Papers - NAGATA, Kohzo
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L-arginine ameliorates hypertension and cardiac mitochondrial abnormalities but not cardiac injury in male metabolic syndrome rats Reviewed
Tagami K, Okuzawa T, Yoshida K, Mishima R, Obara N, Kunimatsu A, Koide M, Teranishi T, Itakura K, Ikeda K, Murohara T, Nagata K
Physiological Reports Vol. 13 ( 4 ) page： e70183 2025.2
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Sacubitril/valsartan improves diastolic left ventricular stiffness with increased titin phosphorylation via cGMP-PKG activation in diabetic mice Reviewed Open Access
Furukawa N, Matsui H, Sunaga H, Nagata K, Hirayama M, Obinata H, Yokoyama T, Ohno K, Kurabayashi M, Koitabashi N
Scientific Reports Vol. 14 ( 1 ) page： 25081 2024.10
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Comparison of the effects of renal denervation at early or advanced stages of hypertension on cardiac, renal, and adipose tissue pathology in Dahl salt-sensitive rats (A comment published by the journal) Reviewed
Nagata K, Tagami K, Okuzawa T, Hayakawa M, Nomura A, Nishimura T, Ikeda K, Kitada K, Kobuchi S, Fujisawa Y, Nishiyama A, Murohara T
Hypertension Research Vol. 47 ( 10 ) page： 2731 - 2744 2024.10
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Staining, magnification, and algorithmic conditions for highly accurate cell detection and cell classification by deep learning Reviewed
Ikeda K, Sakabe N, Ito C, Shimoyama Y, Toda K, Fukuda K, Yoshizaki Y, Sato S, Nagata K
American Journal of Clinical Pathology Vol. 161 ( 4 ) page： 399 - 410 2024.4
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Relationship between a deep learning model and liquid-based cytological processing techniques Reviewed
Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Oboshi W, Komene T, Yamaguchi Y, Sato S, Nagata K
Cytopathology Vol. 34 ( 4 ) page： 308 - 317 2023.7
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Relationship between Liquid-Based Cytology Preservative Solutions and Artificial Intelligence: Liquid-Based Cytology Specimen Cell Detection Using YOLOv5 Deep Convolutional Neural Network Reviewed
Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Sato S, Nagata K
Acta Cytologica Vol. 66 ( 6 ) page： 542 - 550 2022.9
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Pharmacological inhibition of the lipid phosphatase PTEN ameliorates heart damage and adipose tissue inflammation in stressed rats with metabolic syndrome Reviewed
Ashikawa S, Komatsu Y, Kawai Y, Aoyama K, Nakano S, Cui X, Hayakawa M, Sakabe N, Furukawa N, Ikeda K, Murohara T, Nagata K
Physiological Reports Vol. 10 ( 1 ) page： e15165 2022.1
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Characterizing the Effect of Processing Technique and Solution Type on Cytomorphology Using Liquid-Based Cytology Reviewed
Ikeda K, Oboshi W, Hashimoto Y, Komene T, Yamaguchi Y, Sato S, Maruyama S, Furukawa N, Sakabe N, Nagata K
Acta Cytologica Vol. 66 ( 1 ) page： 55 - 60 2021.10
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Surgical ablation of whitened interscapular brown fat ameliorates cardiac pathology in salt-loaded metabolic syndrome rats Reviewed
Komatsu Y, Aoyama K, Yoneda M, Ito S, Sano Y, Kawai Y, Cui X, Yamada Y, Furukawa N, Ikeda K, Nagata K
Annals of the New York Academy of Sciences Vol. 1492 ( 1 ) page： 11 - 26 2021.5
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The prebiotic fiber inulin ameliorates cardiac, adipose tissue, and hepatic pathology but exacerbates hypertriglyceridemia in rats with metabolic syndrome Reviewed
Komatsu Y, Aoyama K, Yoneda M, Ashikawa S, Nakano S, Kawai Y, Cui X, Furukawa N, Ikeda K, Nagata K
American Journal of Physiology Heart and Circulatory Physiology Vol. 320 ( 1 ) page： H281-H295 2021.1
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Alleviation of salt-induced exacerbation of cardiac, renal, and visceral fat pathology in rats with metabolic syndrome by surgical removal of subcutaneous fat Reviewed
Aoyama K, Komatsu Y, Yoneda M, Nakano S, Ashikawa S, Kawai Y, Cui X, Ikeda K, Nagata K
Nutrition & Diabetes Vol. 10 ( 1 ) page： 28 2020.8
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次世代リーダーを育成するための臨床検査技師教育のあるべき姿とそれに向けた取組み―国立大学の立場から Invited
永田浩三
臨床検査技師教育 Vol. 11 ( 1 ) page： 73-77 2019.3
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Overexpression of collagen type III in injured myocardium prevents cardiac systolic dysfunction by changing the balance of collagen distribution Reviewed
Uchinaka A, Yoshida M, Tanaka K, Hamada Y, Mori S, Maeno Y, Miyagawa S, Sawa Y, Nagata K, Yamamoto H, Kawaguchi N
The Journal of Thoracic and Cardiovascular Surgery Vol. 156 ( 1 ) page： 217-226 2018.7
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Effects of ramelteon on cardiac injury and adipose tissue pathology in rats with metabolic syndrome Reviewed
Uchinaka A, Kawashima Y, Sano Y, Ito S, Sano Y, Nagasawa K, Matsuura N, Yoneda M, Yamada Y, Murohara T, Nagata K
Annals of the New York Academy of Sciences Vol. 1421 ( 1 ) page： 73-87 2018.6
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Anti-inflammatory effects of heat-killed Lactobacillus plantarum L-137 on cardiac and adipose tissue in rats with metabolic syndrome Reviewed
Uchinaka A, Azuma N, Mizumoto H, Nakano S, Minamiya M, Yoneda M, Aoyama K, Komatsu Y, Yamada Y, Murohara T, Nagata K
