Updated on 2022/07/14

写真a

 
SATO Mitsuo
 
Organization
Graduate School of Medicine Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Professor
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 2000.9   名古屋大学 ) 

Research Interests 4

  1. 創薬開発

  2. 細胞老化

  3. 薬物治療

  4. 肺癌

Research History 6

  1. 名古屋大学大学院医学系研究科   医療技術学専攻 病態解析学講座   教授

    2018.4

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    Country:Japan

  2. 名古屋大学大学院医学系研究科   呼吸器内科学講座   准教授

    2017.10 - 2018.3

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    Country:Japan

  3. 名古屋大学医学部附属病院    呼吸器内科   講師

    2011.9

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    Country:Japan

  4. 国立長寿医療センター 呼吸器科 医長

    2008.10 - 2009.3

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    Country:Japan

  5. Assistant professor

    2007.10 - 2008.9

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    Country:Japan

  6. University of Texas Southwestern Medical Center, Hamon Ctr for Therapeutic Oncology Research, Assistant Professor

    2007.4 - 2007.9

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Education 1

  1. Nagoya University   Faculty of Medicine

    1985.4 - 1991.3

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    Country: Japan

Professional Memberships 7

  1. 日本呼吸器学会

  2. 日本内科学会

  3. 日本癌学会

  4. 日本臨床腫瘍学会

  5. 日本呼吸器内視鏡学会

  6. American Association for Cancer Research

  7. 日本アレルギー学会

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Committee Memberships 9

  1. Asian Pacific Society of Respirology (APSR)   Asian Pacific Society of Respirology (APSR); Deputy Head of Cell and Molecular Biology Assembly  

    2021.11 - 2023.10   

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    Committee type:Academic society

  2. Molecular and Clinical Oncology   Editor  

    2020.6   

  3. 香港大学 学外学位審査委員   学外学位審査委員  

    2019.6   

  4. Experimental and Therapeutic Medicine   Editor  

    2019.6   

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    Committee type:Other

  5. Cancer Cell International   Associate Editor  

    2018.11   

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    Committee type:Other

  6. 日本学術振興会 若手研究(A)細目名:呼吸器内科学    第1段審査(書面審査)委員 平成29年度  

    2016.11 - 2017.12   

  7. 日本学術振興会 基盤研究(B)細目名:呼吸器内科学    第1段審査(書面審査)委員 平成29年度  

    2016.11 - 2017.12   

  8. 日本呼吸器学会   代議員  

    2020.1   

  9. 日本癌学会   評議員  

    2020.1   

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    Committee type:Academic society

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Papers 73

  1. Hurdles for the wide implementation of photoimmunotherapy Invited Reviewed

    Kohei Matsuoka, Mitsuo Sato, Kazuhide Sato

    Immunotherapy     2021.10

  2. Spatiotemporal depletion of tumor-associated immune checkpoint PD-L1 with near-infrared Invited Reviewed

    Shunichi Taki, Kohei Matsuoka, Yuko Nishinaga, Kazuomi Takahashi, Hirotoshi Yasui, Chiaki Koike, Misae Shimizu, Mitsuo Sato, Kazuhide Sato

    Journal for ImmunoTherapy of Cancer     2021.10

  3. Oxytocin receptor is a promising therapeutic target of malignant mesothelioma Invited Reviewed

    Yuta Kodama, Ichidai Tanaka, Tatsuhiro Sato, Kazumi Hori, Soei Gen, Masahiro Morise, Daisuke Matsubara, Mitsuo Sato, Yoshitaka Sekido, Naozumi Hashimoto

    Cancer Science     2021.9

  4. (Review article) Immortalized normal human lung epithelial cell models for studying lung cancer biology Reviewed

    Mitsuo Sato, Jerry W. Shay, John D. Minna

    Respiratory Investigation   Vol. 0000 ( 0000 ) page: 0000   2020.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  5. UHRF1, a regulator of methylation, as a diagnostic and prognostic marker for lung cancer Reviewed

    Daiki Goto, Kazuki Komeda, Natsuki Uwatoko, Moeka Nakashima, Mayu Koike, Kaho Kawai, Yuta Kodama, Ayako Miyazawa, Ichidai Tanaka, Tetsunari Hase, Masahiro Morise, Yoshinori Hasegawa, Tsutomu Kawabe, Mitsuo Sato (corresponding author)

    Cancer Investigation   Vol. 38   page: 240-249   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/07357907.2020

  6. Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer. Reviewed

    Shimizu T, Okachi S, Imai N, Hase T, Morise M, Hashimoto N, Sato M, Hasegawa Y

    Nagoya J Med Sci   Vol. 82   page: 69-77   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  7. (Review article) Phenotypic screening with large-scale genomic libraries to discover drug targets for cancer Reviewed

    Mitsuo Sato

    Oncology Letters     page: In Press   2020.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: In Press

  8. (Editorial) Chemotherapy induced changes to fibrin clots properties in lung cancer:Is it favorable?

