2022/10/31 更新

写真a

ヒシダ アサヒ
菱田 朝陽
HISHIDA, Asahi
所属
大学院医学系研究科 総合医学専攻 社会生命科学 准教授
大学院担当
大学院医学系研究科
学部担当
医学部 医学科
職名
准教授

学位 3

  1. M.P.H. ( 2012年5月 ) 

  2. 博士(医学) ( 2005年3月   名古屋大学 ) 

  3. M.D. ( 1998年3月   Nagoya University ) 

研究キーワード 2

  1. 遺伝子環境交互作用

  2. がん分子疫学

研究分野 2

  1. ライフサイエンス / 医療管理学、医療系社会学

  2. ライフサイエンス / 医療管理学、医療系社会学

現在の研究課題とSDGs 1

  1. がん分子疫学

経歴 1

  1. 名古屋大学   大学院医学系研究科 総合医学専攻 社会生命科学   准教授

    2020年1月 - 現在

学歴 3

  1. University of North Carolina at Chapel Hill   Department of Epidemiology

    - 2012年5月

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    国名: アメリカ合衆国

  2. 名古屋大学   医学系研究科

    - 2005年3月

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    国名: 日本国

  3. 名古屋大学   医学部

    - 1998年3月

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    国名: 日本国

 

論文 216

  1. A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern.

    Suzuki H, Nakamura Y, Matsuo K, Imaeda N, Goto C, Narita A, Shimizu A, Takashima N, Matsui K, Miura K, Nakatochi M, Hishida A, Tamura T, Kadomatsu Y, Okada R, Nishida Y, Shimanoe C, Nishimoto D, Takezaki T, Oze I, Ito H, Ikezaki H, Murata M, Matsui D, Ozaki E, Mikami H, Nakamura Y, Suzuki S, Watanabe M, Arisawa K, Uemura H, Kuriki K, Momozawa Y, Kubo M, Kita Y, Takeuchi K, Wakai K

    European journal of clinical nutrition   75 巻 ( 6 ) 頁: 937 - 945   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:European Journal of Clinical Nutrition  

    DOI: 10.1038/s41430-020-00823-z

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  2. An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate.

    Nakatochi M, Toyoda Y, Kanai M, Nakayama A, Kawamura Y, Hishida A, Mikami H, Matsuo K, Takezaki T, Momozawa Y, Biobank Japan Project., Kamatani Y, Ichihara S, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H, Japan Uric Acid Genomics Consortium (Japan Urate).

    Rheumatology (Oxford, England)     2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/rheumatology/keab404

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  3. Association of self-reported moderate vegetable juice intake with small decline in kidney function in a five-year prospective study.

    Fujii R, Kondo T, Tsukamoto M, Kawai S, Sasakabe T, Naito M, Kubo Y, Okada R, Tamura T, Hishida A, Ueyama J, Hayashi Y, Ohnishi J, Hamajima N, Takeuchi K, Wakai K

    Nutrition (Burbank, Los Angeles County, Calif.)   84 巻   頁: 111114   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nutrition  

    DOI: 10.1016/j.nut.2020.111114

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  4. Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.

    Kawaguchi M, Nakayama A, Aoyagi Y, Nakamura T, Shimizu S, Kawamura Y, Takao M, Tamura T, Hishida A, Nagayoshi M, Nagase M, Ooyama K, Ooyama H, Shinomiya N, Matsuo H

    Human cell   34 巻 ( 2 ) 頁: 293 - 299   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Human Cell  

    DOI: 10.1007/s13577-021-00485-4

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  5. A genome-wide association study on fish consumption in a Japanese population—the Japan Multi-Institutional Collaborative Cohort study

    Suzuki T.

    European Journal of Clinical Nutrition   75 巻 ( 3 ) 頁: 480 - 488   2021年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:European Journal of Clinical Nutrition  

    DOI: 10.1038/s41430-020-00702-7

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  6. Assessing the relationship between high-sensitivity C-reactive protein and kidney function employing mendelian randomization in a Japanese community based J-MICC Study.

    Fujii R, Hishida A, Nishiyama T, Nakatochi M, Matsuo K, Ito H, Nishida Y, Shimanoe C, Nakamura Y, Turin TC, Suzuki S, Watanabe M, Ibusuki R, Takezaki T, Mikami H, Nakamura Y, Ikezaki H, Murata M, Kuriki K, Kuriyama N, Matsui D, Arisawa K, Katsuura-Kamano S, Tsukamoto M, Tamura T, Kubo Y, Kondo T, Momozawa Y, Kubo M, Takeuchi K, Wakai K

    Journal of epidemiology     2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2188/jea.JE20200540

    PubMed

  7. Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study.

    Hishida A, Nakatochi M, Tamura T, Nagayoshi M, Okada R, Kubo Y, Tsukamoto M, Kadomatsu Y, Suzuki S, Nishiyama T, Kuriyama N, Watanabe I, Takezaki T, Nishimoto D, Kuriki K, Arisawa K, Katsuura-Kamano S, Mikami H, Kusakabe M, Oze I, Koyanagi YN, Nakamura Y, Kadota A, Shimanoe C, Tanaka K, Ikezaki H, Murata M, Kubo M, Momozawa Y, Takeuchi K, Wakai K, for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.

    Nagoya journal of medical science   83 巻 ( 1 ) 頁: 183 - 194   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

    DOI: 10.18999/nagjms.83.1.183

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  8. Green tea consumption and the risk of colorectal cancers in Japanese - data from the JACC Study

    Hishida Asahi, Wakai Kenji, Tamakoshi Akiko

    CANCER SCIENCE   112 巻   頁: 586 - 586   2021年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  9. Cost-Effectiveness of Behavior Modification Intervention for Patients With Chronic Kidney Disease in the FROM-J Study

    Okubo R.

    Journal of Renal Nutrition     2021年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Renal Nutrition  

    DOI: 10.1053/j.jrn.2020.12.008

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  10. Associations between peroxisome proliferator-activated receptor γ (PPAR-γ) polymorphisms and serum lipids: Two cross-sectional studies of community-dwelling adults.

    Matsunaga T, Naito M, Yin G, Hishida A, Okada R, Kawai S, Sasakabe T, Kadomatsu Y, Tsukamoto M, Kubo Y, Tamura T, Takeuchi K, Mori A, Hamajima N, Wakai K

    Gene   762 巻   頁: 145019   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Gene  

    DOI: 10.1016/j.gene.2020.145019

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  11. Association between alcohol intake pattern and metabolic syndrome components and simulated change by alcohol intake reduction: A cross-sectional study from the Japan Multi-Institutional Collaborative Cohort Study.

    Shimoshikiryo I, Ibusuki R, Shimatani K, Nishimoto D, Takezaki T, Nishida Y, Shimanoe C, Hishida A, Tamura T, Okada R, Kubo Y, Ozaki E, Matsui D, Suzuki S, Nakagawa-Senda H, Kuriki K, Kita Y, Takashima N, Arisawa K, Uemura H, Ikezaki H, Furusyo N, Oze I, Koyanagi YN, Mikami H, Nakamura Y, Naito M, Wakai K, J-MICC Study Group.

    Alcohol (Fayetteville, N.Y.)   89 巻   頁: 129 - 138   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Alcohol  

    DOI: 10.1016/j.alcohol.2020.09.002

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  12. Association between plasma levels of homocysteine, folate, and vitamin B<sub>12</sub>, and dietary folate intake and hypertension in a cross-sectional study.

    Tamura T, Kuriyama N, Koyama T, Ozaki E, Matsui D, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Hishida A, Sasakabe T, Kawai S, Naito M, Takashima N, Kadota A, Tanaka K, Hara M, Suzuki S, Nakagawa-Senda H, Takezaki T, Shimoshikiryo I, Ikezaki H, Murata M, Oze I, Ito H, Mikami H, Nakamura Y, Kuriki K, Arisawa K, Uemura H, Takeuchi K, Wakai K

    Scientific reports   10 巻 ( 1 ) 頁: 18499   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Scientific Reports  

    DOI: 10.1038/s41598-020-75267-3

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  13. A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population.

    Akashi A, Nakayama A, Kamatani Y, Higashino T, Shimizu S, Kawamura Y, Imoto M, Naito M, Hishida A, Kawaguchi M, Takao M, Matsuo M, Takada T, Ichida K, Ooyama H, Shinomiya N, Matsuo H

    Human cell   33 巻 ( 2 ) 頁: 303 - 307   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Human Cell  

    DOI: 10.1007/s13577-019-00318-5

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  14. Frequency of forest walking is not associated with prevalence of hypertension based on cross-sectional studies of a general Japanese population: a reconfirmation by the J-MICC Daiko Study.

    Morita E, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Sasakabe T, Kawai S, Hishida A, Naito M, Wakai K

    Nagoya journal of medical science   81 巻 ( 3 ) 頁: 489 - 500   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

    DOI: 10.18999/nagjms.81.3.489

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  15. Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study

    Iimuro Satoshi, Kaneko Tetsuji, Ohashi Yasuo, Watanabe Tsuyoshi, Nitta Kosaku, Akizawa Tadao, Matsuo Seiichi, Imai Enyu, Makino Hirofumi, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   23 巻 ( 7 ) 頁: 956 - 968   2019年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-019-01730-9

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  16. Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population.

    Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, Shimizu A, Wang C, Tanaka H, Watanabe M, Hosono A, Tamai Y, Yamada T, Yamaji T, Sawada N, Fukumoto K, Otsuka K, Tanno K, Tomita H, Kojima K, Nagasaki M, Hozawa A, Hishida A, Sasakabe T, Nishida Y, Hara M, Ito H, Oze I, Nakamura Y, Mikami H, Ibusuki R, Takezaki T, Koyama T, Kuriyama N, Endoh K, Kuriki K, Turin TC, Naoyuki T, Katsuura-Kamano S, Uemura H, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Sasaki M, Yamamoto M, Tsugane S, Wakai K, Suzuki S

    Sleep   42 巻 ( 6 )   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Sleep  

    DOI: 10.1093/sleep/zsz046

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  17. GENOME-WIDE META-ANALYSIS REVEALED MULTIPLE NOVEL LOCI ASSOCIATED WITH SERUM URIC ACIDLEVELS IN JAPANESE

    Matsuo Hirotaka, Nakatochi Masahiro, Kanai Masahiro, Nakayama Akiyoshi, Hishida Asahi, Kawamura Yusuke, Nakajima Mayuko, Kamatani Yoichiro, Shinomiya Nariyoshi, Yokota Mitsuhiro, Wakai Kenji, Okada Yukinori

    ANNALS OF THE RHEUMATIC DISEASES   78 巻   頁: 95 - 95   2019年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/annrheumdis-2019-eular.4039

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  18. Dysphagia after C2-7 in situ Posterior Fusion in a Patient with Diffuse Idiopathic Skeletal Hyperostosis: Case Report of a Rare Presentation

    Ito Kenyu, Kadono Izumi, Okada Takashi, Hishida Aika, Ando Kei, Kobayashi Kazuyoshi, Tsushima Mikito, Machino Masaaki, Ota Kyotaro, Morozumi Masayoshi, Tanaka Satoshi, Nishida Yoshihiro, Ishiguro Naoki, Imagama Shiro

    SPINE SURGERY AND RELATED RESEARCH   3 巻 ( 3 ) 頁: 270 - 273   2019年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Spine Surgery and Related Research  

    DOI: 10.22603/ssrr.2018-0083

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  19. Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population

    Fujii Ryosuke, Hishida Asahi, Wu Michael C., Kondo Takaaki, Hattori Yuta, Naito Mariko, Endoh Kaori, Nakatochi Masahiro, Hamajima Nobuyuki, Kubo Michiaki, Kuriki Kiyonori, Wakai Kenji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   80 巻 ( 1 ) 頁: 109 - 120   2018年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

    DOI: 10.18999/nagjms.80.1.109

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  20. Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study.

    Hishida A, Nakatochi M, Akiyama M, Kamatani Y, Nishiyama T, Ito H, Oze I, Nishida Y, Hara M, Takashima N, Turin TC, Watanabe M, Suzuki S, Ibusuki R, Shimoshikiryo I, Nakamura Y, Mikami H, Ikezaki H, Furusyo N, Kuriki K, Endoh K, Koyama T, Matsui D, Uemura H, Arisawa K, Sasakabe T, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Wakai K, Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.

    American journal of nephrology   47 巻 ( 5 ) 頁: 304 - 316   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Journal of Nephrology  

    DOI: 10.1159/000488946

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  21. Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change.

    Higashibata T, Wakai K, Naito M, Morita E, Hishida A, Hamajima N, Hara M, Suzuki S, Hosono S, Takashima N, Ohnaka K, Takada A, Mikami H, Watanabe Y, Uemura H, Kubo M, Tanaka H

    Gene   594 巻 ( 1 ) 頁: 16 - 22   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Gene  

    SIRT1 acts as a cellular sensor to detect energy availability and modulates fat and glucose metabolism. This study assessed the effects of self-reported calorie restriction (CR) and exercise on correlations between SIRT1 polymorphisms and body mass index (BMI) and long-term weight change. This cross-sectional study enrolled 4023 subjects aged 35-69years (1847 men and 2176 women) selected from participants in the Japan Multi-Institutional Collaborative Cohort Study. This study was based on a self-administered questionnaire. No significant correlations between SIRT1 polymorphisms and BMI or long-term weight change were found in either the CR or the active groups. In the no-CR group, women with the rs1467568 G allele had a higher BMI than women without (p=0.02). Moreover, women with the rs7895833 A or rs1467568 G allele gained more weight from the age of 20years than women without these alleles (p=0.03 for rs7895833 and p=0.003 for rs1467568). In addition, the odds ratios (95% confidence intervals) of these alleles for overweight (BMI &gt;27.5kg/m(2)) were significantly high in the no-CR women group (1.78 (1.06-2.99) for rs7895833 and 1.88 (1.13-3.15) for rs1467568) but not in the CR group. The results of this study suggest that CR might override the genetic contributions of the SIRT1 rs7895833 A and rs1467568 G alleles to BMI and long-term weight change.

    DOI: 10.1016/j.gene.2016.08.051

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  22. Metallothionein MT2A A-5G Polymorphism and the Risk for Chronic Kidney Disease and Diabetes

    Hattori Yuta, Naito Mariko, Satoh Masahiko, Nakatochi Masahiro, Naito Hisao, Kato Masashi, Takagi Sahoko, Matsunaga Takashi, Seiki Toshio, Sasakabe Tae, Suma Shino, Kawai Sayo, Okada Rieko, Hishida Asahi, Hamajima Nobuyuki, Wakai Kenji

    TOXICOLOGICAL SCIENCES   154 巻 ( 2 ) 頁: 198 - 199   2016年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/toxsci/kfw204

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  23. Variant of the clock circadian regulator (CLOCK) gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population

    Uemura Hirokazu, Katsuura-Kamano Sakurako, Yamaguchi Miwa, Arisawa Kokichi, Hamajima Nobuyuki, Hishida Asahi, Kawai Sayo, Oze Isao, Shinchi Koichi, Takashima Naoyuki, Suzuki Sadao, Nakahata Noriko, Mikami Haruo, Ohnaka Keizo, Kuriyama Nagato, Kubo Michiaki, Tanaka Hideo

    JOURNAL OF DIABETES   8 巻 ( 5 ) 頁: 667 - 676   2016年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Circadian rhythm disruption is recognized as the cause of various health disorders. This study evaluated associations between single nucleotide polymorphisms in the core circadian gene, CLOCK, and prevalent type 2 diabetes in the Japanese population. We analyzed cross-sectional data from 2,485 subjects (1,243 men and 1,242 women; age, 35-69 years) who were enrolled in the baseline surveys of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Associations between 3 CLOCK gene polymorphisms (rs1801260, rs3736544, and rs4864548) and prevalent obesity (BMI ?25 kg/m(2) ), overweight (BMI ?23 kg/m(2) ), and diabetes were evaluated by logistic regression analyses; haplotype analysis and stratified analyses for prevalent diabetes were also conducted. Compared to those who were homozygous for the respective major alleles, subjects with the rs1801260 minor allele C showed a significantly higher odds ratio (95% CI) of 1.5 (1.1-2.1) for prevalent diabetes, after adjustment for potential confounding factors, including BMI. When stratified by overweight, the associations between rs1801260 and prevalent diabetes were marked and significant in non-overweight subjects but were not significant in overweight subjects. The TGA (rs1801260 - rs3736544 - rs4864548) haplotype was associated with lower prevalence of diabetes, and the CGG haplotype was associated with higher prevalence of diabetes. CLOCK gene variants and related haplotypes are associated with prevalent type 2 diabetes in the Japanese population in whom obesity is less common, and the association between a CLOCK gene variants at rs1801260 and prevalent diabetes is enhanced in normal-build subjects.

    DOI: 10.1111/1753-0407.12344

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  24. SERUM URIC ACID IS ASSOCIATED WITH WITHIN-VISIT BLOOD PRESSURE VARIABILITY AMONG WOMEN; THE RESULTS OF A FIVE YEAR SURVEY FROM THE J-MICC DAIKO STUDY

    Okada Rieko, Naito Mariko, Morita Emi, Takagi Sahoko, Matsunaga Takashi, Seiki Toshio, Sasakabe Tae, Hattori Yuta, Kawai Sayo, Hishida Asahi, Hamajima Nobuyuki, Wakai Kenji

    JOURNAL OF HYPERTENSION   34 巻   頁: E260 - E260   2016年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  25. Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies.

    Hattori Y, Naito M, Satoh M, Nakatochi M, Naito H, Kato M, Takagi S, Matsunaga T, Seiki T, Sasakabe T, Suma S, Kawai S, Okada R, Hishida A, Hamajima N, Wakai K

    Toxicological sciences : an official journal of the Society of Toxicology   152 巻 ( 1 ) 頁: 181 - 93   2016年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Toxicological Sciences  

    DOI: 10.1093/toxsci/kfw080

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  26. Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study.

