Updated on 2021/04/27

写真a

 
SUMIGAMA, Seiji
 
Organization
Graduate School of Medicine International Collaborative Program in Comprehensive Medical Science between Nagoya University and Lund University Designated lecturer
Title
Designated lecturer
Contact information
メールアドレス

Degree 1

  1. 医学博士 ( 2006.3   名古屋大学 ) 

Research Areas 2

  1. Others / Others  / Obstetrics and Gynecology

  2. Life Science / Medical management and medical sociology  / 国際医学教育

Research History 3

  1. Nagoya University

    2007.4

  2. 大垣市民病院 産婦人科医員

    2000.4 - 2002.3

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    Country:Japan

  3. 社会保険中京病院 臨床研修医

    1998.4 - 2000.3

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    Country:Japan

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    2003.4 - 2006.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1992.4 - 1998.3

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    Country: Japan

Professional Memberships 5

  1. 日本産科婦人科学会

  2. 日本周産期・新生児医学会

  3. 日本胎盤学会

  4. New European Surgical Academy (NESA)

  5. International Society of Clinical Medicine

Committee Memberships 4

  1. 日本胎盤学会   評議員  

    2017.4   

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    Committee type:学協会

  2. 愛知県母子保健運営協議会   委員  

    2015.8   

  3. 愛知県産婦人科医会   評議員  

    2015.6 - 2016.5   

  4. Journal of Obstetrics and Gynaecology Research (JOGR)   Associate Editor  

    2013.11   

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    Committee type:学協会

Awards 2

  1. 第62回日本産科婦人科学会学術講演会 グッドプレゼンテーション賞

    2010.4  

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    Country:Japan

  2. 尚和会学術奨励賞

    2008.12  

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    Country:Japan

 

Papers 57

  1. Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia

    Ito Yumiko, Tsuda Hiroyuki, Imai Kenji, Miki Rika, Miura Mayo, Tachi Asuka, Tano Sho, Hirako-Takamura Shima, Moriyama Yoshinori, Ushida Takafumi, Kobayashi Tomoko, Sumigama Seiji, Kajiyama Hiroaki, Kikkawa Fumitaka, Kotani Tomomi

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 700   page: 108769   2021.3

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.abb.2021.108769

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  2. Real prevalence of neural tube defects in Japan: How many of such pregnancies have been terminated?

    Kondo Atsuo, Akada Shinobu, Akiyama Kunihisa, Arakawa Masato, Ichi Shunsuke, Inamoto Yutaka, Ishida Tomohiko, Ishikawa Hiroshi, Itoh Tomonori, Izumi Akio, Kinnura Fuminori, Kondo Atsuya S., Matsuoka Ryu, Miyauchi Akito, Mochizuki Junko, Monnohara Yoshihito, Morikawa Shigehiko, Morioka Miki, Morota Nobuhito, Nakabe Ken, Obayashi Satoshi, Oku Masataka, Samura Osamu, Sasahara Jun, Sase Masakatsu, Shimamoto Kumi, Shimamura Katsunori, Sumigama Seiji, Tada Katsuhiko, Takahashi Hiroyuki, Tani Akihiro, Wada Seiji, Wada-Hlraike Osamu, Watanabe Tomoyuki, Yamaguchi Masatoshi, Yasui Tomoyo, Yokomine Masato

    CONGENITAL ANOMALIES   Vol. 59 ( 4 ) page: 118 - 124   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cga.12333

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  3. Joint Degree Program for Graduate Students at the Nagoya University Graduate School of Medicine

    Kasuya Hideki, Aleksic Branko, Sumigama Seiji, Bustos Itzel, Hasegawa Hitoki, Kasai Mika P., Kobayashi Miho, Samizo Yumiko

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page: 183 - 192   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.81.2.183

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  4. The role of E2F8 in the human placenta

    Mizuno Masako, Miki Rika, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Niimi Kaoru, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Senga Takeshi, Iwase Akira, Kikkawa Fumitaka, Kotani Tomomi

    MOLECULAR MEDICINE REPORTS   Vol. 19 ( 1 ) page: 293-301   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/mmr.2018.9617