Scientific Reports Vol. 8 ( 1 ) page： 8156 2018.5
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Evaluation of dermal wound healing activity of synthetic peptide SVVYGLR Reviewed
Uchinaka A, Kawaguchi N, Ban T, Hamada Y, Mori S, Maeno Y, Sawa Y, Nagata K, Yamamoto H
Biochemical and Biophysical Research Communications Vol. 491 ( 3 ) page： 714-720 2017.9
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Atorvastatin reduces cardiac and adipose tissue inflammation in rats with metabolic syndrome Reviewed
Yamada Y, Takeuchi S, Yoneda M, Ito S, Sano Y, Nagasawa K, Matsuura N, Uchinaka A, Murohara T, Nagata K
International Journal of Cardiology Vol. 240 page： 332-338 2017.8
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Effects of mTOR inhibition on cardiac and adipose tissue pathology and glucose metabolism in rats with metabolic syndrome Reviewed
Uchinaka A, Yoneda M, Yamada Y, Murohara T, Nagata K
Pharmacology Research & Perspectives Vol. 5 ( 4 ) page： e00331 2017.8
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Laminin α2-secreting fibroblasts enhance the therapeutic effect of skeletal myoblast sheets Reviewed
Uchinaka A, Tasaka K, Mizuno Y, Maeno Y, Ban T, Mori S, Hamada Y, Miyagawa S, Saito A, Sawa Y, Matsuura N, Nagata K, Yamamoto H, Kawaguchi N
European Journal of Cardio-Thoracic Surgery Vol. 51 ( 3 ) page： 457-464 2017.5
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Effects of various types of anesthesia on hemodynamics, cardiac function, and glucose and lipid metabolism in rats Reviewed
Sano Y, Ito S, Yoneda M, Nagasawa K, Matsuura N, Yamada Y, Uchinaka A, Bando YK, Murohara T, Nagata K
American Journal of Physiology Heart and Circulatory Physiology Vol. 311 ( 6 ) page： H1360-H1366 2016.12
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Highly purified eicosapentaenoic acid ameliorates cardiac injury and adipose tissue inflammation in a rat model of metabolic syndrome Reviewed
Ito S, Sano Y, Nagasawa K, Matsuura N, Yamada Y, Uchinaka A, Murohara T, Nagata K
Obesity Science & Practice Vol. 2 ( 3 ) page： 318-329 2016.9
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Attenuation of cold stress-induced exacerbation of cardiac and adipose tissue pathology and metabolic disorders in a rat model of metabolic syndrome by the glucocorticoid receptor antagonist RU486 Reviewed
Nagasawa K, Matsuura N, Takeshita Y, Ito S, Sano Y, Yamada Y, Uchinaka A, Murohara T, Nagata K
Nutrition & Diabetes Vol. 6 page： e207 2016.4
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Blockade of glucocorticoid receptors with RU486 attenuates cardiac damage and adipose tissue inflammation in a rat model of metabolic syndrome Reviewed
Takeshita Y, Watanabe S, Hattori T, Nagasawa K, Matsuura N, Takahashi K, Murohara T, Nagata K
Hypertension Research Vol. 38 ( 11 ) page： 741-750 2015.11
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Restraint stress exacerbates cardiac and adipose tissue pathology via β-adrenergic signaling in rats with metabolic syndrome Reviewed
Matsuura N, Nagasawa K, Minagawa Y, Ito S, Sano Y, Yamada Y, Hattori T, Watanabe S, Murohara T, Nagata K
American Journal of Physiology Heart and Circulatory Physiology Vol. 308 ( 10 ) page： H1275-H1286 2015.5
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Roles of oxidative stress and the mineralocorticoid receptor in cardiac pathology in a rat model of metabolic syndrome Reviewed
Takahashi K, Murase T, Takatsu M, Matsuura N, Nagasawa K, Hattori T, Watanabe S, Murohara T, Nagata K
Nagoya Journal of Medical Science Vol. 77 ( 1-2 ) page： 275-289 2015.2
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Effects of pioglitazone on cardiac and adipose tissue pathology in rats with metabolic syndrome Reviewed
Matsuura N, Asano C, Nagasawa K, Ito S, Sano Y, Minagawa Y, Yamada Y, Hattori T, Watanabe S, Murohara T, Nagata K
International Journal of Cardiology Vol. 179 page： 360-369 2015.1
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Comparative effects of valsartan in combination with cilnidipine or amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats Reviewed
Nagasawa K, Takahashi K, Matsuura N, Takatsu M, Hattori T, Watanabe S, Harada E, Niinuma K, Murohara T, Nagata K
Hypertension Research Vol. 38 ( 1 ) page： 39-47 2015.1
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Dietary salt restriction improves cardiac and adipose tissue pathology independently of obesity in a rat model of metabolic syndrome Reviewed
Hattori T, Murase T, Takatsu M, Nagasawa K, Matsuura N, Watanabe S, Murohara T, Nagata K
Journal of the American Heart Association Vol. 3 ( 6 ) page： e001312 2014.12
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Elevated C-reactive protein levels and enhanced high frequency vasomotion in patients with ischemic heart disease during brachial flow-mediated dilation Reviewed
Watanabe S, Amiya E, Watanabe M, Takata M, Ozeki A, Watanabe A, Kawarasaki S, Nakao T, Hosoya Y, Nagata K, Nagai R, Komuro I
PLoS One Vol. 9 ( 10 ) page： e110013 2014.10
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Generation of rat-induced pluripotent stem cells from a new model of metabolic syndrome Reviewed
Takenaka-Ninagawa N, Kawabata Y, Watanabe S, Nagata K, Torihashi S
PLoS One Vol. 9 ( 8 ) page： e104462 2014.8
