Faculty Profiles - TOKUDA Yoshiyuki

Papers - TOKUDA Yoshiyuki

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Ascorbic acid deficiency increases hepatic expression of acute phase proteins through the intestine-derived IL-6 and hepatic STAT3 pathway in ODS rats. Reviewed International journal

Kawade N, Murai A, Suzuki W, Tokuda Y, Kobayashi M, Horio F

The Journal of nutritional biochemistry Vol. 70 page： 116 - 124 2019.8

Temporary immobile leaflet following transcatheter aortic valve replacement of a SAPIEN-XT valve. Reviewed International journal

Aoki T, Tanaka A, Tokuda Y, Oshima H, Suzuki S, Ishii H

Cardiovascular intervention and therapeutics Vol. 34 ( 3 ) page： 277 - 278 2019.7

Neurologic Deficit After Aortic Arch Replacement: The Influence of the Aortic Atherosclerosis Reviewed International journal

Yoshiyuki Tokuda, Yuji Narita, Kazuro Fujimoto, Masato Mutsuga, Sachie Terazawa, Hideki Ito, Wataru Uchida, Akihiko Usui

The Annals of Thoracic Surgery Vol. 108 ( 1 ) page： 107 - 114 2019.7

Conservative treatment of type A aortic dissection following hybrid arch repair

Yoshizumi Tomo, Tokuda Yoshiyuki, Abe Tomonobu, Usui Akihiko

GENERAL THORACIC AND CARDIOVASCULAR SURGERY Vol. 67 ( 7 ) page： 602 - 607 2019.7

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Type A aortic dissection (TAAD) following hybrid arch repair (HAR) is a lethal complication. Open surgical repair is the ideal treatment, but this can be difficult, as most candidates have complications and are unsuitable for the conventional open aortic repair. We herein report three cases of TAAD after HAR and assess the treatment options. METHODS: Of 261 aortic arch repair cases between April 2010 and March 2018, 38 underwent HAR using debranching of all the arch vessels followed by stent graft implantation landing proximally in zone 0 (type 1 HAR). Three cases suffered from TAAD, and their background characteristics and post-operative outcomes were studied retrospectively. RESULTS: The three TAAD cases were elderly with a high risk of mortality due to comorbidities. TAAD for Cases 1, 2, and 3 was detected on post-operative day (POD) 11, POD11, and during the procedure, respectively. Case 1 was complicated with both respiratory and renal failures, and Case 3 suffered from severe neurological impairment when TAAD was detected. No additional open aortic repair was performed in any cases. Case 3 died on POD5 due to aortic rupture. Cases 1 and 2 have survived for more than 50 months since their initial surgeries. CONCLUSIONS: TAAD following HAR can be detected with post-operative imaging despite a lack of signs noted during the intra- and post-operative periods. Conservative therapy might, therefore, be an acceptable option for subacute-onset TAAD following HAR with stable hemodynamics, even though such patients do required a very careful follow-up.

DOI： 10.1007/s11748-019-01075-w

Fungal endocarditis after transcatheter aortic valve replacement (TAVR): Case report and review of literature. Reviewed International journal

Morioka H, Tokuda Y, Oshima H, Iguchi M, Tomita Y, Usui A, Yagi T

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 25 ( 3 ) page： 215 - 217 2019.3

Language：English Publishing type：Research paper (scientific journal)

The reported number of transcatheter aortic valve replacement-associated infective endocarditis (TAVR-IE) cases has been increasing worldwide, but information about the incidence and clinical features of fungal TAVR-IE is quite limited. We present a patient who acquired TAVR-IE caused by Candida parapsilosis four month after TAVR, who was successfully treated redo-aortic valve replacement and prolonged antifungal therapy.

DOI： 10.1016/j.jiac.2018.08.017

Dementia and Cognitive Impairment on Coronary Artery Bypass Grafting Patients in Aging Society International journal

Terazawa Sachie, Narita Yuji, Fujimoto Kazuro, Mutsuga Masato, Tokuda Yoshiyuki, Ito Hideki, Uchida Wataru, Usui Akihiko

