Updated on 2024/03/21

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NATSUME, Jun
 
Organization
Graduate School of Medicine Department of developmental disability medicine Endowed Chair Designated professor
Title
Designated professor

Degree 1

  1. 医学博士 ( 名古屋大学 ) 

Research Interests 1

  1. Child Neurology, Epilepsy, Neuroimaging

Research Areas 1

  1. Others / Others  / Pediatrics

Current Research Project and SDGs 3

  1. PET、拡散テンソル画像によるWest症候群の病態解析

  2. グルコーストランスポーター1異常症についての研究

  3. 熱性けいれん重積症と後の側頭葉てんかん発症についての画像解析研究

Education 2

  1. Nagoya University   Graduate School, Division of Medicine

    1994.4 - 1998.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1984.4 - 1990.3

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    Country: Japan

Professional Memberships 7

  1. 日本小児神経学会   理事、評議員

  2. 日本てんかん学会   理事、評議員

  3. 日本小児科学会   代議員

  4. 日本臨床神経生理学会   代議員

  5. 日本重症心身障害学会   評議員

  6. American Epilepsy Society

  7. Asian and Oceanian Child Neurology Association

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Committee Memberships 14

  1. 日本小児神経学会   理事  

    2020.6   

  2. 日本てんかん学会   理事  

    2019.9   

  3. 日本小児神経学会長期計画委員会   委員長  

    2020.6   

  4. 日本てんかん学会英文ジャーナル委員会   委員長  

    2019.9   

  5. 日本小児神経学会熱性けいれん診療ガイドライン策定・改訂WG   委員長  

    2012.10   

  6. 日本重症心身障害学会   評議員  

    2014.8   

  7. 日本小児科学会   代議員  

    2010.4   

  8. 日本てんかん学会   評議員  

    2009.4   

  9. 日本小児神経学会   評議員  

    2007.6   

  10. 日本臨床神経生理学会   代議員  

    2017.5   

  11. 日本小児神経学会ガイドライン統括委員会   委員  

    2014.5 - 2022.6   

  12. 日本小児科学会英文誌編集委員会   委員  

    2016.9 - 2022.9   

  13. 日本てんかん学会分類・用語委員会   委員  

    2013.10 - 2021.9   

  14. 日本小児神経学会教育委員会   委員  

    2009.5 - 2015.5   

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Awards 2

  1. JUHN AND MARY WADA奨励賞

    2004.9   日本てんかん学会  

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    Country:Japan

  2. 研究褒賞

    2017.3   てんかん治療研究振興財団  

 

Papers 97

  1. Effect of levodopa on pathological gait in Dravet syndrome: A randomized crossover trial using three-dimensional gait analysis.

    Suzuki T, Natsume J, Ito Y, Ito T, Noritake K, Kinoshita F, Fukasawa T, Tsuji T, Itomi K, Kurahashi H, Kubota K, Okanishi T, Saitoh S, Sugiura H, Watanabe H, Takahashi Y, Kidokoro H

    Epilepsia     2024.3

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    Language:English  

    DOI: 10.1111/epi.17888

    PubMed

  2. Focus disconnection of the SEEG-identified epileptic network by radiofrequency thermal coagulation

    Ishizaki, T; Maesawa, S; Yamamoto, H; Hashida, M; Mutoh, M; Ito, Y; Tanei, T; Natsume, J; Saito, R

    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY   Vol. 111   page: 17 - 20   2023.10

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  3. A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents

    Shiohama, T; Maikusa, N; Kawaguchi, M; Natsume, J; Hirano, Y; Saito, K; Takanashi, JI; Levman, J; Takahashi, E; Matsumoto, K; Yokota, H; Hattori, S; Tsujimura, K; Sawada, D; Uchida, T; Takatani, T; Fujii, K; Naganawa, S; Sato, N; Hamada, H; Glaudemans, AWJM

    DIAGNOSTICS   Vol. 13 ( 17 )   2023.9

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  4. Two Cases of Juvenile Myelomonocytic Leukemia and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

    Yamamoto, H; Natsume, J; Kaneko, K; Takahashi, T; Wakamatsu, M; Ogawa, C; Kumai, S; Suzui, R; Sawamura, F; Shiraki, A; Nakata, T; Kidokoro, H; Muramatsu, H; Takahashi, Y

    PEDIATRIC NEUROLOGY   Vol. 144   page: 1 - 4   2023.7

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  5. Connectivity alteration in thalamic nuclei and default mode network-related area in memory processes in mesial temporal lobe epilepsy using magnetoencephalography

    Ishizaki, T; Maesawa, S; Nakatsubo, D; Yamamoto, H; Torii, J; Mutoh, M; Natsume, J; Hoshiyama, M; Saito, R

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 10632   2023.6

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  6. Intrauterine exposure to chorioamnionitis and neuroanatomical alterations at term-equivalent age in preterm infants

    Nosaka, R; Ushida, T; Kidokoro, H; Kawaguchi, M; Shiraki, A; Iitani, Y; Imai, K; Nakamura, N; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS     2023.5

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  7. Association between cerebrospinal fluid parameters and developmental and neurological status in glucose transporter 1 deficiency syndrome

    Nabatame, S; Tanigawa, J; Tominaga, K; Kagitani-Shimono, K; Yanagihara, K; Imai, K; Ando, T; Tsuyusaki, Y; Araya, N; Matsufuji, M; Natsume, J; Yuge, K; Bratkovic, D; Arai, H; Okinaga, T; Matsushige, T; Azuma, Y; Ishihara, N; Miyatake, S; Kato, M; Matsumoto, N; Okamoto, N; Takahashi, S; Hattori, S; Ozono, K

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 447   page: 120597   2023.4

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  8. Gait performance and dual-task costs in school-aged children with Down syndrome.

    Ito Y, Ito T, Ohno A, Kubota T, Tanemura K, Narahara S, Kataoka E, Hyodo R, Sugiyama Y, Hattori T, Kidokoro H, Sugiura H, Noritake K, Natsume J, Ochi N

    Brain & development   Vol. 45 ( 3 ) page: 171 - 178   2023.3

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    Language:English  

    DOI: 10.1016/j.braindev.2022.11.001

    PubMed

  9. Decreased Walking Efficiency in Elementary School Children with Developmental Coordination Disorder Trait

    Ito Tadashi, Sugiura Hideshi, Ito Yuji, Nakai Akio, Narahara Sho, Noritake Koji, Takahashi Daiki, Natsume Jun, Ochi Nobuhiko

    CLINICAL REHABILITATION     page: 2692155221150385   2023.1

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  10. Pathological gait in Rett syndrome: Quantitative evaluation using three-dimensional gait analysis

    Suzuki Takeshi, Ito Yuji, Ito Tadashi, Kidokoro Hiroyuki, Noritake Koji, Tsujimura Keita, Saitoh Shinji, Yamamoto Hiroyuki, Ochi Nobuhiko, Ishihara Naoko, Yasui Izumi, Sugiura Hideshi, Nakata Tomohiko, Natsume Jun

    EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY   Vol. 42   page: 15 - 21   2023.1

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  11. Medical records as screening tools for child death review in Japan

    Numaguchi, A; Ishii, A; Natsume, J; Saitoh, S; Aoki, Y; Yoshikawa, T; Isobe, I; Okumura, A; Seno, H; Takahashi, Y

    PEDIATRICS INTERNATIONAL   Vol. 65 ( 1 ) page: e15692   2023.1

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  12. Involvement of the Thalamus, Hippocampus, and Brainstem in Hypsarrhythmia of West Syndrome: Simultaneous Recordings of Electroencephalography and fMRI Study

    Maki Y., Natsume J., Ito Y., Okai Y., Bagarinao E., Yamamoto H., Ogaya S., Takeuchi T., Fukasawa T., Sawamura F., Mitsumatsu T., Maesawa S., Saito R., Takahashi Y., Kidokoro H.

    AMERICAN JOURNAL OF NEURORADIOLOGY   Vol. 43 ( 10 ) page: 1502 - 1507   2022.9

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  13. Forster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKII alpha activity in de novo mutations related to intellectual disability

    Fujii Hajime, Kidokoro Hiroyuki, Kondo Yayoi, Kawaguchi Masahiro, Horigane Shin-ichiro, Natsume Jun, Takemoto-Kimura Sayaka, Bito Haruhiko

    FRONTIERS IN MOLECULAR NEUROSCIENCE   Vol. 15   page: 970031   2022.9

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  14. Whole-exome analysis of 177 pediatric patients with undiagnosed diseases

    Narita Kotaro, Muramatsu Hideki, Narumi Satoshi, Nakamura Yuji, Okuno Yusuke, Suzuki Kyogo, Hamada Motoharu, Yamaguchi Naoya, Suzuki Atsushi, Nishio Yosuke, Shiraki Anna, Yamamori Ayako, Tsumura Yusuke, Sawamura Fumi, Kawaguchi Masahiro, Wakamatsu Manabu, Kataoka Shinsuke, Kato Kohji, Asada Hideyuki, Kubota Tetsuo, Muramatsu Yukako, Kidokoro Hiroyuki, Natsume Jun, Mizuno Seiji, Nakata Tomohiko, Inagaki Hidehito, Ishihara Naoko, Yonekawa Takahiro, Okumura Akihisa, Ogi Tomoo, Kojima Seiji, Kaname Tadashi, Hasegawa Tomonobu, Saitoh Shinji, Takahashi Yoshiyuki

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 14589   2022.8

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  15. Quantitative Three-Dimensional Gait Evaluation in Patients With Glucose Transporter 1 Deficiency Syndrome

    Suzuki Takeshi, Ito Yuji, Ito Tadashi, Kidokoro Hiroyuki, Noritake Koji, Hattori Ayako, Nabatame Shin, Natsume Jun

    PEDIATRIC NEUROLOGY   Vol. 132   page: 23 - 26   2022.7

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  16. Comprehensive Volumetric Analysis of <i>Mecp2</i>-Null Mouse Model for Rett Syndrome by T2-Weighted 3D Magnetic Resonance Imaging

    Akaba, Y; Shiohama, T; Komaki, Y; Seki, F; Ortug, A; Sawada, D; Uchida, W; Kamagata, K; Shimoji, K; Aoki, S; Takahashi, S; Suzuki, T; Natsume, J; Takahashi, E; Tsujimura, K

    FRONTIERS IN NEUROSCIENCE   Vol. 16   page: 885335   2022.5

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  17. Death review of children receiving medical care at home

    Natsume Jun, Numaguchi Atsushi, Ohno Atsuko, Mizuno Mihoko, Takahashi Yoshiyuki, Okumura Akihisa, Yoshikawa Tetsushi, Saitoh Shinji, Miura Kiyokuni, Noda Masaharu

    PEDIATRIC RESEARCH   Vol. 91 ( 5 ) page: 1286 - 1289   2022.4

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  18. Acute encephalopathy with biphasic seizures and late reduced diffusion: Predictive EEG findings

    Ohno Atsuko, Okumura Akihisa, Fukasawa Tatsuya, Nakata Tomohiko, Suzuki Motomasa, Tanaka Masaharu, Okai Yu, Ito Yuji, Yamamoto Hiroyuki, Tsuji Takeshi, Kidokoro Hiroyuki, Saitoh Shinji, Natsume Jun

    BRAIN & DEVELOPMENT   Vol. 44 ( 3 ) page: 221 - 228   2022.3

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  19. Dorsal myelopathy after nelarabine and intrathecal methotrexate therapy

    Sawamura Fumi, Natsume Jun, Nakata Tomohiko, Muramatsu Hideki, Takahashi Yoshiyuki

    PEDIATRICS INTERNATIONAL   Vol. 64 ( 1 ) page: e15334   2022.1

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  20. Involvement of brain structures in childhood epilepsy with centrotemporal spikes

    Ito Yuji, Maki Yuki, Okai Yu, Kidokoro Hiroyuki, Bagarinao Epifanio, Takeuchi Tomoya, Ohno Atsuko, Nakata Tomohiko, Ishihara Naoko, Okumura Akihisa, Yamamoto Hiroyuki, Maesawa Satoshi, Natsume Jun

    PEDIATRICS INTERNATIONAL   Vol. 64 ( 1 ) page: e15001   2022.1

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  21. Effectiveness of lacosamide in children and young adults previously treated with other sodium channel blockers

    Suzuki Takeshi, Natsume Jun, Kumai Sumire, Maki Yuki, Yamamoto Hiroyuki, Numoto Shingo, Narahara Sho, Kubota Tetsuo, Tsuji Takeshi, Kato Toru, Yamada Keitaro, Maruyama Koichi, Okumura Akihisa, Takahashi Yoshiyuki, Kidokoro Hiroyuki

    EPILEPSY & BEHAVIOR   Vol. 125   page: 108397   2021.12

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  22. Physical functions and gait performance in school-aged children born late preterm

    Ito Yuji, Ito Tadashi, Sugiura Hideshi, Kidokoro Hiroyuki, Sugiyama Yuichiro, Mizusawa Jun, Natsume Jun, Noritake Koji, Kato Yuichi, Ochi Nobuhiko

    EARLY HUMAN DEVELOPMENT   Vol. 163   page: 105478   2021.12

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  23. Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study

    Katsuki Satoru, Ushida Takafumi, Kidokoro Hiroyuki, Nakamura Noriyuki, Iitani Yukako, Fuma Kazuya, Imai Kenji, Nakano-Kobayashi Tomoko, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi

    EARLY HUMAN DEVELOPMENT   Vol. 163   page: 105479   2021.12

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  24. Trajectory of the incidence of brushes on preterm electroencephalogram and its association with neurodevelopment in extremely low birth weight infants

