Faculty Profiles - HONDA, Hiroyuki

Papers - HONDA, Hiroyuki

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In Silico Screening of a Bile Acid Micelle Disruption Peptide for Oral Consumptions from Edible Peptide Database Reviewed

Kento Imai, Yuri Takeuchi, Kazunori Shimizu, Hiroyuki Honda

Foods Vol. 10 page： 2496 2021.10

Identification of barley-derived peptides with angiotensin converting enzyme inhibitory activity

Endo, K; Akiyama, H; Kano, K; Mishiro-Sato, E; Karashima, T; Kajiwara, Y; Takashita, H; Shimizu, K; Honda, H

INTERNATIONAL JOURNAL OF FOOD ENGINEERING Vol. 21 ( 2 ) page： 87 - 95 2025.3

Quercetin induces a slow myofiber phenotype in engineered human skeletal muscle tissues

Nagai, A; Kaneda, Y; Izumo, T; Nakao, Y; Honda, H; Shimizu, K

FASEB JOURNAL Vol. 38 ( 16 ) page： e70009 2024.8

Discovery of fibroblast growth factor 2-derived peptides for enhancing mice skeletal muscle satellite cell proliferation

Fujii, I; Kinoshita, R; Akiyama, H; Nakamura, A; Iwamori, K; Fukada, S; Honda, H; Shimizu, K

BIOTECHNOLOGY JOURNAL Vol. 19 ( 8 ) page： e2400278 2024.8

Separation and enrichment of multiple bile acid micelle-disrupting peptides by adsorption/desorption process with heat-treated porous silica gels

Iriyama, M; Hagawa, H; Shimizu, S; Akiyama, H; Shimizu, K; Honda, H

BIOCHEMICAL ENGINEERING JOURNAL Vol. 205 2024.5

Electrical pulse stimulation-induced tetanic exercise simulation increases the secretion of extracellular vesicles from C2C12 myotubes

Murata, A; Akiyama, H; Honda, H; Shimizu, K

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 672 page： 177 - 184 2023.9

l-Anserine Increases Muscle Differentiation and Muscle Contractility in Human Skeletal Muscle Cells

Nagai, A; Ida, M; Izumo, T; Nakai, M; Honda, H; Shimizu, K

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Vol. 71 ( 23 ) page： 8952 - 8958 2023.5

A Sulfur Containing Melanogenesis Substrate, N-Pr-4-S-CAP as a Potential Source for Selective Chemoimmunotherapy of Malignant Melanoma

Tamura, Y; Ito, A; Wakamatsu, K; Torigoe, T; Honda, H; Ito, S; Jimbow, K

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 24 ( 6 ) 2023.3

Alignment of Skeletal Muscle Cells Facilitates Acetylcholine Receptor Clustering and Neuromuscular Junction Formation with Co-Cultured Human iPSC-Derived Motor Neurons

Shimizu, K; Kassai, H; Kamei, Y; Yamamoto, K; Nagashima, T; Maekawa, T; Akiyama, H; Honda, H

CELLS Vol. 11 ( 23 ) 2022.12

Detection of protease digestion site using fluorescence labeled peptide array and construction of machine-learning prediction model Reviewed

Ryota Mizutani, Yoko Mori, Shodai Ogawa, Kaho Tazoe, Hirokazu Akiyama, Kazunori Shimizu, Hiroyuki Honda

Seibutsu-kogaku Kaishi Vol. 100 ( 10 ) page： 528 - 540 2022.11

Molecular Events in the Melanogenesis Cascade as Novel Melanoma-Targeted Small Molecules: Principle and Development

Wakamatsu, K; Ito, A; Tamura, Y; Hida, T; Kamiya, T; Torigoe, T; Honda, H; Ito, S; Jimbow, K

CANCERS Vol. 14 ( 22 ) 2022.11

Screening of anti-atrophic peptides by using photo-cleavable peptide array and 96-well scale contractile human skeletal muscle atrophy models

Yamamoto, K; Ohsumi, S; Nagashima, T; Akiyama, H; Honda, H; Shimizu, K

BIOTECHNOLOGY AND BIOENGINEERING Vol. 119 ( 8 ) page： 2196 - 2205 2022.8

Development of microfluidic chip for entrapping tobacco BY-2 cells Reviewed

Kazunori Shimizu, Yaichi Kawakatsu, Ken-ichi Kurotani, Masahiro Kikkawa,Ryo Tabata, Daisuke Kurihara, Hiroyuki Honda, Michitaka Notaguchi

PLOS ONE Vol. 17 ( 4 ) page： e0266982 2022.4

Selective concentration of antimicrobial peptides to heat-treated porous silica gel using adsorption/desorption

Hagawa Hitomi, Imai Kento, Gao Ziwei, Taniguchi Masayuki, Shimizu Kazunori, Honda Hiroyuki

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 133 ( 2 ) page： 161 - 167 2022.2

「ペプチドアレイ」を基盤とする低抗原性生理活性ペプチドの製造に関する研究 Reviewed

栗本昌樹、久保智里、越智浩、本多裕之、大河内美奈

生物工学会誌 Vol. 100 ( 2 ) page： 70 - 75 2022

Immunomodulation of Melanoma by Chemo-Thermo-Immunotherapy Using Conjugates of Melanogenesis Substrate NPrCAP and Magnetite Nanoparticles: A Review Reviewed

Yasuaki Tamura, Akira Ito, Kazumasa Wakamatsu, Takafumi Kamiya, Toshihiko Torigoe, Hiroyuki Honda, Toshiharu Yamashita, Hisashi Uhara, Shosuke Ito and Kowichi Jimbow

International Journal of Molecular Sciences Vol. 23 ( 12 ) page： 6457 2022

Analysis of Plasmodesmata Permeability using Cultured Tobacco BY-2 Cells Entrapped in Microfluidic Chips Reviewed

Ken-ichi Kurotani, Yaichi Kawakatsu, Masahiro Kikkawa, Ryo Tabata, Daisuke Kurihara, Hiroyuki Honda, Kazunori Shimizu, Michitaka Notaguchi

Journal of Plant Research Vol. 135 page： 693 - 701 2022

Molecular Events in the Melanogenesis Cascade as Novel Melanoma-Targeted Small Molecules: Principle and Development Reviewed

Kazumasa Wakamatsu, Akira Ito, Yasuaki Tamura, Tokimasa Hida, Takafumi Kamiya,Toshihiko Torigoe, Hiroyuki Honda, Shosuke Ito and Kowichi Jimbow

Cancers Vol. 14 page： 5588 2022

Agonist/Antagonist Activity of Oxytocin Variants Obtained from Free Cyclic Peptide Libraries Generated via Amino Acid Substitution

ACS OMEGA Vol. 6 ( 46 ) page： 31244 - 31252 2021.11

In Silico Screening of a Bile Acid Micelle Disruption Peptide for Oral Consumptions from Edible Peptide Database

Imai, K; Takeuchi, Y; Shimizu, K; Honda, H

FOODS Vol. 10 ( 10 ) 2021.10

Simple stain-free screening method for pectinolytic microorganisms under alkalophilic conditions

Ishihara, M; Kikkawa, M; Shimizu, K; Suzuki, H; Honda, H

BIOTECHNOLOGY LETTERS Vol. 43 ( 9 ) page： 1905 - 1911 2021.9

Machine learning screening of bile acid-binding peptides in a peptide database derived from food proteins

Imai Kento, Shimizu Kazunori, Honda Hiroyuki

SCIENTIFIC REPORTS Vol. 11 ( 1 ) page： 16123 2021.8

Effect of Magnetic Nanoparticle Internalization on Cell Density in Skeletal Muscle Tissue Reviewed

Yuji Kirihara, Hiromu Miyata, Zugui Peng, Kenta Shimba, Yoshitaka Miyamoto, Kazunori Shimizu, Hiroyuki Honda, Tohru Yagi

IEEJ Transactions on Electronics, Information and Systems Vol. 141 ( 7 ) page： 795 - 801 2021.7

Development of a human neuromuscular tissue-on-a-chip model on a 24-well-plate-format compartmentalized microfluidic device

Yamamoto, K; Yamaoka, N; Imaizumi, Y; Nagashima, T; Furutani, T; Ito, T; Okada, Y; Honda, H; Shimizu, K

LAB ON A CHIP Vol. 21 ( 10 ) page： 1897 - 1907 2021.5

Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution

Yoshioka, K; Yamashita, H; Shimizu, K; Shimomura, S; Shibata, T; Miyazaki, J; Honda, H

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 550 page： 177 - 183 2021.4

Screening of a novel free fatty acid receptor 1 (FFAR1) agonist peptide by phage display and machine learning based-amino acid substitution Reviewed

Keitaro Yoshioka, Haruki Yamashita, Kazunori Shimizu, Sayako Shimomura, Takahiro Shibata, Jun-ichi Miyazaki, Hiroyuki Honda

Biochemical and Biophysical Research Communications Vol. 550 page： 177 - 183 2021.2

Screening of FFAR1 activating peptide by molecular structure analysis Reviewed

Kagaku Kogaku Ronbunshu Vol. 47 ( 3 ) page： 64-68 2021.2

Heterologous production of new lasso peptide koreensin based on genome mining

Fuwa, H; Hemmi, H; Kaweewan, I; Kozaki, I; Honda, H; Kodani, S

JOURNAL OF ANTIBIOTICS Vol. 74 ( 1 ) page： 42 - 50 2021.1

Increasing the activity of cell adherent cyclic NGR peptides by optimizing the peptide length and amino acid character Reviewed

Kozaki Ikko, Suzuki Takehiro, You Sheng-Chao, Shimizu Kazunori, Honda Hiroyuki

JOURNAL OF PEPTIDE SCIENCE Vol. 27 ( 1 ) page： e3287 2021.1

Effect of Magnetic Nanoparticle Internalization on Cell Density in Skeletal Muscle Tissue Reviewed

Yuji Kirihara, Hiromu Miyata, Zugui Peng, Kenta Shimba, Yoshitaka Miyamoto, Kazunori Shimizu, Hiroyuki Honda, Tohru Yagi

IEEJ Transactions on Electronics, Information and Systems Vol. 141 ( 7 ) page： 795 - 801 2021

Screening of FFAR1-Activating Peptides by Molecular Structural Analysis

Yoshioka, K; Yamashita, H; Fujitani, M; Kato, R; Shimizu, K; Honda, H

KAGAKU KOGAKU RONBUNSHU Vol. 47 ( 3 ) page： 64 - 68 2021

Controlling distance, size and concentration of nanoconjugates for optimized LSPR based biosensors

Chowdhury, AD; Nasrin, F; Gangopadhyay, R; Ganganboina, AB; Takemura, K; Kozaki, I; Honda, H; Hara, T; Abe, F; Park, S; Suzuki, T; Park, EY

BIOSENSORS & BIOELECTRONICS Vol. 170 page： 112657 2020.12

Antidepressive effect of an inward rectifier K+ channel blocker peptide, tertiapin-RQ

Okada, M; Kozaki, I; Honda, H

PLOS ONE Vol. 15 ( 11 ) page： e0233815 2020.11

Machine Learning-Based Amino Acid Substitution of Short Peptides: Acquisition of Peptides with Enhanced Inhibitory Activities against alpha-Amylase and alpha-Glucosidase

Yamashita Haruki, Fujitani Masaya, Shimizu Kazunori, Kanie Kei, Kato Ryuji, Honda Hiroyuki

ACS BIOMATERIALS SCIENCE & ENGINEERING Vol. 6 ( 11 ) page： 6117 - 6125 2020.11

Bile acid micelle disruption activity of short-chain peptides from tryptic hydrolyzate of edible proteins Reviewed

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 130 ( 5 ) page： 514 - 519 2020.11

In Vitro Model of Human Skeletal Muscle Tissues with Contractility Fabricated by Immortalized Human Myogenic Cells

Nagashima, T; Hadiwidjaja, S; Ohsumi, S; Murata, A; Hisada, T; Kato, R; Okada, Y; Honda, H; Shimizu, K

ADVANCED BIOSYSTEMS Vol. 4 ( 11 ) page： e2000121 2020.11

Effect of cell-extracellular matrix interaction on myogenic characteristics and artificial skeletal muscle tissue

Ding, R; Horie, M; Nagasaka, S; Ohsumi, S; Shimizu, K; Honda, H; Nagamori, E; Fujita, H; Kawamoto, T

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 130 ( 1 ) page： 98 - 105 2020.7

Fluorometric virus detection platform using quantum dots-gold nanocomposites optimizing the linker length variation

Nasrin, F; Chowdhury, AD; Takemura, K; Kozaki, I; Honda, H; Adegoke, O; Park, EY

ANALYTICA CHIMICA ACTA Vol. 1109 page： 148 - 157 2020.5

Fabrication of contractile skeletal muscle tissues using directly converted myoblasts from human fibroblasts.

Shimizu K, Ohsumi S, Kishida T, Mazda O, Honda H

Journal of bioscience and bioengineering Vol. 129 ( 5 ) page： 632 - 637 2020.5

Disulfide linked hetero dimeric peptide arrays for screening functional peptides inside cells.