    Mitsuo Sato

    Journal of Thoracic Disease     page: In press   2019.5

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    Authorship:Lead author   Language:English  

    DOI: 00000

  9. Exploration of germline variants responsible for adverse events of crizotinib in anaplastic lymphoma kinase-positive non-small cell lung cancer by target-gene panel sequencing. Reviewed

    Mizugaki H, Hamada A, Shibata T, Hosoda F, Nakamura H, Okuma Y, Shukuya T, Umemura S, Horiike A, Fukui T, Kogure Y, Daga H, Urata Y, Yamada K, Saeki S, Fujisaka Y, Nakamura Y, Sato M, Yoshida T, Hotta T, Oizumi S, Fujiwara Y, Ohe Y, Fujiwara Y.

    Lung Cancer   Vol. 128   page: 20-25   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lungcan

  10. A 65-nm CMOS Fully Integrated Analysis Platform Using an On-Chip Vector Network Analyzer and a Transmission-Line-Based Detection Window for Analyzing Circulating Tumor Cell and Exosome. Reviewed

    Niitsu K, Nakanishi T, Murakami S, Matsunaga M, Kobayashi A, Karim NM, Ito J, Ozawa N, Hase T, Tanaka H, Sato M, Kondo H, Ishikawa K, Odaka H, Hasegawa Y, Hori M, Nakazato K.

    IEEE Trans Biomed Circuits Syst.   Vol. 13   page: 470-479.   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1109/TBCAS.2018.2882472.

  11. Potential for afatinib as an optimal treatment for advanced non-small cell lung carcinoma in patients with uncommon EGFR mutations. Reviewed

    Tanaka I, Morise M, Kodama Y, Matsui A, Ozawa N, Ozone S, Goto D, Miyazawa A, Hase T, Hashimoto N, Sato M, Hasegawa Y

    Lung Cancer.   Vol. 127   page: 169-171   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lungcan.

  12. (Editorial) Specific Copy Number Changes as Potential Predictive Markers for Adjuvant Chemotherapy in Non-Small Cell Lung Cancer Invited Reviewed

    Mitsuo Sato

    Translational Lung Cancer Research     page: In press   2018.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: In press

  13. An EGFR-mutated Lung Adenocarcinoma Undergoing Squamous Cell Carcinoma Transformation Exhibited a Durable Response to Afatinib. Reviewed

    Sato M, Matsui A, Shimoyama Y, Omote N, Morise M, Hase T, Tanaka I, Suzuki K, Hasegawa Y.

    Intern Med.     2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.0999-18.

  14. Pseudomembranous Invasive Tracheobronchial Aspergillosis with Fulminant Hepatitis and Hemophagocytic Syndrome. Reviewed

    Majima S, Okachi S, Asano M, Wakahara K, Hashimoto N, Sato M, Ishigami M, Hasegawa Y.

    Intern Med.   Vol. 57   page: 2371-2375   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.9673-17

  15. eIF2β, a Subunit of Translation-Initiation Factor EIF2, Is a Potential Therapeutic Target for Non-Small Cell Lung Cancer.

    Tanaka I, Sato M (corresponding author), Kato T, Goto D, Kakumu T, Miyazawa A, Yogo N, Hase T, Morise M, Sekido Y, Girard L, Minna JD, Byers LA, Heymach JV, Coombes KR, Kondo M, Hasegawa Y.

    Cancer Sci.     page: 10.1111/cas.13602.   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13602.

  16. Safety and efficacy of diagnostic flexible bronchoscopy in very old patients with lung cancer Reviewed

    Shotaro Okachi, Kazuyoshi Imaizumi, Naoyuki Imai, Takahiro Shimizu, Tetsunari Hase, Masahiro Morise, Naozumi Hashimoto, Mitsuo Sato, Yoshinori Hasegawa

    European Geriatric Medicine   Vol. 9   page: 255-262   2018.2

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  17. Lung Metastases from Bile Duct Adenocarcinoma Mimicking Chronic Airway Infection and Causing Diagnostic Difficulty.

