研究者詳細 - 井藤　彰

論文 - 井藤　彰

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Novel therapy for pancreatic fistula using adipose-derived stem cell sheets treated with mannose 査読有り

Kaneko Hirokazu, Kokuryo Toshio, Yokoyama Yukihiro, Yamaguchi Junpei, Yamamoto Tokunori, Shibata Rei, Gotoh Momokazu, Murohara Toyoaki, Ito Akira

SURGERY 161 巻 ( 6 ) 頁： 1561 - 1569 2017年6月

Effects of heat stimulation and L-ascorbic acid 2-phosphate supplementation on myogenic differentiation of artificial skeletal muscle tissue constructs 査読有り

Kazushi Ikeda, Akira Ito, Masanori Sato, Shota Kanno, Yoshinori Kawabe, Masamichi Kamihira

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE 11 巻 ( 5 ) 頁： 1322 - 1331 2017年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY

Although skeletal muscle tissue engineering has been extensively studied, the physical forces produced by tissue-engineered skeletal muscles remain to be improved for potential clinical utility. In this study, we examined the effects of mild heat stimulation and supplementation of a L-ascorbic acid derivative, L-ascorbic acid 2-phosphate (AscP), on myoblast differentiation and physical force generation of tissue-engineered skeletal muscles. Compared with control cultures at 37 degrees C, mouse C2C12 myoblast cells cultured at 39 degrees C enhanced myotube diameter (skeletal muscle hypertrophy), whereas mild heat stimulation did not promote myotube formation (differentiation rate). Conversely, AscP supplementation resulted in an increased differentiation rate but did not induce skeletal muscle hypertrophy. Following combined treatment with mild heat stimulation and AscP supplementation, both skeletal muscle hypertrophy and differentiation rate were enhanced. Moreover, the active tension produced by the tissue-engineered skeletal muscles was improved following combined treatment. These findings indicate that tissue culture using mild heat stimulation and AscP supplementation is a promising approach to enhance the function of tissue-engineered skeletal muscles. Copyright (C) 2015 John Wiley & Sons, Ltd.

DOI： 10.1002/term.2030

Web of Science

PubMed

Novel therapy for pancreatic fistula using adipose-derived stem cell sheets treated with mannose. 査読有り

Hirokazu Kaneko, Toshio Kokuryo, Yukihiro Yokoyama, Junpei Yamaguchi, Tokunori Yamamoto, Rei Shibata, Momokazu Gotoh, Toyoaki Murohara, Akira Ito, Masato Nagino

Surgery 161 巻 ( 6 ) 頁： 1561–1569 2017年

Multilayered adipose-derived regenerative cell sheets created by a novel magnetite tissue engineering method for myocardial infarction. 査読有り

Masakazu Ishii, Rei Shibata, Yuuki Shimizu, Takashi Yamamoto, Kazuhisa Kondo, Yoko Inoue, Noriyuki Ouchi, Tohru Tanigawa, Noriyoshi Kanemura, Akira Ito, Honda Honda, Toyoaki Murohara

International Journal of Cardiology. 175 巻 ( 3 ) 頁： 545-553 2014年

TLR4 and NLRP3 inflammasome activation 1 in monocytes by N-propionyl cysteaminylphenol-maleimid-dextran (NPCMD). 査読有り

Yu Mizote, Kazumasa Wakamatsu, Shosuke Ito, Akiko Uenaka, Yoshihiro Ohue, Koji Kurose, Midori Isobe, Akira Ito, Yasuaki Tamura, Hiroyuki Honda, Toshiharu Yamashita, Satoshi Nohara, Mikio Oka, Kowichi Jimbow, Eiichi Nakayama

Journal of Dermatological Science 73 巻 ( 3 ) 頁： 209-215 2014年

Heat-inducible gene expression system by applying alternating magnetic field to magnetic nanoparticles. 査読有り

Masaki Yamaguchi, Akira Ito, Akihiko Ono, Yoshinori Kawabe, Masamichi Kamihira

ACS Synthetic Biology 3 巻 ( 5 ) 頁： 273-279 2014年

Enhancement of contractile force generation of artificial skeletal muscle tissues by mild and transient heat treatment. 査読有り

Masanori Sato, Kazushi Ikeda, Shota Kanno, Akira Ito, Yoshinori Kawabe, Masamichi Kamihira

Current Pharmaceutical Biotechnology. 14 巻 ( 13 ) 頁： 1083-1087 2014年

T-cell receptor repertoires of tumor-infiltrating lymphocytes after hyperthermia using functionalized magnetite nanoparticles. 査読有り

Akira Ito, Masaki Yamaguchi, Noriaki Okamoto, Yuji Sanematsu, Yoshinori Kawabe, Kazumasa Wakamatsu, Shosuke Ito, Hiroyuki Honda, Takeshi Kobayashi, Eiichi Nakayama, Yasuaki Tamura, Masae Okura, Toshiharu Yamashita, Kowichi Jimbow, Masamichi Kamihira

Nanomedicine 8 巻 ( 6 ) 頁： 891-902 2013年

Melanoma-targeted chemo-thermotherapy and in situ peptide immunotherapy through HSP production by using melanogenesis substrate, NPrCAP and magnetite nanoparticles. 査読有り

Kowichi Jimbow, Yoshie Ishii-Osai, Shosuke Ito, Yasuaki Tamura, Akira Ito, Akihiro Yoneta, Takafumi Kamiya, Toshiharu Yamashita, Hiroyuki Honda, Kazumasa Wakamatsu, Katsutoshi Murase, Satoshi Nohara, Eiichi Nakayama, Takeo Hasegawa, Itsuo Yamamoto, Takeshi Kobayashi.

