Organization
Graduate School of Medicine International Collaborative Program in Comprehensive Medical Science between Nagoya University and Lund University Designated lecturer
Title
Designated lecturer
SUMIGAMA, Seiji
Degree 1
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医学博士 （ 2006.3 名古屋大学 ）
Research Areas 2
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Others / Others / Obstetrics and Gynecology
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Life Science / Medical management and medical sociology / 国際医学教育
Research History 3
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Nagoya University
2007.4
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大垣市民病院 産婦人科医員
2000.4 - 2002.3
Country：Japan
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社会保険中京病院 臨床研修医
1998.4 - 2000.3
Country：Japan
Education 2
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Nagoya University Graduate School, Division of Medical Sciences
2003.4 - 2006.3
Country： Japan
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Nagoya University Faculty of Medicine
1992.4 - 1998.3
Country： Japan
Professional Memberships 5
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日本産科婦人科学会
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日本周産期・新生児医学会
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日本胎盤学会
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New European Surgical Academy (NESA)
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International Society of Clinical Medicine
Committee Memberships 4
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日本胎盤学会 評議員
2017.4
Committee type：Academic society
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愛知県母子保健運営協議会 委員
2015.8
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愛知県産婦人科医会 評議員
2015.6 - 2016.5
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Journal of Obstetrics and Gynaecology Research (JOGR) Associate Editor
2013.11
Committee type：Academic society
Awards 2
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第62回日本産科婦人科学会学術講演会 グッドプレゼンテーション賞
2010.4 日本産科婦人科学会
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尚和会学術奨励賞
2008.12 尚和会学術振興基金
Papers 61
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Stepwise Treatment for Abnormally Invasive Placenta with Placenta Previa Invited
Sumigama Seiji, Kotani Tomomi, Hayakawa Hiromi
SURGERY JOURNAL 2021.9
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Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders Reviewed
Matsukawa Satoshi, Sumigama Seiji, Kotani Tomomi, Wang Jingwen, Miki Rika, Moriyama Yoshinori, Nakano Tomoko, Mano Yukio, Tsuda Hiroyuki, Tamakoshi Koji, Kikkawa Fumitaka
GYNECOLOGIC AND OBSTETRIC INVESTIGATION Vol. 84 ( 4 ) page： 396 - 406 2019
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Uterine sutures at prior caesarean section and placenta accreta in subsequent pregnancy: a case-control study Reviewed
Sumigama S., Sugiyama C., Kotani T., Hayakawa H., Inoue A., Mano Y., Tsuda H., Furuhashi M., Yamamuro O., Kinoshita Y., Okamoto T., Nakamura H., Matsusawa K., Sakakibara K., Oguchi H., Kawai M., Shimoyama Y., Tamakoshi K., Kikkawa F.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 121 ( 7 ) page： 866 - 874 2014.6
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*Placenta previa increta/percreta in Japan - a retrospective study of ultrasound findings, management and clinical course Reviewed
Seiji Sumigama, Atsuo Itakura, Toyohiro Ota, Mayumi Okada, Tomomi Kotani, Hiromi Hayakawa, Kana Yoshida, Kaoru Ishikawa, Kazumasa Hayashi, Osamu Kurauchi, Satoru Yamada, Hiromi Nakamura, Katsuji Matsusawa, Katsumi Sakakibara, Mitsuaki Ito, Michiyasu Kawai, and Fumitaka Kikkawa
J Obstet Gynaecol Res Vol. 33 ( 5 ) page： 606－611 2007.10
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*Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha Reviewed
Seiji Sumigama, Tomomi Ito, Hiroaki Kajiyama, Kiyosumi Shibata, Koji Tamakoshi, Fumitaka Kikkawa, Trevor Williams, Michael A. Tainsky, Seiji Nomura, Shigehiko Mizutani
Oncogene Vol. 23 page： 5496-5504 2004.7
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Assessment of myocardial performance index in late-onset fetal growth restriction Reviewed
Tran Thao Nguyen Nguyen, Kotani Tomomi, Imai Kenji, Ushida Takafumi, Moriyama Yoshinori, Kobayashi Tomoko, Niimi Kaoru, Sumigama Seiji, Yamamoto Eiko, Van Duc Vo, Minh Tam Le, Lam Huong Le, Dac Nguyen Nguyen, Vu Quoc Huy Nguyen, Quang Vinh Truong, Ngoc Thanh Cao, Kikkawa Fumitaka
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 83 ( 2 ) page： 259 - 268 2021.5
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Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia Reviewed
Ito Yumiko, Tsuda Hiroyuki, Imai Kenji, Miki Rika, Miura Mayo, Tachi Asuka, Tano Sho, Hirako-Takamura Shima, Moriyama Yoshinori, Ushida Takafumi, Kobayashi Tomoko, Sumigama Seiji, Kajiyama Hiroaki, Kikkawa Fumitaka, Kotani Tomomi
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Vol. 700 page： 108769 2021.3
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Real prevalence of neural tube defects in Japan: How many of such pregnancies have been terminated?
