Organization
Nagoya University Hospital Breast and Endocrine Surgery Associate professor of hospital
Title
Associate professor of hospital
KIKUMORI, Toyone
Degree 1
-
M.D., Ph.D （ 1999.3 Nagoya University ）
Research Interests 1
-
breast and endocrine surgery
Research Areas 1
-
Others / Others / Breast and Endocrine Surgery
Current Research Project and SDGs 2
-
生化学的方法を用いた副甲状腺の鑑別方法の開発
-
褐色細胞腫・傍神経節腫に対する摘出術術後の血糖変動の検討
Research History 5
-
Nagoya University Associate professor of hospital
2022.8
-
Nagoya University Breast and Endocrine Surgery Lecturer
2013.2 - 2022.7
-
Nagoya University Breast and Endocrine Surgery Assistant Professor
2010.7 - 2013.1
-
Nagoya University Breast and Endocrine Surgery Assistant professor of hospital
2007.11 - 2010.6
-
Nagoya University Assistant
2005.4 - 2007.10
Education 2
-
Nagoya University Graduate School, Division of Medicine
1995.4 - 1999.3
Country： Japan
-
Nagoya University Faculty of Medicine
1983.4 - 1989.3
Country： Japan
Professional Memberships 6
-
日本癌治療学会
-
Japan Society for Endoscopic Surgery
-
Japan Association of Endocrine Surgeons
-
Japan Breast Cancer Society
-
Japan Surgical Society
-
Japan Thyroid Association
Awards 2
-
学会賞
2019.6 日本内分泌外科学会
-
best paper award
1997.6 Japan Association of Endocrine Surgery
Papers 49
-
Elevated TSH Level, TgAb, and Prior Use of Ramucirumab or TKIs as Risk Factors for Thyroid Dysfunction in PD-L1 Blockade
Kobayashi Tomoko, Iwama Shintaro, Yamagami Ayana, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Zhou Xin, Ando Masahiko, Onoue Takeshi, Miyata Takashi, Sugiyama Mariko, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Ito Takanori, Kikumori Toyone, Inoue Megumi, Ando Yuichi, Masuda Norikazu, Kawashima Hiroki, Hashimoto Naozumi, Arima Hiroshi
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM Vol. 107 ( 10 ) page： E4115 - E4123 2022.9
-
Prediction of the Presence of Fluid Accumulation in the Subcutaneous Tissue in BCRL Using Texture Analysis of Ultrasound Images
Niwa Shiori, Mawaki Ayana, Hisano Fumiya, Nakanishi Keisuke, Watanabe Sachiyo, Fukuyama Atsushi, Kikumori Toyone, Shimamoto Kazuhiro, Fujimoto Etsuko, Oshima Chika
LYMPHATIC RESEARCH AND BIOLOGY Vol. 20 ( 1 ) page： 11 - 16 2022.2
-
Platelet isoform of phosphofructokinase accelerates malignant features in breast cancer
Inaishi Takahiro, Shibata Masahiro, Ichikawa Takahiro, Kanda Mitsuro, Hayashi Masamichi, Soeda Ikumi, Takeuchi Dai, Takano Yuko, Tsunoda Nobuyuki, Kodera Yasuhiro, Kikumori Toyone
ONCOLOGY REPORTS Vol. 47 ( 1 ) 2022.1
-
S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model
