Updated on 2022/03/30

写真a

 
HISHIDA, Asahi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Social Life Science Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor

Degree 3

  1. M.P.H. ( 2012.5 ) 

  2. Ph.D. ( 2005.3   Nagoya University ) 

  3. M.D. ( 1998.3   Nagoya University ) 

Research Interests 2

  1. Gene-Environment Interaction

  2. Cancer Molecular Epidemiology

Research Areas 2

  1. Life Science / Medical management and medical sociology

  2. Life Science / Medical management and medical sociology

Current Research Project and SDGs 1

  1. Cancer Molecular Epidemiology

Research History 1

  1. Nagoya University   Graduate School of Medicine Program in Integrated Medicine Social Life Science   Associate professor

    2020.1

Education 3

  1. University of North Carolina at Chapel Hill   Department of Epidemiology

    - 2012.5

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    Country: United States

  2. Nagoya University   Graduate School, Division of Medical Sciences

    - 2005.3

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    Country: Japan

  3. Nagoya University   Faculty of Medicine

    - 1998.3

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    Country: Japan

 

Papers 196

  1. A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern.

    Suzuki H, Nakamura Y, Matsuo K, Imaeda N, Goto C, Narita A, Shimizu A, Takashima N, Matsui K, Miura K, Nakatochi M, Hishida A, Tamura T, Kadomatsu Y, Okada R, Nishida Y, Shimanoe C, Nishimoto D, Takezaki T, Oze I, Ito H, Ikezaki H, Murata M, Matsui D, Ozaki E, Mikami H, Nakamura Y, Suzuki S, Watanabe M, Arisawa K, Uemura H, Kuriki K, Momozawa Y, Kubo M, Kita Y, Takeuchi K, Wakai K

    European journal of clinical nutrition   Vol. 75 ( 6 ) page: 937 - 945   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:European Journal of Clinical Nutrition  

    DOI: 10.1038/s41430-020-00823-z

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  2. An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate.

    Nakatochi M, Toyoda Y, Kanai M, Nakayama A, Kawamura Y, Hishida A, Mikami H, Matsuo K, Takezaki T, Momozawa Y, Biobank Japan Project., Kamatani Y, Ichihara S, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H, Japan Uric Acid Genomics Consortium (Japan Urate).

    Rheumatology (Oxford, England)     2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/rheumatology/keab404

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  3. Association of self-reported moderate vegetable juice intake with small decline in kidney function in a five-year prospective study.

    Fujii R, Kondo T, Tsukamoto M, Kawai S, Sasakabe T, Naito M, Kubo Y, Okada R, Tamura T, Hishida A, Ueyama J, Hayashi Y, Ohnishi J, Hamajima N, Takeuchi K, Wakai K

    Nutrition (Burbank, Los Angeles County, Calif.)   Vol. 84   page: 111114   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nutrition  

    DOI: 10.1016/j.nut.2020.111114

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  4. Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.

    Kawaguchi M, Nakayama A, Aoyagi Y, Nakamura T, Shimizu S, Kawamura Y, Takao M, Tamura T, Hishida A, Nagayoshi M, Nagase M, Ooyama K, Ooyama H, Shinomiya N, Matsuo H

    Human cell   Vol. 34 ( 2 ) page: 293 - 299   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Human Cell  

    DOI: 10.1007/s13577-021-00485-4

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  5. A genome-wide association study on fish consumption in a Japanese population—the Japan Multi-Institutional Collaborative Cohort study

    Suzuki T.

    European Journal of Clinical Nutrition   Vol. 75 ( 3 ) page: 480 - 488   2021.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:European Journal of Clinical Nutrition  

    DOI: 10.1038/s41430-020-00702-7

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  6. Assessing the relationship between high-sensitivity C-reactive protein and kidney function employing mendelian randomization in a Japanese community based J-MICC Study.

    Fujii R, Hishida A, Nishiyama T, Nakatochi M, Matsuo K, Ito H, Nishida Y, Shimanoe C, Nakamura Y, Turin TC, Suzuki S, Watanabe M, Ibusuki R, Takezaki T, Mikami H, Nakamura Y, Ikezaki H, Murata M, Kuriki K, Kuriyama N, Matsui D, Arisawa K, Katsuura-Kamano S, Tsukamoto M, Tamura T, Kubo Y, Kondo T, Momozawa Y, Kubo M, Takeuchi K, Wakai K

    Journal of epidemiology     2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20200540

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  7. Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study.

    Hishida A, Nakatochi M, Tamura T, Nagayoshi M, Okada R, Kubo Y, Tsukamoto M, Kadomatsu Y, Suzuki S, Nishiyama T, Kuriyama N, Watanabe I, Takezaki T, Nishimoto D, Kuriki K, Arisawa K, Katsuura-Kamano S, Mikami H, Kusakabe M, Oze I, Koyanagi YN, Nakamura Y, Kadota A, Shimanoe C, Tanaka K, Ikezaki H, Murata M, Kubo M, Momozawa Y, Takeuchi K, Wakai K, for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group.

    Nagoya journal of medical science   Vol. 83 ( 1 ) page: 183 - 194   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nagoya Journal of Medical Science  

    DOI: 10.18999/nagjms.83.1.183

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  8. Green tea consumption and the risk of colorectal cancers in Japanese - data from the JACC Study

    Hishida Asahi, Wakai Kenji, Tamakoshi Akiko

    CANCER SCIENCE   Vol. 112   page: 586 - 586   2021.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

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  9. Cost-Effectiveness of Behavior Modification Intervention for Patients With Chronic Kidney Disease in the FROM-J Study

    Okubo R.

    Journal of Renal Nutrition     2021

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Journal of Renal Nutrition  

    DOI: 10.1053/j.jrn.2020.12.008

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  10. Associations between peroxisome proliferator-activated receptor γ (PPAR-γ) polymorphisms and serum lipids: Two cross-sectional studies of community-dwelling adults.

    Matsunaga T, Naito M, Yin G, Hishida A, Okada R, Kawai S, Sasakabe T, Kadomatsu Y, Tsukamoto M, Kubo Y, Tamura T, Takeuchi K, Mori A, Hamajima N, Wakai K

    Gene   Vol. 762   page: 145019   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Gene  

    DOI: 10.1016/j.gene.2020.145019

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  11. Association between alcohol intake pattern and metabolic syndrome components and simulated change by alcohol intake reduction: A cross-sectional study from the Japan Multi-Institutional Collaborative Cohort Study.

    Shimoshikiryo I, Ibusuki R, Shimatani K, Nishimoto D, Takezaki T, Nishida Y, Shimanoe C, Hishida A, Tamura T, Okada R, Kubo Y, Ozaki E, Matsui D, Suzuki S, Nakagawa-Senda H, Kuriki K, Kita Y, Takashima N, Arisawa K, Uemura H, Ikezaki H, Furusyo N, Oze I, Koyanagi YN, Mikami H, Nakamura Y, Naito M, Wakai K, J-MICC Study Group.

    Alcohol (Fayetteville, N.Y.)   Vol. 89   page: 129 - 138   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Alcohol  

    DOI: 10.1016/j.alcohol.2020.09.002

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  12. Association between plasma levels of homocysteine, folate, and vitamin B<sub>12</sub>, and dietary folate intake and hypertension in a cross-sectional study.

    Tamura T, Kuriyama N, Koyama T, Ozaki E, Matsui D, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Hishida A, Sasakabe T, Kawai S, Naito M, Takashima N, Kadota A, Tanaka K, Hara M, Suzuki S, Nakagawa-Senda H, Takezaki T, Shimoshikiryo I, Ikezaki H, Murata M, Oze I, Ito H, Mikami H, Nakamura Y, Kuriki K, Arisawa K, Uemura H, Takeuchi K, Wakai K

    Scientific reports   Vol. 10 ( 1 ) page: 18499   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Scientific Reports  

    DOI: 10.1038/s41598-020-75267-3

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  13. A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population.

    Akashi A, Nakayama A, Kamatani Y, Higashino T, Shimizu S, Kawamura Y, Imoto M, Naito M, Hishida A, Kawaguchi M, Takao M, Matsuo M, Takada T, Ichida K, Ooyama H, Shinomiya N, Matsuo H

    Human cell   Vol. 33 ( 2 ) page: 303 - 307   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Human Cell  

    DOI: 10.1007/s13577-019-00318-5

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  14. Frequency of forest walking is not associated with prevalence of hypertension based on cross-sectional studies of a general Japanese population: a reconfirmation by the J-MICC Daiko Study.

    Morita E, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Sasakabe T, Kawai S, Hishida A, Naito M, Wakai K

    Nagoya journal of medical science   Vol. 81 ( 3 ) page: 489 - 500   2019.8

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    DOI: 10.18999/nagjms.81.3.489

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  15. Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study

    Iimuro Satoshi, Kaneko Tetsuji, Ohashi Yasuo, Watanabe Tsuyoshi, Nitta Kosaku, Akizawa Tadao, Matsuo Seiichi, Imai Enyu, Makino Hirofumi, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 23 ( 7 ) page: 956 - 968   2019.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Clinical and Experimental Nephrology  

    DOI: 10.1007/s10157-019-01730-9

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  16. Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population.

    Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, Shimizu A, Wang C, Tanaka H, Watanabe M, Hosono A, Tamai Y, Yamada T, Yamaji T, Sawada N, Fukumoto K, Otsuka K, Tanno K, Tomita H, Kojima K, Nagasaki M, Hozawa A, Hishida A, Sasakabe T, Nishida Y, Hara M, Ito H, Oze I, Nakamura Y, Mikami H, Ibusuki R, Takezaki T, Koyama T, Kuriyama N, Endoh K, Kuriki K, Turin TC, Naoyuki T, Katsuura-Kamano S, Uemura H, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Sasaki M, Yamamoto M, Tsugane S, Wakai K, Suzuki S

    Sleep   Vol. 42 ( 6 )   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Sleep  

    DOI: 10.1093/sleep/zsz046

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  17. GENOME-WIDE META-ANALYSIS REVEALED MULTIPLE NOVEL LOCI ASSOCIATED WITH SERUM URIC ACIDLEVELS IN JAPANESE

    Matsuo Hirotaka, Nakatochi Masahiro, Kanai Masahiro, Nakayama Akiyoshi, Hishida Asahi, Kawamura Yusuke, Nakajima Mayuko, Kamatani Yoichiro, Shinomiya Nariyoshi, Yokota Mitsuhiro, Wakai Kenji, Okada Yukinori

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 78   page: 95 - 95   2019.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/annrheumdis-2019-eular.4039

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  18. Dysphagia after C2-7 in situ Posterior Fusion in a Patient with Diffuse Idiopathic Skeletal Hyperostosis: Case Report of a Rare Presentation

    Ito Kenyu, Kadono Izumi, Okada Takashi, Hishida Aika, Ando Kei, Kobayashi Kazuyoshi, Tsushima Mikito, Machino Masaaki, Ota Kyotaro, Morozumi Masayoshi, Tanaka Satoshi, Nishida Yoshihiro, Ishiguro Naoki, Imagama Shiro

    SPINE SURGERY AND RELATED RESEARCH   Vol. 3 ( 3 ) page: 270 - 273   2019

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Spine Surgery and Related Research  

    DOI: 10.22603/ssrr.2018-0083

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  19. Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population

    Ryosuke Fujii, Asahi Hishida, Michael C. Wu, Takaaki Kondo, Yuta Hattori, Mariko Naito, Kaori Endoh, Masahiro Nakatochi, Nobuyuki Hamajima, Michiaki Kubo, Kiyonori Kuriki, Kenji Wakai

    Nagoya Journal of Medical Science   Vol. 80 ( 1 ) page: 109 - 120   2018.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Nagoya University  

    The number of pollinosis patients in Japan has significantly increased over the past 20 years. The majority of genome-wide association studies (GWAS) on pollinosis have been conducted in subjects of European descent, with few studies in Japanese populations. The aim of our GWAS was to identify genetic loci associated with self-reported pollinosis in a Japanese population and to understand its molecular background using a combination of single nucleotide polymorphisms (SNPs) and gene- and pathway-based analyses. A total of 731 and 560 individuals who were recruited as participants of the Japan Multi-Institutional Collaborative Cohort Study participated in the discovery and replication phases, respectively. The phenotype of pollinosis was based on the information from a self-administered questionnaire. In the single-SNP analysis, four SNPs (rs11975199, rs11979076, rs11979422, and rs12669708) reached suggestive significance level (P &lt
    1 × 10-4) and had effects in the same direction in both phases of the study. The pathway-based analysis identified two suggestive pathways (nucleotide-binding oligomerization domain -like receptor and tumor necrosis factor signaling pathways). Both rs1143633 and rs3917368 in the interleukin-1B gene showed associations in the retrace (from pathway to gene and SNP) analysis. We performed single-SNP, gene, and pathway analysis and shed light on the molecular mechanisms underlying pollinosis in a Japanese population.

    DOI: 10.18999/nagjms.80.1.109

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  20. Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study

    Asahi Hishida, Masahiro Nakatochi, Masato Akiyama, Yoichiro Kamatani, Takeshi Nishiyama, Hidemi Ito, Isao Oze, Yuichiro Nishida, Megumi Hara, Naoyuki Takashima, Tanvir Chowdhury Turin, Miki Watanabe, Sadao Suzuki, Rie Ibusuki, Ippei Shimoshikiryo, Yohko Nakamura, Haruo Mikami, Hiroaki Ikezaki, Norihiro Furusyo, Kiyonori Kuriki, Kaori Endoh, Teruhide Koyama, Daisuke Matsui, Hirokazu Uemura, Kokichi Arisawa, Tae Sasakabe, Rieko Okada, Sayo Kawai, Mariko Naito, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai

    American Journal of Nephrology   Vol. 47 ( 5 ) page: 304 - 316   2018

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    Background: Chronic kidney disease (CKD) is a rapidly growing, worldwide public health problem. Recent advances in genome-wide-association studies (GWAS) revealed several genetic loci associated with renal function traits worldwide. Methods: We investigated the association of genetic factors with the levels of serum creatinine (SCr) and the estimated glomerular filtration rate (eGFR) in Japanese population-based cohorts analyzing the GWAS imputed data with 11,221 subjects and 12,617,569 variants, and replicated the findings with the 148,829 hospital-based Japanese subjects. Results: In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the LDL receptor related protein 2 gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the BCAS3 gene locus, and chr 18 with 3 variants including rs74183647 in the nuclear factor of -activated T-cells 1 gene locus) reached the suggestive level of p &lt
    1 × 10-6 in association with eGFR and SCr, and 2 variants on chr 4 (including rs78351985 in the microsomal triglyceride transfer protein gene locus) fulfilled the suggestive level in association with the risk of CKD. In the replication phase, 25 variants within 3 loci (chr 2 with 7 variants, chr 17 with 15 variants and chr 18 with 3 variants) in association with eGFR and SCr, and 2 variants on chr 4 associated with the risk of CKD became nominally statistically significant after Bonferroni correction, among which 15 variants on chr 17 and 3 variants on chr 18 reached genome-wide significance of p &lt
    5 × 10-8 in the combined study meta-analysis. The associations of the loci on chr 2 and 18 with eGFR and SCr as well as that on chr 4 with CKD risk have not been previously reported in the Japanese and East Asian populations. Conclusion: Although the present GWAS of renal function traits included the largest sample of Japanese participants to date, we did not identify novel loci for renal traits. However, we identified the novel associations of the genetic loci on chr 2, 4, and 18 with renal function traits in the Japanese population, suggesting these are transethnic loci. Further investigations of these associations are expected to further validate our findings for the potential establishment of personalized prevention of renal disease in the Japanese and East Asian populations.

    DOI: 10.1159/000488946

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  21. Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change.

    Higashibata T, Wakai K, Naito M, Morita E, Hishida A, Hamajima N, Hara M, Suzuki S, Hosono S, Takashima N, Ohnaka K, Takada A, Mikami H, Watanabe Y, Uemura H, Kubo M, Tanaka H

    Gene   Vol. 594 ( 1 ) page: 16 - 22   2016.12

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    SIRT1 acts as a cellular sensor to detect energy availability and modulates fat and glucose metabolism. This study assessed the effects of self-reported calorie restriction (CR) and exercise on correlations between SIRT1 polymorphisms and body mass index (BMI) and long-term weight change. This cross-sectional study enrolled 4023 subjects aged 35-69years (1847 men and 2176 women) selected from participants in the Japan Multi-Institutional Collaborative Cohort Study. This study was based on a self-administered questionnaire. No significant correlations between SIRT1 polymorphisms and BMI or long-term weight change were found in either the CR or the active groups. In the no-CR group, women with the rs1467568 G allele had a higher BMI than women without (p=0.02). Moreover, women with the rs7895833 A or rs1467568 G allele gained more weight from the age of 20years than women without these alleles (p=0.03 for rs7895833 and p=0.003 for rs1467568). In addition, the odds ratios (95% confidence intervals) of these alleles for overweight (BMI &gt;27.5kg/m(2)) were significantly high in the no-CR women group (1.78 (1.06-2.99) for rs7895833 and 1.88 (1.13-3.15) for rs1467568) but not in the CR group. The results of this study suggest that CR might override the genetic contributions of the SIRT1 rs7895833 A and rs1467568 G alleles to BMI and long-term weight change.

    DOI: 10.1016/j.gene.2016.08.051

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  22. Metallothionein MT2A A-5G Polymorphism and the Risk for Chronic Kidney Disease and Diabetes

    Hattori Yuta, Naito Mariko, Satoh Masahiko, Nakatochi Masahiro, Naito Hisao, Kato Masashi, Takagi Sahoko, Matsunaga Takashi, Seiki Toshio, Sasakabe Tae, Suma Shino, Kawai Sayo, Okada Rieko, Hishida Asahi, Hamajima Nobuyuki, Wakai Kenji

    TOXICOLOGICAL SCIENCES   Vol. 154 ( 2 ) page: 198 - 199   2016.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/toxsci/kfw204

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  23. A variant of the CLOCK gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population.

    Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Kokichi Arisawa, Nobuyuki Hamajima, Asahi Hishida, Sayo Kawai, Isao Oze, Koichi Shinchi, Naoyuki Takashima, Sadao Suzuki, Noriko Nakahata, Haruo Mikami, Keizo Ohnaka, Nagato Kuriyama, Michiaki Kubo, Hideo Tanaka

    Journal of Diabetes   Vol. 8 ( 5 ) page: 667 - 676   2016.9

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    Circadian rhythm disruption is recognized as the cause of various health disorders. This study evaluated associations between single nucleotide polymorphisms in the core circadian gene, CLOCK, and prevalent type 2 diabetes in the Japanese population. We analyzed cross-sectional data from 2,485 subjects (1,243 men and 1,242 women; age, 35-69 years) who were enrolled in the baseline surveys of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Associations between 3 CLOCK gene polymorphisms (rs1801260, rs3736544, and rs4864548) and prevalent obesity (BMI ?25 kg/m(2) ), overweight (BMI ?23 kg/m(2) ), and diabetes were evaluated by logistic regression analyses; haplotype analysis and stratified analyses for prevalent diabetes were also conducted. Compared to those who were homozygous for the respective major alleles, subjects with the rs1801260 minor allele C showed a significantly higher odds ratio (95% CI) of 1.5 (1.1-2.1) for prevalent diabetes, after adjustment for potential confounding factors, including BMI. When stratified by overweight, the associations between rs1801260 and prevalent diabetes were marked and significant in non-overweight subjects but were not significant in overweight subjects. The TGA (rs1801260 - rs3736544 - rs4864548) haplotype was associated with lower prevalence of diabetes, and the CGG haplotype was associated with higher prevalence of diabetes. CLOCK gene variants and related haplotypes are associated with prevalent type 2 diabetes in the Japanese population in whom obesity is less common, and the association between a CLOCK gene variants at rs1801260 and prevalent diabetes is enhanced in normal-build subjects.

    DOI: 10.1111/1753-0407.12344

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  24. SERUM URIC ACID IS ASSOCIATED WITH WITHIN-VISIT BLOOD PRESSURE VARIABILITY AMONG WOMEN; THE RESULTS OF A FIVE YEAR SURVEY FROM THE J-MICC DAIKO STUDY

    Okada Rieko, Naito Mariko, Morita Emi, Takagi Sahoko, Matsunaga Takashi, Seiki Toshio, Sasakabe Tae, Hattori Yuta, Kawai Sayo, Hishida Asahi, Hamajima Nobuyuki, Wakai Kenji

    JOURNAL OF HYPERTENSION   Vol. 34   page: E260 - E260   2016.9

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  25. Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies

    Yuta Hattori, Mariko Naito, Masahiko Satoh, Masahiro Nakatochi, Hisao Naito, Masashi Kato, Sahoko Takagi, Takashi Matsunaga, Toshio Seiki, Tae Sasakabe, Shino Suma, Sayo Kawai, Rieko Okada, Asahi Hishida, Nobuyuki Hamajima, Kenji Wakai

    TOXICOLOGICAL SCIENCES   Vol. 152 ( 1 ) page: 181 - 93   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:OXFORD UNIV PRESS  

    Metallothioneins (MTs) are proteins that protect cells from toxic agents such as heavy metal ions or reactive oxygen species. MT2A A-5G is a single nucleotide polymorphism in the promoter region of the MT2A gene, and the minor G allele results in lower transcription efficiency. We aimed to elucidate associations between MT2A A-5G and risks of 2 diseases potentially related to lowered MT expression, chronic kidney disease (CKD), and diabetes mellitus (DM), in a community-dwelling population. Study subjects were Nagoya city residents participating in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC) Daiko Study, comprised 749 men and 2,025 women, aged 39-75 years. CKD (&gt;stage 3) and DM were defined by standard guidelines. Associations were evaluated using logistic regression models with adjustments for age, sex and potential confounders in a cross-sectional study, and verified in a 5-year longitudinal study. Odds ratios (OR [95% confidence interval]) were calculated relative to the AA genotype. Serum MT (I+II), Cd and zinc levels were also determined by genotype. The OR of the GG genotype for CKD risk was 3.98 (1.50, 10.58) in the cross-sectional study and 5.17 (1.39, 19.28) in the longitudinal study. The OR of the GA genotype for DM was 1.86 (1.26, 2.75) in the cross-sectional study and 2.03 (1.19, 3.46) in the longitudinal study. MT2A A-5G may be associated with CKD and DM risks. This polymorphism is a promising target for evaluations of CKD and DM risks with possible involvement of lowdose chronic exposure to environmental pollutants.

