Faculty Profiles - ITO Akira

Papers - ITO Akira

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Bystander-killing effect and cyclic induction of TNF-alfa gene under heat inducible promoter gadd153. Reviewed

Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 90 ( 4 ) page： 437-441 2000

Heat-inducible TNF-alpha gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy. Reviewed

Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

Cancer Gene Therapy Vol. 8 ( 9 ) page： 649-654 2001

Effective solitary hyperthermia treatment of malignant glioma using stick type CMC-magnetite. In vivo study Reviewed

Ohno T, Wakabayashi T, Takemura A, Yoshida J, Ito A, Shinkai M, Honda H and Kobayashi T

Journal of Neuro-Oncology Vol. 56 ( 3 ) page： 233 2002

バイオターゲティングのための生体分子デザイン

井藤　彰、本多裕之、小林　猛

未来材料 Vol. 2 ( 8 ) page： 5 2002

リポソームを用いた腫瘍への薬剤ターゲティング

井藤　彰、本多裕之、小林　猛

Vol. 17 ( 4 ) page： 347 2002

Radiation-inducible TNF-a gene expression under stress-inducible promoter gadd153 for cancer therapy Reviewed

Akira Ito, Masashige Shinkai, Kazumi Hakamada, Hiroyuki Honda, Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 92 ( 6 ) page： 598 2001

Heat-inducible TNF-alpha gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy Reviewed

Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

Cancer Gene Therapy Vol. 8 ( 9 ) page： 649 2001

Augmentation of MHC class I antigen presentation via heat shock protein expression by hyperthermia Reviewed

Akira Ito, Masashige Shinkai, Hiroyuki Honda, Toshihiko Wakabayashi, Jun Yoshida, Takeshi Kobayashi

Cancer Immunology Immunotherapy Vol. 50 ( 10 ) page： 515 2001

Bystander-killing effect and cyclic induction of TNF-α gene under heat inducible promoter gadd153 Reviewed

Akira Ito, Masashige Shinkai, Isabelle Anne Bouhon, Hiroyuki Honda, Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 90 ( 4 ) page： 437 2000

Heat induction of reporter gene expression via the gadd 153 promoter and its possible application to hyperthermia treatment of cancer Reviewed

Isabelle Anne Bouhon, Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

Cytotechnology Vol. 33 ( 1 ) page： 131 2000

Introduction of TNF-α gene expression by heat inducible promoter gadd153 Reviewed

Akira Ito, Masashige Shinkai, Isabelle Anne Bouhon, Hiroyuki Honda, Takeshi Kobayashi

Japanese Journal of Hyperthermic Oncology Vol. 16 ( 2 ) page： 91 2000

Effective solitary hyperthermia treatment of malignant glioma using stick type CMC-magnetite. In vivo study. Reviewed

Takanari Ohno, Toshihiko Wakabayashi, Atsuhito Takemura, Jun Yoshida, Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

Journal of Neuro-Oncology Vol. 56 ( 5 ) page： 233-239 2000

Complete regression of mouse mammary carcinoma with a size greater than 15 mm by frequent repeated hyperthermia using magnetic nanoparticles. Reviewed

Akira Ito, Koji Tanaka, Hiroyuki Honda, Shigeru Abe, Hideyo Yamaguchi, Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 96 ( 4 ) page： 360-363 2003

ガン治療を目的とした遺伝子発現の誘導

新海政重、井藤　彰、イザベル　ブホン、本多裕之、小林　猛

ケミカルエンジニヤリング Vol. 44 page： 9 1999

All-In-One Magnetic Nanoparticles for Thermo-Immunotherapy of Malignant Melanoma

Kaneko, M; Saito, R; Nishikawa, A; Ito, A

ADVANCED HEALTHCARE MATERIALS page： e2500260 2025.3

Fabrication of phospholipid polymer-modified alginate hydrogels for bioartificial pancreas. Reviewed

Ryo Futatsubashi, Masahiro Kaneko, Akira Ito.

Journal of Bioscience and Bioengineering Vol. 139 ( 3 ) page： 242 - 248 2025.3

Amphiphilic phospholipid polymers as a cryoprotectant for vitrification and nanowarming of rat livers

Kaneko, M; Takizawa, N; Wakabayashi, T; Kaneoka, H; Ito, A

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 139 ( 1 ) page： 70 - 78 2025.1