    Maeda Takashi, Kidokoro Hiroyuki, Tachibana Takashi, Shiraki Anna, Yamamoto Hiroyuki, Nakata Tomohiko, Fukasawa Tatsuya, Kubota Tetsuo, Sato Yoshiaki, Kato Toru, Natsume Jun, Okumura Akihisa, Hayakawa Masahiro

    BRAIN & DEVELOPMENT   Vol. 43 ( 10 ) page: 979 - 987   2021.11

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  25. Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study

    Ushida Takafumi, Kidokoro Hiroyuki, Nakamura Noriyuki, Katsuki Satoru, Imai Kenji, Nakano-Kobayashi Tomoko, Moriyama Yoshinori, Sato Yoshiaki, Hayakawa Masahiro, Natsume Jun, Kajiyama Hiroaki, Kotani Tomomi

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 25   page: 143 - 149   2021.8

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  26. Repetitive sleep starts: An important differential diagnosis of infantile spasms

    Maki Yuki, Kidokoro Hiroyuki, Okumura Akihisa, Yamamoto Hiroyuki, Nakata Tomohiko, Fukasawa Tatsuya, Kubota Tetsuo, Kawaguchi Masahiro, Suzuki Takeshi, Tanaka Masaharu, Okai Yu, Sakaguchi Yoko, Ohno Atsuko, Negoro Tamiko, Takahashi Yoshiyuki, Natsume Jun

    EPILEPSY & BEHAVIOR   Vol. 121 ( Pt A ) page: 108075   2021.8

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  27. Bilateral asymmetry in the gait deviation index in school-aged children with the trait of developmental coordination disorder

    Ito Tadashi, Ito Yuji, Nakai Akio, Sugiura Hideshi, Noritake Koji, Kidokoro Hiroyuki, Natsume Jun, Ochi Nobuhiko

    GAIT & POSTURE   Vol. 88   page: 174 - 179   2021.7

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  28. Risks of ACTH therapy for West syndrome following BCG vaccination

    Maki Yuki, Natsume Jun, Hori Ikumi, Takeuchi Tomoya, Negishi Yutaka, Kubota Tetsuo, Maruyama Koichi, Nakata Tomohiko, Yamamoto Hiroyuki, Tanaka Masaharu, Kawaguchi Masahiro, Suzuki Takeshi, Shiraki Anna, Sawamura Fumi, Kidokoro Hiroyuki

    EPILEPSY & BEHAVIOR   Vol. 118   page: 107924   2021.5

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  29. Hippocampal Atrophy in Pediatric Transplant Recipients with Human Herpesvirus 6B

    Miyake Misa, Kawamura Yoshiki, Ishihara Naoko, Suzuki Shigetaka, Miura Hiroki, Sakaguchi Yoko, Tanaka Masaharu, Takahashi Yoshiyuki, Kojima Seiji, Toyama Hiroshi, Natsume Jun, Yoshikawa Tetsushi

    MICROORGANISMS   Vol. 9 ( 4 )   2021.4

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  30. Successful treatment of a novel type I interferonopathy due to a de novo PSMB9 gene mutation with a Janus kinase inhibitor.

    Kataoka S, Kawashima N, Okuno Y, Muramatsu H, Miwata S, Narita K, Hamada M, Murakami N, Taniguchi R, Ichikawa D, Kitazawa H, Suzuki K, Nishikawa E, Narita A, Nishio N, Yamamoto H, Fukasawa Y, Kato T, Yamamoto H, Natsume J, Kojima S, Nishino I, Taketani T, Ohnishi H, Takahashi Y

    The Journal of allergy and clinical immunology     2021.3

  31. Age estimates from brain magnetic resonance images of children younger than two years of age using deep learning.

    Kawaguchi M, Kidokoro H, Ito R, Shiraki A, Suzuki T, Maki Y, Tanaka M, Sakaguchi Y, Yamamoto H, Takahashi Y, Naganawa S, Natsume J

    Magnetic resonance imaging   Vol. 79   page: 38 - 44   2021.3

  32. The eldest case of MICPCH with CASK mutation exhibiting gross motor regression

    Nishio Yosuke, Kidokoro Hiroyuki, Takeo Toshiki, Narita Hajime, Sawamura Fumi, Narita Kotaro, Kawano Yoshihiko, Nakata Tomohiko, Muramatsu Hideki, Hara Shinya, Kaname Tadashi, Natsume Jun

    BRAIN & DEVELOPMENT   Vol. 43 ( 3 ) page: 459 - 463   2021.3

  33. Whole genome sequencing of 45 Japanese patients with intellectual disability

    Abe-Hatano Chihiro, Iida Aritoshi, Kosugi Shunichi, Momozawa Yukihide, Terao Chikashi, Ishikawa Keiko, Okubo Mariko, Hachiya Yasuo, Nishida Hiroya, Nakamura Kazuyuki, Miyata Rie, Murakami Chie, Takahashi Kan, Hoshino Kyoko, Sakamoto Haruko, Ohta Sayaka, Kubota Masaya, Takeshita Eri, Ishiyama Akihiko, Nakagawa Eiji, Sasaki Masayuki, Kato Mitsuhiro, Matsumoto Naomichi, Kamatani Yoichiro, Kubo Michiaki, Takahashi Yoshiyuki, Natsume Jun, Inoue Ken, Goto Yu-Ichi

    AMERICAN JOURNAL OF MEDICAL GENETICS PART A     2021.2

  34. Initial treatment of seizures in children in an emergency department in rural Japan

    Shiraki Anna, Yasui Masahiro, Kidokoro Hiroyuki, Kido Shinji, Ando Hideo, Takahashi Yoshiyuki, Natsume Jun

    BRAIN & DEVELOPMENT   Vol. 43 ( 2 ) page: 288 - 293   2021.2

  35. Shuffling babies and autism spectrum disorder

    Okai Yu, Nakata Tomohiko, Miura Kiyokuni, Ohno Atsuko, Wakako Rie, Takahashi Osamu, Maki Yuki, Tanaka Masaharu, Sakaguchi Yoko, Ito Yuji, Yamamoto Hiroyuki, Kidokoro Hiroyuki, Takahashi Yoshiyuki, Natsume Jun

    BRAIN & DEVELOPMENT   Vol. 43 ( 2 ) page: 181 - 185   2021.2

  36. Lenticular nuclei to thalamic ratio on PET is useful for diagnosis of GLUT1 deficiency syndrome

    Natsume Jun, Ishihara Naoko, Azuma Yoshiteru, Nakata Tomohiko, Takeuchi Tomoya, Tanaka Masaharu, Sakaguchi Yoko, Okai Yu, Ito Yuji, Yamamoto Hiroyuki, Ohno Atsuko, Kidokoro Hiroyuki, Hattori Ayako, Nabatame Shin, Kato Katsuhiko