Kozaki I, Shimizu K, Honda H

Journal of bioscience and bioengineering Vol. 129 ( 5 ) page： 613 - 618 2020.5

Effectiveness of Lifestyle Intervention Using the Internet of Things System for Individuals with Early Type 2 Diabetes Mellitus

Kato Sawako, Ando Masahiko, Honda Hiroyuki, Yoshida Yasuko, Imaizumi Takahiro, Yamamoto Naoki, Maruyama Shoichi

INTERNAL MEDICINE Vol. 59 ( 1 ) page： 45 - 53 2020

Increasing the activity of cell adherent cyclic NGR peptides by optimizing the peptide length and amino acid character Reviewed

Ikko Kozaki, Takehiro Suzuki, You Sheng-Chao, Kazunori Shimizu, Hiroyuki Hond

Journal of Peptide Science Vol. 27 ( 1 ) page： e3287 2020

Fluorometric virus detection platform using quantum dots-gold nanocomposites optimizing the linker length variation Reviewed

Fahmida Nasrin, Ankan Dutta Chowdhury, Kenshin Takemura, Ikko Kozaki, Hiroyuki Honda, Oluwasesan Adegoke, Enoch Y. Park

Analytica Chimica Acta Vol. 1109 page： 148-157 2020

Effect of cell-extracellular matrix interaction on myogenic characteristics and artificial skeletal muscle tissue Reviewed

Ran Ding, Masanobu Horie, Sumire Nagasaka, Saki Ohsumi, Kazunori Shimizu, Hiroyuki Honda, Eiji Nagamori, Hideaki Fujita, Takuo Kawamoto

Journal of Bioscience and Bioengineering Vol. 130 ( 1 ) page： 98-105 2020

Bile acid micelle disruption activity of short-chain peptides from tryptic hydrolysate of edible proteins Reviewed

Masako Ito, Kazunori Shimizu, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 130 ( 5 ) page： 514-519 2020

Heterologous production of new lasso peptide koreensin based on genome mining Reviewed

Haruki Yamashita, Masaya Fujitani, Kazunori Shimizu, Kei Kanie, Ryuji Kato, Hiroyuki Honda

The Journal of Antibiotics 2020

Increasing the activity of cell adherent cyclic NGR peptides by optimizing the peptide length and amino acid character Reviewed

Ikko Kozaki, Takehiro Suzuki, You Sheng-Chao, Kazunori Shimizu, Hiroyuki Honda

Journal of Peptide Science Vol. 27 ( 1 ) page： e3287 2020

Machine learning-based amino acid substitution of short peptides: Acquisition of peptides with enhanced inhibitory activities against α-amylase and α-glucosidase Reviewed

Haruki Yamashita, Masaya Fujitani, Kazunori Shimizu, Kei Kanie, Ryuji Kato, Hiroyuki Honda

ACS Biomaterials Science & Engineering 2020

Controlling distance, size and concentration of nanoconjugates for optimized LSPR based biosensors Reviewed

Ankan Dutta Chowdhury, Fahmida Nasrin, Rupali Gangopadhyay, Akhilesh Babu Ganganboina, Kenshin Takemura, Ikko Kozaki, Hiroyuki Honda, Toshimi Hara, Fuyuki Abe, Tetsuro Suzuki, Enoch Y. Park

Biosensors and Bioelectronics Vol. 170 page： 112657 2020

In Vitro Model of Human Skeletal Muscle Tissues with Contractility Fabricated by Immortalized Human Myogenic Cells Reviewed

Kazunori Shimizu, Takunori Nagashima, Stacy Hariwijawa, Saki Ohsumi, Akari Murata, Yohei Okada, Hiroyuki Honda

Advanced Biosystems 2020

Antidepressive effect of an inward rectifier K+ channel blocker peptide, tertiapin-RQ Reviewed

Masayoshi Okada, Ikko Kozaki, Hiroyuki Honda

PLoS ONE Vol. 15 ( 11 ) page： e023815 2020

Pep-MS assay: Protease hydrolysis assay system using photo-cleavable peptide array and mass spectrometer

Kurimoto Masaki, Shimizu Kazunori, Ochi Hiroshi, Abe Fumiaki, Honda Hiroyuki

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 128 ( 2 ) page： 156 - 161 2019.8

Predictive selection and evaluation of appropriate functional peptides for intestinal delivery with a porous silica gel

Imai Kento, Shimizu Kazunori, Honda Hiroyuki

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 128 ( 1 ) page： 44 - 49 2019.7

Open-Chamber Co-Culture Microdevices for Single-Cell Analysis of Skeletal Muscle Myotubes and Motor Neurons with Neuromuscular Junctions

Yamaoka Nao, Shimizu Kazunori, Imaizumi Yu, Ito Takuji, Okada Yohei, Honda Hiroyuki

BIOCHIP JOURNAL Vol. 13 ( 2 ) page： 127 - 132 2019.6

Identification of an early cell fate regulator by detecting dynamics in transcriptional heterogeneity and co-regulation during astrocyte differentiation

Ando Tatsuya, Kato Ryuji, Honda Hiroyuki

NPJ SYSTEMS BIOLOGY AND APPLICATIONS Vol. 5 page： 18 2019.5

Searching for high-binding peptides to bile acid for inhibition of intestinal cholesterol absorption using principal component analysis.

Ito M, Shimizu K, Honda H

Journal of bioscience and bioengineering Vol. 127 ( 3 ) page： 366 - 371 2019.3

Selective Elimination of Bitter Peptides by Adsorption to Heat-treated Porous Silica Gel

Imai Kento, Ikeda Aya, Shimizu Kazunori, Honda Hiroyuki

FOOD SCIENCE AND TECHNOLOGY RESEARCH Vol. 25 ( 2 ) page： 179 - 186 2019.3

In-process evaluation of culture errors using morphology-based image analysis

Imai Yuta, Yoshida Kei, Matsumoto Megumi, Okada Mai, Kanie Kei, Shimizu Kazunori, Honda Hiroyuki, Kato Ryuji

REGENERATIVE THERAPY Vol. 9 page： 15 - 23 2018.12

Genomic analysis of a Streptomyces tsukubaensis mutant with reduced FR900525 production isolated by selection for S-(2-aminoethyl) L-cysteine resistance

Shimizu Shiho, Futase Ayako, Yokoyama Tatsuya, Honda Hiroyuki

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 126 ( 5 ) page： 580 - 585 2018.11

Selective Elimination of Human Induced Pluripotent Stem Cells Using Medium with High Concentration of L-Alanine

Nagashima Takunori, Shimizu Kazunori, Matsumoto Ryo, Honda Hiroyuki

SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 12427 2018.8

Interaction between porous silica gel microcarriers and peptides for oral administration of functional peptides

Imai Kento, Shimizu Kazunori, Kamimura Mitsuhiro, Honda Hiroyuki

SCIENTIFIC REPORTS Vol. 8 ( 1 ) page： 10971 2018.7

Mutations responsible for alcohol tolerance in the mutant of Synechococcus elongatus PCC 7942 (SY1043) obtained by single-cell screening system.

Hirokawa Y, Kanesaki Y, Arai S, Saruta F, Hayashihara K, Murakami A, Shimizu K, Honda H, Yoshikawa H, Hanai T

Journal of bioscience and bioengineering Vol. 125 ( 5 ) page： 572 - 577 2018.5

Genomic analysis of a Streptomyces tsukubaensis mutant with reduced FR900525 production isolated by selection for S-(2-aminoethyl) L-cysteine resistance, Reviewed

Shiho Shimizu, Futase Ayako, Tatsuya Yokoyama, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 126 ( 5 ) page： 580-585 2018.5

Lifestyle intervention using Internet of Things (IoT) for the elderly: A study protocol for a randomized control trial (the BEST-LIFE study)

Kato Sawako, Ando Masahiko, Kondo Takaaki, Yoshida Yasuko, Honda Hiroyuki, Maruyama Shoichi

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 2 ) page： 175 - 182 2018.5

Effect of dietary energy and polymorphisms in BRAP and GHRL on obesity and metabolic traits.

Imaizumi T, Ando M, Nakatochi M, Yasuda Y, Honda H, Kuwatsuka Y, Kato S, Kondo T, Iwata M, Nakashima T, Yasui H, Takamatsu H, Okajima H, Yoshida Y, Maruyama S

Obesity research & clinical practice Vol. 12 ( 1S1 ) page： 39-48 2018.1

Effective screening for hypolipidemic bile acid-binding peptides by hierarchical clustering-based catalog array. Journal of Bioscience Reviewed

Ryuji Kato, Kei Kanie, Chiaki Kaga, Mina Okochi, Satoshi Nagaoka, Hiroyuki Honda

Biotechnology and Applied Biochemistry Vol. 1 ( 1 ) page： 1001 2018

Screening of peptides associated with adhesion and aggregation of Lactobacillus rhamnosus GG in vitro

Okochi Mina, Sugita Tomoya, Asai Yuji, Tanaka Masayoshi, Honda Hiroyuki

BIOCHEMICAL ENGINEERING JOURNAL Vol. 128 page： 178 - 185 2017.12

Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers

Kubo Yoko, Imaizumi Takahiro, Ando Masahiko, Nakatochi Masahiro, Yasuda Yoshinari, Honda Hiroyuki, Kuwatsuka Yachiyo, Kato Sawako, Kikuchi Kyoko, Kondo Takaaki, Iwata Masamitsu, Nakashima Toru, Yasui Hiroshi, Takamatsu Hideki, Okajima Hiroshi, Yoshida Yasuko, Maruyama Shoichi

PLOS ONE Vol. 12 ( 10 ) page： e0185476 2017.10

Morphology-based non-invasive quantitative prediction of the differentiation status of neural stem cells

Fujitani Masaya, Huddin Noor Safika, Kawai Shun, Kanie Kei, Kiyota Yasujiro, Shimizu Kazunori, Honda Hiroyuki, Kato Ryuji

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 124 ( 3 ) page： 351 - 358 2017.9

Randomized controlled trial for assessment of Internet of Things system to guide intensive glucose control in diabetes outpatients: Nagoya Health Navigator Study protocol

Onoue Takeshi, Goto Motomitsu, Kobayashi Tomoko, Tominaga Takashi, Ando Masahiko, Honda Hiroyuki, Yoshida Yasuko, Tosaki Takahiro, Yokoi Hisashi, Kato Sawako, Maruyama Shoichi, Arima Hiroshi

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 79 ( 3 ) page： 323 - 329 2017.8

Alcohol-tolerant mutants of cyanobacterium Synechococcus elongatus PCC 7942 obtained by single-cell mutant screening system

Arai Sayuri, Hayashihara Kayoko, Kanamoto Yuki, Shimizu Kazunori, Hirokawa Yasutaka, Hanai Taizo, Murakami Akio, Honda Hiroyuki

BIOTECHNOLOGY AND BIOENGINEERING Vol. 114 ( 8 ) page： 1771 - 1778 2017.8

Effective modification of cell death-inducing intracellular peptides by means of a photo-cleavable peptide array-based screening system

Kozaki Ikko, Shimizu Kazunori, Honda Hiroyuki

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 124 ( 2 ) page： 209 - 214 2017.8

Detection of Her2-overexpressing cancer cells using keyhole shaped chamber array employing a magnetic droplet-handling system

Okochi Mina, Koike Shinji, Tanaka Masayoshi, Honda Hiroyuki

BIOSENSORS & BIOELECTRONICS Vol. 93 page： 32 - 39 2017.7

Three-Dimensional Culture Model of Skeletal Muscle Tissue with Atrophy Induced by Dexamethasone.

Shimizu K, Genma R, Gotou Y, Nagasaka S, Honda H

Bioengineering (Basel, Switzerland) Vol. 4 ( 2 ) 2017.6

Reduction of FR900525 using an S-(2-aminoethyl) L-cysteine-resistant mutant

Shimizu Shiho, Futase Ayako, Yokoyama Tatsuya, Ueda Satoshi, Honda Hiroyuki

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 123 ( 6 ) page： 685-691 2017.6

Visualization of morphological categories of colonies for monitoring of effect on induced pluripotent stem cell culture status

Nagasaka Risako, Matsumoto Megumi, Okada Mai, Sasaki Hiroto, Kanie Kei, Kii Hiroaki, Uozumi Takayuki, Kiyota Yasujiro, Honda Hiroyuki, Kato Ryuji

REGENERATIVE THERAPY Vol. 6 page： 41 - 51 2017.6

Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers

Imaizumi Takahiro, Ando Masahiko, Nakatochi Masahiro, Maruyama Shoichi, Yasuda Yoshinari, Honda Hiroyuki, Kuwatsuka Yachiyo, Kato Sawako, Kondo Takaaki, Iwata Masamitsu, Nakashima Toru, Yasui Hiroshi, Takamatsu Hideki, Okajima Hiroshi, Yoshida Yasuko, Matsuo Seiichi

CLINICAL AND EXPERIMENTAL NEPHROLOGY Vol. 21 ( 3 ) page： 457-464 2017.6

Image-based cell quality evaluation to detect irregularities under same culture process of human induced pluripotent stem cells

Nagasaka Risako, Gotou Yuto, Yoshida Kei, Kanie Kei, Shimizu Kazunori, Honda Hiroyuki, Kato Ryuji

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 123 ( 5 ) page： 642-650 2017.5

Comparison of non-destructive evaluation methods for iPS cellular status monitoring

Nagasaka Risako, Gotou Yuto, Yoshida Kei, Kanie Kei, Shimizu Kazunori, Honda Hiroyuki, Kato Ryuji

JOURNAL OF PHARMACOLOGICAL SCIENCES Vol. 133 ( 3 ) page： S247 - S247 2017.3

Exploring high-affinity binding properties of octamer peptides by principal component analysis of tetramer peptides

Kume Akiko, Kawai Shun, Kato Ryuji, Iwata Shinmei, Shimizu Kazunori, Honda Hiroyuki

JOURNAL OF BIOSCIENCE AND BIOENGINEERING Vol. 123 ( 2 ) page： 230-238 2017.2

[Screening and design of short length functional peptide by peptide array].