    DOI: 10.1093/toxsci/kfw080

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  26. Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study

    Miwa Yamaguchi, Hirokazu Uemura, Kokichi Arisawa, Sakurako Katsuura-Kamano, Nobuyuki Hamajima, Asahi Hishida, Shino Suma, Isao Oze, Kazuyo Nakamura, Naoyuki Takashima, Sadao Suzuki, Rie Ibusuki, Haruo Mikami, Keizo Ohnaka, Nagato Kuriyama, Michiaki Kubom, Hideo Tanaka

    DIABETES RESEARCH AND CLINICAL PRACTICE   Vol. 110 ( 3 ) page: 301 - 8   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER IRELAND LTD  

    Aims: Brain-muscle-Arnt-like protein-1 (BMAL1) and BMAL2 genes are essential components of the circadian clock, and are considered to be involved in glucose homeostasis. We examined whether single nucleotide polymorphisms (SNPs) of BMAL1 and BMAL2 were associated with the prevalence of type 2 diabetes (T2DM) in the general Japanese population.
    Methods: We studied 2467 subjects (1232 men and 1235 women, 35-69 years old), including 105 men and 57 women with T2DM, from the participants of the Japan Multi-institutional Collaborative Cohort Study. The association between SNPs in the BMAL1 (rs11022775 and rs2290035) and BMAL2 (rs7958822) genes and T2DM were analyzed by multiple logistic regression after adjustment for potential confounders. Analysis was also performed after stratification by body mass index (&gt;= 25 kg/m(2) and &lt;25 kg/m(2)) to investigate an interaction between genotypes and obesity.
    Results: The A/G and A/A genotypes of BMAL2 rs7958822 showed significantly higher adjusted odds ratios (OR) for T2DM than the G/G genotype among obese men (OR = 2.2, 95% confidence intervals [CI] 1.1, 4.6, P for interaction = 0.0495) and obese women (OR = 2.7, 95% CI 1.1, 6.7, P for interaction = 0.199). There were no significant associations between BMAL1 rs11022775 or rs2290035 genotypes and T2DM.
    Conclusions: To the best of our knowledge, this is the first study to show the significant association between BMAL2 rs7958822 genotype and T2DM among obese subjects. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

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  27. ATP-binding cassette transporter A1 (ABCA1) R219K (G1051A, rs2230806) polymorphism and serum high-density lipoprotein cholesterol levels in a large Japanese population: cross-sectional data from the Daiko Study

    Mokuno Junichiro, Hishida Asahi, Morita Emi, Sasakabe Tae, Hattori Yuta, Suma Shino, Okada Rieko, Kawai Sayo, Naito Mariko, Wakai Kenji

    ENDOCRINE JOURNAL   Vol. 62 ( 6 ) page: 543 - 549   2015.6

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  28. Hyperbaric area index calculated from ABPM elucidates the condition of CKD patients: the CKD-JAC study

    Iimuro Satoshi, Imai Enyu, Watanabe Tsuyoshi, Nitta Kosaku, Akizawa Tadao, Matsuo Seiichi, Makino Hirofumi, Ohashi Yasuo, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 19 ( 1 ) page: 114 - 124   2015.2

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    DOI: 10.1007/s10157-014-0965-2

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  29. ATP-binding cassette transporter A1 (ABCA1) R219K (G1051A, rs2230806) polymorphism and serum high-density lipoprotein cholesterol levels in a large Japanese population: cross-sectional data from the Daiko Study

    Junichiro Mokuno, Asahi Hishida, Emi Morita, Tae Sasakabe, Yuta Hattori, Shino Suma, Rieko Okada, Sayo Kawai, Mariko Naito, Kenji Wakai

    ENDOCRINE JOURNAL   Vol. 62 ( 6 ) page: 543 - 9   2015

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    Among polymorphisms in ATP-binding cassette transporter A1 (ABCA1) gene, the available evidence demonstrates that the ABCA1 R219K polymorphism (G1051A, rs2230806) K allele is associated with a higher high-density lipoprotein cholesterol (HDL-C) level and may play a protective role against coronary artery disease (CAD) risk in Asians and Caucasians. The findings from many underpowered studies from Asian countries (n=71-597), however, still remain inconsistent. The objective of this study was to overcome the limitations of previous studies in Asia and provide solid epidemiologic evidence. Subjects were participants of a cohort study, who visited the Daiko Medical Center in Nagoya, Japan. The cohort study belongs to the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). In the Daiko Study, 5,133 participants (1,458 men and 3,675 women) aged 35-69 years enrolled from 2008 through 2010 were eligible for the analyses. The ABCA1 polymorphism was genotyped by the polymerase chain reaction with confronting two-pair primers (PCR-CTPP) method. Among all the subjects, the genotype frequencies were 23.9% (n=1,225) for RR, 49.3% (n=2,532) for RK, and 26.8% (n=1,376) for KK, which was in Hardy-Weinberg's equilibrium (P=0.36). Background characteristics did not significantly differ among the genotypes including alcohol and tobacco use. The mean +/- SD of HDL-C concentration was higher in men and women with RK or KK genotype than those with RR, although the difference between these genotypes was not statistically significant in both sexes (P=0.31 in men and 0.26 in women by ANOVA). In the multiple linear regression analysis to estimate the independent effects of the R219K polymorphism on HDL-C level, however, the number of K allele was significantly correlated with an increased level of HDL-C (trend P=0.033). Those with the KK genotype showed a significantly higher HDL-C concentration compared with those with the RR genotype by a mean of 1.18 mg/dL. The R219K polymorphism of ABCA1 independently associated with serum level of HDL-C in a large Japanese population.

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  30. Validation of the General Oral Health Assessment (GOHAI) Index into Japanese adults

    Naito Mariko, Suzukamo Yoshimi, Suma Shino, Kawai Sayo, Okada Rieko, Hishida Asahi, Morita Emi, Hamajima Nobuyuki, Wakai Kenji

    QUALITY OF LIFE RESEARCH   Vol. 23   page: 173 - 173   2014.10

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  31. Taming the chronic kidney disease epidemic: a global view of surveillance efforts

    Radhakrishnan Jai, Remuzzi Giuseppe, Saran Rajiv, Williams Desmond E., Rios-Burrows Nilka, Powe Neil, Bruck Katharina, Wanner Christoph, Stel Vianda S., Venuthurupalli Sree K., Hoy Wendy E., Healy Helen G., Salisbury Anne, Fassett Robert G., O'Donoghue Donal, Roderick Paul, Matsuo Seiichi, Hishida Akira, Imai Enyu, Iimuro Satoshi, Consortium European C. K. D. Burden, Grp C. K. D. Q. L. D.

    KIDNEY INTERNATIONAL   Vol. 86 ( 2 ) page: 246 - 250   2014.8

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    Chronic kidney disease is now recognized to be a worldwide problem associated with significant morbidity and mortality and there is a steep increase in the number of patients reaching end-stage renal disease. In many parts of the world, the disease affects younger people without diabetes or hypertension. The costs to family and society can be enormous. Early recognition of CKD may help prevent disease progression and the subsequent decline in health and longevity. Surveillance programs for early CKD detection are beginning to be implemented in a few countries. In this article, we will focus on the challenges and successes of these programs with the hope that their eventual and widespread use will reduce the complications, deaths, disabilities, and economic burdens associated with CKD worldwide. © 2014 International Society of Nephrology.

    DOI: 10.1038/ki.2014.190

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  32. GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: data from the J-MICC Study

    Asahi Hishida, Naoyuki Takashima, Tanvir Chowdhury Turin, Sayo Kawai, Kenji Wakai, Nobuyuki Hamajima, Satoyo Hosono, Yuichiro Nishida, Sadao Suzuki, Noriko Nakahata, Haruo Mikami, Keizo Ohnaka, Daisuke Matsui, Sakurako Katsuura-Kamano, Michiaki Kubo, Hideo Tanaka, Yoshikuni Kita

    JOURNAL OF NEPHROLOGY   Vol. 27 ( 2 ) page: 143 - 9   2014.4

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    Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of glucokinase and glucokinase regulatory protein (GCKR) polymorphisms with the risk of CKD in Japan, we examined this association among Japanese individuals using cross-sectional data.
    The subjects for this analysis were 3,314 consecutively selected participants from the Japan Multi-Institutional Collaborative Cohort Study. Age- and sex- adjusted odds ratios (aORs) of CKD stages 3-5 were calculated for each genotype by logistic regression and the effects of genotype on estimated glomerular filtration rate were evaluated by linear regression. Gene-environment interaction was also investigated based on questionnaire information.
    When subjects with GCKR rs780094 G/A and G/G, or GCKR rs1260326 T/C and C/C were combined together and compared with the references (GCKR rs780094 A/A or GCKR rs1260326 T/T), the aORs were 0.84 (0.69-1.02) or 0.81 (0.67-0.99) (p = 0.075 or 0.037), respectively. A significant OR for interaction between GCKR rs1260326 T/T and current smoking (OR = 1.79, p = 0.041) was also observed.
    The present study suggests a possible association of the T/T genotype of GCKR rs1260326 polymorphism with elevated risk of CKD and its interaction with current smoking, which may support the possibility of performing risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.

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  33. A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility

    Akiyoshi Nakayama, Hirotaka Matsuo, Takuya Shimizu, Hiraku Ogata, Yuzo Takada, Hiroshi Nakashima, Takahiro Nakamura, Seiko Shimizu, Toshinori Chiba, Masayuki Sakiyama, Chisaki Ushiyama, Tappei Takada, Katsuhisa Inoue, Sayo Kawai, Asahi Hishida, Kenji Wakai, Nobuyuki Hamajima, Kimiyoshi Ichida, Yutaka Sakurai, Yukio Kato, Toru Shimizu, Nariyoshi Shinomiya

    Human Cell   Vol. 26 ( 4 ) page: 133 - 6   2013.12

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    Gout is a common disease caused by hyperuricemia, which shows elevated serum uric acid (SUA) levels. From a viewpoint of urate handling in humans, gout patients can be divided into those with renal overload (ROL) gout with intestinal urate underexcretion, and those with renal underexcretion (RUE) gout. Recent genome-wide association studies (GWAS) revealed an association between SUA and a variant in human monocarboxylate transporter 9 (MCT9/SLC16A9) gene. Although the function of MCT9 remains unclear, urate is mostly excreted via intestine and kidney where MCT9 expression is observed. In this study, we investigated the relationship between a variant of MCT9 and gout in 545 patients and 1,115 healthy volunteers. A missense variant of MCT9 (K258T), rs2242206, significantly increased the risk of ROL gout (p = 0.012), with odds ratio (OR) of 1.28, although it revealed no significant association with all gout cases (p = 0.10), non-ROL gout cases (p = 0.83), and RUE gout cases (p = 0.34). In any case groups and the control group, minor allele frequencies of rs2242206 were &gt
    0.40. Therefore, rs2242206 is a common missense variant and is revealed to have an association with ROL gout, indicating that rs2242206 relates to decreased intestinal urate excretion rather than decreased renal urate excretion. Our study provides clues to better understand the pathophysiology of gout as well as the physiological roles of MCT9. © 2013 The Author(s).

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  34. A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility

    Nakayama A.

    Human Cell   Vol. 26 ( 4 ) page: 133 - 136   2013.12

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    DOI: 10.1007/s13577-013-0073-8

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  35. A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility

    Nakayama Akiyoshi, Matsuo Hirotaka, Shimizu Takuya, Ogata Hiraku, Takada Yuzo, Nakashima Hiroshi, Nakamura Takahiro, Shimizu Seiko, Chiba Toshinori, Sakiyama Masayuki, Ushiyama Chisaki, Takada Tappei, Inoue Katsuhisa, Kawai Sayo, Hishida Asahi, Wakai Kenji, Hamajima Nobuyuki, Ichida Kimiyoshi, Sakurai Yutaka, Kato Yukio, Shimizu Toru, Shinomiya Nariyoshi

    HUMAN CELL   Vol. 26 ( 4 ) page: 133 - 136   2013.12

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  36. A NEW INDICATOR CALCULATED FROM ABPM ELUCIDATES THE RELATION BETWEEN ANTIHYPERTENSIVE PRESCRIBING AND BLOOD PRESSURE LOAD; FROM THE CKD-JAC STUDY

    Iimuro Satoshi, Imai Enyu, Matsuo Seiichi, Watanabe Tsuyoshi, Nitta Kosaku, Akizawa Tadao, Makino Hirofumi, Ohashi Yasuo, Hishida Akira

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 28   page: 330 - 330   2013.5

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  37. Clinical Correlates of Ambulatory BP Monitoring among Patients with CKD

    Iimuro Satoshi, Imai Enyu, Watanabe Tsuyoshi, Nitta Kosaku, Akizawa Tadao, Matsuo Seiichi, Makino Hirofumi, Ohashi Yasuo, Hishida Akira

    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   Vol. 8 ( 5 ) page: 721 - 730   2013.5

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    DOI: 10.2215/CJN.06470612

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  38. Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese - The J-MICC Study

    Hishida A., Wakai K., Okada R., Morita E., Hamajima N., Hosono S., Higaki Y., Turin T.C., Suzuki S., Motahareh K., Mikami H., Tashiro N., Watanabe I., Katsuura S., Kubo M., Tanaka H., Naito M.

    Endocrine Journal   Vol. 60 ( 2 ) page: 237 - 243   2013.3

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    We examined the association of the RETN (resistin) -420 C>G polymorphism (rs1862513) with risk of diabetes mellitus (DM), considering lifestyle factors, in Japanese. Subjects were participants of J-MICC Study, where 2,651 participants aged 35-69 years provided their blood for genotyping and lifestyle data after informed consent. Odds ratio (OR) of DM for RETN-420 G/G genotype was estimated using unconditional logistic regression model. Statistically significant interaction on risk of DM was observed between RETN-420 G/G genotype and BMI<25 (OR for interaction = 0.12; P = 0.046), and when subjects with RETN-420 C/C+C/G and BMI ≥ 25 (n = 69 for DM and 544 for non-DM) were defined as the reference, the adjusted ORs for subjects with RETN-420 G/G genotype and BMI>25 (n = 10 for DM and 111 for non- DM), RETN-420 C/C+C/G and BMI<25 (n = 81 for DM and 1,605 for non-DM), and RETN-420 G/G and BMI < 25 (n = 1 for DM and 230 for non-DM) were demonstrated to be 0.72 (95% confidence interval: 0.36-1.46), 0.40 (0.28-0.56) and 0.03 (0.005-0.25), respectively. The present study revealed the significant interaction of RETN-420 G/G genotype with lower BMI on the decreased risk of DM, but the direction was opposite to the reported ones in Japanese. We should be careful in interpretation of the present study results because of the limited sample sizes. Further investigation of this association as well as of the actual biological roles of RETN in the genesis of human metabolic disorders including DM will be required. ©The Japan Endocrine Society.

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  39. Association of obesity and diabetes with serum prostate-specific antigen levels in Japanese males

    Naito M.

    Nagoya Journal of Medical Science   Vol. 74 ( 3-4 ) page: 285 - 292   2012.12

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  40. Prevalence of helicobacter pylori infection measured with urinary antibody in an urban area of japan, 2008-2010

    Tamura T.

    Nagoya Journal of Medical Science   Vol. 74 ( 1-2 ) page: 63 - 70   2012.12

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  41. Association of obesity and diabetes with serum prostate-specific antigen levels in Japanese males

    Mariko Naito, Yatami Asai, Atsuyoshi Mori, Yuko Fukada, Mayumi Kuwabara, Shiro Katase, Asahi Hishida, Emi Morita, Sayo Kawai, Rieko Okada, Kazuko Nishio, Akiko Tamakoshi, Kenji Wakai, Nobuyuki Hamajima

    Nagoya Journal of Medical Science   Vol. 74 ( 3-4 ) page: 285 - 92   2012.8

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    Patients with diabetes have been reported to be at an increased risk for cancers of the pancreas, liver, and colon
    however, recent studies have suggested that men with diabetes are at a decreased risk for prostate cancer. Previous studies have found that obese men have lower serum prostate-specific antigen (PSA) concentrations than do non-obese men. Further understanding of how obesity and diabetes affect the PSA concentration may improve our ability to detect clinically relevant prostate tumors. This study examined the relationships among serum PSA level, obesity, and diabetes in apparently healthy Japanese males. We analyzed the baseline data from 2,172 Japanese males (age, 56.8 ± 6.1 years [mean ± SD]) who participated in the Japan Multi-Institutional Collaborative Cohort Study. Diabetes was defined as the presence of both a hemoglobin A1c (JDS) of =6.1% and a fasting plasma glucose level of =126 mg/dL, or a positive medical history. After adjusting for age, the PSA levels were elevated among males with a higher normal BMI (ranging from 23.0 to 24.9) and lowered among men with a BMI of =25.0. In the stratified analysis, these significant differences in BMI categories were absent among diabetics. The mean PSA levels were significantly lower in diabetics than in non-diabetics among subjects aged 60 and over. Our findings suggest that the pre-overweight men had increased PSA levels, and the diabetes was associated with a reduction of PSA levels in elderly.

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  42. ASSOCIATION OF OBESITY AND DIABETES WITH SERUM PROSTATE-SPECIFIC ANTIGEN LEVELS IN JAPANESE MALES

    Naito Mariko, Asai Yatami, Mori Atsuyoshi, Fukada Yuko, Kuwabara Mayumi, Katase Shiro, Hishida Asahi, Morita Emi, Kawai Sayo, Okada Rieko, Nishio Kazuko, Tamakoshi Akiko, Wakai Kenji, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 74 ( 3-4 ) page: 285 - 292   2012.8

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  43. Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study

    Hishida Asahi, Morita Emi, Naito Mariko, Okada Rieko, Wakai Kenji, Matsuo Keitaro, Nakamura Kazuyo, Takashima Naoyuki, Suzuki Sadao, Takezaki Toshiro, Mikami Haruo, Ohnaka Keizo, Watanabe Yoshiyuki, Uemura Hirokazu, Kubo Michiaki, Tanaka Hideo, Hamajima Nobuyuki

    ENDOCRINE JOURNAL   Vol. 59 ( 7 ) page: 589 - 599   2012.7

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  44. STUDY PROFILE ON BASELINE SURVEY OF DAIKO STUDY IN THE JAPAN MULTI-INSTITUTIONAL COLLABORATIVE COHORT STUDY (J-MICC STUDY)

    Morita Emi, Hamajima Nobuyuki, Hishida Asahi, Aoyama Kyoko, Okada Rieko, Kawai Sayo, Tomita Koutaro, Kuriki Sayaka, Tamura Takashi, Naito Mariko, Kondo Takaaki, Ueyama Jun, Kimata Akiko, Yamamoto Kanami, Hori Yoko, Hoshino Junko, Hamamoto Ritsuko, Tsukamoto Sanae, Onishi Joji, Hagikura Shoichi, Naito Hisao, Hibi Satoshi, Ito Yoshinori, Wakai Kenji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 73 ( 3-4 ) page: 187 - 195   2011.8

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  45. Management of anemia in chronic kidney disease patients: baseline findings from Chronic Kidney Disease Japan Cohort Study

    Akizawa Tadao, Makino Hirofumi, Matsuo Seiichi, Watanabe Tsuyoshi, Imai Enyu, Nitta Kosaku, Ohashi Yasuo, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 15 ( 2 ) page: 248 - 257   2011.4

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    DOI: 10.1007/s10157-010-0396-7

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  46. ASSOCIATION OF UGT1A1 GLY71ARG WITH URINE UROBILINOGEN

    Kataoka Ryuji, Kimata Akiko, Yamamoto Kanami, Hirosawa Naoko, Ueyama Jun, Kondo Takaaki, Okada Rieko, Kawai Sayo, Hishida Asahi, Naito Mariko, Morita Emi, Wakai Kenji, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 73 ( 1-2 ) page: 33 - 40   2011.2

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  47. Association of UGT1A1 Gly71Arg with urine urobilinogen.

    Kataoka R.

    Nagoya journal of medical science   Vol. 73 ( 1-2 ) page: 33 - 40   2011.2

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  48. Chronic Kidney Disease Japan Cohort study: baseline characteristics and factors associated with causative diseases and renal function

    Imai Enyu, Matsuo Seiichi, Makino Hirofumi, Watanabe Tsuyoshi, Akizawa Tadao, Nitta Kosaku, Iimuro Satoshi, Ohashi Yasuo, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 14 ( 6 ) page: 558 - 570   2010.12

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    DOI: 10.1007/s10157-010-0328-6

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  49. Erratum: Chronic Kidney Disease Japan Cohort study: Baseline characteristics and factors associated with causative diseases and renal function (Clin Exp Nephrol DOI: 10.1007/s10157-010-0328-6)

    Imai E.