    Sato M, Okachi S, Fukihara J, Shimoyama Y, Wakahara K, Sakakibara T, Hase T, Onishi Y, Ogura Y, Maeda O, Hasegawa Y.

    Intern Med.     page: 10.2169/internalmedicine.9718-17.   2017.12

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    DOI: 10.2169/internalmedicine.9718-17.

  18. Regulation of PD-L1 expression by matrix stiffness in lung cancer cells. Reviewed

    Miyazawa A, Ito S, Asano S, Tanaka I, Sato M, Kondo M, Hasegawa Y

    Biochemical and biophysical research communications     2017.12

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    DOI: 10.1016/j.bbrc.2017.12.115

    PubMed

  19. Identification of proteasomal catalytic subunit PSMA6 as a therapeutic target for lung cancer. Reviewed

    Kakumu T, Sato M (corresponding author), Goto D, Kato T, Yogo N, Hase T, Morise M, Fukui T, Yokoi K, Sekido Y, Girard L, Minna JD, Byers LA, Heymach JV6, Coombes KR, Kondo M, Hasegawa Y

    Cancer Sci.   Vol. 108   page: 732-743   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13185.

  20. ZEB1 drives epithelial-to-mesenchymal transition in lung cancer. Reviewed

    Larsen JE, Nathan V, Osborne JK, Farrow RK, Deb D, Sullivan JP, Dospoy PD, Augustyn A, Hight SK, Sato M, Girard L, Behrens C, Wistuba II, Gazdar AF, Hayward NK, Minna JD.

    J Clin Invest.     2016.8

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    DOI: doi: 10.1172/JCI76725.

  21. Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis. Reviewed

      Vol. 10   page: e0134842   2015.8

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    DOI: 10.1371/journal.pone.0134842.

  22. Growth inhibitory effects of miR-221 and miR-222 in non-small cell lung cancer cells. Reviewed

    Yamashita R, Sato M, Kakumu T, Hase T, Yogo N, Maruyama E, Sekido Y, Kondo M, Hasegawa Y.

    Cancer Med.   Vol. 4   page: 551-564   2015.4

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    DOI: 10.1002/cam4.412.

  23. Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Reviewed

    Sato M, Larsen JE, Lee W, Sun H, Shames DS, Dalvi MP, Ramirez RD, Tang H, Dimaio JM, Gao B, Xie Y, Wistuba II, Gazdar AF, Shay JW, Minna JD.

        page: Epub ahead of print   2013

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  24. Primary prophylaxis indication for docetaxel induced febrile neutropenia in elderly patients with non-small cell lung cancer

    Akira Matsui;Masahiro Morise;Ichidai Tanaka;Sachiko Ozone;Reiko Matsuzawa;Junji Koyama;Tetsunari Hase;Naozumi Hashimoto;Mitsuo Sato;Yoshinori Hasegawa

    Cancer Investigation   Vol. In press ( In press ) page: 1-19   2020.8

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  25. Exploration of germline variants responsible for adverse events of crizotinib in anaplastic lymphoma kinase-positive non-small cell lung cancer by target-gene panel sequencing. Reviewed

    Mizugaki H, Hamada A, Shibata T, Hosoda F, Nakamura H, Okuma Y, Shukuya T, Umemura S, Horiike A, Fukui T, Kogure Y, Daga H, Urata Y, Yamada K, Saeki S, Fujisaka Y, Nakamura Y, Sato M, Yoshida T, Hotta T, Oizumi S, Fujiwara Y, Ohe Y, Fujiwara Y.

    Lung Cancer.   Vol. 128   page: 20-25   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lungcan.2018.12.002

  26. NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM. Reviewed

    Osborne JK, Larsen JE, Shields MD, Gonzales JX, Shames DS, Sato M, Kulkarni A, Wistuba II, Girard L, Minna JD, Cobb MH.

    Proc Natl Acad Sci U S A.   Vol. 110 ( 16 ) page: 6524-9   2013

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    DOI: 10.1073/pnas.1303932110.

  27. (Review article) Emerging evidence of Epithelial-to-Mesenchymal Transition in lung carcinogenesis. Invited Reviewed

    Sato M, Shames DS, Hasegawa Y.

    Respirology.     2012

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    DOI: 10.1111/j.1440-1843.2012.02173.x. [Epub ahead of print]

  28. Nongenomic effects of fluticasone propionate and budesonide on human airway anion secretion. Reviewed

    Mizutani T, Morise M, Ito Y, Hibino Y, Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, Hasegawa Y.