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Premature cardiac senescence in DahlS.Z-Leprfa/Leprfa rats as a new animal model of metabolic syndrome Reviewed
Takahashi K, Takatsu M, Hattori T, Murase T, Ohura S, Takeshita Y, Watanabe S, Murohara T, Nagata K
Nagoya Journal of Medical Science Vol. 76 ( 1-2 ) page： 35-49 2014.2
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Glucocorticoids activate cardiac mineralocorticoid receptors in adrenalectomized Dahl salt-sensitive rats Reviewed
Ohtake M, Hattori T, Murase T, Takahashi K, Takatsu M, Ohtake M, Miyachi M, Watanabe S, Cheng XW, Murohara T, Nagata K
Nagoya Journal of Medical Science Vol. 76 ( 1-2 ) page： 59-72 2014.2
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Effects of salt status and blockade of mineralocorticoid receptors on aldosterone-induced cardiac injury Reviewed
Hattori T, Murase T, Sugiura Y, Nagasawa K, Takahashi K, Ohtake M, Ohtake M, Miyachi M, Murohara T, Nagata K
Hypertension Research Vol. 37 ( 2 ) page： 125-133 2014.2
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Calorie restriction attenuates cardiac remodeling and diastolic dysfunction in a rat model of metabolic syndrome Reviewed
Takatsu M, Nakashima C, Takahashi K, Murase T, Hattori T, Ito H, Murohara T, Nagata K
Hypertension Vol. 62 ( 5 ) page： 957-965 2013.11
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Effects of aged garlic extract on left ventricular diastolic function and fibrosis in a rat hypertension model Reviewed
Hara Y, Noda A, Miyata S, Minoshima M, Sugiura M, Kojima J, Otake M, Furukawa M, Cheng XW, Nagata K, Murohara T
Experimental Animals Vol. 62 ( 4 ) page： 305-310 2013.10
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Glucocorticoid-induced hypertension and cardiac injury: effects of mineralocorticoid and glucocorticoid receptor antagonism Reviewed
Hattori T, Murase T, Iwase E, Takahashi K, Ohtake M, Tsuboi K, Ohtake M, Miyachi M, Murohara T, Nagata K
Nagoya Journal of Medical Science Vol. 75 ( 1,2 ) page： 81-92 2013.2
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新規メタボリック症候群ラットモデルを用いた高頻度対低頻度の運動トレーニングの心血管効果の比較検討 Reviewed
中島千恵子、高津美和、杉山大輔、辻村杏理沙、村井翔太郎、矢島美希、高橋圭司、村瀬珠代、服部拓哉、加藤洋介、室原豊明、永田浩三
心臓 Vol. 45 ( 2 ) page： 147-158 2013.2
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循環器専門医が考える高血圧合併症のリスク管理（高血圧と心肥大形成・心不全発症）―心肥大を呈する高血圧におけるCa拮抗薬の心保護効果― Invited
永田浩三
循環plus Vol. 13 ( 4 ) page： 7-9 2013.1
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Dipeptidyl Peptidase-4 Modulates Left Ventricular Dysfunction in Chronic Heart Failure via Angiogenesis-Dependent and -Independent Actions Reviewed
Shigeta T, Aoyama M, Bando YK, Monji A, Mitsui T, Takatsu M, Cheng XW, Okumura T, Hirashiki A, Nagata K, Murohara T
Circulation Vol. 126 ( 15 ) page： 1838-1851 2012.10
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Comparison of the effects of cilnidipine and amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats Reviewed
Takatsu M, Hattori T, Murase T, Ohtake M, Kato M, Nashima K, Nakashima C, Takahashi K, Ito H, Niinuma K, Aritomi S, Murohara T, Nagata K
Journal of Hypertension Vol. 30 ( 9 ) page： 1845-55 2012.9
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Effects of estrogen on cardiovascular injury in ovariectomized female DahlS.Z-Leprfa/Leprfa rats as a new animal model of metabolic syndrome (An editorial commentary published by the journal) Reviewed
Murase T, Hattori T, Ohtake M, Nakashima C, Takatsu M, Murohara T, Nagata K
Hypertension Vol. 59 ( 3 ) page： 694-704 2012.3
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Cardiac remodeling and diastolic dysfunction in DahlS.Z-Leprfa/Leprfa rats: a new animal model of metabolic syndrome Reviewed
Murase T, Hattori T, Ohtake M, Abe M, Amakusa Y, Takatsu M, Murohara T, Nagata K
Hypertension Research Vol. 35 ( 2 ) page： 186-93 2012.2
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Angiotensin-converting enzyme inhibition promotes coronary angiogenesis in the failing heart of Dahl salt-sensitive hypertensive rats Reviewed
Yazawa H, Miyachi M, Furukawa M, Takahashi K, Takatsu M, Tsuboi K, Ohtake M, Murase T, Hattori T, Kato Y, Murohara T, Nagata K
Journal of Cardiac Failure Vol. 17 ( 12 ) page： 1041-1050 2011.12
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Cardioprotective mechanisms of lifestyle modifications and pharmacotherapies on cardiac remodeling and dysfunction in hypertensive heart disease: An overview Invited Reviewed
Nagata K, Hattori T
Nagoya Journal of Medical Science Vol. 73 ( 3-4 ) page： 91-105 2011.8
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Mechanism underlying the efficacy of combination therapy with losartan and hydrochlorothiazide in rats with salt-sensitive hypertension Reviewed
Yamada Y, Tsuboi K, Hattori T, Murase T, Ohtake M, Furukawa M, Ueyama J, Nishiyama A, Murohara T, Nagata K
Hypertension Research Vol. 34 ( 7 ) page： 809-816 2011.7
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Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Leprfa/Leprfa rat Reviewed
Hattori T, Murase T, Ohtake M, Inoue T, Tsukamoto H, Takatsu M, Kato Y, Hashimoto K, Murohara T, Nagata K
Nutrition and Diabetes Vol. 1 page： e1 2011.1
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Ca2+ channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats Reviewed