    Yamaguchi M, Uemura H, Arisawa K, Katsuura-Kamano S, Hamajima N, Hishida A, Suma S, Oze I, Nakamura K, Takashima N, Suzuki S, Ibusuki R, Mikami H, Ohnaka K, Kuriyama N, Kubo M, Tanaka H, Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group.

    Diabetes research and clinical practice   110 巻 ( 3 ) 頁: 301 - 8   2015年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Diabetes Research and Clinical Practice  

    Brain-muscle-Arnt-like protein-1 (BMAL1) and BMAL2 genes are essential components of the circadian clock, and are considered to be involved in glucose homeostasis. We examined whether single nucleotide polymorphisms (SNPs) of BMAL1 and BMAL2 were associated with the prevalence of type 2 diabetes (T2DM) in the general Japanese population. We studied 2467 subjects (1232 men and 1235 women, 35-69 years old), including 105 men and 57 women with T2DM, from the participants of the Japan Multi-institutional Collaborative Cohort Study. The association between SNPs in the BMAL1 (rs11022775 and rs2290035) and BMAL2 (rs7958822) genes and T2DM were analyzed by multiple logistic regression after adjustment for potential confounders. Analysis was also performed after stratification by body mass index (?25kg/m(2) and &lt;25kg/m(2)) to investigate an interaction between genotypes and obesity. The A/G and A/A genotypes of BMAL2 rs7958822 showed significantly higher adjusted odds ratios (OR) for T2DM than the G/G genotype among obese men (OR=2.2, 95% confidence intervals [CI] 1.1, 4.6, P for interaction=0.0495) and obese women (OR=2.7, 95% CI 1.1, 6.7, P for interaction=0.199). There were no significant associations between BMAL1 rs11022775 or rs2290035 genotypes and T2DM. To the best of our knowledge, this is the first study to show the significant association between BMAL2 rs7958822 genotype and T2DM among obese subjects.

    DOI: 10.1016/j.diabres.2015.10.009

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  27. ATP-binding cassette transporter A1 (ABCA1) R219K (G1051A, rs2230806) polymorphism and serum high-density lipoprotein cholesterol levels in a large Japanese population: cross-sectional data from the Daiko Study

    Mokuno Junichiro, Hishida Asahi, Morita Emi, Sasakabe Tae, Hattori Yuta, Suma Shino, Okada Rieko, Kawai Sayo, Naito Mariko, Wakai Kenji

    ENDOCRINE JOURNAL   62 巻 ( 6 ) 頁: 543 - 549   2015年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  28. Hyperbaric area index calculated from ABPM elucidates the condition of CKD patients: the CKD-JAC study

    Iimuro Satoshi, Imai Enyu, Watanabe Tsuyoshi, Nitta Kosaku, Akizawa Tadao, Matsuo Seiichi, Makino Hirofumi, Ohashi Yasuo, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   19 巻 ( 1 ) 頁: 114 - 124   2015年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-014-0965-2

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  29. ATP-binding cassette transporter A1 (ABCA1) R219K (G1051A, rs2230806) polymorphism and serum high-density lipoprotein cholesterol levels in a large Japanese population: cross-sectional data from the Daiko Study.

    Mokuno J, Hishida A, Morita E, Sasakabe T, Hattori Y, Suma S, Okada R, Kawai S, Naito M, Wakai K

    Endocrine journal   62 巻 ( 6 ) 頁: 543 - 9   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endocrine Journal  

    DOI: 10.1507/endocrj.EJ14-0577

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  30. Significant Associations of Abdominal Obesity with LYPLAL1 Polymorphism (rs4846567) among a General Japanese Population: A Cross-Sectional Study.

    Tamura T., Morita E., Kawai S., Sasakabe T., Fukuda N., Sugimoto Y., Suma S., Mokuno J., Nakagawa H., Hishida A., Okada R., Naito M., Hamajima N., Wakai K.

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY   44 巻   頁: 243 - 244   2015年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  31. Validation of the General Oral Health Assessment (GOHAI) Index into Japanese adults

    Naito Mariko, Suzukamo Yoshimi, Suma Shino, Kawai Sayo, Okada Rieko, Hishida Asahi, Morita Emi, Hamajima Nobuyuki, Wakai Kenji

    QUALITY OF LIFE RESEARCH   23 巻   頁: 173 - 173   2014年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  32. Taming the chronic kidney disease epidemic: a global view of surveillance efforts

    Radhakrishnan Jai, Remuzzi Giuseppe, Saran Rajiv, Williams Desmond E., Rios-Burrows Nilka, Powe Neil, Bruck Katharina, Wanner Christoph, Stel Vianda S., Venuthurupalli Sree K., Hoy Wendy E., Healy Helen G., Salisbury Anne, Fassett Robert G., O'Donoghue Donal, Roderick Paul, Matsuo Seiichi, Hishida Akira, Imai Enyu, Iimuro Satoshi, Consortium European C. K. D. Burden, Grp C. K. D. Q. L. D.

    KIDNEY INTERNATIONAL   86 巻 ( 2 ) 頁: 246 - 250   2014年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Kidney International  

    Chronic kidney disease is now recognized to be a worldwide problem associated with significant morbidity and mortality and there is a steep increase in the number of patients reaching end-stage renal disease. In many parts of the world, the disease affects younger people without diabetes or hypertension. The costs to family and society can be enormous. Early recognition of CKD may help prevent disease progression and the subsequent decline in health and longevity. Surveillance programs for early CKD detection are beginning to be implemented in a few countries. In this article, we will focus on the challenges and successes of these programs with the hope that their eventual and widespread use will reduce the complications, deaths, disabilities, and economic burdens associated with CKD worldwide. © 2014 International Society of Nephrology.

    DOI: 10.1038/ki.2014.190

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  33. GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: data from the J-MICC Study.

    Hishida A, Takashima N, Turin TC, Kawai S, Wakai K, Hamajima N, Hosono S, Nishida Y, Suzuki S, Nakahata N, Mikami H, Ohnaka K, Matsui D, Katsuura-Kamano S, Kubo M, Tanaka H, Kita Y

    Journal of nephrology   27 巻 ( 2 ) 頁: 143 - 9   2014年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Nephrology  

    Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of glucokinase and glucokinase regulatory protein (GCKR) polymorphisms with the risk of CKD in Japan, we examined this association among Japanese individuals using cross-sectional data. The subjects for this analysis were 3,314 consecutively selected participants from the Japan Multi-Institutional Collaborative Cohort Study. Age- and sex- adjusted odds ratios (aORs) of CKD stages 3-5 were calculated for each genotype by logistic regression and the effects of genotype on estimated glomerular filtration rate were evaluated by linear regression. Gene-environment interaction was also investigated based on questionnaire information. When subjects with GCKR rs780094 G/A and G/G, or GCKR rs1260326 T/C and C/C were combined together and compared with the references (GCKR rs780094 A/A or GCKR rs1260326 T/T), the aORs were 0.84 (0.69-1.02) or 0.81 (0.67-0.99) (p = 0.075 or 0.037), respectively. A significant OR for interaction between GCKR rs1260326 T/T and current smoking (OR = 1.79, p = 0.041) was also observed. The present study suggests a possible association of the T/T genotype of GCKR rs1260326 polymorphism with elevated risk of CKD and its interaction with current smoking, which may support the possibility of performing risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.

    DOI: 10.1007/s40620-013-0025-0

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  34. Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility.

    Nakayama A, Matsuo H, Shimizu T, Ogata H, Takada Y, Nakashima H, Nakamura T, Shimizu S, Chiba T, Sakiyama M, Ushiyama C, Takada T, Inoue K, Kawai S, Hishida A, Wakai K, Hamajima N, Ichida K, Sakurai Y, Kato Y, Shimizu T, Shinomiya N

    Human cell   26 巻 ( 4 ) 頁: 133 - 6   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s13577-013-0073-8

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  35. A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility

    Nakayama A.

    Human Cell   26 巻 ( 4 ) 頁: 133 - 136   2013年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Human Cell  

    DOI: 10.1007/s13577-013-0073-8

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  36. A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility

    Nakayama Akiyoshi, Matsuo Hirotaka, Shimizu Takuya, Ogata Hiraku, Takada Yuzo, Nakashima Hiroshi, Nakamura Takahiro, Shimizu Seiko, Chiba Toshinori, Sakiyama Masayuki, Ushiyama Chisaki, Takada Tappei, Inoue Katsuhisa, Kawai Sayo, Hishida Asahi, Wakai Kenji, Hamajima Nobuyuki, Ichida Kimiyoshi, Sakurai Yutaka, Kato Yukio, Shimizu Toru, Shinomiya Nariyoshi

    HUMAN CELL   26 巻 ( 4 ) 頁: 133 - 136   2013年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s13577-013-0073-8

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  37. Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease (Retracted article. See vol. 21, pg. 1146, 2017)

    Nitta Kosaku, Iimuro Satoshi, Imai Enyu, Matsuo Seiichi, Makino Hirofumi, Akizawa Tadao, Watanabe Tsuyoshi, Ohashi Yasuo, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   17 巻 ( 5 ) 頁: 730 - 742   2013年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-012-0758-4

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  38. A NEW INDICATOR CALCULATED FROM ABPM ELUCIDATES THE RELATION BETWEEN ANTIHYPERTENSIVE PRESCRIBING AND BLOOD PRESSURE LOAD; FROM THE CKD-JAC STUDY

    Iimuro Satoshi, Imai Enyu, Matsuo Seiichi, Watanabe Tsuyoshi, Nitta Kosaku, Akizawa Tadao, Makino Hirofumi, Ohashi Yasuo, Hishida Akira

    NEPHROLOGY DIALYSIS TRANSPLANTATION   28 巻   頁: 330 - 330   2013年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  39. Clinical Correlates of Ambulatory BP Monitoring among Patients with CKD

    Iimuro Satoshi, Imai Enyu, Watanabe Tsuyoshi, Nitta Kosaku, Akizawa Tadao, Matsuo Seiichi, Makino Hirofumi, Ohashi Yasuo, Hishida Akira

    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   8 巻 ( 5 ) 頁: 721 - 730   2013年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Journal of the American Society of Nephrology  

    DOI: 10.2215/CJN.06470612

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  40. Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese - The J-MICC Study

    Hishida A., Wakai K., Okada R., Morita E., Hamajima N., Hosono S., Higaki Y., Turin T.C., Suzuki S., Motahareh K., Mikami H., Tashiro N., Watanabe I., Katsuura S., Kubo M., Tanaka H., Naito M.

    Endocrine Journal   60 巻 ( 2 ) 頁: 237 - 243   2013年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endocrine Journal  

    We examined the association of the RETN (resistin) -420 C>G polymorphism (rs1862513) with risk of diabetes mellitus (DM), considering lifestyle factors, in Japanese. Subjects were participants of J-MICC Study, where 2,651 participants aged 35-69 years provided their blood for genotyping and lifestyle data after informed consent. Odds ratio (OR) of DM for RETN-420 G/G genotype was estimated using unconditional logistic regression model. Statistically significant interaction on risk of DM was observed between RETN-420 G/G genotype and BMI<25 (OR for interaction = 0.12; P = 0.046), and when subjects with RETN-420 C/C+C/G and BMI ≥ 25 (n = 69 for DM and 544 for non-DM) were defined as the reference, the adjusted ORs for subjects with RETN-420 G/G genotype and BMI>25 (n = 10 for DM and 111 for non- DM), RETN-420 C/C+C/G and BMI<25 (n = 81 for DM and 1,605 for non-DM), and RETN-420 G/G and BMI < 25 (n = 1 for DM and 230 for non-DM) were demonstrated to be 0.72 (95% confidence interval: 0.36-1.46), 0.40 (0.28-0.56) and 0.03 (0.005-0.25), respectively. The present study revealed the significant interaction of RETN-420 G/G genotype with lower BMI on the decreased risk of DM, but the direction was opposite to the reported ones in Japanese. We should be careful in interpretation of the present study results because of the limited sample sizes. Further investigation of this association as well as of the actual biological roles of RETN in the genesis of human metabolic disorders including DM will be required. ©The Japan Endocrine Society.

    DOI: 10.1507/endocrj.EJ12-0307

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  41. Significant interaction between RETN-420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese - the J-MICC Study

    Hishida Asahi, Wakai Kenji, Okada Rieko, Morita Emi, Hamajima Nobuyuki, Hosono Satoyo, Higaki Yasuki, Turin Tanvir Chowdhury, Suzuki Sadao, Motahareh Kheradmand, Mikami Haruo, Tashiro Naotaka, Watanabe Isao, Katsuura Sakurako, Kubo Michiaki, Tanaka Hideo, Naito Mariko

    ENDOCRINE JOURNAL   60 巻 ( 2 ) 頁: 237 - 243   2013年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  42. Association of obesity and diabetes with serum prostate-specific antigen levels in Japanese males

    Naito M.

    Nagoya Journal of Medical Science   74 巻 ( 3-4 ) 頁: 285 - 292   2012年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

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  43. Prevalence of helicobacter pylori infection measured with urinary antibody in an urban area of japan, 2008-2010

    Tamura T.

    Nagoya Journal of Medical Science   74 巻 ( 1-2 ) 頁: 63 - 70   2012年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

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  44. Association of obesity and diabetes with serum prostate-specific antigen levels in Japanese males.

    Naito M, Asai Y, Mori A, Fukada Y, Kuwabara M, Katase S, Hishida A, Morita E, Kawai S, Okada R, Nishio K, Tamakoshi A, Wakai K, Hamajima N

    Nagoya journal of medical science   74 巻 ( 3-4 ) 頁: 285 - 92   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  45. ASSOCIATION OF OBESITY AND DIABETES WITH SERUM PROSTATE-SPECIFIC ANTIGEN LEVELS IN JAPANESE MALES

    Naito Mariko, Asai Yatami, Mori Atsuyoshi, Fukada Yuko, Kuwabara Mayumi, Katase Shiro, Hishida Asahi, Morita Emi, Kawai Sayo, Okada Rieko, Nishio Kazuko, Tamakoshi Akiko, Wakai Kenji, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   74 巻 ( 3-4 ) 頁: 285 - 292   2012年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  46. Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study

    Hishida Asahi, Morita Emi, Naito Mariko, Okada Rieko, Wakai Kenji, Matsuo Keitaro, Nakamura Kazuyo, Takashima Naoyuki, Suzuki Sadao, Takezaki Toshiro, Mikami Haruo, Ohnaka Keizo, Watanabe Yoshiyuki, Uemura Hirokazu, Kubo Michiaki, Tanaka Hideo, Hamajima Nobuyuki

    ENDOCRINE JOURNAL   59 巻 ( 7 ) 頁: 589 - 599   2012年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  47. STUDY PROFILE ON BASELINE SURVEY OF DAIKO STUDY IN THE JAPAN MULTI-INSTITUTIONAL COLLABORATIVE COHORT STUDY (J-MICC STUDY)

    Morita Emi, Hamajima Nobuyuki, Hishida Asahi, Aoyama Kyoko, Okada Rieko, Kawai Sayo, Tomita Koutaro, Kuriki Sayaka, Tamura Takashi, Naito Mariko, Kondo Takaaki, Ueyama Jun, Kimata Akiko, Yamamoto Kanami, Hori Yoko, Hoshino Junko, Hamamoto Ritsuko, Tsukamoto Sanae, Onishi Joji, Hagikura Shoichi, Naito Hisao, Hibi Satoshi, Ito Yoshinori, Wakai Kenji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   73 巻 ( 3-4 ) 頁: 187 - 195   2011年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  48. Study profile on baseline survey of Daiko Study in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study).

    Morita E., Hamajima N., Hishida A., Aoyama K., Okada R., Kawai S., Tomita K., Kuriki S., Tamura T., Naito M., Kondo T., Ueyama J., Kimata A., Yamamoto K., Hori Y., Hoshinos J., Hamamotos R., Tsukamoto S., Onishi J., Hagikura S., Naito H., Hibi S., Ito Y., Wakai K.

    Nagoya journal of medical science   73 巻 ( 3-4 ) 頁: 187 - 195   2011年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya journal of medical science  

    The Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) is a long-term cohort study to investigate the interactions among genotypes, lifestyles, and lifestyle-related diseases, especially cancer. This article reports the outline of the baseline survey of the Daiko Study, one site of the J-MICC Study. That survey was conducted between June 9, 2008 and May 31, 2010 at the Daiko Medical Center of Nagoya University in Nagoya, Japan. Subjects were registered residents of Nagoya City aged 35 to 69 years who had not participated in other J-MICC sites. Recruitment was mainly announced through leaflets distributed in mailboxes citywide, personal communications, and regional information, such as posters in public or commercial facilities. Participants provided blood plasma, serum, buffy coat, urine, and data on health check-ups. They also completed a self-reported questionnaire on lifestyle, disease history, family history, and for women, reproductive history. As of the end of September 2010, 4 out of 5172 registered participants had withdrawn from the study, leaving data from 5168 participants (1467 males and 3701 females) available for analysis. Mean age +/- standard deviation (SD) was 52.5 +/- 10.3 years. Current smokers accounted for 24.1% (n=354) of males and 6.9% (n=256) of females. Current drinkers included 74.9% (n=1099) of males and 45.9% (n=1699) of females. Lifestyle data and specimens were successfully collected to examine any associations among disease biomarkers, lifestyles, and genotypes.

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  49. Management of anemia in chronic kidney disease patients: baseline findings from Chronic Kidney Disease Japan Cohort Study

    Akizawa Tadao, Makino Hirofumi, Matsuo Seiichi, Watanabe Tsuyoshi, Imai Enyu, Nitta Kosaku, Ohashi Yasuo, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   15 巻 ( 2 ) 頁: 248 - 257   2011年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-010-0396-7

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  50. ASSOCIATION OF UGT1A1 GLY71ARG WITH URINE UROBILINOGEN

    Kataoka Ryuji, Kimata Akiko, Yamamoto Kanami, Hirosawa Naoko, Ueyama Jun, Kondo Takaaki, Okada Rieko, Kawai Sayo, Hishida Asahi, Naito Mariko, Morita Emi, Wakai Kenji, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   73 巻 ( 1-2 ) 頁: 33 - 40   2011年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  51. Association of UGT1A1 Gly71Arg with urine urobilinogen.