    BRAIN & DEVELOPMENT   Vol. 43 ( 1 ) page: 69 - 77   2021.1

  37. Gait characteristics of children with Williams syndrome with impaired visuospatial recognition: a three-dimensional gait analysis study

    Ito Yuji, Ito Tadashi, Kurahashi Naoko, Ochi Nobuhiko, Noritake Koji, Sugiura Hideshi, Mizuno Seiji, Kidokoro Hiroyuki, Natsume Jun, Nakamura Miho

    EXPERIMENTAL BRAIN RESEARCH   Vol. 238 ( 12 ) page: 2887 - 2895   2020.12

  38. MRI findings in children with congenital cytomegalovirus infection retrospectively diagnosed with dried umbilical cord

    Kidokoro Hiroyuki, Shiraki Anna, Torii Yuka, Tanaka Masaharu, Yamamoto Hiroyuki, Kurahashi Hirokazu, Maruyama Koichi, Okumura Akihisa, Natsume Jun, Ito Yoshinori

    NEURORADIOLOGY     2020.11

  39. Change of White Matter Integrity in Children With Hematopoietic Stem Cell Transplantation

    Sakaguchi Yoko, Natsume Jun, Kidokoro Hiroyuki, Tanaka Masaharu, Okai Yu, Ito Yuji, Yamamoto Hiroyuki, Ohno Atsuko, Nakata Tomohiko, Nakane Toshiki, Kawai Hisashi, Taoka Toshiaki, Muramatsu Hideki, Naganawa Shinji, Takahashi Yoshiyuki

    PEDIATRIC NEUROLOGY   Vol. 111   page: 78 - 84   2020.10

  40. Evaluation of interobserver variability in application of the new neonatal seizure classification proposed by the ILAE Task Force

    Kubota Tetsuo, Kidokoro Hiroyuki, Narahara Sho, Fukasawa Tatsuya, Nakata Tomohiko, Natsume Jun, Okumura Akihisa

    EPILEPSY & BEHAVIOR   Vol. 111   page: 107292   2020.10

  41. High-amplitude fast activity in EEG: An early diagnostic marker in children with beta-propeller protein-associated neurodegeneration (BPAN)

    Kidokoro Hiroyuki, Yamamoto Hiroyuki, Kubota Tetsuo, Motobayashi Mitsuo, Miyamoto Yusaku, Nakata Tomohiko, Takano Kyoko, Shiba Naoko, Okai Yu, Tanaka Masaharu, Sakaguchi Yoko, Maki Yuki, Kawaguchi Masahiro, Suzuki Takeshi, Muramatsu Kazuhiro, Natsume Jun

    CLINICAL NEUROPHYSIOLOGY   Vol. 131 ( 9 ) page: 2100 - 2104   2020.9

  42. Splenial Lesions in Benign Convulsions With Gastroenteritis Associated With Rotavirus Infection

    Ogawa Chikako, Kidokoro Hiroyuki, Ishihara Naoko, Tsuji Takeshi, Kurahashi Hirokazu, Hattori Ayako, Suzuki Motomasa, Ogaya Shunsuke, Ito Yuji, Fukasawa Tatsuya, Kubota Tetsuo, Okumura Akihisa, Saitoh Shinji, Natsume Jun

    PEDIATRIC NEUROLOGY   Vol. 109   page: 79 - 84   2020.8

  43. Transient cortical diffusion restriction in children immediately after prolonged febrile seizures

    Suzuki Takeshi, Kidokoro Hiroyuki, Kubota Tetsuo, Fukasawa Tatsuya, Suzui Ryosuke, Tsuji Takeshi, Kato Toru, Yamamoto Hiroyuki, Ohno Atsuko, Nakata Tomohiko, Saitoh Shinji, Okumura Akihisa, Natsume Jun

    EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY   Vol. 27   page: 30 - 36   2020.7

  44. Clinical findings in patients with febrile seizure after 5 years of age: A retrospective study

    Ogino Motoko, Kashiwagi Mitsuru, Tanabe Takuya, Oba Chizu, Nomura Shohei, Shimakawa Shuichi, Kidokoro Hiroyuki, Natsume Jun, Okumura Akihisa, Tamai Hiroshi, Ashida Akira

    BRAIN & DEVELOPMENT   Vol. 42 ( 6 ) page: 449 - 456   2020.6

  45. y Distributed source analysis of magnetoencephalography using a volume head model combined with statistical methods improves focus diagnosis in epilepsy surgery

    Ishizaki Tomotaka, Maesawa Satoshi, Nakatsubo Daisuke, Yamamoto Hiroyuki, Takai Sou, Shibata Masashi, Kato Sachiko, Natsume Jun, Hoshiyama Minoru, Wakabayashi Toshihiko

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 5263   2020.3

  46. Subsecond EEG-fMRI analysis for presurgical evaluation in focal epilepsy.

    Ito Y, Maesawa S, Bagarinao E, Okai Y, Nakatsubo D, Yamamoto H, Kidokoro H, Usui N, Natsume J, Hoshiyama M, Wakabayashi T, Sobue G, Ozaki N

    Journal of neurosurgery     page: 1 - 10   2020.3

  47. Respiratory illness and acute flaccid myelitis in the Tokai district in 2018

    Okumura Akihisa, Numoto Shingo, Iwayama Hideyuki, Kurahashi Hirokazu, Natsume Jun, Saitoh Shinji, Yoshikawa Tetsushi, Fukao Toshiyuki, Hirayama Masahiro, Takahashi Yoshiyuki

    PEDIATRICS INTERNATIONAL   Vol. 62 ( 3 ) page: 337 - 340   2020.3

  48. Pseudo-sawtooth pattern on amplitude-integrated electroencephalography in neonatal hypoxic-ischemic encephalopathy

    Tanaka Masaharu, Kidokoro Hiroyuki, Kubota Tetsuo, Fukasawa Tatsuya, Okai Yu, Sakaguchi Yoko, Ito Yuji, Yamamoto Hiroyuki, Ohno Atsuko, Nakata Tomohiko, Negoro Tamiko, Okumura Akihisa, Kato Toru, Watanabe Kazuyoshi, Takahashi Yoshiyuki, Natsume Jun

    PEDIATRIC RESEARCH   Vol. 87 ( 3 ) page: 529 - 535   2020.2

  49. Novel biallelic FA2H mutations in a Japanese boy with fatty acid hydroxylase-associated neurodegeneration

    Kawaguchi Masahiro, Sassa Takayuki, Kidokoro Hiroyuki, Nakata Tomohiko, Kato Kohji, Muramatsu Hideki, Okuno Yusuke, Yamamoto Hiroyuki, Kaname Tadashi, Kihara Akio, Natsume Jun