Nishizawa T, Cheng XW, Jin Z, Obata K, Nagata K, Hirashiki A, Sasaki T, Noda A, Takeshita K, Izawa H, Shi GP, Kuzuya M, Okumura K, Murohara T
Journal of Hypertension Vol. 28 ( 7 ) page： 1515-26 2010.7
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Adiponectin acts as a positive indicator of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy Reviewed
Unno K, Shibata R, Izawa H, Hirashiki A, Murase Y, Yamada T, Kobayashi M, Noda A, Nagata K, Ouchi N, Murohara T, Murohara T
Heart Vol. 96 ( 5 ) page： 357-361 2010.3
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Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population Reviewed
Asano H, Izawa H, Nagata K, Nakatochi M, Kobayashi M, Hirashiki A, Shintani S, Nishizawa T, Tanimura D, Naruse K, Matsubara T, Murohara T, Yokota M
Diabetologia Vol. 53 ( 2 ) page： 234-246 2010.2
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Beneficial effects of growth hormone-releasing peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters Reviewed
Kato Y, Iwase M, Ichihara S, Kanazawa H, Hashimoto K, Noda A, Nagata K, Koike Y, Yokota M
Circulation Journal Vol. 74 ( 1 ) page： 163-170 2010.1
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Evidence for the importance of adiponectin in the cardioprotective effects of pioglitazone Reviewed
Li P, Shibata R, Unno K, Shimano M, Furukawa M, Ohashi T, Cheng X, Nagata K, Ouchi N, Murohara T
Hypertension Vol. 55 ( 1 ) page： 69-75 2010.1
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Mutation of ARHGAP9 in patients with coronary spastic angina Reviewed
Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K
Journal of Human Genetics Vol. 55 ( 1 ) page： 42-49 2010.1
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Endomyocardial Radial Strain Imaging and Left Ventricular Relaxation Abnormalities in Patients With Hypertrophic Cardiomyopathy or Hypertensive Left Ventricular Hypertrophy Reviewed
Minoshima M, Noda A, Nishizawa T, Hara Y, Sugiura M, Iino S, Nagata K, Koike Y, Murohara T
Circulation Journal Vol. 73 ( 12 ) page： 2294-2299 2009.12
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Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats Reviewed
Yamada T, Nagata K, Cheng XW, Obata K, Saka M, Miyachi M, Naruse K, Nishizawa T, Noda A, Izawa H, Kuzuya M, Okumura K, Murohara T, Yokota M
European Journal of Pharmacology Vol. 615 ( 1-3 ) page： 163-170 2009.8
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Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy Reviewed
Unno K, Isobe S, Izawa H, Cheng XW, Kobayashi M, Hirashiki A, Yamada T, Harada K, Ohshima S, Noda A, Nagata K, Kato K, Yokota M, Murohara T
European Heart Journal Vol. 30 ( 15 ) page： 1853-1862 2009.8
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Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers Reviewed
Cheng XW, Okumura K, Kuzuya M, Jin Z, Nagata K, Obata K, Inoue A, Hirashiki A, Takeshita K, Unno K, Harada K, Shi GP, Yokota M, Murohara T
Journal of Cardiovascular Pharmacology Vol. 54 ( 1 ) page： 47-56 2009.7
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Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or mildly symptomatic patients with heart failure: comparison with azosemide Reviewed
Harada K, Izawa H, Nishizawa T, Hirashiki A, Murase Y, Kobayashi M, Isobe S, Cheng XW, Noda A, Nagata K, Yokota M, Murohara T
Journal of Cardiovascular Pharmacology Vol. 53 ( 6 ) page： 468-473 2009.6
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Response to exercise generates lactate and fluid intake; effects on mitochondrial function in heart and vascular smooth muscle Invited Reviewed
Miyachi M, Nagata K
Hypertension Vol. 54 page： e15 2009.6
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Exercise training alters left ventricular geometry and attenuates heart failure in Dahl salt-sensitive hypertensive rats (An editorial commentary published by the journal) Reviewed
Miyachi M, Yazawa H, Furukawa M, Tsuboi K, Ohtake M, Nishizawa T, Hashimoto K, Yokoi T, Kojima T, Murate T, Yokota M, Murohara T, Koike Y, Nagata K
Hypertension Vol. 53 ( 4 ) page： 701-707 2009.4
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Dobutamine stress testing as a diagnostic tool for evaluation of myocardial contractile reserve in asymptomatic or mildly symptomatic patients with dilated cardiomyopathy Reviewed
Kobayashi M, Izawa H, Cheng XW, Asano H, Hirashiki A, Unno K, Ohshima S, Yamada T, Murase Y, Kato TS, Obata K, Noda A, Nishizawa T, Isobe S, Nagata K, Matsubara T, Murohara T, Yokota M
JACC: Cardiovascular Imaging Vol. 1 ( 6 ) page： 718-726 2008.11
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Heterogeneity of regional systolic function detected by tissue doppler imaging is linked to impaired global left ventricular relaxation in hypertrophic cardiomyopathy
Kato TS, Izawa H, Komamura K, Noda A, Asano H, Nagata K, Hashimoto S, Oda N, Kamiya C, Kanzaki H, Hashimura K, Nakatani T, Ueda HI, Murohara T, Kitakaze M, Yokota M
Heart Vol. 94 ( 10 ) page： 1302-1306 2008.10
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Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment Reviewed
Cheng XW, Murohara T, Kuzuya M, Izawa H, Sasaki T, Obata K, Nagata K, Nishizawa T, Kobayashi M, Yamada T, Kim W, Sato K, Shi GP, Okumura K, Yokota M
American Journal of Pathology Vol. 173 ( 2 ) page： 358-369 2008.8