    Kataoka R.

    Nagoya journal of medical science   73 巻 ( 1-2 ) 頁: 33 - 40   2011年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya journal of medical science  

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  52. Chronic Kidney Disease Japan Cohort study: baseline characteristics and factors associated with causative diseases and renal function

    Imai Enyu, Matsuo Seiichi, Makino Hirofumi, Watanabe Tsuyoshi, Akizawa Tadao, Nitta Kosaku, Iimuro Satoshi, Ohashi Yasuo, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   14 巻 ( 6 ) 頁: 558 - 570   2010年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-010-0328-6

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  53. Erratum: Chronic Kidney Disease Japan Cohort study: Baseline characteristics and factors associated with causative diseases and renal function (Clin Exp Nephrol DOI: 10.1007/s10157-010-0328-6)

    Imai E.

    Clinical and Experimental Nephrology   14 巻 ( 6 ) 頁: 571 - 572   2010年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-010-0352-6

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  54. Smoking Behavior and Risk of Helicobacter Pylori Infection, Gastric Atrophy and Gastric Cancer in Japanese

    Hishida Asahi, Matsuo Keitaro, Goto Yasuyuki, Naito Mariko, Wakai Kenji, Tajima Kazuo, Hamajima Nobuyuki

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   11 巻 ( 2 ) 頁: 313 - 317   2010年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  55. A large-scale survey of health check-up visitors in the West-Central area of Shizuoka Prefecture regarding the frequency of walking in forested areas

    Morita E.

    Nihon Ringakkai Shi/Journal of the Japanese Forestry Society   92 巻 ( 2 ) 頁: 110 - 114   2010年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nihon Ringakkai Shi/Journal of the Japanese Forestry Society  

    DOI: 10.4005/jjfs.92.110

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  56. Smoking Behavior and Risk of Helicobacter Pylori Infection, Gastric Atrophy and Gastric Cancer in Japanese

    Hishida Asahi, Matsuo Keitaro, Goto Yasuyuki, Naito Mariko, Wakai Kenji, Tajima Kazuo, Hamajima Nobuyuki

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   11 巻 ( 3 ) 頁: 669 - 673   2010年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  57. Smoking behavior and risk of Helicobacter pylori infection, gastric atrophy and gastric cancer in Japanese

    Hishida A., Matsuo K., Goto Y., Naito M., Wakai K., Tajima K., Hamajima N.

    Asian Pacific Journal of Cancer Prevention   11 巻 ( 2 ) 頁: 313 - 317   2010年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Asian Pacific Journal of Cancer Prevention  

    Although many studies have shown that smoking is an established risk factor for gastric cancer, relatively few studies have investigated on which step smoking has effects in Helicobacter pylori (H. pylori) related gastric carcinogenesis. In this study we investigated the association of smoking with risk of three steps leading to gastric cancer: H. pylori infection, gastric atrophy, and gastric cancer. Among the participants who visited Aichi Cancer Center Hospital from year 2001 to 2005, 583 cases diagnosed as gastric cancer and age-and sex-frequency-matched 1,742 cancer free controls were sampled, from whom those without serum samples or without information about smoking habit were excluded, leaving 576 cases and 1,599 controls eligible for the analyses. Anti-H. pylori IgG antibody and serum pepsinogens (PG) were measured to detect H. pylori infection and gastric atrophy. Smoking status was asked by a self-administered questionnaire. The odds ratio (OR) of H. pylori infection, as well as the OR of gastric atrophy among the H. pylori seropositive controls was not significant for smokers. The age- and sex-adjusted OR of gastric cancer was significantly elevated relative to the subjects with gastric atrophy: OR=1.62 (95% confidence interval (CI), 1.19-2.22; P=0.002) for ever smokers and 2.52 (1.75-3.64; P<0.001) for current smokers, relative to never smokers. This study revealed that smoking behavior contributed to the increased risk of gastric carcinogenesis from gastric atrophy, but had little influence on H. pylori infection or gastric atrophy development.

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  58. Smoking behavior and risk of Helicobacter Pylori infection, gastric atrophy and gastric cancer in Japanese

    Hishida A., Matsuo K., Goto Y., Naito M., Wakai K., Tajima K., Hamajima N.

    Asian Pacific Journal of Cancer Prevention   11 巻 ( 3 ) 頁: 669 - 673   2010年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Asian Pacific Journal of Cancer Prevention  

    Although many studies have shown that smoking is an established risk factor for gastric cancer, relatively few studies have investigated on which step smoking has effects in Helicobacter pylori (H. pylori) related gastric carcinogenesis. In this study we investigated the association of smoking with risk of three steps leading to gastric cancer: H. pylori infection, gastric atrophy, and gastric cancer. Among the participants who visited Aichi Cancer Center Hospital from year 2001 to 2005, 583 cases diagnosed as gastric cancer and age-and sex-frequency-matched 1,742 cancer free controls were sampled, from whom those without serum samples or without information about smoking habit were excluded, leaving 576 cases and 1,599 controls eligible for the analyses. Anti- H. pylori IgG antibody and serum pepsinogens (PG) were measured to detect H. pylori infection and gastric atrophy. Smoking status was asked by a self-administered questionnaire. The odds ratio (OR) of H. pylori infection, as well as the OR of gastric atrophy among the H. pylori seropositive controls was not significant for smokers. The age- and sex-adjusted OR of gastric cancer was significantly elevated relative to the subjects with gastric atrophy: OR=1.62 (95% confidence interval (CI), 1.19-2.22; P=0.002) for ever smokers and 2.52 (1.75-3.64; P<0.001) for current smokers, relative to never smokers. This study revealed that smoking behavior contributed to the increased risk of gastric carcinogenesis from gastric atrophy, and had little influence on H. pylori infection or gastric atrophy development.

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  59. Smoking behavior and risk of Helicobacter pylori infection, gastric atrophy and gastric cancer in Japanese.

    Hishida A, Matsuo K, Goto Y, Naito M, Wakai K, Tajima K, Hamajima N

    Asian Pacific journal of cancer prevention : APJCP   11 巻 ( 3 ) 頁: 669 - 73   2010年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PubMed

  60. Erratum to: Prevalence of chronic kidney disease in the Japanese general population (Clinical and Experimental Nephrology DOI: 10.1007/s10157-009-0199-x)

    Imai E.

    Clinical and Experimental Nephrology   13 巻 ( 6 ) 頁: 631 - 632   2009年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-009-0238-7

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  61. Prevalence of chronic kidney disease in the Japanese general population

    Imai Enyu, Horio Masaru, Watanabe Tsuyoshi, Iseki Kunitoshi, Yamagata Kunihiro, Hara Shigeko, Ura Nobuyuki, Kiyohara Yutaka, Moriyama Toshiki, Ando Yasuhiro, Fujimoto Shoichi, Konta Tsuneo, Yokoyama Hitoshi, Makino Hirofumi, Hishida Akira, Matsuo Seiichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   13 巻 ( 6 ) 頁: 621 - 630   2009年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-009-0199-x

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  62. BASELINE DATA OF SHIZUOKA AREA IN THE JAPAN MULTI-INSTITUTIONAL COLLABORATIVE COHORT STUDY (J-MICC STUDY)

    Asai Yatami, Naito Mariko, Suzuki Masumi, Tomoda Akiko, Kuwabara Mayumi, Fukada Yuko, Okamoto Ayumi, Oishi Sachie, Ikeda Kanako, Nakamura Tsukino, Misu Yasuko, Katase Shiroh, Tokumasu Satoshi, Nishio Kazuko, Ishida Yoshiko, Hishida Asahi, Morita Emi, Kawai Sayo, Okada Rieko, Wakai Kenji, Tamakoshi Akiko, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   71 巻 ( 3-4 ) 頁: 137 - 144   2009年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  63. Report of the Asian Forum of Chronic Kidney Disease Initiative (AFCKDI) 2007. "Current status and perspective of CKD in Asia": diversity and specificity among Asian countries

    Tsukamoto Yusuke, Wang HaiYan, Becker Gavin, Chen Hung-Chun, Han Dae-Suk, Harris David, Imai Enyu, Jha Vivekanand, Li Philip K. T., Lee Evan J. C., Matsuo Seiichi, Tomino Yasuhiko, Tungsanga Kriang, Yamagata Kunihiro, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   13 巻 ( 3 ) 頁: 249 - 256   2009年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    The Japanese Society of Nephrology (JSN) sponsored the Asian Forum of CKD Initiative (AFCKDI) 2007 with the support of the International Society of Nephrology-Commission for Global Advancement in Nephrology (ISN-COMGAN), Asian Pacific Society of Nephrology (APSN), the Kidney Disease: Improving Global Outcome (KDIGO) and other national societies of nephrology in the Asian Pacific region on 27-28 May 2007 in Hamamatsu City, Japan. An international organising committee was established by leading experts of the CKD initiative. The main objective of this forum was to clarify the current status and perspectives of CKD and to promote coordination, collaboration and integration of initiatives in the Asian Pacific region. The forum received 56 papers from 16 countries; it began with the symposium "A Challenge to CKD in the world" and was followed by the ISN-COMGAN affiliated workshop "Current status and perspective of CKD in Asia". The second day was dedicated to discussion on the evaluation, surveillance and intervention in CKD in this area. At the end of the forum, we decided on the future plan as follows: (1) The AFCKDI will provide opportunities annually or biannually for every person who promotes CKD initiatives in the Asian Pacific region to join together and build consensus for action; (2) the second forum will be held in Kuala Lumpur on 4 May 2008 at the time of the 11th Asian Pacific Congress of Nephrology (APCN). Zaki Morad, President of the 11th APCN, will host the second forum; (3) the International Organising Committee (IOC) of the 1st AFCKDI will continue its function by adding other experts, including the organisers of the APCN; (4) the AFCKDI is not an organisation by itself, nor does it belong to any society, but is organised by each host national society of nephrology. The IOC will assist the domestic committee for the success of the forum and will assure the continuation of the mission; (5) in order to organise the forum and promote CKD initiatives in the Asia Pacific region, the AFCKDI will look for support by both national and international societies. The AFCKDI will keep an intimate and mutual relation with the ISN, APSN and KDIGO. © 2009 Japanese Society of Nephrology.

    DOI: 10.1007/s10157-009-0156-8

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  64. Revised Equations for Estimated GFR From Serum Creatinine in Japan

    Matsuo Seiichi, Imai Enyu, Horio Masaru, Yasuda Yoshinari, Tomita Kimio, Nitta Kosaku, Yamagata Kunihiro, Tomino Yasuhiko, Yokoyama Hitoshi, Hishida Akira

    AMERICAN JOURNAL OF KIDNEY DISEASES   53 巻 ( 6 ) 頁: 982 - 992   2009年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Journal of Kidney Diseases  

    Background: Estimation of glomerular filtration rate (GFR) is limited by differences in creatinine generation among ethnicities. Our previously reported GFR-estimating equations for Japanese had limitations because all participants had a GFR less than 90 mL/min/1.73 m2 and serum creatinine was assayed in different laboratories. Study Design: Diagnostic test study using a prospective cross-sectional design. New equations were developed in 413 participants and validated in 350 participants. All samples were assayed in a central laboratory. Setting & Participants: Hospitalized Japanese patients in 80 medical centers. Patients had not participated in the previous study. Reference Test: Measured GFR (mGFR) computed from inulin clearance. Index Test: Estimated GFR (eGFR) by using the modified isotope dilution mass spectrometry (IDMS)-traceable 4-variable Modification of Diet in Renal Disease (MDRD) Study equation using the previous Japanese Society of Nephrology Chronic Kidney Disease Initiative (JSN-CKDI) coefficient of 0.741 (equation 1), the previous JSN-CKDI equation (equation 2), and new equations derived in the development data set: modified MDRD Study using a new Japanese coefficient (equation 3), and a 3-variable Japanese equation (equation 4). Measurements: Performance of equations was assessed by means of bias (eGFR-mGFR), accuracy (percentage of estimates within 15% or 30% of mGFR), root mean squared error, and correlation coefficient. Results: In the development data set, the new Japanese coefficient was 0.808 (95% confidence interval, 0.728 to 0.829) for the IDMS-MDRD Study equation (equation 3), and the 3-variable Japanese equation (equation 4) was eGFR (mL/min/1.73 m2) = 194 × Serum creatinine-1.094 × Age-0.287 × 0.739 (if female). In the validation data set, bias was -1.3 ± 19.4 versus -5.9 ± 19.0 mL/min/1.73 m2 (P = 0.002), and accuracy within 30% of mGFR was 73% versus 72% (P = 0.6) for equation 3 versus equation 1 and-2.1±19.0 versus-7.9±18.7 mL/min/1.73m2 (P<0.001) and 75% versus 73% (P= 0.06) for equation 4 versus equation 2 (P = 0.06), respectively. Limitation: Most study participants had chronic kidney disease, and some may have had changing GFRs. Conclusion: The new Japanese coefficient for the modified IDMS-MDRD Study equation and the new Japanese equation are more accurate for the Japanese population than the previously reported equations. Am J Kidney Dis 53:982-992.

    DOI: 10.1053/j.ajkd.2008.12.034

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  65. Applicability of allele/genotype frequency from documented controls for case-control studies on genotypes among Japanese: MTHFR C677T as an example.

    Iida K, Tomita K, Okada R, Kawai S, Morita E, Hishida A, Naito M, Wakai K, Hamajima N

    Asian Pacific journal of cancer prevention : APJCP   10 巻 ( 2 ) 頁: 231 - 6   2009年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

    PubMed

  66. Applicability of allele/genotype frequency from documented controls for case-control studies on genotypes among Japanese: MTHFR C677T as an example

    Iida K.

    Asian Pacific Journal of Cancer Prevention   10 巻 ( 2 ) 頁: 231 - 236   2009年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Asian Pacific Journal of Cancer Prevention  

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  67. Applicability of Allele/genotype Frequency from Documented Controls for Case-Control Studies on Genotypes among Japanese: MTHFR C677T as an Example

    Iida Kenta, Tomita Koutaro, Okada Rieko, Kawai Sayo, Morita Emi, Hishida Asahi, Naito Mariko, Wakai Kenji, Hamajima Nobuyuki

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   10 巻 ( 2 ) 頁: 231 - 236   2009年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  68. Controls for monitoring the deterioration of stored blood samples in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study).

    Naito M.

    Nagoya journal of medical science   70 巻 ( 3-4 ) 頁: 107 - 115   2008年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya journal of medical science  

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  69. Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products

    Makino T.

    Journal of Natural Medicines   62 巻 ( 3 ) 頁: 294 - 299   2008年7月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Natural Medicines  

    DOI: 10.1007/s11418-008-0230-7

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  70. Chronic Kidney Disease Japan Cohort (CKD-JAC) study: Design and methods

    Imai Enyu, Matsuo Seiichi, Makino Hirofumi, Watanabe Tsuyoshi, Akizawa Tadao, Nitta Kosaku, Iimuro Satoshi, Ohashi Yasuo, Hishida Akira

    HYPERTENSION RESEARCH   31 巻 ( 6 ) 頁: 1101 - 1107   2008年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  71. Chronic kidney disease Japan cohort (CKD-JAC) Study: Design and methods

    Imai E.

    Hypertension Research   31 巻 ( 6 ) 頁: 1101 - 1107   2008年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Hypertension Research  

    DOI: 10.1291/hypres.31.1101

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  72. Slower decline of glomerular filtration rate in the Japanese general population: A longitudinal 10-year follow-up study

    Imai Enyu, Horio Masaru, Yamagata Kunihiro, Iseki Kunitoshi, Hara Shigeko, Ura Nobuyuki, Kiyohara Yutaka, Makino Hirofumi, Hishida Akira, Matsuo Seiichi

    HYPERTENSION RESEARCH   31 巻 ( 3 ) 頁: 433 - 441   2008年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  73. Slower decline of glomerular filtration rate in the Japanese general population: A longitudinal 10-year follow-up study

    Imai E., Horio M., Yamagata K., Iseki K., Hara S., Ura N., Kiyohara Y., Makino H., Hishida A., Matsuo S.

    Hypertension Research   31 巻 ( 3 ) 頁: 433 - 441   2008年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Hypertension Research  

    The prevalence of stage 3 to 5 chronic kidney disease (CKD) in Japan (18.7%) is considerably higher than that in the United States (4.5%). This study investigated in the Japanese general population whether this higher prevalence of CKD might reflect to a progressive decline of renal function, and in turn to the increased risk of end-stage renal disease. A decline in renal function over 10 years was examined in 120,727 individuals aged 40 years or older who participated in the annual health examination program of the two periods over 10 years, 1988-1993 and 1998-2003. Renal function was assessed with estimated glomerular filtration rate (GFR) using the abbreviated Modification of Diet in Renal Disease (MDRD) Study equation modified by a Japanese coefficient. The rate of GFR decline in the participants was 0.36 mL/min/1.73 m2/ year on average. In the male population aged 50-79, the mean rate of GFR decline was significantly higher in the presence of hypertension than in its absence. The rate of GFR decline was more than two times higher in participants with proteinuria than in those without proteinuria in both sexes. The rate was significantly higher in participants with an initial GFR <50 mL/min/1.73 m2 among the groups younger than age 70 and in participants with an initial GFR <40 mL/min/1.73 m2 in the group with age 70-79. Based on the slow rate of GFR decline, we concluded that the decline in renal function progresses slowly in the Japanese general population. Hypertension, proteinuria and lower GFR were found to be significant risk factors for a faster decline of GFR.