Language：English Publisher：Journal of Bioscience and Bioengineering

Liver biobanking is a promising approach that saves the lives of patients with end-stage liver disease. Cryopreservation based on vitrification enables semi-permanent organ preservation, contributing to overcome the shortage of donors for liver transplants. A technical challenge in cryopreservation of transplantable organs lies in thawing methodology, and conventional convective warming cannot maintain the glassy state during thawing because of the large temperature gradient between the inner and outer parts of the organs, leading to ice formation and damage of cells in the organ. Nanowarming, in which magnetic nanoparticles are dispersed in a vitrification solution and heated by exposure of alternating magnetic field, can achieve uniform and rapid heating of organs. Herein, we report that amphiphilic phospholipid polymers composed of 2-methacryloyloxyethyl phosphorylcholine and n-butyl methacrylate can function as a cryoprotectant for nanowarming. The amphiphilic phospholipid polymers enhanced the viability of primary rat hepatocytes after vitrification. Moreover, the polymers enhanced the dispersion stability of magnetic nanoparticles in vitrification solution, and the perfusion of the vitrification solution with magnetic nanoparticles into rat livers through portal vein provided uniform distribution of the nanoparticles in the liver. After perfusion, the vitrified liver was successfully thawed rapidly and uniformly by nanowarming, which maintained tissue integrity and cell viability.

DOI： 10.1016/j.jbiosc.2024.10.003

Web of Science

Scopus

PubMed

Bone morphogenetic protein signaling inhibitor improves differentiation and function of 3D muscle construct fabricated using C2C12

Ding, R; Xi, Y; Ito, A; Shimizu, K; Nagamori, E; Fujita, H; Kawamoto, T; Horie, M

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 137 ( 6 ) page： 480 - 486 2024.6

Language：English Publisher：Journal of Bioscience and Bioengineering

Functional tissue-engineered artificial skeletal muscle tissue has great potential for pharmacological and academic applications. This study demonstrates an in vitro tissue engineering system to construct functional artificial skeletal muscle tissues using self-organization and signal inhibitors. To induce efficient self-organization, we optimized the substrate stiffness and extracellular matrix (ECM) coatings. We modified the tissue morphology to be ring-shaped under optimized self-organization conditions. A bone morphogenetic protein (BMP) inhibitor was added to improve overall myogenic differentiation. This supplementation enhanced the myogenic differentiation ratio and myotube hypertrophy in two-dimensional cell cultures. Finally, we found that myotube hypertrophy was enhanced by a combination of self-organization with ring-shaped tissue and a BMP inhibitor. BMP inhibitor treatment significantly improved myogenic marker expression and contractile force generation in the self-organized tissue. These observations indicated that this procedure may provide a novel and functional artificial skeletal muscle for pharmacological studies.

DOI： 10.1016/j.jbiosc.2024.03.005

Web of Science

Scopus

PubMed

Bone morphogenic protein signaling inhibitor improves differentiation and function of 3D muscle construct fabricated using C2C12 Reviewed

Ran Ding, Yuan Xi, Akira Ito, Kazunori Shimizu, Eiji Nagamori, Hideaki Fujita, Takuo Kawamoto, Masanobu Horie

Journal of Bioscience and Bioengineering Vol. 137 ( 6 ) page： 480 - 486 2024

Transplantable cell-encapsulation device using a semipermeable ethylene-vinyl alcohol copolymer membrane in a mouse diabetic model

Kaneko, M; Moriguchi, H; Futatsubashi, R; Ayano, S; Kobayashi, G; Ito, A

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 136 ( 5 ) page： 415 - 422 2023.11

Language：English Publisher：Journal of Bioscience and Bioengineering

Cell-based therapy is an attractive approach, and encapsulation of therapeutic cells is a promising strategy because it prevents immune responses and allows transplanted cells to be retrieved in case of dysfunction. Bioartificial pancreas, in which insulin-secreting cells are encapsulated in a semipermeable membrane bag, is a new class of medical device for treating type-I diabetes. In this study, we developed a macroencapsulation device in which the pancreatic beta cell line MIN6 was encapsulated in a semipermeable bag made of an ethylene-vinyl alcohol copolymer membrane. In vitro evaluation of ATP and insulin levels revealed that MIN6 cells grown in Matrigel within the device secreted insulin in response to glucose levels. Transplantation of the device lowered blood glucose levels for 30 days in diabetic mice. Histological observation revealed that MIN6 cells formed spheroids in Matrigel, and no host cells were detected within the device. Blood levels of inflammatory cytokines in the transplanted mice were similar to those in non-transplanted mice, and antibody levels in the device were lower than those in the intraperitoneal fluid. These results suggest that the semipermeable ethylene-vinyl alcohol copolymer membrane developed in this study is useful for cell encapsulation in cell-based therapies, including beta-cell macroencapsulation for type-1 diabetes.

DOI： 10.1016/j.jbiosc.2023.09.001

Web of Science

Scopus

PubMed

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