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Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt Reviewed
Kato MF, Shibata R, Obata K, Miyachi M, Yazawa H, Tsuboi K, Yamada T, Nishizawa T, Noda A, Cheng XW, Murate T, Koike Y, Murohara T, Yokota M, Nagata K
Journal of Hypertension Vol. 26 ( 8 ) page： 1669-1676 2008.8
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Mineralocorticoid antagonism and cardiac hypertrophy Invited Reviewed
Nagata K
Current Hypertension Reports Vol. 10 ( 3 ) page： 216-221 2008.6
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Molecular defects associated with antithrombin deficiency and dilated cardiomyopathy in a Japanese patient Reviewed
Fujimori Y, Okimatsu H, Kashiwagi T, Sanda N, Okumura K, Takagi A, Nagata K, Murate T, Uchida A, Node K, Saito H, Kojima T
Internal Medicine Vol. 47 ( 10 ) page： 925-931 2008.5
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Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters Reviewed
Hayashi K, Kimata H, Obata K, Matsushita A, Fukata A, Hashimoto K, Noda A, Iwase M, Koike Y, Yokota M, Nagata K
Journal of Cardiac Failure Vol. 14 ( 3 ) page： 238-244 2008.4
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Aldosterone modulates If current through gene expression in cultured neonatal rat ventricular myocytes Reviewed
Muto T, Ueda N, Opthof T, Ohkusa T, Nagata K, Suzuki S, Tsuji Y, Horiba M, Lee JK, Honjo H, Kamiya K, Kodama I, Yasui K
American Journal of Physiology Heart and Circulatory Physiology Vol. 293 ( 5 ) page： H2710-H2718 2007.11
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Wilms' tumor 1 message and protein expression in bone marrow failure syndrome and acute leukemia Reviewed
Iwasaki T, Sugisaki C, Nagata K, Takagi K, Takagi A, Kojima T, Ito M, Nakamura S, Naoe T, Murate T
Pathology International Vol. 57 ( 10 ) page： 645-651 2007.10
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Differential cardiovascular effects of endotoxin derived from Escherichia coli or Pseudomonas aeruginosa Reviewed
Matsushita A, Iwase M, Kato Y, Ichihara S, Ichihara G, Kimata H, Hayashi K, Hashimoto K, Yokoi T, Noda A, Koike Y, Yokota M, Nagata K
Experimental Animals Vol. 56 ( 5 ) page： 339-348 2007.10
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Diversity of the elevation of serum cardiac troponin I levels in patients during their first visit to the emergency room Reviewed
Saiki A, Iwase M, Takeichi Y, Umeda H, Ishiki R, Inagaki H, Kato Y, Nagata K, Koike Y
Circulation Journal Vol. 71 ( 9 ) page： 1458-1462 2007.9
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Continuous positive airway pressure improves daytime baroreflex sensitivity and nitric oxide production in patients with moderate to severe obstructive sleep apnea syndrome Reviewed
Noda A, Nakata S, Koike Y, Miyata S, Kitaichi K, Nishizawa T, Nagata K, Yasuma F, Murohara T, Yokota M
Hypertension Research Vol. 30 ( 8 ) page： 669-676 2007.8
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Beneficial effect of bilevel positive airway pressure on left ventricular function in ambulatory patients with idiopathic dilated cardiomyopathy and central sleep apnea-hypopnea: a preliminary study Reviewed
Noda A, Izawa H, Asano H, Nakata S, Hirashiki A, Murase Y, Iino S, Nagata K, Murohara T, Koike Y, Yokota M
Chest Vol. 131 ( 6 ) page： 1694-1701 2007.6
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Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway Reviewed
Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Noda A, Izawa H, Nagata K, Yokota M
Clinical and Experimental Pharmacology and Physiology Vol. 33 ( 12 ) page： 1164-1171 2006.12
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Differential myolysis of myocardium and skeletal muscle in hamsters with dilated cardiomyopathy Reviewed
Kato Y, Iwase M, Takagi K, Nishizawa T, Kanazawa H, Matsushita A, Umeda H, Izawa H, Noda A, Koike Y, Nagata K, Yokota M
Circulation Journal Vol. 70 ( 11 ) page： 1497-1502 2006.11
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Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure Reviewed
Cheng XW, Obata K, Kuzuya M, Izawa H, Nakamura K, Asai E, Nagasaka T, Saka M, Kimata T, Noda A, Nagata K, Jin H, Shi GP, Iguchi A, Murohara T, Yokota M
Hypertension Vol. 48 ( 5 ) page： 979-987 2006.11
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Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes Reviewed
Sobue S, Iwasaki T, Sugisaki C, Nagata K, Kikuchi R, Murakami M, Takagi A, Kojima T, Banno Y, Akao Y, Nozawa Y, Kannagi R, Suzuki M, Abe A, Naoe T, Murate T
Leukemia Vol. 20 ( 11 ) page： 2042-2046 2006.11
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Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors Reviewed
Ichihara S, Obata K, Yamada Y, Nagata K, Noda A, Ichihara G, Yamada A, Kato T, Izawa H, Murohara T, Yokota M
Journal of Molecular and Cellular Cardiology Vol. 41 ( 2 ) page： 318-329 2006.8
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狭心症治療薬ニコランジルの多面的効果 Invited
永田浩三，小畑孝ニ，横田充弘
循環器科 Vol. 60 ( 2 ) page： 148-156 2006.8
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Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure Reviewed
Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Nishizawa T, Noda A, Izawa H, Nagata K, Murohara T, Yokota M
Journal of Cardiovascular Pharmacology Vol. 47 ( 6 ) page： 770-779 2006.6
