Updated on 2021/12/07

写真a

 
AKIYAMA, Shin'ichi
 
Organization
Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Division Designated lecturer
Title
Designated lecturer

Degree 1

  1. 博士(農学) ( 2001.9   近畿大学 ) 

Research Interests 7

  1. Membranous nephropathy

  2. Systemic lupus erythematosus

  3. Biomarker

  4. Disease model fish

  5. Nephrotic syndrome

  6. 魚類養殖

  7. 低温プラズマ

Research Areas 3

  1. Life Science / Aquatic life science

  2. Energy Engineering / Applied plasma science

  3. Life Science / Nephrology

Current Research Project and SDGs 3

  1. ネフローゼ症候群の診断と治療

  2. 低温プラズマ技術による食糧増産

  3. 自己免疫疾患の診断と治療

Research History 4

  1. Fujita Health University

    2010.4

  2. Nagoya University   Designated lecturer

    2010.4

  3. Fujita Health University

    2009.10 - 2010.3

  4. Nagoya University   Designated assistant professor

    2009.7 - 2010.3

Professional Memberships 3

  1. 日本分子生物学会

  2. 日本生物工学会

  3. Japanese Society of Nephrology

Awards 8

  1. 優秀演題賞

    2020.10   第50回日本腎臓学会西部学術大会  

    秋山真一

  2. 優秀演題賞

    2020.8   第63回日本腎臓学会学術総会  

    秋山真一

  3. 優秀演題賞

    2019.10   第49回日本腎臓学会西部学術大会  

    秋山真一

  4. 優秀演題賞

    2016.6   第59回日本腎臓学会学術総会  

    秋山真一

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    Award type:Award from Japanese society, conference, symposium, etc. 

  5. 優秀演題賞

    2015.6   第58回日本腎臓学会学術総会  

    秋山真一

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    Award type:Award from Japanese society, conference, symposium, etc. 

  6. 優秀演題賞

    2014.7   第57回日本腎臓学会学術総会  

    秋山真一

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    Award type:Award from international society, conference, symposium, etc. 

  7. 優秀演題賞

    2013.5   第56回日本腎臓学会学術総会  

    秋山真一

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    Award type:Award from Japanese society, conference, symposium, etc. 

  8. Best Abstract賞

    2012.6   第57回日本透析医学会学術集会・総会  

    秋山真一

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    Award type:Award from Japanese society, conference, symposium, etc. 

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Papers 13

  1. A digest of the Evidence-Based Clinical Practice Guideline for Nephrotic Syndrome 2020 Reviewed International journal

    Wada Takehiko, Ishimoto Takuji, Nakaya Izaya, Kawaguchi Takehiko, Sofue Tadashi, Shimizu Sayaka, Kurita Noriaki, Sasaki Sho, Nishiwaki Hiroki, Koizumi Masahiro, Saito Shoji, Nishibori Nobuhiro, Oe Yuji, Yoshida Mai, Miyaoka Yoshitaka, Akiyama Shin'ichi, Itano Yuya, Okazaki Masaki, Ozeki Takaya, Ichikawa Daisuke, Oguchi Hideyo, Kohsaka Satoshi, Kosaka Shiho, Kataoka Yuki, Shima Hideaki, Shirai Sayuri, Sugiyama Kazuhiro, Suzuki Tomo, Son Daisuke, Tanaka Tomomi, Nango Eishu, Niihata Kakuya, Nishijima Yoko, Nozu Kandai, Hasegawa Midori, Miyata Rei, Yazawa Masahiko, Yamamoto Yoshihiro, Yamamoto Ryohei, Shibagaki Yugo, Furuichi Kengo, Okada Hirokazu, Narita Ichiei

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 25 ( 12 ) page: 1277 - 1285   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-021-02098-5

    Web of Science

  2. Microchip Immunoassays for Monitoring Renal Function: Rapid, Low-Cost, and Highly Sensitive Quantification of Urinary Biomarkers of Diabetic Nephropathy Reviewed International journal

    Kasama Toshihiro, Sun Miaomiao, Kaji Noritada, Akiyama Shin'ichi, Yuzawa Yukio, Tokeshi Manabu, Matsuo Seiichi, Baba Yoshinobu

    MICROMACHINES   Vol. 12 ( 11 )   2021.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/mi12111353

    Web of Science

  3. Urinary Metabolome Analyses of Patients with Acute Kidney Injury Using Capillary Electrophoresis-Mass Spectrometry Reviewed International coauthorship International journal