Honda H

Seikagaku. The Journal of Japanese Biochemical Society Vol. 89 ( 1 ) page： 15-20 2017.2

; Reduction of FR900525 using an S-(2-aminoethyl) l-cysteine-resistant mutant Reviewed

Shiho Shimizu, , Ayako Futase, Tatsuya Yokoyama, Satoshi Ueda, Hiroyuki Honda

Journal of Bioscience and Bioengineering 2017

Detection of Her2-overexpressing cancer cells using keyhole shaped chamber array employing a magnetic droplet-handling system Reviewed

Mina Okochi, Shinji Koike, Masayoshi Tanaka, Hiroyuki Honda

Biosensors and Bioelectronics Vol. 93 page： 32-39 2017

Exploring high-affinity binding properties of octamer peptides by principal component analysis of tetramer peptides Reviewed

Akiko Kume, Shun Kawai, Ryuji Kato, Shinmei Iwata, Kazunori Shimizu, and Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 123 ( 2 ) page： 230-238 2017

Image-based cell quality evaluation to detect irregularities under same culture process of human induced pluripotent stem cells Reviewed

Risako Nagasaka; Yuto Gotou; Kei Yoshida; Kei Kanie, Kazunori Shimizu, Hiroyuki Honda, Ryuji Kato

Journal of Bioscience and Bioengineering Vol. 20170000 2017

Morphological Evaluation of Nonlabeled Cells to Detect Stimulation of Nerve Growth Factor Expression by Lyconadin B Reviewed

Shun Kawai, Hiroto Sasaki, Norihiro Okada, Kei Kanie, Satoshi Yokoshima, Tohru Fukuyama, Hiroyuki Honda, and Ryuji Kato

J Biomol Screen Vol. Ａｐｒ ( 28 ) 2016.4

Tobias Opthof, Marcel AG van der Heyden, Itsuo Kodama, Jong-Kook Lee: A new in vitro co-culture model using magnetic force-based nanotechnology Reviewed

Hiroki Takanari, Keiko Miwa, XianMing Fu, Junichi Nakai, Akira Ito, Kousuke Ino, Hiroyuki Honda, Wataru Tonomura, Satoshi Konishi

Journal of Cellular Physiology Vol. Ｆｅｂ ( 12 ) 2016.2

Development of a tactical screening method to investigate the characteristics of functional peptides Reviewed

Akiko Kume, Mina Okochi, Kazunori Shimizu, Yasuko Yoshida, and Hiroyuki Honda

Biotechnology and Bioprocess Engineering ( 21 ) page： 119-127 2016

A Single Cell Culture System of Cyanobacteria Using Lectin-Conjugated Magnetite Nanoparticles and Magnetic Force Reviewed

Sayuri Arai, Mina Okochi, Kazunori Shimizu, Taizo Hanai, Hiroyuki Honda

Biotechnology and Bioengineering ( 113 ) page： 112-119 2016

Comparisons of cell culture medium using distribution of morphological features in microdevice Reviewed

Hiroto Sasaki, Junko Enomoto, Yurika Ikeda, Hiroyuki Honda, Junji Fukuda, Ryuji Kato

Journal of Bioscience and Bioengineering ( 121 ) page： 117-123 2016

Rapid colorimetric antibody detection using a dual-function peptide probe for silver nanoparticle aggregation and antibody recognition Reviewed

Mina Okochi, Tomohiro Kamiya, Takeshi Omasa, Masayoshi Tanaka, Hiroyuki Honda

Analytical Sciences ( 32 ) page： 93-97 2016

Focused screening of ECM-selective adhesion peptides on cellulose-bound peptide microarrays Reviewed

Kei Kanie, Yuto Kondo, Junk Owaki, Yurika Ikeda, Yuji Narita, Ryuji Kato, Hiroyuki Honda

Bioengineering Vol. 3 page： 31 2016

Ex vivo culture of circulating tumor cells using magnetic force-based coculture on a fibroblast feeder layer Reviewed

Shuhei Yamamoto, Kazunori Shimizu, Jiahui Fei, Hiroji Iwata, Mina Okochi, Hayao Nakanishi and Hiroyuki Honda

Biotechnology Journal Vol. 11 ( 11 ) page： 1433-1442 2016

Parametric analysis of colony morphology of non-labelled live human pluripotent stem cells for cell quality control Reviewed

Ryuji Kato, Megumi Matsumoto, Hiroto Sasaki, Risako Joto, Mai Okada, Yurika Ikeda, Kei Kanie, Mika Suga, Masaki Kinehara, Kana Yanagihara, Yu-Jung Liu, Kozue Uchio-Yamada, Takayuki Fukuda, Hiroaki Kii, Takayuki Uozumi, Hiroyuki Honda, Yasujiro Kiyota, and Miho Furue

Scientific Reports Vol. 6 page： 34009 2016

Plasma-Activated Medium Selectively Eliminates Undifferentiated Human Induced Pluripotent Stem Cell

Ryo Matsumoto, Kazunori Shimizu, Takunori Nagashima, Hiromasa Tanaka, Masaaki Mizuno, Fumitaka Kikkawa, Masaru Hori, Hiroyuki Honda

Regenerative Therapy Vol. 5 page： 55-63 2016

Screening of Osteogenic-Enhancing Short Peptides from BMPs for Biomimetic Material Applications Reviewed

Kei Kanie, Rio Kurimoto, Jing Tian, Katsumi Ebisawa, Yuji Narita, Hiroyuki Honda and Ryuji Kato

Materials Vol. 9 page： 730 2016

Association of interactions between dietary salt consumption and hypertension- susceptibility genetic polymorphisms with blood pressure among Japanese male workers Reviewed

Takahiro Imaizumi, Masahiko Ando, Masahiro Nakatochi2, Shoichi Maruyama, Yoshinari Yasuda, Hiroyuki Honda, Yachiyo Kuwatsuka, Sawako Kato, Takaaki Kondo, Masamitsu Iwata, Toru Nakashima, Hiroshi Yasui, Hideki Takamatsu, Hiroshi Okajima, Yasuko Yoshida, Seiichi Matsuo

Clinical and Experimental Nephrology 2016

Effect of dietary energy andpolymorphisms in BRAP and GHRL onobesity and metabolic traits Reviewed

Takahiro Imaizumi, Masahiko Ando, Masahiro Nakatochi, Yoshinari Yasuda, Hiroyuki Honda, Yachiyo Kuwatsuka, Sawako Kato, Takaaki Kondo, Masamitsu Iwata, Toru Nakashima, Hiroshi Yasui,Hideki Takamatsu, Hiroshi Okajima, Yasuko Yoshida,Shoichi Maruyama

Obesity Research & Clinical Practice 2016

Identification of an interaction between VWF rs7965413 and platelet count as a novel risk marker for metabolic syndrome: an extensive search of candidate polymorphisms in a case-control study Reviewed

Masahiro Nakatochi, Yasunori Ushida, Yoshinari Yasuda, Yasuko Yoshida, Shun Kawai, Ryuji Kato, Toru Nakashima, Masamitsu Iwata, Yachiyo Kuwatsuka, Masahiko Ando, Nobuyuki Hamajima, Takaaki Kondo, Hiroaki Oda, Mutsuharu Hayashi, Sawako Kato, Makoto Yamaguchi, Shoichi Maruyama, Seiichi Matsuo, and Hiroyuki Honda

PLOS ONE ( Feburary 3 ) 2015

Effects of the properties of short peptides conjugated with cell-penetrating peptides on their internalization into cells Reviewed

Ryo Matumoto,Mina Okochi,Kazunori Shimizu,Kei Kanie,Ryuji Kato and Hiroyuki Honda

SCIENCE REPORTS 2015

Three-dimensional magnetic cell array for evaluation of anti-proliferative effects of chemo-thermo treatment on cancer spheroids Reviewed

Shuhei Yamamoto, Mina Okochi, Kowichi Jimbow, and Hiroyuki Honda

Biotechnology and Bioprocess Engineering ( 20 ) page： 488-497 2015

Differential variability and correlation of gene expression identifies key genes involved in neuronal differentiation Reviewed

Tatsuya Ando, Ryuji Kato, Hiroyuki Honda

BMC Systems Biology Vol. 9 ( 82 ) 2015

In vivo heat-stimulus-triggered osteogenesis Reviewed

Kunihiro Ikuta, Hiroshi Urakawa, Eiji Kozawa, Shunsuke Hamada, Takehiro Ota, Ryuji Kato, Hiroyuki Honda

International Journal of Hyperthermia Vol. 31 ( 1 ) page： 58-66 2015

Design of dual functional peptide probe both as binder to angiotensin II and inducer of silver nanoparticle aggregation for label-free colorimetric assay Reviewed

Mina Okochi, Masashi Kuboyama, Masayoshi Tanaka and Hiroyuki Honda

TALANTA ( 142 ) page： 235-239 2015

Efficient capturing of circulating tumor cells using a magnetic capture column and a size-selective filter Reviewed

Shuhei Yamamoto, Jiahui Fei, Mina Okochi, Kazunori Shimizu, Akiko Yusa, Naoto Kondo, Hiroji Iwata, Hayao Nakanishi, and Hiroyuki Honda

Bioprocess and Biosystems Engineering ( 38 ) page： 1693-1704 2015

Development of a tactical screening method to investigate the characteristics of functional peptides Reviewed

Tatsuya Ando, Ryuji Kato, Hiroyuki Honda

BMC Systems Biology Vol. 9 ( 82 ) 2015

Characterization of Time-Course Morphological Features for Efficient Prediction of Osteogenic Potential in Human Mesenchymal Stem Cells Reviewed

Fumiko Matsuoka, Ichiro Takeuchi, Hideki Agata, Hideaki Kagami, Hirofumi Shiono, Yasujiro Kiyota, Hiroyuki Honda, Ryuji Kato

Biotechnology and Bioengineering 2014

Label-Free Morphology-Based Prediction of Multiple D ifferentiation Potentials of Human Mesenchymal StemCells for Early Evaluation of Intact Cells Reviewed

Hiroto Sasaki, Ichiro Takeuchi, Mai Okada, Rumi Sawada, Kei Kanie1, Yasujiro Kiyota,Hiroyuki Honda, Ryuji Kato

PLOS ONE Vol. 9 ( 4 ) page： e93952 2014

Degranulation of basophilic leukemia cells on branched-chain peptide array with an ova-dnp double epitope Reviewed

Hisayuki Sugiura, Noriyasu Okazaki, Toshimi Sugiura, Hiroyuki Honda, Mina Okochi

Biochemical Engineering Journal Vol. 87 page： 8–14 2014

Design of Quenching Peptide Probes Incorporating Tryptophan for Rapid IgG Detection Reviewed

Tomoya Sugita, Mina Okochi, and Hiroyuki Honda

Chemistry Letters Vol. 43 ( 4 ) page： 550–552 2014

Development of a New Rapid Isolation Device for Circulating Tumor Cells (CTCs) Using 3D Palladium Filter and Its Application for Genetic Analysis

Akiko Yusa, Makoto Toneri, Taisuke Masuda, Seiji Ito, Shuhei Yamamoto, Mina Okochi, Naoto Kondo, Hiroji Iwata, Yasushi Yatabe, Yoshiyuki Ichinosawa, Seichin Kinuta, Eisaku Kondo, Hiroyuki Honda, Fumihito Arai, Hayao Nakanishi

PLOS ONE Vol. 9 ( 2 ) page： e88821 2014

In vivo heat-stimulus-triggered osteogenesis Reviewed

Kunihiro Ikuta, Hiroshi Urakawa, Eiji Kozawa, Shunsuke Hamada, Takehiro Ota, Ryuji Kato, Hiroyuki Honda, Takeshi Kobayashi, Naoki Ishiguro, and Yoshihiro Nishida

International Journal of Hyperthermia ( Dec 19 ) page： 1-9 2014

Micro-compartmentalized cultivation of cyanobacteria for mutant screening using glass slides with highly water-repellent mark Reviewed

Sayuri Arai, Mina Okochi, Taizo Hanai, Hiroyuki Honda

Biotechnology Reports Vol. 4 page： 151-155 2014

Effect of Vascular Formed Endothelial Cell Network on the Invasive Capacity of Melanoma Using the In Vitro 3D Co-Culture Patterning Model Reviewed

Shuhei Yamamoto, Michael Masakuni Hotta, Mina Okochi, Hiroyuki Honda

PLOS ONE Vol. 9 ( 7 ) page： e103502 2014

Cell Behavior Observation and Gene Expression Analysis of Melanoma Associated with Stromal Fibroblasts in a Three-Dimensional Magnetic Cell Culture Array Reviewed

Mina Okochi, Taku Matsumura, Shuhei Yamamoto, Eiichi Nakayama, Kowichi Jimbow, Hiroyuki Honda

Biotechnology Progress Vol. 29 ( 1 ) page： 135-142 2013

Comprehensive Combination Analysis for Screening of Significant Peptide Epitopes Using a Slide Glass Type-Exclusive Peptide Array from Milk Protein Reviewed

Vol. 39 ( 1 ) page： 40-45 2013

Combinational risk factors of metabolic syndrome from health check-up data identified by Fuzzy neural network Reviewed

