Updated on 2024/03/20

写真a

 
INDEN, Yasuya
 
Organization
Graduate School of Medicine Program in Integrated Medicine Internal Medicine Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. 博士(医学)(登録番号第2925号) ( 2001.9   名古屋大学 ) 

Research Interests 3

  1. 心不全

  2. 不整脈

  3. 循環器

Research Areas 1

  1. Others / Others  / Cardiology

Education 1

  1. Nagoya University   Faculty of Medicine

    - 1988.3

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    Country: Japan

Professional Memberships 4

  1. Japanese Heart Failure Society

  2. Japanese Heart Rhythm Society

  3. The Japanese Circulation Society

  4. 日本内科学会

Awards 1

  1. 第11回 医科学応用研究財団助成による日本心電学会論文賞

    2011.9   心電学会  

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    Country:Japan

 

Papers 128

  1. Distributions and number of drivers on real-time phase mapping associated with successful atrial fibrillation termination during catheter ablation for non-paroxysmal atrial fibrillation

    Riku, S; Inden, Y; Yanagisawa, S; Fujii, A; Tomomatsu, T; Nakagomi, T; Shimojo, M; Okajima, T; Furui, K; Suga, K; Suzuki, S; Shibata, R; Murohara, T

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 67 ( 2 ) page: 303 - 317   2024.3

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  2. Comparison of novel intrinsic versus conventional antitachycardia pacing for ventricular tachycardia among implantable cardioverter-defibrillator recipients

    Yanagisawa, S; Inden, Y; Sato, Y; Watanabe, R; Goto, T; Kondo, S; Tachi, M; Iwawaki, T; Yamauchi, R; Hiramatsu, K; Shimojo, M; Tsuji, Y; Shibata, R; Murohara, T

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY     2024.2

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  3. Reply: Methodological and Mechanistic Considerations in Local Repolarization Mapping.

    Yanagisawa S, Inden Y, Tsuji Y, Shibata R, Murohara T

    JACC. Clinical electrophysiology   Vol. 10 ( 2 ) page: 378   2024.2

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    Language:English  

    DOI: 10.1016/j.jacep.2024.01.009

    PubMed

  4. Editorial to "pseudo-slow-fast atrioventricular nodal reentrant tachycardia: Is the fast pathway a criminal or innocent bystander?".

    Mizutani Y, Yanagisawa S, Inden Y

    Journal of arrhythmia   Vol. 40 ( 1 ) page: 146 - 147   2024.2

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    Language:English  

    DOI: 10.1002/joa3.12978

    PubMed

  5. Usefulness of omnipolar technology near field for accessory pathway ablation through the coronary sinus.

    Mizutani Y, Yanagisawa S, Matsumoto Y, Kanashiro M, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 10 ( 1 ) page: 92 - 95   2024.1

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    Language:English  

    DOI: 10.1016/j.hrcr.2023.10.030

    PubMed

  6. Clinical outcomes and predictors of delayed echocardiographic response to cardiac resynchronization therapy

    Tsurumi, N; Inden, Y; Yanagisawa, S; Hiramatsu, K; Yamauchi, R; Watanabe, R; Suzuki, N; Shimojo, M; Suga, K; Tsuji, Y; Murohara, T

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 35 ( 1 ) page: 97 - 110   2024.1

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  7. Triggers of Ventricular Fibrillation in Patients With Inferolateral J-Wave Syndrome

    Komatsu, Y; Nogami, A; Hocini, M; Morita, H; Sato, N; Marijon, E; Arentz, T; Yli-Maeyry, S; Onishi, Y; Kowase, S; Duchateau, J; Benali, K; Takase, T; Hosaka, Y; Takei, A; Nakajima, I; Kawamura, M; Inden, Y; Ieda, M; Aonuma, K; Haissaguerre, M

    JACC-CLINICAL ELECTROPHYSIOLOGY   Vol. 10 ( 1 ) page: 1 - 12   2024.1

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  8. Association Between Catheter Ablation for Nonparoxysmal Atrial Fibrillation and Functional Mitral Regurgitation in Patients With Heart Failure With Preserved Ejection Fraction

    Yamauchi, R; Morishima, I; Okumura, K; Kanzaki, Y; Morita, Y; Watanabe, N; Furui, K; Yoshioka, N; Shibata, N; Miyazawa, H; Shimojo, K; Imaoka, T; Sakamoto, G; Goto, H; Ohi, T; Yanagisawa, S; Inden, Y; Murohara, T

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 207   page: 192 - 201   2023.11

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  9. Visualization of Repolarization Heterogeneity in Brugada Syndrome A Quantitative Analysis of Unipolar Electrogram T-Wave