    Saito Rintaro, Hirayama Akiyoshi, Akiba Arisa, Kamei Yushi, Kato Yuyu, Ikeda Satsuki, Kwan Brian, Pu Minya, Natarajan Loki, Shinjo Hibiki, Akiyama Shin'ichi, Tomita Masaru, Soga Tomoyoshi, Maruyama Shoichi

    METABOLITES   Vol. 11 ( 10 )   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/metabo11100671

    Web of Science

  4. Thrombotic thrombocytopenic purpura developed during the conservative treatment of anti-phospholipase A(2) receptor antibody-positive idiopathic membranous nephropathy: a case report Reviewed International journal

    Iio Rei, Akiyama Shin'ichi, Mitsumoto Kensuke, Iwata Yukimasa, Okushima Hiroki, Shimada Karin, Ota Naomi, Tomida Kodo, Fushimi Hiroaki, Shoji Tatsuya, Matsumoto Masanori, Hayashi Terumasa

    BMC NEPHROLOGY   Vol. 21 ( 1 )   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12882-020-02086-z

    Web of Science

  5. CIRCULATING ANTI-THSD7A ANTIBODY IN JAPANESE PATIENTS WITH PRIMARY MEMBRANOUS NEPHROPATHY Reviewed International journal

    Akiyama Shin'ichi, Maruyama Shoichi

    NEPHROLOGY   Vol. 25   page: 36 - 36   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  6. Additional prognostic value of toe-brachial index beyond ankle-brachial index in hemodialysis patients Reviewed International journal

    Hishida Manabu, Imaizumi Takahiro, Menez Steven, Okazaki Masaki, Akiyama Shin'ichi, Kasuga Hirotake, Ishigami Junichi, Maruyama Shoichi, Matsushita Kunihiro

    BMC NEPHROLOGY   Vol. 21 ( 1 )   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12882-020-01991-7

    Web of Science

  7. Membranous nephropathy associated with thrombospondin type-1 domain-containing 7A (THSD7A) in an adult woman with eosinophilia Reviewed International journal

    Shirai Sayuri, Akiyama Shin'ichi, Kamijo-Ikemori Atsuko, Suzuki Tomo, Ichikawa Daisuke, Koike Junki, Kimura Kenjiro, Shibagaki Yugo

    CEN CASE REPORTS   Vol. 9 ( 1 ) page: 65 - 73   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13730-019-00430-3

    Web of Science

  8. VEGF-A Links Angiolymphoid Hyperplasia With Eosinophilia (ALHE) to THSD7A Membranous Nephropathy: A Report of 2 Cases Reviewed International journal

    Matsumoto Ayumi, Matsui Isao, Namba Tomoko, Sakaguchi Yusuke, Mizuno Hitoshi, Shirayama Yuki, Shimada Karin, Hashimoto Nobuhiro, Doi Yohei, Yamaguchi Satoshi, Kubota Keiichi, Oka Tatsufumi, Mori Daisuke, Akiyama Shinichi, Hamano Takayuki, Mizui Masayuki, Takabatake Yoshitsugu, Kaneko Tetsuya, Isaka Yoshitaka

    AMERICAN JOURNAL OF KIDNEY DISEASES   Vol. 73 ( 6 ) page: 880 - 885   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.ajkd.2018.10.009

    Web of Science

  9. Differences in peritoneal solute transport rates in peritoneal dialysis Reviewed International journal

    Asano Marina, Ishii Takako, Hirayama Akiyoshi, Mizuno Masashi, Suzuki Yasuhiro, Sakata Fumiko, Akiyama Shin-ichi, Maruyama Shoichi, Soga Tomoyoshi, Kinashi Hiroshi, Katsuno Takayuki, Ito Yasuhiko

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 23 ( 1 ) page: 122 - 134   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10157-018-1611-1

    Web of Science

    PubMed

  10. Chronic Inflammatory Demyelinating Polyneuropathy With Concurrent Membranous Nephropathy: An Anti-paranode and Podocyte Protein Antibody Study and Literature Survey Reviewed International journal

    Hashimoto Yu, Ogata Hidenori, Yamasaki Ryo, Sasaguri Takakazu, Ko Senri, Yamashita Kenichiro, Xu Zhang, Matsushita Takuya, Tateishi Takahisa, Akiyama Shin'ichi, Maruyama Shoichi, Yamamoto Akifumi, Kira Jun-ichi

    FRONTIERS IN NEUROLOGY   Vol. 9   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fneur.2018.00997

    Web of Science

  11. Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium Reviewed International journal

    Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Takeda Keigo, Hashizume Hiroshi, Nakamura Kae, Utsumi Fumi, Kajiyama Hiroaki, Okazaki Yasumasa, Toyokuni Shinya, Akiyama Shinichi, Maruyama Shoichi, Kikkawa Fumitaka, Hori Masaru

    IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES   Vol. 2 ( 2 ) page: 99 - 102   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1109/TRPMS.2017.2721973

    Web of Science

  12. A Refractory Case of Secondary Membranous Nephropathy Concurrent with IgG4-related Tubulointerstitial Nephritis Reviewed International journal

    Arai Hiroyuki, Toda Naohiro, Kamimatsuse Ryo, Nishioka Keisuke, Endo Shuichiro, Akiyama Shinichi, Maruyama Shoichi, Matsubara Takeshi, Yokoi Hideki, Yanagita Motoko

    INTERNAL MEDICINE   Vol. 57 ( 19 ) page: 2873 - 2877   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.0836-18

    Web of Science

  13. Single-dose Rituximab Therapy for Refractory Idiopathic Membranous Nephropathy: A Single-center Experience Reviewed International journal

    Katsuno Takayuki, Ozaki Takenori, Kim Hangsoo, Kato Noritoshi, Suzuki Yasuhiro, Akiyama Shinichi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Ito Yasuhiko, Maruyama Shoichi

    INTERNAL MEDICINE   Vol. 56 ( 13 ) page: 1679 - 1686   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.56.7908

    Web of Science

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Presentations 4

  1. Circulating Anti-THSD7A Antibody in Japanese Patients Membranous Nephropathy International conference

    Shin'ichi Akiyama

    2020.10.3 

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    Language:English   Presentation type:Poster presentation  

  2. ループス腎炎の新規診断指標および未知分子病態の発見

    秋山真一・平山明由・蜂矢朝香・曽我朋義・丸山彰一

    第63回日本腎臓学会学術総会  2020.8.21 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  3. 新規ループス腎炎バイオマーカー“ddhC"の臨床実装に向けた検討

    秋山真一、蜂矢朝香、立枩良崇、平山明由、丸山彰一

    第50回日本腎臓学会西部学術大会  2020.10.17 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:オンライン  

  4. Auto-antigens of membranous nephropathy Invited

    2021.9.25 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

Research Project for Joint Research, Competitive Funding, etc. 6

  1. 全身性エリテマトーデスの新規診断法

    2021.10 - 2024.3

    名古屋大学モノづくりベンチャー活動支援金 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3500000 ( Direct Cost: \3500000 )

  2. 全身性エリテマトーデスの新規診断法

    2021.10 - 2022.3

    科学技術振興機構  JST SCORE Tongali GAPファンド 

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    Authorship:Principal investigator  Grant type:Competitive

    Direct Cost: \10000000 、 Indirect Cost:\3000000 )

  3. 難治性腎疾患の疾患・重症度分類の再定義に向けた研究開発

    Grant number:21443880  2021.4 - 2024.3

    難治性疾患実用化研究事業  エビデンス創出

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\13000000 ( Direct Cost: \10000000 、 Indirect Cost:\3000000 )

  4. 全身性エリテマトーデスの診断法

    2020.4 - 2022.3

    東海広域5大学ベンチャー起業支援スタートアップ準備資金 

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    Authorship:Principal investigator 

    Grant amount:\1841917 ( Direct Cost: \1841917 )

  5. SLEおよびループス腎炎を鑑別する新規バイオマーカー用ELISAの開発

    Grant number:A104  2019.4 - 2020.3

    AMED  AMED 橋渡し研究事業 

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

  6. 特発性膜性腎症の新規責任抗原の同定

    2019.4 - 2020.3

    熊本大学  熊本大学発生医学研究所旅費支援 

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    Authorship:Principal investigator 

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KAKENHI (Grants-in-Aid for Scientific Research) 10

  1. 日本の一次性膜性腎症における新規責任抗原の同定と臨床実態および病態機序の解明

    Grant number:21K08227  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    秋山 真一, 丸山 彰一

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    成人の一次性ネフローゼ症候群の主要な原疾患である一次性膜性腎症の診療では、近年、責任抗原に対する自己抗体を指標にした新しい診療技術が開発され、血液検査で鑑別診断および免疫的病勢評価が可能になりました。しかし、日本人の一次性膜性腎症患者の45%は責任抗原が未だ不明なため、自己抗体を指標にした新しい医療技術を受けられずにいます。
    そこで、本研究では、日本人一次性膜性腎症患者の未知の責任抗原を一つでも多く解明して、最終的には、日本人の一次性膜性腎症患者の大半で自己抗体を指標にした新しい診療技術が実現することを目差します。