Journal of Coronary Artery Disease Vol. 25 ( 3 ) page： 66 - 71 2019

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Coronary Association

Coronary artery bypass grafting (CABG) is strategy for complex coronary artery disease (CAD) practiced worldwide that has become to be performed in relatively elderly patients in recent years, regarding to the development of off-pump CABG. As the population of elderly patients with cognitive disorders increases, a certain proportion of CABG candidates are likely to have some degree of cognitive impairment, especially dementia. The discussions about the CABG candidates with dementia are still insufficient, although several reports have suggested that 9.6%&ndash20% of CABG candidates may have preoperative dementia. An analysis indicated higher rate of hospital mortality and delirium in dementia patients, but ideal strategies for managing such patients remain controversial. An estimated 20%&ndash35% of CABG patients may have preoperative mild cognitive impairment (MCI), which is associated with an increased risk of morbidity and poor physical recovery after CABG. This preoperative cognitive decline was identified as a predictive factor for post-operative cognitive decline (POCD). Several randomized control trial have compared the cognitive outcomes between elderly high-risk patients after CABG with or without cardiopulmonary bypass, finding no significant cognitive differences between on- and off-pump treatments at 3 to 12 months after CABG. In addition, any late cognitive decline is likely associated with the progression of underlying cerebrovascular disease rather than surgical procedure itself or cardiopulmonary bypass. Preoperative evaluations of the cognitive function may contribute to appropriate postoperative management, reduce the incidence of delirium and improve the overall surgical outcome.

DOI： 10.7793/jcad.25.010

CiNii Research

The oral administration of clarithromycin prevents the progression and rupture of aortic aneurysm. Reviewed International journal

Uchida W, Narita Y, Yamawaki-Ogata A, Tokuda Y, Mutsuga M, Lee Fujimoto K, Abe T, Oshima H, Usui A

Journal of vascular surgery Vol. 68 ( 6S ) page： 82S - 92S.e2 2018.12

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: The pathogenesis of aortic aneurysm (AA) is associated with chronic inflammation in the aortic wall with increased levels of matrix metalloproteinases (MMPs). Clarithromycin (CAM) has been reported to suppresses MMP activity. In this study, we investigated whether CAM could prevent the formation and rupture of AA. METHODS: Male apolipoprotein E-deficient mice (28-30 weeks of age) were infused with angiotensin II for 28 days. CAM (100 mg/kg/d) or saline (as a control) was administered orally to the mice every day (CAM group, n = 13; control group, n = 13). After the administration period, the aortic diameter, elastin content, macrophage infiltration, MMP levels, and levels of inflammatory cytokines, including nuclear factor κB (NF-κB), were measured. RESULTS: The aortic diameter was significantly suppressed in the CAM group (P < .001). No rupture death was observed in the CAM group in contrast to five deaths (38%) in the control group (P < .01). CAM significantly suppressed the degradation of aortic elastin (56.3% vs 16.5%; P < .001) and decreased the infiltration of inflammatory macrophages (0.05 vs 0.16; P < .01). Compared with the controls, the enzymatic activity of MMP-2 and MMP-9 was significantly reduced in the CAM group (MMP-2, 0.15 vs 0.56 [P < .01]; MMP-9, 0.12 vs 0.60 [P < .01]), and the levels of interleukin 1β (346.6 vs 1066.0; P < .05), interleukin 6 (128.4 vs 346.2; P < .05), and phosphorylation of NF-κB were also decreased (0.3 vs 2.0; P < .01). CONCLUSIONS: CAM suppressed the progression and rupture of AA through the suppression of inflammatory macrophage infiltration, a reduction in MMP-2 and MMP-9 activity, and the inhibition of elastin degradation associated with the suppression of NF-κB phosphorylation.

DOI： 10.1016/j.jvs.2017.12.047

Strategy of Cardiovascular Surgery for Patients With Dementia as Evaluated by Mini-Mental State Examination. International journal

Terazawa S, Oshima H, Narita Y, Fujimoto K, Mutsuga M, Tokuda Y, Yoshizumi T, Ito H, Uchida W, Usui A

Circulation journal : official journal of the Japanese Circulation Society Vol. 82 ( 12 ) page： 2998-3004 - 3004 2018.11