Yasunori Ushida, Ryuji Kato, Kosuke Niwa, Daisuke Tanimura, Hideo Izawa, Kenji Yasui, Tomokazu Takase, Yasuko Yoshida, Mitsuo Kawase, Tsutomu Yoshida, Toyoaki Murohara, Hiroyuki Honda

BMC Medical Informatics and Decision Making Vol. 12 ( 80 ) page： doi:10.1186/1472-6947-12-80. 7. 2013

iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis Reviewed

Tetsutaro Kito, Rei Shibata, Masakazu Ishii, Hirohiko Suzuki, Tatsuhito Himeno, Yoshiyuki Kataoka, Yumiko Yamamura, Takashi Yamamoto, Naomi Nishio, Sachiko Ito, Yasushi Numaguchi, Tohru Tanigawa, Jun K Yamashita, Noriyuki Ouchi, Hiroyuki Honda, Kenichi Isobe and Toyoaki Murohara

Scientific Reports Vol. 3 page： 1418 2013

Image-Based Cell Quality Assessment: Modeling of Cell Morphology and Quality for Clinical Cell Therapy Reviewed

Hiroto Sasaki, Fumiko Matsuoka, Wakana Yamamoto, Kenji Kojima, Hiroyuki Honda and Ryuji Kato

Tissue Engineering and Biomaterials Vol. 10 page： 207-226 2013

Morphology-Based Prediction of Osteogenic Differentiation Potential of Human Mesenchymal Stem Cells. Reviewed

Fumiko Matsuoka, Ichiro Takeuchi, Hideki Agata, Hideaki Kagami, Hirofumi Shiono, Yasujiro Kiyota, Hiroyuki Honda, Ryuji Kato

PLoS ONE Vol. 8 ( 2 ) page： e55082 2013

T-cell receptor repertoires of tumor-infiltrating lymphocytes after hyperthermia using functionalized magnetite nanoparticles. Reviewed

Ito A, Yamaguchi M, Okamoto N, Sanematsu Y, Kawabe Y, Wakamatsu K, Ito S, Honda H, Kobayashi T, Nakayama E, Tamura Y, Okura M, Yamashita T, Jimbow K, Kamihira M

Nanomedicine Vol. 8 ( 6 ) page： 891-902 2013

Melanoma-Targeted Chemothermotherapy and In Situ Peptide Immunotherapy through HSP Production by Using Melanogenesis Substrate, NPrCAP, and Magnetite Nanoparticles

Kowichi Jimbow, Yasue Ishii-Osai, Shosuke Ito, Yasuaki Tamura, Akira Ito, Akihiro Yoneta, Takafumi Kamiya, Toshiharu Yamashita, Hiroyuki Honda, Kazumasa Wakamatsu, Katsutoshi Murase, Satoshi Nohara, Eiichi Nakayama, Takeo Hasegawa, Itsuo Yamamoto, and Takeshi Kobayashi

Journal of Skin Cancer 2013

Droplet-based biochemical assay by magnetic wire manipulation between multiple droplets

Mitsuhiro Shikida, Tatsuaki Sugito, Mina Okochi, Hiroyuki Honda

Microsystem Technologies Vol. 20 page： 315-323 2013

Morphology-Based Prediction of Osteogenic Differentiation Potential of Human Mesenchymal Stem Cells Reviewed

Fumiko Matsuoka, Ichiro Takeuchi, Hideki Agata, Hideaki Kagami, Hirofumi Shiono, Yasujiro Kiyota, Hiroyuki Honda, Ryuji Kato

PLOS ONE Vol. 8 ( 2 ) page： e55082 2013

Detection of QT Prolongation Through Approximation of the T Wave on Gaussian Mixture Modeling Reviewed

Shin Hibino, Norihiro Ueda, Mitsuru Horiba, Kenji Yasui, Yuusuke Kagamihara, Shuji Funahashi, Kaichiro Kamiya, Hiroyuki Honda

Circulation Journal Vol. 77 page： 2728-2735 2013

Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: Potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses Reviewed

Hiro Takahashi, Robert Nakayama, Shuhei Hayashi, Takeshi Nemoto, Yasuyuki Murase, Koji Nomura, Teruyoshi Takahashi, Kenji Kubo, Shigetaka Marui, Koji Yasuhara, Tetsuro Nakamura, Takuya Sueo, Anna Takahashi, Kaname Tsutsumiuchi, Tsutomu Ohta, Akira Kawai, Shintaro Sugita, Shinjiro Yamamoto, Takeshi Kobayashi, Hiroyuki Honda, Teruhiko Yoshida, Tadashi Hasegawa

PLOS ONE Vol. 8 ( 10 ) page： e78250 2013

Screening of peptide ligands that bind to the Fc region of IgG using peptide array and its application to affinity purification of antibody. Reviewed

Tomoya Sugita, Makoto Katayama, Mina Okochi, Takamitsu Ichihara, Ryuji Kato, and Hiroyuki Honda

Biochemical Engineering Journal Vol. 79 page： 33-40 2013

Magnetic force-based cell patterning for evaluation of the effect of stromal fibroblasts on invasive capacity in 3D cultures. Reviewed

Mina Okochi, Taku Matsumura, and Hiroyuki Honda

Biosensors and Bioelectronics Vol. 40 page： 300-307 2013

Mechanism of putative neo-antigen formation from N-propionyl-4-Scysteaminylphenol,a tyrosinase substrate, in melanoma models Reviewed

Shosuke Ito, Akira Nishigaki, Yasue Ishii-Osai, Makoto Ojika, Kazumasa Wakamatsu,Toshiharu Yamashita, Yasuaki Tamura, Akira Ito, Hiroyuki Honda, Eiichi Nakayama, Kowichi Jimbow

Biochemical Pharmacology Vol. 84 page： 646-653 2012

Screening for silver nanoparticle-binding peptides by using a peptide array Reviewed

Masashi Kuboyama, Ryuji Kato, Mina Okochi, Hiroyuki Honda

Biochemical Engineering Journal Vol. 66 page： 73– 77 2012

N-propionyl-4-S-cysteaminylphenol induces apoptosis in B16F1 cells and mediates tumor-specific T-cell immune responses in a mouse melanoma model Reviewed

Yasue Ishii-Osai, Toshiharu Yamashita, Yasuaki Tamura, Noriyuki Sato, Akira Ito, Hiroyuki Honda, Kazumasa Wakamatsu, Shosuke Ito, Eiichi Nakayama, Masae Okura and Kowichi Jimbow

Journal of Dermatological Science Vol. 67 page： 51-60 2012

Screening of an α-Amylase Inhibitor Peptide by photolinker-Peptide Array Reviewed

Takashi Ochiai, Tomoya Sugita, Ryuji Kato, Mina Okochi, and Hiroyuki Honda

Bioscience, Biotechnology, and Biochemistry Vol. 76 ( 4 ) page： 819-824 2012

T-cell receptor repertoires of tumor-infiltrating lymphocytes after hyperthermia using functionalized magnetite nanoparticles

Akira Ito, Masaki Yamaguchi, Noriaki Okamoto, Yuji Sanematsu, Yoshiniri Kawabe, Kazumasa Wakamatsu, Shosuke Ito, Hiroyuki Honda, Takeshi Kobayashi, Eiichi Nakayama, Yasuaki Tamura, Masae Okura, Toshiharu Yamashita, Kowichi Jimbow and Masamichi Kamihira :

Nanomedicine 2012

Enhancement of the Activity of a Lactobacilli- Aggregating Peptide by Freezing Treatment

Yuji Asai, Tomoya Sugita, Ryuji Kato, Mina Okochi, Kyuya Nakagawa, and Hiroyuki Honda

Journal of Chemical Engineering Vol. 48 ( 5 ) page： 609-614 2012

Collagen type IV-specific tripeptides for selective adhesion of endothelial and smooth muscle cells Reviewed

Kei Kanie, Yuji Narita, Junki Owaki, Yingzi Zhao, Fumiaki Kuwabara, Makoto Satake, Susumu Honda, Hiroaki Kaneko, Tomohiko Yoshioka, Mina Okochi, Hiroyuki Honda,Ryuji Kato

Biotechnology and Bioengineering Vol. 109 ( 7 ) page： 1808-1816 2012

Gingival and dermal fibroblasts: Their similarities and differences revealed from gene expression Reviewed

Katsumi Ebisawa, Ryuji Kato, Mai Okada, Tomotaka Sugimura, Mazlyzam Abdul Latif, Yusuke Hori, Yuji Narita, Minoru Ueda, Hiroyuki Honda and Hideaki Kagami

Journal of Bioscience and Bioengineering Vol. 111 ( 3 ) page： 255-258 2011

Peptide Array-Based Peptide-Cell Interaction Analysis Reviewed

Ryuji Kato, Chiaki Kaga, Kei Kanie, Mitoshi Kunimatsu, Mina Okochi and Hiroyuki Honda

Mini-reviews in organic chemistry Vol. 8 ( 2 ) page： 171-177 2011

Personalized assessment of oxidative cellular damages associated with diabetes using the erythrocytes adhesion assay Reviewed

Mina Okochi, Yuki Sakai1 Yayoi Isaji, Hiroshi Nagasaki, Yoji Hamada, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 112 ( 6 ) page： 635-637 2011

Screening of IgG-Fc binding peptides from milk protein using slide glass type-exclusive peptide array Reviewed

Makoto KATAYAMA, Tomoya SUGITA, Ryuji KATO, Mina OKOCHI, Miyoko MATSUSHIMA, Tsutomu KAWABE, Tomokazu TAKASE, Yasuko YOSHIDA, Mitsuo KAWASE, Hiroyuki HONDA

Kagakukougaku Ronbunshu Vol. 37 page： 546-550 2011

Fabrication of a pen-shaped portable biochemical reaction system based on magnetic bead manipulatio

Mituhiro Shikita, Noriyuki Inagaku, Mina Okochi, Hiroyuki Honda, Kazuo Sato

Journal of Micromechanics and Microengineering Vol. 21 page： 7 2011

Droplet introduction into a pen-shaped portable reaction system by gravity and interfacial forces Reviewed

M. Shikita, N. Inagaki, M. Okochi, H. Honda, K. Sato

Micro & Nano Letters Vol. 6 ( 4 ) page： 253-256 2011

Screening of peptides with a high affinity to bile acids using peptide arrays and a computational analysis

Toshikazu Takeshita, Mina Okochi, Ryuji Kato, Chiaki Kaga, Yasuyuki Tomita, Satoshi Nagaoka, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 112 ( 1 ) page： 92-97 2011

mino acid sequence preferences to control cell-specific organization of endothelial cells, smooth muscle cells, and fibroblasts Reviewed

Kei Kanie, Ryuji Kato, Yingzi Zhao, Yuji Narita, Mina Okochi, Hiroyuki Honda

Journal of Peptide Science Vol. 17 ( 6 ) page： 479-486 2011

Peptide Array-Based Peptide-Cell Interaction Analysis Reviewed

Ryuji Kato, Chiaki Kaga, Kei Kanie, Mitoshi Kunimatsu, Mina Okochi and Hiroyuki Honda

Mini-reviews in organic chemistry Vol. 8 ( 2 ) page： 171-177 2011

Determination of combinational genetic and environmental risk factors of lifestyle-related disease by using health check-up data obtained from long-term follow-up Reviewed

Yasunori Ushida1, Ryuji Kato1, Daisuke Tanimura2, Hideo Izawa2, Kenji Yasui3,4, Tomokazu Takase5, Yasuko Yoshida, Mitsuo Kawase, Tsutomu Yoshida, Toyoaki Murohara, and Hiroyuki Honda

Seibutsu-kogaku Vol. 88 ( 11 ) page： 562-569 2010.4

Scale-up fermentation of echinocandin-type antibiotic FR901379 Reviewed

Munekazu Kanda, Eiji Yamamoto, Akihiro Hayashi, Tetsuya Yabutani, Michio Yamashita, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 109 ( 2 ) page： 138-144 2010

混合正規分布による心電図Ｔ波の近似とＱＴ間隔の自動計測への応用 Reviewed

日比野　新、中杤昌弘、上田典浩、堀場　充、安井健二、鏡原有祐、寺澤敏昭、神谷香一郎、児玉逸雄、松原充隆、本多裕之

生体医工学 Vol. 48 ( 4 ) page： 359-368 2010

Transfer of gene to human retinal pigment epithelial cells using magnetite cationic liposomes Reviewed

Yasuki Fujii, Shu Kachi, Akira Ito, Tamayo Kawasumi, Hiroyuki Honda, Hiroko Terasaki

British Journal of Ophthalmology Vol. 94 page： 1074-1077 2010

Melanoma-targeted chemo-thermo-immuno (CTI)-therapy using N-propionyl-4-S-cysteaminylphenol-magnetite nanoparticles elicits CTL response via heat shock protein-peptide complex release. Reviewed

Akiko Sato, Yasuaki Tamura, Noriyuki Sato, Toshiharu Yamashita, Tomoaki Takada, Makito Sato,Yasue Osai, Masae Okura, Ichiro Ono, Akira Ito, Hiroyuki Honda, Kazumasa Wakamatsu, Shosuke Ito and Kowichi Jimbow

Cancer Science Vol. 110 ( 9 ) page： 1939-1946 2010

Peptide Array-Based Characterization and Design of ZnO-High Affinity Peptides Reviewed