    BRAIN & DEVELOPMENT   Vol. 42 ( 2 ) page: 217 - 221   2020.2

  50. Attitudes of school teachers toward epilepsy in Nagoya, Japan

    Okumura Akihisa, Saitoh Shinji, Natsume Jun, Yamamoto Hiroyuki, Kurahashi Hirokazu, Numoto Shingo

    EPILEPSY & BEHAVIOR   Vol. 103 ( Pt A ) page: 106359   2020.2

  51. The effect of the guidelines for management of febrile seizures 2015 on clinical practices: Nationwide survey in Japan

    Tanaka Masaharu, Natsume Jun, Hamano Shin-ichiro, Iyoda Kuniaki, Kanemura Hideaki, Kubota Masaya, Mimaki Masakazu, Niijima Shin-ichi, Tanabe Takuya, Yoshinaga Harumi, Kojimahara Noriko, Komaki Hirofumi, Sugai Kenji, Fukuda Tokiko, Maegaki Yoshihiro, Sugie Hideo

    BRAIN & DEVELOPMENT   Vol. 42 ( 1 ) page: 28 - 34   2020.1

  52. Delayed recognition of childhood arterial ischemic stroke

    Hori Ikumi, Tsuji Takeshi, Miyake Misa, Ueda Kazuto, Kataoka Erina, Suzuki Michio, Kobayashi Satoru, Kurahashi Hirokazu, Takahashi Yoshiyuki, Okumura Akihisa, Yoshikawa Tetsushi, Saitoh Shinji, Natsume Jun

    PEDIATRICS INTERNATIONAL   Vol. 61 ( 9 ) page: 895 - 903   2019.9

  53. Risk factors for absence of catch-up growth in small for gestational age very low-birthweight infants

    Arai Sakiko, Sato Yoshiaki, Muramatsu Hideki, Yamamoto Hidenori, Aoki Fumiko, Okai Yu, Kataoka Shinsuke, Hanada Yu, Hamada Motoharu, Morimoto Yoshihito, Kojima Seiji, Natsume Jun, Takahashi Yoshiyuki, Sugiyama Yuichiro, Hoshino Shin, Kawada Junichi, Kidokoro Hiroyuki, Hayakawa Masahiro, Hattori Tetsuo, Kato Yuichi, Yasuda Ayako, Oshiro Makoto, Takemoto Koji, Nishimura Naoko, Hayashi Seiji, Hyodo Reina, Ito Masatoki, Narahara Shou, Ieda Kuniko, Yamamoto Hikaru

    PEDIATRICS INTERNATIONAL   Vol. 61 ( 9 ) page: 889 - 894   2019.9

  54. Comparison of Clinical Characteristics of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Young Children

    Taniguchi Akinobu, Kawada Jun-ichi, Go Kiyotaka, Fujishiro Naozumi, Hosokawa Yosuke, Maki Yuki, Sugiyama Yuichiro, Suzuki Michio, Tsuji Takeshi, Hoshino Shin, Muramatsu Hideki, Kidokoro Hiroyuki, Kinoshita Fumie, Hirakawa Akihiro, Takahashi Yoshiyuki, Sato Yoshiaki, Natsume Jun, Yamakawa Kiyoshi, Okumura Akihisa, Kato Toru, Nagai Noriko, Moriyama Miyako, Miyajima Yuji, Yamamori Kazuki, Shibata Motohiro, Hasegawa Masayuki, Shinohara Osamu, Nishimura Naoko, Aoshima Tsutomu, Morishita Masashi, Nomura Yoji, Kuraishi Kenji

    JAPANESE JOURNAL OF INFECTIOUS DISEASES   Vol. 72 ( 4 ) page: 237 - 242   2019.7

  55. Hippocampal diffusion abnormality after febrile status epilepticus is related to subsequent epilepsy

    Yokoi Setsuri, Kidokoro Hiroyuki, Yamamoto Hiroyuki, Ohno Atsuko, Nakata Tomohiko, Kubota Tetsuo, Tsuji Takeshi, Morishita Masashi, Kawabe Takashi, Naiki Misako, Maruyama Koichi, Itomi Kazuya, Kato Toru, Ito Komei, Natsume Jun

    EPILEPSIA   Vol. 60 ( 7 ) page: 1306 - 1316   2019.7

  56. Novel non-invasive modalities for presurgical evaluation in focal epilepsy

    Ito Yuji, Yamamoto Hiroyuki, Okanishi Tohru, Maesawa Satoshi, Natsume Jun

    PEDIATRICS INTERNATIONAL   Vol. 61 ( 3 ) page: 319 - 321   2019.3

  57. Anatomo-electro-clinical correlations of hypermotor seizures with amygdala enlargement: Hippocampal seizure origin identified using stereoelectroencephalography.

    Ishizaki T, Maesawa S, Nakatsubo D, Yamamoto H, Shibata M, Kato S, Yoshida M, Natsume J, Hoshiyama M, Wakabayashi T

    Epilepsy & behavior case reports   Vol. 11   page: 10 - 13   2019

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    DOI: 10.1016/j.ebcr.2018.09.011

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  58. Correction: Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial.

    Ogawa C, Sato Y, Suzuki C, Mano A, Tashiro A, Niwa T, Hamazaki S, Tanahashi Y, Suzumura M, Hayano S, Hayakawa M, Tsuji T, Hoshino S, Sugiyama Y, Kidokoro H, Kawada JI, Muramatsu H, Hirakawa A, Ando M, Natsume J, Kojima S

    PloS one   Vol. 14 ( 6 ) page: e0218205   2019

  59. Ureteral dilatation detected in magnetic resonance imaging predicts vesicoureteral reflux in children with urinary tract infection

    Murakami Norihiro, Kawada Jun-ichi, Watanabe Azumi, Arakawa Toshinao, Kano Takamasa, Suzuki Takako, Tanaka Ryo, Kojima Daiei, Kawano Yoshihiko, Hoshino Shin, Muramatsu Hideki, Takahashi Yoshiyuki, Sato Yoshiaki, Koyama Masashi, Natsume Jun

    PLOS ONE   Vol. 13 ( 12 ) page: e0209595   2018.12

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    DOI: 10.1371/journal.pone.0209595

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  60. Longitudinal Findings of MRI and PET in West Syndrome with Subtle Focal Cortical Dysplasia

    Sakaguchi Y., Kidokoro H., Ogawa C., Okai Y., Ito Y., Yamamoto H., Ohno A., Nakata T., Tsuji T., Nakane T., Kawai H., Kato K., Naganawa S., Natsume J.

    AMERICAN JOURNAL OF NEURORADIOLOGY   Vol. 39 ( 10 ) page: 1932-1937   2018.10

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    DOI: 10.3174/ajnr.A5772

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  61. Magnetic resonance spectroscopy in preterm infants: association with neurodevelopmental outcomes

    Hyodo Reina, Sato Yoshiaki, Ito Miharu, Sugiyama Yuichiro, Ogawa Chikako, Kawai Hisashi, Nakane Toshiki, Saito Akiko, Hirakawa Akihiro, Kidokoro Hiroyuki, Natsume Jun, Hayakawa Masahiro

    ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION   Vol. 103 ( 3 ) page: F238-F244   2018.5

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    DOI: 10.1136/archdischild-2016-311403

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  62. Survey of rotavirus-associated severe complications in Aichi Prefecture.