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Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats (An editorial commentary published by the journal) Reviewed
Nagata K, Obata K, Xu J, Ichihara S, Noda A, Kimata H, Kato T, Izawa H, Murohara T, Yokota M
Hypertension Vol. 47 ( 4 ) page： 656-664 2006.4
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Prognostic value of pacing-induced mechanical alternans in patients with mild-to-moderate idiopathic dilated cardiomyopathy in sinus rhythm Reviewed
Hirashiki A, Izawa H, Somura F, Obata K, Kato T, Nishizawa T, Yamada A, Asano H, Ohshima S, Noda A, Iino S, Nagata K, Okumura K, Murohara T, Yokota M
Journal of the American College of Cardiology Vol. 47 ( 7 ) page： 1382-1389 2006.4
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The distal protection during primary percutaneous coronary intervention alleviates the adverse effects of large thrombus burden on myocardial reperfusion Reviewed
Umeda H, Katoh T, Iwase M, Izawa H, Nagata K, Watanabe K, Okada T, Yamada T, Tani T, Matsushita T, Murakami Y, Okamoto M, Shimizu T, Murohara T, Yokota M
Circulation Journal Vol. 70 ( 3 ) page： 232-238 2006.3
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Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure Reviewed
Ichihara S, Noda A, Nagata K, Obata K, Xu J, Ichihara G, Oikawa S, Kawanishi S, Yamada Y, Yokota M
Cardiovascular Research Vol. 69 ( 3 ) page： 726-735 2006.2
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Overexpression of calmodulin induces cardiac hypertrophy by a calcineurin-dependent pathway Reviewed
Koji Obata, Kohzo Nagata, Mitsunori Iwase, Mari Odashima, Tetsuro Nagasaka, Hideo Izawa, Toyoaki Murohara, Yoshiji Yamada, Mitsuhiro Yokota
Biochemical and Biophysical Research Communications Vol. 338 ( 2 ) page： 1299-1305 2005.12
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Cardiac sympathetic dysfunction correlates with abnormal myocardial contractile reserve in dilated cardiomyopathy patients Reviewed
Satoru Ohshima, Satoshi Isobe, Hideo Izawa, Mamoru Nanasato, Akitada Ando, Akira Yamada, Kiyoyasu Yamada, Tomoko Kato, Koji Obata, Akiko Noda, Takao Nishizawa, Katsuhiko Kato, Kohzo Nagata, Kenji Okumura, Toyoaki Murohara, Mitsuhiro Yokota
Journal of the American College of Cardiology Vol. 46 ( 11 ) page： 2061-2068. 2005.12
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Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study Reviewed
Izawa H, Murohara T, Nagata K, Isobe S, Asano H, Amano T, Ichihara S, Kato T, Ohshima S, Murase Y, Iino S, Obata K, Noda A, Okumura K, Yokota M
Circulation Vol. 112 ( 19 ) page： 2940-2945 2005.11
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Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats (An editorial commentary published by the journal) Reviewed
Jinglan Xu, Kohzo Nagata, Koji Obata, Sahoko Ichihara, Hideo Izawa, Akiko Noda, Tetsuro Nagasaka, Mitsunori Iwase, Toyoaki Murohara, Mitsuhiro Yokota
Hypertension Vol. 46 ( 4 ) page： 719-24 2005.10
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Cardiac 123I-MIBG reflects left ventricular functional reserve in patients with nonobstructive hypertrophic cardiomyopathy Reviewed
Satoshi Isobe, Hideo Izawa, Mitsunori Iwase, Mamoru Nanasato, Makoto Nonokawa, Akitada Ando, Satoru Ohshima, Kohzo Nagata, Katsuhiko Kato, Takao Nishizawa, Toyoaki Murohara, Mitsuhiro Yokota
Journal of Nuclear Medicine Vol. 46 ( 6: ) page： 909-916 2005.6
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Discrimination of nonobstructive hypertrophic cardiomyopathy from hypertensive left ventricular hypertrophy on the basis of strain rate imaging by tissue Doppler ultrasonography Reviewed
Tomoko S. Kato, Akiko Noda, Hideo Izawa, Akira Yamada, Koji Obata, Kohzo Nagata, Mitsunori Iwase, Toyoaki Murohara, Mitsuhiro Yokota
Circulation Vol. 110 ( 25 ) page： 3808-3814 2004.12
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Serial alterations of β-adrenergic signaling in dilated cardiomyopathic hamsters: possible role of myocardial oxidative stress Reviewed
Takao Nishizawa, Mitsunori Iwase, Hiroaki Kanazawa, Sahoko Ichihara, Gaku Ichihara, Kohzo Nagata, Koji Obata, Kiyoyuki Kitaichi, Toyoharu Yokoi, Masato Watanabe, Takashi Tsunematsu, Yoshihiro Ishikawa, Toyoaki Murohara, Mitsuhiro Yokota
Circulation Journal Vol. 68 ( 11 ) page： 1051-1060 2004.11
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Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese Reviewed
Akira Yamada, Sahoko Ichihara, Yosuke Murase, Tomoko Kato, Hideo Izawa, Kohzo Nagata, Toyoaki Murohara, Yoshiji Yamada, Mitsuhiro Yokota
Journal of Molecular Medicine Vol. 82 ( 7 ) page： 477-483 2004.7
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Blunt circulatory response to exercise in coronary high-risk subjects among apparently healthy Japanese Reviewed
Ichihara Y, Ohno J, Suzuki M, Anno T, Sugino M, Nagata K
Circulation Journal Vol. 68 ( 4 ) page： 286-293 2004.4
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Promising efficacy of primary gradual and prolonged balloon angioplasty in small coronary arteries: A randomized comparison with cutting balloon angioplasty and conventional balloon angioplasty Reviewed
Umeda H, Iwase M, Kanda H, Izawa H, Nagata K, Ishiki R, Sawada K, Murohara T, Yokota M
American Heart Journal Vol. 147 ( 1 ) page： E4 2004.1