Kondo Atsuo, Akada Shinobu, Akiyama Kunihisa, Arakawa Masato, Ichi Shunsuke, Inamoto Yutaka, Ishida Tomohiko, Ishikawa Hiroshi, Itoh Tomonori, Izumi Akio, Kinnura Fuminori, Kondo Atsuya S., Matsuoka Ryu, Miyauchi Akito, Mochizuki Junko, Monnohara Yoshihito, Morikawa Shigehiko, Morioka Miki, Morota Nobuhito, Nakabe Ken, Obayashi Satoshi, Oku Masataka, Samura Osamu, Sasahara Jun, Sase Masakatsu, Shimamoto Kumi, Shimamura Katsunori, Sumigama Seiji, Tada Katsuhiko, Takahashi Hiroyuki, Tani Akihiro, Wada Seiji, Wada-Hlraike Osamu, Watanabe Tomoyuki, Yamaguchi Masatoshi, Yasui Tomoyo, Yokomine Masato
CONGENITAL ANOMALIES Vol. 59 ( 4 ) page： 118 - 124 2019.7
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Joint Degree Program for Graduate Students at the Nagoya University Graduate School of Medicine
Kasuya Hideki, Aleksic Branko, Sumigama Seiji, Bustos Itzel, Hasegawa Hitoki, Kasai Mika P., Kobayashi Miho, Samizo Yumiko
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 2 ) page： 183 - 192 2019.5
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The role of E2F8 in the human placenta
Mizuno Masako, Miki Rika, Moriyama Yoshinori, Ushida Takafumi, Imai Kenji, Niimi Kaoru, Nakano Tomoko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Senga Takeshi, Iwase Akira, Kikkawa Fumitaka, Kotani Tomomi
MOLECULAR MEDICINE REPORTS Vol. 19 ( 1 ) page： 293-301 2019.1
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A rare pseudo tumour in the extraembryonic coelom in first trimester of pregnancy: ultrasound and pathology
Sumigama Seiji, Enomoto Atsushi, Matsukawa Satoshi, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka
JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 39 ( 4 ) page： 545 - 546 2019
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The Current Status and Future Prospects of Oncolytic Viruses in Clinical Trials against Melanoma, Glioma, Pancreatic, and Breast Cancers
Eissa Ibrahim Ragab, Bustos-Villalobos Itzel, Ichinose Toru, Matsumura Shigeru, Naoe Yoshinori, Miyajima Noriyuki, Morimoto Daishi, Mukoyama Nobuaki, Wu Zhiwen, Tanaka Maki, Hasegawa Hitoki, Sumigama Seiji, Aleksic Branko, Kodera Yasuhiro, Kasuya Hideki
CANCERS Vol. 10 ( 10 ) 2018.10
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PLACENTAL PROTEOMIC ANALYSIS OF PLACENTA ACCRETA
Moriyama Yoshinori, Sumigama Seiji, Mizutani Teruyuki, Nomoto Masataka, Ushida Takafumi, Imai Kenji, Nakano Tomoko, Kotani Tomomi, Kikkawa Fumitaka
PLACENTA Vol. 69 page： E74-E75 2018.9
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The expression of Toll-like receptor 5 in preterm histologic chorioamnionitis.
Moroi H, Kotani T, Miki R, Tsuda H, Mizuno M, Ito Y, Ushida T, Imai K, Nakano T, Li H, Sumigama S, Yamamoto E, Iwase A, Kikkawa F
Journal of clinical biochemistry and nutrition Vol. 62 ( 1 ) page： 63-67 2018.1
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Association of serum asymmetric dimethylarginine, homocysteine, and L-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy
Maruta Ei, Wang Jingwen, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Imai Kenji, Sumigama Seiji, Niwa Yoshimitsu, Mitsui Takashi, Yoshida Shigeru, Yamashita Mamoru, Nawa Akihiro, Tamakoshi Koji, Kajiyama Hiroaki, Kikkawa Fumitaka
CLINICA CHIMICA ACTA Vol. 475 page： 70-77 2017.12
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Genomic Signature of the Natural Oncolytic Herpes Simplex Virus HF10 and Its Therapeutic Role in Preclinical and Clinical Trials.