    Hattori F, Kawamura Y, Kawada JI, Kojima S, Natsume J, Ito K, Saito S, Kitagawa Y, Okumura A, Yoshikawa T, Aichi Pediatric Clinical Study Group.

    Pediatrics international : official journal of the Japan Pediatric Society   Vol. 60 ( 3 ) page: 259-263   2018.3

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    DOI: 10.1111/ped.13506

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  63. The efficacy of adrenocorticotropic hormone in a girl with anti-N-methyl-D-aspartate receptor encephalitis

    Hatanaka Mari, Shimakawa Shuichi, Okumura Akihisa, Natsume Jun, Fukui Miho, Nomura Shohei, Kashiwagi Mitsuru, Tamai Hiroshi

    BRAIN & DEVELOPMENT   Vol. 40 ( 3 ) page: 247-250   2018.3

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    DOI: 10.1016/j.braindev.2017.10.003

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  64. Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial

    Ogawa Chikako, Sato Yoshiaki, Suzuki Chiyo, Mano Azusa, Tashiro Atsushi, Niwa Takafumi, Hamazaki Sayako, Tanahashi Yoshihiro, Suzumura Midori, Hayano Satoshi, Hayakawa Masahiro, Tsuji Takeshi, Hoshino Shin, Sugiyama Yuichiro, Kidokoro Hiroyuki, Kawada Jun-ichi, Muramatsu Hideki, Hirakawa Akihiro, Ando Masahiko, Natsume Jun, Kojima Seiji

    PLOS ONE   Vol. 13 ( 2 ) page: e0192688   2018.2

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    DOI: 10.1371/journal.pone.0192688

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  65. Cytotoxic edema at onset in West syndrome of unknown etiology: A longitudinal diffusion tensor imaging study

    Ogawa Chikako, Kidokoro Hiroyuki, Fukasawa Tatsuya, Yamamoto Hiroyuki, Ishihara Naoko, Ito Yuji, Sakaguchi Yoko, Okai Yu, Ohno Atsuko, Nakata Tomohiko, Azuma Yoshiteru, Hattori Ayako, Kubota Tetsuo, Tsuji Takeshi, Hirakawa Akihiro, Kawai Hisashi, Natsume Jun

    EPILEPSIA   Vol. 59 ( 2 ) page: 440-448   2018.2

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    DOI: 10.1111/epi.13988

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  66. Detecting sub-second changes in brain activation patterns during interictal epileptic spike using simultaneous EEG-fMRI

    Bagarinao Epifanio, Maesawa Satoshi, Ito Yuji, Usui Naotaka, Natsume Jun, Watanabe Hirohisa, Hoshiyama Minoru, Wakabayashi Toshihiko, Sobue Gen, Naganawa Shinji, Isoda Haruo

    CLINICAL NEUROPHYSIOLOGY   Vol. 129 ( 2 ) page: 377-389   2018.2

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    DOI: 10.1016/j.clinph.2017.11.018

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  67. Predominant area of brain lesions in neonates with herpes simplex encephalitis

    Kidokoro H., de Vries L. S., Ogawa C., Ito Y., Ohno A., Groenendaal F., Saitoh S., Okumura A., Ito Y., Natsume J.

    JOURNAL OF PERINATOLOGY   Vol. 37 ( 11 ) page: 1210-1214   2017.11

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    DOI: 10.1038/jp.2017.114

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  68. Characteristics of epilepsy in patients with Kabuki syndrome with KMT2D mutations

    Kurahashi Naoko, Miyake Noriko, Mizuno Seiji, Koshimizu Eriko, Kurahashi Hirokazu, Yamada Keitaro, Natsume Jun, Aoki Yusuke, Nakamura Miho, Taniai Hiroko, Maki Yuki, Abe-Hatano Chihiro, Matsumoto Naomichi, Maruyama Koichi

    BRAIN & DEVELOPMENT   Vol. 39 ( 8 ) page: 672-677   2017.9

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    DOI: 10.1016/j.braindev.2017.03.025

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  69. Phenotype-genotype correlations of PIGO deficiency with variable phenotypes from infantile lethality to mild learning difficulties

    Tanigawa Junpei, Mimatsu Haruka, Mizuno Seiji, Okamoto Nobuhiko, Fukushi Daisuke, Tominaga Koji, Kidokoro Hiroyuki, Muramatsu Yukako, Nishi Eriko, Nakamura Shota, Motooka Daisuke, Nomura Noriko, Hayasaka Kiyoshi, Niihori Tetsuya, Aoki Yoko, Nabatame Shin, Hayakawa Masahiro, Natsume Jun, Ozono Keiichi, Kinoshita Taroh, Wakamatsu Nobuaki, Murakami Yoshiko

    HUMAN MUTATION   Vol. 38 ( 7 ) page: 805-815   2017.7

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    DOI: 10.1002/humu.23219

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  70. Paroxysmal nonepileptic events in children with epilepsy

    Ito Yuji, Kidokoro Hiroyuki, Negoro Tamiko, Tanaka Masaharu, Okai Yu, Sakaguchi Yoko, Ogawa Chikako, Takeuchi Tomoya, Ohno Atsuko, Yamamoto Hiroyuki, Nakata Tomohiko, Maesawa Satoshi, Watanabe Kazuyoshi, Takahashi Yoshiyuki, Natsume Jun

    EPILEPSY RESEARCH   Vol. 132   page: 59-63   2017.5

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    DOI: 10.1016/j.eplepsyres.2017.02.009

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  71. Acute disseminated encephalomyelitis in China, Singapore, and Japan: a comparison with the USA

    Koelman Diederik, Benkeser David, Xu Yan, Neo Shermyn, Tan Kevin, Katsuno Masahisa, Sobue Gen, Natsume Jun, Chahin Salim, Mar Soe, Venkatesan Arun, Chitnis Tanuja, Hoganson George, Yeshokumar Anusha, Barreras Paula, Majmudar Bittu, Carone Marco, Mateen Farrah

    NEUROLOGY   Vol. 88   2017.4

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  72. Acute disseminated encephalomyelitis in China, Singapore and Japan: a comparison with the USA

    Koelman D. L. H., Benkeser D. C., Xu Y., Neo S. X., Tan K., Katsuno M., Sobue G., Natsume J., Chahin S., Mar S. S., Venkatesan A., Chitnis T., Hoganson G. M., Yeshokumar A. K., Barreras P., Majmudar B., Carone M., Mateen F. J.

