研究者詳細 - アレクシッチ　ブランコ

論文 - アレクシッチ　ブランコ

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A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population 査読有り

Ito, Y; Nakamura, Y; Takahashi, N; Saito, S; Aleksic, B; Iwata, N; Inada, T; Ozaki, N

NEUROSCIENCE LETTERS 438 巻 ( 1 ) 頁： 70 - 75 2008年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Neuroscience Letters

The FXYD domain containing ion transport regulator 6 (FXYD6) gene is located within a region of chromosome 11 (11q23.3) that has been shown by a number of genome scans to be one of the most well-established linkages to schizophrenia. FXYD6 encodes the protein phosphohippolin, which is primarily expressed in the brain. Phosphohippolin modulates the kinetic activity of Na,K-ATPase and has long-term physiological importance in maintaining cation homeostasis. A recent study reported that FXYD6 was associated with schizophrenia in the United Kingdom samples. Applying the gene-based association concept, we carried out an association study regarding FXYD6 and schizophrenia in a Japanese population, with a sample consisting of 2026 subjects (906 schizophrenics and 1120 controls). After linkage disequilibrium analysis, 23 single nucleotide polymorphisms (SNPs) were genotyped using 5′-exonuclease allelic discrimination assay. We found a significant association of two SNPs (rs11216573; genotypic P value: 0.022 and rs555577; genotypic P value: 0.026, allelic P value: 0.011, uncorrected). Nominal P values did not survive correction for multiple testing (rs11216573; genotypic P value: 0.47 and rs555577; genotypic P value: 0.55, allelic P value: 0.24, after SNPSpD correction). No association was observed between schizophrenia patients and controls in allelic, genotypic and haplotypic analyses. Our findings suggest that FXYD6 is unlikely to be related to the development of schizophrenia in a Japanese population. © 2008 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.neulet.2008.04.010

Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample 査読有り

Ikeda, M; Takahashi, N; Saito, S; Aleksic, B; Watanabe, Y; Nunokawa, A; Yamanouchi, Y; Kitajima, T; Kinoshita, Y; Kishi, T; Kawashima, K; Hashimoto, R; Ujike, H; Inada, T; Someya, T; Takeda, M; Ozaki, N; Iwata, N

SCHIZOPHRENIA RESEARCH 101 巻 ( 1-3 ) 頁： 1 - 8 2008年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Schizophrenia Research

Systematic linkage disequilibrium (LD) mapping of 8p12-21 in the Icelandic population identified neuregulin 1 (NRG1) as a prime candidate gene for schizophrenia. However, results of replication studies have been inconsistent, and no large sample analyses have been reported. Therefore, we designed this study with the aim of assessing this putative association between schizophrenia and NRG1 (especially HAPICE region and exon region) using a gene-based association approach in the Japanese population. This study was a two-stage association analysis with a different panel of samples, in which the significant association found in the first-set screening samples (1126 cases and 1022 controls) was further assessed in the confirmation samples (1262 cases and 1172 controls, and 166 trio samples). In the first-set scan, 60 SNPs (49 tagging SNPs from HapMap database, four SNPs from other papers, and seven SNPs detected in the mutation scan) were examined. One haplotype showed a significant association in the first-set screening samples (Global P-value = 0.0244, uncorrected). However, we could not replicate this association in the following independent confirmation samples. Moreover, we could not find sufficient evidence for association of the haplotype identified as being significant in the first-set samples by imputing ungenotyped SNPs from HapMap database. These results indicate that the positionally and functionally attractive regions of NRG1 are unlikely to contribute to susceptibility to schizophrenia in the Japanese population. Moreover, the nature of our results support that two-stage analysis with large sample size is appropriate to examine the susceptibility genes for common diseases. © 2008 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.schres.2008.01.010

An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population. 招待有り査読有り

Saito S, Takahashi N, Maeno N, Ito Y, Aleksic B, Usui H, Iidaka T, Inada T, Ozaki N