    Am J Respir Cell Mol Biol   Vol. 47   page: 645   2012

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  29. Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer. Reviewed

    Sunaga N, Kaira K, Imai H, Shimizu K, Nakano T, Shames DS, Girard L, Soh J, Sato M, Iwasaki Y, Ishizuka T, Gazdar AF, Minna JD, Mori M.

    Oncogene.     page: 10.1038/onc   2012

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  30. NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition. Reviewed

    Osborne JK, Larsen JE, Gonzales JX, Shames DS, Sato M, Wistuba II, Girard L, Minna JD, Cobb MH.

    Oncogenesis     2013

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    DOI: 10.1038/oncsis.2013.24.

  31. The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma. Reviewed

    Elshazley M, Sato M, Hase T, Yamashita R, Yoshida K, Toyokuni S, Ishiguro F, Osada H, Sekido Y, Yokoi K, Usami N, Shames DS, Kondo M, Gazdar AF, Minna JD, Hasegawa Y.

    Int J Cancer.     2012

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    DOI: 10.1002/ijc.27598. [Epub ahead of print]

  32. Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer. Reviewed

    Sunaga N, Imai H, Shimizu K, Shames DS, Kakegawa S, Girard L, Sato M, Kaira K, Ishizuka T, Gazdar AF, Minna JD, Mori M.

    Int J Cancer.   Vol. 130   page: 1733   2012

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  33. STIM1 regulates platelet-derived growth factor-induced migration and Ca2+ influx in human airway smooth muscle cells. Reviewed

    Suganuma N, Ito S, Aso H, Kondo M, Sato M, Sokabe M, Hasegawa Y.

    PLoS One   Vol. 7   page: e45056   2012

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  34. Echoic features of lymph nodes with sarcoidosis determined by endobronchial ultrasound. Reviewed

    Imai N, Imaizumi K, Ando M, Shimokata T, Ogawa T, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y.

    Intern Med.   Vol. 52 ( 13 ) page: 1473-8   2013

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  35. Capsaicinoids regulate airway anion transporters through Rho kinase- and cyclic AMP-dependent mechanisms.

    Hibino Y, Morise M, Ito Y, Mizutani T, Matsuno T, Ito S, Hashimoto N, Sato M, Kondo M, Imaizumi K, Hasegawa Y.

    Am J Respir Cell Mol Biol   Vol. 45   page: 684   2011

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  36. Pivotal role of epithelial cell adhesion molecule in the survival of lung cancer cells. Reviewed

    Hase T, Sato M, Yoshida K, Girard L, Takeyama Y, Horio M, Elshazley M, Oguri T, Sekido Y, Shames DS, Gazdar AF, Minna JD, Kondo M, Hasegawa Y.

    Cancer Sci.   Vol. 102   page: 1493   2011

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  37. Pleural plaque profiles on the chest radiographs and CT scans of asbestos-exposed Japanese construction workers. Reviewed

    Elshazley M, Shibata E, Hisanaga N, Ichihara G, Ewis AA, Kamijima M, Ichihara S, Sakai K, Sato M, Kondo M, Hasegawa Y.

    Ind Health   Vol. 49   page: 626   2011

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  38. Aqueous fraction of Sauropus androgynus might be responsible for bronchiolitis obliterans. Reviewed

    Hashimoto I, Imaizumi K, Hashimoto N, Furukawa H, Noda Y, Kawabe T, Honda T, Ogawa T, Matsuo M, Imai N, Ito S, Sato M, Kondo M, Shimokata K, Hasegawa Y.

    Respirology   Vol. 18   page: 340   2013

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  39. Transient but Not Stable ZEB1 Knockdown Dramatically Inhibits Growth of Malignant Pleural Mesothelioma Cells. Reviewed

    Horio M, Sato M, Takeyama Y, Elshazley M, Yamashita R, Hase T, Yoshida K, Usami N, Yokoi K, Sekido Y, Kondo M, Toyokuni S, Gazdar AF, Minna JD, Hasegawa Y.

    Ann Surg Oncol.     2011

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    DOI: 10.1245/s10434-011-2142-0

  40. Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy. Reviewed

    Sunaga N, Shames DS, Girard L, Peyton M, Larsen JE, Imai H, Soh J, Sato M, Yanagitani N, Kaira K, Xie Y, Gazdar AF, Mori M, Minna JD.

    Mol Cancer Ther.   Vol. 10   page: 336   2011

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  41. TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival. Reviewed

    Yoshida K, Sato M, Hase T, Elshazley M, Yamashita R, Usami N, Taniguchi T, Yokoi K, Nakamura S, Kondo M, Girard L, Minna JD, Hasegawa Y.