Eissa IR, Naoe Y, Bustos-Villalobos I, Ichinose T, Tanaka M, Zhiwen W, Mukoyama N, Morimoto T, Miyajima N, Hitoki H, Sumigama S, Aleksic B, Kodera Y, Kasuya H
Frontiers in oncology Vol. 7 page： 149 2017
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Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia
Hirako Shima, Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Nakano Tomoko, Imai Kenji, Li Hua, Toyokuni Shinya, Kikkawa Fumitaka
PHYTOTHERAPY RESEARCH Vol. 30 ( 9 ) page： 1474 - 1480 2016.9
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Efficacy and safety of daikenchuto (TJ-100) in pregnant women with constipation
Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Hayakawa Hiromi, Kikkawa Fumitaka
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY Vol. 55 ( 1 ) page： 26 - 29 2016.2
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Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia
Imai Kenji, Kotani Tomomi, Tsuda Hiroyuki, Mano Yukio, Nakano Tomoko, Ushida Takafumi, Li Hua, Miki Rika, Sumigama Seiji, Iwase Akira, Hirakawa Akihiro, Ohno Kinji, Toyokuni Shinya, Takeuchi Hideyuki, Mizuno Tetsuya, Suzumura Akio, Kikkawa Fumitaka
FREE RADICAL BIOLOGY AND MEDICINE Vol. 91 page： 154 - 163 2016.2
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Relationship between the cortisol levels in umbilical cord blood and neonatal RDS/TTN in twin pregnancies
Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Nakano Tomoko, Hua Li, Kikkawa Fumitaka
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE Vol. 29 ( 13 ) page： 2151 - 2156 2016
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Risk assessment for neonatal RDS/TTN using gestational age and the amniotic lamellar body count in twin pregnancies
Tsuda Hiroyuki, Hirakawa Akihiro, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Nakano Tomoko, Imai Kenji, Kawabata Ichiro, Takahashi Yuichiro, Iwagaki Shigenori, Kikkawa Fumitaka
CLINICA CHIMICA ACTA Vol. 451 ( Pt B ) page： 301 - 304 2015.12
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Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury
Nakano Tomoko, Kotani Tomomi, Mano Yukio, Tsuda Hiroyuki, Imai Kenji, Ushida Takafumi, Li Hua, Miki Rika, Sumigama Seiji, Sato Yoshiaki, Iwase Akira, Hirakawa Akihiro, Asai Masato, Toyokuni Shinya, Kikkawa Fumitaka
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION Vol. 57 ( 3 ) page： 178 - 182 2015.11
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Is the serum L-arginine level during early pregnancy a predictor of pregnancy-induced hypertension?
Wang Jingwen, Kotani Tomomi, Tsuda Hiroyuki, Mano Yukio, Sumigama Seiji, Li Hua, Komatsu Koji, Miki Rika, Maruta Ei, Niwa Yoshimitsu, Mitsui Takashi, Yoshida Shigeru, Yamashita Mamoru, Tamakoshi Koji, Kikkawa Fumitaka
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION Vol. 57 ( 1 ) page： 74 - 81 2015.7
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Amniotic lamellar body count: predicting and distinguishing neonatal respiratory complications in twin pregnancies
Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Kawabata Ichiro, Takahashi Yuichiro, Iwagaki Shigenori, Hirakawa Akihiro, Kikkawa Fumitaka
CLINICA CHIMICA ACTA Vol. 441 page： 75 - 78 2015.2
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Catalytic ferrous iron in amniotic fluid as a predictive marker of human maternal-fetal disorders
Hattori Yuka, Mukaide Takahiro, Jiang Li, Kotani Tomomi, Tsuda Hiroyuki, Mano Yukio, Sumigama Seiji, Hirayama Tasuku, Nagasawa Hideko, Kikkawa Fumitaka, Toyokuni Shinya
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION Vol. 56 ( 1 ) page： 57 - 63 2015.1
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Surgical techniques at caesarean might modify placenta accreta risk Reply
Sumigama S.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY Vol. 122 ( 1 ) page： 144 - 144 2015.1
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Impact of warning bleeding on the cortisol level in the fetus and neonatal RDS/TTN in cases of placenta previa
Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Hua Li, Kikkawa Fumitaka
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE Vol. 28 ( 9 ) page： 1057 - 1060 2015
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Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury
Hattori Y., Kotani T., Tsuda H., Mano Y., Tu L., Li H., Hirako S., Ushida T., Imai K., Nakano T., Sato Y., Miki R., Sumigama S., Iwase A., Toyokuni S., Kikkawa F.