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  5. A rare pseudo tumour in the extraembryonic coelom in first trimester of pregnancy: ultrasound and pathology

    Sumigama Seiji, Enomoto Atsushi, Matsukawa Satoshi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 39 ( 4 ) page: 545 - 546   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/01443615.2018.1511971

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  6. Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders

    Matsukawa Satoshi, Sumigama Seiji, Kotani Tomomi, Wang Jingwen, Miki Rika, Moriyama Yoshinori, Nakano Tomoko, Mano Yukio, Tsuda Hiroyuki, Tamakoshi Koji, Kikkawa Fumitaka

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 84 ( 4 ) page: 396 - 406   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000496609

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  7. The Current Status and Future Prospects of Oncolytic Viruses in Clinical Trials against Melanoma, Glioma, Pancreatic, and Breast Cancers

    Eissa Ibrahim Ragab, Bustos-Villalobos Itzel, Ichinose Toru, Matsumura Shigeru, Naoe Yoshinori, Miyajima Noriyuki, Morimoto Daishi, Mukoyama Nobuaki, Wu Zhiwen, Tanaka Maki, Hasegawa Hitoki, Sumigama Seiji, Aleksic Branko, Kodera Yasuhiro, Kasuya Hideki

    CANCERS   Vol. 10 ( 10 )   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers10100356

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  8. PLACENTAL PROTEOMIC ANALYSIS OF PLACENTA ACCRETA

    Moriyama Yoshinori, Sumigama Seiji, Mizutani Teruyuki, Nomoto Masataka, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka

    PLACENTA   Vol. 69   page: E74-E75   2018.9

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  9. The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis.

    Moroi H, Kotani T, Miki R, Tsuda H, Mizuno M, Ito Y, Ushida T, Imai K, Nakano T, Li H, Sumigama S, Yamamoto E, Iwase A, Kikkawa F

    Journal of clinical biochemistry and nutrition   Vol. 62 ( 1 ) page: 63-67   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3164/jcbn.16-103

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  10. Association of serum asymmetric dimethylarginine, homocysteine, and L-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy

    Maruta Ei, Wang Jingwen, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Imai Kenji, Sumigama Seiji, Niwa Yoshimitsu, Mitsui Takashi, Yoshida Shigeru, Yamashita Mamoru, Nawa Akihiro, Tamakoshi Koji, Kajiyama Hiroaki, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 475   page: 70-77   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cca.2017.10.007

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  11. Genomic Signature of the Natural Oncolytic Herpes Simplex Virus HF10 and Its Therapeutic Role in Preclinical and Clinical Trials.

    Eissa IR, Naoe Y, Bustos-Villalobos I, Ichinose T, Tanaka M, Zhiwen W, Mukoyama N, Morimoto T, Miyajima N, Hitoki H, Sumigama S, Aleksic B, Kodera Y, Kasuya H

    Frontiers in oncology   Vol. 7   page: 149   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fonc.2017.00149

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  12. Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia

    Hirako Shima, Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Nakano Tomoko, Imai Kenji, Li Hua, Toyokuni Shinya, Kikkawa Fumitaka

    PHYTOTHERAPY RESEARCH   Vol. 30 ( 9 ) page: 1474 - 1480   2016.9

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ptr.5645

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  13. Efficacy and safety of daikenchuto (TJ-100) in pregnant women with constipation

    Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Hayakawa Hiromi, Kikkawa Fumitaka

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   Vol. 55 ( 1 ) page: 26 - 29   2016.2

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tjog.2015.12.003

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  14. Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia

    Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Mano Yukio, Nakano Tomoko, Ushida Takafumi, Li Hua, Miki Rika, Sumigama Seiji, Iwase Akira, Hirakawa Akihiro, Ohno Kinji, Toyokuni Shinya, Takeuchi Hideyuki, Mizuno Tetsuya, Suzumura Akio, Kikkawa Fumitaka