    EUROPEAN JOURNAL OF NEUROLOGY   Vol. 24 ( 2 ) page: 391-396   2017.2

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    DOI: 10.1111/ene.13220

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  73. New guidelines for management of febrile seizures in Japan

    Natsume Jun, Hamano Shin-ichiro, Iyoda Kuniaki, Kanemura Hideaki, Kubota Masaya, Mimaki Masakazu, Niijima Shinichi, Tanabe Takuya, Yoshinaga Harumi, Kojimahara Noriko, Komaki Hirohumi, Sugai Kenji, Fukuda Tokiko, Maegaki Yoshihiro, Sugie Hideo

    BRAIN & DEVELOPMENT   Vol. 39 ( 1 ) page: 2-9   2017.1

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    DOI: 10.1016/j.braindev.2016.06.003

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  74. White matter abnormality correlates with developmental and seizure outcomes in West syndrome of unknown etiology. Reviewed

    Natsume J, Ogawa C, Fukasawa T, Yamamoto H, Ishihara N, Sakaguchi Y, Ito Y, Takeuchi T, Azuma Y, Ando N, Kubota T, Tsuji T, Kawai H, Naganawa S, Kidokoro H.

    AJNR Am J Neuroradiol.     page: *   2016

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  75. TUBA1A mutation can cause a hydranencephaly-like severe form of cortical dysgenesis.

    Yokoi S, Ishihara N, Miya F, Tsutsumi M, Yanagihara I, Yamamoto H, Kato M, Okamoto N, Tsunoda T, Yamasaki M, Kanemura Y, Kosaki K, Saitoh S, Kurahash H, Natsume J.

    Sci. Rep.     page: *   2016

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    DOI: *

  76. Clinical and neuroimaging findings in children with posterior reversible encephalopathy syndrome.

    Yamamoto H, Natsume J, Kidokoro H, Ishihara N, Suzuki M, Tsuji T, Kubota T, Yamada A, Ozeki M, Kato Z, Kawamura Y, Yoshikawa T, Okumura A, Ando N, Saitoh S, Takahashi Y, Watanabe K, Kojima S.

    Eur J Paediatr Neurol.   Vol. 19 ( 6 ) page: 672-678   2015.7

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  77. Two siblings with cortical dysplasia: Clinico-electroencephalographic features.

    Fukasawa T, Kubota T, Negoro T, Maruyama S, Honda R, Saito Y, Itoh M, Kakita A, Sugai K, Otsuki T, Kato M, Natsume J, Watanabe K.

    Pediatr Int.   Vol. 57 ( 3 ) page: 472-475   2015.5

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  78. Positron emission tomography in infancy predicts long-term outcome during adolescence in cryptogenic West syndrome. Reviewed

    Natsume J, Maeda N, Itomi K, Kidokoro H, Ishihara N, Takada H, Okumura A, Kubota T, Miura K, Aso K, Morikawa T, Kato K, Negoro T, Watanabe K.

    AJNR Am J Neuroradiol.     page: in press   2015

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    DOI: in press

  79. A severity score for acute necrotizing encephalopathy.

    Yamamoto H, Okumura A, Natsume J, Kojima S, Mizuguchi M.

    Brain Dev.   Vol. 37 ( 3 ) page: 322-7   2015

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  80. Congenital myasthenic syndrome in Japan: Ethnically unique mutations in muscle nicotinic acetylcholine receptor subunits.

    Azuma Y, Nakata T, Tanaka M, Shen XM, Ito M, Iwata S, Okuno T, Nomura Y, Ando N, Ishigaki K, Ohkawara B, Masuda A, Natsume J, Kojima S, Sokabe M, Ohno K.

    Neuromuscul Disord.   Vol. 25 ( 1 ) page: 60-69   2015

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  81. Seizure characteristics of epilepsy in childhood after acute encephalopathy with biphasic seizures and late reduced diffusion.

    Ito Y, Natsume J, Kidokoro H, Ishihara N, Azuma Y, Tsuji T, Okumura A, Kubota T, Ando N, Saitoh S, Miura K, Negoro T, Watanabe K, Kojima S.

    Epilepsia   Vol. 56 ( 8 ) page: 1286-1293   2015

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  82. Nationwide survey of glucose transporter-1 deficiency syndrome (GLUT-1DS) in Japan.

    Ito Y, Takahashi S, Kagitani-Shimono K, Natsume J, Yanagihara K, Fujii T, Oguni H.

    Brain Dev.   Vol. 37 ( 8 ) page: 780-789   2014.12

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  83. Thalamic lesions in acute encephalopathy with biphasic seizures and late reduced diffusion.

    Kurahashi N, Tsuji T, Kato T, Ogaya S, Umemura A, Yamada K, Kurahashi H, Maruyama K, Takeuchi T, Kubota T, Saitoh S, Natsume J, Okumura A.

    Pediatr Neurol.   Vol. 51 ( 5 ) page: 701-705   2014

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  84. A new electroencephalogram classification with reduced recording time in asphyxiated term infants.

    Kato T, Tsuji T, Hayakawa F, Kubota T, Kidokoro H, Natsume J, Watanabe K, Okumura A.

    Brain Dev.   Vol. 36 ( 5 ) page: 372-379   2014

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  85. Characteristics of epilepsy occurring in the first four months.

    Fukasawa T, Suzuki M, Kato T, Hayakawa F, Miura K, Kidokoro H, Kubota T, Okumura A, Maruyama K, Hishikawa Y, Itomi K, Negoro T, Watanabe K, Natsume J.

    Brain Dev.   Vol. 36 ( 9 ) page: 752-757   2014

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  86. A novel WTX mutation in a female patient with osteopathia striata with cranial sclerosis and hepatoblastoma.

    Fujita A, Ochi N, Fujimaki H, Muramatsu H, Takahashi Y, Natsume J, Kojima S, Nakashima M, Tsurusaki Y, Saitsu H, Matsumoto N, Miyake N.

    Am J Med Genet A.   Vol. 164A ( 4 ) page: 998-1002   2014

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  87. Paradoxical downward seizure pattern on amplitude-integrated electroencephalogram.

    Ito M, Kidokoro H, Sugiyama Y, Sato Y, Natsume J, Watanabe K, Hayakawa M.

    J Perinatol.   Vol. 34 ( 8 ) page: 642-644   2014

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  88. *Alpha-[11C]methyl-L-tryptophan uptake in patients with periventricular nodular heterotopia and epilepsy. Reviewed

    Natsume J, Bernasconi N, Aghakhani Y, KumakuraY, Nishikawa M, Fedi M, Soualmi L, Dubeau F, Andermann F, Bernasconi A, Diksic M.

    Epilepsia   Vol. 49 ( 5 ) page: 826-831   2008.5

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  89. *Hippocampal volumes and diffusion weighted image findings in children with prolonged febrile seizures. Invited Reviewed

    Natsume J, Bernasconi N, Miyauchi M, Naiki M, Yokotsuka T, Sofue A, Bernasconi A.