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Growth hormone-releasing peptide can improve left ventricular dysfunction and attenuate dilation in dilated cardiomyopathic hamsters Reviewed
Iwase M, Kanazawa H, Kato Y, Nishizawa T, Somura F, Ishiki R, Nagata K, Hashimoto K, Takagi K, Izawa H, Yokota M
Cardiovascular Research Vol. 61 ( 1 ) page： 30-38 2004.1
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Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia Reviewed
Keiko Shimokata, Yoshiji Yamada, Takahisa Kondo, Sahoko Ichihara, Hideo Izawa, Kohzo Nagata, Toyoaki Murohara, Miyoshi Ohno, Mitsuhiro Yokota
Atherosclerosis Vol. 172 ( 1 ) page： 167-173 2004.1
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Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through activation of mitochondrial ATP-sensitive potassium channels and a nitrate-like effect
Nagata K, Obata K, Odashima M, Yamada A, Somura F, Nishizawa T, Ichihara S, Izawa H, Iwase M, Hayakawa A, Murohara T, Yokota M
Journal of Molecular and Cellular Cardiology Vol. 35 ( 12 ) page： 1505-1512 2003.12
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成人病と生活習慣病：循環器疾患の非薬物治療―現状と今後の展開―心筋の再生治療 Invited
永田浩三，横田充弘，室原豊明
成人病と生活習慣病 Vol. 33 ( 8 ) page： 931-935 2003.8
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Biphasic relaxation-frequency relations in patients with effort angina pectoris: a new marker of myocardial demand ischemia Reviewed
Hisashi Umeda,Mitsunori Iwase,Hideo Izawa,Takao Nishizawa,Makoto Nonokawa,Satoshi Isobe,Akiko Noda,Kohzo Nagata,Hitoshi Ishihara,Mitsuhiro Yokota
American Heart Journal Vol. 146 ( 1 ) page： 75-83 2003.7
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Validity and application of noninvasive measurement of blood pressure in hamsters Reviewed
Yosuke Kato,Mitsunori Iwase,Hiroaki Kanazawa,Takao Nishizawa,Ying Lan Zhao,Kenji Takagi,Kohzo Nagata,Akiko Noda,Yasuo Koike,Mitsuhiro Yokota
Experimental Animals Vol. 52 ( 4 ) page： 359-363 2003.7
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Myocardial velocity gradient as a noninvasively determined index of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy Reviewed
Tomoko Kato,Akiko Noda,Hideo Izawa,Takao Nishizawa,Fuji Somura,Akira Yamada,Kohzo Nagata,Mitsunori Iwase,Akimasa Nakao,Mitsuhiro Yokota
Journal of the American College of Cardiology Vol. 42 ( 2 ) page： 278-285 2003.7
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Effect of nicorandil on left ventricular end-diastolic pressure during exercise in patients with hypertrophic cardiomyopathy Reviewed
Hideo Izawa,Mitsunori Iwase,Yasushi Takeichi,Fuji Somura,Kohzo Nagata,Takao Nishizawa,Akiko Noda,Toyoaki Murohara,Mitsuhiro Yokota
European Heart Journal Vol. 24 ( 14 ) page： 1340-1348 2003.7
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AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats Reviewed
Nagata K, Somura F, Obata K, Odashima M, Izawa H, Ichihara S, Nagasaka T, Iwase M, Yamada Y, Nakashima N, Yokota M
Hypertension Vol. 40 ( 2 ) page： 168-174 2002.8
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Higher C-reactive protein concentration and white blood cell count in subjects with more coronary risk factors and/or lower physical fitness among apparently healthy Japanese
Ichihara Y, Ohno J, Suzuki M, Anno T, Sugino M, Nagata K
Circulation Journal Vol. 66 ( 7 ) page： 677-684 2002.7
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Effects of FK506 and rapamycin on formation of the neural tube in chick embryos Reviewed
Koji Obata,Masafumi Koide,Kohzo Nagata,Akio Iio,Shigenobu Yazawa,Tamao Ono,Shin-ichi Sasaki,Yoshiji Yamada,Rocky S.Tuan,Mitsuhiro Yokota
Animal Science Journal Vol. 73 ( 3 ) page： 229-234 2002.6
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Prognostic value of mechanical efficiency in ambulatory patients with idiopathic cardiomyopathy in sinus rhythm Reviewed
Il Sung Kim,Hideo Izawa,Toshikazu Sobue,Hitoshi Ishihara,Fuji Somura,Takao Nishizawa,Kohzo Nagata,Mitsunori Iwase,Mitsuhiro Yokota
Journal of the American College of Cardiology Vol. 39 ( 8 ) page： 1264-1268 2002.4
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Biphasic changes in left ventricular end-diastolic pressure during dynamic exercise in patients with nonobstructive hypertrophic cardiomyopathy Reviewed
Yasushi Takeichi,Mitsuhiro Yokota,Mitsunori Iwase,Hideo Izawa,Takao Nishizawa,Ryoji Ishiki,Fuji Somura,Kohzo Nagata,Satoshi Isobe,Akiko Noda
Journal of the American College of Cardiology Vol. 38 ( 2 ) page： 335-343 2001.8
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Reduced myocardial sarcoplasmic reticulum Ca2+-ATPase mRNA expression and biphasic force-frequency relations in patients with hypertrophyc cardiomyopathy Reviewed
Fuji Somura,Hideo Izawa,Mitsunori Iwase,Yasushi Takeichi,Ryoji Ishiki,Takao Nishizawa,Akiko Noda,Kohzo Nagata,Yoshiji Yamada,Mitsuhiro Yokota
Circulation Vol. 104 ( 6 ) page： 658-663 2001.8
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Role of FK506-binding protein 12 in development of the chick embryonic heart Reviewed
Koji Obata,Masafumi Koide,Kohzo Nagata,Akio Iio,Shigenobu Yazawa,Tamao Ono,Yoshiji Yamada,Rocky S.Tuan,Mitsuhiro Yokota
Biochemical and Biophysical Research Communications Vol. 283 ( 3 ) page： 613-620 2001.5