    Cancer Sci.     2013

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    DOI: 10.1111/cas.12068.

  42. Knockdown of ZEB1, a master epithelial-to-mesenchymal transition (EMT) gene, suppresses anchorage-independent cell growth of lung cancer cells. Reviewed

    Takeyama Y, Sato M, Horio M, Hase T, Yoshida K, Yokoyama T, Nakashima H, Hashimoto N, Sekido Y, Gazdar AF, Minna JD, Kondo M, Hasegawa Y.

    Cancer letters   Vol. 296   page: 216-224   2010.10

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  43. Associations between oxaliplatin-induced peripheral neuropathy and polymorphisms of the ERCC1 and GSTP1 genes. Reviewed

    Int J Clin Pharmacol Ther.   Vol. 48   page: 729-34   2010

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  44. Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. Reviewed

    Kwei, K.A., Kim, Y.H., Girard, L., Kao, J., Pacyna-Gengelbach, M., Salari, K., Lee, J., Choi, Y.L., Sato, M., Wang, P., Hernandez-Boussard, T., Gazdar, A.F., Petersen, I., Minna, J.D. & Pollack, J.R.

    Oncogene   Vol. 27   page: 3635-40   2008

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  45. EGFR-TKI resistance due to BIM polymorphism can be circumvented by in combination with HDAC inhibition. Reviewed

    Nakagawa T, Takeuchi S, Yamada T, Ebi H, Sano T, Nanjo S, Ishikawa D, Sato M, Hasegawa Y, Sekido Y, Yano S.

    Cancer Res     page: Epub ahead of print]   2013

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  46. PIK3CA mutations and copy number gains in human lung cancers. 68, 6913-21, 2008. Reviewed

      Vol. 68   page: 6913-21   2008

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  47. Endobronchial ultrasound transbronchial needle aspiration in older people. Reviewed

    Okachi S, Imai N, Imaizumi K, Hase T, Shindo Y, Sakamoto K, Aso H, Wakahara K, Hashimoto I, Ito S, Hashimoto N, Sato M, Kondo M, Hasegawa Y.

    Geriatr Gerontol Int     page: 10.1111/ggi   2013

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    DOI: 10.1111/ggi

  48. Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Reviewed

    Iwanaga, K., Yang, Y., Raso, M.G., Ma, L., Hanna, A.E., Thilaganathan, N., Moghaddam, S., Evans, C.M., Li, H., Cai, W.W., Sato, M., Minna, J.D., Wu, H., Creighton, C.J., Demayo, F.J., Wistuba, II & Kurie, J.M.

    Cancer Res   Vol. 68   page: 1119-27   2008

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  49. Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells. Reviewed

    Nakashima H, Hashimoto N, Aoyama D, Kohnoh T, Sakamoto K, Kusunose M, Imaizumi K, Takeyama Y, Sato M, Kawabe T, Hasegawa Y.

    Mol Carcinog   Vol. 51   page: 400   2012

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  50. Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. Reviewed

    Guha, U., Chaerkady, R., Marimuthu, A., Patterson, A.S., Kashyap, M.K., Harsha, H.C., Sato, M., Bader, J.S., Lash, A.E., Minna, J.D., Pandey, A. & Varmus, H.E.

    Proc Natl Acad Sci U S A   Vol. 105   page: 14112-7   2008

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  51. Characterizing the cancer genome in lung adenocarcinoma. Reviewed

    Weir, B.A., Woo, M.S., Getz, G., Perner, S., Ding, L., Beroukhim, R., Lin, W.M., Province, M.A., Kraja, A., Johnson, L.A., Shah, K., Sato, M., Thomas, R.K., Barletta, J.A., Borecki, I.B., Broderick, S., Chang, A.C., Chiang, D.Y., Chirieac, L.R., Cho, J., Fujii, Y., Gazdar, A.F., Giordano, T., Greulich, H., Hanna, M., Johnson, B.E., Kris, M.G., Lash, A., Lin, L., Lindeman, N., Mardis, E.R., McPherson, J.D., Minna, J.D., Morgan, M.B., Nadel, M., Orringer, M.B., Osborne, J.R., Ozenberger, B., Ramos, A.H., Robinson, J., Roth, J.A., Rusch, V., Sasaki, H., Shepherd, F., Sougnez, C., Spitz, M.R., Tsao, M.S., Twomey, D., Verhaak, R.G., Weinstock, G.M., Wheeler, D.A., Winckler, W., Yoshizawa, A., Yu, S., Zakowski, M.F., Zhang, Q., Beer, D.G., Wistuba, II, Watson, M.A., Garraway, L.A., Ladanyi, M., Travis, W.D., Pao, W., Rubin, M.A., Gabriel, S.B., Gibbs, R.A., Varmus, H.E., Wilson, R.K., Lander, E.S. & Meyerson, M.