Miyajima Noriyuki, Eissa Ibrahim Ragab, Abdelmoneim Mohamed, Naoe Yoshinori, Ichinose Toru, Matsumura Shigeru, Bustos-Villalobos Itzel, Mukoyama Nobuaki, Morimoto Daishi, Shibata Masahiro, Takeuchi Dai, Tsunoda Nobuyuki, Kikumori Toyone, Tanaka Maki, Kodera Yasuhiro, Kasuya Hideki
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 83 ( 4 ) page： 683 - 696 2021.11
-
Authors' Reply: Development of a Rapid Intraoperative Point-of-Care Method Using Tissue Suspension to Differentiate Parathyroid Tissue: A Possible Substitute for Frozen Sections
Kikumori Toyone, Shibata Masahiro, Takeuchi Dai
WORLD JOURNAL OF SURGERY Vol. 45 ( 11 ) page： 3476 - 3477 2021.11
-
Identifying the tumor-progressive gene expression profile in high-risk papillary thyroid cancer
Shibata Masahiro, Inaishi Takahiro, Ichikawa Takahiro, Shimizu Dai, Soeda Ikumi, Takano Yuko, Takeuchi Dai, Tsunoda Nobuyuki, Kikumori Toyone
SURGERY TODAY Vol. 51 ( 10 ) page： 1703 - 1712 2021.10
-
Synaptotagmin 13 Is Highly Expressed in Estrogen Receptor-Positive Breast Cancer
Ichikawa Takahiro, Shibata Masahiro, Inaishi Takahiro, Soeda Ikumi, Kanda Mitsuro, Hayashi Masamichi, Takano Yuko, Takeuchi Dai, Tsunoda Nobuyuki, Kodera Yasuhiro, Kikumori Toyone
CURRENT ONCOLOGY Vol. 28 ( 5 ) page： 4080 - 4092 2021.10
-
The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia
Kozawa Kei, Sekai Miho, Ohba Kenji, Ito Shoko, Sako Hiroaki, Maruyama Takeshi, Kakeno Mai, Shirai Takanobu, Kuromiya Keisuke, Kamasaki Tomoko, Kohashi Koki, Tanaka Shinya, Ishikawa Susumu, Sato Nanami, Asano Shota, Suzuki Hironori, Tanimura Nobuyuki, Mukai Yohei, Gotoh Noriko, Tanino Mishie, Tanaka Shinya, Natsuga Ken, Soga Tomoyoshi, Nakamura Tomonori, Yabuta Yukihiro, Saitou Mitinori, Ito Takahiro, Matsuura Kenkyo, Tsunoda Makoto, Kikumori Toyone, Iida Tadashi, Mizutani Yasuyuki, Miyai Yuki, Kaibuchi Kozo, Enomoto Atsushi, Fujita Yasuyuki
CURRENT BIOLOGY Vol. 31 ( 14 ) page： 3086 - + 2021.7
-
Development of a Rapid Intraoperative Point-of-Care Method Using Tissue Suspension to Differentiate Parathyroid Tissue: A Possible Substitute for Frozen Sections
Kikumori Toyone, Shibata Masahiro, Takeuchi Dai
WORLD JOURNAL OF SURGERY Vol. 45 ( 7 ) page： 2142 - 2145 2021.7
-
MZB1 expression indicates poor prognosis in estrogen receptor-positive breast cancer
Watanabe Manabu, Shibata Masahiro, Inaishi Takahiro, Ichikawa Takahiro, Soeda Ikumi, Miyajima Noriyuki, Takano Yuko, Takeuchi Dai, Tsunoda Nobuyuki, Kanda Mitsuro, Kikumori Toyone, Kodera Yasuhiro, Nagino Masato
ONCOLOGY LETTERS Vol. 20 ( 5 ) page： 198 2020.11
-
Utility of urinary type I collagen cross-linked N-telopeptide as a prognostic indicator in breast cancer patients with bone metastases
Shizuku Masato, Shibata Masahiro, Okumura Mai, Takeuchi Dai, Kikumori Toyone, Mizuno Yutaka
BREAST CANCER Vol. 27 ( 6 ) page： 1065 - 1071 2020.11
-