Neuroreport 19 巻 ( 4 ) 頁： 471-3 2008年3月

An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population 査読有り国際誌

Saito Shinichi, Takahashi Nagahide, Maeno Nobuhisa, Ito Yoshihito, Aleksic Branko, Usui Hinako, Iidaka Tetsuya, Inada Toshiya, Ozaki Norio

NEUROREPORT 19 巻 ( 4 ) 頁： 471 - 473 2008年3月

Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder 査読有り

Yoshimi, A; Takahashi, N; Saito, S; Ito, Y; Aleksic, B; Usui, H; Kawamura, Y; Waki, Y; Yoshikawa, T; Kato, T; Iwata, N; Inada, T; Noda, Y; Ozaki, N

SCHIZOPHRENIA RESEARCH 100 巻 ( 1-3 ) 頁： 334 - 341 2008年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Schizophrenia Research

Several lines of evidence, including genome-wide linkage scans and postmortem brain studies of patients with schizophrenia or bipolar disorder, have suggested that DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa), a key regulatory molecule in the dopaminergic signaling pathway, is involved in these disorders. After evaluating the linkage disequilibrium pattern of the gene encoding DARPP-32 (PPP1R1B; located on 17q12), we conducted association analyses of this gene with schizophrenia and bipolar disorder. Single-marker and haplotypic analyses of four single nucleotide polymorphisms (SNPs; rs879606, rs12601930, rs907094, and rs3764352) in a sample set (subjects with schizophrenia = 384, subjects with bipolar disorder = 318, control subjects = 384) showed that PPP1R1B polymorphisms were not significantly associated with schizophrenia, whereas, even after Bonferroni corrections, significant associations with bipolar disorder were observed for rs12601930 (corrected genotypic p = 0.00059) and rs907094 (corrected allelic p = 0.040). We, however, could not confirm these results in a second independent sample set (subjects with bipolar disorder = 366, control subjects = 370). We now believe that the significant association observed with the first sample set was a result of copy number aberrations in the region surrounding these SNPs. Our findings suggest that PPP1R1B SNPs are unlikely to be related to the development of schizophrenia and bipolar disorder in the Japanese population. © 2007 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.schres.2007.10.028

An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population. 査読有り

Ji X, Takahashi N, Branko A, Ishihara R, Nagai T, Mouri A, Saito S, Maeno N, Inada T, Ozaki N

Nagoya journal of medical science 70 巻 ( 1-2 ) 頁： 11 - 7 2008年3月

Association analysis of MTHFR gene in schizophrenia 査読有り国際誌

Kawamura, Y; Takahashi, N; Saito, S; Usui, H; Yoshimi, A; Ito, Y; Branko, A; Ishihara, R; Yoshida, K; Iidaka, T; Inada, T; Iwata, N; Noda, Y; Ozaki, N

PSYCHIATRY AND CLINICAL NEUROSCIENCES 62 巻 ( 1 ) 頁： S4 - S5 2008年2月

Association Study of the Calcineurin A Gamma Subunit Gene (PPP3CC) and Methamphetamine-Use Disorder in a Japanese Population A Collaborative Study by the Japanese Genetics Initiative for Drug Abuse 査読有り国際誌

Kinoshita, Y; Ikeda, M; Ujike, H; Kitajima, T; Yamanouchi, Y; Aleksic, B; Kishi, T; Kawashima, K; Ohkouchi, T; Ozaki, N; Inada, T; Harano, M; Komiyama, T; Hori, T; Yamada, M; Sekine, Y; Iyo, M; Sora, I; Iwata, N

DRUG ADDICTION: RESEARCH FRONTIERS AND TREATMENT ADVANCES 1139 巻頁： 57 - 62 2008年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Annals of the New York Academy of Sciences

Several lines of evidence from animal and genetic analyses showed that the calcineurin A gamma subunit gene (PPP3CC) plays an important role in the pathogenesis of schizophrenia. Moreover, a recent large Japanese case-control study confirmed the genetic association of PPP3CC with schizophrenia. The symptoms of methamphetamine (MAP)-induced psychosis are similar to those of schizophrenia, suggesting that PPP3CC is an attractive candidate gene not only for schizophrenia, but also for METH-related disorders. In this study, we carried out a genetic association study of PPP3CC with MAP-use disorder in a Japanese population. We selected five haplotype-tagging SNPs from the aforementioned replication study and genotyped 393 samples (MAP abuse, 128; control, 265). We could not detect a significant association of all tagging SNPs with each condition. In conclusion, our data suggest that PPP3CC does not elevate the risk of MAP-use disorder in the Japanese population. © 2008 New York Academy of Sciences.