    Clinical and Experimental Nephrology   Vol. 14 ( 6 ) page: 571 - 572   2010.12

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    DOI: 10.1007/s10157-010-0352-6

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  50. Smoking Behavior and Risk of Helicobacter Pylori Infection, Gastric Atrophy and Gastric Cancer in Japanese

    Hishida Asahi, Matsuo Keitaro, Goto Yasuyuki, Naito Mariko, Wakai Kenji, Tajima Kazuo, Hamajima Nobuyuki

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   Vol. 11 ( 2 ) page: 313 - 317   2010

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  51. A large-scale survey of health check-up visitors in the West-Central area of Shizuoka Prefecture regarding the frequency of walking in forested areas

    Morita E.

    Nihon Ringakkai Shi/Journal of the Japanese Forestry Society   Vol. 92 ( 2 ) page: 110 - 114   2010

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    DOI: 10.4005/jjfs.92.110

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  52. Erratum to: Prevalence of chronic kidney disease in the Japanese general population (Clinical and Experimental Nephrology DOI: 10.1007/s10157-009-0199-x)

    Imai E.

    Clinical and Experimental Nephrology   Vol. 13 ( 6 ) page: 631 - 632   2009.12

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    DOI: 10.1007/s10157-009-0238-7

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  53. Prevalence of chronic kidney disease in the Japanese general population

    Imai Enyu, Horio Masaru, Watanabe Tsuyoshi, Iseki Kunitoshi, Yamagata Kunihiro, Hara Shigeko, Ura Nobuyuki, Kiyohara Yutaka, Moriyama Toshiki, Ando Yasuhiro, Fujimoto Shoichi, Konta Tsuneo, Yokoyama Hitoshi, Makino Hirofumi, Hishida Akira, Matsuo Seiichi

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 13 ( 6 ) page: 621 - 630   2009.12

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    DOI: 10.1007/s10157-009-0199-x

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  54. BASELINE DATA OF SHIZUOKA AREA IN THE JAPAN MULTI-INSTITUTIONAL COLLABORATIVE COHORT STUDY (J-MICC STUDY)

    Asai Yatami, Naito Mariko, Suzuki Masumi, Tomoda Akiko, Kuwabara Mayumi, Fukada Yuko, Okamoto Ayumi, Oishi Sachie, Ikeda Kanako, Nakamura Tsukino, Misu Yasuko, Katase Shiroh, Tokumasu Satoshi, Nishio Kazuko, Ishida Yoshiko, Hishida Asahi, Morita Emi, Kawai Sayo, Okada Rieko, Wakai Kenji, Tamakoshi Akiko, Hamajima Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 71 ( 3-4 ) page: 137 - 144   2009.9

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  55. Applicability of Allele/genotype Frequency from Documented Controls for Case-Control Studies on Genotypes among Japanese: MTHFR C677T as an Example

    Kenta Iida, Koutaro Tomita, Rieko Okada, Sayo Kawai, Emi Morita, Asahi Hishida, Mariko Naito, Kenji Wakai, Nobuyuki Hamajima

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   Vol. 10 ( 2 ) page: 231 - 6   2009.4

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    In a case-control study, controls have to be selected from the population where cases are identified. However, there is an idea to make common controls applicable for different case-control studies, which could reduce study costs. This study compared methylenetetrahydrofolate reductase C677T among subjects from different studies, to examine the applicability of combined subjects as controls. Case-control studies and cross-sectional studies with more than 100 Japanese controls or subjects were selected from PubMed in December 2008. Between 1996 and 2008, 31 eligible studies with 14,510 subjects in total were published; the 677T allele frequency varied from 0.300 to 0.438. The genotype frequencies were all in Hardy-Weinberg equilibrium. The average weighted with the number of subjects was 0.385. The 95% confidence interval (95% CI) of 10 studies did not include the weighted average. The study whose proximal limit of 95% CI was furthest from the weighted average was removed, and then the weighted average was recalculated. Through the process, 7 studies were excluded, resulting in the remaining 24 studies having a 95% CI including the weighted average (0.391) with 10,854 subjects. Of the 7 excuded studies, one was from patients enrolled in a clinical study (0.431), two were relatively isolated (0.300 and 0.438), two were published ten years ago (0.315 and 0.334), one was from a study whose allele frequency of female subjects was 0.382 (0.436), and one had a large sample size (0.360). This example demonstrated that the allele frequency of MTHFR 677T was in common among 24 out of 31 Japanese studies, suggesting that the calculated allele frequency could be used for Japanese case-control studies, whose cases are sampled in a general population.

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  56. Applicability of allele/genotype frequency from documented controls for case-control studies on genotypes among Japanese: MTHFR C677T as an example

    Iida K.

    Asian Pacific Journal of Cancer Prevention   Vol. 10 ( 2 ) page: 231 - 236   2009

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  57. Applicability of Allele/genotype Frequency from Documented Controls for Case-Control Studies on Genotypes among Japanese: MTHFR C677T as an Example

    Iida Kenta, Tomita Koutaro, Okada Rieko, Kawai Sayo, Morita Emi, Hishida Asahi, Naito Mariko, Wakai Kenji, Hamajima Nobuyuki

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   Vol. 10 ( 2 ) page: 231 - 236   2009

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  58. Controls for monitoring the deterioration of stored blood samples in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study).

    Naito M.

    Nagoya journal of medical science   Vol. 70 ( 3-4 ) page: 107 - 115   2008.8

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  59. Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products

    Makino T.

    Journal of Natural Medicines   Vol. 62 ( 3 ) page: 294 - 299   2008.7

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    DOI: 10.1007/s11418-008-0230-7

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  60. Chronic Kidney Disease Japan Cohort (CKD-JAC) study: Design and methods

    Imai Enyu, Matsuo Seiichi, Makino Hirofumi, Watanabe Tsuyoshi, Akizawa Tadao, Nitta Kosaku, Iimuro Satoshi, Ohashi Yasuo, Hishida Akira

    HYPERTENSION RESEARCH   Vol. 31 ( 6 ) page: 1101 - 1107   2008.6

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  61. Chronic kidney disease Japan cohort (CKD-JAC) Study: Design and methods

    Imai E.

    Hypertension Research   Vol. 31 ( 6 ) page: 1101 - 1107   2008.6

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    DOI: 10.1291/hypres.31.1101

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  62. Chronic kidney disease perspectives in Japan and the importance of urinalysis screening

    Yamagata Kunihiro, Iseki Kunitoshi, Nitta Kousaku, Imai Hirokazu, Iino Yasuhiko, Matsuo Seiichi, Makino Hirofumi, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 12 ( 1 ) page: 1 - 8   2008.2

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    DOI: 10.1007/s10157-007-0010-9

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  63. Modification of the Modification of Diet in Renal Disease (MDRD) Study equation for Japan

    Imai Enyu, Horio Masaru, Nitta Kosaku, Yamagata Kunihiro, Iseki Kunitoshi, Tsukamoto Yusuke, Ito Sadayoshi, Makino Hirofumi, Hishida Akira, Matsuo Seiichi

    AMERICAN JOURNAL OF KIDNEY DISEASES   Vol. 50 ( 6 ) page: 927 - 937   2007.12

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    DOI: 10.1053/j.ajkd.2007.09.004

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  64. Kidney disease screening program in japan: History, outcome, and perspectives

    Imai Enyu, Yamagata Kunihiro, Iseki Kunitoshi, Iso Hiroyasu, Horio Masaru, Mkino Hirofumi, Hishida Akira, Matsuo Seiichi

    CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   Vol. 2 ( 6 ) page: 1360 - 1366   2007.11

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    DOI: 10.2215/CJN.00980207

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  65. Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy

    Hitoshi Zembutsu, Masamitsu Yanada, Asahi Hishida, Toyomasa Katagiri, Takashi Tsuruo, Isamu Sugiura, Jin Takeuchi, Noriko Usui, Tomoki Naoe, Yusuke Nakamura, Ryuzo Ohno

    INTERNATIONAL JOURNAL OF ONCOLOGY   Vol. 31 ( 2 ) page: 313 - 22   2007.8

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    Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) reveals very poor prognosis due to high incidence of relapse when treated with standard chemotherapy. Although &gt; 96% of patients with Ph+ALL achieved complete remission (CR) with imatinib-combined chemotherapy in a phase II clinical trial conducted by the Japan Adult Leukemia Study Group (JALSG), 26% of them experienced hematological relapse in a short time after achievement of CR. In this study, to establish a prediction system for risk of relapse, we analyzed gene expression profiles of 23 bone marrow samples from patients with Ph+ALL usina cDNA microarray consisting of 27,648 cDNA sequences. Using the 19 randornly-selected test cases, we identified 16 genes that were expressed significantly differently between patients with (n=8) and without (n=11) continuous response; from the list of 16 genes, we selected the 6 &apos;predictive&apos; genes and constructed a numerical scoring system by which the two groups were clearly separated, with positive scores for the former and the negative scores for the latter. Scoring of 4 cases that were reserved from the original 23 cases predicted correctly their clinical responses. In addition, three cases whose BCR-Abl transcript levels failed to reduce sufficiently after induction therapy, also revealed negative scores. We also developed a quantitative reverse transcription-PCR-based prediction system that could be feasible for routine clinical use. Our results suggest that achievement of continuous response with imatinib-combined chemotherapy can be predicted by expression patterns in this set of genes, leading to achievement of &apos;personalized therapy&apos; for treatment of this disease.

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  66. Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy

    Zembutsu Hitoshi, Yanada Masamitsu, Hishida Asahi, Katagiri Toyomasa, Tsuruo Takashi, Sugiura Isamu, Takeuchi Jin, Usui Noriko, Naoe Tomoki, Nakamura Yusuke, Ohno Ryuzo

    INTERNATIONAL JOURNAL OF ONCOLOGY   Vol. 31 ( 2 ) page: 313 - 322   2007.8

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  67. Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy

    Zembutsu H.

    International Journal of Oncology   Vol. 31 ( 2 ) page: 313 - 322   2007.8

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    DOI: 10.3892/ijo.31.2.313

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  68. Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient

    Imai E.

    Clinical and Experimental Nephrology   Vol. 11 ( 2 ) page: 156 - 163   2007.6

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    DOI: 10.1007/s10157-007-0463-x

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  69. Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease

    Imai E.

    Clinical and Experimental Nephrology   Vol. 11 ( 1 ) page: 41 - 50   2007.3

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    DOI: 10.1007/s10157-006-0453-4

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  70. Associations between serum C-reactive protein (CRP) levels and polymorphisms of CRP, interleukin 1B, and tumor necrosis factor genes among Japanese health checkup examinees

    Masato Kikuchi, Asahi Hishida, Kohei Ishikawa, Hiroe Sagawa, Koji Suzuki, Yoshinori Ito, Hiroko Terasaki, Nobuyuki Hamajima

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   Vol. 8 ( 1 ) page: 87 - 92   2007.1

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    C-reactive protein (CRP) is a sensitive marker of acute inflammation, which is associated with risk of cardiovascular and other chronic diseases. Some CRP polymorphisms are reported to affect the basal and stimulated CRP levels. Thus we conducted a population -based cross-sectional study to examine the associations of CRP levels with CRP C1444T polymorphism and two cytokine polymorphisms IL-1B C-31T and TNF-A T-1031C), according to sex, age, smoking, alcohol, and BMI, in a total of 489 Japanese health checkup examinees (156 males and 333 females). Serum CRP levels were measured by high sensitivity latex-enhanced nephelometry. CRP C1444T, IL-1B C-31T and TNF-A T-1031C genotypes were genotyped by PCR-CTPP (polymerase chain reaction with confronting two-pair primers). Males, aged, smokers, and those with high BMI had a higher CRP on average. All genotype frequencies among the 489 subjects were in Hardy-Weinberg equilibrium. No significant associations of serum CRP levels with the genotypes of CRP C1444T and IL-1B C-31T were observed. TNF-A-1031CC polymorphism was significantly associated with high CRP values. For the females, those aged 61-69 years, never smokers, non-drinkers, or those with body mass index 24 or less, the association was remarkable. Since the biological mechanism is not clear, further investigations are required to confirm the association.

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  71. Associations between serum C-reactive Protein (CRP) Levels and Polymorphisms of CRP, Interleukin 1B, and tumor necrosis factor genes among Japanese health checkup examinees

    Kikuchi M.

    Asian Pacific Journal of Cancer Prevention   Vol. 8 ( 1 ) page: 87 - 92   2007

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  72. Associations between serum C-reactive protein (CRP) levels and polymorphisms of CRP, interleukin 1B, and tumor necrosis factor genes among Japanese health checkup examinees

    Kikuchi Masato, Hishida Asahi, Ishikawa Kohei, Sagawa Hiroe, Suzuki Koji, Ito Yoshinori, Terasaki Hiroko, Hamajima Nobuyuki

    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION   Vol. 8 ( 1 ) page: 87 - 92   2007

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  73. BMI-1 overexpression in 32Dcl3 cells suppresses granulocytic differentiation and ameliorates their growth under IL-3 diminished conditions.

    Hishida A, Yamamoto K, Sawa M, Naoe T

    BLOOD   Vol. 106 ( 11 ) page: 133B - 133B   2005.11

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  74. GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese

    Asahi Hishida, Seitaro Terakura, Nobuhiko Emi, Kazuhito Yamamoto, Makoto Murata, Kazuko Nishio, Yoshitaka Sekido, Toshimitsu Niwa, Nobuyuki Hamajima, Tomoki Naoe

    Asian Pacific Journal of Cancer Prevention   Vol. 6 ( 3 ) page: 251 - 5   2005.7

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    We conducted a prevalent case-control study with 51 chronic myelogenous leukemia (CML) cases and 476 controls to investigate the associations between glutathione S-transferase T1 (GSTT1), glutathione S-transferase M1 (GSTM1) deletions, and the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism with risk of chronic myelocytic leukemia in Japanese. For the GSTT1 deletion, when the GSTT1 positive genotype was defined as the reference, the OR for the GSTT1 deletion genotype was 1.32 (95%CI
    0.74-2.36). For the GSTM1 deletion, when the GSTM1 positive genotype was defined as the reference, the OR for the GSTM1 deletion genotype was 0.95 (95%CI
    0.53- 1.69). For NQO1 C609T polymorphism, when the NQO1 609CC genotype was defined as the reference, the ORs for the CT genotype, TT genotype, and CT and TT genotypes combined together were 2.37 (95%CI, 1.21-4.67, P=0.012), 1.44 (0.55-3.74, P=0.012) and 2.12 (1.10-4.08, P=0.025), respectively. The present study revealed that the risk of CML was modulated little by GSTT1 and GSTM1 deletions, but a statistically significant association between NQO1 C609T polymorphism and CML was observed for Japanese. Incidence case-control studies with a larger statistical power are now required to confirm our findings.

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  75. Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese.

    Tanaka D.

    Nagoya journal of medical science   Vol. 67 ( 3-4 ) page: 117 - 124   2005.6

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  76. Transcriptional induction of Smurf2 ubiquitin ligase by TGF-β

    Ohashi N., Yamamoto T., Uchida C., Togawa A., Fukasawa H., Fujigaki Y., Suzuki S., Kitagawa K., Hattori T., Oda T., Hayashi H., Hishida A., Kitagawa M.

    FEBS Letters   Vol. 579 ( 12 ) page: 2557 - 2563   2005.5

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    Smad ubiquitination regulatory factor 2 (Smurf2), a ubiquitin ligase for Smads, plays critical roles in the regulation of transforming growth factor-β (TGF-β)-Smad signaling via ubiquitin-dependent degradation of Smad2 and Smad7. We found that TGF-β stimulates Smurf2 expression. TGF-β activated the Smurf2 promoter in a TGF-β responsive cell lines, whereas IL-1α, PDGF and epidermal growth factor did not. TGF-β-mediated Smurf2 promoter activation was inhibited by Smad7 or an activin receptor-like kinase 5 inhibitor but not by dominant negative Smad or disruption of Smad-binding elements in the promoter. Moreover, inhibition of the phosphatidil inositol 3 kinase (PI3K)/Akt pathway suppressed TGF-β-mediated Smurf2 induction. These results suggest that TGF-β stimulates Smurf2 expression by Smad-independent pathway such as PI3K/Akt pathway via TGF-β receptor. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.febslet.2005.03.069

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  77. GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese

    Hishida A.

    Asian Pacific Journal of Cancer Prevention   Vol. 6 ( 3 ) page: 251 - 255   2005

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  78. A randomized open-label comparative study of conventional therapy versus mizoribine onlay therapy in patients with steroid-resistant nephrotic syndrome (postmarketing survey)

    Shibasaki T.

    Clinical and Experimental Nephrology   Vol. 8 ( 2 ) page: 117 - 126   2004.6

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    DOI: 10.1007/s10157-004-0276-0

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  79. Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma

    A Hishida, K Matsuo, N Hamajima, H Ito, M Ogura, Y Kagami, H Taji, Y Morishima, N Emi, K Tajima

    HAEMATOLOGICA   Vol. 88 ( 2 ) page: 159 - 66   2003.2

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    Background and Objectives. Polymorphisms in thymidylate synthase (TS) 28-by tandem repeats in the promoter region and in cytosolic serine hydroxymethyltransferase (SHMT1 C1420T) have been reported to modulate the risk of adult acute lymphocytic leukemia (ALL). We examined the associations between susceptibility to malignant lymphoma and these polymorphisms.
    Design and Methods. A hospital-based prevalent case-control study was conducted in Aichi Cancer Center. One hundred and eight patients with histologically confirmed lymphoma and 494 control subjects without cancer were evaluated.
    Results. In a risk estimation of each genotype, those who harbored at least one TS 2 repeat (213) allele had a 1.6-fold increase in the risk of malignant lymphoma (OR=1.63; 95%Cl, 1.05-2.53, p=0.030) when using those without the TS 213 allele as a reference. For the SHMT1 C1420T polymorphism, those harboring at least one T allele showed a 2.2-fold decrease in risk (OR=0.46; 95% Cl, 0.23-0.93, p=0.031). Moreover, combined analysis of TS and SHMT1 polymorphisms revealed that the OR for lymphoma in patients with SHMT1 1420 CC and the TS 213 allele, which might be expected to provide the basis for the highest susceptibility, was 2.88 (95% Cl, 1.26-6.58, p=0.013).
    Interpretations and Conclusions. This study suggests that genetic traits involving low penetrance polymorphisms in folate-metabolizing genes may modulate the risk of malignant lymphoma.

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  80. Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma

    Hishida A, Matsuo K, Hamajima N, Ito H, Ogura M, Kagami Y, Taji H, Morishima Y, Emi N, Tajima K

    HAEMATOLOGICA   Vol. 88 ( 2 ) page: 159 - 166   2003.2

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  81. Sex-specific Relationship between Stress Coping Strategies and All-Cause Mortality: Japan Multi-Institutional Collaborative Cohort Study.

    Mako Nagayoshi, Kenji Takeuchi, Yudai Tamada, Kato Yasufumi, Yoko Kubo, Rieko Okada, Takashi Tamura, Asahi Hishida, Jun Otonari, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Yuriko N Koyanagi, Keitaro Matsuo, Mikami Haruo, Kusakabe Miho, Daisaku Nishimoto, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Wakai

    Journal of epidemiology     2021.9

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    BACKGROUND: Stress coping strategies are related to health outcomes. However, there is no clear evidence for sex differences between stress-coping strategies and mortality. We investigated the relationship between all-cause mortality and stress-coping strategies, focusing on sex differences among Japanese adults. METHODS: A total of 79,580 individuals aged 35-69 years participated in the Japan Multi-Institutional Collaborative Cohort Study between 2004 and 2014 and were followed up for mortality. The frequency of use of the five coping strategies was assessed using a questionnaire. Sex-specific, multivariable-adjusted hazard ratios (HRs) for using each coping strategy "sometimes," and "often/very often" (versus "very few" use) were computed for all-cause mortality. Furthermore, relationships were analyzed in specific follow-up periods when the proportion assumption was violated. RESULTS: During the follow-up (median: 8.5 years), 1,861 mortalities were recorded. In women, three coping strategies were related to lower total mortality. The HRs (95% confidence intervals) for "sometimes" were 0.81 (0.67-0.97) for emotional expression, 0.79 (0.66-0.95) for emotional support-seeking, and 0.80 (0.66-0.98) for disengagement. Men who "sometimes" used emotional expression and sometimes or often used problem-solving and positive reappraisal had a 15-41% lower HRs for all-cause mortality. However, those relationships were dependent on the follow-up period. There was evidence that sex modified the relationships between emotional support-seeking and all-cause mortality (p for interaction = 0.03). CONCLUSIONS: In a large Japanese population, selected coping strategies were associated with all-cause mortality. The relationship of emotional support-seeking was different between men and women.