    Yanagisawa, S; Inden, Y; Goto, T; Kondo, S; Tachi, M; Iwawaki, T; Hiramatsu, K; Yamauchi, R; Shimojo, M; Tsuji, Y; Shibata, R; Murohara, T

    JACC-CLINICAL ELECTROPHYSIOLOGY   Vol. 9 ( 11 ) page: 2401 - 2411   2023.11

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  10. Elevated liver fibrosis-4 index predicts recurrence after catheter ablation for atrial fibrillation in patients with heart failure

    Iwawaki, T; Morishima, I; Kanzaki, Y; Morita, Y; Watanabe, N; Yoshioka, N; Shibata, N; Miyazawa, H; Shimojo, K; Yanagisawa, S; Inden, Y; Murohara, T

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY     2023.10

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  11. Initial multicenter clinical experience with the first-generation endoscopic guided laser balloon in Japan

    Goya, M; Hirao, K; Aonuma, K; Nogami, A; Yamane, T; Yamauchi, Y; Okishige, K; Yotsukura, A; Kimura, M; Naito, S; Kato, R; Nitta, J; Inaba, O; Satomi, K; Morita, N; Kobayashi, Y; Inden, Y; Yoshida, Y; Kakita, K; Kobori, A; Kusano, K; Inoue, K; Masuda, M; Hiroshima, K; Koyama, J; Kumagai, K; Okumura, K; HeartLight Study Investigators

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 66 ( 7 ) page: 1713 - 1721   2023.10

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  12. Lethal ventricular arrhythmia due to entrectinib-induced Brugada syndrome: a case report and literature review

    Futamura, K; Hase, T; Tanaka, A; Sakai, Y; Okachi, S; Shibata, H; Ushijima, F; Hashimoto, T; Nakashima, K; Ito, K; Yamamoto, T; Numaguchi, A; Inden, Y; Ishii, M

    INTERNATIONAL CANCER CONFERENCE JOURNAL   Vol. 12 ( 4 ) page: 299 - 304   2023.10

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  13. Subclinical persistent atrial fibrillation in left atrium behind the ectopic atrial rhythm on electrocardiogram.

    Mizutani Y, Yanagisawa S, Makino Y, Kanashiro M, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 9 ( 9 ) page: 685 - 688   2023.9

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    Language:English  

    DOI: 10.1016/j.hrcr.2023.07.005

    PubMed

  14. Different time course effect of autonomic nervous modulation after cryoballoon and hotballoon catheter ablations for paroxysmal atrial fibrillation

    Suzuki, N; Inden, Y; Yanagisawa, S; Shimizu, Y; Narita, S; Hiramatsu, K; Yamauchi, R; Watanabe, R; Tsurumi, N; Shimojo, M; Suga, K; Tsuji, Y; Shibata, R; Murohara, T

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY     2023.6

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  15. Evaluation of the direction and extent of ice formation during cryoballoon ablation: an experimental study

    Mizutani, Y; Yanagisawa, S; Fujiwara, G; Kasai, Y; Tajima, A; Makino, Y; Suzuki, H; Hiramatsu, T; Ichimiya, H; Uchida, Y; Watanabe, J; Kanashiro, M; Inden, Y; Murohara, T

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 66 ( 4 ) page: 981 - 989   2023.6

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  16. Successful catheter ablation for a dominant atrial fibrillation driver manifested after box isolation using a novel mapping system in a patient with persistent atrial fibrillation.

    Tachi M, Teraoka T, Hayashi K, Yanagisawa S, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 9 ( 5 ) page: 319 - 323   2023.5

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    DOI: 10.1016/j.hrcr.2023.02.010

    PubMed

  17. Transmural lesion formation after left atrial roof cryoballoon ablation: Insight from simultaneous high-density epicardial mapping

    Kato, H; Yanagisawa, S; Sakurai, T; Murakami, H; Inden, Y; Murohara, T

    HEART RHYTHM O2   Vol. 4 ( 5 ) page: 329 - 332   2023.5

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  18. Catheter ablation for atrial fibrillation in heart failure: Getting closer to the full picture in the whole population

    Yanagisawa, S; Inden, Y; Murohara, T

    INTERNATIONAL JOURNAL OF CARDIOLOGY   Vol. 376   page: 81 - 82   2023.4

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  19. The ridge line of left pulmonary vein isolation from left atrial appendage can subsequently increase the completion rate of the mitral isthmus block line

    Hori, H; Kaneko, S; Fujita, M; Nagai, S; Ito, R; Shirai, Y; Adachi, K; Suzuki, N; Suzuki, J; Kondo, K; Yamauchi, R; Haga, T; Tatami, Y; Ohashi, T; Kubota, R; Shinoda, M; Tanaka, A; Inden, Y; Murohara, T