FREE RADICAL RESEARCH Vol. 49 ( 8 ) page： 1026 - 1037 2015
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An Antenatal Therapeutic Strategy of Congenital Diaphragmatic Hernia.
Hirako Shima, Tuda Hiroyuki, Li Hua, Nakano Tomoko, Watanabe Yuriko, Sumigama Seiji, Kotani Tomomi, Kikkawa Fumitaka
REPRODUCTIVE SCIENCES Vol. 21 ( 3 ) page： 274A - 274A 2014.3
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The New Insights of Preterm Labor with Chorioamnionitis (CAM)
Kotani Tomomi, Sumigama Seiji, Tsuda Hiroyuki, Mano Yukio, Nakano Tomoko, Hirako Shima, Li Hua, Kikkawa Fumitaka
REPRODUCTIVE SCIENCES Vol. 21 ( 3 ) page： 242A - 242A 2014.3
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Effect of placenta previa on neonatal respiratory disorders and amniotic lamellar body counts at 36-38 weeks of gestation
Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Hua Li, Hayakawa Hiromi, Hayakawa Masahiro, Sato Yoshiaki, Kikkawa Fumitaka
EARLY HUMAN DEVELOPMENT Vol. 90 ( 1 ) page： 51 - 54 2014.1
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Uterine sutures at prior caesarean section and placenta accreta in subsequent pregnancy: a case-control study
Sumigama S, Sugiyama C, Kotani T, et al.
BJOG : an international journal of obstetrics and gynaecology page： 866-74 2014
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Altered Expression of Enzymes Regulating the Activity of Endothelin-1 in the Lower Segment of the Human Amnion During Labor
Kotani Tomomi, Iwase Akira, Tsuda Hiroyuki, Mano Yukio, Yamamoto Eiko, Nakano Tomoko, Hasegawa Yumi, Li Hua, Sumigama Seiji, Itakura Atsuo, Kikkawa Fumitaka
BIOLOGY OF REPRODUCTION Vol. 89 ( 3 ) page： 52 2013.9
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Amniotic lamellar body count and congenital diaphragmatic hernia in humans and in a rat model
Watanabe Yuriko, Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Hayakawa Masahiro, Sato Yoshiaki, Kikkawa Fumitaka
PEDIATRIC RESEARCH Vol. 73 ( 3 ) page： 344 - 348 2013.3
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Increased expression of sphingosine kinase in the amnion during labor
Erkhembaatar LO, Kotani T, Sumigama S, et al.
Placenta page： 353-9 2013
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Mucinous cystic neoplasm of the pancreas with severe dysplasia during pregnancy: Case report and review of the literature
Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Mano Yukio, Shimoyama Yoshie, Kikkawa Fumitaka
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY Vol. 51 ( 4 ) page： 635 - 638 2012.12
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Validity of Lamellar Body Count as a Fetal Lung Maturity Assessment in Twin Pregnancy
Tsuda Hiroyuki, Kotani Tomomi, Sumigama Seiji, Kawabata Ichiro, Takahashi Yuichiro, Iwagaki Shigenori, Kigoshi Kaori, Kikkawa Fumitaka
TWIN RESEARCH AND HUMAN GENETICS Vol. 15 ( 4 ) page： 547 - 549 2012.8
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Validity of Lamellar Body Count as a Fetal Lung Maturity Assessment in Twin Pregnancy
Tsuda H, Kotani T, Sumigama S, et al.