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  82. Differential effect of polymorphisms on body mass index across the life course of Japanese: the Japan Multi-Institutional Collaborative Cohort Study. Reviewed

    Madoka Iwase, Keitaro Matsuo, Masahiro Nakatochi, Isao Oze, Hidemi Ito, Yuriko Koyanagi, Tomotaka Ugai, Yumiko Kasugai, Asahi Hishida, Kenji Takeuchi, Rieko Okada, Yoko Kubo, Chisato Shimanoe, Keitaro Tanaka, Hiroaki Ikezaki, Masayuki Murata, Toshiro Takezaki, Daisaku Nishimoto, Nagato Kuriyama, Etsuko Ozaki, Sadao Suzuki, Miki Watanabe, Haruo Mikami, Yohko Nakamura, Hirokazu Uemura, Sakurako Katsuura-Kamano, Kiyonori Kuriki, Yoshikuni Kita, Takashima Naoyuki, Masato Nagino, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai

    Journal of epidemiology   Vol. 31 ( 3 ) page: 172 - 179   2021.3

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    BACKGROUND: Obesity is a reported risk factor for various health problems. Genome-wide association studies (GWASs) have identified numerous independent loci associated with body mass index (BMI). However, most of these have been focused on Europeans, and little evidence is available on the genetic effects across the life course of other ethnicities. METHODS: We conducted a cross-sectional study to examine the associations of 282 GWAS-identified single nucleotide polymorphisms with three BMI-related traits, current BMI, BMI at 20 years old (BMI at 20) and change in BMI (BMI change), among 11 586 Japanese individuals enrolled in the Japan Multi-Institutional Collaborative Cohort study. Associations were examined using multivariable linear regression models. RESULTS: We found a significant association (P < 0.05/282 = 1.77×10-4) between BMI and 11 polymorphisms in or near FTO, BDNF, TMEM18, HS6ST3, and BORCS7. The trend was similar between current BMI and BMI change, but differed from that of the BMI at 20. Among the significant variants, those on FTO were associated with all BMI traits, whereas those on TMEM18 and HS6SR3 were only associated with BMI at 20. The association of FTO loci with BMI remained even after additional adjustment for dietary energy intake. CONCLUSIONS: Previously reported BMI-associated loci discovered in Europeans were also identified in the Japanese population. Additionally, our results suggest that the effects of each loci on BMI may vary across the life course and that this variation may be caused by the differential effects of individual genes on BMI via different pathways.

    DOI: 10.2188/jea.JE20190296

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  83. Impact of PSCA polymorphisms on the risk of duodenal ulcer. Reviewed

    Yoshiaki Usui, Keitaro Matsuo, Isao Oze, Tomotaka Ugai, Yuriko Koyanagi, Yoshinobu Maeda, Hidemi Ito, Asahi Hishida, Kenji Takeuchi, Takashi Tamura, Mineko Tsukamoto, Yuka Kadomatsu, Megumi Hara, Yuichiro Nishida, Ippei Shimoshikiryo, Toshiro Takezaki, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Sadao Suzuki, Miki Watanabe, Hiroko Nakagawa-Senda, Haruo Mikami, Yohko Nakamura, Kokichi Arisawa, Hirokazu Uemura, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Hiroaki Ikezaki, Masayuki Murata, Masahiro Nakatochi, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai

    Journal of epidemiology   Vol. 31 ( 1 ) page: 12 - 20   2021.1

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    BACKGROUND: While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population. METHODS: PSCA six SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CI) for association between the SNPs and risk of DU/GU. RESULTS: PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18-1.51; P=2.28×10-6) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit and H. pylori status. On the other hand, we did not observe an association between the risk of GU and PSCA SNPs. CONCLUSIONS: Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.

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  84. ストレス対処行動とがん死亡リスクとの関係 J-MICC Study

    永吉 真子, 塚本 峰子, 久保 陽子, 岡田 理恵子, 田村 高志, 菱田 朝陽, 竹内 研時, 若井 建志

    Journal of Epidemiology   Vol. 31 ( Suppl. ) page: 115 - 115   2021.1

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  85. 精神的健康度とストレス対処行動との関連

    塚本 峰子, 久保 陽子, 永吉 真子, 岡田 理恵子, 篠壁 多恵, 川合 紗世, 田村 高志, 菱田 朝陽, 竹内 研時, 若井 建志

    Journal of Epidemiology   Vol. 31 ( Suppl. ) page: 122 - 122   2021.1

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  86. 炭水化物・脂質摂取量と全死亡との関連 日本多施設共同コーホート研究(J-MICC Study)

    田村 高志, 門松 由佳, 塚本 峰子, 久保 陽子, 岡田 理恵子, 永吉 真子, 菱田 朝陽, 竹内 研時, 若井 建志

    Journal of Epidemiology   Vol. 31 ( Suppl. ) page: 95 - 95   2021.1

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  87. Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study.

    Koyama T, Kuriyama N, Ozaki E, Tomida S, Uehara R, Nishida Y, Shimanoe C, Hishida A, Tamura T, Tsukamoto M, Kadomatsu Y, Oze I, Matsuo K, Mikami H, Nakamura Y, Ibusuki R, Takezaki T, Suzuki S, Nishiyama T, Kuriki K, Takashima N, Kadota A, Uemura H, Katsuura-Kamano S, Ikezaki H, Murata M, Takeuchi K, Wakai K, Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group.

    Journal of atherosclerosis and thrombosis   Vol. 27 ( 10 ) page: 1097 - 1107   2020.10

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    DOI: 10.5551/jat.54320

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  88. Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study.

    Takeuchi K, Naito M, Kawai S, Tsukamoto M, Kadomatsu Y, Kubo Y, Okada R, Nagayoshi M, Tamura T, Hishida A, Nakatochi M, Sasakabe T, Hashimoto S, Eguchi H, Momozawa Y, Ikezaki H, Murata M, Furusyo N, Tanaka K, Hara M, Nishida Y, Matsuo K, Ito H, Oze I, Mikami H, Nakamura Y, Kusakabe M, Takezaki T, Ibusuki R, Shimoshikiryo I, Suzuki S, Nishiyama T, Watanabe M, Koyama T, Ozaki E, Watanabe I, Kuriki K, Kita Y, Ueshima H, Matsui K, Arisawa K, Uemura H, Katsuura-Kamano S, Nakamura S, Narimatsu H, Hamajima N, Tanaka H, Wakai K

    Journal of epidemiology     2020.9

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  89. Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study. Reviewed International journal

    Kokichi Arisawa, Sakurako Katsuura-Kamano, Hirokazu Uemura, Nguyen Van Tien, Asahi Hishida, Takashi Tamura, Yoko Kubo, Mineko Tsukamoto, Keitaro Tanaka, Megumi Hara, Toshiro Takezaki, Daisaku Nishimoto, Teruhide Koyama, Etsuko Ozaki, Sadao Suzuki, Takeshi Nishiyama, Kiyonori Kuriki, Aya Kadota, Naoyuki Takashima, Hiroaki Ikezaki, Masayuki Murata, Isao Oze, Keitaro Matsuo, Haruo Mikami, Yohko Nakamura, Kenji Takeuchi, Kenji Wakai

    Nutrients   Vol. 12 ( 6 )   2020.5

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    The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35-69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12-1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns.

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  90. Subtype-specific gout susceptibility loci and enrichment of selection pressure on <i>ABCG2</i> and <i>ALDH2</i> identified by subtype genome-wide meta-analyses of clinically defined gout patients.

    Nakayama A, Nakatochi M, Kawamura Y, Yamamoto K, Nakaoka H, Shimizu S, Higashino T, Koyama T, Hishida A, Kuriki K, Watanabe M, Shimizu T, Ooyama K, Ooyama H, Nagase M, Hidaka Y, Matsui D, Tamura T, Nishiyama T, Shimanoe C, Katsuura-Kamano S, Takashima N, Shirai Y, Kawaguchi M, Takao M, Sugiyama R, Takada Y, Nakamura T, Nakashima H, Tsunoda M, Danjoh I, Hozawa A, Hosomichi K, Toyoda Y, Kubota Y, Takada T, Suzuki H, Stiburkova B, Major TJ, Merriman TR, Kuriyama N, Mikami H, Takezaki T, Matsuo K, Suzuki S, Hosoya T, Kamatani Y, Kubo M, Ichida K, Wakai K, Inoue I, Okada Y, Shinomiya N, Matsuo H, Japan Gout Genomics Consortium (Japan Gout).

    Annals of the rheumatic diseases   Vol. 79 ( 5 ) page: 657 - 665   2020.5

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  91. Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study. Reviewed

    Okada R, Kadomatsu Y, Tsukamoto M, Sasakabe T, Kawai S, Tamura T, Hishida A, Ikezaki H, Furusyo N, Tanaka K, Hara M, Suzuki S, Watanabe M, Takezaki T, Nishimoto D, Matsui D, Watanabe I, Kuriki K, Takashima N, Nakamura Y, Katsuura-Kamano S, Arisawa K, Mikami H, Nakamura Y, Oze I, Koyanagi YN, Naito M, Wakai K, Japan Multi-Institutional Collaborative Cohort, J-MICC) Study

    Journal of human hypertension   Vol. 34 ( 2 ) page: 125 - 131   2020.2

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  92. Associations between diet and mental health using the 12-item General Health Questionnaire: cross-sectional and prospective analyses from the Japan Multi-Institutional Collaborative Cohort Study. Reviewed International journal

    Naoki Choda, Kenji Wakai, Mariko Naito, Nahomi Imaeda, Chiho Goto, Kenta Maruyama, Yuka Kadomatsu, Mineko Tsukamoto, Tae Sasakabe, Yoko Kubo, Rieko Okada, Sayo Kawai, Takashi Tamura, Asahi Hishida, Kenji Takeuchi, Atsuyoshi Mori, Nobuyuki Hamajima

    Nutrition journal   Vol. 19 ( 1 ) page: 2 - 2   2020.1

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    BACKGROUND: Mental health has become a major public health issue worldwide. Biological and epidemiological studies suggest diet has a role in the prevention or cure of mental disorders. However, further research is required to elucidate the relationship between diet and mental health. This study aimed to investigate associations between dietary intake of nutrients (macronutrients, vitamins, calcium, and fatty acids) and food groups (fish, meat and chicken, dairy products, and vegetables) and mental health among middle-aged Japanese in cross-sectional and prospective studies. METHODS: In total, 9298 men and women that participated in two areas of the Japan Multi-Institutional Collaborative Cohort Study were eligible for analysis at the baseline (cross-sectional) survey. Of these, 4701 participants were followed for about 5 years and included in the follow-up (prospective) analysis. The 12-item General Health Questionnaire (GHQ) was used to assess participants' general mental health status over the past several weeks. The average intake of 46 foods over the past year was assessed by a validated food frequency questionnaire. We also evaluated lifestyle and medical factors using a self-administered questionnaire. A cross-sectional logistic regression analysis was performed to estimate odds ratios for a GHQ score ≥ 4 (poor mental health) according to dietary intake of foods/nutrients at baseline. The prospective study used baseline dietary and lifestyle factors and GHQ scores at follow-up. RESULTS: The cross-sectional logistic regression analysis showed vegetables, protein, calcium, vitamin D, carotene and n-3 highly-polyunsaturated fatty acids were inversely associated with a GHQ score ≥ 4. On the other hand, mono-unsaturated fatty acids showed a positive association with higher GHQ score. The prospective logistic regression analysis found dairy products, calcium, vitamin B2, and saturated fatty acids were inversely correlated with a GHQ score ≥ 4. Calcium was associated with GHQ scores in both the cross-sectional and follow-up studies. In the follow-up study, the multivariable-adjusted odds ratio for a GHQ score ≥ 4 was 0.71 (95% confidence interval, 0.55-0.92) for the highest versus lowest quartiles of calorie-adjusted dietary calcium intake. CONCLUSION: Consuming particular nutrients and foods, especially calcium and dairy products, may lead to better mental health in Japanese adults.

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  93. The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population.

    Nishida Y, Hachiya T, Hara M, Shimanoe C, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Tsukamoto M, Kadomatsu Y, Oze I, Koyanagi YN, Kuriyama N, Koyama T, Ibusuki R, Takezaki T, Ikezaki H, Furusyo N, Takashima N, Kadota A, Uemura H, Katsuura-Kamano S, Suzuki S, Nakagawa-Senda H, Kuriki K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K, Japan Multi-Institutional Collaborative Cohort Study Group.

    Journal of lipid research   Vol. 61 ( 1 ) page: 86 - 94   2020.1

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  94. A risk score predicting new incidence of hypertension in Japan. Reviewed

    Kadomatsu Y, Tsukamoto M, Sasakabe T, Kawai S, Naito M, Kubo Y, Okada R, Tamura T, Hishida A, Mori A, Hamajima N, Yokoi K, Wakai K

    Journal of human hypertension   Vol. 33 ( 10 ) page: 748 - 755   2019.10

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  95. Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. Reviewed International journal

    Yusuke Kawamura, Hirofumi Nakaoka, Akiyoshi Nakayama, Yukinori Okada, Ken Yamamoto, Toshihide Higashino, Masayuki Sakiyama, Toru Shimizu, Hiroshi Ooyama, Keiko Ooyama, Mitsuo Nagase, Yuji Hidaka, Yuko Shirahama, Kazuyoshi Hosomichi, Yuichiro Nishida, Ippei Shimoshikiryo, Asahi Hishida, Sakurako Katsuura-Kamano, Seiko Shimizu, Makoto Kawaguchi, Hirokazu Uemura, Rie Ibusuki, Megumi Hara, Mariko Naito, Mikiya Takao, Mayuko Nakajima, Satoko Iwasawa, Hiroshi Nakashima, Keizo Ohnaka, Takahiro Nakamura, Blanka Stiburkova, Tony R Merriman, Masahiro Nakatochi, Sahoko Ichihara, Mitsuhiro Yokota, Tappei Takada, Tatsuya Saitoh, Yoichiro Kamatani, Atsushi Takahashi, Kokichi Arisawa, Toshiro Takezaki, Keitaro Tanaka, Kenji Wakai, Michiaki Kubo, Tatsuo Hosoya, Kimiyoshi Ichida, Ituro Inoue, Nariyoshi Shinomiya, Hirotaka Matsuo

    Annals of the rheumatic diseases   Vol. 78 ( 10 ) page: 1430 - 1437   2019.10

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    OBJECTIVE: The first ever genome-wide association study (GWAS) of clinically defined gout cases and asymptomatic hyperuricaemia (AHUA) controls was performed to identify novel gout loci that aggravate AHUA into gout. METHODS: We carried out a GWAS of 945 clinically defined gout cases and 1003 AHUA controls followed by 2 replication studies. In total, 2860 gout cases and 3149 AHUA controls (all Japanese men) were analysed. We also compared the ORs for each locus in the present GWAS (gout vs AHUA) with those in the previous GWAS (gout vs normouricaemia). RESULTS: This new approach enabled us to identify two novel gout loci (rs7927466 of CNTN5 and rs9952962 of MIR302F) and one suggestive locus (rs12980365 of ZNF724) at the genome-wide significance level (p<5.0×10-8). The present study also identified the loci of ABCG2, ALDH2 and SLC2A9. One of them, rs671 of ALDH2, was identified as a gout locus by GWAS for the first time. Comparing ORs for each locus in the present versus the previous GWAS revealed three 'gout vs AHUA GWAS'-specific loci (CNTN5, MIR302F and ZNF724) to be clearly associated with mechanisms of gout development which distinctly differ from the known gout risk loci that basically elevate serum uric acid level. CONCLUSIONS: This meta-analysis is the first to reveal the loci associated with crystal-induced inflammation, the last step in gout development that aggravates AHUA into gout. Our findings should help to elucidate the molecular mechanisms of gout development and assist the prevention of gout attacks in high-risk AHUA individuals.

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  96. 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. Reviewed

    Takata R, Takahashi A, Fujita M, Momozawa Y, Saunders EJ, Yamada H, Maejima K, Nakano K, Nishida Y, Hishida A, Matsuo K, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Sasaki M, Shimizu A, Tanno K, Minegishi N, Suzuki K, Matsuda K, Kubo M, Inazawa J, Egawa S, Haiman CA, Ogawa O, Obara W, Kamatani Y, Akamatsu S, Nakagawa H

    Nature communications   Vol. 10 ( 1 ) page: 4422   2019.9

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  97. Polymorphisms in <i>CPT1B</i> and <i>CPT2</i> have no significant effect on plasma carnitine levels in Japanese cancer patients. Reviewed

    Hishida A, Watanabe R, Hattori Y, Okugawa Y, Shirai Y, Miki C

    Nagoya journal of medical science   Vol. 81 ( 3 ) page: 477 - 487   2019.8

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  98. GWAS analysis reveals a significant contribution of PSCA to the risk of Heliobacter pylori-induced gastric atrophy. Reviewed

    Hishida A, Ugai T, Fujii R, Nakatochi M, Wu MC, Ito H, Oze I, Tajika M, Niwa Y, Nishiyama T, Nakagawa-Senda H, Suzuki S, Koyama T, Matsui D, Watanabe Y, Kawaguchi T, Matsuda F, Momozawa Y, Kubo M, Naito M, Matsuo K, Wakai K

    Carcinogenesis   Vol. 40 ( 5 ) page: 661 - 668   2019.7

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  99. Association of genetic risk score and chronic kidney disease in a Japanese population. Reviewed

    Fujii R, Hishida A, Nakatochi M, Furusyo N, Murata M, Tanaka K, Shimanoe C, Suzuki S, Watanabe M, Kuriyama N, Koyama T, Takezaki T, Shimoshikiryo I, Arisawa K, Katsuura-Kamano S, Takashima N, Turin TC, Kuriki K, Endoh K, Mikami H, Nakamura Y, Oze I, Ito H, Kubo M, Momozawa Y, Kondo T, Naito M, Wakai K

    Nephrology (Carlton, Vic.)   Vol. 24 ( 6 ) page: 670 - 673   2019.6

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  100. CD36 gene polymorphism (rs1761667) is associated with dietary monounsaturated fatty acid intake and hypertension in a Japanese population. Reviewed

    Fujii R, Hishida A, Suzuki K, Imaeda N, Goto C, Hamajima N, Wakai K, Kondo T

    The British journal of nutrition   Vol. 121 ( 11 ) page: 1215 - 1222   2019.6

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  101. Associations of Nutrient Patterns with the Prevalence of Metabolic Syndrome: Results from the Baseline Data of the Japan Multi-Institutional Collaborative Cohort Study. Reviewed International journal

    Yuki Iwasaki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Hirokazu Uemura, Mineko Tsukamoto, Yuka Kadomatsu, Rieko Okada, Asahi Hishida, Keitaro Tanaka, Megumi Hara, Toshiro Takezaki, Keiichi Shimatani, Etsuko Ozaki, Teruhide Koyama, Sadao Suzuki, Hiroko Nakagawa-Senda, Kiyonori Kuriki, Naoko Miyagawa, Aya Kadota, Hiroaki Ikezaki, Norihiro Furusyo, Isao Oze, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Kenji Wakai

    Nutrients   Vol. 11 ( 5 )   2019.4

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    : The association between nutrient patterns and metabolic syndrome (MetS) has not been examined in a Japanese population. A cross-sectional study was performed on 30,108 participants (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Dietary intake was assessed using a 46-item food frequency questionnaire. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009, using body mass index instead of waist circumference. Factor analysis was applied to energy-adjusted intake of 21 nutrients, and three nutrient patterns were extracted: Factor 1 (fiber, potassium and vitamins pattern); Factor 2 (fats and fat-soluble vitamins pattern); and Factor 3 (saturated fatty acids, calcium and vitamin B2 pattern). In multiple logistic regression analysis adjusted for sex, age, and other potential confounders, Factor 1 scores were associated with a significantly reduced odds ratio (OR) of MetS and all five components. Factor 2 scores were associated with significantly increased prevalence of MetS, obesity, and high blood pressure. Factor 3 scores were significantly associated with lower OR of MetS, high blood pressure, high serum triglycerides and low HDL cholesterol levels. Analysis of nutrient patterns may be useful to assess the overall quality of diet and its association with MetS.

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  102. Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population. Reviewed

    Hirokazu Uemura, Sakurako Katsuura-Kamano, Yuki Iwasaki, Kokichi Arisawa, Asahi Hishida, Rieko Okada, Takashi Tamura, Yoko Kubo, Hidemi Ito, Isao Oze, Chisato Shimanoe, Yuichiro Nishida, Yasuyuki Nakamura, Naoyuki Takashima, Sadao Suzuki, Hiroko Nakagawa-Senda, Daisaku Nishimoto, Toshiro Takezaki, Haruo Mikami, Yohko Nakamura, Norihiro Furusyo, Hiroaki Ikezaki, Etsuko Ozaki, Teruhide Koyama, Kiyonori Kuriki, Kaori Endoh, Mariko Naito, Kenji Wakai

    Endocrine   Vol. 64 ( 3 ) page: 552 - 563   2019.4

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    Our results suggest that higher daily life activity and higher moderate-intensity exercise may be independently associated with a lower risk of metabolic syndrome in Japanese adults.

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  103. Coffee consumption and liver cancer risk in Japan: a meta-analysis of six prospective cohort studies

    Tamura Takashi, Hishida Asahi, Wakai Kenji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 1 ) page: 143 - 150   2019.2

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  104. Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care. Reviewed

    Hishida A, Okugawa Y, Morimoto Y, Shirai Y, Okamoto K, Momokita S, Ogawa A, Tanaka K, Nishikawa R, Toiyama Y, Inoue Y, Sakurai H, Urata H, Tanaka M, McMillan DC, Miki C

    Oncology letters   Vol. 17 ( 1 ) page: 623 - 629   2019.1

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    DOI: 10.3892/ol.2018.9614

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  105. 日本人121,745人を対象としたゲノムワイドメタ解析により血清尿酸値と関連する8つの新規遺伝子座を同定した

    中杤 昌弘, 松尾 洋孝, 中山 昌喜, 河村 優輔, 清水 聖子, 川口 真, 高尾 幹也, 四ノ宮 成祥, 金井 仁弘, 菱田 朝陽, 中村 好宏, 久保 充明, 鎌谷 洋一郎, 横田 充弘, 若井 建志, 岡田 随象

    日本痛風・核酸代謝学会総会プログラム抄録集   Vol. 52回   page: 75 - 75   2019.1

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  106. Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease: findings from the CKD-JAC study

    Nitta Kosaku, Iimuro Satoshi, Imai Enyu, Matsuo Seiichi, Makino Hirofumi, Akizawa Tadao, Watanabe Tsuyoshi, Ohashi Yasuo, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 23 ( 1 ) page: 85 - 98   2019.1

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  107. Risk factors for increased left ventricular hypertrophy in patients with chronic kidney disease: findings from the CKD-JAC study (vol 23, pg 85, 2018)

    Nitta Kosaku, Iimuro Satoshi, Imai Enyu, Matsuo Seiichi, Makino Hirofumi, Akizawa Tadao, Watanabe Tsuyoshi, Ohashi Yasuo, Hishida Akira

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   Vol. 23 ( 1 ) page: 99 - 99   2019.1

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  108. Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals. Reviewed

    Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Ichihara S, Akiyama M, Ikezaki H, Furusyo N, Shimizu S, Yamamoto K, Hirata M, Okada R, Kawai S, Kawaguchi M, Nishida Y, Shimanoe C, Ibusuki R, Takezaki T, Nakajima M, Takao M, Ozaki E, Matsui D, Nishiyama T, Suzuki S, Takashima N, Kita Y, Endoh K, Kuriki K, Uemura H, Arisawa K, Oze I, Matsuo K, Nakamura Y, Mikami H, Tamura T, Nakashima H, Nakamura T, Kato N, Matsuda K, Murakami Y, Matsubara T, Naito M, Kubo M, Kamatani Y, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H

    Communications biology   Vol. 2 ( 1 ) page: 115   2019

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    DOI: 10.1038/s42003-019-0339-0

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  109. The association between self-rated health and high-sensitivity C-reactive protein level: a cross-sectional and 5-year longitudinal study.

