takagi K.

Biol Pharm Bull 24 巻頁： 1267-1270 2001年11月

Quercetin protects against pulmonary oxidant stress via heme oxygenase-1 induction in lung epithelial cells 査読有り

Hayashi Y, Matsushima M, Nakamura T, Shibasaki M, Hashimoto N, Imaizumi K, Shimokata K, Hasegawa Y, Kawabe T.

Biochem Biophys Res Commun 417 巻 ( 1 ) 頁： 169-174 2012年1月

Degranulation and expression of cytokines were modulated by diazinon in activated mast cells. 査読有り国際誌

Ohdachi T, Matsushima M, Ohara M, Kawashima H, Inoue G, Atsumi K, Tsubosaki Y, Takekoshi M, Ueyama J, Hashimoto N, Sato M, Hasegawa Y, Ishii M, Kawabe T

Toxicology 506 巻頁： 153882 2024年8月

Decrease in cholesterol in the cell membrane is essential for Nrf2 activation by quercetin. 査読有り国際誌

The Journal of nutritional biochemistry 116 巻頁： 109329 2023年6月

Correlation of theophylline levels in rat exhaled breath and lung tissue after its intravenous injection 招待有り査読有り

Matsushima M, Tanihata S, Kusakabe J, Okahira M, Ito H, Yamamoto A, Yamamoto M, Yamamoto R, Kawabe T.

J Breath Res 16 巻 ( 3 ) 2022年5月

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