DOI： 10.1196/annals.1432.021

Gap junction, bipolar disorder and schizophrenia: Genetic association study 査読有り国際誌

Aleksic, B; Ikeda, M; Ishihara, R; Takahashi, N; Saito, S; Matsumoto, A; Inada, T; Idaka, T; Iwata, N; Ozaki, N

NEUROSCIENCE RESEARCH 61 巻頁： S219 - S219 2008年

Association of SOX10 with schizophrenia in the Japanese population. 招待有り査読有り

Maeno N, Takahashi N, Saito S, Ji X, Ishihara R, Aoyama N, Branko A, Miura H, Ikeda M, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Iwata N, Inada T, Ozaki N

Psychiatric genetics 17 巻 ( 4 ) 頁： 227-31 2007年8月

Association of SOX10 with schizophrenia in the Japanese population

Maeno Nobuhisa, Takahashi Nagahide, Saito Shinichi, Ji Xiaofei, Ishihara Ryoko, Aoyama Nagisa, Branko Aleksic, Miura Hideki, Ikeda Masashi, Suzuki Tatsuyo, Kitajima Tsuyoshi, Yamanouchi Yoshio, Kinoshita Yoko, Iwata Nakao, Inada Toshiya, Ozaki Norio

PSYCHIATRIC GENETICS 17 巻 ( 4 ) 頁： 227-231 2007年8月

Gap junction coding genes and schizophrenia: a genetic association study 査読有り

Aleksic, B; Ishihara, R; Takahashi, N; Maeno, N; Ji, XF; Saito, S; Inada, T; Ozaki, N

JOURNAL OF HUMAN GENETICS 52 巻 ( 6 ) 頁： 498 - 501 2007年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Human Genetics

The aim of this study was to evaluate the association of genes that encode gap junction forming proteins and schizophrenia. Representative genetic candidates (Panx2 and Cx36) from two families of gap junction genes were selected for analysis. According to the present findings these genes represent both functional and positional candidates for schizophrenia. The sample was comprised of 381 schizophrenic patients, and the same number of matched controls was tested in this study in order to evaluate the possible influence of the aforementioned genes on the pathogenesis of schizophrenia. Four SNPs in the case of Panx2 and two SNPs in the case of Cx36 were selected for analysis. Allele-, genotype- and haplotype-wise association did not yield statistically significant results. These data do not suggest that Panx2 or Cx36 could increase the risk of schizophrenia in the Japanese population. © 2007 The Japan Society of Human Genetics and Springer.

DOI： 10.1007/s10038-007-0142-5

Association study between the transferrin gene and schizophrenia in the Japanese population. 招待有り査読有り

Maeno N, Takahashi N, Saito S, Ji X, Branko A, Ishihara R, Yoshida K, Inada T, Iidaka T, Ozaki N

Neuroreport 18 巻 ( 5 ) 頁： 517-20 2007年3月

Association study between the transferrin gene and schizophrenia in the Japanese population

Maeno Nobuhisa, Takahashi Nagahide, Saito Shinichi, Ji Xiaofei, Branko Aleksic, Ishihara Ryoko, Yoshida Keizo, Inada Toshiya, Iidaka Tetsuya, Ozaki Norio

NEUROREPORT 18 巻 ( 5 ) 頁： 517-520 2007年3月

統合失調症における生物学的研究

飯高哲也, 齋藤真一, 前野信久, 尾崎紀夫

脳と精神の医学 = Brain science and mental disorders 17 巻 ( 4 ) 頁： 311 - 317 2006年12月

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