    Nature   Vol. 450   page: 893-8   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

  52. (Review article) A translational view of the molecular pathogenesis of lung cancer. Invited Reviewed

    Sato, M., Shames, D.S., Gazdar, A.F. & Minna, J.D.

    J Thorac Oncol   Vol. 2   page: 327-43   2007

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  53. Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized. Reviewed

    Padron, D., Sato, M., Shay, J.W., Gazdar, A.F., Minna, J.D. & Roth, M.G.

    Cancer Res   Vol. 67   page: 7695-702   2007

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  54. EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Reviewed

    Vikis, H., Sato, M. (equal contribution), James, M., Wang, D., Wang, Y., Wang, M., Jia, D., Liu, Y., Bailey-Wilson, J.E., Amos, C.I., Pinney, S.M., Petersen, G.M., de Andrade, M., Yang, P., Wiest, J.S., Fain, P.R., Schwartz, A.G., Gazdar, A., Gaba, C., Rothschild, H., Mandal, D., Kupert, E., Seminara, D., Viswanathan, A., Govindan, R., Minna, J., Anderson, M.W. & You, M.

    Cancer Res   Vol. 67   page: 4665-70   2007

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  55. EGFR signaling is required for TGF-beta 1 mediated COX-2 induction in human bronchial epithelial cells. Reviewed

    Liu, M., Yang, S.C., Sharma, S., Luo, J., Cui, X., Peebles, K.A., Huang, M., Sato, M., Ramirez, R.D., Shay, J.W., Minna, J.D. & Dubinett, S.M.

    Am J Respir Cell Mol Biol   Vol. 37   page: 578-88   2007

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  56. Silencing of HPV 18 oncoproteins With RNA interference causes growth inhibition of cervical cancer cells. Reviewed

    Lea, J.S., Sunaga, N., Sato, M., Kalahasti, G., Miller, D.S., Minna, J.D. & Muller, C.Y.

    Reprod Sci   Vol. 14,   page: 20-8   2007

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  57. Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma. Reviewed

    Das, A.K., Chen, B.P., Story, M.D., Sato, M., Minna, J.D., Chen, D.J. & Nirodi, C.S.

    Cancer Res   Vol. 67   page: 5267-74   2007

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  58. High Expression of Ligands for Chemokine Receptor CXCR2 in Alveolar Epithelial Neoplasia Induced by Oncogenic Kras. Reviewed

    Wislez, M., Fujimoto, N., Izzo, J.G., Hanna, A.E., Cody, D.D., Langley, R.R., Tang, H., Burdick, M.D., Sato, M., Minna, J.D., Mao, L., Wistuba, I., Strieter, R.M. & Kurie, J.M.

    Cancer Res   Vol. 66   page: 4198-4207   2006

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  59. A genome-wide screen for pormoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. Reviewed

    Shames, D.S., Girard, L., Gao, B., Sato, M., Lewis, C.M., Shivapurkar, N., Jiang, A., Perou, C.M., Kim, Y.H., Pollack, J.R., Fong, K.M., Lam, C., Wong, M., Shyr, Y., Nanda, R., Olopade, O.I., Gerald, W., Euhus, D.M., Shay, J.W., Gazdar, A.F. & Minna, J.D.

    PLOS medicine   Vol. 3   page: e486   2006

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  60. Non-Small Cell Lung Cancers with Kinase Domain Mutations in the Epidermal Growth Factor Receptor Are Sensitive to Ionizing Radiation. Reviewed

    Das, A.K., Sato, M., Story, M.D., Peyton, M., Graves, R., Redpath, S., Girard, L., Gazdar, A.F., Shay, J.W., Minna, J.D. & Nirodi, C.S.

    Cancer Res   Vol. 66   page: 9601-9608   2006

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  61. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Reviewed

    Sato, M., Vaughan, M.B., Girard, L., Peyton, M., Lee, W., Shames, D.S., Ramirez, R.D., Sunaga, N., Gazdar, A.F., Shay, J.W. & Minna, J.D.