    FREE RADICAL BIOLOGY AND MEDICINE   Vol. 91   page: 154 - 163   2016.2

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.freeradbiomed.2015.12.015

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  15. Relationship between the cortisol levels in umbilical cord blood and neonatal RDS/TTN in twin pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Nakano Tomoko, Hua Li, Kikkawa Fumitaka

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE   Vol. 29 ( 13 ) page: 2151 - 2156   2016

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/14767058.2015.1077510

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  16. Risk assessment for neonatal RDS/TTN using gestational age and the amniotic lamellar body count in twin pregnancies

    Tsuda Hiroyuki, Hirakawa Akihiro, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Nakano Tomoko, Imai Kenji, Kawabata Ichiro, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 451 ( Pt B ) page: 301 - 304   2015.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cca.2015.10.013

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  17. Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury

    Nakano Tomoko, Kotani Tomomi, Mano Yukio, Tsuda Hiroyuki, Imai Kenji, Ushida Takafumi, Li Hua, Miki Rika, Sumigama Seiji, Sato Yoshiaki, Iwase Akira, Hirakawa Akihiro, Asai Masato, Toyokuni Shinya, Kikkawa Fumitaka

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 57 ( 3 ) page: 178 - 182   2015.11

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3164/jcbn.15-90

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  18. Is the serum L-arginine level during early pregnancy a predictor of pregnancy-induced hypertension?

    Wang Jingwen, Kotani Tomomi, Tsuda Hiroyuki, Mano Yukio, Sumigama Seiji, Li Hua, Komatsu Koji, Miki Rika, Maruta Ei, Niwa Yoshimitsu, Mitsui Takashi, Yoshida Shigeru, Yamashita Mamoru, Tamakoshi Koji, Kikkawa Fumitaka

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 57 ( 1 ) page: 74 - 81   2015.7

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    DOI: 10.3164/jcbn.14-104

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  19. Amniotic lamellar body count: predicting and distinguishing neonatal respiratory complications in twin pregnancies

    Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Kawabata Ichiro, Takahashi Yuichiro, Iwagaki Shigenori, Hirakawa Akihiro, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 441   page: 75 - 78   2015.2

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    DOI: 10.1016/j.cca.2014.12.019

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  20. Catalytic ferrous iron in amniotic fluid as a predictive marker of human maternal-fetal disorders

    Hattori Yuka, Mukaide Takahiro, Jiang Li, Kotani Tomomi, Tsuda Hiroyuki, Mano Yukio, Sumigama Seiji, Hirayama Tasuku, Nagasawa Hideko, Kikkawa Fumitaka, Toyokuni Shinya

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 56 ( 1 ) page: 57 - 63   2015.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3164/jcbn.14-82

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  21. Surgical techniques at caesarean might modify placenta accreta risk Reply

    Sumigama S.

    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 122 ( 1 ) page: 144 - 144   2015.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1471-0528.13203

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  22. Impact of warning bleeding on the cortisol level in the fetus and neonatal RDS/TTN in cases of placenta previa

    Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Hua Li, Kikkawa Fumitaka

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE   Vol. 28 ( 9 ) page: 1057 - 1060   2015

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    DOI: 10.3109/14767058.2014.942632

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  23. Uterine sutures at prior caesarean section and placenta accreta in subsequent pregnancy: a case-control study

    Sumigama S., Sugiyama C., Kotani T., Hayakawa H., Inoue A., Mano Y., Tsuda H., Furuhashi M., Yamamuro O., Kinoshita Y., Okamoto T., Nakamura H., Matsusawa K., Sakakibara K., Oguchi H., Kawai M., Shimoyama Y., Tamakoshi K., Kikkawa F.

    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY   Vol. 121 ( 7 ) page: 866 - 874   2014.6

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1471-0528.12717

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  24. An Antenatal Therapeutic Strategy of Congenital Diaphragmatic Hernia.