Language：English Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society

Background: The strategy for cardiovascular surgery in dementia patients is controversial, so we aimed to investigate whether preoperative dementia and its severity might affect the outcomes of cardiovascular surgery by evaluating with the Mini-Mental State Examination (MMSE). Methods and Results: The study group comprised 490 patients undergoing cardiovascular surgery. Their preoperative cognitive status was evaluated using the MMSE, and analysis was performed to compare the patients with MMSE score <24 (dementia group, n=51) or MMSE score 24–30 (non-dementia group, n=439). Furthermore, the effect of the severity of dementia was analyzed with a cut-off MMSE score of 19/20. Risk factors for surgical outcomes were explored using multivariate logistic regression analysis. Hospital mortality was 11.8% in the dementia group and 2.1% in the non-dementia group (P=0.002). Regarding the postoperative morbidities, the incidence of cerebrovascular disorder (P=0.001), pneumonia (P=0.039), delirium (P=0.004), and infection (P=0.006) was more frequent in dementia group. Among the patients with MMSE <20, hospital mortality was as high as 25%, and the rate of delirium was 58%. Multivariate logistic regression analysis revealed that MMSE score <24 (P=0.003), lower serum albumin (P=0.023) and aortic surgery (P=0.036) were independent risk factors for hospital death. Conclusions: Preoperative dementia affects the outcomes of cardiovascular surgery with regard to hospital death and delirium. The surgical indication for patients with MMSE <20 might be difficult, but surgery with an appropriate strategy should be considered for patients with MMSE <24.

DOI： 10.1253/circj.CJ-18-0312

The Possibility of Clarithromycin for the Treatment of Type B Aortic Dissection.

Uchida Wataru, Yamawaki-Ogata Aika, Hideki Ito, Sachie Tarazawa, Tokuda Yoshiyuki, Mutsuga Masato, Fujimoto Kazuro L., Yuji Narita, Usui Akihiko

CIRCULATION Vol. 138 2018.11

Aortic sarcoidosis complicated by a pulmonary artery aneurysm. Reviewed International journal

Uchida W, Tokuda Y, Mutsuga M, Usui A

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Vol. 54 ( 4 ) page： 786 - 788 2018.10

Placebo-Controlled, Double-Blinded Phase III Study Comparing Dexamethasone on Day 1 With Dexamethasone on Days 1 to 3 With Combined Neurokinin-1 Receptor Antagonist and Palonosetron in High-Emetogenic Chemotherapy. Reviewed International journal

Ito Y, Tsuda T, Minatogawa H, Kano S, Sakamaki K, Ando M, Tsugawa K, Kojima Y, Furuya N, Matsuzaki K, Fukuda M, Sugae S, Ohta I, Arioka H, Tokuda Y, Narui K, Tsuboya A, Suda T, Morita S, Boku N, Yamanaka T, Nakajima TE

Journal of clinical oncology : official journal of the American Society of Clinical Oncology Vol. 36 ( 10 ) page： 1000 - 1006 2018.4

Clinical outcomes and quality of life after surgery for dilated ascending aorta at the time of aortic valve replacement; wrapping versus graft replacement Reviewed International journal

Tomonobu Abe, Sachie Terazawa, Hideki Ito, Yoshiyuki Tokuda, Kazuro Fujimoto, Masato Mutsuga, Yuji Narita, Hideki Oshima, Akihiko Usui

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 79 ( 4 ) page： 443 - 451 2017.11

Language：English Publishing type：Research paper (scientific journal) Publisher：NAGOYA UNIV, SCH MED

Wrapping and graft replacement are two optional procedures for the treatment of dilated ascending aorta at the time of aortic valve replacement (AVR). Wrapping is considered less invasive. The aim of this study was to compare the short-and long-term clinical outcomes as well as the long-term quality of life in patients undergoing these two procedures. This study enrolled 40 consecutive patients with dilated ascending aorta who had undergone either wrapping (WAA group, n=20) or replacement (RAA group, n=20) of the ascending aorta at the time of AVR. Short-term outcomes, long-term deaths, and aortic events were evaluated, as was quality of life using the SF-36 Short Form. Long-term maximal proximal aortic diameter was also obtained. There were no early deaths in either group. Pump time was shorter, and transfusion (55% vs. 95%, p=0.035) and postoperative atrial fibrillation (5% vs. 30%, p=0.036) rates were lower, in the WAA than in the RAA group. At a mean follow-up of 4.9 years, the overall 5 year survival rates in the WAA and RAA groups were 78.1% and 87.5%, respectively. There were no significant between group differences in SF-36 scores in any subcategory of this survey. Long-term maximal aortic diameter remained stable in both groups. Both surgical interventions for dilated ascending aorta at the time of AVR yield favorable and comparable results in patients with suitable anatomy. Furthermore, we found no differences in quality of life between these procedures.