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Targeted inactivation of Gαi does not alter cardiac function or β-adrenergic sensitivity Reviewed
Jain M, Lim CC, Nagata K, Davis VM, Milstone DS, Liao R, Mortensen RM
American Journal of Physiology Heart and Circulatory Physiology Vol. 280 ( 2 ) page： H569-H575 2001.2
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Gαi2 but not Gαi3 is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes Reviewed
Nagata K, Ye C, Jain M, Milstone DS, Liao R, Mortensen RM
Circulation Research Vol. 87 ( 10 ) page： 903-909 2000.11
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Altered β-adrenergic signal transduction in nonfailing hypertrophied myocytes from Dahl salt-sensitive rats Reviewed
Nagata K, Communal C, Lim CC, Jain M, Suter TM, Eberli FR, Satoh N, Colucci WS, Apstein CS, Liao R
American Journal of Physiology Heart and Circulatory Physiology Vol. 279 ( 5 ) page： H2502-H2508. 2000.11
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Different β-adrenergic regulation of myocardial contraction and relaxation between apical and nonobstructive hypertrophic cardiomyopathy Reviewed
Ping Zuo,Hideo Izawa,Ryoji Ishiki,Akiko Noda,Takao Nishizawa,Kazushige Shigemura,Kohzo Nagata,Mitsunori Iwase,Mitsuhiro Yokota
American Heart Journal Vol. 140 ( 2 ) page： 329-337 2000.8
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Acute effects of a single low oral dose of pimobendan on left ventricular systolic and diastolic function in patients with congestive heart failure Reviewed
Ryoji Ishiki,Hitoshi Ishihara,Hideo Izawa,Kohzo Nagata,Makoto Hirai,Mitsuhiro Yokota
Journal of Cardiovascular Pharmacology Vol. 35 ( 6 ) page： 897-905 2000.6
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Impaired force- frequency relations in patients with hypertensive left ventricular hypertrophy. : A possible physiological marker of the trnsition from physiologica to pathological hypertrophy Reviewed
Masafumi Inagaki,Mitsuhiro Yokota,Hideo Izawa,Ryoji Ishiki,Kohzo Nagata,Mitsunori Iwase,Yoshiji Yamada,Masafumi Koide,Toshikazu Sobue
Circulation Vol. 274 ( 14 ) page： 1822-1830 1999.4
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Early changes in excitation-contraction coupling: transition from compensated hypertrophy to failure in Dahl salt-sensitive rat myocytes Reviewed
Nagata K, Liao R, Eberli FR, Satoh N, Chevalier B, Apstein CS, Suter TM
Cardiovascular Research Vol. 37 ( 2 ) page： 467-477 1998.2
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Dynamic exercise-induced changes in diastolic properties of the regional myocarduium in hypertensive left ventricular hypertrophy Reviewed
Yasushi Takeichi,Kohzo Nagata,Hideo Izawa,Mitsunori Iwase,Toshikazau Sobue,Motoaki Sugawara,Mitsuhiro Yokota
Heart and Vessels Vol. Suppl.12 page： 138-141 1997.12
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Adrenergic control of the force-frequency and relaxation-frequency relations in patients with hypertrophic cardiomyopathy Reviewed
Hideo Izawa,Mitsuhiro Yokota,Yasushi Takeichi,Masafumi Inagaki,Kohzo Nagata,Mitsunori Iwase,Toshikazu Sobue
Circulation Vol. 96 ( 9 ) page： 2959-2968 1997.11
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Effect of dobutamine and OPC-18790 on diastolic chamber stiffness in patients with idiopathic dilated cardiomyopathy Reviewed
Takeshi Machii,Mitsuhiro Yokota,Kohzo Nagata,Hitoshi Ishihara,Mitsunori Iwase,Toshikazu Sobue
Journal of Cardiovascular Pharmacology Vol. 29 ( 2 ) page： 265-272 1997.2
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Impaired response of left ventricular relaxation to exercise-induced adrenergic stimulation in patients with hypertrophic cardiomyopathy Reviewed
Hideo Izawa,Mitsuhiro Yokota,Kohzo Nagata,Mitsunori Iwase,Toshikazu Sobue
Journal of the American College of Cardiology Vol. 28 ( 7 ) page： 1738-1745 1996.12
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A novel inotropic vasodilator, OPC-18790, reduces myocardial oxygen consumption and improves mechanical efficiency with congestive heart failure Reviewed
Hirofumi Kanda,Mitsuhiro Yokota,Hitoshi Ishihara,Kohzo Nagata,Ryozo Kato,Toshikazu Sobue
American Heart Journal Vol. 132 ( 2 ) page： 361-368 1996.8
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Differential effects of dobutamine and a phosphodiesterase inhibitor on early diastolic filling in patients with congestive heart failure Reviewed
Nagata K, Iwase M, Sobue T, Yokota M
Journal of the American College of Cardiology Vol. 25 ( 2 ) page： 295-304 1995.2
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Hemodynamic effects of the calcium channel blocker pranidipine on exercise-induced angina Reviewed
Yasuto Nishinaka,Mitsuhiro Yokota,Makoto Watanabe,Toshikazu Sobue,Mitsunori Iwase,Masahiko Ukai,Akitada Ando,Kohzo Nagata,Hidehiko Saito
International Journal of Clinical Pharmacology and Therapeutics Vol. 32 ( 10 ) page： 542-549 1994.10
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－特集－「運動と心臓」 Invited
横田充弘，永田浩三
CARDIAC PRACTICE Vol. 5 ( 3 ) page： 63-68 1994.7
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Age-related changes in left and right ventricular filling velocity profiles and their relationship in normal subjects Reviewed
Mitsunori Iwase,Kozo Nagata,Hideo Izawa,Mitsuhiro Yokota, Susumu Kamihara,Haruo Inagaki,Hidehiko Saito
American Heart Journal Vol. 126 ( 2 ) page： 419-426 1993.8