    Hirako Shima, Tuda Hiroyuki, Li Hua, Nakano Tomoko, Watanabe Yuriko, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 21 ( 3 ) page: 274A - 274A   2014.3

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  25. The New Insights of Preterm Labor with Chorioamnionitis (CAM)

    Kotani Tomomi, Sumigama Seiji, Tsuda Hiroyuki, Mano Yukio, Nakano Tomoko, Hirako Shima, Li Hua, Kikkawa Fumitaka

    REPRODUCTIVE SCIENCES   Vol. 21 ( 3 ) page: 242A - 242A   2014.3

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  26. Effect of placenta previa on neonatal respiratory disorders and amniotic lamellar body counts at 36-38 weeks of gestation

    Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Hua Li, Hayakawa Hiromi, Hayakawa Masahiro, Sato Yoshiaki, Kikkawa Fumitaka

    EARLY HUMAN DEVELOPMENT   Vol. 90 ( 1 ) page: 51 - 54   2014.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.earlhumdev.2013.10.005

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  27. Uterine sutures at prior caesarean section and placenta accreta in subsequent pregnancy: a case-control study

    Sumigama S, Sugiyama C, Kotani T, et al.

    BJOG : an international journal of obstetrics and gynaecology     page: 866-74   2014

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  28. Altered Expression of Enzymes Regulating the Activity of Endothelin-1 in the Lower Segment of the Human Amnion During Labor

    Kotani Tomomi, Iwase Akira, Tsuda Hiroyuki, Mano Yukio, Yamamoto Eiko, Nakano Tomoko, Hasegawa Yumi, Li Hua, Sumigama Seiji, Itakura Atsuo, Kikkawa Fumitaka

    BIOLOGY OF REPRODUCTION   Vol. 89 ( 3 ) page: 52   2013.9

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1095/biolreprod.113.108480

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  29. Amniotic lamellar body count and congenital diaphragmatic hernia in humans and in a rat model

    Watanabe Yuriko, Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Hayakawa Masahiro, Sato Yoshiaki, Kikkawa Fumitaka

    PEDIATRIC RESEARCH   Vol. 73 ( 3 ) page: 344 - 348   2013.3

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/pr.2012.187

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  30. Increased expression of sphingosine kinase in the amnion during labor

    Erkhembaatar LO, Kotani T, Sumigama S, et al.

    Placenta     page: 353-9   2013

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    . 2013;34:353-9

  31. Mucinous cystic neoplasm of the pancreas with severe dysplasia during pregnancy: Case report and review of the literature

    Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Shimoyama Yoshie, Kikkawa Fumitaka

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   Vol. 51 ( 4 ) page: 635 - 638   2012.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tjog.2012.09.022

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  32. Validity of Lamellar Body Count as a Fetal Lung Maturity Assessment in Twin Pregnancy

    Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Kawabata Ichiro, Takahashi Yuichiro, Iwagaki Shigenori, Kigoshi Kaori, Kikkawa Fumitaka

    TWIN RESEARCH AND HUMAN GENETICS   Vol. 15 ( 4 ) page: 547 - 549   2012.8

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1017/thg.2012.29

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  33. Validity of Lamellar Body Count as a Fetal Lung Maturity Assessment in Twin Pregnancy

    Tsuda H, Kotani T, Sumigama S, et al.

    Twin Research and Human Genetics     page: 547-9   2012

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  34. The Loss of Endoglin Promotes the Invasion of Extravillous Trophoblasts

    Mano Yukio, Kotani Tomomi, Shibata Kiyozumi, Matsumura Hiroko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Iwase Akira, Senga Takeshi, Kikkawa Fumitaka

    ENDOCRINOLOGY   Vol. 152 ( 11 ) page: 4386 - 4394   2011.11

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2011-1088

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  35. Maternal mental disorders and pregnancy outcomes: A clinical study in a Japanese population

    Hironaka Masae, Kotani Tomomi, Sumigama Seiji, Tsuda Hiroyuki, Mano Yukio, Hayakawa Hiromi, Tanaka Satoshi, Ozaki Norio, Tamakoshi Koji, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 37 ( 10 ) page: 1283 - 1289   2011.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1447-0756.2010.01512.x

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  36. Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN)

    Tsuda Hiroyuki, Takahashi Yuichiro, Iwagaki Shigenori, Uchida Yasushi, Kawabata Ichiro, Hayakawa Masahiro, Sumigama Seiji, Hayakawa Hiromi, Kotani Tomomi, Kikkawa Fumitaka