Twin Research and Human Genetics page： 547-9 2012
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The Loss of Endoglin Promotes the Invasion of Extravillous Trophoblasts
Mano Yukio, Kotani Tomomi, Shibata Kiyozumi, Matsumura Hiroko, Tsuda Hiroyuki, Sumigama Seiji, Yamamoto Eiko, Iwase Akira, Senga Takeshi, Kikkawa Fumitaka
ENDOCRINOLOGY Vol. 152 ( 11 ) page： 4386 - 4394 2011.11
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Maternal mental disorders and pregnancy outcomes: A clinical study in a Japanese population
Hironaka Masae, Kotani Tomomi, Sumigama Seiji, Tsuda Hiroyuki, Mano Yukio, Hayakawa Hiromi, Tanaka Satoshi, Ozaki Norio, Tamakoshi Koji, Kikkawa Fumitaka
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Vol. 37 ( 10 ) page： 1283 - 1289 2011.10
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Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN)
Tsuda Hiroyuki, Takahashi Yuichiro, Iwagaki Shigenori, Uchida Yasushi, Kawabata Ichiro, Hayakawa Masahiro, Sumigama Seiji, Hayakawa Hiromi, Kotani Tomomi, Kikkawa Fumitaka
JOURNAL OF PERINATAL MEDICINE Vol. 39 ( 3 ) page： 245 - 250 2011.5
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Successful fertility management of a patient with factor V deficiency: planned transfusion of fresh frozen plasma under infertility treatment
Iwase Akira, Goto Maki, Manabe Shuichi, Hirokawa Wakana, Kobayashi Hiroharu, Nakahara Tatsuo, Takikawa Sachiko, Kotani Tomomi, Sumigama Seiji, Tsuda Hiroyuki, Nakayama Takayuki, Suzuki Nobuaki, Matsushita Tadashi, Kikkawa Fumitaka
FERTILITY AND STERILITY Vol. 95 ( 6 ) page： 2124.e5 - 7 2011.5
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Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma
Kotani T., Sumigama S., Hayakawa H., Mano Y., Tsuda H., Sugiyama C., Kawachi F., Hironaka M., Kato T., Kaneko K., Hayakawa M., Kikkawa F.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY Vol. 36 ( 2 ) page： 256 - 258 2010.8
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Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma
Kotani T, Sumigama S, Hayakawa H, et al.
Ultrasound in Obstetrics & Gynecology page： 256-8 2010
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Histamine Stimulates Interleukin-6 Production through Histamine H1 Receptors in Human Amnion Cells
Morimitsu Akiko, Sumigama Seiji, Kotani Tomomi, Mano Yukio, Suzuki Kanako, Araki-Taguchi Masako, Yamamoto Eiko, Hayakawa Hiromi, Okada Mayumi, Itakura Atsuo, Kikkawa Fumitaka
GYNECOLOGIC AND OBSTETRIC INVESTIGATION Vol. 69 ( 1 ) page： 67 - 72 2010
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Activator protein-2 impairs the invasion of a human extravillous trophoblast cell line.
Kotani T, Iwase A, Ino K, Sumigama S, Yamamoto E, Hayakawa H, Nagasaka T, Itakura A, Nomura S, Kikkawa F
Endocrinology Vol. 150 ( 9 ) page： 4376 - 85 2009.9
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N-Acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of alpha 5 beta 1 Integrin
Yamamoto Eiko, Ino Kazuhiko, Miyoshi Eiji, Inamori Kei-ichiro, Abe Akihiro, Sumigama Seiji, Iwase Akira, Kajiyama Hiroaki, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka
ENDOCRINOLOGY Vol. 150 ( 2 ) page： 990 - 999 2009.2
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Histamine stimulates interleukin-6 production through histamine H1 receptors in human amnion cells
Morimitsu A, Sumigama S, Kotani T, et al.
Gynecol Obstet Invest page： 67-72 2009
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Tocilizumab Inhibits Interleukin-6-Mediated Matrix Metalloproteinase-2 and-9 Secretions from Human Amnion Cells in Preterm Premature Rupture of Membranes
Mano Yukio, Shibata Kiyosumi, Sumigama Seiji, Hayakawa Hiromi, Ino Kazuhiko, Yamamoto Eiko, Kajiyama Hiroaki, Nawa Akihiro, Kikkawa Fumitaka
GYNECOLOGIC AND OBSTETRIC INVESTIGATION Vol. 68 ( 3 ) page： 145 - 153 2009
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Angiotensin II mimics the hypoxic effect on regulating trophoblast proliferation and differentiation in human placental explant cultures
Araki-Taguchi Masako, Nomura Seiji, Ino Kazuhiko, Sumigama Seiji, Yamamoto Eiko, Kotani-Ito Tomomi, Hayakawa Hiromi, Kajiyama Hiroaki, Shibata Kiyosumi, Itakura Atsuo, Kikkawa Fumitaka
LIFE SCIENCES Vol. 82 ( 1-2 ) page： 59 - 67 2008.1
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Placenta previa increta/percreta in Japan: A retrospective study of ultrasound findings, management and clinical course
Sumigama Seiji, Itakura Atsuo, Ota Toyohiro, Okada Mayumi, Kotani Tomomi, Hayakawa Hiromi, Yoshida Kana, Ishikawa Kaoru, Hayashi Kazumasa, Kurauchi Osamu, Yamada Satoru, Nakamura Hiromi, Matsusawa Katsuji, Sakakibara Katsumi, Ito Mitsuaki, Kawai Michiyasu, Kikkawa Fumitaka
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Vol. 33 ( 5 ) page： 606 - 611 2007.10
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*Genetically identified complete hydatidiform mole coexisting with a live twin fetus: Comparison with conventional diagnosis. Reviewed
Seiji Sumigama, Atsuo Itakura, Toshimichi Yamamoto, Tetsuro Nagasaka, Eiko Yamamoto, Kazuhiko Ino and Fumitaka Kikkawa
Gynecol Obstet Inves Vol. 30 ( 64(2) ) page： 228-231 2007.7
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The MRI findings of the right-sided fetal lung can be used to predict postnatal mortality and the requirement for extracorporeal membrane oxygenation in isolated left-sided congenital diaphragmatic hernia.