    Cancer Res   Vol. 66   page: 2116-28   2006

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  62. The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer. Reviewed

    Sekine, I., Sato, M., Sunaga, N., Toyooka, S., Peyton, M., Parsons, R., Wang, W., Gazdar, A.F. & Minna, J.D.

    Oncogene   Vol. 24   page: 2735-8   2005

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  63. High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Reviewed

    Fujimoto, N., Wislez, M., Zhang, J., Iwanaga, K., Dackor, J., Hanna, A.E., Kalyankrishna, S., Cody, D.D., Price, R.E., Sato, M., Shay, J.W., Minna, J.D., Peyton, M., Tang, X., Massarelli, E., Herbst, R., Threadgill, D.W., Wistuba, II & Kurie, J.M.

    Cancer Res   Vol. 65   page: 11478-85   2005

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  64. Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Reviewed

    Sunaga, N., Miyajima, K., Suzuki, M., Sato, M., White, M.A., Ramirez, R.D., Shay, J.W., Gazdar, A.F. & Minna, J.D.

    Cancer Res   Vol. 64   page: 4277-85   2004

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  65. Pulmonary cryptococcosis with a solitary focal ground-glass opacity on high-resolution computed tomography. Reviewed

    Sato, M., Okamoto, M., Takagi, Y., Ikeda, T., Niimi, T., Fukatsu, E., Maruyama, K., Nara, Y., Shimokata, K. & Hasegawa, Y.

    Intern Med   Vol. 43   page: 117-9   2004

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  66. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Reviewed

    Ramirez, R.D., Sheridan, S., Girard, L., Sato, M., Kim, Y., Pollack, J., Peyton, M., Zou, Y., Kurie, J.M., Dimaio, J.M., Milchgrub, S., Smith, A.L., Souza, R.F., Gilbey, L., Zhang, X., Gandia, K., Vaughan, M.B., Wright, W.E., Gazdar, A.F., Shay, J.W. & Minna, J.D.

    Cancer Res   Vol. 64   page: 9027-34   2004

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  67. Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer. Reviewed

    Sato, M., Girard, L., Sekine, I., Sunaga, N., Ramirez, R.D., Kamibayashi, C. & Minna, J.D.

    Oncogene   Vol. 22   page: 7243-6   2003

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  68. Establishment of a large cell lung cancer cell line (Y-ML-1B) producing granulocyte colony-stimulating factor. Reviewed

    Sekido, Y., Sato, M., Usami, N., Shigemitsu, K., Mori, S., Maeda, O., Yokoi, T., Hasegawa, Y., Yoshioka, H. & Shimokata, K.

    Cancer Genet Cytogenet   Vol. 137   page: 33-42   2002

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  69. The expression of DNA methyltransferases and methyl-CpG-binding proteins is not associated with the methylation status of p14(ARF), p16(INK4a) and RASSF1A in human lung cancer cell lines. Reviewed

    Sato, M., Horio, Y., Sekido, Y., Minna, J.D., Shimokata, K. & Hasegawa, Y.

    Oncogene   Vol. 21   page: 4822-9   2002

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  70. Genetic alteration of the beta-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion. Reviewed

    Shigemitsu, K., Sekido, Y., Usami, N., Mori, S., Sato, M., Horio, Y., Hasegawa, Y., Bader, S.A., Gazdar, A.F., Minna, J.D., Hida, T., Yoshioka, H., Imaizumi, M., Ueda, Y., Takahashi, M. & Shimokata, K.

    Oncogene   Vol. 20   page: 4249-57   2001

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  71. Autologous blood-patch pleurodesis for secondary spontaneous pneumothorax with persistent air leak. Reviewed

    Ando, M., Yamamoto, M., Kitagawa, C., Kumazawa, A., Sato, M., Shima, K., Watanabe, A., Shimokata, K. & Hasegawa, Y.

    Respir Med   Vol. 93   page: 432-4   1999

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  72. Phase I/II and pharmacologic study of irinotecan and carboplatin for patients with lung cancer. Reviewed

    Sato, M., Ando, M., Minami, H., Ando, Y., Yamamoto, M., Sakai, S., Watanabe, A., Ikeda, T., Sekido, Y., Saka, H., Shimokata, K. & Hasegawa, Y.

    Cancer Chemother Pharmacol   Vol. 48   page: 481-7   2001

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  73. Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer. Reviewed

    Sato, M., Sekido, Y., Horio, Y., Takahashi, M., Saito, H., Minna, J.D., Shimokata, K. & Hasegawa, Y.