DOI： 10.18999/nagjms.79.4.443

Entire Circumferential Reconstruction of the Right Atrium Surrounded by Angiosarcoma Reviewed International journal

Makoto Hibino, Tomonobu Abe, Hideki Oshima, Yuji Narita, Masato Mutsuga, Kazuro L. Fujimoto, Yoshiyuki Tokuda, Koji Yamana, Taiyo Kuroda, Akihiko Usui

ANNALS OF THORACIC SURGERY Vol. 103 ( 6 ) page： e483 - e485 2017.6

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Primary cardiac angiosarcomas are frequently found at a large size with infiltration into the adjacent heart structure owing to their asymptomatic characteristics until an advanced stage. Therefore, extensive resection is often required to achieve a good prognosis. We herein report a case of entire circumferential resection of the right atrium surrounded by angiosarcoma and excellent three-dimensional reconstruction of the right atrium. (C) 2017 by The Society of Thoracic Surgeons.

DOI： 10.1016/j.athoracsur.2016.11.032

Total Arch Replacement Using Manufactured Frozen Elephant Trunk after Acute Type-A Dissection Repair

Hibino M., Mutsuga M., Oshima H., Narita Y., Abe T., Fujimoto K., Tokuda Y., Usui A.

Kyobu geka. The Japanese journal of thoracic surgery Vol. 70 ( 4 ) page： 281 - 285 2017.4

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyobu geka. The Japanese journal of thoracic surgery

The purpose of this study is to assess the result of total arch replacement(TAR) using manufactured frozen elephant trunk(FET) for chronic aortic dissection after initial repair including the effect of aortic remodeling by the FET. Between 2003 and 2015, we performed 11 TAR using manufactured FET. Initial repairs before were 9 ascending aortic replacements and 2 Bentall operations. The entry of residual dissection was located at arch in 7 and at distal anastomosis site in 4. There was no hospital death. The operative complication included 2 surgical site infection, 1 interstitial pneumonia and 1 paraplegia with almost full recovery. Postoperative computed tomography 2.1 months after operation showed distal end of the FET was located at aortic valve level in 7 and at pulmonary bifurcation level in 4. There was no entry in thoracic aorta. Thrombosis of descending aorta was achieved in 7 patients. Significant midterm aortic remodeling (increased diameter of true lumen and decreased diameter of false lumen) was achieved, although the total diameter of aorta was increased. TAR using manufactured FET after type-A dissection repair promoted entry closure and thrombosis of false lumen. It requires long-term observation to judge the effect for aortic remodeling.

Scopus

[Total Arch Replacement Using Manufactured Frozen Elephant Trunk after Acute Type-A Dissection Repair]. Reviewed International journal

Hibino M, Mutsuga M, Oshima H, Narita Y, Abe T, Fujimoto K, Tokuda Y, Usui A

Kyobu geka. The Japanese journal of thoracic surgery Vol. 70 ( 4 ) page： 281 - 285 2017.4

Early and Late Outcomes of Thoracic Aortic Surgery in Hemodialysis Patients (vol 102, pg 1282, 2016) International journal

M. Hibino, H. Oshima, Y. Narita, T. Abe, M. Mutsuga, K. L. Fujimoto, Y. Tokuda, S. Terazawa, H. Ito, A. Usui

ANNALS OF THORACIC SURGERY Vol. 103 ( 1 ) page： 366 - 366 2017.1

Increased expression of the adipocytokine omentin in the epicardial adipose tissue of coronary artery disease patients Reviewed

Vol. 251 page： 299-304 2016.7

Extended total arch replacement via the L-incision approach: single-stage repair for extensive aneurysms of the aortic arch. Reviewed

Tokuda Y, Oshima H, Narita Y, Abe T, Mutsuga M, Fujimoto K, Terazawa S, Ito H, Hibino M, Uchida W, Komori K, Usui A

Interact Cardiovasc Thorac Surg Vol. 22 ( 6 ) page： 750-755 2016.6

A 'through-and-through bowing technique' for antegrade thoracic endovascular aneurysm repair with total arch debranching: a technical note and the initial results Reviewed

Vol. 49 page： 1264-1269 2015.9

Hybrid versus open repair of aortic arch aneurysms: comparison of postoperative and mid-term outcomes with a propensity score-matching analysis. Reviewed

Tokuda Y, Oshima H, Narita Y, Abe T, Araki Y, Mutsuga M, Fujimoto K, Terazawa S, Yagami K, Ito H, Yamamoto K, Komori K, Usui A

Eur J Cardiothorac Surg. page： ezv063. [Epub ahead of print] 2015

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Papers - TOKUDA Yoshiyuki