    DOI: 10.1291/hypres.31.433

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  74. Chronic kidney disease perspectives in Japan and the importance of urinalysis screening

    Yamagata Kunihiro, Iseki Kunitoshi, Nitta Kousaku, Imai Hirokazu, Iino Yasuhiko, Matsuo Seiichi, Makino Hirofumi, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   12 巻 ( 1 ) 頁: 1 - 8   2008年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-007-0010-9

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  75. Modification of the Modification of Diet in Renal Disease (MDRD) Study equation for Japan

    Imai Enyu, Horio Masaru, Nitta Kosaku, Yamagata Kunihiro, Iseki Kunitoshi, Tsukamoto Yusuke, Ito Sadayoshi, Makino Hirofumi, Hishida Akira, Matsuo Seiichi

    AMERICAN JOURNAL OF KIDNEY DISEASES   50 巻 ( 6 ) 頁: 927 - 937   2007年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Journal of Kidney Diseases  

    DOI: 10.1053/j.ajkd.2007.09.004

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  76. Kidney disease screening program in japan: History, outcome, and perspectives

    Imai Enyu, Yamagata Kunihiro, Iseki Kunitoshi, Iso Hiroyasu, Horio Masaru, Mkino Hirofumi, Hishida Akira, Matsuo Seiichi

    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   2 巻 ( 6 ) 頁: 1360 - 1366   2007年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical Journal of the American Society of Nephrology  

    DOI: 10.2215/CJN.00980207

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  77. Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy.

    Zembutsu H, Yanada M, Hishida A, Katagiri T, Tsuruo T, Sugiura I, Takeuchi J, Usui N, Naoe T, Nakamura Y, Ohno R

    International journal of oncology   31 巻 ( 2 ) 頁: 313 - 22   2007年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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    PubMed

  78. Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy

    Zembutsu Hitoshi, Yanada Masamitsu, Hishida Asahi, Katagiri Toyomasa, Tsuruo Takashi, Sugiura Isamu, Takeuchi Jin, Usui Noriko, Naoe Tomoki, Nakamura Yusuke, Ohno Ryuzo

    INTERNATIONAL JOURNAL OF ONCOLOGY   31 巻 ( 2 ) 頁: 313 - 322   2007年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  79. Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy

    Zembutsu H.

    International Journal of Oncology   31 巻 ( 2 ) 頁: 313 - 322   2007年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Oncology  

    DOI: 10.3892/ijo.31.2.313

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  80. Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient

    Imai E.

    Clinical and Experimental Nephrology   11 巻 ( 2 ) 頁: 156 - 163   2007年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-007-0463-x

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  81. Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease

    Imai E.

    Clinical and Experimental Nephrology   11 巻 ( 1 ) 頁: 41 - 50   2007年3月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-006-0453-4

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  82. Associations between serum C-reactive protein (CRP) levels and polymorphisms of CRP, interleukin 1B, and tumor necrosis factor genes among Japanese health checkup examinees.

    Kikuchi M, Hishida A, Ishikawa K, Sagawa H, Suzuki K, Ito Y, Terasaki H, Hamajima N

    Asian Pacific journal of cancer prevention : APJCP   8 巻 ( 1 ) 頁: 87 - 92   2007年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  83. Associations between serum C-reactive Protein (CRP) Levels and Polymorphisms of CRP, Interleukin 1B, and tumor necrosis factor genes among Japanese health checkup examinees

    Kikuchi M.

    Asian Pacific Journal of Cancer Prevention   8 巻 ( 1 ) 頁: 87 - 92   2007年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Asian Pacific Journal of Cancer Prevention  

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  84. Associations between serum C-reactive protein (CRP) levels and polymorphisms of CRP, interleukin 1B, and tumor necrosis factor genes among Japanese health checkup examinees

    Kikuchi Masato, Hishida Asahi, Ishikawa Kohei, Sagawa Hiroe, Suzuki Koji, Ito Yoshinori, Terasaki Hiroko, Hamajima Nobuyuki

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   8 巻 ( 1 ) 頁: 87 - 92   2007年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  85. BMI-1 overexpression in 32Dcl3 cells suppresses granulocytic differentiation and ameliorates their growth under IL-3 diminished conditions.

    Hishida A, Yamamoto K, Sawa M, Naoe T

    BLOOD   106 巻 ( 11 ) 頁: 133B - 133B   2005年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  86. GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese.

    Hishida A, Terakura S, Emi N, Yamamoto K, Murata M, Nishio K, Sekido Y, Niwa T, Hamajima N, Naoe T

    Asian Pacific journal of cancer prevention : APJCP   6 巻 ( 3 ) 頁: 251 - 5   2005年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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    PubMed

  87. Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese.

    Tanaka D.

    Nagoya journal of medical science   67 巻 ( 3-4 ) 頁: 117 - 124   2005年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya journal of medical science  

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  88. Transcriptional induction of Smurf2 ubiquitin ligase by TGF-β

    Ohashi N., Yamamoto T., Uchida C., Togawa A., Fukasawa H., Fujigaki Y., Suzuki S., Kitagawa K., Hattori T., Oda T., Hayashi H., Hishida A., Kitagawa M.

    FEBS Letters   579 巻 ( 12 ) 頁: 2557 - 2563   2005年5月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:FEBS Letters  

    Smad ubiquitination regulatory factor 2 (Smurf2), a ubiquitin ligase for Smads, plays critical roles in the regulation of transforming growth factor-β (TGF-β)-Smad signaling via ubiquitin-dependent degradation of Smad2 and Smad7. We found that TGF-β stimulates Smurf2 expression. TGF-β activated the Smurf2 promoter in a TGF-β responsive cell lines, whereas IL-1α, PDGF and epidermal growth factor did not. TGF-β-mediated Smurf2 promoter activation was inhibited by Smad7 or an activin receptor-like kinase 5 inhibitor but not by dominant negative Smad or disruption of Smad-binding elements in the promoter. Moreover, inhibition of the phosphatidil inositol 3 kinase (PI3K)/Akt pathway suppressed TGF-β-mediated Smurf2 induction. These results suggest that TGF-β stimulates Smurf2 expression by Smad-independent pathway such as PI3K/Akt pathway via TGF-β receptor. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.febslet.2005.03.069

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  89. GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese

    Hishida A.

    Asian Pacific Journal of Cancer Prevention   6 巻 ( 3 ) 頁: 251 - 255   2005年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Asian Pacific Journal of Cancer Prevention  

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  90. A randomized open-label comparative study of conventional therapy versus mizoribine onlay therapy in patients with steroid-resistant nephrotic syndrome (postmarketing survey)

    Shibasaki T.

    Clinical and Experimental Nephrology   8 巻 ( 2 ) 頁: 117 - 126   2004年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-004-0276-0

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  91. Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma.

    Hishida A, Matsuo K, Hamajima N, Ito H, Ogura M, Kagami Y, Taji H, Morishima Y, Emi N, Tajima K

    Haematologica   88 巻 ( 2 ) 頁: 159 - 66   2003年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  92. Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma

    Hishida A, Matsuo K, Hamajima N, Ito H, Ogura M, Kagami Y, Taji H, Morishima Y, Emi N, Tajima K

    HAEMATOLOGICA   88 巻 ( 2 ) 頁: 159 - 166   2003年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  93. Sex-specific Relationship between Stress Coping Strategies and All-Cause Mortality: Japan Multi-Institutional Collaborative Cohort Study.

    Nagayoshi M, Takeuchi K, Tamada Y, Yasufumi K, Kubo Y, Okada R, Tamura T, Hishida A, Otonari J, Ikezaki H, Nishida Y, Shimanoe C, Koyanagi YN, Matsuo K, Haruo M, Miho K, Nishimoto D, Shibuya K, Suzuki S, Nishiyama T, Ozaki E, Watanabe I, Kuriki K, Takashima N, Kadota A, Arisawa K, Katsuura-Kamano S, Wakai K

    Journal of epidemiology     2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2188/jea.JE20210220

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  94. Differential Effect of Polymorphisms on Body Mass Index Across the Life Course of Japanese: The Japan Multi-Institutional Collaborative Cohort Study. 査読有り

    Iwase M, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, Ugai T, Kasugai Y, Hishida A, Takeuchi K, Okada R, Kubo Y, Shimanoe C, Tanaka K, Ikezaki H, Murata M, Takezaki T, Nishimoto D, Kuriyama N, Ozaki E, Suzuki S, Watanabe M, Mikami H, Nakamura Y, Uemura H, Katsuura-Kamano S, Kuriki K, Kita Y, Takashima N, Nagino M, Momozawa Y, Kubo M, Wakai K

    Journal of epidemiology   31 巻 ( 3 ) 頁: 172 - 179   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Epidemiology  

    DOI: 10.2188/jea.JE20190296

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  95. Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer. 査読有り

    Usui Y, Matsuo K, Oze I, Ugai T, Koyanagi Y, Maeda Y, Ito H, Hishida A, Takeuchi K, Tamura T, Tsukamoto M, Kadomatsu Y, Hara M, Nishida Y, Shimoshikiryo I, Takezaki T, Ozaki E, Matsui D, Watanabe I, Suzuki S, Watanabe M, Nakagawa-Senda H, Mikami H, Nakamura Y, Arisawa K, Uemura H, Kuriki K, Takashima N, Kadota A, Ikezaki H, Murata M, Nakatochi M, Momozawa Y, Kubo M, Wakai K

    Journal of epidemiology   31 巻 ( 1 ) 頁: 12 - 20   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Epidemiology  

    DOI: 10.2188/jea.JE20190184

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  96. ストレス対処行動とがん死亡リスクとの関係 J-MICC Study

    永吉 真子, 塚本 峰子, 久保 陽子, 岡田 理恵子, 田村 高志, 菱田 朝陽, 竹内 研時, 若井 建志

    Journal of Epidemiology   31 巻 ( Suppl. ) 頁: 115 - 115   2021年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本疫学会  

  97. 炭水化物・脂質摂取量と全死亡との関連 日本多施設共同コーホート研究(J-MICC Study)

    田村 高志, 門松 由佳, 塚本 峰子, 久保 陽子, 岡田 理恵子, 永吉 真子, 菱田 朝陽, 竹内 研時, 若井 建志

    Journal of Epidemiology   31 巻 ( Suppl. ) 頁: 95 - 95   2021年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本疫学会  

  98. 精神的健康度とストレス対処行動との関連

    塚本 峰子, 久保 陽子, 永吉 真子, 岡田 理恵子, 篠壁 多恵, 川合 紗世, 田村 高志, 菱田 朝陽, 竹内 研時, 若井 建志

    Journal of Epidemiology   31 巻 ( Suppl. ) 頁: 122 - 122   2021年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本疫学会  

  99. Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study.

    Koyama T, Kuriyama N, Ozaki E, Tomida S, Uehara R, Nishida Y, Shimanoe C, Hishida A, Tamura T, Tsukamoto M, Kadomatsu Y, Oze I, Matsuo K, Mikami H, Nakamura Y, Ibusuki R, Takezaki T, Suzuki S, Nishiyama T, Kuriki K, Takashima N, Kadota A, Uemura H, Katsuura-Kamano S, Ikezaki H, Murata M, Takeuchi K, Wakai K, Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group.

    Journal of atherosclerosis and thrombosis   27 巻 ( 10 ) 頁: 1097 - 1107   2020年10月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.5551/jat.54320

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  100. 日本人における緑茶と大腸がん罹患リスク JACC Studyのデータより(Green tea consumption and the risk of colorectal cancers in Japanese: data from the JACC Study)

    菱田 朝陽, 若井 建志, 玉腰 暁子, JACC Study Group

    日本癌学会総会記事   79回 巻   頁: OE24 - 2   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本癌学会  

  101. Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study.

    Takeuchi K, Naito M, Kawai S, Tsukamoto M, Kadomatsu Y, Kubo Y, Okada R, Nagayoshi M, Tamura T, Hishida A, Nakatochi M, Sasakabe T, Hashimoto S, Eguchi H, Momozawa Y, Ikezaki H, Murata M, Furusyo N, Tanaka K, Hara M, Nishida Y, Matsuo K, Ito H, Oze I, Mikami H, Nakamura Y, Kusakabe M, Takezaki T, Ibusuki R, Shimoshikiryo I, Suzuki S, Nishiyama T, Watanabe M, Koyama T, Ozaki E, Watanabe I, Kuriki K, Kita Y, Ueshima H, Matsui K, Arisawa K, Uemura H, Katsuura-Kamano S, Nakamura S, Narimatsu H, Hamajima N, Tanaka H, Wakai K

    Journal of epidemiology     2020年9月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.2188/jea.JE20200147

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  102. Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study. 査読有り 国際誌

    Arisawa K, Katsuura-Kamano S, Uemura H, Tien NV, Hishida A, Tamura T, Kubo Y, Tsukamoto M, Tanaka K, Hara M, Takezaki T, Nishimoto D, Koyama T, Ozaki E, Suzuki S, Nishiyama T, Kuriki K, Kadota A, Takashima N, Ikezaki H, Murata M, Oze I, Matsuo K, Mikami H, Nakamura Y, Takeuchi K, Wakai K

    Nutrients   12 巻 ( 6 )   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nutrients  

    DOI: 10.3390/nu12061605

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  103. Subtype-specific gout susceptibility loci and enrichment of selection pressure on <i>ABCG2</i> and <i>ALDH2</i> identified by subtype genome-wide meta-analyses of clinically defined gout patients.

    Nakayama A, Nakatochi M, Kawamura Y, Yamamoto K, Nakaoka H, Shimizu S, Higashino T, Koyama T, Hishida A, Kuriki K, Watanabe M, Shimizu T, Ooyama K, Ooyama H, Nagase M, Hidaka Y, Matsui D, Tamura T, Nishiyama T, Shimanoe C, Katsuura-Kamano S, Takashima N, Shirai Y, Kawaguchi M, Takao M, Sugiyama R, Takada Y, Nakamura T, Nakashima H, Tsunoda M, Danjoh I, Hozawa A, Hosomichi K, Toyoda Y, Kubota Y, Takada T, Suzuki H, Stiburkova B, Major TJ, Merriman TR, Kuriyama N, Mikami H, Takezaki T, Matsuo K, Suzuki S, Hosoya T, Kamatani Y, Kubo M, Ichida K, Wakai K, Inoue I, Okada Y, Shinomiya N, Matsuo H, Japan Gout Genomics Consortium (Japan Gout).

    Annals of the rheumatic diseases   79 巻 ( 5 ) 頁: 657 - 665   2020年5月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/annrheumdis-2019-216644

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  104. Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study. 査読有り

    Okada R, Kadomatsu Y, Tsukamoto M, Sasakabe T, Kawai S, Tamura T, Hishida A, Ikezaki H, Furusyo N, Tanaka K, Hara M, Suzuki S, Watanabe M, Takezaki T, Nishimoto D, Matsui D, Watanabe I, Kuriki K, Takashima N, Nakamura Y, Katsuura-Kamano S, Arisawa K, Mikami H, Nakamura Y, Oze I, Koyanagi YN, Naito M, Wakai K, Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

    Journal of human hypertension   34 巻 ( 2 ) 頁: 125 - 131   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Human Hypertension  

    DOI: 10.1038/s41371-019-0230-y

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  105. Associations between diet and mental health using the 12-item General Health Questionnaire: cross-sectional and prospective analyses from the Japan Multi-Institutional Collaborative Cohort Study. 査読有り 国際誌

    Choda N, Wakai K, Naito M, Imaeda N, Goto C, Maruyama K, Kadomatsu Y, Tsukamoto M, Sasakabe T, Kubo Y, Okada R, Kawai S, Tamura T, Hishida A, Takeuchi K, Mori A, Hamajima N

    Nutrition journal   19 巻 ( 1 ) 頁: 2 - 2   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nutrition Journal  

    DOI: 10.1186/s12937-019-0515-6

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  106. The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population.

    Nishida Y, Hachiya T, Hara M, Shimanoe C, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Tsukamoto M, Kadomatsu Y, Oze I, Koyanagi YN, Kuriyama N, Koyama T, Ibusuki R, Takezaki T, Ikezaki H, Furusyo N, Takashima N, Kadota A, Uemura H, Katsuura-Kamano S, Suzuki S, Nakagawa-Senda H, Kuriki K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K, Japan Multi-Institutional Collaborative Cohort Study Group.