Journal of Skin Cancer 2013:742925. 巻 2013年

Effects of B-cell lymphoma 2 gene transfer to myoblast cells on skeletal muscle tissue formation using magnetic force-based tissue engineering. 査読有り

Masanori Sato, Akira Ito, Hirokazu Akiyama, Yoshinori Kawabe, Masamichi Kamihira

Tissue Engineering Part A 19 巻 ( 1-2 ) 頁： 307-315 2013年

Conjugation of magnetite nanoparticles with melanogenesis substrate, NPrCAP provides melanoma targeted, in situ peptide vaccine immunotherapy through HSP production by chemo-thermotherapy. 査読有り

Kowichi Jimbow, Yasuaki Tamura, Akihiro Yoneta, Takafumi Kamiya, Ichiro Ono, Toshiharu Yamashita, Akira Ito, Hiroyuki Honda, Kazumasa Wakamatsu, Shosuke Ito, Satoshi Nohara, Eiichi Nakayama and Takeshi Kobayashi

Journal of Biomaterials and Nanobiotechnology 3 巻頁： 140-153 2012年

Hollow fiber bioreactor perfusion culture system for magnetic force-based skeletal muscle tissue engineering. 査読有り

Yasunori Yamamoto, Akira Ito, Hideaki Jitsunobu, Katsuya Yamaguchi, Yoshinori Kawabe, Hiroshi Mizumoto, Masamichi Kamihira

Journal of Chemical Engineering of Japan 45 巻 ( 5 ) 頁： 348-354 2012年

Heat-inducible transgene expression system incorporating a positive feedback loop of transcriptional amplification for hyperthermia-induced gene therapy. 査読有り

Masaki Yamaguchi, Akira Ito, Noriaki Okamoto, Yoshinori Kawabe, Masamichi Kamihira

Journal of Bioscience and Bioengineering 114 巻 ( 4 ) 頁： 460-465 2012年

Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol, a tyrosinase substrate, in melanoma models. 査読有り

Shosuke Ito, Akira Nishigaki, Yasue Ishii-Osai, Makoto Ojika, Kazumasa Wakamatsu, Toshiharu Yamashita, Yasuaki Tamura, Akira Ito, Hiroyuki Honda, Eiichi Nakayama, Kouwichi Jimbow

Biochemical Pharmacology 84 巻 ( 5 ) 頁： 646-653 2012年

Heat-inducible transgene expression with transcriptional amplification mediated by a transactivator. 査読有り

Akira Ito, Noriaki Okamoto, Masaki Yamaguchi, Yoshinori Kawabe, Masamichi Kamihira

International Journal of Hyperthermia 28 巻 ( 8 ) 頁： 788-798 2012年

Oral immunotherapy for pollen allergy using T-cell epitope-containing egg white derived from genetically manipulated chickens. 査読有り

Yoshinori Kawabe, Yuuki Hayashida, Kensaku Numata, Shota Harada, Yoshifumi Hayashida, Akira Ito, Masamichi Kamihira

PLoS One 2012;7(10):e48512 巻 2012年

Enhanced liver functions in mouse hepatoma cells by induced overexpression of liver-enriched transcription factors. 査読有り

Hideaki Yamamoto, Yoshinori Kawabe, Akira Ito, Masamichi Kamihira

Biochemical Engineering Journal 60 巻 ( 15 ) 頁： 67-73 2012年

N-propionyl-4-S-cysteaminylphenol induces apoptosis in B16F1 cells and mediates tumor-specific T-cell immune responses in a mouse melanoma model. 査読有り

Yoshie Ishii-Osai, Toshiharu Yamashita, Yasuaki Tamura, Noriyuki Sato, Akira Ito, Hiroyuki Honda, Kazumasa Wakamatsu, Shosuke Ito, Eiichi Nakayama, Masae Okura, Kowichi Jimbow

Journal of Dermatological Science 67 巻頁： 51-60 2012年

Accumulation gene integration into a pre-determined site using Cre/loxP. 査読有り

Hirokazu Obayashi, Yoshinori Kawabe, Hirokazu Makitsubo, Ryoko Watanabe, Yujiro Kameyama, Shuohao Huang, Yutaka Takenouchi, Akira Ito, Masamichi Kamihira

Journal of Bioscience and Bioengineering 113 巻 ( 3 ) 頁： 381-388 2012年

Adeno-associated virus Rep-mediated targeting of integrase-defective retroviral vector DNA circles into human chromosome 19. 査読有り

Shuohao Huang, Yoshinori Kawabe, Akira Ito, Masamichi Kamihira

Biochemical and Biophysical Research Communications 417 巻 ( 1 ) 頁： 78-83 2012年

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