Measurement of the AST to LD Ratio in Parathyroid Tissue Suspension Can Precisely Differentiate a Hyperfunctioning Parathyroid
Kikumori Toyone, Ichikawa Takahiro, Inaishi Takahiro, Miyajima Noriyuki, Shibata Masahiro, Takeuchi Dai
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM Vol. 105 ( 8 ) page： E2764 - E2769 2020.8
-
A phase I/II trial of intraoperative breast radiotherapy in an Asian population: 10-year results with critical evaluation
Kawamura Mariko, Itoh Yoshiyuki, Kamomae Takeshi, Sawaki Masataka, Kikumori Toyone, Tsunoda Nobuyuki, Ito Junji, Shimoyama Yoshie, Satake Hiroko, Naganawa Shinji
JOURNAL OF RADIATION RESEARCH Vol. 61 ( 4 ) page： 602 - 607 2020.7
-
Clinical value of serum bone resorption markers for predicting clinical outcomes after use of bone modifying agents in metastatic bone tumors: A prospective cohort study
Urakawa Hiroshi, Ando Yuichi, Hase Tetsunari, Kikumori Toyone, Arai Eisuke, Maeda Osamu, Mitsuma Ayako, Sugishita Mihoko, Shimokata Tomoya, Ikuta Kunihiro, Ishiguro Naoki, Nishida Yoshihiro
INTERNATIONAL JOURNAL OF CANCER Vol. 146 ( 12 ) page： 3504 - 3515 2020.6
-
Frequent FOXA1-Activating Mutations in Extramammary Paget's Disease
Takeichi Takuya, Okuno Yusuke, Matsumoto Takaaki, Tsunoda Nobuyuki, Suzuki Kyogo, Tanahashi Kana, Kono Michihiro, Kikumori Toyone, Muro Yoshinao, Akiyama Masashi
CANCERS Vol. 12 ( 4 ) 2020.4
-
Robust, quick, and convenient intraoperative method to differentiate parathyroid tissue
Kikumori Toyone, Inaishi Takahiro, Miyajima Noriyuki, Shibata Masahiro, Takeuchi Dai
SURGERY Vol. 167 ( 2 ) page： 385 - 389 2020.2
-
Correlation Between the Metabolic Conversion of a Capecitabine Metabolite, 5 '-Deoxy-5-fluorocytidine, and Creatinine Clearance
Inaishi Takahiro, Fujita Ken-Ichi, Matsumoto Natsumi, Shimokata Tomoya, Maeda Osamu, Kikumori Toyone, Hattori Norifumi, Nakayama Goro, Ando Yuichi
IN VIVO Vol. 34 ( 6 ) page： 3539 - 3544 2020
-
A longitudinal tracking and quantitative assessment of paclitaxel-induced peripheral neurotoxicity
Matsuoka A., Mitsuma A., Maeda O., Tsunoda N., Kikumori T., Ando Y.
ANNALS OF ONCOLOGY Vol. 30 2019.10
-
Multicenter Phase II Study of Intraoperative Radiotherapy of Early Breast Cancer: Ipsilateral Tumor Recurrence
Sawaki Masataka, Miyamoto Takeshi, Fujisawa Tomomi, Itoh Yoshiyuki, Ebara Takeshi, Tachibana Hiroyuki, Kodaira Takeshi, Kikumori Toyone, Yanagita Yasuhiro, Iwata Hiroji
ANNALS OF SURGICAL ONCOLOGY Vol. 26 ( 8 ) page： 2428 - 2434 2019.8
-
RASEF expression correlates with hormone receptor status in breast cancer
Shibata Masahiro, Kanda Mitsuro, Shimizu Dai, Tanaka Haruyoshi, Umeda Shinichi, Miwa Takashi, Hayashi Masamichi, Inaishi Takahiro, Miyajima Noriyuki, Adachi Yayoi, Takano Yuko, Nakanishi Kenichi, Takeuchi Dai, Noda Sumiyo, Kodera Yasuhiro, Kikumori Toyone