    Journal of lipid research   61 巻 ( 1 ) 頁: 86 - 94   2020年1月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1194/jlr.P091546

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  107. A risk score predicting new incidence of hypertension in Japan. 査読有り

    Kadomatsu Y, Tsukamoto M, Sasakabe T, Kawai S, Naito M, Kubo Y, Okada R, Tamura T, Hishida A, Mori A, Hamajima N, Yokoi K, Wakai K

    Journal of human hypertension   33 巻 ( 10 ) 頁: 748 - 755   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Human Hypertension  

    DOI: 10.1038/s41371-019-0226-7

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  108. Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. 査読有り 国際誌

    Kawamura Y, Nakaoka H, Nakayama A, Okada Y, Yamamoto K, Higashino T, Sakiyama M, Shimizu T, Ooyama H, Ooyama K, Nagase M, Hidaka Y, Shirahama Y, Hosomichi K, Nishida Y, Shimoshikiryo I, Hishida A, Katsuura-Kamano S, Shimizu S, Kawaguchi M, Uemura H, Ibusuki R, Hara M, Naito M, Takao M, Nakajima M, Iwasawa S, Nakashima H, Ohnaka K, Nakamura T, Stiburkova B, Merriman TR, Nakatochi M, Ichihara S, Yokota M, Takada T, Saitoh T, Kamatani Y, Takahashi A, Arisawa K, Takezaki T, Tanaka K, Wakai K, Kubo M, Hosoya T, Ichida K, Inoue I, Shinomiya N, Matsuo H

    Annals of the rheumatic diseases   78 巻 ( 10 ) 頁: 1430 - 1437   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Annals of the Rheumatic Diseases  

    DOI: 10.1136/annrheumdis-2019-215521

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  109. 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. 査読有り

    Takata R, Takahashi A, Fujita M, Momozawa Y, Saunders EJ, Yamada H, Maejima K, Nakano K, Nishida Y, Hishida A, Matsuo K, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Sasaki M, Shimizu A, Tanno K, Minegishi N, Suzuki K, Matsuda K, Kubo M, Inazawa J, Egawa S, Haiman CA, Ogawa O, Obara W, Kamatani Y, Akamatsu S, Nakagawa H

    Nature communications   10 巻 ( 1 ) 頁: 4422   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nature Communications  

    DOI: 10.1038/s41467-019-12267-6

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  110. Polymorphisms in <i>CPT1B</i> and <i>CPT2</i> have no significant effect on plasma carnitine levels in Japanese cancer patients. 査読有り

    Hishida A, Watanabe R, Hattori Y, Okugawa Y, Shirai Y, Miki C

    Nagoya journal of medical science   81 巻 ( 3 ) 頁: 477 - 487   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

    DOI: 10.18999/nagjms.81.3.477

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  111. GWAS analysis reveals a significant contribution of PSCA to the risk of Heliobacter pylori-induced gastric atrophy. 査読有り

    Hishida A, Ugai T, Fujii R, Nakatochi M, Wu MC, Ito H, Oze I, Tajika M, Niwa Y, Nishiyama T, Nakagawa-Senda H, Suzuki S, Koyama T, Matsui D, Watanabe Y, Kawaguchi T, Matsuda F, Momozawa Y, Kubo M, Naito M, Matsuo K, Wakai K

    Carcinogenesis   40 巻 ( 5 ) 頁: 661 - 668   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Carcinogenesis  

    DOI: 10.1093/carcin/bgz016

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  112. 日本人121,745人を対象としたゲノムワイドメタ解析により血清尿酸値と関連する8つの新規遺伝子座を同定した

    中杤 昌弘, 松尾 洋孝, 中山 昌喜, 河村 優輔, 清水 聖子, 川口 真, 高尾 幹也, 四ノ宮 成祥, 金井 仁弘, 菱田 朝陽, 中村 好宏, 久保 充明, 鎌谷 洋一郎, 横田 充弘, 若井 建志, 岡田 随象

    痛風と尿酸・核酸   43 巻 ( 1 ) 頁: 31 - 31   2019年7月

  113. Association of genetic risk score and chronic kidney disease in a Japanese population. 査読有り

    Fujii R, Hishida A, Nakatochi M, Furusyo N, Murata M, Tanaka K, Shimanoe C, Suzuki S, Watanabe M, Kuriyama N, Koyama T, Takezaki T, Shimoshikiryo I, Arisawa K, Katsuura-Kamano S, Takashima N, Turin TC, Kuriki K, Endoh K, Mikami H, Nakamura Y, Oze I, Ito H, Kubo M, Momozawa Y, Kondo T, Naito M, Wakai K

    Nephrology (Carlton, Vic.)   24 巻 ( 6 ) 頁: 670 - 673   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nephrology  

    DOI: 10.1111/nep.13479

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  114. Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population. 査読有り

    Fujii R, Hishida A, Suzuki K, Imaeda N, Goto C, Hamajima N, Wakai K, Kondo T

    The British journal of nutrition   121 巻 ( 11 ) 頁: 1215 - 1222   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:British Journal of Nutrition  

    DOI: 10.1017/S0007114519000679

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  115. Associations of Nutrient Patterns with the Prevalence of Metabolic Syndrome: Results from the Baseline Data of the Japan Multi-Institutional Collaborative Cohort Study. 査読有り 国際誌

    Iwasaki Y, Arisawa K, Katsuura-Kamano S, Uemura H, Tsukamoto M, Kadomatsu Y, Okada R, Hishida A, Tanaka K, Hara M, Takezaki T, Shimatani K, Ozaki E, Koyama T, Suzuki S, Nakagawa-Senda H, Kuriki K, Miyagawa N, Kadota A, Ikezaki H, Furusyo N, Oze I, Ito H, Mikami H, Nakamura Y, Wakai K

    Nutrients   11 巻 ( 5 )   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nutrients  

    DOI: 10.3390/nu11050990

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  116. Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population. 査読有り

    Hirokazu Uemura, Sakurako Katsuura-Kamano, Yuki Iwasaki, Kokichi Arisawa, Asahi Hishida, Rieko Okada, Takashi Tamura, Yoko Kubo, Hidemi Ito, Isao Oze, Chisato Shimanoe, Yuichiro Nishida, Yasuyuki Nakamura, Naoyuki Takashima, Sadao Suzuki, Hiroko Nakagawa-Senda, Daisaku Nishimoto, Toshiro Takezaki, Haruo Mikami, Yohko Nakamura, Norihiro Furusyo, Hiroaki Ikezaki, Etsuko Ozaki, Teruhide Koyama, Kiyonori Kuriki, Kaori Endoh, Mariko Naito, Kenji Wakai

    Endocrine   64 巻 ( 3 ) 頁: 552 - 563   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endocrine  

    Our results suggest that higher daily life activity and higher moderate-intensity exercise may be independently associated with a lower risk of metabolic syndrome in Japanese adults.

    DOI: 10.1007/s12020-019-01926-9

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  117. Coffee consumption and liver cancer risk in Japan: a meta-analysis of six prospective cohort studies.

    Tamura T, Hishida A, Wakai K

    Nagoya journal of medical science   81 巻 ( 1 ) 頁: 143 - 150   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

    DOI: 10.18999/nagjms.81.1.143

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  118. Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care. 査読有り

    Hishida A, Okugawa Y, Morimoto Y, Shirai Y, Okamoto K, Momokita S, Ogawa A, Tanaka K, Nishikawa R, Toiyama Y, Inoue Y, Sakurai H, Urata H, Tanaka M, McMillan DC, Miki C

    Oncology letters   17 巻 ( 1 ) 頁: 623 - 629   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oncology Letters  

    DOI: 10.3892/ol.2018.9614

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  119. 日本人121,745人を対象としたゲノムワイドメタ解析により血清尿酸値と関連する8つの新規遺伝子座を同定した

    中杤 昌弘, 松尾 洋孝, 中山 昌喜, 河村 優輔, 清水 聖子, 川口 真, 高尾 幹也, 四ノ宮 成祥, 金井 仁弘, 菱田 朝陽, 中村 好宏, 久保 充明, 鎌谷 洋一郎, 横田 充弘, 若井 建志, 岡田 随象

    日本痛風・核酸代謝学会総会プログラム抄録集   52回 巻   頁: 75 - 75   2019年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本痛風・尿酸核酸学会  

  120. Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease: findings from the CKD-JAC study

    Nitta Kosaku, Iimuro Satoshi, Imai Enyu, Matsuo Seiichi, Makino Hirofumi, Akizawa Tadao, Watanabe Tsuyoshi, Ohashi Yasuo, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   23 巻 ( 1 ) 頁: 85 - 98   2019年1月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-018-1605-z

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  121. Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease: findings from the CKD-JAC study (vol 23, pg 85, 2018)

    Nitta Kosaku, Iimuro Satoshi, Imai Enyu, Matsuo Seiichi, Makino Hirofumi, Akizawa Tadao, Watanabe Tsuyoshi, Ohashi Yasuo, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   23 巻 ( 1 ) 頁: 99 - 99   2019年1月

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10157-018-1624-9

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  122. Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals. 査読有り

    Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Ichihara S, Akiyama M, Ikezaki H, Furusyo N, Shimizu S, Yamamoto K, Hirata M, Okada R, Kawai S, Kawaguchi M, Nishida Y, Shimanoe C, Ibusuki R, Takezaki T, Nakajima M, Takao M, Ozaki E, Matsui D, Nishiyama T, Suzuki S, Takashima N, Kita Y, Endoh K, Kuriki K, Uemura H, Arisawa K, Oze I, Matsuo K, Nakamura Y, Mikami H, Tamura T, Nakashima H, Nakamura T, Kato N, Matsuda K, Murakami Y, Matsubara T, Naito M, Kubo M, Kamatani Y, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H

    Communications biology   2 巻 ( 1 ) 頁: 115   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Communications Biology  

    DOI: 10.1038/s42003-019-0339-0

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  123. The association between self-rated health and high-sensitivity C-reactive protein level: a cross-sectional and 5-year longitudinal study.

    Tamura T, Naito M, Maruyama K, Tsukamoto M, Sasakabe T, Okada R, Kawai S, Hishida A, Wakai K

    BMC public health   18 巻 ( 1 ) 頁: 1380   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s12889-018-6251-6

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  124. The association of PSCA gene and H. pylori-related gastric atrophy risk detected by GWAS and SKAT

    Hishida Asahi, Fujii Ryosuke, Nakatochi Masahiro, Kawai Sayo, Ito Hidemi, Matsuo Keitaro, Watanabe Miki, Suzuki Sadao, Kuriyama Nagato, Naito Mariko, Wakai Kenji

    CANCER SCIENCE   109 巻   頁: 774-774   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  125. Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults. 査読有り

    Hara M, Hachiya T, Sutoh Y, Matsuo K, Nishida Y, Shimanoe C, Tanaka K, Shimizu A, Ohnaka K, Kawaguchi T, Oze I, Matsuda F, Ito H, Kawai S, Hishida A, Okada R, Sasakabe T, Hirata A, Ibusuki R, Nindita Y, Furusyo N, Ikezaki H, Kuriyama N, Ozaki E, Mikami H, Nakamura Y, Suzuki S, Hosono A, Katsuura-Kamano S, Arisawa K, Kuriki K, Endoh K, Takashima N, Kadota A, Nakatochi M, Momozawa Y, Kubo M, Naito M, Wakai K

    Medicine and science in sports and exercise   50 巻 ( 12 ) 頁: 2433 - 2441   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Medicine and Science in Sports and Exercise  

    DOI: 10.1249/MSS.0000000000001712

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  126. Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21. 査読有り

    Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, Momozawa Y, Hirata M, Fuse N, Takai-Igarashi T, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Hishida A, Wakai K, Furusyo N, Murakami Y, Nakamura Y, Imoto I, Inazawa J, Oze I, Sato N, Tanioka F, Sugimura H, Hirose H, Yoshida T, Matsuo K, Kubo M, Matsuda K

    Cancer science   109 巻 ( 12 ) 頁: 4015 - 4024   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Cancer Science  

    DOI: 10.1111/cas.13815

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  127. The association of PSCA gene and H. pylori-related gastric atrophy risk detected by GWAS and SKAT 査読有り

    Hishida Asahi, Fujii Ryosuke, Nakatochi Masahiro, Kawai Sayo, Ito Hidemi, Matsuo Keitaro, Watanabe Miki, Suzuki Sadao, Kuriyama Nagato, Naito Mariko, Wakai Kenji

    CANCER SCIENCE   109 巻   頁: 774   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  128. 日本人における尿酸値のGWASメタ解析による8個の新規遺伝子座の同定

    中嶌 真由子, 中杤 昌弘, 金井 仁弘, 中山 昌喜, 菱田 朝陽, 河村 優輔, 青柳 有香, 久保 充明, 鎌谷 洋一郎, 横田 充弘, 若井 建志, 岡田 随象, 四ノ宮 成祥, 松尾 洋孝

    防衛衛生   66 巻 ( 別冊 ) 頁: 44 - 44   2018年12月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本防衛衛生学会  

  129. Polymorphisms in folic acid metabolism genes do not associate with cancer cachexia in Japanese gastrointestinal patients. 査読有り

    Morishita T, Hishida A, Okugawa Y, Morimoto Y, Shirai Y, Okamoto K, Momokita S, Ogawa A, Tanaka K, Nishikawa R, Toiyama Y, Inoue Y, Sakurai H, Urata H, Tanaka M, Miki C

    Nagoya journal of medical science   80 巻 ( 4 ) 頁: 529 - 539   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Nagoya Journal of Medical Science  

    DOI: 10.18999/nagjms.80.4.529

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  130. Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study. 査読有り

    Tamura T, Kadomatsu Y, Tsukamoto M, Okada R, Sasakabe T, Kawai S, Hishida A, Hara M, Tanaka K, Shimoshikiryo I, Takezaki T, Watanabe I, Matsui D, Nishiyama T, Suzuki S, Endoh K, Kuriki K, Kita Y, Katsuura-Kamano S, Arisawa K, Ikezaki H, Furusyo N, Koyanagi YN, Oze I, Nakamura Y, Mikami H, Naito M, Wakai K, Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

    Medicine   97 巻 ( 48 ) 頁: e13241   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Medicine (United States)  

    DOI: 10.1097/MD.0000000000013241

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  131. WEIGHT GAIN IN ADULTHOOD AND PARENTAL HYPERTENSION AS THE RISK OF HYPERTENSION: FROM THE J-MICC STUDY 査読有り

    JOURNAL OF HYPERTENSION   36 巻   頁: E320   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/01.hjh.0000549308.48751.e8

    Web of Science

  132. Clinical Burden of Modified Glasgow Prognostic Scale in Colorectal Cancer. 査読有り

    Okugawa Y, Shirai Y, Toiyama Y, Saigusa S, Hishida A, Yokoe T, Tanaka K, Tanaka M, Yasuda H, Fujikawa H, Hiro J, Kobayashi M, Araki T, Inoue Y, McMillan DC, Kusunoki M, Miki C

    Anticancer research   38 巻 ( 3 ) 頁: 1599 - 1610   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Anticancer Research  

    DOI: 10.21873/anticanres.12390

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  133. Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population 査読有り

    Seiki T, Naito M, Hishida A, Takagi S, Matsunaga T, Sasakabe T, Hattori Y, Kawai S, Okada R, Yin G, Hamajima N, Wakai K

    Gene   642 巻   頁: 172-177   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.gene.2017.11.031

    PubMed

  134. A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study 査読有り

    Nakagawa-Senda H, Hachiya T, Shimizu A, Hosono S, Oze I, Watanabe M, Matsuo K, Ito H, Hara M, Nishida Y, Endoh K, Kuriki K, Katsuura-Kamano S, Arisawa K, Nindita Y, Ibusuki R, Suzuki S, Hosono A, Mikami H, Nakamura Y, Takashima N, Nakamura Y, Kuriyama N, Ozaki E, Furusyo N, Ikezaki H, Nakatochi M, Sasakabe T, Kawai S, Okada R, Hishida A, Naito M, Wakai K, Momozawa Y, Kubo M, Tanaka H

    Sci Rep   8 巻 ( 1 ) 頁: 1493   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-018-19914-w

    PubMed

  135. A common variant of MAF/c-MAF, transcriptional factor gene in the kidney, is associated with gout susceptibility. 査読有り

    Higashino T, Matsuo H, Okada Y, Nakashima H, Shimizu S, Sakiyama M, Tadokoro S, Nakayama A, Kawaguchi M, Komatsu M, Hishida A, Nakatochi M, Ooyama H, Imaki J, Shinomiya N

    Human cell   31 巻 ( 1 ) 頁: 10 - 13   2018年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Human Cell  

    DOI: 10.1007/s13577-017-0186-6

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  136. Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglycerides by ALDH2 and ADH1B polymorphisms in Japanese men 査読有り

    Sasakabe T, Wakai K, Kawai S, Hishida A, Naito M, Suzuki S, Nindita Y, Arisawa K, Kita Y, Hara M, Kuriyama N, Hirata A, Mikami H, Oze I, Kubo M, Tanaka H, Hamajima N

    J Epidemiol   in press 巻   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2188/jea.JE20160189

    PubMed

  137. Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1. 査読有り

    Yodsurang V, Tang Y, Takahashi Y, Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Fuse N, Sugawara J, Shimizu A, Fukushima A, Hishida A, Furusyo N, Naito M, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Hirata M, Murakami Y, Kubo M, Matsuda K

    PloS one   13 巻 ( 12 ) 頁: e0209096   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PLoS ONE  

    DOI: 10.1371/journal.pone.0209096

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  138. A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression

    Shimanoe C, Hachiya T, Hara M, Nishida Y, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Kawai S, Okada R, Tamura T, Matsuo K, Ito H, Ozaki E, Matsui D, Ibusuki R, Shimoshikiryo I, Takashima N, Kadota A, Arisawa K, Uemura H, Suzuki S, Watanabe M, Kuriki K, Endoh K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K

    Genes Brain Behav   18 巻 ( 2 ) 頁: e12481   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Genes, Brain and Behavior  

    Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met sugg

    DOI: 10.1111/gbb.12481

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  139. Genetic variants of RAMP2 and CLR are associated with stroke 査読有り

    Koyama T, Kuriyama N, Ozaki E, Matsui D, Watanabe I, Takeshita W, Iwai K, Watanabe Y, Nakatochi M, Shimanoe C, Tanaka K, Oze I, Ito H, Uemura H, Katsuura-Kamano S, Ibusuki R, Shimoshikiryo I, Takashima N, Kadota A, Kawai S, Sasakabe T, Okada R, Hishida A, Naito M, Kuriki K, Endoh K, Furusyo N, Ikezaki H, Suzuki S, Hosono A, Mikami H, Nakamura Y, Kubo M, Wakai K

    J Atheroscler Thromb   24 巻 ( 12 ) 頁: 1267-1281   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.5551/jat.41517

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  140. Real-world experience of anti-tumor necrosis factor therapy for internal fistulas in crohn's disease: a retrospective multicenter cohort study 査読有り

    Kobayashi T, Hishida A, Tanaka H, Nuki Y, Bamba S, Yamada A, Fujii T, Shinzaki S, Yokoyama Y, Yoshida A, Ozeki K, Ashizuka S, Kamata N, Nanjo S, Kakimoto K, Nakamura M, Matsui A, Yamauchi R, Takahashi S, Tomizawa T, Yoshino T, Hibi T

    Inflamm Bowel Dis   23 巻 ( 12 ) 頁: 2245-2251   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1097/MIB.0000000000001276

    PubMed

  141. A panel of methylated microRNA biomarkers for identifying high-risk patients with ulcerative colitis-associated colorectal cancer 査読有り

    Toiyama Y, Okugawa Y, Tanaka K, Araki T, Uchida K, Hishida A, Uchino M, Ikeuchi H, Hirota S, Kusunoki M, Boland C R, Goel A