  2. 日本の一次性膜性腎症における責任抗原ごとの病態理解と新規診断法の確立

    Grant number:18K08239  2018.4 - 2021.3

    科学研究費助成事業  基盤研究(C)

    秋山 真一, 丸山 彰一

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    本研究では、膜性腎症の中でも責任抗原が不明な特発性膜性腎症について未知の責任抗原の解明を目指すと共に、Phospholipase A2 receptor(PLA2R)やThrombospondin 7A(THSD7A)を含む各責任抗原に対する自己抗体を指標にした病態理解および新規診断法の開発に取り組んでいる。
    研究2年目の進捗は以下の通りである。未知の責任抗原の同定では、研究1年目に開発した患者血清を用いた免疫沈降法を用いて抗原検索を継続した。また、昨年度の実験で得られた新規抗原候補となるタンパク質の同定作業にも取り組んだ。質量分析により得られた新規抗原候補群からポドサイトに発現する膜タンパク質を抽出して、各候補抗原のcDNA断片を組み込んだ発現ベクターを作成し、各種組換えタンパク質を取得した。得られた抗原タンパク質を用いて患者血清に対する結合試験を開始した。一方、既知責任抗原であるPLA2Rのエピトープ解析では、海外の先行論文にて一次性膜性腎症患者がもつ自己抗体のエピトープとして報告されているシステインリッチドメイン(CysR)、Cタイプレクチンドメイン1番(CTLD1)、Cタイプレクチンドメイン5番(CTLD5)、Cタイプレクチンドメイン7番(CTLD7)、Cタイプレクチンドメイン8番(CTLD8)に対するエピトープ分布解析に取り組んだ。各ドメインの組換えタンパク質を調製して、抗PLA2R陽性一次性膜性腎症患者の診断時血清を用いて解析を実施した。その結果、日本人患者ではエピトープ分布と病勢・予後との間に海外症例で報告されたような明瞭な相関は認められず、日本人患者では診断時の抗PLA2R抗体濃度の方がより予後との相関が強いことが示された。
    未知抗原の同定では候補抗原の発現と患者自己抗体に対する結合性確認を繰り返す作業に移行できている。自己抗体濃度やエピトープ分布による病勢・予後解析では計画通りに推進できてデータの蓄積が進んでいる。
    順調に進展しているため今後も当初の研究計画に沿って進める。具体的には、未知抗原同定とPLA2R関連膜性腎症患者およびTHSD7A関連膜性腎症患者の血清を用いた自己抗体濃度およびエピトープ分布による病勢・予後診断法の検討を進める。

  3. Study on the clinical and pathological features of PLA2R-related membranous nephropathy in Japan

    Grant number:15K09257  2015.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Akiyama Shin'ichi, Yokoyama Hitoshi, Matsusaka Taiji

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    We studied on the clinical reality and pathophysiology of PLA2R-associated membranous nephropathy, a new concept of primary membranous nephropathy, in Japanese patients. We optimized the method of measuring PLA2R antibody according to the clinical situation of Japanese patients. The PLA2R antibody measurement at the time of renal biopsy was shown not only useful for differentiation of PLA2R-related membranous nephropathy but also useful for predicting prognosis. PLA2R antibody-positive patients who have a history of smoking have been shown to delay complete remission. Patients with a PLA2R antibody concentration of 50 RU/ml or more at the time of renal biopsy were shown to have a significantly worse renal prognosis.

  4. 間葉系幹細胞の微小環境での炎症制御機構に着眼した次世代型免疫・炎症制御法の創成

    Grant number:21H04824  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(A)

    丸山 彰一, 古橋 和拡, 杉浦 悠毅, 平山 明由, 榎本 篤, 田中 章仁, 石本 卓嗣, 秋山 真一

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    既存の免疫抑制薬は過剰免疫抑制による感染症などの副作用が問題となっている。間葉系幹細胞(MSC)は、障害部位の炎症強度に応じた自律的かつ局所での炎症制御が可能なことから、次世代の免疫制御療法として期待されている。しかし、その作用機序は十分解明されておらず、その実用化に際しては課題が多い。新概念として『障害部位に到達したMSC由来細胞外小胞が炎症細胞から放出される炎症性物質と微小空間で会合した時にのみ免疫抑制物質が生成されて局所での抗炎症作用が出現する』という着想に至った。本研究では、この新概念を検証して、効果的で安全な次世代型免疫・炎症制御療法の開発に取り組む。