    Acta Neurol Scand   Vol. 115 ( 4 ) page: 25-28   2007

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  90. Transient splenial lesions in children with "benign convulsions with gastroenteritis". Reviewed

    Natsume J, Naiki M, Yokotsuka T, Sofue A, Ikuta T, Kondo Y, Negoro T.

    Brain Dev   Vol. 29 ( 8 ) page: 519-521   2007

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  91. Electroencephalographic (EEG) findings in posterior reversible encephalopathy associated with immunosuppressants. Reviewed

    Natsume J, Sofue A, Yamada A, Kato K.

    J Child Neurol   Vol. 21 ( 7 ) page: 620-623   2006

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  92. *alpha-[11C] methyl-L-tryptophan and glucose metabolism in patients with temporal lobe epilepsy. Reviewed

    Natsume J, Kumakura Y, Bernasconi N, Soucy J-P, Nakai A, Rosa P, Fedi M. Dubeau F, Andermann F, Lisbona R, Bernasconi A, and Diksic M.

    Neurology   Vol. 60 ( 5 ) page: 756-761   2003

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  93. *MRI volumetry of the thalamus in temporal, extratemporal and idiopathic generalized epilepsy. Reviewed

    Natsume J, Bernasconi N, Andermann F, Bernasconi A.

    Neurology   Vol. 60 ( 8 ) page: 1296-1300   2003

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  94. Widespread Glucose Hypometabolism in Patients with Hippocampal Atrophy: Evaluation with 18F-fluorodeoxyglucose Positron Emission Tomography. Reviewed

    Natsume J, Watanabe K, Tadokoro M, Negoro T, Aso K, Nakashima S, Maeda N, Ohta T, Ikeda M and Yamada T.

    J Epilepsy   Vol. 10   page: 155-160   1997

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  95. *Cortical hypometabolism and delayed myelination in West syndrome. Reviewed

    Natsume J, Watanabe K, Maeda N, Kasai K, Negoro T, Aso K, Nakashima S, Tadokoro M.

    Epilepsia   Vol. 37 ( 12 ) page: 1180-1184   1996

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  96. Cryptogenic localization-related epilepsy of neonatal onset. Reviewed

    Natsume J, Watanabe K, Negoro T, Aso K, Kasai K, Maeda N, Ohki T, Horiuchi K.

    Seizure   Vol. 5   page: 317-319   1996

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  97. Clinical, neurophysiologic, and neuropathological features of an infant with brain damage of total asphyxia type (Myers). Reviewed

    Natsume J, Watanabe K, Kuno K, Hayakawa F, Hashizume Y.

    Pediatr Neurol   Vol. 13   page: 61-64   1995

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Books 1

  1. Bioimaging in neurodegeneration

    ( Role: Joint author)

    Humana Press  2005 

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    Language:English

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. Research for development of connectome-based functional neurosurgery and non-invasive simulation system

    Grant number:22H03184  2022.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s) 

  2. 先進的MRI解析によるDuchenne型筋ジストロフィーの脳構造・機能異常の解明

    Grant number:20K08204  2020.4 - 2023.3

    夏目 淳

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    D/BMD患者30名、健常小児20名のMRI撮像、2022年度に画像解析を行い、以下を明らかにし、D/BMD患者における認知・精神発達特性の基盤を明らかにし、リハビリテーション、呼吸補助装置、意思伝達デバイスを用いる際の参考になる情報を得る。研究成果を学会発表し、論文として報告する。
    1) 健常者と比較したD/BMD患者の脳の微細構造、脳機能の異常を明らかにする。2) D/BMDのうち、知的障害、発達障害を持つ患者の脳構造、脳機能の特徴を明らかにする。3) D/BMDのうち、遺伝子検査でDp140の有無による脳の微細構造、脳機能の異常を明らかにする。

  3. 脳波-近赤外分光法同時記録を用いたサブプレート・ニューロンの脳血流動態の解明

    Grant number:20K08228  2020.4 - 2023.3

    城所 博之

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    サブプレート・ニューロンは、発達期の脳皮質の形成や脳内ネットワークの構築に重要な役割を果たす。ヒト早産児に高率に認める発達障害の病態にも、サブプレート・ニューロンの障害が大きく関与すると考えるが、ヒトでは未解明である。動物実験を通じて、ヒト早産児脳波に見られるブラッシュがサブプレート・ニューロンの活動を反映することが示された。本研究では、1) 脳波に機能的近赤外分光法(fNIRS)を同時記録することでサブプレート・ニューロンの脳局所血流動態を明らかにする。さらに、2) サブプレート・ニューロンの活動が、生後18か月の神経発達や脳皮質構造や脳内ネットワークに及ぼす効果を明らかにする。

  4. Elucidation of altered neural network in the preterm brain based on spindle bursts in EEG, and its clinical regulation

    Grant number:17K10075  2017.4 - 2020.3

    Kidokoro Hiroyuki

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    During human brain development, spindles burst is a crucial spontaneous activity in EEG. The aim of this study was to elucidate the effect of the electrical activity on functional and structural brain development. We found that in extremely premature infants brushes corresponding to spindle bursts in animals occurred most frequently at 36 postmenstrual weeks. Additionally, the brush occurrence at 36 postmenstrual weeks was associated with white matter abnormality on brain MRI and in turn associated with neurodevelopmental outcomes at 18 months of corrected age. We also showed that functional and structural MRI reveals associations with neurodevelopment at 18 months of corrected age. These data indicated that brushes in EEG contribute to the altered brain development in preterm infants.

  5. simultaneous EEG-fMRI analysis in West syndrome

    Grant number:16K09987  2016.4 - 2019.3

    Natsume Jun

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    We examined 7 patients with West syndrome (6 patients with cryptogenic West syndrome and 1 with tuberous sclerosis complex) by EEG-fMRI at the onset of West syndrome before ACTH therapy. The temporal information of periodic hypsarrhythmia was used to perform event-related analysis for detecting hypsarrhythmia-related blood oxygenation level-dependent (BOLD) changes on fMRI. As a result, positive BOLD changes were seen in brainstem and multiple cerebral cortices in 6 of 7 patients. After ACTH therapy epileptic spasms disappeared in all patients. However spasms relapsed in 2 patients and focal seizures were seen in 2. At 12 months of age, 3 patients had focal epileptiform discharges. EEG-fMRI at 12 months of age in these 3 patients revealed bilateral frontal positive BOLD in 2 patients and left hippocampal positive BOLD in 1. Positive BIOLD signal in the brainstem disappeared at 12 months of age in all 3 patients.

  6. MRⅠ、PETによる小児熱性けいれん重積における側頭葉てんかん発症機序の解明  

    2008

    科学研究費補助金  基盤研究(C),課題番号:20591222

    夏目 淳

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    Authorship:Principal investigator 

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Social Contribution 1

  1. 脳とこころの研究センター市民公開講座

    2015.2

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