    Gastroenterology   153 巻 ( 6 ) 頁: 1634-1646   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1053/j.gastro.2017.08.037

    PubMed

  142. Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia 査読有り

    Shirai Y, Okugawa Y, Hishida A, Ogawa A, Okamoto K, Shintani M, Morimoto Y, Nishikawa R, Yokoe T, Tanaka K, Urata H, Toiyama Y, Inoue Y, Tanaka M, Mohri Y, Goel A, Kusunoki M, McMillan D C, Miki C

    Sci Rep   7 巻 ( 1 ) 頁: 4826   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-017-05278-0

    PubMed

  143. URAT1/SLC22A12遺伝子の機能消失型変異が血清尿酸値および痛風・高尿酸血症の発症に与える影響

    崎山 真幸, 松尾 洋孝, 清水 聖子, 中山 昌喜, 東野 俊英, 高田 龍平, 市田 公美, 大山 博司, 清水 徹, 四ノ宮 成祥, 中村 好宏, 内藤 真理子, 須磨 紫乃, 菱田 朝陽

    痛風と核酸代謝   41 巻 ( 1 ) 頁: 143 - 143   2017年7月

  144. URAT1/SLC22A12遺伝子の機能消失型変異が血清尿酸値および痛風・高尿酸血症の発症に与える影響

    崎山 真幸, 松尾 洋孝, 清水 聖子, 中山 昌喜, 東野 俊英, 高田 龍平, 市田 公美, 大山 博司, 清水 徹, 四ノ宮 成祥, 中村 好宏, 内藤 真理子, 須磨 紫乃, 菱田 朝陽

    日本痛風・核酸代謝学会総会プログラム抄録集   50回 巻   頁: 202 - 202   2017年2月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本痛風・尿酸核酸学会  

  145. Objective predictive score as a feasible biomarker for short-term survival in terminalIy Ill patients with cancer 査読有り

    Okugawa Y, Shirai Y, Nodono H, Matsutani F, Itoh M, Hishida A, Morimoto Y, Nishikawa R, Yokoe T, Tanaka K, Urata H, Toiyama Y, Araki T, Inoue Y, Tanaka M, Kusunoki M, Miki C

    Anticancer Res   37 巻 ( 1 ) 頁: 267-275   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.21873/anticanres.11317

    PubMed

  146. Response to the letter to the editor: Metallothionein MT2A A-5G polymorphism and the risk for chronic kidney disease and diabetes. 査読有り

    Hattori Y, Naito M, Satoh M, Nakatochi M, Naito H, Kato M, Takagi S, Matsunaga T, Seiki T, Sasakabe T, Suma S, Kawai S, Okada R, Hishida A, Hamajima N, Wakai K

    Toxicological sciences : an official journal of the Society of Toxicology   154 巻 ( 2 ) 頁: 198 - 199   2016年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/toxsci/kfw205

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  147. 大腸 免疫療法の進化 消化器がん患者に対する免疫栄養療法の有用性の検討

    白井 由美子, 奥川 喜永, 菱田 朝陽, 新谷 実希, 小川 亜希, 福迫 朝子, 岡本 京子, 小澤 一夫, 福森 和俊, 田中 光司, 田中 基幹, 三木 誓雄

    日本癌治療学会学術集会抄録集   54回 巻   頁: MS62 - 4   2016年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本癌治療学会  

  148. 大腸癌におけるmGPSのpatient selection markerとしての有用性と、体組成計を用いたEPA栄養療法の有効性

    奥川 喜永, 問山 裕二, 田中 光司, 白井 由美子, 菱田 朝陽, 小川 亜希, 小澤 一夫, 森本 雄貴, 西川 隆太郎, 濱口 哲也, 浦田 久志, 田中 基幹, 藤川 裕之, 廣 純一郎, 井上 靖浩, 毛利 靖彦, 三木 誓雄, 楠 正人

    日本大腸肛門病学会雑誌   69 巻 ( 抄録号 ) 頁: A152 - A152   2016年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:(一社)日本大腸肛門病学会  

  149. サイトカイン遺伝子多型の緩和期消化器がん患者の生命予後に与える影響

    菱田 朝陽, 奥川 喜永, 田中 基幹, 三木 誓雄

    日本癌学会総会記事   75回 巻   頁: P - 3338   2016年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本癌学会  

  150. The effects of URAT1/SLC22A12 nonfunctional variants,R90H and W258X, on serum uric acid levels and gout/hyperuricemia progression 査読有り

    Sakiyama M, Matsuo H, Shimizu S, Nakashima H, Nakamura T, Nakayama A, Higashino T, Naito M, Suma S, Hishida A, Satoh T, Sakurai Y, Takada T, Ichida K, Ooyama H, Shimizu T, Shinomiya N

    Sci Rep   6 巻   頁: 20148   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/srep20148

    PubMed

  151. 森林散策頻度と高血圧症との関連:名古屋市民での検討

    森田 えみ, 内藤 真理子, 高木 咲穂子, 松永 貴史, 清木 俊雄, 篠壁 多恵, 服部 雄太, 岡田 理恵子, 川合 紗世, 菱田 朝陽, 浜島 信之, 若井 建志

    日本森林学会大会発表データベース   127 巻   頁: 772 - 772   2016年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:日本森林学会  

    【目的】1回数時間の森林浴をした場合,血圧が低下することが報告されている。一般的に健康への効果を期待するには継続して行う必要がある。静岡県の人間ドック受診者を対象にした研究では,森林散策頻度と高血圧症には関連が見られないことを報告したが,集団が異なると結果が異なることも多い。よって本研究では,名古屋市民にて森林散策頻度と高血圧症との関連を検証した。【方法】解析対象は名古屋市の一般住民5,132人(男性1,458人,女性3,672人,平均年齢52.5±10.3歳,35~69歳)とし,高血圧症は,降圧剤の服薬,収縮期血圧140mmHg以上,拡張期血圧90mmHg以上のいずれかに当てはまる人と定義した。従属変数を高血圧症,独立変数を年齢,飲酒,喫煙,BMI,運動習慣,森林散策頻度として,男女別にロジスティック回帰分析を行った。【結果及び考察】年齢調整後の高血圧症の割合は,森林散策頻度が週1回以上は26.0%,月2~3回は28.7%,月1回は21.4%,年数回以下は20.7%であった。森林散策頻度は,男女ともに高血圧症に対する調整オッズ比は有意ではなかった。静岡地区と同様に,高頻度で森林散策をしていても高血圧症の有病率は低くはなかった。

    DOI: 10.11519/jfsc.127.0_772

  152. Effects of IL6 C-634G polymorphism on tooth loss and their interaction with smoking habits 査読有り

    Suma S, Naito M, Wakai K, Sasakabe T, Hattori Y, Okada R, Kawai S, Hishida A, Morita E, Nakagawa H, Tamura T, Hamajima N

    Oral Dis   21 巻 ( 6 ) 頁: 807 - 813   2015年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Oral Diseases  

    DOI: 10.1111/odi.12352

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    その他リンク: http://orcid.org/0000-0002-4867-0201

  153. GGT1 intronic A>G polymorphism affects serum concentration of γ-glutamyltransferase among Japanese healthy adult. 査読有り

    S, Kawai, M, Naito, E, Morita, R, Okada, A, Hishida, K, Wakai, N, Hamajima

    Ningen Dock International   2 巻 ( 2 ) 頁: 7 - 11   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  154. Tumor intrinsic subtype is reflected in cancer-adjacent tissue 査読有り

    Casbas-Hernandez P, Sun X, Roman-Perez E, D'Arcy M, Sandhu R, Hishida A, McNaughton K K, Yang X i R, Makowski L, Sherman M E, Figueroa J D, Troester M A.

    Cancer Epidemiol Biomarkers Prev   24 巻 ( 2 ) 頁: 406-414   2015年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1158/1055-9965.EPI-14-0934

    PubMed

  155. No association between Helicobacter pylori infection and diabetes mellitus among a general Japanese population: a cross-sectional study. 査読有り

    Tamura T, Morita E, Kawai S, Sasakabe T, Sugimoto Y, Fukuda N, Suma S, Nakagawa H, Okada R, Hishida A, Naito M, Hamajima N, Wakai K

    SpringerPlus   4 巻 ( 1 ) 頁: 602   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SpringerPlus  

    DOI: 10.1186/s40064-015-1371-2

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  156. GGT1 intronic A>G polymorphism affects setum concentration of γ-glutamyl transpeptidase among Japanese healthy adults 査読有り

    Kawai S, Naito M, Morita E, Okada R, Hishida A, Wakai K, Hamajima N.

    Ningen Dock International   2 巻 ( 2 ) 頁: 65-69   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  157. GGT1 intronic A>G polymorphism affects setum concentration of gammma-glutamyl transpeptidase among Japanese healthy adults.

    Kawai S, Naito M, Morita E, Okada R, Hishida A, Wakai K, Hamajima N

    Ningen Dock International   2 巻   頁: 65 - 69   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  158. Common variant of PDZK1, adaptor protein gene of urate transporters, is not associated with gout. 査読有り

    Takada Y, Matsuo H, Nakayama A, Sakiyama M, Hishida A, Okada R, Sakurai Y, Shimizu T, Ichida K, Shinomiya N

    The Journal of rheumatology   41 巻 ( 11 ) 頁: 2330 - 1   2014年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Rheumatology  

    DOI: 10.3899/jrheum.140573

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  159. Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study. 査読有り

    Hishida A, Wakai K, Naito M, Suma S, Sasakabe T, Hamajima N, Hosono S, Horita M, Turin TC, Suzuki S, Kairupan TS, Mikami H, Ohnaka K, Watanabe I, Uemura H, Kubo M, Tanaka H, J-MICC Study Group.

    Lipids in health and disease   13 巻 ( 1 ) 頁: 162   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Lipids in Health and Disease  

    DOI: 10.1186/1476-511X-13-162

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  160. Validation of the General Oral Health Assessment (GOHAI) Index into Japanese adults 査読有り

    Mariko Naito, Yoshimi Suzukamo, Shino Suma, Sayo Kawai, Rieko Okada, Asahi Hishida, Emi Morita, Nobuyuki Hamajima, Kenji Wakai

    QUALITY OF LIFE RESEARCH   23 巻   頁: 173 - 173   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Web of Science

  161. Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population. 査読有り

    Hara M, Nakamura K, Nanri H, Nishida Y, Hishida A, Kawai S, Hamajima N, Kita Y, Suzuki S, Mantjoro EM, Ohnaka K, Uemura H, Matsui D, Oze I, Mikami H, Kubo M, Tanaka H, Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.

    Journal of epidemiology   24 巻 ( 5 ) 頁: 379 - 84   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Epidemiology  

    DOI: 10.2188/jea.je20140002

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  162. A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility 査読有り

    Nakayama Akiyoshi, Matsuo Hirotaka, Shimizu Takuya, Ogata Hiraku, Takada Yuzo, Nakashima Hiroshi, Nakamura Takahiro, Shimizu Seiko, Chiba Toshinori, Sakiyama Masayuki, Ushiyama Chisaki, Takada Tappei, Inoue Katsuhisa, Kawai Sayo, Hishida Asahi, Wakai Kenji, Hamajima Nobuyuki, Ichida Kimiyoshi, Sakurai Yutaka, Kato Yukio, Shimizu Toru, Shinomiya Nariyoshi

    HUMAN CELL   26 巻 ( 4 ) 頁: 133 - 136   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s13577-013-0073-8

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  163. Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study. 査読有り

    Hishida A, Okada R, Naito M, Morita E, Wakai K, Hamajima N, Hosono S, Nanri H, Turin TC, Suzuki S, Kuwabara K, Mikami H, Budhathoki S, Watanabe I, Arisawa K, Kubo M, Tanaka H

    Journal of clinical biochemistry and nutrition   53 巻 ( 1 ) 頁: 15 - 20   2013年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Clinical Biochemistry and Nutrition  

    DOI: 10.3164/jcbn.13-17

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  164. MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study. 査読有り

    Asahi Hishida, Rieko Okada, Yin Guang, Mariko Naito, Kenji Wakai, Satoyo Hosono, Kazuyo Nakamura, Chowdhury Tanvir Turin, Sadao Suzuki, Hideshi Niimura, Haruo Mikami, Jun Otonari, Nagato Kuriyama, Sakurako Katsuura, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima

    International Urology and Nephrology   45 巻 ( 6 ) 頁: 1613 - 20   2013年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Urology and Nephrology  

    PURPOSE: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the associations of MTHFR, MTR, and MTRR polymorphisms with the risk of CKD in Japanese, we examined this association among Japanese subjects using cross-sectional data. METHODS: The subjects for this analysis were 3,318 participants consecutively selected from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. The polymorphisms were genotyped by a multiplex polymerase chain reaction-based Invader assay. Age- and sex-adjusted odds ratio (aOR) of CKD with stage 3-5 was calculated for each genotype. RESULTS: When those with MTHFR C677T C/C were defined as references, those with MTHFR C677T C/T and T/T demonstrated the aORs for CKD of 1.14 (95 % CI 0.93-1.40) and 1.39 (1.06-1.82), respectively. Marginally significantly decreased risk of CKD with increasing number of MTR A2756G G allele (p = 0.058) was observed. Stratified analyses by plasma folate low (&lt;7.4 ng/ml) or high (?7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. CONCLUSIONS: The present study found a significant association between the subjects with the T/T genotype of MTHFR C677T polymorphism and the elevated risk of CKD, which may suggest the possibility of the risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.

    DOI: 10.1007/s11255-013-0432-0

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  165. Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of Type 2 DM in Japanese - the J-MICC Study [Rapid Communication] 査読有り

    Hishida A, Wakai K, Okada R, Morita E, Hamajima N, Hosono S, Higaki Y, Chowdhury Turin T, Suzuki S, Motahareh K, Mikami H, Tashiro N, Watanabe I, Katsuura S, Kubo M, Tanaka H, Naito M.

    Endocr J   60 巻 ( 2 ) 頁: 237-243   2013年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  166. Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study. 査読有り

    Hishida A, Wakai K, Naito M, Tamura T, Kawai S, Hamajima N, Oze I, Imaizumi T, Turin TC, Suzuki S, Kheradmand M, Mikami H, Ohnaka K, Watanabe Y, Arisawa K, Kubo M, Tanaka H

    PPAR research   2013 巻   頁: 980471   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PPAR Research  

    DOI: 10.1155/2013/980471

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  167. Common dysfunctional variants in ABCG2 are a major cause of early-onset gout. 査読有り

    Matsuo H, Ichida K, Takada T, Nakayama A, Nakashima H, Nakamura T, Kawamura Y, Takada Y, Yamamoto K, Inoue H, Oikawa Y, Naito M, Hishida A, Wakai K, Okada C, Shimizu S, Sakiyama M, Chiba T, Ogata H, Niwa K, Hosoyamada M, Mori A, Hamajima N, Suzuki H, Kanai Y, Sakurai Y, Hosoya T, Shimizu T, Shinomiya N

    Scientific reports   3 巻   頁: 2014   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Scientific Reports  

    DOI: 10.1038/srep02014

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  168. Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity. 査読有り

    Hiyoshi M, Uemura H, Arisawa K, Nakamoto M, Hishida A, Okada R, Matsuo K, Kita Y, Niimura H, Kuriyama N, Nanri H, Ohnaka K, Suzuki S, Mikami H, Kubo M, Tanaka H, Hamajima N, J-MICC Study Group.

    Gene   496 巻 ( 2 ) 頁: 97 - 102   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Gene  

    DOI: 10.1016/j.gene.2012.01.015

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  169. Prevalence of Helicobacter pylori infection measured with urinary antibody in an urban area of Japan, 2008-2010 査読有り

    Tamura T, Morita E, Kondo T, Ueyama J, Tanaka T, Kida Y, Hori Y, Inoue S, Tomita K, Okada R, Kawai S, Hishida A, Naito M, Wakai K, Hamajima N.

    Nagoya J Med Sci   74 巻 ( 1-2 ) 頁: 63-70   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PubMed

  170. Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study. 査読有り

    Hishida A, Morita E, Naito M, Okada R, Wakai K, Matsuo K, Nakamura K, Takashima N, Suzuki S, Takezaki T, Mikami H, Ohnaka K, Watanabe Y, Uemura H, Kubo M, Tanaka H, Hamajima N

    Endocrine journal   59 巻 ( 7 ) 頁: 589 - 99   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Endocrine Journal  

    DOI: 10.1507/endocrj.ej11-0310

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  171. Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease. 査読有り

    Okada R, Kawai S, Naito M, Hishida A, Hamajima N, Shinchi K, Chowdhury Turin T, Suzuki S, Mantjoro EM, Toyomura K, Arisawa K, Kuriyama N, Hosono S, Mikami H, Kubo M, Tanaka H, Wakai K, Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.

    American journal of nephrology   36 巻 ( 5 ) 頁: 444 - 50   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Journal of Nephrology  

    DOI: 10.1159/000343742

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  172. Association between KLK3 rs2735839 G/A polymorphism and serum PSA levels in Japanese men. 査読有り

    Nobata S, Hishida A, Naito M, Asai Y, Mori A, Kuwabara M, Katase S, Okada R, Morita E, Kawai S, Hamajima N, Wakai K

    Urologia internationalis   89 巻 ( 1 ) 頁: 39 - 44   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Urologia Internationalis  

    DOI: 10.1159/000332197

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  173. ASSOCIATION OF OBESITY AND DIABETES WITH SERUM PROSTATE-SPECIFIC ANTIGEN LEVELS IN JAPANESE MALES

    Naito, Mariko, Asai, Yatami, Mori, Atsuyoshi, Fukada, Yuko, Kuwabara, Mayumi, Katase, Shiro, Hishida, Asahi, Morita, Emi, Kawai, Sayo, Okada, Rieko, Nishio, Kazuko, Tamakoshi, Akiko, Wakai, Kenji, Hamajima, Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   74 巻 ( 3-4 ) 頁: 285 - 292   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  174. No association between the frequency of forest walking and blood pressure levels or the prevalence of hypertension in a cross-sectional study of a Japanese population. 査読有り

    Morita E, Naito M, Hishida A, Wakai K, Mori A, Asai Y, Okada R, Kawai S, Hamajima N

    Environmental health and preventive medicine   16 巻 ( 5 ) 頁: 299 - 306   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Environmental Health and Preventive Medicine  

    DOI: 10.1007/s12199-010-0197-3

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  175. Significant association of serum uric acid levels with SLC2A9 rs11722228 among a Japanese population 査読有り

    Hamajima N, Okada R, Kawai S, Hishida A, Morita E, Yin G, Wakai K, Matsuo H, Inoue H, Takada Y, Asai Y, Mori A, Naito M.