  5. Screening of humoral pathogenesis of idiopathic focal segmental glomerulosclerosis by proteinuria visualized transparent model animal

    Grant number:19K22618  2019.6 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  6. Analysis of the role of mesenchymal stem cell marker Meflin in glomerulonephritis

    Grant number:17H04186  2017.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    maruyama shoichi

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    We previously report that a cell surface and secreted protein, Meflin, is expressed in cultured MSCs, fibroblasts and pericytes, but not other types of cells including epithelial, endothelial and smooth muscle cells. We also found Meflin is a potential marker for cultured MSCs and focused on manner of Meflin with the onset of glomerulonephritis.
    We discovered that Meflin express in intersititum and around the vascular pole of glomerulus. And its’ expression increases when glomerular inflammation and fibrosis progresses.
    We also investigated the manner of Meflin positive cells with Meflin reporter mice generated in our lab.

  7. Research on diagnosis, treatment and epidemiology of membrane nephropathy in the Asia-Pacific region International coauthorship

    Grant number:16H05839  2016.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    maruyama Shoichi, Imai Enyu, Ando Masahiko

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    In order to standardize treatment for membranous nephropathy (MN), we investigated the current status of diagnosis, treatment, and epidemiology of the MN in countries of Asia and the Pacific region including Japan. The medical treatment and patient registration system of MN were very different depending on the country. The prevalence of anti-PLA2R antibody in primary MN patients was reconfirmed in Japan as low as about 50%. On the other hand, the prevalence of PLA2R antibodies in patients in China, Taiwan and Korea were all 80%, equivalent to patients in Western countries. On the contrary, the prevalence of THSD7A antibody was slightly higher in Japan than in other countries. In countries where measurement of autoantibodies cannot be performed, it was concluded that pathological staining of antigens would be the first choice. This study was able to collect a lot of information for the standardization and diffusion of future MN medical care.

  8. Drug discovery of orphan drug for congenital kidney disease using kidney visualization transparent model animal

    Grant number:16K15468  2016.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    MARUYAMA Shoichi

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    We aimed to develop a novel drug discovery platform for medicine for congenital renal disease which was based on in vivo phenotype screening using kidney-visualized-transparent-zebrafish.
    As a result, we bred a new line of transparent zebrafish that is more growth efficiency and more transparency than conventional lines. Although, the gene editing-based congenital nephrotic syndrome model lines could not be generated during study period, the congenital whole-body calcification model transparent kidney visualized line was generated using a phosphorus transporter mutant line. As a result of a compound administration experiment using frying fish, it was possible to observe dose-dependent occurrence of edema, kidney malformation, disappearance of nephron, etc. according to the nephrotoxicity of the compound. These data demonstrated the feasibility of in vivo screening system using kidney visualized transparent zebrafish.

  9. Development of biomarker for IgAN: Development of biomarker for IgAN: An international collaboration study International coauthorship

    Grant number:15H05292  2015.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Yuzawa Yukio, Jan Novak, Renfrow Matthew B., Francesco Paolo Schena

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    IgA1 with galactose (Gal)-deficient hinge-region (HR) O-glycans (Gd-IgA1) plays a key role in the pathogenesis of IgA nephropathy (IgAN). To identify potentially disease-specific IgA1 HR O-glycoforms, we profiled serum IgA1 HR glycopeptides using specimens from Japanese IgAN patients and healthy controls (HC) of different races. IgA1 from sera of 20 Japanese IgAN patients and 50 HC, recruited from Caucasian, Black, Hispanic, Asian, and Japanese populations, was purified by affinity chromatography. IgA1 HR glycosylation heterogeneity including glycan attachment sites were analyzed by liquid chromatography-high-resolution mass spectrometry. We successfully characterized HR O-glycan profile in normal subjects and identified the O-glycoforms correlating with serum level of Gd-IgA1. Identification of specific HR O-glycoforms increasing in IgAN patients will lead to the development of robust biomarker in IgAN.

  10. アジア太平洋地域における膜性腎症の実態調査研究

    Grant number:25305028  2013.4 - 2016.3

    科学研究費補助金   基板研究(B)

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    Authorship:Coinvestigator(s) 

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Industrial property rights 1

  1. 抗3’,4’ージデヒドロー3’ーデオキシシチジン抗体

    秋山真一

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    Applicant:名古屋大学

    Application no:特願2021-168946  Date applied:2021.10

 

Teaching Experience (Off-campus) 1

  1. 応用遺伝学

    2012.4 - 2013.3 Chubu University)

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    Level:Undergraduate (specialized)