Faculty Profiles - SAITO, Susumu

Papers - SAITO, Susumu

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Artificial photosynthesis directed toward organic synthesis Invited Reviewed

Shogo Mori, Riku Hashimoto, Takashi Hisatomi, Kazunari Domen, Susumu Saito

Nature Communications 2025.2

Selective electroreduction of CO2 to formate by a heterogenized Ir complex using H2O as an electron/hydrogen source Invited Reviewed

Jieun Jung, Keun Woo Lee, Naonari Sakamoto, Selvam Kaliyamoorthy, Taku Wakabayashi, Kenji Kamada, Keita Sekizawa, Shunsuke Sato, Tomiko M Suzuki, Takeshi Morikawa, Susumu Saito

EES Catalysis Vol. 3 page： 254 - 258 2025

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Royal Society of Chemistry (RSC)

A newly synthesized tetradentate PNNP-coordinated iridium (Ir) complex, Mes IrPPh2, immobilized on a carbon material, was found to be a superior catalyst for CO2 electrochemical reduction reaction (CO2ERR) to give...

DOI： 10.1039/d4ey00261j

(PNCP)Ir vs (PNNP)Ir: Neutral Iridium Complex for Direct Hydrogenation of Carboxylic Acids Invited Reviewed

Koichiro Nishimoto, Naoki Noto, Yohei Kametani, Bendik Gro̷mer, Chihaya Murata, Hiroko Okuwa, Yoshihito Shiota, Kazunari Yoshizawa, Susumu Saito

Organometallics Vol. 43 ( 23 ) page： 3013 - 3021 2024.10

Ferrocenyl PNNP Ligands-Controlled Chromium Complex-Catalyzed Photocatalytic Reduction of CO2 to Formic Acid Invited Reviewed

Taku Wakabayashi, Yohei Kametani, Eimi Tanahashi, Yoshihito Shiota, Kazunari Yoshizawa, Jieun Jung, Susumu Saito

Journal of the American Chemical Society Vol. 146 ( 38 ) page： 25963 - 25975 2024.9

Photocatalytic CO2 Reduction Using an Osmium Complex as a Panchromatic Self-Photosensitized Catalyst: Utilization of Blue, Green and Red light Reviewed

Kenji Kamada, Jieun Jung, Chihiro Yamada, Taku Wakabayashi, Keita Sekizawa, Shunsuke Sato, Takeshi Morikawa, Shunichi Fukuzumi, Susumu Saito

Angew. Chem. Int. Ed. Vol. 63 page： e202403866 - e202403866 2024.3

Machine Learning Classification for Predicting Catalytic Activity of Organic Photosensitizers in Nickel(II) Salt-Promoted Phenol Synthesis Reviewed

Naoki Noto, Akira Yada, Takeshi Yanai, Susumu Saito

Angew. Chem. Int. Ed. Vol. 62 page： e202219107 2023.1

Selective reduction of carboxylic acids to alcohols in the presence of alcohols by a dual bulky transition metal complex/Lewis acid catalyst Reviewed

Bendik Grømer, Shota Yoshioka, Susumu Saito*

ACS Catal. Vol. 12 page： 1957 - 1964 2022.1

Reaction of H2 with mitochondria-relevant metabolites using a multifunctional molecular catalyst Reviewed

Shota Yoshioka, Sota Nimura, Masayuki Naruto, Susumu Saito

Science Advances Vol. 6 ( 43 ) page： eabc0274 - eabc0274 2020.10

Language：English Publishing type：Research paper (scientific journal) Publisher：American Association for the Advancement of Science (AAAS)

The Krebs cycle is the fuel/energy source for cellular activity and therefore of paramount importance for oxygen-based life. The cycle occurs in the mitochondrial matrix, where it produces and transfers electrons to generate energy-rich NADH and FADH2, as well as C4-, C5-, and C6-polycarboxylic acids as energy-poor metabolites. These metabolites are biorenewable resources that represent potential sustainable carbon feedstocks, provided that carbon-hydrogen bonds are restored to these molecules. In the present study, these polycarboxylic acids and other mitochondria-relevant metabolites underwent dehydration (alcohol-to-olefin and/or dehydrative cyclization) and reduction (hydrogenation and hydrogenolysis) to diols or triols upon reaction with H2, catalyzed by sterically confined iridium–bipyridyl complexes. The investigation of these single–metal site catalysts provides valuable molecular insights into the development of molecular technologies for the reduction and dehydration of highly functionalized carbon resources.