    JOURNAL OF PERINATAL MEDICINE   Vol. 39 ( 3 ) page: 245 - 250   2011.5

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    DOI: 10.1515/JPM.2011.006

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  37. Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment

    Iwase Akira, Goto Maki, Manabe Shuichi, Hirokawa Wakana, Kobayashi Hiroharu, Nakahara Tatsuo, Takikawa Sachiko, Kotani Tomomi, Sumigama Seiji, Tsuda Hiroyuki, Nakayama Takayuki, Suzuki Nobuaki, Matsushita Tadashi, Kikkawa Fumitaka

    FERTILITY AND STERILITY   Vol. 95 ( 6 ) page: 2124.e5 - 7   2011.5

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    DOI: 10.1016/j.fertnstert.2011.01.011

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  38. Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma

    Kotani T., Sumigama S., Hayakawa H., Mano Y., Tsuda H., Sugiyama C., Kawachi F., Hironaka M., Kato T., Kaneko K., Hayakawa M., Kikkawa F.

    ULTRASOUND IN OBSTETRICS & GYNECOLOGY   Vol. 36 ( 2 ) page: 256 - 258   2010.8

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    DOI: 10.1002/uog.7637

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  39. Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma

    Kotani T, Sumigama S, Hayakawa H, et al.

    Ultrasound in Obstetrics & Gynecology     page: 256-8   2010

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  40. Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells

    Morimitsu Akiko, Sumigama Seiji, Kotani Tomomi, Mano Yukio, Suzuki Kanako, Araki-Taguchi Masako, Yamamoto Eiko, Hayakawa Hiromi, Okada Mayumi, Itakura Atsuo, Kikkawa Fumitaka

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 69 ( 1 ) page: 67 - 72   2010

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000257663

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  41. Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line.

    Kotani T, Iwase A, Ino K, Sumigama S, Yamamoto E, Hayakawa H, Nagasaka T, Itakura A, Nomura S, Kikkawa F

    Endocrinology   Vol. 150 ( 9 ) page: 4376 - 85   2009.9

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2008-1645

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  42. N-Acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of alpha 5 beta 1 Integrin

    Yamamoto Eiko, Ino Kazuhiko, Miyoshi Eiji, Inamori Kei-ichiro, Abe Akihiro, Sumigama Seiji, Iwase Akira, Kajiyama Hiroaki, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka

    ENDOCRINOLOGY   Vol. 150 ( 2 ) page: 990 - 999   2009.2

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2008-1005

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  43. Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells

    Morimitsu A, Sumigama S, Kotani T, et al.

    Gynecol Obstet Invest     page: 67-72   2009

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  44. Tocilizumab Inhibits Interleukin-6-Mediated Matrix Metalloproteinase-2 and-9 Secretions from Human Amnion Cells in Preterm Premature Rupture of Membranes

    Mano Yukio, Shibata Kiyosumi, Sumigama Seiji, Hayakawa Hiromi, Ino Kazuhiko, Yamamoto Eiko, Kajiyama Hiroaki, Nawa Akihiro, Kikkawa Fumitaka

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 68 ( 3 ) page: 145 - 153   2009

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    DOI: 10.1159/000229021

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  45. Angiotensin II mimics the hypoxic effect on regulating trophoblast proliferation and differentiation in human placental explant cultures

    Araki-Taguchi Masako, Nomura Seiji, Ino Kazuhiko, Sumigama Seiji, Yamamoto Eiko, Kotani-Ito Tomomi, Hayakawa Hiromi, Kajiyama Hiroaki, Shibata Kiyosumi, Itakura Atsuo, Kikkawa Fumitaka

    LIFE SCIENCES   Vol. 82 ( 1-2 ) page: 59 - 67   2008.1

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    DOI: 10.1016/j.lfs.2007.10.017

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  46. *Placenta previa increta/percreta in Japan - a retrospective study of ultrasound findings, management and clinical course Reviewed