Mina Okochi, Tomoya Sugita, Seiji Furusawa, Mitsuo Umetsu, Tadafumi Adschiri, Hiroyuki Honda

Biotechnology and Bioengineering Vol. 106 ( 6 ) page： 845-851 2010

Construction of an Electrochemical Antibiofouling System for Plate Heat Exchangers Reviewed

Hitoshi Wake, Toshihiro Takimoto, Hirokazu Takayanagi, Kinichi Ozawa, Hideo Kadoi, Shigeki Mukai, Yoshinari Komura, Mina Okochi, Hiroyuki Honda and Tadashi Matsunaga

Journal of Chemical Engineering of Japan Vol. 43 ( 7 ) page： 608-611 2010

Practical cell labeling with magnetite cationic liposomes for cell manipulation Reviewed

Hiroshi Ito, Yurika Nonogaki, Ryuji Kato, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 110 ( 1 ) page： 124-129 2010

A compact, automated cell culture system for clinical scale cell expansion from primary tissues Reviewed

Ryuji Kato, Daisuke Iejima, Hideki Agata, Izumi Asahina, Kunihiko Okada, Minoru Ueda, Hiroyuki Honda, and Hideaki Kagami

Tissue Engineering Part C page： Ebub ahead print 2010

Directed evolution of angiotensin II-inhibiting peptides using a microbead display Reviewed

Rui Gan, Seiji Furuzawa, Takaaki Kojima, Kei Kanie, Ryuji Kato, Mina Okochi, Hiroyuki Honda, and Hideo Nakano

Journal of Bioscience and Bioengineering Vol. 109 ( 4 ) page： 411-417 2010

Screening of ZnO-high affinity peptide using spot-synthesized peptide arrays and computational analysis Reviewed

Mina Okochi, Masafumi Ogawa, Chiaki Kaga, Tomoya Sugita, Yasuyuki Tomita, Ryuji Kato, Hiroyuki Honda

Acta Biomaterialia Vol. 6 page： 2301-2306 2010

Fabrication process of carbon nanotube field effect transistors using atomic layer deposition passivation for biosensors. Reviewed

Yasuhiro Nakashima, Yutaka Ohno, Shigeru Kishimoto, Mina Okochi, Hiroyuki Honda, Takashi Mizutani

J. Nanosci. Nanotechnol. Vol. 10 page： 3805-3809 2010

: Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia: Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches Reviewed

Masashi Ikeda, Yasuyuki Tomita, Akihiro Mouri, Minori Koga, Tomo Ohkouchi, Reiji Yoshimura, Yoshio Yamanouchi, Yoko Kinoshita, Ryota Hashimoto, Hywel Williams, Masatoshi Takeda, Jun Nakamura, Toshitaka Nabeshima, Michael J. Owen, Michael C. O'Donovan, Hiroyuki Honda, Tadao Arinami, Norio Ozaki, Nakao Iwata

Biological Psychiatry Vol. 67 ( 3 ) page： 263-269 2010

Droplet-based gene expression analysis using a device with magnetic force-based-droplet-handling system Reviewed

Mina Okochi, Hiroyoshi Tsuchiya, Fumitaka Kumazawa, Mitsuhiro Shikida, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 109 ( 2 ) page： 193-197 2010

Magnetic manipulation device for the optimization of cell processing conditions Reviewed

Hiroshi Ito, Ryuji Kato, Kousuke Ino, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 109 ( 2 ) page： 182-188 2010

Approximation of ECG T Wave by Using Gaussian Mixtures and Automatic Measurement of QT Interval Reviewed

Shin Hibino, Masahiro Nakatochi, Norihiro Ueda, Mitsuru Horiba, Kenji Yasui, Yuusuke Kagamihara, Toshiaki Terazawa, Kaichiro Kamiya, Itsuo Kodama, Michitaka Matsubara, Hiroyuki Honda

Seitai-Ikougaku Vol. 48 ( 4 ) page： 359-368 2010

Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis s Reviewed

Masayuki Sano, Kazuhiko Aoyagi, Hiro Takahashi, Takashi Kawamura, Tomoko Mabuchi, Hiroyasu Igaki, Yuji Tachimori, Hoichi Kato, Atsushi Ochiai, Hiroyuki Honda, Yuji Nimura, Masato Nagino, Teruhiko Yoshida, Hiroki Sasak

International Journal of Oncology Vol. 36 page： 321-330 2010

Application of magnetic force-based cell patterning for controlling cell-cell interactions in angiogenesis Reviewed

Kosuke Ino, Mina Okochi, Hiroyuki Honda :

Biotechnology and Bioengineering Vol. 102 ( 3 ) page： 882-890 2009

*Peptide array-based analysis of the specific IgE and IgG4 in cow's milk allergens and its use in allergy evaluation Reviewed

Naoki Matsumoto, Mina Okochi, Miyoko Matsushima, Ryuji Kato, Tomokazu Takase, Yasuko Yoshida, Mitsuo Kawase, Ken-ichi Isobe, Tsutomu Kawabe, Hiroyuki Honda

Peptides Vol. 30 page： 1840-1847 2009

N-Propionyl-Cysteaminylphenol-Magnetite Conjugate (NPrCAP/M) Is a Nanoparticle for the Targeted Growth Suppression of Melanoma Cells Reviewed

Makito Sato, Toshihar Yamashita, Masae Ohkura, Yasue Osai, Akiko Sato, Tomoaki Takada, Hidenobu Matsusaka, Ichiro Ono, Yasuaki Tamura, Noriyuki Sato, Yasushi Sasaki, Akira Ito, Hiroyuki Hond, Kazumasa Wakamatsu, Shosuke Ito, Kowichi Jimbow

Journal of Investigative Dermatology Vol. 129 ( 9 ) page： 2233-2241 2009

短鎖機能性ペプチド探索：ペプチドインフォマティクス Invited Reviewed

本多裕之

生物工学会誌 Vol. 87 ( 6 ) page： 280-282 2009

Improvement of FR901379 production by mutant selecton and medium optimization Reviewed

Munekazu Kanda, Masaru Tsuboi, Kazutoshi Sakamoto, Shiho Shimizu, Michio Yamashita, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 107 ( 5 ) page： 530-534 2009

Screening of epithelial cell-adhesive peptides from fibronectin loop region and its cell specificity, Reviewed

Chiaki Kaga, Shigeyuki Nomura, Mina Okochi, Tomoko Nozu, Tomokazu Nagao, Atsushi Nagai, Toshinori Nakayama, Kazuo Suzuki, Hiroyuki Honda

Journal of Chemical Engineering of Japan Vol. 42 ( 4 ) page： 298-302 2009

Preparation of L929 cell array by magnetic pinholder device for single cell function analysis, Reviewed

Hironobu Koide, Yayoi Isaji, Mina Okochi, Hiroyuki Honda

Journal of Chemical Engineering of Japan Vol. 42 ( 4 ) page： 290-297 2009

Agitation of magnetic beads by multi-layered flat coils Reviewed

Mitsuhiro Shikida, Motoki Koyama, Nobuhiro Nagao, Rentaro Imai, Hiroyuki Honda, Mina Okochi, Hiroyoshi Tsuchiya, Kazuo Sato

Sensor and Actuator B: Chemical Vol. 137 page： 774-780 2009

残存脳腫瘍に対する磁気センサを用いた新しい腫瘍検出技術の開発（第一報）：マグネタイトカチオニックリポソーム投与の最適化と安全性, Reviewed

梶田泰一、本多裕之、内山　剛、加藤竜司、林　雄一郎、竹林成典、夏目敦至、水野正明、若林俊彦、吉田　純：

生体医工学 Vol. 47 ( 1 ) page： 99-104 2009

Drastic change in cell surface hydrophobicity of a new bacterial strain, Pseudomonas sp. TIS1-127, induced by growth temperature and its effects on the toluene-conversion rate Reviewed

Katsutoshi Hori, Naoto Hiramatsu, Mari Nannbu, Kei Kanie, Mina Okochi, Hiroyuki Honda, Hisami Watanabe

Journal of Bioscience and Bioengineering Vol. 107 ( 3 ) page： 250-255 2009

Development of peptide arrays for detection of IgE-binding epitopes in cow's milk allergens Reviewed

Naoki Matsumoto, Mina Okochi, Miyoko Matsushima, Akiko Ogawa, Tomokazu Takase, Yasuko Yoshida, Mitsuo Kawase, Ken-ichi Isobe, Tsutomu Kawabe, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 107 ( 3 ) page： 324-330 2009

*Three-dimensional cell culture array using magnetic force-based cell patterning for analysis of invasive capacity of BALB/3T3/v-src Reviewed

Mina Okochi, Sho Takano, Yayoi Isaji, Takeshi Senga, Michinari Hamaguchi, Hiroyuki Honda

Lab on a Chip Vol. 9 page： 3378-3384 2009

Magnetic force-based lab-on-a-chip for single cell analysis in a droplet Reviewed

Mina Okochi, Hiroyoshi Tsuchiya, Fumitaka Kumazawa, Mitsuhiro Shikida, Hiroyuki Honda

ECS Transactions Vol. 16 ( 17 ) page： 15-20 2009

部屋の住み心地に及ぼす物理的・感覚的因子の組み合わせ解析－ファジィニューラルネットワークによる住居環境解析－

牛田泰徳、加藤竜司、守本とも子、本多裕之

日本感性工学会論文誌 Vol. 9 ( 1 ) page： 97-102 2009

Growth Inhibition of Re-Challenge B16Melanoma Transplant by Conjugates of Melanogenesis Substrate and Magnetite Nanoparticles as the Basis for Developing Melanoma-Targeted Chemo-Thermo-Immunotherapy Reviewed

Tomoaki Takada, Toshiharu Yamashita, Makito Sato, Aki Tomoaki Takada, Toshiharu Yamashita, Makito Sato, Akiko Sato, Ichiro Ono, Yasuaki Tamura, Noriyuki Sato, Atsushi Miyamoto, Akira Ito, Hiroyuki Honda, KazumasaWakamatsu, Shosuke Ito and Kowichi Jimbow

Journal of Biomedicine and Biotechnology 2009

Expression Profiling of Peripheral-Blood Mononuclear Cells from Patients with Chronic Hepatitis C Undergoing Interferon Therapy Reviewed

Makoto Tateno, Masao Honda, Takashi Kawamura, Hiroyuki Honda, and Shuichi Kaneko

The Journal of Infectious Diseases Vol. 32 ( 9 ) page： 742-747 2008.4

The complementarity of the technical tools of tissue engineering and the concepts of artificial organs for the design of functional bioartificial tissues Reviewed

Petros Lenas1, Angel Moreno, Laertis Ikonomou, Joerg Mayer, Hiroyuki Honda, Antonio Novellino, Camilo Pizarro, Eleni Nicodemou-Lena, Silvia Rodergas, Jesus Pintor

Artificial Organs Vol. 32 ( 9 ) page： 742-746 2008.4

Kamihira : Construction of 3D tissue-like structure using functional magnetite nanoparticles Reviewed

Akira Ito, Hiroyuki HondaMasamichi

Yakugaku Zasshi Vol. 128 ( 1 ) page： 21-28 2008.4

Hyperthermic treatment of DMBA-induced rat mammary cancer using magnetic nanoparticles Reviewed

Jun Motoyama, Noriyuki Yamashita, Tomio Morino, Takeshi Kobayashi, Hiroyuki Honda

BioMagnetic Research and Technology Vol. 6 ( 2 ) 2008

Effect of global transcriptional regulators related to carbohydrate metabolism on organic solvent tolerance in Escherichia coli Reviewed

Mina Okochi, Masaki Kurimoto, Kazunori Shimizu, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 105 ( 4 ) page： 389-394 2008

Fabrication of vertically-aligned carbon nanotube electrodes using grid-inserted plasma-enhanced chemical vapor deposition for chemical sensors Reviewed

Yoshihiro Kojima, Shigeru Kishimoto, Mina Okochi, Hiroyuki Honda, Takashi Mizutani

Japanese Journal of Applied Physics Vol. 47 ( 4 ) page： 2028-2031 2008

A palmtop-sized rotary-drive-type biochemical analysis system by magnetic bead handling Reviewed

Mitsuhiro Shikida, Nobuhiro Nagao, Rentaro Imai, Hiroyuki Honda, Mina Okochi, Hiroshi Ito, Kazuo Sato:

of Micromechanics and Microengineering Vol. 18 ( 065012(9pp) ) 2008

Cell culture arrays using magnetic force-based cell patterning for dynamic single cell analysis Reviewed

Kosuke Ino, Mina Okochi, Nao Konishi, Masahiro Nakatochi, Rentaro Imai, Mitsuhiro Shikida, Akira Ito and Hiroyuki Honda

Lab on a Chip Vol. 8 page： 134-142 2008

Size dependent heat generation of magnetite nanoparticles under AC magnetic field for cancer therapy Reviewed

Jun Motoyama, Toshiyuki Hakata, Ryuji Kato, Noriyuki Yamashita, Tomio Morino, Takeshi Kobayashi, Hiroyuki Honda

BioMagnetic Research and Technology Vol. 6 page： 4 2008

Use of erythrocyte adhesion assay to predict the risk of diabetic complications Reviewed

Yayoi Isaji, Mina Okochi, Fumihiko Horio, Hiroyuki Honda

Biochemical Engineering Journal Vol. 43 page： 178-184 2008

Cancer DNA microarray analysis considering multi-subclass with graph-based clustering method Reviewed