Hayakawa M, Seo T, Itakua A, Hayashi S, Miyauchi M, Sato Y, Saito A, Nakayama A, Takemoto K, Hasegawa M, Kaneko K, Okada M, Hayakawa H, Sumigama S, Kikkawa F, Ando H, Kojima S
Pediatric research Vol. 62 ( 1 ) page： 93 - 7 2007.7
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The MRI findings of the right-sided fetal lung can be used to predict postnatal mortality and the requirement for extracorporeal membrane oxygenation in isolated left-sided congenital diaphragmatic hernia
Hayakawa Masahiro, Seo Takahiko, Itakua Atsuo, Hayashi Seiji, Miyauchi Megumi, Sato Yoshiaki, Saito Akiko, Nakayama Atsushi, Takemoto Koji, Hasegawa Masayuki, Kaneko Kenitiro, Okada Mayumi, Hayakawa Hiromi, Sumigama Seiji, Kikkawa Fumitaka, Ando Hisami, Kojima Seiji
PEDIATRIC RESEARCH Vol. 62 ( 1 ) page： 93 - 97 2007.7
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A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature
Yamamoto E., Ino K., Yamamoto T., Sumigama S., Nawa A., Nomura S., Kikkawa F.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER Vol. 17 ( 1 ) page： 254 - U1 2007
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Genetically identified complete hydatidiform mole coexisting with a live twin fetus: Comparison with conventional diagnosis
Sumigama Seiji, Itakura Atsuo, Yamamoto Toshimichi, Nagasaka Tetsuro, Yamamoto Eiko, Ino Kazuhiko, Kikkawa Fumitaka
GYNECOLOGIC AND OBSTETRIC INVESTIGATION Vol. 64 ( 4 ) page： 228 - 231 2007
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Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells
Shido F, Ito T, Nomura S, Yamamoto E, Sumigama S, Ino K, Itakura A, Hattori A, Tsujimoto M, Mizutani S, Kikkawa F
ENDOCRINOLOGY Vol. 147 ( 4 ) page： 1780 - 1788 2006.4
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Gene regulation and physiological function of placental leucine arninopeptidase/oxytocinase during pregnancy
Nomura S, Ito T, Yamamoto E, Sumigama S, Iwase A, Okada M, Shibata K, Ando H, Ino K, Kikkawa F, Mizutani S
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS Vol. 1751 ( 1 ) page： 19 - 25 2005.8
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Ikaros regulates invasiveness of human extravillous trophoblast
Yamamoto E, Ito T, Shido F, Sumigama S, Nomura S, Kikkawa F
PLACENTA Vol. 25 ( 10 ) page： A2 - A2 2004.11
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Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha.