    Seiji Sumigama, Atsuo Itakura, Toyohiro Ota, Mayumi Okada, Tomomi Kotani, Hiromi Hayakawa, Kana Yoshida, Kaoru Ishikawa, Kazumasa Hayashi, Osamu Kurauchi, Satoru Yamada, Hiromi Nakamura, Katsuji Matsusawa, Katsumi Sakakibara, Mitsuaki Ito, Michiyasu Kawai, and Fumitaka Kikkawa

    J Obstet Gynaecol Res   Vol. 33 ( 5 ) page: 606-611   2007.10

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  47. Placenta previa increta/percreta in Japan: A retrospective study of ultrasound findings, management and clinical course

    Sumigama Seiji, Itakura Atsuo, Ota Toyohiro, Okada Mayumi, Kotani Tomomi, Hayakawa Hiromi, Yoshida Kana, Ishikawa Kaoru, Hayashi Kazumasa, Kurauchi Osamu, Yamada Satoru, Nakamura Hiromi, Matsusawa Katsuji, Sakakibara Katsumi, Ito Mitsuaki, Kawai Michiyasu, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 33 ( 5 ) page: 606 - 611   2007.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1447-0756.2007.00619.x

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  48. *Genetically identified complete hydatidiform mole coexisting with a live twin fetus: Comparison with conventional diagnosis. Reviewed

    Seiji Sumigama, Atsuo Itakura, Toshimichi Yamamoto, Tetsuro Nagasaka, Eiko Yamamoto, Kazuhiko Ino and Fumitaka Kikkawa

    Gynecol Obstet Inves   Vol. 30 ( 64(2) ) page: 228-231   2007.7

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  49. The MRI findings of the right-sided fetal lung can be used to predict postnatal mortality and the requirement for extracorporeal membrane oxygenation in isolated left-sided congenital diaphragmatic hernia.

    Hayakawa M, Seo T, Itakua A, Hayashi S, Miyauchi M, Sato Y, Saito A, Nakayama A, Takemoto K, Hasegawa M, Kaneko K, Okada M, Hayakawa H, Sumigama S, Kikkawa F, Ando H, Kojima S

    Pediatric research   Vol. 62 ( 1 ) page: 93 - 7   2007.7

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1203/PDR.0b013e3180676cdb

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  50. A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature

    Yamamoto E., Ino K., Yamamoto T., Sumigama S., Nawa A., Nomura S., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 17 ( 1 ) page: 254 - U1   2007

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1525-1438.2006.00764.x

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  51. Genetically identified complete hydatidiform mole coexisting with a live twin fetus: Comparison with conventional diagnosis

    Sumigama Seiji, Itakura Atsuo, Yamamoto Toshimichi, Nagasaka Tetsuro, Yamamoto Eiko, Ino Kazuhiko, Kikkawa Fumitaka

    GYNECOLOGIC AND OBSTETRIC INVESTIGATION   Vol. 64 ( 4 ) page: 228 - 231   2007

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000106496

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  52. Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells

    Shido F, Ito T, Nomura S, Yamamoto E, Sumigama S, Ino K, Itakura A, Hattori A, Tsujimoto M, Mizutani S, Kikkawa F

    ENDOCRINOLOGY   Vol. 147 ( 4 ) page: 1780 - 1788   2006.4

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/en.2005-1449

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  53. Gene regulation and physiological function of placental leucine arninopeptidase/oxytocinase during pregnancy

    Nomura S, Ito T, Yamamoto E, Sumigama S, Iwase A, Okada M, Shibata K, Ando H, Ino K, Kikkawa F, Mizutani S

    BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS   Vol. 1751 ( 1 ) page: 19 - 25   2005.8

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbapap.2005.04.006

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  54. Ikaros regulates invasiveness of human extravillous trophoblast

    Yamamoto E, Ito T, Shido F, Sumigama S, Nomura S, Kikkawa F

    PLACENTA   Vol. 25 ( 10 ) page: A2 - A2   2004.11

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  55. Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha.