Takashi Kawamura, Hironori Mutoh, Yasuyuki Tomita, Ryuji Kato, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 106 ( 5 ) page： 442-448 2008

心理・背景因子データからの妊産期うつ病発症リスク診断 Reviewed

冨田康之、加藤竜司、野坂幸世、武藤裕紀、富田真紀子、濱田祥子、涌井陽子、金井篤子、村瀬聡美、臼井比奈子、石川直子、廣瀬允美、水野妙子、後藤節子、尾崎紀夫、本多裕之

生物工学会誌 Vol. 86 ( 11 ) page： 519-523 2008

A motif detection and classification method for peptide sequences using genetic programming Reviewed

Yasuyuki Tomita, Ryuji Kato, Mina Okochi, and Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 106 ( 2 ) page： 154-161 2008

Peptide array-based screening of human mesenchymal stem cell-adhesive peptides derived from fibronectin type III domain Reviewed

Mina Okochi, Shigeyuki Nomura, Chiaki Kaga, Hiroyuki Honda

Biochemical and Biophysical Research Communications Vol. 371 ( 1 ) page： 85-89 2008

On-chip polymerase chain reaction microdevice employing a magnetic droplet-manipulation system Reviewed

Hiroyoshi Tsuchiya, Mina Okochi, Nobuhiro Nagao, Mitsuhiro Shikida and Hiroyuki Honda

Sensors & Actuators:B. Chemical Vol. 130 ( 2 ) page： 583-588 2008

Effect of heat therapy using magnetic nanoparticles conjugated with cationic liposomes on prostate tumor in bone Reviewed

Noriyasu Kawai, Mituru Futakuchi, Tatsuro Yoshida, Akira Ito, Shinya Sato, Taku Naiki, Hiroyuki Honda :

Prostate Vol. 68 ( 7 ) page： 784-792 2008

Overexpression of prefoldin from the hyperthermophilic archaeum Pyrococcus horikoshii OT3 endowed Escherichia coli with organic solvent tolerance Reviewed

Mina Okochi, Kei Kanie, Masaki Kurimoto, Masafumi Yohda, Hiroyuki Honda

Applied Microbiology and Biotechnology Vol. 79 page： 443-449 2008

Plasmid DNA transfection Using magnetite cationic liposomes for construction of multilayered gene-engineered cell sheet Reviewed

Kosuke Ino, Tamayo Kawasumi, Akira Ito, Hiroyuki Honda

Biotechnology and Bioengineering Vol. 100 ( 1 ) page： 171-179 2008

Identification of HLA-A24-restricted epitopes with high affinity to Hsp70 using peptide array Reviewed

Mina Okochi, Hiroki Hayashi, Akira Ito, Ryuji Kato, Yasuaki Tamura, Noriyuki Sato, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 105 ( 3 ) page： 198-203 2008

Screening of cell adhesive peptide from the human laminin-5 α3 chain globular 2 and 3 dimains Reviewed

Shigeyuki Nomura, Chiaki Kaga, Ryuji Kato, Mina Okochi, Hiroyuki Honda:

Journal of Chemical Engineering of Japan Vol. 41 ( 3 ) page： 206-209 2008

Computationally-assisted screening and design of cell-interactive peptides by a cell-based assay using peptide arrays and a fuzzy neural network algorithm Reviewed

Chiaki Kaga, Mina Okochi, Yasuyuki Tomita, Ryuji Kato, Hiroyuki Honda

Biotechniques Vol. 44 ( 3 ) page： 393-402 2008

Proposal of newly gene filtering method, Bag PART, for gene expression analysis with small samples Reviewed

Takashi Kawamura, Hiro Takahashi, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 105 ( 1 ) page： 81-84 2008

Incorporating of capillary-lake structures into dermal cell sheets constructed by magnetic force-bases tissue engineering Reviewed

kousuke Ino, Akira Ito, Hirohito Kumazawa, Hideaki Kagami, Minoru Ueda, Hiroyuki Honda

Journal of Chemical Engineering Japan Vol. 40 ( 1 ) page： 51-58 2007

Heat immunotherapy with heat shock protein expression by hyperthermia using magnetite nanoparticles Reviewed

Akira Ito, Takeshi Kobayashi, Hiroyuki Honda

Ann.Cancer Res.Therap. Vol. 15 ( 2 ) page： 27-34 2007

異臭味産生藻類のファジイニューラルネットワークによる増殖要因解析 Reviewed

石橋良信、及川栄作、本多裕之、安達智広、中杤昌弘

環境工学研究論文集 Vol. 44 page： 255-263 2007

Application of an ultra-water-repellent surface to cell culture Reviewed

Kosuke Ino, Akira Ito, Yunying Wu, Nagahiro Saito, Eri Hibino, Osamu Takai, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 104 ( 5 ) page： 420-423 2007

爪部悪性黒色腫のための周期的パターン抽出法の開発 Reviewed

中杤昌弘、古賀弘、斎田俊明、小林　猛、本多裕之

化学工学論文集 Vol. 33 ( 6 ) page： 570-580 2007

Screening of a novel octamer peptide, CNSCWSKD, that induces caspase-dependent cell death Reviewed

Chiaki Kaga, Mina Okochi, Mari Nakanishi, Hiroki Hayashi, Ryuji Kato, Hiroyuki Honda

Biochemical and Biophysical Research Communications Vol. 362 ( 4 ) page： 1063-1068 2007

Investigation of the relationship between sample size and risk factors for complex diseases based a simulation study Reviewed

Yasuyuki Tomita, Masahiro Nakatochi, Hiroyuki Asano, Hideo Izawa, Norio Sugimoto, Mitsuhiro Yokota, Hiroyuki Honda

Chemical-Bioinformatics Journal Vol. 7 ( 1 ) page： 1-11 2007

Mag-Seeding of Rat Bone Marrow Stromal Cells into Porous Hydroxyapatite Scaffolds for Bone Tissue Engineering Reviewed

Kazunori Shimizu, Akira Ito and Hiroyuki

Journal of Bioscience and Bioengineering Vol. 104 ( 3 ) page： 171-177 2007

Bone tissue engineering with human mesenchymal stem cell sheets constructed using magnetite nanoparticles and magnetic force Reviewed

Kazunori Shimizu, Akira Ito, Tatsuro Yoshida, Yoichi Yamada, Minoru Ueda, Hiroyuki Honda

Journal of Biomedical Material Reseach Part B Vol. 82 ( 2 ) page： 471-480 2007

Cell patterning using magnetite nanoparticles and magnetic force Reviewed

Kosuke Ino, Akira Ito, Hiroyuki Honda

Biotechnology and Bioengineering Vol. 97 ( 5 ) page： 1309-1317 2007

Effective cell-seeding using magnetite nanoparticles and magnetic force onto decellularized blood vessels for vascular tissue engineering Reviewed

Kazunori Shimizu, Akira Ito, Manabu Arinobe, Yosuke Murase, Yoshihisa Iwata, Yuji Narita, Hideaki Kagami, Minoru Ueda, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 103 ( 5 ) page： 472-478 2007

Association study between apolipoprotein L and schizophrenia by using exhaustive and rule-based analysis method for the identification of multilocus interactions Reviewed

Yasuyuki Tomita, Masashi Ikeda, Hironori Mutoh, Toshiya Inada, Nakao Iwata, Noriko Ozaki, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 103 ( 4 ) page： 303-310 2007

Increased organic solvent tolerance by overexpression of manXYZ in Escherichia coli Reviewed

Mina Okochi, Masaki Kurimoto, Kazunori Simizu, Hiroyuki Honda

Applied Microbiogy Biotechnology Vol. 73 ( 6 ) page： 1394-1399 2007

Construction of multi-layered cardiomyocyte sheets using magnetite nanoparticles and magnetic force Reviewed

Kazunori Shimizu, Akira Ito, Jong-kook Lee, Tatsuro Yoshida, Keiko Miwa, Hisaaki Ishiguro, Yasushi Numaguchi, Toyoaki Murohara, Itsuo Kodama, Hiroyuki Honda

Biotechnology and Bioengineering Vol. 96 ( 4 ) page： 803-809 2007

Enhanced activity of 3d-hydroxysteroid dehydrogenase by addition of the co-solvent 1-butyl-3-methylimidazolium (L)-lactate in aqueous phase of biphasic systems for reduction of steroids Reviewed

Mina Okochi, Izumi Nakagawa, Takeshi Kobayashi, Shuhei Hayashi, Shintoro Furusaki, Hiroyuki Honda(2007

Journal of Biotechnology Vol. 128 page： 376-382 2007

4-S-Cysteaminylphenol-loaded magnetite cationic liposomes for combination therapy of hyperthermia with chemotherapy against malignant melanoma Reviewed

Akira Ito, Masatake Fujioka, Tatsuro Yoshida, Kazumasa Wakamatsu, Shousuke Ito, Toshiharu Yamashita, Kowichi Jimbow, Hiroyuki Honda

Cancer Science Vol. 98 ( 3 ) page： 424-430 2007

New cancer diagnosis method with exhaustive maker gene selection and reliable prediction modeling using boosting and projective adaptive resonance theory with improved reliable index Reviewed

Hiro Takahashi, Yasuyuki Murase Takeshi Kobayashi and Hiroyuki Honda

Biochemical Engineering Journal Vol. 33 page： 100-109 2007

Prediction of peptide binding to major histocompatibility complex class II molecules through use of boosted fussy classfier with SWEEP operator method Reviewed

Hiro Takahashi and Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 101 ( 2 ) page： 137-141 2006

Gene expression property of high density three-dimensional tissue of Hep G2 formed in Radial –flow bioreactor Reviewed

Tomokatsu Hongo, Mariko Kajikawa, Seiichi Isida, Shougo Ozawa, Yasuo Ono, Junichi Sawada, Youichi Ishikawa, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 101 ( 3 ) page： 243-250 2006

Pentamer peptide from Fas antigen ligand inhibits tumor-growth with solid-bound form found by peptide array Reviewed

Ryuji Kato, Yukako Okuno, Chiaki Kaga, Mitoshi Kunimatsu, Takeshi Kobayashi, and Hiroyuki Honda

Journal of Peptide Research Vol. 66 page： 146-153 2006

Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core Reviewed

Noriyasu Kawai, Akira Ito, Yoko Nakahara, Hiroyuki Honda, Takeshi Kobayashi, Mitsuru Futakuchi, Tomoyuki Shirai, Keiichi Tozawa, Kenjiro Kohri

The Prostate Vol. 66 page： 718-727 2006

Proposal of pumpless, valveless, and flowless miniaturized reactor using magnetic beads for a portable gene analysis device Reviewed

Hiroshi Ito, Kentaro Takayanagi, Mina Okochi, Mitsuhiro Shikida, Kazuo Sato, Hiroyuki Honda

Journal of Chemical Engineering Japan Vol. 39 ( 12 ) page： 1296-1299 2006

Classification method for predicting the development of myocardial infarction by using interaction between genetic and environmental factors Reviewed

Yasuyuki Tomita, Hiroyuki Asano, Hideo Izawa, Mitsuhiro Yokota and Hiroyuki Honda

IPSJ Transactions on Bioinformatics Vol. 47 ( SIG 17(TBIO 1) ) page： 48-66 2006

Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: a novel concept of "heat-controlled necrosis" with heat shock protein expression Reviewed

Akira Ito, Hiroyuki Honda, Takeshi Kobayashi

Cancer Immunol Immunother Vol. 55 ( 3 ) page： 320-328 2006

Development of an enzymatic reaction device using magnetic bead-cluster handling Reviewed

Mitsuhiro Shikida, Kentaro Takayanagi, Hiroyuki Honda,, Hiroshi Ito, Kazuo Sato

Journal of Micromechanics and Microengineering Vol. 16 page： 1875-1883 2006

Cancer diagnosis marker extraction for soft tissue sarcomas based on gene expression profiling data using the projective adaptive resonance theory (PART)filtering method Reviewed

Takeshi Nemoto, Teruhiko Yoshida, Hiroyuki Honda and Tadashi Hasegawa

BMC Bioinformatics Vol. 399 ( 7 ) page： 1-11 2006

Classification of intramural metastases and lymph node metastases for esophageal cancer from gene expression by using boosting and projective adaptive resonance theory Reviewed

Hiro Takahashi, Kazuhiko Aoyagi, Yukihiro Nakanishi, Hiroki Sasaki, Teruhiko Yoshida, Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 102 ( 1 ) page： 46-52 2006

Lymphoma prognostication from expression profiling using a combination method of boosting and projective adaptive resonance theory Reviewed

Hiro Takahashi, Hiroyuki Honda

Journal of Chemical Engineering of Japan Vol. 39 ( 7 ) page： 767-771 2006

a new simple and practical gene filtering approach based on the concept of projective adaptive resonance theory (PART) filtering method Reviewed

Hiro Takahashi, Hiroyuki Honda : Modified signal-to-noise

Bioinformatics Vol. 22 ( 13 ) page： 1662-1664 2006

Fabrication of antigen sensors using carbon nanotubu field effect transistors Reviewed

Kentaro Tani, Hiroshi Ito, Yutaka Ohno, Shigeru Kishimoto, Mina Okochi, Hiroyuki Honda and Takashi Mizutani

Japanese Journal of Applied Physics Vol. 45 ( 6B ) page： 5481-5484 2006

Peptide array based interaction assay of solid-bound peptide and anchorage-dependant cells and its effectiveness in cell-adhesive peptide design Reviewed