Sumigama S, Ito T, Kajiyama H, Shibata K, Tamakoshi K, Kikkawa F, Williams T, Tainsky MA, Nomura S, Mizutani S
Oncogene Vol. 23 ( 32 ) page： 5496 - 504 2004.7
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Insulin stimulates placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase expression in BeWo choriocarcinoma cells
Nakata M, Nomura S, Ikomo Y, Sumigama S, Shido F, Ito T, Okada M, Kikkawa F, Tsujimoto M, Mizutani S
REGULATORY PEPTIDES Vol. 117 ( 3 ) page： 187 - 193 2004.3
Books 14
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産科婦人科臨床シリーズ 3．分娩・産褥期の正常と異常/周産期感染症 3章 分娩の異常 前置胎盤・癒着胎盤
炭竈誠二（ Role： Contributor）
中山書店 2021.4
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今日の疾患辞典 異所性妊娠、流産・切迫早産
炭竈誠二（ Role： Contributor）
プレシジョン 2020.1
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基礎と臨床の両側面からみた胎盤学 妊娠中の胎盤診断 MRI
炭竈誠二（ Role： Contributor）
日本胎盤学会 2019.12
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【既往帝王切開後の合併症】既往帝王切開と癒着胎盤について
炭竈誠二、小谷友美、今井健史、中野知子、津田弘之、吉川史隆（ Role： Joint author）
金原出版 2017.2
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【現代帝王切開学】 母性の立場から 帝王切開術式の工夫 子宮筋層縫合法
炭竈 誠二, 今井 健史, 中野 知子, 津田 弘之, 小谷 友美（ Role： Joint author）
東京医学社 2016.9
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産婦人科処方実践マニュアル 妊娠中の産科異常 前置胎盤
炭竈誠二（ Role： Contributor）
診断と治療社 2016.3
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産科診療Q&A 一つ上を行く診療の実践 帝切既往前置胎盤
炭竈誠二（ Role： Contributor）
中外医学社 2015.4
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【よくわかる検査と診断】(第1章)周産期分野 分娩時の異常 癒着胎盤
炭竈誠二（ Role： Contributor）
診断と治療社 2015.3
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周産期の画像診断 「前置胎盤・癒着胎盤」
炭竈誠二（ Role： Contributor）
東京医学社 2013
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帝王切開後の子宮前壁楔状欠損と筋層菲薄化に関する検討
炭竈誠二、吉川史隆（ Role： Joint author）
金原出版 2013
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【産婦人科救急のすべて】 産科救急の診療 癒着胎盤とその管理
炭竈誠二、吉川史隆（ Role： Contributor）
永井書店 2010
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周産期診療指針2010 産科編 異常分娩と分娩時偶発症(合併症)への対応 子宮破裂/弛緩出血
炭竈誠二（ Role： Contributor）
東京医学社 2010
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特集 前置癒着胎盤：臨床経験に学ぶ 各施設における臨床経験と前置癒着胎盤の取り扱い 名古屋大学における取り扱い（2007）
炭竈誠二、早川博生、吉川史隆（ Role： Joint author）
金原出版 2008
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周産期学シンポジウムNo.25 前置癒着胎盤の実態調査と自己血貯血を併用した二期的手術に関して
炭竈誠二、早川博生、岡田真由美、板倉敦夫 (日本周産期・新生児医学会周産期シンポジウム運営委員会/企画・編集)（ Role： Joint author）
メジカルビュー社 2007.9
Presentations 7
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シンポジウム「癒着胎盤の基礎と臨床」癒着胎盤における遺伝子発現解析と 新規血清マーカーの可能性
炭竈誠二
第23回 日本胎盤学会学術集会
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教育セミナー 美しい創癒合のために 子宮筋層マーキング法の有用性
炭竈誠二
第51回 日本周産期新生児医学会
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スポンサードレクチャー 癒着胎盤の子宮全摘〜画像診断に基づいて〜
炭竈誠二
第21回 日本胎盤学会学術集会
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教育セミナー 今こそ再考！次回妊娠時の安全を考えた帝王切開
炭竈誠二
第47回 日本周産期・新生児医学会
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前置癒着胎盤の病理学的検討～子宮筋層の部位と癒着の有無・程度について～
第62回日本産科婦人科学会学術講演会
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シンポジウム「産科出血と胎盤異常」前置癒着胎盤の実態と当院における治療の変遷
炭竈誠二
第61回 日本産科婦人科学会学術集会
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ワークショップ 名古屋大学における癒着胎盤の実態
炭竈誠二、早川博生、川地史高、真野由紀雄、森光明子、吉川史隆
第44回 日本周産期・新生児医学会
KAKENHI (Grants-in-Aid for Scientific Research) 8
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ベトナムにおける妊産婦管理および婦人科rare tumorの学際的研究
2015.4
科学研究費補助金 基盤研究(A)
Authorship：Coinvestigator(s)
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Interdisciplinary study of obstetric management and gynecological rare tumor in Vietnam
Grant number：15H02660 2015.4 - 2020.3
FUMITAKA KIKKAWA
Authorship：Coinvestigator(s)
For the purpose of not only the development of obstetrics and gynecology in Vietnam, but also creation of evidence worldwide and building of medical research resources to Japan, we investigated obstetric management and gynecological rare tumor in Vietnam at several facilities in Vietnam. In the present study, several findings, which are related to improvement of mothers and children's prognosis,were gained. First, Pregnancy with dengue fever causes thrombocytopenia, which is at risk of postpartum hemorrhage. Second, cesarean section scar pregnancy with an increase in cesarean section rate in Vietnam, could be managed by medication for only selected patients. Third, evaluation of cardiac function by ultrasound examination for fetal growth restriction would be beneficial. Lastly, we found that there was a high secondary rate after molar pregnancy in Vietnam and preventive measures might improve it.