    Sumigama S, Ito T, Kajiyama H, Shibata K, Tamakoshi K, Kikkawa F, Williams T, Tainsky MA, Nomura S, Mizutani S

    Oncogene   Vol. 23 ( 32 ) page: 5496 - 504   2004.7

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.onc.1207723

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  56. *Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha Reviewed

    Seiji Sumigama, Tomomi Ito, Hiroaki Kajiyama, Kiyosumi Shibata, Koji Tamakoshi, Fumitaka Kikkawa, Trevor Williams, Michael A. Tainsky, Seiji Nomura, Shigehiko Mizutani

    Oncogene   Vol. 23   page: 5496-5504   2004.7

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  57. Insulin stimulates placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase expression in BeWo choriocarcinoma cells

    Nakata M, Nomura S, Ikomo Y, Sumigama S, Shido F, Ito T, Okada M, Kikkawa F, Tsujimoto M, Mizutani S

    REGULATORY PEPTIDES   Vol. 117 ( 3 ) page: 187 - 193   2004.3

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.regpep.2003.10.015

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Books 2

  1. *特集 前置癒着胎盤:臨床経験に学ぶ 各施設における臨床経験と前置癒着胎盤の取り扱い 名古屋大学における取り扱い(2007)

    炭竈誠二、早川博生、吉川史隆( Role: Joint author)

    金原出版  2008 

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    Language:Japanese

  2. 周産期学シンポジウムNo.25/前置癒着胎盤の実態調査と自己血貯血を併用した二期的手術に関して

    炭竈誠二、早川博生、岡田真由美、板倉敦夫 (日本周産期・新生児医学会周産期シンポジウム運営委員会/企画・編集)( Role: Joint author)

    メジカルビュー社  2007.9 

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    Language:Japanese

Presentations 7

  1. シンポジウム「癒着胎盤の基礎と臨床」癒着胎盤における遺伝子発現解析と 新規血清マーカーの可能性

    炭竈誠二

    第23回 日本胎盤学会学術集会 

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    Event date: 2015.11.6

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Country:Japan  

  2. 教育セミナー 美しい創癒合のために 子宮筋層マーキング法の有用性

    炭竈誠二

    第51回 日本周産期新生児医学会 

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    Event date: 2015.7.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  3. スポンサードレクチャー 癒着胎盤の子宮全摘〜画像診断に基づいて〜

    炭竈誠二

    第21回 日本胎盤学会学術集会 

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    Event date: 2013.10.26

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  4. 教育セミナー 今こそ再考!次回妊娠時の安全を考えた帝王切開

    炭竈誠二

    第47回 日本周産期・新生児医学会 

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    Event date: 2012.7.8 - 2012.7.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  5. 前置癒着胎盤の病理学的検討~子宮筋層の部位と癒着の有無・程度について~

    第62回日本産科婦人科学会学術講演会 

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    Event date: 2010.4.25

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  6. シンポジウム「産科出血と胎盤異常」前置癒着胎盤の実態と当院における治療の変遷

    炭竈誠二

    第61回 日本産科婦人科学会学術集会 

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    Event date: 2009.4.4

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  7. ワークショップ 名古屋大学における癒着胎盤の実態

    炭竈誠二、早川博生、川地史高、真野由紀雄、森光明子、吉川史隆

    第44回 日本周産期・新生児医学会 

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    Event date: 2008.7.15

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

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KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. ベトナムにおける妊産婦管理および婦人科rare tumorの学際的研究

    2015.04 - Now

    科学研究費補助金  基盤研究(A)

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    Authorship:Coinvestigator(s) 

  2. Interdisciplinary study of obstetric management and gynecological rare tumor in Vietnam

    Grant number:15H02660  2015.04 - 2020.03

    FUMITAKA KIKKAWA

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    For the purpose of not only the development of obstetrics and gynecology in Vietnam, but also creation of evidence worldwide and building of medical research resources to Japan, we investigated obstetric management and gynecological rare tumor in Vietnam at several facilities in Vietnam. In the present study, several findings, which are related to improvement of mothers and children's prognosis,were gained. First, Pregnancy with dengue fever causes thrombocytopenia, which is at risk of postpartum hemorrhage. Second, cesarean section scar pregnancy with an increase in cesarean section rate in Vietnam, could be managed by medication for only selected patients. Third, evaluation of cardiac function by ultrasound examination for fetal growth restriction would be beneficial. Lastly, we found that there was a high secondary rate after molar pregnancy in Vietnam and preventive measures might improve it.