    Tamura T, Naito M, Maruyama K, Tsukamoto M, Sasakabe T, Okada R, Kawai S, Hishida A, Wakai K

    BMC public health   Vol. 18 ( 1 ) page: 1380   2018.12

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    DOI: 10.1186/s12889-018-6251-6

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  110. Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21. Reviewed

    Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, Momozawa Y, Hirata M, Fuse N, Takai-Igarashi T, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Hishida A, Wakai K, Furusyo N, Murakami Y, Nakamura Y, Imoto I, Inazawa J, Oze I, Sato N, Tanioka F, Sugimura H, Hirose H, Yoshida T, Matsuo K, Kubo M, Matsuda K

    Cancer science   Vol. 109 ( 12 ) page: 4015 - 4024   2018.12

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    DOI: 10.1111/cas.13815

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  111. The association of PSCA gene and H. pylori-related gastric atrophy risk detected by GWAS and SKAT

    Hishida Asahi, Fujii Ryosuke, Nakatochi Masahiro, Kawai Sayo, Ito Hidemi, Matsuo Keitaro, Watanabe Miki, Suzuki Sadao, Kuriyama Nagato, Naito Mariko, Wakai Kenji

    CANCER SCIENCE   Vol. 109   page: 774-774   2018.12

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  112. Genome-wide Association Study of Leisure-Time Exercise Behavior in Japanese Adults. Reviewed

    Hara M, Hachiya T, Sutoh Y, Matsuo K, Nishida Y, Shimanoe C, Tanaka K, Shimizu A, Ohnaka K, Kawaguchi T, Oze I, Matsuda F, Ito H, Kawai S, Hishida A, Okada R, Sasakabe T, Hirata A, Ibusuki R, Nindita Y, Furusyo N, Ikezaki H, Kuriyama N, Ozaki E, Mikami H, Nakamura Y, Suzuki S, Hosono A, Katsuura-Kamano S, Arisawa K, Kuriki K, Endoh K, Takashima N, Kadota A, Nakatochi M, Momozawa Y, Kubo M, Naito M, Wakai K

    Medicine and science in sports and exercise   Vol. 50 ( 12 ) page: 2433 - 2441   2018.12

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    DOI: 10.1249/MSS.0000000000001712

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  113. The association of PSCA gene and H. pylori-related gastric atrophy risk detected by GWAS and SKAT Reviewed

    Hishida Asahi, Fujii Ryosuke, Nakatochi Masahiro, Kawai Sayo, Ito Hidemi, Matsuo Keitaro, Watanabe Miki, Suzuki Sadao, Kuriyama Nagato, Naito Mariko, Wakai Kenji

    CANCER SCIENCE   Vol. 109   page: 774   2018.12

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  114. 日本人における尿酸値のGWASメタ解析による8個の新規遺伝子座の同定

    中嶌 真由子, 中杤 昌弘, 金井 仁弘, 中山 昌喜, 菱田 朝陽, 河村 優輔, 青柳 有香, 久保 充明, 鎌谷 洋一郎, 横田 充弘, 若井 建志, 岡田 随象, 四ノ宮 成祥, 松尾 洋孝

    防衛衛生   Vol. 66 ( 別冊 ) page: 44 - 44   2018.12

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  115. Polymorphisms in folic acid metabolism genes do not associate with cancer cachexia in Japanese gastrointestinal patients. Reviewed

    Morishita T, Hishida A, Okugawa Y, Morimoto Y, Shirai Y, Okamoto K, Momokita S, Ogawa A, Tanaka K, Nishikawa R, Toiyama Y, Inoue Y, Sakurai H, Urata H, Tanaka M, Miki C

    Nagoya journal of medical science   Vol. 80 ( 4 ) page: 529 - 539   2018.11

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  116. Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study. Reviewed

    Tamura T, Kadomatsu Y, Tsukamoto M, Okada R, Sasakabe T, Kawai S, Hishida A, Hara M, Tanaka K, Shimoshikiryo I, Takezaki T, Watanabe I, Matsui D, Nishiyama T, Suzuki S, Endoh K, Kuriki K, Kita Y, Katsuura-Kamano S, Arisawa K, Ikezaki H, Furusyo N, Koyanagi YN, Oze I, Nakamura Y, Mikami H, Naito M, Wakai K, Japan Multi-Institutional Collaborative Cohort, J-MICC) Study

    Medicine   Vol. 97 ( 48 ) page: e13241   2018.11

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  117. WEIGHT GAIN IN ADULTHOOD AND PARENTAL HYPERTENSION AS THE RISK OF HYPERTENSION: FROM THE J-MICC STUDY Reviewed

    JOURNAL OF HYPERTENSION   Vol. 36   page: E320   2018.10

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  118. Clinical burden of modified glasgow prognostic scale in colorectal cancer Reviewed

    Yoshinaga Okugawa, Yumiko Shirai, Yuji Toiyama, Susumu Saigusa, Asahi Hishida, Takeshi Yokoe, Koji Tanaka, Motoyoshi Tanaka, Hiromi Yasuda, Hiroyuki Fujikawa, Junichiro Hiro, Minako Kobayashi, Toshimitsu Araki, Yasuhiro Inoue, Donald C. McMillan, Masato Kusunoki, Chikao Miki

    Anticancer Research   Vol. 38 ( 3 ) page: 1599 - 1610   2018.3

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    Background/Aim: This study aimed to clarify the potential of modified Glasgow Prognostic Score (mGPS) as a prognostic biomarker and reveal the significance of fish oil (FO)-enriched nutrition in colorectal cancer (CRC). Patients and Methods: A total of 738 CRC patients from three different patient cohorts, including 670 patients in the biomarker study and 68 patients in the nutrition-intervention study, were analyzed. Results: High preoperative mGPS was significantly correlated with well-recognized disease progression factors and advanced UICC stage classification. In addition, high mGPS was an independent prognostic factor in both cohorts, especially in stage III and IV patients. These statuses were maintained in postoperative course and correlated with sarcopenia. Furthermore, FO-enriched nutrition suppressed systemic inflammatory reaction and improved skeletal muscle mass and prognosis, especially in CRC patients with mGPS 1 or 2. Conclusion: Assessment of mGPS could identify patients with high-risk CRC, who might be candidates for FO-enriched nutrition.

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  119. Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population Reviewed

    Seiki T, Naito M, Hishida A, Takagi S, Matsunaga T, Sasakabe T, Hattori Y, Kawai S, Okada R, Yin G, Hamajima N, Wakai K

    Gene   Vol. 642   page: 172-177   2018.2

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    DOI: 10.1016/j.gene.2017.11.031

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  120. A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study Reviewed

    Nakagawa-Senda H, Hachiya T, Shimizu A, Hosono S, Oze I, Watanabe M, Matsuo K, Ito H, Hara M, Nishida Y, Endoh K, Kuriki K, Katsuura-Kamano S, Arisawa K, Nindita Y, Ibusuki R, Suzuki S, Hosono A, Mikami H, Nakamura Y, Takashima N, Nakamura Y, Kuriyama N, Ozaki E, Furusyo N, Ikezaki H, Nakatochi M, Sasakabe T, Kawai S, Okada R, Hishida A, Naito M, Wakai K, Momozawa Y, Kubo M, Tanaka H

    Sci Rep   Vol. 8 ( 1 ) page: 1493   2018.1

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  121. A common variant of MAF/c-MAF, transcriptional factor gene in the kidney, is associated with gout susceptibility Reviewed

    Toshihide Higashino, Hirotaka Matsuo, Yukinori Okada, Hiroshi Nakashima, Seiko Shimizu, Masayuki Sakiyama, Shin Tadokoro, Akiyoshi Nakayama, Makoto Kawaguchi, Mako Komatsu, Asahi Hishida, Masahiro Nakatochi, Hiroshi Ooyama, Junko Imaki, Nariyoshi Shinomiya

    Human Cell   Vol. 31 ( 1 ) page: 10 - 13   2018.1

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    Gout is a multifactorial disease characterized by acute inflammatory arthritis, and it is caused as a consequence of hyperuricemia. A recent meta-analysis of genome-wide association studies has newly identified the relationship between serum uric acid (SUA) levels and rs889472, a single nucleotide polymorphism of musculoaponeurotic fibrosarcoma oncogene (MAF/c-MAF). However, it remained unclear whether rs889472 is associated with gout susceptibility. In the present study, we investigate the association between c-MAF rs889472 and gout in Japanese male population. We genotyped 625 male patients who were clinically diagnosed as gout and 1221 male control subjects without hyperuricemia or a history of gout by TaqMan method. As a result, the major allele (C), which reportedly increases SUA levels, had a higher frequency in the gout cases (58.8%) than in the controls (55.0%). A logistic regression analysis showed a significant association between rs889472 and gout (p = 0.029, odds ratio = 1.17
    95% confidence interval 1.02–1.34). C-MAF is reported as a pivotal transcriptional factor in the development and differentiation of renal proximal tubular cells. Because urate is mainly regulated in renal proximal tubular cells, c-MAF may have an important role in urate regulation in the kidney and influence not only SUA but also gout susceptibility. Our finding shows that rs889472 of c-MAF is associated with gout susceptibility.

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  122. Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglycerides by ALDH2 and ADH1B polymorphisms in Japanese men Reviewed

    Sasakabe T, Wakai K, Kawai S, Hishida A, Naito M, Suzuki S, Nindita Y, Arisawa K, Kita Y, Hara M, Kuriyama N, Hirata A, Mikami H, Oze I, Kubo M, Tanaka H, Hamajima N

    J Epidemiol   Vol. in press   2018

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    DOI: 10.2188/jea.JE20160189

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  123. Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1. Reviewed

    Yodsurang V, Tang Y, Takahashi Y, Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Fuse N, Sugawara J, Shimizu A, Fukushima A, Hishida A, Furusyo N, Naito M, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Hirata M, Murakami Y, Kubo M, Matsuda K

    PloS one   Vol. 13 ( 12 ) page: e0209096   2018

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  124. A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression

    Shimanoe C, Hachiya T, Hara M, Nishida Y, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Kawai S, Okada R, Tamura T, Matsuo K, Ito H, Ozaki E, Matsui D, Ibusuki R, Shimoshikiryo I, Takashima N, Kadota A, Arisawa K, Uemura H, Suzuki S, Watanabe M, Kuriki K, Endoh K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K

    Genes Brain Behav   Vol. 18 ( 2 ) page: e12481   2018

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    Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met sugg

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  125. Genetic variants of RAMP2 and CLR are associated with stroke Reviewed

    Koyama T, Kuriyama N, Ozaki E, Matsui D, Watanabe I, Takeshita W, Iwai K, Watanabe Y, Nakatochi M, Shimanoe C, Tanaka K, Oze I, Ito H, Uemura H, Katsuura-Kamano S, Ibusuki R, Shimoshikiryo I, Takashima N, Kadota A, Kawai S, Sasakabe T, Okada R, Hishida A, Naito M, Kuriki K, Endoh K, Furusyo N, Ikezaki H, Suzuki S, Hosono A, Mikami H, Nakamura Y, Kubo M, Wakai K

    J Atheroscler Thromb   Vol. 24 ( 12 ) page: 1267-1281   2017.12

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  126. A panel of methylated microRNA biomarkers for identifying high-risk patients with ulcerative colitis-associated colorectal cancer Reviewed

    Toiyama Y, Okugawa Y, Tanaka K, Araki T, Uchida K, Hishida A, Uchino M, Ikeuchi H, Hirota S, Kusunoki M, Boland C R, Goel A

    Gastroenterology   Vol. 153 ( 6 ) page: 1634-1646   2017.12

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  127. Real-world experience of anti-tumor necrosis factor therapy for internal fistulas in crohn's disease: a retrospective multicenter cohort study Reviewed

    Kobayashi T, Hishida A, Tanaka H, Nuki Y, Bamba S, Yamada A, Fujii T, Shinzaki S, Yokoyama Y, Yoshida A, Ozeki K, Ashizuka S, Kamata N, Nanjo S, Kakimoto K, Nakamura M, Matsui A, Yamauchi R, Takahashi S, Tomizawa T, Yoshino T, Hibi T

    Inflamm Bowel Dis   Vol. 23 ( 12 ) page: 2245-2251   2017.12

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  128. Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia Reviewed

    Shirai Y, Okugawa Y, Hishida A, Ogawa A, Okamoto K, Shintani M, Morimoto Y, Nishikawa R, Yokoe T, Tanaka K, Urata H, Toiyama Y, Inoue Y, Tanaka M, Mohri Y, Goel A, Kusunoki M, McMillan D C, Miki C

    Sci Rep   Vol. 7 ( 1 ) page: 4826   2017.7

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    DOI: 10.1038/s41598-017-05278-0

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  129. URAT1/SLC22A12遺伝子の機能消失型変異が血清尿酸値および痛風・高尿酸血症の発症に与える影響

    崎山 真幸, 松尾 洋孝, 清水 聖子, 中山 昌喜, 東野 俊英, 高田 龍平, 市田 公美, 大山 博司, 清水 徹, 四ノ宮 成祥, 中村 好宏, 内藤 真理子, 須磨 紫乃, 菱田 朝陽

    痛風と核酸代謝   Vol. 41 ( 1 ) page: 143 - 143   2017.7

  130. Objective predictive score as a feasible biomarker for short-term survival in terminalIy Ill patients with cancer Reviewed

    Okugawa Y, Shirai Y, Nodono H, Matsutani F, Itoh M, Hishida A, Morimoto Y, Nishikawa R, Yokoe T, Tanaka K, Urata H, Toiyama Y, Araki T, Inoue Y, Tanaka M, Kusunoki M, Miki C

    Anticancer Res   Vol. 37 ( 1 ) page: 267-275   2017.1

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  131. Metallothionein MT2A A-5G Polymorphism and the Risk for Chronic Kidney Disease and Diabetes Reviewed

    Yuta Hattori, Mariko Naito, Masahiko Satoh, Masahiro Nakatochi, Hisao Naito, Masashi Kato, Sahoko Takagi, Takashi Matsunaga, Toshio Seiki, Tae Sasakabe, Shino Suma, Sayo Kawai, Rieko Okada, Asahi Hishida, Nobuyuki Hamajima, Kenji Wakai

    TOXICOLOGICAL SCIENCES   Vol. 154 ( 2 ) page: 198 - 199   2016.12

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  132. 大腸 免疫療法の進化 消化器がん患者に対する免疫栄養療法の有用性の検討

    白井 由美子, 奥川 喜永, 菱田 朝陽, 新谷 実希, 小川 亜希, 福迫 朝子, 岡本 京子, 小澤 一夫, 福森 和俊, 田中 光司, 田中 基幹, 三木 誓雄

    日本癌治療学会学術集会抄録集   Vol. 54回   page: MS62 - 4   2016.10

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  133. 大腸癌におけるmGPSのpatient selection markerとしての有用性と、体組成計を用いたEPA栄養療法の有効性

    奥川 喜永, 問山 裕二, 田中 光司, 白井 由美子, 菱田 朝陽, 小川 亜希, 小澤 一夫, 森本 雄貴, 西川 隆太郎, 濱口 哲也, 浦田 久志, 田中 基幹, 藤川 裕之, 廣 純一郎, 井上 靖浩, 毛利 靖彦, 三木 誓雄, 楠 正人

    日本大腸肛門病学会雑誌   Vol. 69 ( 抄録号 ) page: A152 - A152   2016.10

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  134. The effects of URAT1/SLC22A12 nonfunctional variants,R90H and W258X, on serum uric acid levels and gout/hyperuricemia progression Reviewed

    Sakiyama M, Matsuo H, Shimizu S, Nakashima H, Nakamura T, Nakayama A, Higashino T, Naito M, Suma S, Hishida A, Satoh T, Sakurai Y, Takada T, Ichida K, Ooyama H, Shimizu T, Shinomiya N

    Sci Rep   Vol. 6   page: 20148   2016.1

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  135. Effects of IL6 C-634G polymorphism on tooth loss and their interaction with smoking habits Reviewed

    S. Suma, M. Naito, K. Wakai, T. Sasakabe, Y. Hattori, R. Okada, S. Kawai, A. Hishida, E. Morita, H. Nakagawa, T. Tamura, N. Hamajima

    ORAL DISEASES   Vol. 21 ( 6 ) page: 807 - 813   2015.9

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    ObjectiveTo examine the association between an IL6 (Interleukin-6) polymorphism (C-634G or rs1800796) and tooth loss, and an interaction between the polymorphism and smoking habits for the loss.
    Material and MethodsOur subjects were 4917 check-up examinees ages 35-69. They reported tooth loss and lifestyle in a questionnaire. We regressed the number of teeth on the IL6 genotype, gender, age, smoking, drinking, diabetes, hypertension, physical activity, energy intake, education, and brushing. We further estimated multivariate-adjusted odds ratios (ORs) for having &lt;20 teeth.
    ResultsParticipants with a GG genotype tended to have less teeth than those with CC; =-0.798 (95% confidence interval [CI]=-1.501--0.096). Subjects with a GG genotype were more likely to have &lt;20 teeth than those with CC; OR was 1.56 (95% CI=1.08-2.25). Association between current smoking and tooth loss was stronger among those with GG than among those with CC. In a multiple regression analysis, a significant interaction was found between GG genotype and current smoking in the prediction of tooth loss (P=0.018).
    ConclusionThe IL6 C-634G polymorphism was significantly associated with tooth loss. Our results suggest greater effects of smoking on tooth loss in GG genotype individuals.

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    Other Link: http://orcid.org/0000-0002-4867-0201

  136. GGT1 intronic A>G polymorphism affects serum concentration of γ-glutamyltransferase among Japanese healthy adult. Reviewed

    Kawai S, Naito M, Morita E, Okada R, Hishida A, Wakai K, Hamajima N

    Ningen Dock International   Vol. 2 ( 2 ) page: 7 - 11   2015.3

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  137. Tumor intrinsic subtype is reflected in cancer-adjacent tissue Reviewed

    Casbas-Hernandez P, Sun X, Roman-Perez E, D'Arcy M, Sandhu R, Hishida A, McNaughton K K, Yang X i R, Makowski L, Sherman M E, Figueroa J D, Troester M A.

    Cancer Epidemiol Biomarkers Prev   Vol. 24 ( 2 ) page: 406-414   2015.2

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  138. No association between Helicobacter pylori infection and diabetes mellitus among a general Japanese population: a cross-sectional study Reviewed

    Takashi Tamura, Emi Morita, Sayo Kawai, Tae Sasakabe, Yuka Sugimoto, Nana Fukuda, Shino Suma, Hiroko Nakagawa, Rieko Okada, Asahi Hishida, Mariko Naito, Nobuyuki Hamajima, Kenji Wakai

    SPRINGERPLUS   Vol. 4 ( 1 ) page: 602   2015

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    Several case-control studies have reported that patients with diabetes mellitus (DM) had a higher prevalence of Helicobacter pylori infection than those without DM, but these findings remain equivocal. Additionally, there are few studies examining associations between East Asian CagA-positive H. pylori and DM. This cross-sectional study aimed to investigate whether H. pylori infection was a possible risk factor for DM in a general Japanese population. The study included 5165 subjects (1467 men, 3698 women) aged 35-69 years from the Daiko Study, part of the Japan Multi-Institutional Collaborative Cohort Study. A urinary anti-H. pylori antibody was used to detect H. pylori infection. The medical history of physician-diagnosed DM was confirmed by self-administered questionnaire. The odds ratios (ORs) and their 95 % confidence intervals (CIs) for DM (current and former) were calculated using unconditional logistic regression analysis, adjusting for age, sex, educational status, alcohol use, smoking status, body mass index, energy intake, and physical activity. The prevalence of DM was 4.6 % (95 % CI 3.7-5.6 %) among 1878 participants with H. pylori infection and 3.2 % (2.6-3.8 %) among 3287 without the infection (p = 0.009). The crude, age-adjusted, and multivariate-adjusted ORs for DM in those with the infection relative to those without were 1.47 (95 % CI 1.10-1.97), 1.02 (0.76-1.38), and 0.97 (0.71-1.32), respectively. We found a significantly higher DM prevalence among those with H. pylori infection than among those without. However, almost all the difference in prevalence could be explained by the older age of those infected. Our findings did not support an association between H. pylori infection and DM.

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  139. GGT1 intronic A>G polymorphism affects setum concentration of γ-glutamyl transpeptidase among Japanese healthy adults Reviewed

    Kawai S, Naito M, Morita E, Okada R, Hishida A, Wakai K, Hamajima N.