Ryuji Kato, Chiaki Kaga, Mitoshi Kunimatsu, Takeshi Kobayashi and Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 101 ( 6 ) page： 485-495 2006

Construction of robust prognostic predictors by using projective adaptive resonance theory as a gene filtering method Reviewed

Hiro Takahashi, Takeshi Kobayashi and Hiroyuki Honda

Bioinformatics Vol. 21 ( 2 ) page： 179-186 2005

High-throughput screening of cell death inducible short peptides from TNF-related apoptosis-inducing ligand sequence Reviewed

Mina Okochi, Mari Nakanishi, Ryuji Kato, Takeshi Kobayashi, and Hiroyuki Honda

FEBS Letter Vol. 580 ( 3 ) page： 885-889 2005

A new reliable cancer diagnosis method using boosted fuzzy classifier with SWEEP operator method Reviewed

Hiro Takahashi and Hiroyuki Honda

Journal of Chemical Engineering of Japan Vol. 38 page： 763-773 2005

Exhaustive exploring using artificial neural network for identification of SNPs combination related to helicobacter pylori infection susceptibility Reviewed

Hironori Mutoh, Nobuyuki Hamajima, Takeshi Kobayashi and Hiroyuki Honda

Chemical Bio Informatics Journal Vol. 5 ( 2 ) page： 15-26 2005

Magnetic force-based mesenchymal stem cell expansion using antibody-conjugated magnetoliposomes Reviewed

Akira Ito, Eri Hibino, Kazunori Shimizu, Takeshi Kobayashi, Yoichi Yamada, Hideharu Hibi and Minoru Ueda and Hiroyuki Honda

Journal of Biomedical, Materials Research: Part B-Applied Biomaterials Vol. 75 ( 2 ) page： 320－327 2005

Complete regression of hereditary melamona in a mouse model by repeated hyperthermia using magnetite cationic liposomes Reviewed

Akira Ito, Yoko Nakahara, Masatake Fujioka, Takeshi Kobayashi, Kazue Takeda, Izumi Nakashima and Hiroyuki Honda

Japanese Journal of Hyperthermic Oncology Vol. 21 ( 3 ) page： 139-149 2005

A novel methodology for fabrication of tissue-engineered tubular constructs using magnetite nanoparticles and magnetic force Reviewed

Akira Ito, Kousuke Ino, Masao Hayashida, Takeshi Kobayashi, Hiroshi Matsumura, Hideaki Kagami, Minoru Ueda and Hiroyuki Honda

Tissue Engineering Vol. 11 ( 9/10 ) page： 1553-1561 2005

Novel strategy for protein exploration High-throughput screening assisted with fuzzy neural network Reviewed

Ryuji Kato, Hideo Nakano, Hiroyuki Konishi, Katsuya Kato, Yuchi Koga, Tsuneo Yamane, Takeshi Kobayashi and Hiroyuki Honda

Journal of Molecular Biology Vol. 351 page： 683-692 2005

Intratumoral injection of immature cells enhances antitumor effect of hyperthermia using magnetic nanoparticles Reviewed

Kouji Tanaka, Akira Ito, Takeshi Kobayashi, Tatsuyoshi Kawamura, Shinji Shimada, Kazuhiko Matsumoto, Toshiaki Saida and Hiroyuki Honda

Int. J of Cancer Vol. 116 page： 624-633 2005

Construction and delivery of tissue-engineering human retinal pigment epithelial cell sheets using magnetite nanoparticles and magnetic force Reviewed

Akira Ito, Eri Hibino, Hiroyuki Honda Chiaki Kobayashi, Hiroko Terasaki, Hideaki Kagami, Minoru Ueda and Takeshi Kobayashi

Tissue Engineering Vol. 11 ( 3/4 ) page： 489-496 2005

Using wettability and interfacial tension to handle droplets of magnetic beads in a micro-chemical-analysis system Reviewed

Mitsuhiro Shikida, Kentaro Takayanagi, Kohta Inouchi, Hiroyuki Honda and Kazuo Sato

Sensors and Actuators B Vol. 113 page： 563-569 2005

Association between Helicobacter pylori seropositivity and NAD(P)H:quinone oxidoreductase 1(NQO1)C609T polymorphism observed in outpatients and health checkup examinees Reviewed

Yasuyuki Goto, Nobuyuki Hamajima, Hiroyuki Honda, Keitaro Matsuo, Kazuhito Yamamoto, Akiko Tamakoshi, Takefumi Ando and Hidemi Goto

Gastric Cancer Vol. 8 page： 12-17 2005

The effect of RGD peptide-conjugated magnetite cationic liposomes on cell growth and cell sheet harvesting Reviewed

Akira Ito, Kousuke Ino, Takeshi Kobayashi and Hiroyuki Honda

Biomaterials Vol. 26 page： 6185-6193 2005

Three-dimensional high density culture of HepG2 cells in a 5-ml radial-flow bioreactor for construction of atificial liver Reviewed

Tomokatu Hongo, Mariko Kajikawa, Seiichi Ishida, Shogo Ozawa, Yoichi Ishikawa, Takeshi Kobayashi and Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 99 ( 3 ) page： 237-244 2005

Discovery of glpC, an organic solvent tolerance-related gene in Escherichia coli, using gene expression profiles from DNA microarrays Reviewed

Kazunori Shimizu, Shuhei Hayashi, Takeshi Kako, Maiko Suzuki, Norihiko Tsukagoshi, Noriyuki Doukyu, Takeshi Kobayashi and Hiroyuki Honda

Applied and Environmental Microbiology Vol. 71 ( 2 ) page： 1093-1096 2005

Time-course data analysis of gene expression profiles reveals purR regulon concerns in organic solvent tolerance in Escherichia coli Reviewed

Kazunori Shimizu, Shuhei Hayashi, Noriyuki Doukyu, Takeshi Kobayashi, and Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 99 ( 1 ) page： 72-74 2005

Antitumor effect of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma

Akira Ito,Fumiko Matsuoka,Hiroyuki Honda and Takeshi Kobayashi

Cancer Immunology and Immunotherapy Vol. 53 page： 26-32 2004

Artificial neural network approach for selection of casual single nucleotide polymorphisms and construction of prediction model on childhood allegic asthma

Yasuyuki Tomita,Shuta Tomita,Yuko Hasegawa,Yoichi Suzuki,Taro Shirakawa,Takeshi Kobayashi and Hiroyuki Honda

BMC Bioinformatics Vol. 5 page： 120 2004

Tissue engineering using magnetite nanoparticles and magnetic force:heterotypic layers co-cultured hepatocytes and endothelial cells

Akira Ito,Yohei Kuga,Hiroyuki Honda,Ken-ichiro Hata,Hideaki Kagami,Minoru Ueda and Takeshi Kobayashi

Tissue Engineering Vol. 10 ( 5/6 ) page： 833-840 2004

A new methodology of mesenchymal stem cell expansion using magnetic nanoparticles

Akira Ito,Eri Hibino,Hiroyuki Honda,Ken-ichiro Hata,Hideaki Kagami,Minoru Ueda and Takeshi Kobayashi

Biochemical Engineering Journal Vol. 20 page： 119-125 2004

Angiotensin Ⅱinhibitory peptide found in the receptor sequence using peptide array

Ryuji Kato,Mitoshi Kunimatsu,Seigo Fujimoto,Takeshi Kobayashi and Hiroyuki Honda

Biochemical and Biophysical research Communications Vol. 315 page： 22-29 2004

Local hyperthermia enhances thromobosis in aneurysms containing platinum colis Reviewed

Osamu Suzuki, Shigeru Miyachi, Takeshi Okamoto, Akira Ito, Masashige Shinkai, Hiroyuki Honda, Takeshi Kobayashi, Makoto Neguro and Jun Yoshida

Interventional Neuroradiology Vol. 10 ( 3 ) page： 203-211 2004

Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma Reviewed

Fumiko Matsuoka, Masashige Shinkai, Hiroyuki Honda, Tadahiko Kubo, Takashi Sugita and Takeshi Kobayashi

BioMagnetic Research and Technology Vol. 2 page： 3 2004

Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia Reviewed

Akira Ito, Yuko Kuga, Hiroyuki Honda, Hiroyuki Kikkawa, Atsushi Horiuchi, Yuji Watanabe and Takeshi Kobayashi

Cancer Letters Vol. 212 page： 167-175 2004

Construction and harvest of multilayered keratinocyte sheets using magnetite nanoparticles and magnetic force Reviewed

Akira Ito, Masao Hayashida, Hiroyuki Honda, Ken-ichiro Hata, Hideaki Kagami, Minoru Ueda and Takeshi Kobayashi

Tissue Engineering Vol. 10 ( 5/6 ) page： 873-880 2004

Evaluation of the Alzheimer type-dementia by magnetic resonance imaging using fuzzy neural networks Reviewed

Xicheng Liu, Shin Hibino, Yoshihiro Hasegawa, Taizo Hanai, Takeo Mitsushima, Akihiko Iida, Michitaka Matsubara Hiroyuki Honda and Takeshi Kobayashi

Journal of Chemical Engineering of Japan Vol. 37 ( 3 ) page： 429-435 2004

Proposal of reliability index in search for reliable solutions of reversible calculation based on fuzzy neural network modeling Reviewed

Taizo Hanai, Naoya Iwata, Takeshi Furuhashi, Hiroyuki Honda and Takeshi Kobayashi

Journal of Chemical Engineering of Japan Vol. 37 ( 4 ) page： 523-530 2004

A preprocessing method for inferring genetic interaction from gene expression data using Boolian algorithm Reviewed

Kazumi Hakamada, Taizo Hanai, Hiroyuki Honda and Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 98 ( 6 ) page： 457-468 2004

Prognostic predictor with multiple fuzzy neural models using expression profiles for metastases of breast cancer Reviewed

Hiro Takahashi, Kayoko Masuda, Tatsuya Ando, Takeshi Kobayashi, and Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 98 ( 3 ) page： 193-199 2004

Transglutaminase-mediated gelatin matrices incorporating cell adhesion factors as a biomaterial for tissue engineering

Akira Ito,Atunori Mase,Masashige Shinkai,Hiroyuki Honda,Ken-ichoro Hata,Minoru Ueda and Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 95 ( 2 ) page： 196-199 2003

Complete regression of mouse mammary carcinoma with a size greater than 15mm by frequent repeated hyperthermia using magnetite nanoparticles

Akira Ito,Kouji Tanaka,Hiroyuki Honda,Shigeru Abe,Hideyo Yamaguchi and Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 96 ( 4 ) page： 364-369 2003

Maltiple fuzzy neural network system for outcome prediction and classification of 220 lymphoma patients on the basis of molecular profiling

Tatsuya Ando,Miyuki Suguro,Takeshi Kobayashi,Masao Seto and Hiroyuki Honda

Cancer Science Vol. 94 ( 10 ) page： 906-913 2003

Heat shock protein 70 expression induces antitumor immunity during intracellular hyperthermia using magnetic nanoparticles

Akira Ito,Masashige Shinkai,Hiroyuki Honda,Kazuhiro Yoshikawa,Shinsuke Saga,Toshihiko Wakabayashi,Jun Yoshida and Takeshi Kobayashi

Cancer Immunology and Immunotherapy Vol. 52 ( 5 ) page： 80-88 2003

Screening of stress enhancer based on analysis of gene expression profiles:hyperthermia-induced tumor necrosis by an MMP-3 inhibitor

Naoko Kato,Takeshi Kobayashi and Hiroyuki Honda

Cancer Science Vol. 94 ( 7 ) page： 644-649 2003

Proliferation and stratification of keratinocite on cultured amniotic cells for tissue Engineering

Akira Ito,Yohei Takizawa,Masashige Shinkai,Hiroyuki Honda,Ken-ichiro Hata,Minoru Ueda,Naohiko Kuno,Atsuo Itakura and Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 95 ( 6 ) page： 589-593 2003

Analysis of organic solvent tolerance in Escherichia coli using gene expression profiles from DNA microarrays

Shuhei Hayashi,Rikizo Aono,Taizo Hanai,Hirotada Mori,Takeshi Kobayashi and Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 95 ( 4 ) page： 379-383 2003

Anti-cancer effect and immune inductionbyhyperthermia of malignant melanoma using magnetite cationic liposomes

Masataka Suzuki,Masashige Shinkai,Hiroyuki Honda,and Takeshi Kobayashi

Melanoma Reserch Vol. 13 ( 2 ) page： 129-135 2003

Sensory modeling of coffee with a fuzzy neural network Reviewed

Osamu Tominaga, Fumio Ito, Taizo Hanai, Hiroyuki Honda and Takeshi Kobayashi

Journal of Food Science Vol. 67 ( 1 ) page： 363-368 2002

Magnetite needle as heating mediator for intracellular hyperthermia of tumor

Masashige Shinkai,Kengo Ueno,Hiroyuki Honda and Takeshi Kobayashi

Japanese Journal of Hyperthermia Oncology Vol. 18 ( 4 ) page： 191-198 2002

Hidden Markov model-based prediction of antigenic peptides that interact with MHC class II molecules

Hideki Noguchi,Ryuji Kato,Taizo Hanai,Yukari Matubara,Hiroyuki Honda,Vladimir Brusic and Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 94 ( 3 ) page： 264-270 2002

Artificial neural network predictive model for allergic disease using single nucleotide polymorphisms data