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分子レベルでの癒着胎盤の病態解明と新規バイオマーカー診断法の開発
2012.4 - 2016.3
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
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PATHOLOGICAL INVESTIGATION OF PLACENTA PREVIA ACCRETA: THE SITE OF UTERINE WALL AND THE WIDTH/DEPTH OF VILLOUS INVASION
Grant number：24791699 2012.4 - 2016.3
SUMIGAMA SEIJI
Authorship：Principal investigator
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
The objective of the current study is to examine molecular biological change of trophoblast invasion in placenta accreta by DNA microarray analysis. We isolated villous trophoblast from invasive site and control from non-invasive site in a case of placenta accreta and extracted complemantary DNA by RT-PCR. A DNA microarray analysis and Gene ontology analysis extracted overexpressed genes, MMP-19, ADAM-28, cathepsin S and cathepsin L. Immunohistochemistry of accreta cases revealed poor expression of MMP-19 and no difference between invasion and non-invasion site in ADAM-28 and cathepsin S, however a abundant expression of cathepsin L in especially in extra-villous trophoblast in invasion site. The serum cathepsin L level in placenta previa with accreta was significantly higher than those of normal pregnancy and placenta previa with no accreta. Thus, our data suggests a role for cathepsin L in the regulation of abnormal invasion of trophoblast in case of placenta accreta.
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前置癒着胎盤の病態解明と予知について
2007.4 - 2009.3
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
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To establish the prediction and to elucidate the pathophysiology of placenta previa accereta
Grant number：19591909 2007 - 2008
ITAKURA Atsuo
Authorship：Coinvestigator(s)
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転写因子AP-2による卵巣癌の抗癌剤耐性克服メカニズム及び遺伝子治療への展開
2005.4 - 2008.3
科学研究費補助金 若手研究(B)
Authorship：Principal investigator
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転写因子AP-2による卵巣癌の抗癌剤耐性克服メカニズム及び遺伝子治療への展開
Grant number：17791115 2005 - 2007
炭竈 誠二
Authorship：Principal investigator
Grant amount：\3500000 （ Direct Cost: \3500000 ）
・AP-2α遺伝子導入卵巣癌細胞における抗癌剤感受性の変化に関する検討
AP-2αを強制発現させた卵巣癌細胞株SKOV3においてタキソール・カルボプラチン・シスプラチン・ドキソルビシン・5FUへの感受性がそれぞれ1.26〜2.05倍に亢進していた。その機序として薬剤耐性受容体の発現変化の有無を検討した。ABCB1、ABCC1、ABCC2、ABCG2各受容体についてrealtime RT-PCRを行ったところ、AP-2α強制発現株において各受容体発現は0.92倍、1.09倍、1.12倍、0.89倍、1.21倍であり、有意な変化を示さなかった。また、SKOV3親株とmock株、AP-2α強制発現株においてp53のリン酸化につきWestern blottingにて検討したところ、AP-2α強制発現株においてリン酸化の亢進を認めた。
実験動物を用いたAP-2α遺伝子導入卵巣癌細胞株の病態と抗癌剤感受性
・AP-2α遺伝子導入細胞と親株をヌードマウスの大腿部皮下に接種し、生じる皮下腫瘍の大きさを経時的に計測した。接種3週後における腫瘍サイズは親株において平均80.5mm^3であったのに対しAP-2遺伝子導入細胞においては平均48.6mm^3であった。また、マウスの腹腔内にtaxo1を200μg投与した場合の腫瘍サイズは前者にて平均54.4mm^3であったのに対し後者では8.lmm^3と著明な増殖抑制効果を得た。これらより、AP-2α遺伝子導入によりin vivoにおいても腫瘍増殖抑制効果を、かつtaxolに対する感受性亢進効果を確認した。