    Ningen Dock International   Vol. 2 ( 2 ) page: 65-69   2015

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  140. GGT1 intronic A>G polymorphism affects setum concentration of gammma-glutamyl transpeptidase among Japanese healthy adults.

    Kawai S, Naito M, Morita E, Okada R, Hishida A, Wakai K, Hamajima N

    Ningen Dock International   Vol. 2   page: 65 - 69   2015

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  141. Common Variant of PDZK1, Adaptor Protein Gene of Urate Transporters, is Not Associated with Gout Reviewed

    Yuzo Takada, Hirotaka Matsuo, Akiyoshi Nakayama, Masayuki Sakiyama, Asahi Hishida, Rieko Okada, Yutaka Sakurai, Toru Shimizu, Kimiyoshi Ichida, Nariyoshi Shinomiya

    JOURNAL OF RHEUMATOLOGY   Vol. 41 ( 11 ) page: 2330 - 1   2014.11

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  142. Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study Reviewed

    Asahi Hishida, Kenji Wakai, Mariko Naito, Shino Suma, Tae Sasakabe, Nobuyuki Hamajima, Satoyo Hosono, Mikako Horita, Tanvir Chowdhury Turin, Sadao Suzuki, Tara Sefanya Kairupan, Haruo Mikami, Keizo Ohnaka, Isao Watanabe, Hirokazu Uemura, Michiaki Kubo, Hideo Tanaka

    LIPIDS IN HEALTH AND DISEASE   Vol. 13 ( 1 ) page: 162   2014.10

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    Background: Chronic kidney disease (CKD) is known to be one of the causes of cardiovascular disease and end-stage renal disease. Among the several treatable risk factors of CKD, that of dyslipidemia is relatively controversial. To clarify the association of polymorphisms in genes involved in lipid metabolism with the risk of CKD in the Japanese population, we used cross-sectional data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.
    Methods: A total of 3,268 men and women, aged 35-69 years, were selected from J-MICC Study participants for inclusion in this study. Twenty-eight candidate single nucleotide polymorphisms (SNPs) were selected in 17 genes associated with the risk of lipid metabolism disorders, and genotyping of the subjects was conducted using the multiplex PCR-based invader assay. The prevalence of CKD was determined for stages 3-5 (defined as estimated glomerular filtration rate &lt;60 ml/min/1.73 m(2)).
    Results: Logistic regression analysis revealed that SNPs APOA5 T -1131C (rs662799), APOA5 T1259C (rs2266788), TOMM40 A/G (rs157580), and CETP TaqIB (rs708272) were significantly associated with CKD risk in those individuals genotyped, with age-and sex-adjusted odds ratios (ORs) per minor allele (and 95% confidence intervals (CIs)) of OR 1.22 (95% CI: 1.06-1.39), 1.19 (1.03-1.37), 1.27 (1.12-1.45), and 0.81 (0.71-0.92), respectively. Analysis of the gene-environment interaction revealed that body mass index (BMI) was a significant effect modifier for APOA5 T -1131C (rs662799) and a marginally significant effect modifier for APOA5 T/C (rs2266788), with the interaction between BMI &gt;= 30 and individuals with at least one minor allele of each genotype of OR 10.43 (95% CI: 1.29-84.19) and 3.36 (0.87-13.01), respectively.
    Conclusions: Four polymorphisms in APOA5, TOMM40, and CETP were shown to be significantly associated with CKD risk, and a significant interaction between the two APOA5 SNPs and BMI on CKD risk was also demonstrated. This suggests the future possibility of personalized risk estimation for this life-limiting disease.

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  143. Associations Between hOGG1 Ser326Cys Polymorphism and Increased Body Mass Index and Fasting Glucose Level in the Japanese General Population Reviewed

    Megumi Hara, Kazuyo Nakamura, Hinako Nanri, Yuichiro Nishida, Asahi Hishida, Sayo Kawai, Nobuyuki Hamajima, Yoshikuni Kita, Sadao Suzuki, Eva Mariane Mantjoro, Keizo Ohnaka, Hirokazu Uemura, Daisuke Matsui, Isao Oze, Haruo Mikami, Michiaki Kubo, Hideo Tanaka

    JOURNAL OF EPIDEMIOLOGY   Vol. 24 ( 5 ) page: 379 - 84   2014

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    Background: Evidence suggests that Ser326Cys, a genetic polymorphism of human 8-oxoguanine glycosylase 1 (hOGG1), is associated with insulin resistance and type 2 diabetes; however, the underlying mechanism is unclear. Recently, an animal study showed a significant association between the hOGG1 genotype and obesity, although evidence for such an association in humans is limited. The purpose of this study was to examine the association between the hOGG1 genotype and body mass index (BMI) and fasting blood glucose (FBG) levels.
    Methods: Cross-sectional analysis was conducted using the baseline survey data from a Japan Multi-Institutional Collaborative Cohort Study, which included 1793 participants aged 40-69 years. The hOGG1 polymorphism was detected using a multiplex polymerase chain reaction-based invader assay. Multiple linear regression, analysis of covariance, and logistic regression were used to control for confounding variables.
    Results: The Cys allele was significantly associated with increased BMI, FBG level, and total cholesterol (TC) level, even after adjustment for gender, age, energy intake, alcohol, smoking, physical activity, and family history of diabetes. An association with BMI was still observed after further adjustment for FBG and TC, but not for the study area (Amami or the mainland). The Cys/Cys genotype was significantly more prevalent in the participants with higher BMI (&gt;27.5 kg/m(2)). However, the impact of genotype decreased and significance disappeared after adjusting for the study area.
    Conclusions: The present results suggest that the study area being inside Japan confounds the association between hOGG1 genotype and obesity.

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  144. A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility Reviewed

    Nakayama Akiyoshi, Matsuo Hirotaka, Shimizu Takuya, Ogata Hiraku, Takada Yuzo, Nakashima Hiroshi, Nakamura Takahiro, Shimizu Seiko, Chiba Toshinori, Sakiyama Masayuki, Ushiyama Chisaki, Takada Tappei, Inoue Katsuhisa, Kawai Sayo, Hishida Asahi, Wakai Kenji, Hamajima Nobuyuki, Ichida Kimiyoshi, Sakurai Yutaka, Kato Yukio, Shimizu Toru, Shinomiya Nariyoshi

    HUMAN CELL   Vol. 26 ( 4 ) page: 133 - 136   2013.12

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  145. Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study Reviewed

    Asahi Hishida, Rieko Okada, Mariko Naito, Emi Morita, Kenji Wakai, Nobuyuki Hamajima, Satoyo Hosono, Hinako Nanri, Tanvir Chowdhury Turin, Sadao Suzuki, Kazuyo Kuwabara, Haruo Mikami, Sanjeev Budhathoki, Isao Watanabe, Kokichi Arisawa, Michiaki Kubo, Hideo Tanaka

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 53 ( 1 ) page: 15 - 20   2013.7

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    Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) with the risk of CKD in Japanese, we examined this association using the cross-sectional data of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The subjects were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants for whom genotyping were conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (eGFR &lt;60 ml/min/1.73 m(2)). When those with CAT C-262T C/C were defined as reference, those with CAT C-262T C/T demonstrated the OR for CKD of 0.67 (95% Cl 0.43-1.06) with the marginally significant trend for decreased odds ratio with increasing numbers of T allele (p = 0.070). There were no significant associations between the other polymorphisms with CKD risk. The present study found a marginally significant trend of the decreased risk of CKD with increasing numbers of T allele of CAT, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.

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  146. MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study. Reviewed

    Asahi Hishida, Rieko Okada, Yin Guang, Mariko Naito, Kenji Wakai, Satoyo Hosono, Kazuyo Nakamura, Chowdhury Tanvir Turin, Sadao Suzuki, Hideshi Niimura, Haruo Mikami, Jun Otonari, Nagato Kuriyama, Sakurako Katsuura, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima

    International Urology and Nephrology   Vol. 45 ( 6 ) page: 1613 - 20   2013.4

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    PURPOSE: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the associations of MTHFR, MTR, and MTRR polymorphisms with the risk of CKD in Japanese, we examined this association among Japanese subjects using cross-sectional data. METHODS: The subjects for this analysis were 3,318 participants consecutively selected from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. The polymorphisms were genotyped by a multiplex polymerase chain reaction-based Invader assay. Age- and sex-adjusted odds ratio (aOR) of CKD with stage 3-5 was calculated for each genotype. RESULTS: When those with MTHFR C677T C/C were defined as references, those with MTHFR C677T C/T and T/T demonstrated the aORs for CKD of 1.14 (95 % CI 0.93-1.40) and 1.39 (1.06-1.82), respectively. Marginally significantly decreased risk of CKD with increasing number of MTR A2756G G allele (p = 0.058) was observed. Stratified analyses by plasma folate low (&lt;7.4 ng/ml) or high (?7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. CONCLUSIONS: The present study found a significant association between the subjects with the T/T genotype of MTHFR C677T polymorphism and the elevated risk of CKD, which may suggest the possibility of the risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.

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  147. Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of Type 2 DM in Japanese - the J-MICC Study [Rapid Communication] Reviewed

    Hishida A, Wakai K, Okada R, Morita E, Hamajima N, Hosono S, Higaki Y, Chowdhury Turin T, Suzuki S, Motahareh K, Mikami H, Tashiro N, Watanabe I, Katsuura S, Kubo M, Tanaka H, Naito M.

    Endocr J   Vol. 60 ( 2 ) page: 237-243   2013.2

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  148. Polymorphisms in PPAR genes (PPARD, PPARG, and PPARGC1A) and the risk of chronic kidney disease in Japanese: Cross-sectional data from the J-MICC study Reviewed

    Asahi Hishida, Kenji Wakai, Mariko Naito, Takashi Tamura, Sayo Kawai, Nobuyuki Hamajima, Isao Oze, Takeshi Imaizumi, Tanvir Chowdhury Turin, Sadao Suzuki, Motahare Kheradmand, Haruo Mikami, Keizo Ohnaka, Yoshiyuki Watanabe, Kokichi Arisawa, Michiaki Kubo, Hideo Tanaka

    PPAR Research   Vol. 2013   page: 980471   2013

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    Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross-sectional data of J-MICC (Japan Multi-Institutional Collaborative Cohort) Study. The subjects for this analysis were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants
    genotyping was conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (defined as eGFR &lt
    60 ml/min/1.73 m2). Participants with CKD accounted for 17.3% of the study population. When those with PPARD T-842C T/T were defined as reference, those with PPARD T-842C T/C and C/C demonstrated the OR for CKD of 1.26 (95%CI 1.04-1.53) and 1.31 (95%CI 0.83-2.06), respectively. There were no significant associations between the polymorphisms in other PPAR genes and the risk of CKD. The present study found a significantly increased risk of CKD in those with the C allele of PPARD T-842C, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future. © 2013 Asahi Hishida et al.

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  149. Common dysfunctional variants in ABCG2 are a major cause of early-onset gout Reviewed

    Hirotaka Matsuo, Kimiyoshi Ichida, Tappei Takada, Akiyoshi Nakayama, Hiroshi Nakashima, Takahiro Nakamura, Yusuke Kawamura, Yuzo Takada, Ken Yamamoto, Hiroki Inoue, Yuji Oikawa, Mariko Naito, Asahi Hishida, Kenji Wakai, Chisa Okada, Seiko Shimizu, Masayuki Sakiyama, Toshinori Chiba, Hiraku Ogata, Kazuki Niwa, Makoto Hosoyamada, Atsuyoshi Mori, Nobuyuki Hamajima, Hiroshi Suzuki, Yoshikatsu Kanai, Yutaka Sakurai, Tatsuo Hosoya, Toru Shimizu, Nariyoshi Shinomiya

    Scientific Reports   Vol. 3   page: 2014   2013

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    Gout is a common disease which mostly occurs after middle age, but more people nowadays develop it before the age of thirty. We investigated whether common dysfunction of ABCG2, a high-capacity urate transporter which regulates serum uric acid levels, causes early-onset gout. 705 Japanese male gout cases with onset age data and 1,887 male controls were genotyped, and the ABCG2 functions which are estimated by its genotype combination were determined. The onset age was 6.5â.years earlier with severe ABCG2 dysfunction than with normal ABCG2 function (P = 6.14 × 10-3). Patients with mild to severe ABCG2 dysfunction accounted for 88.2% of early-onset cases (twenties or younger). Severe ABCG2 dysfunction particularly increased the risk of early-onset gout (odds ratio 22.2, P = 4.66 × 10-6). Our finding that common dysfunction of ABCG2 is a major cause of early-onset gout will serve to improve earlier prevention and therapy for high-risk individuals.

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  150. Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity Reviewed

    Mineyoshi Hiyoshi, Hirokazu Uemura, Kokichi Arisawa, Mariko Nakamoto, Asahi Hishida, Rieko Okada, Keitaro Matsuo, Yoshikuni Kita, Hideshi Niimura, Nagato Kuriyama, Hinako Nanri, Keizo Ohnaka, Sadao Suzuki, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima

    GENE   Vol. 496 ( 2 ) page: 97 - 102   2012.4

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    In our previous proteomic study in rat liver damaged by carbon tetrachloride, soluble catechol-O-methyltransferase (COMT) increased as a phosphorylated form and decreased as a dephosphorylated form. This finding raised the possibility that the COMT protein is associated with liver function. Thus, we hypothesized that (1) the COMT gene contributes to liver homeostasis and (2) a COMT polymorphism (rs4680: Val158Met) causing thermolability of enzymatic activity affects liver enzymes (e.g., aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (gamma-GT)) in serum. To investigate (2), we statistically analyzed the association between COMT genotypes and serum ALT activity in a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We conducted a multiple logistic regression analysis for males (n = 838) and females (n = 970). Those participants having missing values or a past history of liver cirrhosis or liver cancer were excluded. ALT values were divided into two; elevated (30 IU/L &lt;=; males n = 239, females n = 90) and normal (&lt;30 IU/L; males n = 599, females n = 880). In females, non-adjusted and adjusted odds ratios for ALT values in the rs4680 A/A homozygote (n = 126) compared with the wild-type G/G homozygote (n = 397) were 0.37 (95% CI 0.14-0.96) and 034 (95% CI 0.13-0.93), respectively. In males, an analysis of the population aged 35-69 did not reveal any significant difference, but the population aged 45-54 had a significant difference in the non-adjusted and adjusted odds ratio in the G/A heterozygote (n = 89) (0.50 (95% CI 0.27-0.92) and 0.35 (95% CI 0.18-0.71)) and in the A/A homozygote (n = 22) (0.34 (95% CI 0.11-0.99) and 0.22 (95% CI 0.07-0.72)), compared with the G/G homozygote (n = 88). These data suggest that the COMT polymorphism affects serum ALT activity to maintain liver function. (C) 2012 Elsevier B.V. All rights reserved.

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  151. Prevalence of Helicobacter pylori infection measured with urinary antibody in an urban area of Japan, 2008-2010 Reviewed

    Tamura T, Morita E, Kondo T, Ueyama J, Tanaka T, Kida Y, Hori Y, Inoue S, Tomita K, Okada R, Kawai S, Hishida A, Naito M, Wakai K, Hamajima N.

    Nagoya J Med Sci   Vol. 74 ( 1-2 ) page: 63-70   2012.2

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  152. Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study Reviewed

    Asahi Hishida, Emi Morita, Mariko Naito, Rieko Okada, Kenji Wakai, Keitaro Matsuo, Kazuyo Nakamura, Naoyuki Takashima, Sadao Suzuki, Toshiro Takezaki, Haruo Mikami, Keizo Ohnaka, Yoshiyuki Watanabe, Hirokazu Uemura, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima

    ENDOCRINE JOURNAL   Vol. 59 ( 7 ) page: 589 - 99   2012

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    This study examined the associations of the APOA5 T-1131C (rs662799), G553T (Cys185Gly, rs2075291), GCK G-30A (rs1799884), GCKR A/G at intron 16 (rs780094) and T1403C (Leu446Pro, rs1260326) polymorphisms with scrum lipid and glucose levels in Japanese, considering lifestyle factors. Study subjects were 2,191 participants (aged 35-69 years, 1,159 males) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Dyslipidemia was defined as fasting serum triglycerides (FTG) &gt;= 150 mg/dL and/or HDL-cholesterol (HDL-C) &lt;40 mg/dL, while dysglycemia was as fasting blood sugar (FBS) &gt;= 110 mg/dL. When those with APOA5 -1131 T/Tor 553 G/G were defined as references, those with APOA5 -1131 TIC, C/C or 553 G/T, T/T demonstrated significantly elevated risk of dyslipidemia (age- and sex-adjusted odds ratio: 1.77 [95% confidence interval:1.39-2.27], 3.35 [2.41-4.65], 2.23 [1.64-3.02] and 13.78 [3.44-55.18], respectively). Evaluation of FTG, HDL-C or FBS levels according to the genotype revealed that FIG and HDL-C levels were significantly associated with the APOA5T-1131C and G553Tpolymorphisms, FIG with the GCKR rs780094 and rs1260326 polyrnorphisms, and FBS with the GCICR rs780094 and rs1260326 polymorphisms. Moreover, a significant positive interaction between APOA5 553 G/T+T/T genotypes and fat intake &gt;= 25% of total energy for the risk of dyslipidemia was observed. Our cross-sectional study confirmed the essential roles of the polymorphisms of the APOA5, GCK and GCKR in the lipid or glucose metabolism disorders, and suggested the importance of fat intake control in the individualized prevention of dyslipidemia.

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  153. Matrix Metalloproteinase-9 Gene Polymorphisms and Chronic Kidney Disease Reviewed

    Rieko Okada, Sayo Kawai, Mariko Naito, Asahi Hishida, Nobuyuki Hamajima, Koichi Shinchi, Tanvir Chowdhury Turin, Sadao Suzuki, Eva Mariane Mantjoro, Kengo Toyomura, Kokichi Arisawa, Nagato Kuriyama, Satoyo Hosono, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, Kenji Wakai

    AMERICAN JOURNAL OF NEPHROLOGY   Vol. 36 ( 5 ) page: 444 - 50   2012

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    Background: The aim of this study was to explore the associations between the prevalence of chronic kidney disease (CKD) and polymorphisms in the genes encoding matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs). MMPs degrade extracellular matrix proteins in the glomerulus, and play important roles in kidney disease progression. Methods: DNA samples from 3,309 subjects aged 35-69 years were genotyped for 10 potentially functional polymorphisms in MMP and TIMP genes. The prevalence of CKD (estimated glomerular filtration rate ! 60 ml/min/1.73 m(2)) was compared among the genotypes. Results: The prevalence of CKD decreased significantly with the number of minor alleles in MMP9 C-1562T (odds ratios (ORs) 0.77 for CT and 0.65 for TT compared with CC; p for trend = 0.023) and MMP9 R668Q (ORs, 0.79 for RQ and 0.64 for QQ compared with RR; p for trend = 0.024). The haplotype MMP9 -1562T/279R/668Q showed a reduced risk for CKD compared with the most common -1562C/279R/668R (OR 0.77, p = 0.008), and the genotype combination -1562TT/279RR/668QQ showed a halved risk for CKD compared with major allele homozygous -1562CC/279RR/668RR (OR 0.53, p = 0.091). Conclusion: The potentially functional polymorphisms of MMP9 were associated with the prevalence of CKD in a large Japanese population. These genotypes have been reported to increase MMP9 expression, supporting the hypothesis that MMP-9 has a protective role in the progression of kidney diseases. Copyright (C) 2012 S. Karger AG, Basel

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  154. Association between KLK3 rs2735839 G/A Polymorphism and Serum PSA Levels in Japanese Men Reviewed

    Syunsuke Nobata, Asahi Hishida, Mariko Naito, Yatami Asai, Atsuyoshi Mori, Mayumi Kuwabara, Shiro Katase, Rieko Okada, Emi Morita, Sayo Kawai, Nobuyuki Hamajima, Kenji Wakai

    UROLOGIA INTERNATIONALIS   Vol. 89 ( 1 ) page: 39 - 44   2012

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    Objectives: To clarify the association of kallikrein-related peptidase 3 (KLK3) rs2735839 G/A polymorphism with serum prostate-specific antigen (PSA) levels in Japanese men. Methods: Subjects were participants of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study who visited the Seirei Preventive Health Care Center in Shizuoka, Japan. Among the 5,040 individuals aged 35-69 years who were enrolled in 2006-2007, serum PSA data were available for 2,323 male subjects without a past history of prostate cancer. The diagnostic criteria for PSA positivity was PSA &gt;= 4.0 ng/ml. Genotyping of the KLK3 polymorphism was conducted by the polymerase chain reaction with the confronting two-pair primers (PCR-CTPP) method. Results: The mean +/- SD of PSA levels (mg/dl) were 1.54 +/- 1.73 for those with KLK3 rs2735839 GIG genotype, 1.34 +/- 1.33 for G/A, and 1.20 +/- 1.23 for A/A, which was significantly different (p &lt; 0.0001). The age-adjusted odds ratios of PSA test positivity were 0.62 (95% confidence interval 0.41-0.94) for those with G/A + A/A relative to those with G/G. Conclusions: The present study revealed that the KLK3 rs2735839 G allele was significantly associated with higher serum PSA levels also in Japanese. Copyright (C) 2012 S. Karger AG, Basel

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  155. ASSOCIATION OF OBESITY AND DIABETES WITH SERUM PROSTATE-SPECIFIC ANTIGEN LEVELS IN JAPANESE MALES

    Naito, Mariko, Asai, Yatami, Mori, Atsuyoshi, Fukada, Yuko, Kuwabara, Mayumi, Katase, Shiro, Hishida, Asahi, Morita, Emi, Kawai, Sayo, Okada, Rieko, Nishio, Kazuko, Tamakoshi, Akiko, Wakai, Kenji, Hamajima, Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 74 ( 3-4 ) page: 285 - 292   2012

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  156. No association between the frequency of forest walking and blood pressure levels or the prevalence of hypertension in a cross-sectional study of a Japanese population Reviewed

    Emi Morita, Mariko Naito, Asahi Hishida, Kenji Wakai, Atsuyoshi Mori, Yatami Asai, Rieko Okada, Sayo Kawai, Nobuyuki Hamajima

    Environmental Health and Preventive Medicine   Vol. 16 ( 5 ) page: 299 - 306   2011.9

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    Objective: To study the non-temporary effects of successive walks in forested areas (shinrin-yoku) on hypertension prevalence and blood pressure levels. Methods: Data for the analysis were derived from the baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study in the Shizuoka area. Eligible participants were individuals aged 35-69 years who attended a health check-up center during 2006 and 2007. Of the 5,040 individuals who participated in the J-MICC study, Shizuoka, 4,666 were included in this analysis [3,174 men and 1,492 women
    age (mean ± standard deviation) 52.1 ± 8.7 years]. The frequency of forest walking was estimated by a self-administrated questionnaire. Hypertension was defined as a systolic blood pressure ≥140 mmHg, a diastolic blood pressure ≥90 mmHg or, based on information provided in the questionnaire, the use of medication for hypertension. Results: After adjusting for age, body mass index (BMI), smoking status, alcohol consumption, and habitual exercise, the odds ratios of hypertension associated with forest walking once a week or more frequently, relative to less than once a month were 0.98 in men [95% confidence interval (CI) 0.68-1.42] and 1.48 (95% CI 0.80-2.71) in women. There was no significant trend between adjusted blood pressure levels and the frequency of forest walking. Conclusion: The results of our cross-sectional study in a Japanese population show no association between either blood pressure levels or the prevalence of hypertension and the frequency of forest walking. © 2011 The Japanese Society for Hygiene.