ONCOLOGY LETTERS Vol. 16 ( 6 ) page： 7223 - 7230 2018.12
-
Impact of Patient Age and Histological Type on Radioactive Iodine Avidity of Recurrent Lesions of Differentiated Thyroid Carcinoma
Nakanishi Kenichi, Kikumori Toyone, Miyajima Noriyuki, Takano Yuko, Noda Sumiyo, Takeuchi Dai, Iwano Shingo, Kodera Yasuhiro
CLINICAL NUCLEAR MEDICINE Vol. 43 ( 7 ) page： 482 - 485 2018.7
-
Feasibility of dose-dense epirubicin and cyclophosphamide with subcutaneous pegfilgrastim 3.6 mg support: a single-center prospective study in Japan Reviewed
Morita Sachi, Kikumori Toyone, Tsunoda Nobuyuki, Inaishi Takahiro, Adachi Yayoi, Ota Akiko, Shibata Masahiro, Matsuoka Ayumu, Nakanishi Kenichi, Takeuchi Dai, Mizutani Takefumi, Shimokata Tomoya, Hayashi Hironori, Maeda Osamu, Ando Yuichi
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY Vol. 23 ( 1 ) page： 195 - 200 2018.2
-
Obesity does not affect peri- and postoperative outcomes of transabdominal laparoscopic adrenalectomy
Inaishi Takahiro, Kikumori Toyone, Takeuchi Dai, Ishihara Hiromasa, Miyajima Noriyuki, Shibata Masahiro, Takano Yuko, Nakanishi Kenichi, Noda Sumiyo, Kodera Yasuhiro
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 80 ( 1 ) page： 21 - 28 2018.2
-
Acute phase dynamics of circulating tumor cells after paclitaxel and doxorubicin chemotherapy in breast cancer mouse models. Reviewed
Adachi Y, Yoshimura M, Nishida K, Usuki H, Shibata K, Hattori M, Kondo N, Yatabe Y, Iwata H, Kikumori T, Kodera Y, Nakanishi H
Breast cancer research and treatment Vol. 167 ( 2 ) page： 439 - 450 2018.1
-
Synchronous bilateral pheochromocytomas and paraganglioma with novel germline mutation in MAX: a case report
Shibata Masahiro, Inaishi Takahiro, Miyajima Noriyuki, Adachi Yayoi, Takano Yuko, Nakanishi Kenichi, Takeuchi Dai, Noda Sumiyo, Aita Yuichi, Takekoshi Kazuhiro, Kodera Yasuhiro, Kikumori Toyone
SURGICAL CASE REPORTS Vol. 3 2017.12
-
Synchronous bilateral pheochromocytomas and paraganglioma with novel germline mutation in MAX: a case report. Reviewed
Shibata M, Inaishi T1, Miyajima N, Adachi Y, Takano Y, Nakanishi K, Takeuchi D, Noda S, Aita Y, Takekoshi K, Kodera Y, Kikumori T.
Surg Case Rep Vol. 3 ( 1 ) page： 131 2017.12
-
The efficacy of eribulin mesylate with trastuzumab for locally advanced or metastatic HER2-positive breast cancer treated with prior pertuzumab and/or T-DM1: Results from a phase II, single arm, multicenter study (N-SOG 10 study)
Fujii M., Tsunoda N., Hattori M., Murata T., Akahane K., Kamei K., Goto Y., Amemiya T., Nishimae K., Kubota T., Ito Y., Kurumiya Y., Yoshihara M., Nakanishi K., Kikumori T., Ando M., Nagino M.