Shuta Tomida,Taizo Hanai,Naoki Koma,Youichi Suzuki,Takeshi Kobayashi and Honda Hiroyuki

Journal of Bioscience and Bioengineering Vol. 93 ( 5 ) page： 470-478 2002

Determination of blending ratio on regular coffee samples by information technology

Osamu Tominaga,Fumio Ito,Taizo Hanai,Hiroyuki Honda and Takeshi kobayashi

Jornal of Chemical Engineering of Japan Vol. 35 ( 2 ) page： 137-143 2002

Effect of functional magnetic particles on radiofrequency capactive hesting

Masashige Shinkai,Kousuke Ueda,Shinji Ohtsu,Hiroyuki Honda,KenjiroKohri and Takeshi Kobayashi

Japanese Journal of Cancer Reserch Vol. 93 page： 103-108 2002

Magnetite needle as heating mediator for intracellular hyperthermia of tumor Reviewed

Masashige Shinkai, Kengo Ueno, Hiroyuki Honda and Takeshi Kobayashi

Japanese Journal of Hyperthermia Oncology Vol. 18 ( 4 ) page： 191-198 2002

Fuzzy Neural Network Applied to Gene Expression Profiling for Prognosis of Diffuse Large B-cell Lymphoma Reviewed

Tatsuya Ando, Miyuki Suguro, Taizo Hanai, Takeshi Kobayashi, Hiroyuki Honda and Masao Seto

Japanese Journal of Cancer Research93, 1207-1212 (2002) Vol. 93 page： 1207-1212 2002

Modeling of consumer's preferences for regular coffee samples and its application to product design Reviewed

Osamu Tominaga, Fumio Ito, Taizo Hanai, Hiroyuki Honda and Takeshi Kobayashi

Food Science and Technology Research Vol. 8 ( 3 ) page： 281-285 2002

Enhanced anthocyanin production from grape callus in an air-lift type bioreactor using a viscous additive-supplemented medium Reviewed

Hiroyuki Honda, Kousuke Hiraoka, Eiji Nagamori, Mariko Omote, Yoshihito Kato, Setsuro Hiroka and Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 94 ( 2 ) page： 135-139 2002

Analysis of expression profile using fuzzy adaptive resonance theory Reviewed

Shuta Tomida, Taizo Hanai, Hiroyuki Honda and Takeshi Kobayashi

Bioinformatics Vol. 18 ( 8 ) page： 1073-1083 2002

Production of single chain recombinant monellin by high cell density culture of genetically engineered Candida utilis using limited feeding of sodium ions Reviewed

Xiaoli Zhang, Takeshi Ito, Keiji Kondo, Takeshi Kobayashi and Hiroyuki Honda

Journal of Chemical Engineering of japan Vol. 35 ( 7 ) page： 654-659 2002

Artificial neural network predictive model for allergic disease using single nucleotide polymorphisms data Reviewed

Shuta Tomida,Taizo Hanai,Naoki Koma,Youichi Suzuki, Takeshi Kobayashi and Hiroyuki Honda

Journal of Bioscience and Bioengineering Vol. 93 ( 5 ) page： 470-478 2002

茶葉ポリフェノール物質による貝類の海藻摂食活性の阻害 Reviewed

長森英二、服部直人、本多裕之、小林　猛

化学工学論文集 Vol. 28 ( 3 ) page： 287-291 2002

High celldensity culture of Rhodococcus erythropolis KA2-5-1 for in situ induction of dibenzothiophene degrading activity Reviewed

Hibiki Matsushita, Takahiro Sugiyama, Hiroyuki Honda and Takeshi Kobayashi

Journal of the Chinese Institute of Chemical Engineers Vol. 32 ( 3 ) page： 219-225 2001

Language：English Publishing type：Research paper (scientific journal)

To obtain cells with high dibenzothiophene (DBT) degrading activity, two phase fed-batch culture of Rhodococcus erythropolis KA 2-5-1 was carried out, which consisted of growth phase in the medium containing sulfate ion as a sulfur source and induction phase for expression of DBT degrading enzyme by DBT addition. Cell concentration of 24.3 g-dry cells/L was obtained after 30 h culture and the maximum specific degrading activity of 18.2 mmol/kg-dry cells/h was achieved at 10 h after induction. In order to simplify the system and lower an operational cost, next, in situ induction of the enzyme activity was conducted by means of sulfur limitation since the activity of the strain can only be induced under sulfur starvation. The strain was cultivated in fed-batch mode in the modified A medium containing 96 mg/L of sulfate ion. At 22 h, sulfate concentration decreased below 10 mg/L and approximately 10 g/L of cell concentration was obtained. When 125 mg/L of DBT was added at 22 h, the enzyme activity increased rapidly and the maximum specific activity of 14.3 mmol/kg-dry cells/h was obtained at 28 h. However, the DBT degrading activity decreased rapidly thereafter. From the assay of remaining concentration of medium components in the culture broth, it was found that Fe and Mg ions were exhausted at the end of cultivation. Fed-batch culture with feeding of concentrated solution of Fe and Mg ions was then conducted. After 23 h, 125 mg/L of DBT was added, and the enzyme activity increased rapidly. In this case, the activity did not decrease, and the maximum specific degrading activity of 18.5 mmol/kg-dry cells/h and cell concentration of 41.7 g-dry cells/L were obtained at 34 h.

Determination of operating conditions in activated sludge process using fuzzy neural network and genetic algorithm Reviewed

Hiroyuki Yoshikawa, Taizo Hanai, Shuta Tomida, Hiroyuki Honda, and Takeshi Kobayashi

Journal of Chemical Engineering of Japan Vol. 34 ( 8 ) page： 1033-1039 2001

Fussy neural network model for assessment of Alzheimer-type dementia Reviewed

Shin Hibino, Taizo Hanai, Erika Nagata, Michitaka Matsubara, Kazutoshi Fukagawa, Tatsuaki Shirataki, Hiroyuki Honda, and Takeshi Kobayashi

Journal of Chemical Engineering of Japan Vol. 34 ( 7 ) page： 936-942 2001

Enhanced and prolonged production of regenerated plantlet from carrot callus in viscous additive-supplemented medium Reviewed

Eiji Nagamori, Mariko Omote, Hiroyuki Honda and Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 91 ( 3 ) page： 283-287 2001

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

To reduce the hydrodynamic stress in plant cell culture and enhance the production of regenerated plantlets, a liquid medium containing a viscous additive was newly designed and plantlet production from embryogenic carrot callus cultivated in the medium was examined. Na-Alginate or carboxymethyl cellulose (CMC) was used as the viscous additive. The viscosity of the medium increased with increasing additive content and the number of regenerated plantlets also increased. When carrot calli were cultivated in the medium containing 0.4% CMC, designated as N medium (viscosity, 3 mPa・s), the maximum enhancement of plantlet regeneration, approximately 2.5 times higher than that in the control medium, was obtained. Enlargement of callus size observed in N medium is considered to be the main reason for the enhanced plantlet regeneration. Regeneration enhancement was sufficiently induced after calli were cultivated once in N medium, but this regenerarion ability rapidly disappeared after once cultivation in the conventional medium. In repeated batch culture using N medium, plantlet production continued at a high level for 18 batches (250 d) with no significant decrease, while in the control culture without CMC the number of plantlets produced dropped to almost zero by the sixth batch (84 d).

Lipase production in two step fed-batch culture of an organic solvent-tolerant Pseudomonas aeruginosa LST-03 Reviewed

Takeshi Ito, Hirokazu Kikuta, Eiji Nagamori, Hiroyuki Honda, Hiroyasu Ogino, Haruo Ishikawa and Takeshi Kobayashi

Journal of Bioscience and Bioengineering Vol. 91 ( 3 ) page： 245-250 2001

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Efficient lipase production by two-step fed-batch culture of an organic solvent-tolerant bacterium, Pseudomonas aeruginosa LST-03, was investigated. When FB synthetic medium was used in flask culture, no lipase activity was detected, whereas lipase was produced at 2.3 I.U./ml in C2 complex medium. However, lipase production was induced in FB medium when a fatty acid was added to the culture broth in the stationary phase. Among fatty acids tested, long chain saturated fatty acids, such as C18 (stearic acid) and C20 (arachidic acid), were found to function as effective inducers for the production of lipase, giving an activity level almost the same as that obtained in C2 medium in flask culture. Two-step lipase production, comprised of a growth phase in fed-batch mode and a production phase in which lipase was induced by the addition of 5 %(v/v) stearic acid, was carried out in a jar-fermentor. In the growth phase, the maximum cell concentration at 16 h was only 20 in terms of the optical density at 660nm (OD660), and a low level of lipase production (8 I.U./ml) was obtained after 167 h. This was considered to be due to the exhaustion of several medium components brought about by the use of an unsuitable medium or feeding solution. After analyzing the contents of the compounds in the culture broth by inductively coupled plasma spectrometry for metal ions and HPLC for anions, a modified FB medium was designed. When this modified FB medium was used in two-step fed-batch culture, the maximum cell concentration reached an OD660 of 55 (30.2 g-dry cells/l) at 16.5 h, and lipase was produced at 96 I.U./ml after 35 h, which is approximately 40 times higher than the production level obtained in flask culture using C2 medium.

Fuzzy neural network-based prediction of the motif for MHC class II binding peptides Reviewed

Hideki Noguchi, Taizo Hanai, Hiroyuki Honda, Leonard C. Harrison and Takeshi Kobayashi

Journal of Biosience and Bioengineering Vol. 92 ( 3 ) page： 227-231 2001

Optimization of bovine cathepsin C production by cultivation of recombinant methylotrophic yeast Candida oidinii

Hiroyuki Kikuta, Kenjiro Kano, Hiroyuki Honda and Takeshi Kobayashi

Jornal of hemical Engineering of Japan Vol. 34 ( 6 ) page： 848-851 2001

Augmentation of MHC class I antigen presentation via heat shock protein expression by hyperthermia Reviewed

Akira Ito, Masashige Shinkai, Hiroyuki Honda, Toshihiko Wakabayashi, Jun Yoshida and Takeshi Kobayashi

Cancer Immmunology and Immunotherapy Vol. 50 page： 515-522 2001

知的推論モデルによる品質の定量化と培養プロセスの管理

本多裕之

生物工学会誌 Vol. 78 ( 3 ) page： 94-100 2000

Fuzzy control of bioprocess in Japan

Biotechnology Annual Review Vol. 5 page： 1-23 2000

Development of chitosan-magnetite aggregates containing Nitrosomonas europaea cells for nitrification enhancement

Journal of Bioscience and Bioengineering Vol. 89 ( 5 ) page： 420-425 2000

Selection of embryogenic sugarcane callus by image analysis

Journal of Bioscience and Bioengineering Vol. 87 ( 5 ) page： 700-702 1999

Recovery of recombinant Escherichia coli by chitosan-conjugated magnetite

Biochemical Engineering Journal Vol. 3 page： 157-160 1999

Model construction for quality of beer and brewing process using FNN

Kagaku Kogaku Ronbunshu Vol. 25 ( 5 ) page： 695-701 1999

Development of novel magnetic sensing for brain lesion using functional magnetic particles Reviewed

Masashige Shinkai, Akira Ohshima, Mitsugu Yanase, Tsuyoshi Uchiyama, Kaneo Mohri, Toshihiko Wakabayashi, Jun Yoshida, Hiroyuki Honda and Takeshi Kobayashi

Kagaku Kougaku Ronbunshu Vol. 24 ( 2 ) page： 174-178 1998

Temperature control of Ginjo sake mashing process by automatic fuzzy modeling using fuzzy networks Reviewed

Hiroyuki Honda, Taizo Hanai, Akemi Katayama, Hisao Tohyama and Takeshi Kobayashi

Journal of Fermentation and Bioengineering Vol. 85 ( 1 ) page： 107-112 1998

High cell density culture of Rhodococcus rhodochrous by pH-stat feeding and dibenzothiophene degradation Reviewed

Hiroyuki Honda, Hiroyasu Sugiyama, Ikuo Saito and Takeshi Kobayashi

Journal of Fermentation and Bioengineering Vol. 85 ( 3 ) page： 334-338 1998

Colominic acid production from Escherichia coli in a fed-batch culture under the control of ammonium ions using an FIA system

Journal of Fermentation and Bioengineering. Vol. 83 ( 1 ) page： 59-63 1997

Production of Fv fragment of monoclonal antibody from recombinant methylotrophic yeast, Pichia pastoris

Journal of Chemical Engineering of Japan Vol. 29 ( 2 ) page： 390-392 1996

Characteristics on heat sterilization of a novel autoclave with a turntable for rotation

Journal of Fermentation and Bioengineering Vol. 81 ( 6 ) page： 570-572 1996

Effective tPA production by BHK cells in nutrients-controlled culture using on-line HPLC measuring system

Journal of Fermentation and Bioengineering Vol. 80 ( 1 ) page： 107-110 1995

Effective lactic acid production by two stage extractive fermentation

Journal of Fermentation and Bioengineering Vol. 79 ( 6 ) page： 589-593 1995

Effect of additives such as anti-oxidative agent on albumin secretion from primary culture of rat hepatocyte

Biotechnology Letters Vol. 17 ( 4 ) page： 365-370 1995

Experimental fermentations of Ginjo sake with two fuzzy controls

Seibutsu-kogaku Kaishi Vol. 73 ( 4 ) page： 283-289 1995

Reduction of virus infectivity in mixed liquor of activated sludge

Vol. 16 ( 5 ) page： 339-345 1993

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