    Mol Genet Metab   103 巻 ( 4 ) 頁: 378-382   2011年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ymgme.2011.04.001

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  176. Study profile on baseline survey of Daiko Study in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) 査読有り

    Morita E, Hamajima N, Hishida A, Aoyama K, Okada R, Kawai S, Tomita K, Kuriki S, Tamura T, Naito M, Kondo T, Ueyama J, Kimata A, Yamamoto K, Hori Y, Hoshino J, Hamamoto R, Tsukamoto S, Onishi J, Hagikura S, Naito H, Hibi S, Ito Y, Wakai K.

    Nagoya J Med Sci   73 巻 ( 3-4 ) 頁: 187-195   2011年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PubMed

  177. ASSOCIATION BETWEEN THE RANK POLYMORPHISM AND THE NUMBER OF TEETH AMONG JAPANESE

    Naito M., Asai Y., Mori A., Kuwabara M., Okamoto A., Katase S., Hishida A., Morita E., Kawai S., Okada R., Wakai K., Hamajima N.

    JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH   65 巻   頁: A280 - A280   2011年8月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/jech.2011.142976j.45

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  178. Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study 査読有り

    Wakai K, Hamajima N, Okada R, Naito M, Morita E, Hishida A, Kawai S, Nishio K, Yin G, Asai Y, Matsuo K, Hosono S, Ito H, Watanabe M, Kawase T, Suzuki T, Tajima K, Tanaka K, Higaki Y, Hara M, Imaizumi T, Taguchi N, Nakamura K, Nanri H, Sakamoto T, Horita M, Shinchi K, Kita Y, Turin T C, Rumana N, Matsui K, Miura K, Ueshima H, Takashima N, Nakamura Y, Suzuki S, Ando R, Hosono A, Imaeda N, Shibata K, Goto C, Hattori N, Fukatsu M, Yamada T, Tokudome S, Takezaki T, Niimura H, Hirasada K, Nakamura A, Tatebo M, Ogawa S, Tsunematsu N, Chiba S, Mikami H, Kono S, Ohnaka K, Takayanagi R, Watanabe Y, Ozaki E, Shigeta M, Kuriyama N, Yoshikawa A, Matsui D, Watanabe I, Inoue K, Ozasa K, Mitani S, Arisawa K, Uemura H, Hiyoshi M, Takami H, Yamaguchi M, Nakamoto M, Takeda H, Kubo M, Tanaka H, for the J-MICC Study Group.

    J Epidemiol   21 巻 ( 3 ) 頁: 223-235   2011年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  179. Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4 +3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese. 査読有り

    Hishida A, Matsuo K, Goto Y, Naito M, Wakai K, Tajima K, Hamajima N

    Digestive diseases and sciences   56 巻 ( 4 ) 頁: 1131 - 7   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Digestive Diseases and Sciences  

    DOI: 10.1007/s10620-010-1376-1

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  180. Serum uric acid distribution according to SLC22A12 W258X genotype in a cross-sectional study of a general Japanese population 査読有り

    Hamajima N, Naito M, Hishida A, Okada R, Asai Y, Wakai K.

    BMC Med Genet   12 巻 ( 1 ) 頁: 33   2011年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/1471-2350-12-33

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  181. Association of UGT1A1 Gly71Arg with urine urobilinogen. 査読有り

    Kataoka R, Kimata A, Yamamoto K, Hirosawa N, Ueyama J, Kondo T, Okada R, Kawai S, Hishida A, Naito M, Morita E, Wakai K, Hamajima N

    Nagoya journal of medical science   73 巻 ( 1-2 ) 頁: 33 - 40   2011年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PubMed

  182. ASSOCIATION OF UGT1A1 GLY71ARG WITH URINE UROBILINOGEN

    Kataoka, Ryuji, Kimata, Akiko, Yamamoto, Kanami, Hirosawa, Naoko, Ueyama, Jun, Kondo, Takaaki, Okada, Rieko, Kawai, Sayo, Hishida, Asahi, Naito, Mariko, Morita, Emi, Wakai, Kenji, Hamajima, Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   73 巻 ( 1-2 ) 頁: 33 - 40   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  183. Combined effect of miR-146a rs2910164 G/C polymorphism 査読有り

    Hishida A, Matsuo K, Goto Y, Naito M, Wakai W, Tajima K, Hamajima N

    Dig Dis Sci   56 巻   頁: 1131-1137   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  184. STUDY PROFILE ON BASELINE SURVEY OF DAIKO STUDY IN THE JAPAN MULTI-INSTITUTIONAL COLLABORATIVE COHORT STUDY (J-MICC STUDY)

    Morita, Emi, Hamajima, Nobuyuki, Hishida, Asahi, Aoyama, Kyoko, Okada, Rieko, Kawai, Sayo, Tomita, Koutaro, Kuriki, Sayaka, Tamura, Takashi, Naito, Mariko, Kondo, Takaaki, Ueyama, Jun, Kimata, Akiko, Yamamoto, Kanami, Hori, Yoko, Hoshino, Junko, Hamamoto, Ritsuko, Tsukamoto, Sanae, Onishi, Joji, Hagikura, Shoichi, Naito, Hisao, Hibi, Satoshi, Ito, Yoshinori, Wakai, Kenji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   73 巻 ( 3-4 ) 頁: 187 - 195   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  185. No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese. 査読有り

    Hishida A, Matsuo K, Goto Y, Naito M, Wakai K, Tajima K, Hamajima N

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   13 巻 ( 4 ) 頁: 251 - 7   2010年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Gastric Cancer  

    DOI: 10.1007/s10120-010-0567-y

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  186. Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions. 査読有り

    Hishida A, Matsuo K, Goto Y, Hamajima N

    World journal of gastrointestinal oncology   2 巻 ( 10 ) 頁: 369 - 79   2010年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.4251/wjgo.v2.i10.369

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  187. 人間ドック受診者を対象とした静岡県中西部地区における森林散策頻度に関する大規模調査 査読有り

    森田えみ, 内藤真理子, 西尾和子, 石田喜子, 菱田朝陽, 若井建志, 浅井八多美, 浜島信之.

    日林誌   92 巻 ( 2 ) 頁: 110-114   2010年6月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  188. PRKCH gene polymorphism is associated with the risk of severe gastric atrophy 査読有り

    Goto Y, Hishida A, Matsuo K, Tajima K, Morita E, Naito M, Wakai K, Hamajima N.

    Gastric Cancer   13 巻 ( 2 ) 頁: 90-94   2010年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10120-009-0542-7

    PubMed

  189. Genetic traits for the persistence of Helicobacter pylori infection 査読有り

    Hamajima N, Hishida A.

    Personalized Med   7 巻 ( 3 ) 頁: 249-262   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  190. Genetic traits for the persistence of Helicobacter pylori infection. 査読有り

    Hamajima N, Hishida A

    Personalized medicine   7 巻 ( 3 ) 頁: 249 - 262   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Personalized Medicine  

    DOI: 10.2217/pme.10.14

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  191. Associations of plasma IL-8 levels with Helicobacter pylori seropositivity, gastric atrophy, and IL-8 T-251A genotypes

    Naito M., Eguchi H., Goto Y., Kondo T., Nishio K., Ishida Y., Kawai S., Okada R., Hishida A., Wakai K., Hamajima N.

    EPIDEMIOLOGY AND INFECTION   138 巻 ( 4 ) 頁: 512 - 518   2010年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Epidemiology and Infection  

    DOI: 10.1017/S0950268809990677

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  192. Association between circulating IL-8 levels, IL-8 T-251A genotypes and Helicobacter pylori infection 査読有り

    Naito M, Eguchi H, Goto Y, Kondo T, Nishio K, Ishida Y, Kawai S, Okada R, Hishida A, Wakai K, Hamajima N

    Epidemiol Infect   138 巻   頁: 512-518   2010年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  193. No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese. 査読有り

    Hishida A, Matsuo K, Goto Y, Mitsuda Y, Hiraki A, Naito M, Wakai K, Tajima K, Hamajima N

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   13 巻 ( 1 ) 頁: 43 - 9   2010年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Gastric Cancer  

    DOI: 10.1007/s10120-009-0534-7

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  194. Efficacy of genotype notification to Japanese smokers on smoking cessation--an intervention study at workplace. 査読有り

    Hishida A, Terazawa T, Mamiya T, Ito H, Matsuo K, Tajima K, Hamajima N

    Cancer epidemiology   34 巻 ( 1 ) 頁: 96 - 100   2010年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Cancer Epidemiology  

    DOI: 10.1016/j.canep.2009.11.008

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  195. Smoking behavior and risk of Helicobacter pylori infection, gastric atrophy and gastric cancer in Japanese 査読有り

    Hishida A, Matsuo K, Goto Y, Naito M, Wakai K, Tajima K, Hamajima N.

    Asian Pac J Cancer Prev   11 巻 ( 2 ) 頁: 313-317   2010年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    PubMed

  196. 人間ドック受診者を対象とした静岡県中西部地区における森林散策頻度に関する大規模調査.

    森田えみ, 内藤真理子, 西尾和子, 石田喜子, 菱田朝陽, 若井建志, 浅井八多美, 浜島信之

    日林誌   92 巻   頁: 110 - 114   2010年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  197. Smoking Behavior and Risk of Helicobacter Pylori Infection, Gastric Atrophy and Gastric Cancer in Japanese 査読有り

    Asahi Hishida, Keitaro Matsuo, Yasuyuki Goto, Mariko Naito, Kenji Wakai, Kazuo Tajima, Nobuyuki Hamajima

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   11 巻 ( 3 ) 頁: 669 - 673   2010年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ASIAN PACIFIC ORGANIZATION CANCER PREVENTION  

    Although many studies have shown that smoking is an established risk factor for gastric cancer, relatively few studies have investigated on which step smoking has effects in Helicobacter pylori (H. pylori) related gastric carcinogenesis. In this study we investigated the association of smoking with risk of three steps leading to gastric cancer: H. pylori infection, gastric atrophy, and gastric cancer. Among the participants who visited Aichi Cancer Center Hospital from year 2001 to 2005, 583 cases diagnosed as gastric cancer and age- and sex-frequency-matched 1,742 cancer free controls were sampled, from whom those without serum samples or without information about smoking habit were excluded, leaving 576 cases and 1,599 controls eligible for the analyses. Anti- H. pylori IgG antibody and serum pepsinogens (PG) were measured to detect H. pylori infection and gastric atrophy. Smoking status was asked by a self-administered questionnaire. The odds ratio (OR) of H. pylori infection, as well as the OR of gastric atrophy among the H. pylori seropositive controls was not significant for smokers. The age- and sex-adjusted OR of gastric cancer was significantly elevated relative to the subjects with gastric atrophy: OR=1.62 (95% confidence interval (CI), 1.19-2.22; P=0.002) for ever smokers and 2.52 (1.75-3.64; P &lt; 0.001) for current smokers, relative to never smokers. This study revealed that smoking behavior contributed to the increased risk of gastric carcinogenesis from gastric atrophy, and had little influence on H. pylori infection or gastric atrophy development.

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  198. Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese 査読有り

    Hishida A, Matsuo K, Goto Y, Mitsuda Y, Naito M, Wakai K, Tajima K, Hamajima N.

    J Gastroenterol   44 巻 ( 12 ) 頁: 1165-1171   2009年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00535-009-0118-7

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  199. Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population. 査読有り

    Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Ikebuchi Y, Ito K, Kusanagi Y, Chiba T, Tadokoro S, Takada Y, Oikawa Y, Inoue H, Suzuki K, Okada R, Nishiyama J, Domoto H, Watanabe S, Fujita M, Morimoto Y, Naito M, Nishio K, Hishida A, Wakai K, Asai Y, Niwa K, Kamakura K, Nonoyama S, Sakurai Y, Hosoya T, Kanai Y, Suzuki H, Hamajima N, Shinomiya N

    Science translational medicine   1 巻 ( 5 ) 頁: 5ra11   2009年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Science Translational Medicine  

    DOI: 10.1126/scitranslmed.3000237

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  200. Baseline data of Shizuoka area in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). 査読有り

    Asai Y, Naito M, Suzuki M, Tomoda A, Kuwabara M, Fukada Y, Okamoto A, Oishi S, Ikeda K, Nakamura T, Misu Y, Katase S, Tokumasu S, Nishio K, Ishida Y, Hishida A, Morita E, Kawai S, Okada R, Wakai K, Tamakoshi A, Hamajima N

    Nagoya journal of medical science   71 巻 ( 3-4 ) 頁: 137 - 144   2009年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18999/nagjms.71.3-4.137

    PubMed

  201. Associations of diabetes mellitus and BMI with the prostate-specific antigen concentration in Japanese men

    Mariko, NAITO, Asahi, HISHIDA, Kenji, WAKAI, Emi, MORITA, Sayo, KAWAI, Rieko, OKADA, Akiko, TAMAKOSHI, Nobuyuki, HAMAJIMA

    日本癌学会学術総会記事   68th 巻   頁: 343   2009年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  202. Smoking cessation, alcohol intake and transient increase in the risk of metabolic syndrome among Japanese smokers at one health checkup institution 査読有り

    Hishida A, Koyama A, Tomoda A, Katase S, Asai Y, Hamajima N.

    BMC Public Health   9 巻 ( 1 ) 頁: 263   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/1471-2458-9-263.

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  203. Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese. 査読有り

    Hishida A, Matsuo K, Goto Y, Naito M, Wakai K, Tajima K, Hamajima N

    BMC gastroenterology   9 巻 ( 1 ) 頁: 51   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC Gastroenterology  

    DOI: 10.1186/1471-230X-9-51

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  204. Toll-like receptor 4 +3725 G/C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese 査読有り

    Hishida A, Matsuo K, Goto Y, Mitsuda Y, Hiraki A, Naito M, Wakai K, Tajima K, Hamajima N.

    Helicobacter   14 巻 ( 1 ) 頁: 47-53   2009年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/j.1523-5378.2009.00659.x

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  205. RUNX3 polymorphisms, Helicobacter pylori seropositivity, and risk of gastric atrophy and cancer in Japanese 査読有り

    Hishida A, Matsuo K, Goto Y, Mitsuda Y, Naito M, Wakai K, Tajima K, Hamajima N

    J Gastroenterol   44 巻   頁: 1165-1171   2009年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  206. BASELINE DATA OF SHIZUOKA AREA IN THE JAPAN MULTI-INSTITUTIONAL COLLABORATIVE COHORT STUDY (J-MICC STUDY)

    Asai, Yatami, Naito, Mariko, Suzuki, Masumi, Tomoda, Akiko, Kuwabara, Mayumi, Fukada, Yuko, Okamoto, Ayumi, Oishi, Sachie, Ikeda, Kanako, Nakamura, Tsukino, Misu, Yasuko, Katase, Shiroh, Tokumasu, Satoshi, Nishio, Kazuko, Ishida, Yoshiko, Hishida, Asahi, Morita, Emi, Kawai, Sayo, Okada, Rieko, Wakai, Kenji, Tamakoshi, Akiko, Hamajima, Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   71 巻 ( 3-4 ) 頁: 137 - 144   2009年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

  207. Controls for monitoring the deterioration of stored blood samples in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). 査読有り

    Naito M, Eguchi H, Okada R, Ishida Y, Nishio K, Hishida A, Wakai K, Tamakoshi A, Hamajima N, J-MICC Study Group

    Nagoya journal of medical science   70 巻 ( 3-4 ) 頁: 107 - 115   2008年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18999/nagjms.70.3-4.107

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  208. 胃癌のリスクファクター, ハイリスクグループ 査読有り

    菱田朝陽, 浜島信之

    臨牀消化器内科   23 巻 ( 3 ) 頁: 351-355   2008年3月

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  209. BMI-1 is highly expressed in M0-subtype acute myeloid leukemia. 査読有り

    Sawa M, Yamamoto K, Yokozawa T, Kiyoi H, Hishida A, Kajiguchi T, Seto M, Kohno A, Kitamura K, Itoh Y, Asou N, Hamajima N, Emi N, Naoe T

    International journal of hematology   82 巻 ( 1 ) 頁: 42 - 7   2005年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:International Journal of Hematology  

    DOI: 10.1532/IJH97.05013

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  210. Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese. 査読有り

    Tanaka D, Hishida A, Matsuo K, Iwata H, Shinoda M, Yamamura Y, Kato T, Hatooka S, Mitsudomi T, Kagami Y, Ogura M, Tajima K, Suyama M, Naito M, Yamamoto K, Tamakoshi A, Hamajima N

    Nagoya journal of medical science   67 巻 ( 3-4 ) 頁: 117 - 124   2005年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18999/nagjms.67.3-4.117

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  211. HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses. 査読有り

    Millikan RC, Hummer AJ, Wolff MS, Hishida A, Begg CB

    Breast cancer research and treatment   89 巻 ( 3 ) 頁: 309 - 12   2005年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Breast Cancer Research and Treatment  

    DOI: 10.1007/s10549-004-2171-5

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  212. Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese. 査読有り

    Hishida A, Matsuo K, Tajima K, Ogura M, Kagami Y, Taji H, Morishima Y, Emi N, Naoe T, Hamajima N

    Leukemia & lymphoma   45 巻 ( 5 ) 頁: 957 - 64   2004年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/10428190310001638878

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  213. Polymorphism in the hMSH2 gene (gIVS 12-6T--&gt;C) and risk of non-Hodgkin lymphoma in a Japanese population. 査読有り

    Hishida A, Matsuo K, Hamajima N, Ito H, Ogura M, Kagami Y, Taji H, Morishima Y, Emi N, Tajima K

    Cancer genetics and cytogenetics   147 巻 ( 1 ) 頁: 71 - 4   2003年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Cancer Genetics and Cytogenetics  

    DOI: 10.1016/s0165-4608(03)00185-7

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  214. Trisomy X in Philadelphia chromosome-negative cells during the course of Philadelphia chromosome-positive chronic myelocytic leukemia 査読有り

    Hishida A, Yamamoto K, Matsushita T, Tanimoto M, Saito H, Emi N.