ANNALS OF ONCOLOGY Vol. 28 2017.11
-
Overexpression of Derlin 3 is associated with malignant phenotype of breast cancer cells. Reviewed
Shibata M, Kanda M, Tanaka H, Umeda S, Miwa T, Shimizu D, Hayashi M, Inaishi T, Miyajima N, Adachi Y, Takano Y, Nakanishi K, Takeuchi D, Noda S, Kodera Y, Kikumori T
Oncology reports Vol. 38 ( 3 ) page： 1760 - 1766 2017.9
-
Expression of regulatory factor X1 can predict the prognosis of breast cancer. Reviewed
Shibata M, Kanda M, Shimizu D, Tanaka H, Umeda S, Hayashi M, Inaishi T, Miyajima N, Adachi Y, Takano Y, Nakanishi K, Takeuchi D, Noda S, Kodera Y, Kikumori T
Oncology letters Vol. 13 ( 6 ) page： 4334 - 4340 2017.6
-
Multi-center rater-blinded study of early intervention with the Hand Incubator for breast cancer-related lymphedema (the BEAT-EDEMA trial): Proposal of a research protocol. Reviewed
Ishii H, Iwatsuki K, Tatebe M, Hirata H, Kikumori T, Tsunoda N, Hyodo I, Ogawa T, Unno N
Nagoya journal of medical science Vol. 79 ( 2 ) page： 221 - 227 2017.5
-
Assessment of left ventricular diastolic function during trastuzumab treatment in patients with HER2-positive breast cancer. Reviewed
Honda K, Takeshita K, Murotani K, Mitsuma A, Hayashi H, Tsunoda N, Kikumori T, Murohara T, Ando Y
Breast cancer (Tokyo, Japan) Vol. 24 ( 2 ) page： 312 - 318 2017.3
-
Survey on QOL and cosmesis after intraoperative radiotherapy (IORT) in a multicenter phase II study of patients with early breast cancer
Sawaki M., Miyamoto T., Fujisawa T., Yanagita Y., Kodaira T., Kikumori T., Iwata H.
BREAST Vol. 32 page： S75 - S75 2017.3
-
Synchronous bilateral pheochromocytomas and paraganglioma with novel germline mutation in MAX: a case report. Reviewed
Shibata M, Inaishi T, Miyajima N, Adachi Y, Takano Y, Nakanishi K, Takeuchi D, Noda S, Aita Y, Takekoshi K, Kodera Y, Kikumori T.
Surg Case Rep. Vol. 28 ( 3 ) page： 131 2017
-
Comparison of clinical outcomes between luminal invasive ductal carcinoma and luminal invasive lobular carcinoma. Reviewed
Adachi Y, Ishiguro J, Kotani H, Hisada T, Ichikawa M, Gondo N, Yoshimura A, Kondo N, Hattori M, Sawaki M, Fujita T, Kikumori T, Yatabe Y, Kodera Y, Iwata H.
BMC Cancer Vol. 16 ( 248 ) page： doi: 10.1186/s12885-016-2275-4. 2016.5
-
Bone Scan Index predicts skeletal-related events in patients with metastatic breast cancer. Reviewed
Idota A, Sawaki M, Yoshimura A, Hattori M, Inaba Y, Oze I, Kikumori T, Kodera Y, Iwata H
SpringerPlus Vol. 5 ( 1 ) page： 1095 2016
-
Bevacizumab Exacerbates Paclitaxel-Induced Neuropathy: A Retrospective Cohort Study. Reviewed
Matsuoka A, Maeda O, Mizutani T, Nakano Y, Tsunoda N, Kikumori T, Goto H, Ando Y
PloS one Vol. 11 ( 12 ) page： e0168707 2016
-
Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides. Reviewed
Takano Y, Kasai K, Takagishi Y, Kikumori T, Imai T, Murata Y, Hayashi Y.
PLoS One Vol. 10 ( 7 ) 2015.6
-
Combination therapy of oncolytic herpes simplex virus HF10 and bevacizumab against experimental model of human breast carcinoma xenograft. Reviewed
Tan G, Kasuya H, Sahin TT, Yamamura K, Wu Z, Koide Y, Hotta Y, Shikano T, Yamada S, Kanzaki A, Fujii T, Sugimoto H, Nomoto S, Nishikawa Y, Tanaka M, Tsurumaru N, Kuwahara T, Fukuda S, Ichinose T, Kikumori T, Takeda S, Nakao A, Kodera Y.