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  157. Significant association of serum uric acid levels with SLC2A9 rs11722228 among a Japanese population Reviewed

    Hamajima N, Okada R, Kawai S, Hishida A, Morita E, Yin G, Wakai K, Matsuo H, Inoue H, Takada Y, Asai Y, Mori A, Naito M.

    Mol Genet Metab   Vol. 103 ( 4 ) page: 378-382   2011.8

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  158. Study profile on baseline survey of Daiko Study in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) Reviewed

    Morita E, Hamajima N, Hishida A, Aoyama K, Okada R, Kawai S, Tomita K, Kuriki S, Tamura T, Naito M, Kondo T, Ueyama J, Kimata A, Yamamoto K, Hori Y, Hoshino J, Hamamoto R, Tsukamoto S, Onishi J, Hagikura S, Naito H, Hibi S, Ito Y, Wakai K.

    Nagoya J Med Sci   Vol. 73 ( 3-4 ) page: 187-195   2011.8

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  159. ASSOCIATION BETWEEN THE RANK POLYMORPHISM AND THE NUMBER OF TEETH AMONG JAPANESE

    M. Naito, Y. Asai, A. Mori, M. Kuwabara, A. Okamoto, S. Katase, A. Hishida, E. Morita, S. Kawai, R. Okada, K. Wakai, N. Hamajima

    JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH   Vol. 65   page: A280 - A280   2011.8

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  160. Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Reviewed

    Wakai K, Hamajima N, Okada R, Naito M, Morita E, Hishida A, Kawai S, Nishio K, Yin G, Asai Y, Matsuo K, Hosono S, Ito H, Watanabe M, Kawase T, Suzuki T, Tajima K, Tanaka K, Higaki Y, Hara M, Imaizumi T, Taguchi N, Nakamura K, Nanri H, Sakamoto T, Horita M, Shinchi K, Kita Y, Turin T C, Rumana N, Matsui K, Miura K, Ueshima H, Takashima N, Nakamura Y, Suzuki S, Ando R, Hosono A, Imaeda N, Shibata K, Goto C, Hattori N, Fukatsu M, Yamada T, Tokudome S, Takezaki T, Niimura H, Hirasada K, Nakamura A, Tatebo M, Ogawa S, Tsunematsu N, Chiba S, Mikami H, Kono S, Ohnaka K, Takayanagi R, Watanabe Y, Ozaki E, Shigeta M, Kuriyama N, Yoshikawa A, Matsui D, Watanabe I, Inoue K, Ozasa K, Mitani S, Arisawa K, Uemura H, Hiyoshi M, Takami H, Yamaguchi M, Nakamoto M, Takeda H, Kubo M, Tanaka H, for the J-MICC Study Group.

    J Epidemiol   Vol. 21 ( 3 ) page: 223-235   2011.5

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  161. Combined Effect of miR-146a rs2910164 G/C Polymorphism and Toll-like Receptor 4+3725 G/C Polymorphism on the Risk of Severe Gastric Atrophy in Japanese Reviewed

    Asahi Hishida, Keitaro Matsuo, Yasuyuki Goto, Mariko Naito, Kenji Wakai, Kazuo Tajima, Nobuyuki Hamajima

    DIGESTIVE DISEASES AND SCIENCES   Vol. 56 ( 4 ) page: 1131 - 7   2011.4

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    A G/C polymorphism in miRNA-146a (rs2910164) was shown to be associated with the risk of hepatocellular carcinoma.
    This study aimed to examine the associations of the miR-146a G/C (rs2910164) and TLR4 +3725 G/C (rs11536889) polymorphisms with the risk of Helicobacter pylori (H. pylori) infection, gastric atrophy, and gastric cancer in a Japanese population.
    Subjects for this study were 583 histologically diagnosed gastric cancer patients and age- and sex-frequency-matched 1,742 control outpatients (1,637 subjects were eligible for the analyses), who visited Aichi Cancer Center Hospital from the year 2001 to 2005. Serum pepsinogens were measured to evaluate gastric atrophy.
    When H. pylori-seropositive subjects or subjects with gastric atrophy were defined as H. pylori-infected subjects, the age- and sex-adjusted odds ratio (aOR) of severe gastric atrophy among the H. pylori infected was 1.44 (95% confidence interval [95% CI] = 0.89-2.34, p = 0.133) in G/G genotype of miR-146a polymorphism. When combined with TLR4 G/C polymorphism, the OR in those with miR-146a G/G and TLR4 G/C+C/C genotypes was significantly increased relative to those with miR-146a C/C+G/C and TLR4 G/G among the H. pylori-infected subjects: aOR = 2.04 (95% CI = 1.10-3.82, p = 0.025).
    This study revealed the combined effect of miR-146a rs2910164 G/G and TLR4 +3725 C allele on the increased risk of severe gastric atrophy among the H. pylori-infected Japanese subjects.

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  162. Serum uric acid distribution according to SLC22A12 W258X genotype in a cross-sectional study of a general Japanese population Reviewed

    Hamajima N, Naito M, Hishida A, Okada R, Asai Y, Wakai K.

    BMC Med Genet   Vol. 12 ( 1 ) page: 33   2011.3

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  163. Association of UGT1A1 Gly71Arg with urine urobilinogen. Reviewed

    Kataoka R, Kimata A, Yamamoto K, Hirosawa N, Ueyama J, Kondo T, Okada R, Kawai S, Hishida A, Naito M, Morita E, Wakai K, Hamajima N

    Nagoya journal of medical science   Vol. 73 ( 1-2 ) page: 33 - 40   2011.2

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  164. ASSOCIATION OF UGT1A1 GLY71ARG WITH URINE UROBILINOGEN

    Kataoka, Ryuji, Kimata, Akiko, Yamamoto, Kanami, Hirosawa, Naoko, Ueyama, Jun, Kondo, Takaaki, Okada, Rieko, Kawai, Sayo, Hishida, Asahi, Naito, Mariko, Morita, Emi, Wakai, Kenji, Hamajima, Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 73 ( 1-2 ) page: 33 - 40   2011

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  165. Combined effect of miR-146a rs2910164 G/C polymorphism Reviewed

    Hishida A, Matsuo K, Goto Y, Naito M, Wakai W, Tajima K, Hamajima N

    Dig Dis Sci   Vol. 56   page: 1131-1137   2011

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  166. No associations of Toll-like receptor 2 (TLR2)-196 to-174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese Reviewed

    Asahi Hishida, Keitaro Matsuo, Yasuyuki Goto, Mariko Naito, Kenji Wakai, Kazuo Tajima, Nobuyuki Hamajima

    GASTRIC CANCER   Vol. 13 ( 4 ) page: 251 - 7   2010.11

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    Recently, the association between gastric cancer risk and a functional polymorphism of Toll-like receptor 2 (TLR2), -196 to -174del, was reported for a Japanese population. This study aimed to confirm the associations of the polymorphism with the risk of gastric cancer, as well as Helicobacter pylori seropositivity and the risk of gastric atrophy in Japanese.
    The study subjects were 583 histologically diagnosed gastric cancer patients and 1636 age- and sex-frequencymatched control outpatients who visited Aichi Cancer Center Hospital from the years 2001 to 2005. Serum anti-H. pylori IgG antibody and pepsinogens were measured to evaluate H. pylori infection and gastric atrophy, respectively. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by a logistic model.
    The age- and sex-adjusted ORs of gastric cancer were 1.13 (95% CI: 0.88-1.46) for ins/del, 1.17 (95% CI: 0.79-1.73) for del/del, and 1.14 (95% CI: 0.89-1.45) for ins/del + del/del, relative to the ins/ins genotype compared with gastric atrophy controls; none of these findings were statistically significant. The TLR2 -196 to 174del polymorphism was not significantly associated with either H. pylori seropositivity or gastric atrophy.
    Our study did not reproduce the association between gastric cancer risk and the TLR2 -196 to -174del polymorphism in Japanese. Further examinations with sufficient numbers of study subjects are required to verify our findings.

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  167. Genetic predisposition to Helicobacter pylori-induced gastric precancerous conditions Reviewed

    Asahi Hishida, Keitaro Matsuo, Yasuyuki Goto, Nobuyuki Hamajima

    WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY   Vol. 2 ( 10 ) page: 369 - 79   2010.10

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    Gastric cancer is the most common malignancy of the gastrointestinal tract in East Asian populations and the second most frequent cause of cancer-related mortality in the world. While previous studies have investigated the genetic factors involved in gastric carcinogenesis, there still exist relatively few studies that have investigated the genetic traits associated with the risk of gastric precancerous conditions. In this paper we will review the biology and genetic polymorphisms involved in the genesis of gastric precancerous conditions reported to date and discuss the future prospects of this field of study. The associations of gastric precancerous conditions with polymorphisms in the cytotoxin-associated gene A-related genes (e.g. PTPN11 G/A at intron 3, rs2301756), those in the genes involved in host immunity against Helico-bacter pylori (H. pylori) infection (e.g. TLR4 + 3725G/C, rs11536889) or polymorphisms of the genes essential for the development/differentiation of the gastric epithelial cells (e.g. RUNX3 T/A polymorphism at intron 3, rs760805) have been reported to date. Genetic epide-miological studies of the associations between H. pylori induced gastric precancerous conditions and other gene polymorphisms in these pathways as well as polymorphisms of the genes involved in other pathways like oxidative DNA damage repair pathways would provide useful evidence for the individualized prevention of these H. pylori -induced gastric precancerous conditions. (C) 2010 Baishideng. All rights reserved.

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  168. 人間ドック受診者を対象とした静岡県中西部地区における森林散策頻度に関する大規模調査 Reviewed

    森田えみ, 内藤真理子, 西尾和子, 石田喜子, 菱田朝陽, 若井建志, 浅井八多美, 浜島信之.

    日林誌   Vol. 92 ( 2 ) page: 110-114   2010.6

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  169. PRKCH gene polymorphism is associated with the risk of severe gastric atrophy Reviewed

    Goto Y, Hishida A, Matsuo K, Tajima K, Morita E, Naito M, Wakai K, Hamajima N.

    Gastric Cancer   Vol. 13 ( 2 ) page: 90-94   2010.6

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  170. Genetic traits for the persistence of Helicobacter pylori infection Reviewed

    Hamajima N, Hishida A.

    Personalized Med   Vol. 7 ( 3 ) page: 249-262   2010.5

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  171. Genetic traits for the persistence of Helicobacter pylori infection Reviewed

    Nobuyuki Hamajima, Asahi Hishida

    PERSONALIZED MEDICINE   Vol. 7 ( 3 ) page: 249 - 262   2010.5

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    Helicobacter pylori infection elevates the risk of gastric diseases, including peptic ulcer and gastric cancer. Persistent infection is the first step to induce H. pylori-induced multistage diseases. Although the roles of genetic traits on persistent infection have not yet been elucidated, some individuals escape from persistent infection. Possible favorable conditions for H. pylori seem to be low acid secretion, reduced innate immune responses, and easier binding to gastric epithelial cells. IL-1 beta and TNF-alpha inhibit acid secretion. The genetic polymorphisms associated with both molecules have the potential to be the genetic traits underlying persistent infection. Functional polymorphisms associated with innate immune responses could also be involved with the genetic traits, but no polymorphisms with consistent associations have been identified so far. The polymorphisms associated with molecules for adhesion to epithelial cells are candidates of genetic traits, but more research is needed.

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  172. Associations of plasma IL-8 levels with Helicobacter pylori seropositivity, gastric atrophy, and IL-8 T-251A genotypes

    Naito, M, Eguchi, H, Goto, Y, Kondo, T, Nishio, K, Ishida, Y, Kawai, S, Okada, R, Hishida, A, Wakai, K, Hamajima, N

    EPIDEMIOLOGY AND INFECTION   Vol. 138 ( 4 ) page: 512 - 518   2010.4

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    DOI: 10.1017/S0950268809990677

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  173. Association between circulating IL-8 levels, IL-8 T-251A genotypes and Helicobacter pylori infection Reviewed

    Naito M, Eguchi H, Goto Y, Kondo T, Nishio K, Ishida Y, Kawai S, Okada R, Hishida A, Wakai K, Hamajima N

    Epidemiol Infect   Vol. 138   page: 512-518   2010.4

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  174. No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese Reviewed

    Asahi Hishida, Keitaro Matsuo, Yasuyuki Goto, Yoko Mitsuda, Akio Hiraki, Mariko Naito, Kenji Wakai, Kazuo Tajima, Nobuyuki Hamajima

    GASTRIC CANCER   Vol. 13 ( 1 ) page: 43 - 9   2010.3

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    The aberrant expression of activation-induced cytidine deaminase (AICDA) was reportedly induced in gastric epithelial cells infected with cytotoxin-associated gene A (cagA)-positive Helicobacter pylori, resulting in the accumulation of alterations in the TP53 tumor suppressor gene in gastric cells. We investigated the association of the AICDA 7888 C/T polymorphism with H. pylori infection and the risk of gastric cancer and atrophic gastritis in Japanese subjects.
    The study subjects were 583 histologically diagnosed gastric cancer patients (cases) and 1637 age- and sexfrequency-matched control outpatients, who visited Aichi Cancer Center Hospital from the years 2001 to 2005. In the controls, serum anti-H. pylori IgG antibody and pepsinogens were measured to evaluate H. pylori infection and atrophic gastritis, respectively. Odds ratios (ORs) and 95% confi dence intervals (CIs) were calculated by a logistic model.
    H. pylori seropositivity in the controls was not signifi cantly associated with the AICDA 7888 C/T genotypes. Among the H. pylori seropositive control subjects, the ageand sex-adjusted ORs of atrophic gastritis were not statistically signifi cant: 0.84 (95% CI, 0.62-1.13) for C/T, 0.82 (95% CI, 0.56-1.21) for T/T, and 0.83 (95% CI, 0.63-1.11) for C/T+T/T, relative to the C/C genotype. The age- and sexadjusted ORs of gastric cancer relative to atrophic gastritis were also not statistically signifi cant, at 1.17 (95% CI 0.89-1.54), 1.21 (95% CI, 0.85-1.71), and 1.18 (95% CI, 0.91-1.53), respectively. The OR of gastric cancer cases compared with the whole cohort of control subjects was also not signifi cant.
    The hypothetical association of the AICDA 7888 C/T polymorphism with the risk of gastric cancer or gastric atrophy was not shown in this study.

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  175. Efficacy of genotype notification to Japanese smokers on smoking cessation-An intervention study at workplace Reviewed

    Asahi Hishida, Tetsuro Terazawa, Toshiko Mamiya, Hidemi Ito, Keitaro Matsuo, Kazuo Tajima, Nobuyuki Hamajima

    CANCER EPIDEMIOLOGY   Vol. 34 ( 1 ) page: 96 - 100   2010.2

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    Objectives: It is well-known that smoking causes many diseases including cancers. Informing smokers of their genotypes associated with the vulnerability to the harms of smoking may be effective measures for smoking cessation. The present study examined the effects of genotype notification of an oncogene (L-myc) genotype to smokers on their behavior to quit smoking. Methods: Subjects were 562 employees of a bank who answered to be a smoker for a questionnaire used at annual health checkup at workplace from July to December 2002. Those enrolled on August, October, and December were allocated into the genotype notification group (intervention group), and the rest into the controls. Among 286 smokers allocated into the intervention group, 257 participants (89.9%) agreed to genotype testing. One year after the enrollment, a follow-up questionnaire survey was conducted for all smokers including controls. Results: Those who stated to have quitted smoking were 22 (8.0%) among the 276 controls and 15(5.8%) among the 257 genotype notified participants, providing that the odds ratio (OR) of cessation for the intervention was 0.64 (95% confidence interval, 0.32-1.28). No psychological problems associated with genotype notification were observed. Conclusion: The present study did not show positive effects of genotype notification on smoking cessation rate. To elevate the cessation rate, methods to explain and notify genotypes should be improved. (C) 2009 Elsevier Ltd. All rights reserved.

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  176. Smoking behavior and risk of Helicobacter pylori infection, gastric atrophy and gastric cancer in Japanese Reviewed

    Hishida A, Matsuo K, Goto Y, Naito M, Wakai K, Tajima K, Hamajima N.

    Asian Pac J Cancer Prev   Vol. 11 ( 2 ) page: 313-317   2010

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  177. 人間ドック受診者を対象とした静岡県中西部地区における森林散策頻度に関する大規模調査.

    森田えみ, 内藤真理子, 西尾和子, 石田喜子, 菱田朝陽, 若井建志, 浅井八多美, 浜島信之

    日林誌   Vol. 92   page: 110 - 114   2010

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  178. Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese Reviewed

    Hishida A, Matsuo K, Goto Y, Mitsuda Y, Naito M, Wakai K, Tajima K, Hamajima N.

    J Gastroenterol   Vol. 44 ( 12 ) page: 1165-1171   2009.12

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    DOI: 10.1007/s00535-009-0118-7

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  179. Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population Reviewed

    Hirotaka Matsuo, Tappei Takada, Kimiyoshi Ichida, Takahiro Nakamura, Akiyoshi Nakayama, Yuki Ikebuchi, Kousei Ito, Yasuyoshi Kusanagi, Toshinori Chiba, Shin Tadokoro, Yuzo Takada, Yuji Oikawa, Hiroki Inoue, Koji Suzuki, Rieko Okada, Junichiro Nishiyama, Hideharu Domoto, Satoru Watanabe, Masanori Fujita, Yuji Morimoto, Mariko Naito, Kazuko Nishio, Asahi Hishida, Kenji Wakai, Yatami Asai, Kazuki Niwa, Keiko Kamakura, Shigeaki Nonoyama, Yutaka Sakurai, Tatsuo Hosoya, Yoshikatsu Kanai, Hiroshi Suzuki, Nobuyuki Hamajima, Nariyoshi Shinomiya

    SCIENCE TRANSLATIONAL MEDICINE   Vol. 1 ( 5 ) page: 5ra11   2009.11

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    Gout based on hyperuricemia is a common disease with a genetic predisposition, which causes acute arthritis. The ABCG2/BCRP gene, located in a gout-susceptibility locus on chromosome 4q, has been identified by recent genome-wide association studies of serum uric acid concentrations and gout. Urate transport assays demonstrated that ABCG2 is a high-capacity urate secretion transporter. Sequencing of the ABCG2 gene in 90 hyperuricemia patients revealed several nonfunctional ABCG2 mutations, including Q126X. Quantitative trait locus analysis of 739 individuals showed that a common dysfunctional variant of ABCG2, Q141K, increases serum uric acid. Q126X is assigned to the different disease haplotype from Q141K and increases gout risk, conferring an odds ratio of 5.97. Furthermore, 10% of gout patients (16 out of 159 cases) had genotype combinations resulting in more than 75% reduction of ABCG2 function (odds ratio, 25.8). Our findings indicate that nonfunctional variants of ABCG2 essentially block gut and renal urate excretion and cause gout.

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  180. Baseline data of Shizuoka area in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). Reviewed

    Asai Y, Naito M, Suzuki M, Tomoda A, Kuwabara M, Fukada Y, Okamoto A, Oishi S, Ikeda K, Nakamura T, Misu Y, Katase S, Tokumasu S, Nishio K, Ishida Y, Hishida A, Morita E, Kawai S, Okada R, Wakai K, Tamakoshi A, Hamajima N

    Nagoya journal of medical science   Vol. 71 ( 3-4 ) page: 137 - 144   2009.9

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  181. Associations of diabetes mellitus and BMI with the prostate-specific antigen concentration in Japanese men

    NAITO Mariko, HISHIDA Asahi, WAKAI Kenji, MORITA Emi, KAWAI Sayo, OKADA Rieko, TAMAKOSHI Akiko, HAMAJIMA Nobuyuki

    日本癌学会学術総会記事   Vol. 68th   page: 343   2009.8

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  182. Smoking cessation, alcohol intake and transient increase in the risk of metabolic syndrome among Japanese smokers at one health checkup institution Reviewed

    Hishida A, Koyama A, Tomoda A, Katase S, Asai Y, Hamajima N.

