Faculty Profiles - ITO Akira

Papers - ITO Akira

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Bystander-killing effect and cyclic induction of TNF-alfa gene under heat inducible promoter gadd153. Reviewed

Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 90 ( 4 ) page： 437-441 2000

Heat-inducible TNF-alpha gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy. Reviewed

Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

Cancer Gene Therapy Vol. 8 ( 9 ) page： 649-654 2001

Effective solitary hyperthermia treatment of malignant glioma using stick type CMC-magnetite. In vivo study Reviewed

Ohno T, Wakabayashi T, Takemura A, Yoshida J, Ito A, Shinkai M, Honda H and Kobayashi T

Journal of Neuro-Oncology Vol. 56 ( 3 ) page： 233 2002

バイオターゲティングのための生体分子デザイン

井藤　彰、本多裕之、小林　猛

未来材料 Vol. 2 ( 8 ) page： 5 2002

リポソームを用いた腫瘍への薬剤ターゲティング Open Access

井藤　彰、本多裕之、小林　猛

Vol. 17 ( 4 ) page： 347 2002

Radiation-inducible TNF-a gene expression under stress-inducible promoter gadd153 for cancer therapy Reviewed

Akira Ito, Masashige Shinkai, Kazumi Hakamada, Hiroyuki Honda, Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 92 ( 6 ) page： 598 2001

Heat-inducible TNF-alpha gene therapy combined with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy Reviewed

Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

Cancer Gene Therapy Vol. 8 ( 9 ) page： 649 2001

Augmentation of MHC class I antigen presentation via heat shock protein expression by hyperthermia Reviewed Open Access

Akira Ito, Masashige Shinkai, Hiroyuki Honda, Toshihiko Wakabayashi, Jun Yoshida, Takeshi Kobayashi

Cancer Immunology Immunotherapy Vol. 50 ( 10 ) page： 515 2001

Bystander-killing effect and cyclic induction of TNF-α gene under heat inducible promoter gadd153 Reviewed

Akira Ito, Masashige Shinkai, Isabelle Anne Bouhon, Hiroyuki Honda, Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 90 ( 4 ) page： 437 2000

Heat induction of reporter gene expression via the gadd 153 promoter and its possible application to hyperthermia treatment of cancer Reviewed

Isabelle Anne Bouhon, Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

Cytotechnology Vol. 33 ( 1 ) page： 131 2000

Introduction of TNF-α gene expression by heat inducible promoter gadd153 Reviewed

Akira Ito, Masashige Shinkai, Isabelle Anne Bouhon, Hiroyuki Honda, Takeshi Kobayashi

Japanese Journal of Hyperthermic Oncology Vol. 16 ( 2 ) page： 91 2000

Effective solitary hyperthermia treatment of malignant glioma using stick type CMC-magnetite. In vivo study. Reviewed

Takanari Ohno, Toshihiko Wakabayashi, Atsuhito Takemura, Jun Yoshida, Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi

Journal of Neuro-Oncology Vol. 56 ( 5 ) page： 233-239 2000

Complete regression of mouse mammary carcinoma with a size greater than 15 mm by frequent repeated hyperthermia using magnetic nanoparticles. Reviewed

Akira Ito, Koji Tanaka, Hiroyuki Honda, Shigeru Abe, Hideyo Yamaguchi, Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 96 ( 4 ) page： 360-363 2003

ガン治療を目的とした遺伝子発現の誘導

新海政重、井藤　彰、イザベル　ブホン、本多裕之、小林　猛

ケミカルエンジニヤリング Vol. 44 page： 9 1999

Bone morphogenetic protein signaling inhibitor improves differentiation and function of 3D muscle construct fabricated using C2C12 Open Access

Seibutsu-kogaku Kaishi Vol. 104 ( 2 ) page： 57 - 57 2026.2

Magnetic Nanoparticle-mediated Hyperthermia: Recent Advances in Strategies for Systemic Delivery Open Access

KANEKO MASAHIRO, ITO AKIRA

Thermal Medicine Vol. 41 ( 4 ) page： 73 - 82 2025.12

Language：English Publisher：Japanese Society for Thermal Medicine

<p>Magnetic nanoparticle (MNP)-mediated hyperthermia is a promising approach for cancer therapy because it enables the local heating and killing of tumor cells. The systemic administration of MNPs via intravenous injection is crucial for the treatment of a wide range of cancers, including deep-seated tumors. However, the clinical translation of this technology is severely hampered by the extremely low efficiency of nanoparticle delivery to tumor tissues, which has been a major bottleneck limiting therapeutic efficacy. This review provides an overview of recent advances in strategies to overcome this challenge. We first discuss conventional drug delivery system approaches based on the enhanced permeability and retention effect, and then highlight key preclinical studies demonstrating the trend towards developing functional MNPs. Moreover, we explored emerging paradigms, such as the strategic manipulation of nanoparticle-blood protein interactions (protein corona formation) to control the <i>in vivo</i> biodistribution of nanoparticles and the recently proposed active transport and retention principle. Furthermore, we introduce strategies to maximize the local therapeutic efficacy once MNPs reach the tumor, including MNP-based platforms for controlled drug release, subcellular targeting of mitochondria, and the combination of hyperthermia with immunotherapy. The clinical success of magnetic hyperthermia depends on improving nanoparticle delivery to tumors based on a deeper understanding of biological interactions and enhancing the local therapeutic effect.</p>

DOI： 10.3191/thermalmed.41.73

Open Access

CiNii Research

Molecular Design of Catechol-Containing Phospholipid Polymers toward Effective Functionalization of Magnetic Nanoparticles for Cancer Hyperthermia. Reviewed Open Access

Masahiro Kaneko, Kanato Yukishita, Kaname Tsutsumiuchi, Akira Ito.

ACS Omega Vol. 10 ( 28 ) page： 30708 - 30716 2025.7

Molecular Design of Dual Redox-Active Phospholipid Polymers with a Potent Anticancer Activity Reviewed Open Access

Yuki Ogawa, Masahiro Kaneko, Akira Ito

ACS Applied Polymer Materials Vol. 7 ( 8 ) page： 5070 - 5076 2025.4

All-In-One Magnetic Nanoparticles for Thermo-Immunotherapy of Malignant Melanoma

Kaneko, M; Saito, R; Nishikawa, A; Ito, A

ADVANCED HEALTHCARE MATERIALS page： e2500260 2025.3

Fabrication of phospholipid polymer-modified alginate hydrogels for bioartificial pancreas. Reviewed

Ryo Futatsubashi, Masahiro Kaneko, Akira Ito.

Journal of Bioscience and Bioengineering Vol. 139 ( 3 ) page： 242 - 248 2025.3

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