Int J Cancer Vol. １３６ ( ７ ) page： 1718-30 2015.4
-
Prognostic significance of changes in serum thyroglobulin antibody levels of pre- and post-total thyroidectomy in thyroglobulin antibody-positive papillary thyroid carcinoma patients. Reviewed
Tsushima Y, Miyauchi A, Ito Y, Kudo T, Masuoka H, Yabuta T, Fukushima M, Kihara M, Higashiyama T, Takamura Y, Kobayashi K, Miya A, Kikumori T, Imai T, Kiuchi T.
Endocr J. Vol. 60 ( 7 ) page： 871-6 2013.4
-
Clinical features of insulinoma in patients with multiple endocrine neoplasia type 1: analysis of the database of the MEN Consortium of Japan. Reviewed
Clinical features of insulinoma in patients with multiple endocrine neoplasia type 1: analysis of the database of the MEN Consortium of Japan.
Endocr J Vol. 59 ( 10 ) page： 859-66 2012.6
-
Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer. Reviewed
Sahin TT, Kasuya H, Nomura N, Shikano T, Yamamura K, Gewen T, Kanzaki A, Fujii T, Sugae T, Imai T, Nomoto S, Takeda S, Sugimoto H, Kikumori T, Kodera Y, Nishiyama Y, Nakao A.
Cancer Gene Ther. Vol. 19 ( 4 ) page： 229-37 2011.12
-
Insignificance of prophylactic upper mediastinal lymph node dissection by sternotomy for papillary thyroid carcinoma. Reviewed
Kikumori T, Imai T.
Endocr J. 2011
-
*Anti-cancer effect of hyperthermia on breast cancer by magnetite nanoparticle-loaded anti-HER2 immunoliposomes. Reviewed
Kikumori T, Kobayashi T, Sawaki M, Imai T.
Breast Cancer Res Treat Vol. 113 ( 3 ) page： 435-441 2009.3
-
*Intracaval endovascular ultrasonography for large adrenal and retroperitoneal tumors Reviewed
T. Kikumori, T. Imai, T. Kaneko, H. Sugimoto, A. Shibata, Y. Hibi, & A. Nakao
Surgery Vol. 134 page： 989-993 2003
-
Naturally occurring heterologous trans-splicing of adenovirus RNA with host cellular transcripts during infection Reviewed
T. Kikumori, G. J. Cote, & R. F. Gagel
FEBS Lett Vol. 522 page： 41-46 2002
-
*Promiscuity of pre-mRNA spliceosome-mediated trans splicing: a problem for gene therapy? Reviewed
T. Kikumori, G. J. Cote, & R. F. Gagel
Hum Gene Ther Vol. 12 page： 1429-1441 2001
-
Thyrotropin modifies activation of nuclear factor kappaB by tumour necrosis factor alpha in rat thyroid cell line Reviewed
T. Kikumori, F. Kambe, T. Nagaya, H. Funahashi, & H. Seo
Biochem J Vol. 354 page： 573-579 2001
-
*Parathyroid autotransplantation with total thyroidectomy for thyroid carcinoma: long-term follow-up of grafted parathyroid function Reviewed
T. Kikumori, T. Imai, Y. Tanaka, M. Oiwa, T. Mase, & H. Funahashi
Surgery Vol. 125 page： 504-508 1999
-
Activation of transcriptionally active nuclear factor-kappaB by tumor necrosis factor-alpha and its inhibition by antioxidants in rat thyroid FRTL-5 cells Reviewed
T. Kikumori, F. Kambe, T. Nagaya, T. Imai, H. Funahashi, & H. Seo
Endocrinology Vol. 139 page： 1715-1722 1998
Books 1
-
*Surgical Endocrinology
T. Kikumori, D. Evans, J. E. Lee, G. J. Cote, R. F. Gagel（ Role： Joint author）
Lippincott Williams & Wilkins, USA 2001
Research Project for Joint Research, Competitive Funding, etc. 1
-
熱ショックタンパクをターゲットとした悪性腫瘍に対する温熱治療の研究
2006
KAKENHI (Grants-in-Aid for Scientific Research) 5
-
グルカゴン遺伝子ノックアウトマウスを用いた膵内分泌腫瘍に対する治療・予防法の開発
2015.4 - 2017.3
科学研究費補助金 基盤研究(C)
Authorship：Principal investigator
-
上皮間葉移行（ＥＭＴ）阻害による高度悪性甲状腺癌に対する治療法の開発 課題番号24591897
2012.4 - 2015.3
科学研究費補助金 基盤研究(C)
菊森 豊根
Authorship：Principal investigator