    Jpn J Cancer Res   Vol. 91   page: 504-9   2000

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Books 4

  1. Micro RNA in Regenerative Medicine

    Mitsuo Sato, David S. Shames, Yoshinori Hasegawa( Role: Joint author)

    Elsevier  2014.12 

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    Language:English

  2. The Molecular Genetics of Lung Cancer. In: Jack. A Roth, Waun Ki. Hong, and James D. Cox (eds.) Lung Cancer. 3rd edition.

    Shames, D.S., Sato, M. & Minna, J.D.( Role: Joint author)

    Blackwell Publishing  2007 

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    Language:English

  3. Molecular Genetics of Lung Cancer. In: J. Mendelsohn, P. M. Howley, M. A. Israel, J. Gray, and C. B. Thompson (eds.), The Molecular Basis of Cancer. 3rd edition.

    Sato, M., Shames, D.S., Girard, L., Gazdar, A.F. & Minna, J.D.( Role: Joint author)

    Elsevier Press  2007 

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    Language:English

  4. 抗悪性腫瘍薬コンサルトブック 改訂第2版

    佐藤光夫( Role: Contributor)

    南江堂  2017.8 

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    Total pages:430   Language:Japanese

Research Project for Joint Research, Competitive Funding, etc. 7

  1. Developing a novel synthetic lethal treatment with long non-coding RNA (lncRNA) for KRAS-mutated lung cancer

    2022.4 - 2024.3

    The Asian Pacific Society of Respirology Assembly Fund Project Grant 

    Dr Mitsuo Sato (Japan) Principal team members: Dr Ichidai Tanaka (Japan) Dr Kazuhide Sato (Japan)

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    Authorship:Principal investigator  Grant type:Other

    Grant amount:\1297800 ( Direct Cost: \1245888 、 Indirect Cost:\51912 )

  2. 変異KRAS肺癌に対する長鎖非翻訳RNAを標的とする合成致死治療の開発

    2022.4 - 2023.3

    がん研究助成金(課題:A) 

    佐藤 光夫

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    Grant amount:\1000000

  3. トランスポゾンベクターによる長鎖非翻訳RNAの機能評価を活用した変異KRAS肺癌の合成致死

    2022.4 - 2023.3

    第47回がんその他の悪性新生物研究助成金 

    佐藤光夫

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    Grant amount:\250000

  4. 細胞老化の誘導を利用した変異KRAS癌の創薬研究

    2020.4 - 2021.3

    「橋渡し研究戦略的推進プログラム」研究費支援シーズA 

    佐藤 光夫

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    Grant type:Competitive

  5. 細胞老化の誘導を利用した変異KRAS癌の創薬研究

    2019.4 - 2020.3

    平成31年度「橋渡し研究戦略的推進プログラム」研究費支援シーズA 

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    Grant type:Competitive

  6. 上皮間養系細胞転換(EMT)の安定化因子を標的とする肺がん治療開発

    2018.8 - 2019.3

    第43回(平成30年度)がんその他の悪性新生物研究助成金 

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    Grant type:Competitive

  7. 細胞老化を利用した変異型KRAS肺癌の新規治療薬開発

    2018.2

    国内共同研究 

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KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. 長鎖非翻訳RNAを標的とする変異KRAS肺癌の合成致死治療の開発

    Grant number:22K19522  2022.6 - 2024.3

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

    佐藤光夫、田中一大

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

  2. ドライバー癌遺伝子誘導性の細胞老化を作用機序とする変異KRAS肺癌の創薬研究

    Grant number:21H02924  2021.4 - 2023.3

    科学研究費補助金   基盤研究(B)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

  3. 部分的上皮間葉細胞転換(ハイブリッドEMT)の安定化因子を標的とする肺癌治療

    2019.6 - 2021.3

    科学研究費補助金  挑戦的研究(萌芽)

    佐藤 光夫

  4. ドライバー癌遺伝子により誘導される細胞老化 (OIS) を利用した肺癌治療の開発

    2018.4 - 2021.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  5. アノイキス抵抗性に基づいた網羅的な肺癌ドライバー遺伝子特定の研究

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  6. クラスター形成関連分子を標的としたEGFR変異肺癌の転移抑制治療の開発

    2014.4 - 2016.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  7. 肺癌の上皮間葉細胞転換原因遺伝子と新規治療標的の探索研究

    2011.4 - 2014.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  8. 肺がん治療標的としての上皮間葉系細胞転換(EMT)関連分子同定の研究    

    2008.4 - 2011.3

    科学研究費補助金  基盤研究(C)

    佐藤 光夫

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    Authorship:Principal investigator 

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