    BMC Public Health   Vol. 9 ( 1 ) page: 263   2009.7

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    DOI: 10.1186/1471-2458-9-263.

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  183. Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese Reviewed

    Asahi Hishida, Keitaro Matsuo, Yasuyuki Goto, Mariko Naito, Kenji Wakai, Kazuo Tajima, Nobuyuki Hamajima

    BMC GASTROENTEROLOGY   Vol. 9 ( 1 ) page: 51   2009.7

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    Background: Previous studies have revealed the significance of Helicobacter pylori (H. pylori) infection as a risk factor of gastric cancer. Cytotoxin-associated gene A (cagA) positivity has been demonstrated to determine the clinical outcome of H. pylori infection in the presence of SHP-2 (src homology 2 domain-containing protein tyrosine phosphatase-2). This study aimed to examine the formerly reported association of G/A PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) polymorphism (rs2301756) with gastric atrophy, as well as the association with gastric cancer in a Japanese population using a large sample size.
    Methods: Study subjects were 583 histologically diagnosed patients with gastric cancer (429 males and 154 females) and age-and sex-frequency-matched 1,636 non-cancer outpatients (1,203 males and 433 females), who visited Aichi Cancer Center Hospital between 2001-2005. Serum anti-H. pylori IgG antibody and pepsinogens were measured to evaluate H. pylori infection and gastric atrophy, respectively. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by a logistic model.
    Results: Among H. pylori seropositive non-cancer outpatients, the age-and sex-adjusted OR of gastric atrophy was 0.82 (95% CI 0.62-1.10, P = 0.194) for G/A, 0.84 (95% CI 0.39-1.81, P = 0.650) for A/A, and 0.83 (95% CI 0.62-1.09, P = 0.182) for G/A+A/A, relative to G/G genotype, and that of severe gastric atrophy was 0.70 (95% CI 0.47-1.04, P = 0.079), 0.56 (95% CI 0.17-1.91, P = 0.356), and 0.68 (95% CI 0.46-1.01, P = 0.057), respectively. Among H. pylori infected subjects (H. pylori seropositive subjects and seronegative subjects with gastric atrophy), the adjusted OR of severe gastric atrophy was further reduced; 0.62 (95% CI 0.42-0.90, P = 0.012) for G/A+A/A. The distribution of the genotype in patients with gastric cancer was not significantly different from that for H. pylori infected subjects without gastric atrophy.
    Conclusion: Our study results revealed that those with the A/A genotype of PTPN11 rs2301756 polymorphism are at lower risk of severe gastric atrophy, but are not associated with a decreased risk of gastric cancer, which partially supported our previous finding that the polymorphism in the PTPN11 gene encoding SHP-2 was associated with the gastric atrophy risk in H. pylori infected Japanese. The biological roles of this PTPN11 polymorphism require further investigation.

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  184. Toll-like receptor 4 +3725 G/C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese Reviewed

    Hishida A, Matsuo K, Goto Y, Mitsuda Y, Hiraki A, Naito M, Wakai K, Tajima K, Hamajima N.

    Helicobacter   Vol. 14 ( 1 ) page: 47-53   2009.2

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  185. RUNX3 polymorphisms, Helicobacter pylori seropositivity, and risk of gastric atrophy and cancer in Japanese Reviewed

    Hishida A, Matsuo K, Goto Y, Mitsuda Y, Naito M, Wakai K, Tajima K, Hamajima N

    J Gastroenterol   Vol. 44   page: 1165-1171   2009

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  186. BASELINE DATA OF SHIZUOKA AREA IN THE JAPAN MULTI-INSTITUTIONAL COLLABORATIVE COHORT STUDY (J-MICC STUDY)

    Asai, Yatami, Naito, Mariko, Suzuki, Masumi, Tomoda, Akiko, Kuwabara, Mayumi, Fukada, Yuko, Okamoto, Ayumi, Oishi, Sachie, Ikeda, Kanako, Nakamura, Tsukino, Misu, Yasuko, Katase, Shiroh, Tokumasu, Satoshi, Nishio, Kazuko, Ishida, Yoshiko, Hishida, Asahi, Morita, Emi, Kawai, Sayo, Okada, Rieko, Wakai, Kenji, Tamakoshi, Akiko, Hamajima, Nobuyuki

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 71 ( 3-4 ) page: 137 - 144   2009

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  187. Controls for monitoring the deterioration of stored blood samples in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). Reviewed

    Naito M, Eguchi H, Okada R, Ishida Y, Nishio K, Hishida A, Wakai K, Tamakoshi A, Hamajima N, J-MICC Study Group

    Nagoya journal of medical science   Vol. 70 ( 3-4 ) page: 107 - 115   2008.8

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  188. 胃癌のリスクファクター, ハイリスクグループ Reviewed

    菱田朝陽, 浜島信之

    臨牀消化器内科   Vol. 23 ( 3 ) page: 351-355   2008.3

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  189. BMI-1 is highly expressed in MO-subtype acute myeloid leukemia Reviewed

    M Sawa, K Yamamoto, T Yokozawa, H Kiyoi, A Hishida, T Kajiguchi, M Seto, A Kohno, K Kitamura, Y Itoh, N Asou, N Hamajima, N Emi, T Naoe

    INTERNATIONAL JOURNAL OF HEMATOLOGY   Vol. 82 ( 1 ) page: 42 - 7   2005.7

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    Recent studies have suggested that one of the polycomb group genes, BMI-1, has an important role in the maintenance of normal and leukemic stem cells by repressing the INK4a/ARFlocus. Here, we quantitatively examined BMI-1 expression level in samples from patients with acute myeloid leukemia (AML) and other hematologic malignancies. Moderate to high BMI-1 expression was detected in AML patients, and the BMI-1 expression levels in AML samples were significantly higher than in normal bone marrow controls (P =.0011). Specimens of French-American-British classification subtype MO showed higher relative expression of the BMI-1 transcript (median, 390.2 X 10(-3)) than the other subtypes (median, 139.0 X 10-3) (p &lt;.0001). Leukemia other than AML showed low to moderate expression. INK4a-ARF transcript expression tended to be inverse proportion to that of BMI-1. In an MO patient with a high BMI-1 transcript level, the INK4a-ARF transcript level fell promptly and maintained a low value after the patient achieved complete remission. These results indicated that a subgroup of MO patients has a high expression level of polycomb group gene BMI-1, which may contribute to leukemogenesis.

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  190. Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese. Reviewed

    Tanaka D, Hishida A, Matsuo K, Iwata H, Shinoda M, Yamamura Y, Kato T, Hatooka S, Mitsudomi T, Kagami Y, Ogura M, Tajima K, Suyama M, Naito M, Yamamoto K, Tamakoshi A, Hamajima N

    Nagoya journal of medical science   Vol. 67 ( 3-4 ) page: 117 - 124   2005.6

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  191. HER2 codon 655 polymorphism and breast cancer: results from kin-cohort and case-control analyses Reviewed

    RC Millikan, AJ Hummer, MS Wolff, A Hishida, CB Begg

    BREAST CANCER RESEARCH AND TREATMENT   Vol. 89 ( 3 ) page: 309 - 12   2005.2

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    Several published epidemiologic studies show increased breast cancer risk for carriers of the Val-allele at codon 655 of the HER2 gene. We conducted additional analyses using data from three studies, including case-control analyses stratified on age and kin-cohort analyses using relatives of cases and controls. The results provide additional evidence that HER2 codon 655 genotype may predispose to early-onset breast cancer.

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  192. Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese Reviewed

    A Hishida, K Matsuo, K Tajima, M Ogura, Y Kagami, H Taji, Y Morishima, N Emi, T Naoe, N Hamajima

    LEUKEMIA & LYMPHOMA   Vol. 45 ( 5 ) page: 957 - 64   2004.5

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    We hypothesized that the polymorphisms in the two p53 family genes ( p53 Arg72Pro and p73 G4C14- to- A4T14 at exon 2 (G4A)) and p21 Ser31Arg polymorphism might modulate the risk of non-Hodgkin's lymphoma, and conducted a hospital-based prevalent case - control study at Aichi Cancer Center Hospital to clarify the association. Risk estimation for each genotype by the unconditional logistic model demonstrated the possible association between the p53 Pro72 allele and the risk of non-Hodgkin's lymphoma in Japanese population(OR = 1.59; 95% CI, 0.99 - 2.57, P= 0.057), although no other significant association was observed. The analyses of statistical interactions between these three polymorphisms ( p73 G4A, p53 Arg72Pro and p21 Ser31Arg polymorphisms) revealed the marginally significant OR for interaction between p53 Arg72Pro and p73 G4A polymorphisms (OR = 2.54; 95% CI, 0.97 - 6.62, P= 0.057). When those without p53 Pro72 and p73 A4T14 alleles were defined as a reference, those with p53 Pro72 and p73 A4T14 alleles demonstrated a significantly higher OR (2.08; 95% CI, 1.11 - 3.90, P= 0.023). Further examination with a sufficiently larger population and other ethnicities are required to confirm our findings.

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  193. Polymorphism in the hMSH2 gene (gIVS 12-6T -&gt; C) and risk of non-Hodgkin lymphoma in a Japanese population Reviewed

    A Hishida, K Matsuo, N Hamajima, H Ito, M Ogura, Y Kagami, H Taji, Y Morishima, N Emi, K Tajima

    CANCER GENETICS AND CYTOGENETICS   Vol. 147 ( 1 ) page: 71 - 4   2003.11

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    We conducted a hospital-based prevalent case-control study in a Japanese population (cases = 103, controls = 487) to ascertain the previous report about the association between the polymorphism in exon 13 of the hMSH2 gene (gIVS 12-6T--&gt;C) and the risk of non-Hodgkin lymphoma in an Ecuadorian population. When the TT genotype was defined as the reference, none of the CT genotypes (OR = 1.52; 95% CI, 0.97-2.37), CC genotypes (OR = 1.06, 95% CI, 0.44-2.54), or CT and CC genotypes combined together (OR = 1.44, 95% CI, 0.94-2.23) demonstrated significant OR. Further investigations with sufficiently larger populations and in other ethnicities are required to verify this association. (C) 2003 Elsevier Inc. All rights reserved.

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  194. Trisomy X in Philadelphia chromosome-negative cells during the course of Philadelphia chromosome-positive chronic myelocytic leukemia Reviewed

    Hishida A, Yamamoto K, Matsushita T, Tanimoto M, Saito H, Emi N.

    Cancer Genet Cytogenet   Vol. 142 ( 1 ) page: 83-85   2003.4

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  195. Recovery of normal hematopoiesis after severe bone marrow aplasia induced by interferon-alpha in a patient with chronic myelogenous leukemia Reviewed

    Hishida A, Yamamoto K, Kato C, Yokozawa T, Emi N, Tanimoto M, Saito H.

    Int J Hematol   Vol. 77 ( 1 ) page: 55-59   2003.1

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  196. Transforming growth factor B1 T29C polymorphism and breast cancer risk in Japanese women Reviewed

    Hishida A, Iwata H, Hamajima N, Matsuo K, Mizutani M, Iwase T, Miura S, Emi N, Hirose K, Tajima K.

    Breast Cancer   Vol. 10 ( 1 ) page: 63-69   2003.1

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    PubMed

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MISC 12

  1. GWASとSNP-set Kernel Association Tests(SKAT)により見出されたPSCA遺伝子とピロリ菌関連胃粘膜萎縮の関連(The association of PSCA gene and H. pylori-related gastric atrophy risk detected by GWAS and SKAT)

    菱田 朝陽, 藤井 亮輔, 中杤 昌弘, 川合 紗世, 伊藤 秀美, 松尾 恵太郎, 渡邉 美貴, 鈴木 貞夫, 栗山 長門, 内藤 真理子, 若井 建志

    日本癌学会総会記事   Vol. 77回   page: 1242 - 1242   2018.9

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    Language:English   Publisher:日本癌学会  

  2. Genome-wide association study of renal function traits with 1000 Genomes-based imputation in a large population-based Japanese cohort - data from the J-MICC Study Reviewed

    Asahi Hishida, Masahiro Nakatochi, Masato Akiyama, Yoichiro Kamatani, Takeshi Nishiyama, Hidemi Ito, Isao Oze, Yuichiro Nishida, Megumi Hara, Naoyuki Takashima, Tanvir Chowdhury Turin, Miki Watanabe, Sadao Suzuki, Rie Ibusuki, Ippei Shimoshikiryo, Yohko Nakamura, Haruo Mikami, Hiroaki Ikezaki, Norihiro Furusho, Kiyonori Kuriki, Kaori Endoh, Teruhide Koyama, Daisuke Matsui, Hirokazu Uemura, Kokichi Arisawa, Tae Sasakabe, Rieko Okada, Sayo Kawai, Mariko Naito, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai, The Japan Multi-Institutional Collaborative Cohort, J-MICC, Study Group

    American Journal of Nephrology   Vol. 47 ( 5 ) page: 304-316   2018.5

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    Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)  

    DOI: 10.1159/000488946

  3. The association between the TLR2 gene and risk of H. pylori-related gastric atrophy detected by SKAT

    Hishida Asahi, Fujii Ryosuke, Nakatochi Masahiro, Kawai Sayo, Oze Isao, Matsuo Keitaro, Tamai Yuya, Suzuki Sadao, Kuriyama Nagato, Watanabe Yoshiyuki, Naito Mariko, Wakai Kenji

    CANCER SCIENCE   Vol. 109   page: 767 - 767   2018.1

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    Web of Science

  4. SNP-set Kernel Association Tests(SKAT)により見出されたTLR2遺伝子とピロリ菌関連胃粘膜萎縮の関連

    菱田 朝陽, 藤井 亮輔, 中杤 昌弘, 川合 紗世, 尾瀬 功, 松尾 恵太郎, 玉井 裕也, 鈴木 貞夫, 栗山 長門, 渡邊 能行, 内藤 真理子, 若井 建志

    日本癌学会総会記事   Vol. 76回   page: P - 2389   2017.9

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  5. EPA-ENRICHED NUTRITION AS A COMBINED MODALITY THERAPY FOR CACHECTIC CANCER PATIENTS UNDERGOING SYSTEMIC CHEMOTHERAPY IN GASTROINTESTINAL CANCER

    Yoshinaga Okugawa, Yuji Toiyama, Yumiko Shirai, Asahi Hishida, Hiroyuki Fujikawa, Hiromi Yasuda, Shigeyuki Yoshiyama, Masaki Ohi, Toshimitsu Araki, Koji Tanaka, Yasuhiro Inoue, Motoyoshi Tanaka, Yasuhiko Mohri, Ajay Goel, Masato Kusunoki, Chikao Miki

    GASTROENTEROLOGY   Vol. 152 ( 5 ) page: S416 - S416   2017.4

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    Web of Science

  6. Metallothionein MT2A A-5G Polymorphism as a Risk Factor for Chronic Kidney Disease and Diabetes: Cross-Sectional and Cohort Studies Reviewed

    Hattori Y, Naito M, Satoh M, Nakatochi M, Naito H, Kato M, Takagi S, Matsunaga T, Seiki T, Sasakabe T, Suma S, Kawai S, Okada R, Hishida A, Hamajima N, Wakai K

    Toxicol Sci   Vol. 152 ( 1 ) page: 181-193   2016.7

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    DOI: 10.1093/toxsci/kfw080

    PubMed

  7. Significant Associations of Abdominal Obesity with LYPLAL1 Polymorphism (rs4846567) among a General Japanese Population: A Cross-Sectional Study.

    T. Tamura, E. Morita, S. Kawai, T. Sasakabe, N. Fukuda, Y. Sugimoto, S. Suma, J. Mokuno, H. Nakagawa, A. Hishida, R. Okada, M. Naito, N. Hamajima, K. Wakai

    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY   Vol. 44   page: 243 - 244   2015

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    Web of Science

  8. 健康な日本人成人の血清GGT値とGGT1intron1A/G遺伝子多型の関連

    川合紗世, 内藤真理子, 森田えみ, 岡田理恵子, 菱田朝陽, 若井建志, 浜島信之

    人間ドック   Vol. 28 ( 2 ) page: 296   2013.7

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    Language:Japanese  

    J-GLOBAL

  9. 痛風病因遺伝子ABCG2の変異が血清尿酸値におよぼす影響

    中山昌喜, 松尾洋孝, 高田雄三, 中島宏, 佐藤弘樹, 中村好宏, 森厚嘉, 内藤真理子, 菱田朝陽, 若井建志, 清水聖子, 及川雄二, 丹羽和紀, 櫻井裕, 市田公美, 浜島信之, 四ノ宮成祥

    Journal of Epidemiology   Vol. 23 ( Supplement 1 ) page: 152   2013.1

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    J-GLOBAL

  10. Toll-Like Receptor 4 +3725 G/C Polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese (vol 14, pg 47, 2009)

    Asahi Hishida, Keitaro Matsuo, Yasuyuki Goto, Yoko Mitsuda, Akio Hiraki, Mariko Naito, Kenji Wakai, Kazuo Tajima, Nobuyuki Hamajima

    HELICOBACTER   Vol. 14 ( 5 ) page: 151 - 152   2009.10

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    Web of Science

  11. ELISA法を用いたIL‐1B C‐31T,IL‐1RN VNTR遺伝子多型と血中IL‐1β,IL‐6レベルとの関連についての検討

    菱田朝陽, 江口英孝, 西尾和子, 石田喜子, 川合沙世, 岡田理恵子, 内藤真理子, 若井建志, 浜島信之

    J Epidemiol   Vol. 18 ( 1 Supplement ) page: 199   2008.1

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    J-GLOBAL

  12. BMI-1 overexpression in 32Dcl3 cells suppresses granulocytic differentiation and ameliorates their growth under IL-3 diminished conditions.

    A Hishida, K Yamamoto, M Sawa, T Naoe

    BLOOD   Vol. 106 ( 11 ) page: 133B - 133B   2005.11

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KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. Research of optimal nutrition to cancer patients with palliative care based on genome information

    Grant number:25460745  2013.4 - 2017.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Hishida Asahi, HAMAJIMA Nobuyuki

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    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    Using the data from 59 gastrointestinal cancer patients under palliative care who gave us informed consent, we conducted the analyses of the influence of genotypes on the survival and the risk of weight loss of these patients. As a result, significantly worse survival in those with the IL-1RN VNTR 2-repeat allele, those with the IL-6 -634 G/G genotype, or those with the IL-10 -1082 A/G genotype was observed (with the adjusted hazard ratios of 9.20, 41.01 or 6.49, respectively), whereas those with the AKT1 rs1130233 A allele had significantly increased risk of weight loss of more than 5% within 6 months (with the adjusted odds ratio of 4.57), suggesting the feasibility and usefulness of genetic testing in cancer palliative care.

  2. Gene-environment interaction in the genesis of Helicobacter pylori-induced gastric atrophy

    Grant number:20790422  2008 - 2009

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    HISHIDA Asahi

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    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    We confirmed the significant association of PTPN11 G/A polymorphism at intron 3 with the risk of H.pylori-induced gastric atrophy in Japanese, revealed that TLR4+3725 G/C polymorphism, a recently-found polymorphism of TLR4, was associated with the risk of H. pylori-induced severe gastric atrophy in Japanese, and also found the novel association of RUNX3 T/A polymorphism at intron 3 with the risk of H. pylori-induced gastric atrophy in Japanese. We feel convinced that we could provide useful evidence for the prevention of gastric atrophy as a precursor of gastric cancer in Japanese.

  3. Research on RNA as the early diagnostic marker of gastrointestinal and lung cancers using preserved samples of cohort studies

    Grant number:19K10598  2019.4 - 2022.3

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    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

  4. Investigation of genetic factors associated with the risk of Helicobacter pylori-induced gastric cancer and gastric atrophy by SNP-set analysis and their validation

    Grant number:16K09032  2016.4 - 2020.3

    Hishida Asahi

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    Authorship:Principal investigator 

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    We conducted the genome-wide association study (GWAS) of gastric atrophy (GA) (diagnosed based on pepsinogen 1 [PG1] <= 70ng/ml & PG1/PG2 <= 3), severe gastric atrophy (sGA) (PG1 <= 30ng/ml & PG1/PG2 <= 2) and PG1/PG2 ratio using the data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study (n = 3,385) and Hospital-based Epidemiologic Research Program at Aichi Cancer Center 2 (HERPACC2)(n = 2,885), and found that PSCA SNPs on 8q24.3, which also reportedly associate with the risk of Helicobacter pylori-induced gastric cancer, reached the GWAS significant levels, and subsequent SNP-set analysis supported these findings by the statistically significant associations of PSCA gene with each of the three traits of GA, sGA and PG1/PG2 ratio.

  5. がん化学療法時における栄養摂取量についてのゲノム情報を加味したエビデンスの確立

    2013.4 - 2016.3

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  6. ピロリ菌と胃粘膜萎縮発生における遺伝子環境交互作用に関する研究

    2008

    科学研究費補助金  若手研究(B),課題番号:20790422

    菱田 朝陽

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Academic Activities 2

  1. Editorial Board Member, BMC Medical Genetics

    Role(s):Review, evaluation, Peer review

    2018.1 - 2020.12

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    Type:Scientific advice/Review 

  2. Editorial Board Member, World Journal of Gastrointestinal Oncology

    Role(s):Review, evaluation, Peer review

    2016.1 - 2018.12

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    Type:Peer review