DOI： 10.1126/sciadv.abc0274

Web of Science

Photocatalytic CO2 Reduction Using a Robust Multifunctional Iridium Complex toward the Selective Formation of Formic Acid Invited Reviewed

Kenji Kamada, Jieun Jung, Taku Wakabayashi, Keita Sekizawa, Shunsuke Sato, Takeshi Morikawa, Shunichi Fukuzumi, Susumu Saito

Journal of the American Chemical Society Vol. 142 ( 23 ) page： 10261 - 10266 2020.6

Catalytic hydrogenation of carboxylic acids using low-valent and high-valent metal complexes Invited Reviewed

Yoshioka, S; Saito, S

CHEMICAL COMMUNICATIONS Vol. 54 ( 95 ) 2018.12

Diboron-Catalyzed Dehydrative Amidation of Aromatic Carboxylic Acids with Amines Invited Reviewed

Sawant Dinesh N, Bagal Dattatraya B, Ogawa Saeko, Selvam Kaliyamoorthy, Saito Susumu

ORGANIC LETTERS Vol. 20 ( 15 ) page： 4397 - 4400 2018.8

N-Alkylation of functionalized amines with alcohols using a copper-gold mixed photocatalytic system Invited Reviewed

Lyu-Ming Wang, Yuna Morioka, Kellie Jenkinson, Andrew E. H. Wheatley, Susumu Saito, Hiroshi Naka

Scientific Reports Vol. 8 ( 1 ) 2018.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Nature Publishing Group

Direct functionalization of amino groups in complex organic molecules is one of the most important key technologies in modern organic synthesis, especially in the synthesis of bio-Active chemicals and pharmaceuticals. Whereas numerous chemical reactions of amines have been developed to date, a selective, practical method for functionalizing complex amines is still highly demanded. Here we report the first late-stage N-Alkylation of pharmaceutically relevant amines with alcohols at ambient temperature. This reaction was achieved by devising a mixed heterogeneous photocatalyst in situ prepared from Cu/TiO2 and Au/TiO2. The mixed photocatalytic system enabled the rapid N-Alkylation of pharmaceutically relevant molecules, the selective mono-and di-Alkylation of primary amines, and the non-symmetrical dialkylation of primary amines to hetero-substituted tertiary amines.

DOI： 10.1038/s41598-018-25293-z

Web of Science

Scopus

PubMed

Photocatalytic hydrogenolysis of allylic alcohols for rapid access to platform chemicals and fine chemicals Invited Reviewed

Yuki Takada, Joaquim Caner, Hiroshi Naka, Susumu Saito

Pure and Applied Chemistry Vol. 90 ( 1 ) page： 167 - 174 2018.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Walter de Gruyter GmbH

A brief account of our recent work on the chemo-, regio- and stereoselective photocatalytic hydrogenolysis of allylic alcohols to alkenes promoted by palladium-loaded titanium oxide (Pd/TiO2) photocatalysts is presented. Since methanol is employed as the reducing agent, the method does not involve stoichiometric generation of salt waste. The photocatalytic hydrogenolysis proceeds at room temperature, and is compatible with the presence of functional groups such as C=C double bonds and hydroxyl groups at non-allylic positions. The regioselectivity is predictable: the hydrogen atom is predominantly incorporated into the sterically less hindered carbon atom of the allylic moiety. This protocol should provide straightforward green access to a range of platform chemicals (exemplified by the two-step synthesis of propylene from glycerol) and fine chemicals [e.g. (S)-(+)-lavandulol from (R)-(-)-carvone] without the need for protection/deprotection steps.

DOI： 10.1515/pac-2017-0501

Web of Science

Scopus

Catalytic transformation of functionalized carboxylic acids using multifunctional rhenium complexes Invited Reviewed

Masayuki Naruto, Santosh Agrawal, Katsuaki Toda, Susumu Saito

SCIENTIFIC REPORTS Vol. 7 2017.6

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Carboxylic acids (CAs) are one of the most ubiquitous and important chemical feedstocks available from biorenewable resources, CO2, and the petrochemical industry. Unfortunately, chemoselective catalytic transformations of CHnCO2H (n = 1-3) groups into other functionalities remain a significant challenge. Herein, we report rhenium(V) complexes as extremely effective precatalysts for this purpose. Compared to previously reported heterogeneous and homogeneous catalysts derived from high- or low-valent metals, the present method involves a alpha-C-H bond functionalization, a hydrogenation, and a hydrogenolysis, which affords functionalized alcohols with a wide substrate scope and high chemoselectivity under relatively mild reaction conditions. The results represent an important step toward a paradigm shift from 'low-valent' to 'high-valent' metal complexes by exploring a new portfolio of selective functional group transformations of highly oxygenated organic substrates, as well as toward the exploitation of CAs as a valuable biorenewable feedstock.

DOI： 10.1038/s41598-017-03436-y

Web of Science

PubMed

Multifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine-ruthenium framework Invited Reviewed

Takashi Miura, Masayuki Naruto, Katsuaki Toda, Taiki Shimomura, Susumu Saito

SCIENTIFIC REPORTS Vol. 7 2017.5

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Amides are ubiquitous and abundant in nature and our society, but are very stable and reluctant to salt-free, catalytic chemical transformations. Through the activation of a "sterically confined bipyridineruthenium (Ru) framework (molecularly well-designed site to confine adsorbed H-2 in)" of a precatalyst, catalytic hydrogenation of formamides through polyamide is achieved under a wide range of reaction conditions. Both C=O bond and C-N bond cleavage of a lactam became also possible using a single precatalyst. That is, catalyst diversity is induced by activation and stepwise multiple hydrogenation of a single precatalyst when the conditions are varied. The versatile catalysts have different structures and different resting states for multifaceted amide hydrogenation, but the common structure produced upon reaction with H-2, which catalyzes hydrogenation, seems to be "H-Ru-N-H."