    Cancer Genet Cytogenet   142 巻 ( 1 ) 頁: 83-85   2003年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  215. Recovery of normal hematopoiesis after severe bone marrow aplasia induced by interferon-alpha in a patient with chronic myelogenous leukemia 査読有り

    Hishida A, Yamamoto K, Kato C, Yokozawa T, Emi N, Tanimoto M, Saito H.

    Int J Hematol   77 巻 ( 1 ) 頁: 55-59   2003年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  216. Transforming growth factor B1 T29C polymorphism and breast cancer risk in Japanese women 査読有り

    Hishida A, Iwata H, Hamajima N, Matsuo K, Mizutani M, Iwase T, Miura S, Emi N, Hirose K, Tajima K.

    Breast Cancer   10 巻 ( 1 ) 頁: 63-69   2003年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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▼全件表示

MISC 16

  1. 血清尿酸値の大規模ゲノムワイドメタ解析により23個の新規尿酸関連遺伝子座を同定した

    中杤昌弘, 金井仁弘, 中山昌喜, 菱田朝陽, 河村優輔, 池崎裕昭, 島ノ江千里, 嶽崎俊郎, 尾崎悦子, 鈴木貞夫, 喜多義邦, 栗木清典, 有澤幸吉, 松尾恵太郎, 三上春夫, 四ノ宮成祥, 横田充弘, 若井建志, 岡田随象, 岡田随象, 松尾洋孝  

    日本疫学会学術総会講演集(Web)30th 巻   2020年

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  2. 飲料品の摂取量と腎機能低下との関連 J-MICC Study大幸地区

    藤井 亮輔, 近藤 高明, 菱田 朝陽, 大西 丈二, 内藤 真理子, 浜島 信之, 若井 建志  

    日本公衆衛生学会総会抄録集78回 巻   頁: 219 - 219   2019年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

  3. 血清尿酸値の変化率と慢性腎臓病の新規発症 J-MICC Study大幸地区

    藤井 亮輔, 近藤 高明, 菱田 朝陽, 大西 丈二, 内藤 真理子, 浜島 信之, 若井 建志  

    日本公衆衛生学会総会抄録集77回 巻   頁: 347 - 347   2018年10月

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    記述言語:日本語   出版者・発行元:日本公衆衛生学会  

  4. GWASとSNP-set Kernel Association Tests(SKAT)により見出されたPSCA遺伝子とピロリ菌関連胃粘膜萎縮の関連(The association of PSCA gene and H. pylori-related gastric atrophy risk detected by GWAS and SKAT)

    菱田 朝陽, 藤井 亮輔, 中杤 昌弘, 川合 紗世, 伊藤 秀美, 松尾 恵太郎, 渡邉 美貴, 鈴木 貞夫, 栗山 長門, 内藤 真理子, 若井 建志  

    日本癌学会総会記事77回 巻   頁: 1242 - 1242   2018年9月

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    記述言語:英語   出版者・発行元:日本癌学会  

  5. Genome-wide association study of renal function traits with 1000 Genomes-based imputation in a large population-based Japanese cohort - data from the J-MICC Study 査読有り

    Asahi Hishida, Masahiro Nakatochi, Masato Akiyama, Yoichiro Kamatani, Takeshi Nishiyama, Hidemi Ito, Isao Oze, Yuichiro Nishida, Megumi Hara, Naoyuki Takashima, Tanvir Chowdhury Turin, Miki Watanabe, Sadao Suzuki, Rie Ibusuki, Ippei Shimoshikiryo, Yohko Nakamura, Haruo Mikami, Hiroaki Ikezaki, Norihiro Furusho, Kiyonori Kuriki, Kaori Endoh, Teruhide Koyama, Daisuke Matsui, Hirokazu Uemura, Kokichi Arisawa, Tae Sasakabe, Rieko Okada, Sayo Kawai, Mariko Naito, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai, The Japan Multi-Institutional Collaborative Cohort, J-MICC, Study Group  

    American Journal of Nephrology47 巻 ( 5 ) 頁: 304-316   2018年5月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1159/000488946

  6. The association between the TLR2 gene and risk of H. pylori-related gastric atrophy detected by SKAT

    Hishida Asahi, Fujii Ryosuke, Nakatochi Masahiro, Kawai Sayo, Oze Isao, Matsuo Keitaro, Tamai Yuya, Suzuki Sadao, Kuriyama Nagato, Watanabe Yoshiyuki, Naito Mariko, Wakai Kenji  

    CANCER SCIENCE109 巻   頁: 767 - 767   2018年1月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY  

    Web of Science

  7. SNP-set Kernel Association Tests(SKAT)により見出されたTLR2遺伝子とピロリ菌関連胃粘膜萎縮の関連

    菱田 朝陽, 藤井 亮輔, 中杤 昌弘, 川合 紗世, 尾瀬 功, 松尾 恵太郎, 玉井 裕也, 鈴木 貞夫, 栗山 長門, 渡邊 能行, 内藤 真理子, 若井 建志  

    日本癌学会総会記事76回 巻   頁: P - 2389   2017年9月

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    記述言語:英語   出版者・発行元:日本癌学会  

  8. EPA-ENRICHED NUTRITION AS A COMBINED MODALITY THERAPY FOR CACHECTIC CANCER PATIENTS UNDERGOING SYSTEMIC CHEMOTHERAPY IN GASTROINTESTINAL CANCER

    Yoshinaga Okugawa, Yuji Toiyama, Yumiko Shirai, Asahi Hishida, Hiroyuki Fujikawa, Hiromi Yasuda, Shigeyuki Yoshiyama, Masaki Ohi, Toshimitsu Araki, Koji Tanaka, Yasuhiro Inoue, Motoyoshi Tanaka, Yasuhiko Mohri, Ajay Goel, Masato Kusunoki, Chikao Miki  

    GASTROENTEROLOGY152 巻 ( 5 ) 頁: S416 - S416   2017年4月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:W B SAUNDERS CO-ELSEVIER INC  

    Web of Science

  9. Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies 査読有り

    Hattori Y, Naito M, Satoh M, Nakatochi M, Naito H, Kato M, Takagi S, Matsunaga T, Seiki T, Sasakabe T, Suma S, Kawai S, Okada R, Hishida A, Hamajima N, Wakai K  

    Toxicol Sci152 巻 ( 1 ) 頁: 181-193   2016年7月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1093/toxsci/kfw080

    PubMed

  10. Significant Associations of Abdominal Obesity with LYPLAL1 Polymorphism (rs4846567) among a General Japanese Population: A Cross-Sectional Study.

    T. Tamura, E. Morita, S. Kawai, T. Sasakabe, N. Fukuda, Y. Sugimoto, S. Suma, J. Mokuno, H. Nakagawa, A. Hishida, R. Okada, M. Naito, N. Hamajima, K. Wakai  

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY44 巻   頁: 243 - 244   2015年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS  

    Web of Science

  11. 健康な日本人成人の血清GGT値とGGT1intron1A/G遺伝子多型の関連

    川合紗世, 内藤真理子, 森田えみ, 岡田理恵子, 菱田朝陽, 若井建志, 浜島信之  

    人間ドック28 巻 ( 2 ) 頁: 296   2013年7月

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    記述言語:日本語  

    J-GLOBAL

  12. 痛風病因遺伝子ABCG2の変異が血清尿酸値におよぼす影響

    中山昌喜, 松尾洋孝, 高田雄三, 中島宏, 佐藤弘樹, 中村好宏, 森厚嘉, 内藤真理子, 菱田朝陽, 若井建志, 清水聖子, 及川雄二, 丹羽和紀, 櫻井裕, 市田公美, 浜島信之, 四ノ宮成祥  

    Journal of Epidemiology23 巻 ( Supplement 1 ) 頁: 152   2013年1月

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    記述言語:日本語  

    J-GLOBAL

  13. Toll-Like Receptor 4 +3725 G/C Polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese (vol 14, pg 47, 2009)

    Asahi Hishida, Keitaro Matsuo, Yasuyuki Goto, Yoko Mitsuda, Akio Hiraki, Mariko Naito, Kenji Wakai, Kazuo Tajima, Nobuyuki Hamajima  

    HELICOBACTER14 巻 ( 5 ) 頁: 151 - 152   2009年10月

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    記述言語:英語   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

    Web of Science

  14. ELISA法を用いたIL‐1B C‐31T,IL‐1RN VNTR遺伝子多型と血中IL‐1β,IL‐6レベルとの関連についての検討

    菱田朝陽, 江口英孝, 西尾和子, 石田喜子, 川合沙世, 岡田理恵子, 内藤真理子, 若井建志, 浜島信之  

    J Epidemiol18 巻 ( 1 Supplement ) 頁: 199   2008年1月

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    記述言語:日本語  

    J-GLOBAL

  15. フィラデルフィア染色体陽性急性リンパ白血病に対するSTI-571を含む化学療法に対する反応性診断

    前佛 均, 三好 規之, 片桐 豊雅, 柳田 正光, 菱田 朝陽, 直江 知樹, 竹内 仁, 角田 達彦, 大野 竜三, 中村 祐輔  

    日本癌学会総会記事65回 巻   頁: 53 - 53   2006年9月

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    記述言語:日本語   出版者・発行元:日本癌学会  

  16. BMI-1 overexpression in 32Dcl3 cells suppresses granulocytic differentiation and ameliorates their growth under IL-3 diminished conditions.

    A Hishida, K Yamamoto, M Sawa, T Naoe  

    BLOOD106 巻 ( 11 ) 頁: 133B - 133B   2005年11月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER SOC HEMATOLOGY  

    Web of Science

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科研費 6

  1. がん化学療法時における栄養摂取量についてのゲノム情報を加味したエビデンスの確立

    研究課題/研究課題番号:25460745  2013年4月 - 2017年3月

    科学研究費助成事業  基盤研究(C)

    菱田 朝陽, 浜島 信之, 三木 誓雄

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    担当区分:研究代表者 

    配分額:5070000円 ( 直接経費:3900000円 、 間接経費:1170000円 )

    今回の研究で同意の得られた59例の消化器がん患者について、各種遺伝子型と生命予後、体重減少との関連について解析を行った。結果、IL-1RN VNTRの2-repeat alleleをもつ人、IL-6 -634 G/G遺伝子型を持つ人、IL-10 -1082 A/G遺伝子型を持つ人、のそれぞれにおいて、調整ハザード比が9.20, 41.01, 6.49と、有意に生命予後が悪くなることが観察された。また、体重減少についての解析では、AKT1 rs1130233遺伝子多型のAアレルを持つ人において、半年以内に5%以上の体重減少を起こすリスクの調整オッズ比が4.57と、有意なリスクの上昇が観察された。

  2. ピロリ菌と胃粘膜萎縮発生における遺伝子環境交互作用に関する研究

    研究課題/研究課題番号:20790422  2008年 - 2009年

    科学研究費助成事業  若手研究(B)

    菱田 朝陽

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    担当区分:研究代表者 

    配分額:3900000円 ( 直接経費:3000000円 、 間接経費:900000円 )

    本研究において、日本人の胃粘膜萎縮発生におけるPTPN11イントロン3 G/A 遺伝子多型の重要性を再確認し、TLR4の新多型、TLR4+3725G/C遺伝子多型と重度胃粘膜萎縮の関連を明らかにし、また、胃粘膜上皮の分化に関与する遺伝子、RUNX3の遺伝子多型が胃粘膜萎縮発生に関与することを世界に先駆けて明らかにした。本研究により、日本人の胃粘膜萎縮予防に有用な情報を提供できたと考えている。

  3. コホート保存検体RNA解析による消化器癌・肺癌早期診断マーカーに関する研究

    研究課題/研究課題番号:19K10598  2019年4月 - 2022年3月

    菱田 朝陽

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    担当区分:研究代表者 

    配分額:4420000円 ( 直接経費:3400000円 、 間接経費:1020000円 )

    本研究では、病院受診消化器癌・肺癌患者と健常人対照における末梢血RNAの発現データ解析を行い、消化器癌・肺癌診断マーカーとしてのRNA発現データの有用性を検討するとともに、大規模ゲノムコホート研究である日本多施設コーホート研究(J-MICC Study)の凍結保存検体(血液・尿)を用いてその有効性を確認し、我が国における大規模ゲノムコホートデータとその凍結保存検体を用いた、RNA発現解析によるがん早期診断マーカー研究の活性化と、血液・尿のRNA発現情報を用いた、消化器癌・肺癌の臨床診断前の超早期診断法の有用性の検証と健診等の臨床現場における実用化を目指す。
    2019年度は、研究の準備段階として、解析対象の消化器がん既存検体の確認(伊賀市立上野総合市民病院外科からの消化器がん70例(食道癌4例、胃癌12例、大腸・直腸癌43例、膵臓癌5例、胆管癌2例)と、実験手技(microRNA(miRNA)を中心とするRNAの抽出・精製手技)・実験環境の確認(藤田医科大学医学部衛生学(研究分担者:山田宏哉講師)、名古屋大学大幸キャンパス)、各共同施設(名古屋大学大学院医学系研究科予防医学、三重大学大学院医学系研究科消化管・小児外科学(研究分担者:奥川喜永講師、問山裕二准教授)、伊賀市立上野総合市民病院(研究分担者:田中光司院長・三重大学客員准教授))における倫理審査委員会の申請手続きを進めた。特に、倫理審査委員会の申請手続きについては、各共同施設間の調整に時間を要し、また、近年のマイクロRNA研究の進展により、確認のためのシークエンス解析が追加で必要とされる傾向にあるため、同解析のための倫理審査委員会への修正申請を改めて行うなど、当初の予定より準備に時間を要した。そのため、当初予定されていた、既存検体(伊賀市立上野総合市民病院外科において収集した70例の消化器がん(食道癌・胃癌・大腸・直腸癌・膵臓癌・胆管癌)検体と、伊賀市コホート研究における非がん症例検体)のmiRNAを中心とするRNAの抽出・測定作業、および、発現データの統計解析による、消化器癌早期診断に有用なmiRNAの探索的解析については、次年度以降へ持ち越しとなった。
    倫理審査委員会の申請手続きにおいて、各共同施設間の調整に時間を要し、また、近年のマイクロRNA研究の進展により、確認のためのシークエンス解析が追加で必要とされる傾向にあるため、同解析のための倫理審査委員会への修正申請を改めて行うなど、当初の予定より準備に時間を要したため。
    今年度は、倫理審査委員会の承認手続きと実験体制の準備が整ったため、検体からのmicroRNA(miRNA)を中心としたRNA抽出と、miRNAアレイによる発現量測定と、得られた発現量データの統計解析を、第一段階の探索フェーズ(Discovery Phase)を中心に行い、消化器癌の早期発見に有用な、miRNAのセットの発掘を行う予定である。

  4. ピロリ菌関連胃癌・萎縮性胃炎におけるSNP-setによる遺伝要因探索と再現性検証

    研究課題/研究課題番号:16K09032  2016年4月 - 2020年3月

    菱田 朝陽

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    担当区分:研究代表者 

    配分額:4810000円 ( 直接経費:3700000円 、 間接経費:1110000円 )

    今回、血清抗ピロリ菌抗体・ペプシノゲン(PG)値の測定値を有する、日本多施設コーホート研究(J-MICC Study)、愛知県がんセンター病院症例対照研究(HERPACC2)の参加者検体、各3,385例と2,885例を用いて、萎縮性胃炎(PG1 <= 70ng/ml & PG1/PG2 <= 3)、重症萎縮性胃炎(PG1 <= 30ng/ml & PG1/PG2 <= 2)の有無、および、PG1/PG2比とのゲノムワイド関連解析(GWAS)を行い、ピロリ菌関連胃がん発症リスクに関わる8q24.3領域のPSCA遺伝子のSNPsがGWAS有意となり、SNP-set解析でも同遺伝子が有意であった。
    今回の研究で、日本人に多いピロリ菌関連胃がんの前がん病変である、ピロリ菌関連萎縮性胃炎の遺伝的要因が、全ゲノムレベルでPSCA遺伝子にあることが明らかになり、将来の遺伝的体質に基づくピロリ菌関連胃がん及び萎縮性胃炎の個別化予防のための有用な情報(具体的には、事前に疾患リスクを知ることによる、ピロリ菌除菌や、胃がん検診受診などの行動へのきっかけ作り、等)を提供できたものと考えている。

  5. がん化学療法時における栄養摂取量についてのゲノム情報を加味したエビデンスの確立

    2013年4月 - 2016年3月

    科学研究費補助金  基盤研究(B)

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    担当区分:研究代表者 

  6. ピロリ菌と胃粘膜萎縮発生における遺伝子環境交互作用に関する研究

    2008年

    科学研究費補助金  若手研究(B),課題番号:20790422

    菱田 朝陽

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    担当区分:研究代表者 

▼全件表示

 

学術貢献活動 2

  1. Editorial Board Member, BMC Medical Genetics

    役割:審査・評価, 査読

    2018年1月 - 2020年12月

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    種別:審査・学術的助言 

  2. Editorial Board Member, World Journal of Gastrointestinal Oncology

    役割:審査・評価, 査読

    2016年1月 - 2018年12月

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    種別:査読等