外科的切除以外に有効な治療法が現在のところほとんど存在しない甲状腺低分化癌およびほとんどすべての治療に抵抗性であり、きわめて悪性度の高い甲状腺未分化癌に対する治療法として、転移、浸潤に深く関与しているEMTに注目して新規治療法の可能性を探る。EMTはtumor growth factor β (TGFβ)により誘導されることが知られている。TGFβの受容体の安定化に熱ショックタンパクであるHsp90が必要とされている。Hsp90特異的阻害剤によるTGFβ作用抑制によりEMTが阻害されることにより高度悪性甲状腺癌の転移、浸潤能が抑制されるかどうかを検討する。また温熱とHsp90阻害剤のTGFβ作用抑制に対する相加/相乗効果があるかどうかを検討する。
-
Grant number：18K08590 2018.4 - 2021.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Kikumori Toyone
Authorship：Principal investigator
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
In a mouse model of spontaneous pancreatic neuroendocrine tumors that frequently cause liver metastasis and peritoneal dissemination, we investigated whether tumor immunosuppression contributes to disease progression and can suppress disease progression by activating tumor immunity. An attempt was made to examine the activation of immune cells in the primary and metastatic lesions of pancreatic neuroendocrine tumors in this model mouse by immunohistochemical staining, but the staining conditions were not determined and could not be examined. Regarding the activation of tumor immunity by drugs, which was planned to continue, the evaluation method was not determined and no results could be obtained.
-
Care for patients with both diabetes and secondary lymphedema
Grant number：16H05563 2016.4 - 2020.3
FUJIMOTO Etsuko
Authorship：Coinvestigator(s)
We attempted to establish a care program for breast cancer-related lymphedema in diabetic patients. We examined from various viewpoints based on the complete decongestive therapy (CDT).
MR images of the forearm revealed that fluid accumulates in ulnar side more than radial side. Therefore, it is recommended that the drainage should focus on this part. After 120 minutes of meal, it was found that blood pressure stabilize. Hence CDT should be carried out at 120 minutes after a meal. Because the evaluation using a tape measure or subjective symptoms was not sufficient, in order to understand the situation of edema, magnetic resonance imaging or ultrasonic diagnostic imaging is necessary. In self-care, it is important to visually grasp the effects of care in order to encourage patients. For this purpose, we considered to use a 3D scanner. -
Development of treatment and prevention for pancreatic neuroendocrine tumor using glucagon gene knock-out mouse
Grant number：15K10049 2015.4 - 2018.3
Kikumori Toyone
Authorship：Principal investigator
Grant amount：\4940000 （ Direct Cost: \3800000 、 Indirect Cost：\1140000 ）
We explored treatment / prevention methods by clarifying pathologically and molecular biologically the biological properties of tumor developed in glucagon gene knockout mouse in which pancreatic tumors arose spontaneously. We reported that the pancreatic tumor developed in this mouse closely resembles histological and biological attitudes to human pancreatic neuroendocrine tumor (pNET). Expression of cellular growth factors and angiogenic factors (AKT, mTOR, VEGF, etc.) in pancreatic islet cells at each stage of the process of malignant transformation were examined by immunostaining of excised tissue specimens. Everolimus, an mTOR inhibitor which has clinical indication for pNET, was continued to be administered to these mice shortly after birth, and it was confirmed that pancreatic tumor development was suppressed.