DOI： 10.1038/s41598-017-01645-z

Web of Science

PubMed

Cationic mononuclear ruthenium carboxylates as catalyst prototypes for self-induced hydrogenation of carboxylic acids Reviewed

Masayuki Naruto, Susumu Saito

NATURE COMMUNICATIONS Vol. 6 page： 8140 2015.8

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Carboxylic acids are ubiquitous in bio-renewable and petrochemical sources of carbon. Hydrogenation of carboxylic acids to yield alcohols produces water as the only byproduct, and thus represents a possible next generation, sustainable method for the production of these alternative energy carriers/platform chemicals on a large scale. Reported herein are molecular insights into cationic mononuclear ruthenium carboxylates ([Ru(OCOR)](+)) as prototypical catalysts for the hydrogenation of carboxylic acids. The substrate-derived coordinated carboxylate was found to function initially as a proton acceptor for the heterolytic cleavage of dihydrogen, and subsequently also as an acceptor for the hydride from [Ru-H](+), which was generated in the first step (self-induced catalysis). The hydrogenation proceeded selectively and at high levels of functional group tolerance, a feature that is challenging to achieve with existing heterogeneous/homogeneous catalyst systems. These fundamental insights are expected to significantly benefit the future development of metal carboxylate-catalysed hydrogenation processes of bio-renewable resources.

DOI： 10.1038/ncomms9140

Web of Science

PubMed

Dehydrative synthesis of chiral oxazolidinones catalyzed by alkali metal carbonates under low pressure of CO2 Invited Reviewed

Siong Wan Foo, Yuki Takada, Yusuke Yamazaki, Susumu Saito

TETRAHEDRON LETTERS Vol. 54 ( 35 ) page： 4717 - 4720 2013.8

Language：English Publishing type：Research paper (scientific journal) Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Dehydrative synthesis of oxazolidinones from amino alcohols and CO2 was achieved in the presence of alkali metal carbonates such as Cs2CO3 as catalyst. It is noteworthy that 1 atm of CO2 is enough for the reaction to proceed and no special dehydrating agent is required in this system. A mechanstic study showed that the OH of amino alcohol acts as nucleophile and the OH in the carbamic acid moiety is liberated during the cyclization process. (C) 2013 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2013.06.100

Web of Science

Catalytic hydrogenation of unactivated amides enabled by hydrogenation of catalyst precursor Invited Reviewed

Takashi Miura, Ingmar E. Held, Shunsuke Oishi, Masayuki Naruto, Susumu Saito

TETRAHEDRON LETTERS Vol. 54 ( 21 ) page： 2674 - 2678 2013.5

Language：English Publishing type：Research paper (scientific journal) Publisher：PERGAMON-ELSEVIER SCIENCE LTD

A general method for catalytic hydrogenation of unactivated amides was achieved. During the catalyst induction period, a novel structural change was observed involving full hydrogenation of the interior unsaturated bonds of the pyridines of the Ru-containing catalyst precursor. Based on this observation, the mechanism of amide hydrogenation may involve a two-step pathway, wherein the Ru catalyst having an H-Ru-N-H functionality is generated in the first step, followed by the amide carbonyl group interacting with the outer, rather than the inner, sphere of the Ru catalyst. (c) 2013 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2013.03.047

Web of Science

Aldol condensation of amides using phosphazene-based catalysis Invited Reviewed

Siong Wan Foo, Shun Oishi, Susumu Saito

TETRAHEDRON LETTERS Vol. 53 ( 40 ) page： 5445 - 5448 2012.10

Language：English Publishing type：Research paper (scientific journal) Publisher：PERGAMON-ELSEVIER SCIENCE LTD

We have developed a new method for the direct aldol condensation of unactivated amides using 1,3,5-triazo-2,4,6-triphosphorine-2,2,4,4,6,6-hexachloride (TAPC)-based phosphorous/SO42- catalysis. The SO42- species in a reaction mixture enhances the reaction rate of the catalysis. In principle, no metal sources are required for the generation of the catalyst, and there is no requirement for the use of stoichiometric quantities of an acid or base. This catalyst system is operative under relatively acidic conditions. One major advantage of carrying out the reaction under acidic conditions is that both aldehydes and acetals are capable of undergoing carbon-carbon bond formation at the alpha-carbon of amide carbonyl groups through dehydration. (C) 2012 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2012.07.129

Web of Science

Cu-I/H-2/NaOH-Catalyzed Cross-Coupling of Two Different Alcohols for Carbon-Carbon Bond Formation: "Borrowing Hydrogen"? Invited Reviewed

Takashi Miura, Osamu Kose, Feng Li, Sun Kai, Susumu Saito

CHEMISTRY-A EUROPEAN JOURNAL Vol. 17 ( 40 ) page： 11146 - 11151 2011.9

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Papers - SAITO, Susumu