Faculty Profiles - ENOMOTO, Atsushi

Papers - ENOMOTO, Atsushi

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The actin-binding protein girdin and its akt-mediated phosphorylation regulate neointima formation after vascular injury Reviewed

Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani-Sakakibara M, Yamamura Y, Kato K, Enomoto A, Takahashi M, Murohara T.

Vol. 108 ( 10 ) page： 1170-1179 2011

Girdin Is an Intrinsic Regulator of Neuroblast Chain Migration in the Rostral Migratory Stream of the Postnatal Brain Reviewed

Wang Y, Kaneko N, Asai N, Enomoto A, Isotani-Sakakibara M, Kato T, Asai M, Murakumo Y, Ota H, Hikita T, Namba T, Kuroda K, Kaibuchi K, Ming GL, Song H, Sawamoto K, Takahashi M.

Journal of Neuroscience Vol. 31 ( 22 ) page： 8109-8122 2011

Girding for migratory cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis Invited Reviewed

Weng L, Enomoto A, Ishida-Takagishi M, Asai N, Takahashi M.

Cancer Science Vol. 101 ( 4 ) page： 836-842 2010

Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus Reviewed

Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M.

Neuron Vol. 63 ( 6 ) page： 774-787 2009

An actin-binding protein Girdin regulates the motility of breast cancer cells Reviewed

Jiang, P., Enomoto, A., Jijiwa, M., Kato, T., Hasegawa, T., Ishida, M., Sato, T., Asai, N., Murakumo, Y., Takahashi, M.

Cancer Res Vol. 68 page： 1310-1318 2008

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. Reviewed

Kitamura, T.*, Asai, N.*, Enomoto, A.* (*joint first authorship), Maeda, K., Kato, T., Ishida, M., Jiang, P., Watanabe, T., Usukura, J., Kondo, T., Costantini, F., Murohara, T.

Nat Cell Biol Vol. 10 page： 329-337 2008

Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways Reviewed

Enomoto, A., P. Jiang, M. Takahashi

Ann N Y Acad Sci Vol. 1086 page： 169-184 2006

Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase Reviewed

Uchida, M., A. Enomoto, T. Fukuda, K. Kurokawa, K. Maeda, Y. Kodama, N. Asai, T. Hasegawa, Y. Shimono, M. Jijiwa, M. Ichihara, Y. Murakumo, M. Takahashi

J Cell Sci Vol. 119 page： 3067-3077 2006

Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells Reviewed

Asai, N., T. Fukuda, Z. Wu, A. Enomoto, V. Pachnis, M. Takahashi, F. Costantini

Development Vol. 133 page： 4507-4716 2006

Akt/PKB regulates actin organization and cell motility via Girdin/APE Reviewed

Enomoto, A., H. Murakami, N. Asai, N. Morone, T. Watanabe, K. Kawai, Y. Murakumo, J. Usukura, K. Kaibuchi, M. Takahashi

Developmental Cell Vol. 9 page： 389-402 2005

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

The serine/threonine kinase Akt (also called protein kinase B) is well known as an important regulator of cell survival and growth and has also been shown to be required for cell migration in different organisms. However, the mechanism by which Akt functions to promote cell migration is not understood. Here, we identify an Akt substrate, designated Girdin/APE (Akt-phosphorylation enhancer), which is an actin binding protein. Girdin expresses ubiquitously and plays a crucial role in the formation of stress fibers and lamellipodia. Akt phosphorylates serine at position 1416 in Girdin, and phosphorylated Girdin accumulates at the leading edge of migrating cells. Cells expressing mutant Girdin, in which serine 1416 was replaced with alanine, formed abnormal elongated shapes and exhibited limited migration and lamellipodia formation. These findings suggest that Girdin is essential for the integrity of the actin cytoskeleton and cell migration and provide a direct link between Akt and cell motility.

Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease Invited Reviewed

Enomoto, A., H. Endou

Clin Exp Nephrol Vol. 9 page： 195-205 2005

Molecular identification of a renal urate anion exchanger that regulates blood urate levels Reviewed

Enomoto, A., H. Kimura, A. Chairoungdua, Y. Shigeta, P. Jutabha, S. H. Cha, M. Hosoyamada, M. Takeda, T. Sekine, T. Igarashi, H. Matsuo, Y. Kikuchi, T. Oda, K. Ichida, T. Hosoya, K. Shimokata, T. Niwa, Y. Kanai, H. Endou

Nature Vol. 417 page： 447-452 2002

Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity Reviewed

Enomoto, A., M. Takeda, A. Tojo, T. Sekine, S. H. Cha, S. Khamdang, F. Takayama, I. Aoyama, S. Nakamura, H. Endou, T. Niwa

J Am Soc Nephrol Vol. 133 page： 1711-1720 2002

Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition Reviewed

Enomoto, A., M. F. Wempe, H. Tsuchida, H. J. Shin, S. H. Cha, N. Anzai, A. Goto, A. Sakamoto, T. Niwa, Y. Kanai, M. W. Anders, H. Endou

J Biol Chem Vol. 277 page： 36262-36271 2002

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Papers - ENOMOTO, Atsushi