  3. 分子レベルでの癒着胎盤の病態解明と新規バイオマーカー診断法の開発

    2012.04 - 2016.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  4. PATHOLOGICAL INVESTIGATION OF PLACENTA PREVIA ACCRETA: THE SITE OF UTERINE WALL AND THE WIDTH/DEPTH OF VILLOUS INVASION

    Grant number:24791699  2012.04 - 2016.03

    SUMIGAMA SEIJI

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    The objective of the current study is to examine molecular biological change of trophoblast invasion in placenta accreta by DNA microarray analysis. We isolated villous trophoblast from invasive site and control from non-invasive site in a case of placenta accreta and extracted complemantary DNA by RT-PCR. A DNA microarray analysis and Gene ontology analysis extracted overexpressed genes, MMP-19, ADAM-28, cathepsin S and cathepsin L. Immunohistochemistry of accreta cases revealed poor expression of MMP-19 and no difference between invasion and non-invasion site in ADAM-28 and cathepsin S, however a abundant expression of cathepsin L in especially in extra-villous trophoblast in invasion site. The serum cathepsin L level in placenta previa with accreta was significantly higher than those of normal pregnancy and placenta previa with no accreta. Thus, our data suggests a role for cathepsin L in the regulation of abnormal invasion of trophoblast in case of placenta accreta.

  5. 前置癒着胎盤の病態解明と予知について

    2007.04 - 2009.03

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  6. To establish the prediction and to elucidate the pathophysiology of placenta previa accereta

    Grant number:19591909  2007 - 2008

    ITAKURA Atsuo

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    Authorship:Coinvestigator(s) 

  7. 転写因子AP-2による卵巣癌の抗癌剤耐性克服メカニズム及び遺伝子治療への展開

    2005.04 - 2008.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  8. 転写因子AP-2による卵巣癌の抗癌剤耐性克服メカニズム及び遺伝子治療への展開

    Grant number:17791115  2005 - 2007

    炭竈 誠二

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    Authorship:Principal investigator 

    Grant amount:\3500000 ( Direct Cost: \3500000 )

    ・AP-2α遺伝子導入卵巣癌細胞における抗癌剤感受性の変化に関する検討
    AP-2αを強制発現させた卵巣癌細胞株SKOV3においてタキソール・カルボプラチン・シスプラチン・ドキソルビシン・5FUへの感受性がそれぞれ1.26〜2.05倍に亢進していた。その機序として薬剤耐性受容体の発現変化の有無を検討した。ABCB1、ABCC1、ABCC2、ABCG2各受容体についてrealtime RT-PCRを行ったところ、AP-2α強制発現株において各受容体発現は0.92倍、1.09倍、1.12倍、0.89倍、1.21倍であり、有意な変化を示さなかった。また、SKOV3親株とmock株、AP-2α強制発現株においてp53のリン酸化につきWestern blottingにて検討したところ、AP-2α強制発現株においてリン酸化の亢進を認めた。
    実験動物を用いたAP-2α遺伝子導入卵巣癌細胞株の病態と抗癌剤感受性
    ・AP-2α遺伝子導入細胞と親株をヌードマウスの大腿部皮下に接種し、生じる皮下腫瘍の大きさを経時的に計測した。接種3週後における腫瘍サイズは親株において平均80.5mm^3であったのに対しAP-2遺伝子導入細胞においては平均48.6mm^3であった。また、マウスの腹腔内にtaxo1を200μg投与した場合の腫瘍サイズは前者にて平均54.4mm^3であったのに対し後者では8.lmm^3と著明な増殖抑制効果を得た。これらより、AP-2α遺伝子導入によりin vivoにおいても腫瘍増殖抑制効果を、かつtaxolに対する感受性亢進効果を確認した。

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