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 66 ( 3 ) page: 673 - 681   2023.4

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  20. A rare case of delayed complete lead dislodgement after deep septal pacing: A hidden risk of the specific procedure

    Watanabe, R; Inden, Y; Yanagisawa, S; Narita, Y; Hiramatsu, K; Yamauchi, R; Tsurumi, N; Suzuki, N; Shimojo, M; Suga, K; Tsuji, Y; Murohara, T

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   Vol. 46 ( 4 ) page: 341 - 345   2023.4

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  21. A novel practical algorithm using machine learning to differentiate outflow tract ventricular arrhythmia origins

    Shimojo, M; Inden, Y; Yanagisawa, S; Suzuki, N; Tsurumi, N; Watanabe, R; Nakagomi, T; Okajima, T; Suga, K; Tsuji, Y; Murohara, T

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 34 ( 3 ) page: 627 - 637   2023.3

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  22. HotBalloon Pulmonary Vein Isolation Registry Study - Real-World Efficacy and Safety of HotBalloon Ablation -

    Yamasaki, H; Nakahara, S; Sohara, H; Yoshida, Y; Kohno, T; Shimane, A; Miyauchi, Y; Kusano, K; Inden, Y; Yamane, T; Aonuma, K

    CIRCULATION JOURNAL   Vol. 87 ( 1 ) page: 65 - +   2023.1

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  23. Stereotactic radiotherapy for ventricular tachycardia: A study protocol.

    Kawamura M, Shimojo M, Inden Y, Kamomae T, Okudaira K, Komada T, Aoki S, Shindo Y, Yasui R, Yanagi Y, Okumura M, Yamada T, Kozai Y, Oie Y, Kato Y, Ishihara S, Murohara T, Naganawa S

    F1000Research   Vol. 12   page: 798   2023

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    Language:English  

    DOI: 10.12688/f1000research.138758.2

    PubMed

  24. Higher F-wave frequency associates with poor procedural success rate after Maze procedure

    Usui, R; Mutsuga, M; Narita, Y; Tokuda, Y; Terazawa, S; Ito, H; Uchida, W; Inden, Y; Murohara, T; Usui, A

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 70 ( 12 ) page: 997 - 1004   2022.12

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  25. Efficacy and feasibility of cryoballoon ablation for atrial fibrillation in patients with heart failure: A large-scale multicenter study

    Yanagisawa, S; Suzuki, H; Kanzaki, Y; Ishikawa, S; Kamikubo, Y; Okumura, S; Kato, H; Mizutani, Y; Murase, Y; Nakasuka, K; Warita, S; Sekimoto, S; Takemoto, Y; Takasugi, N; Ohguchi, S; Senga, M; Yokoi, K; Shibata, R; Inden, Y; Murohara, T

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 33 ( 12 ) page: 2447 - 2464   2022.12

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  26. A case of successful catheter ablation of blocked atrial bigeminy and bradycardia with the recovery of normal sinus rhythm and myocardial reverse remodeling

    Sugiyama, T; Mizutani, Y; Yanagisawa, S; Kanashiro, M; Inden, Y; Murohara, T

    CLINICAL CASE REPORTS   Vol. 10 ( 12 ) page: e6791   2022.12

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  27. JCS/JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias

    Ono, K; Iwasaki, YK; Akao, M; Ikeda, T; Ishii, K; Inden, Y; Kusano, K; Kobayashi, Y; Koretsune, Y; Sasano, T; Sumitomo, N; Takahashi, N; Niwano, S; Hagiwara, N; Hisatome, I; Furukawa, T; Honjo, H; Maruyama, T; Murakawa, Y; Yasaka, M; Watanabe, E; Aiba, T; Amino, M; Itoh, H; Ogawa, H; Okumura, Y; Aoki-Kamiya, C; Kishihara, J; Kodani, E; Komatsu, T; Sakamoto, Y; Satomi, K; Shiga, T; Shinohara, T; Suzuki, A; Suzuki, S; Sekiguchi, Y; Nagase, S; Hayami, N; Harada, M; Fujino, T; Makiyama, T; Maruyama, M; Miake, J; Muraji, S; Murata, H; Morita, N; Yokoshiki, H; Yoshioka, K; Yodogawa, K; Inoue, H; Okumura, K; Kimura, T; Tsutsui, H; Shimizu, W

    JOURNAL OF ARRHYTHMIA   Vol. 38 ( 6 ) page: 833 - 973   2022.12

  28. Regional left atrial conduction velocity in the anterior wall is associated with clinical recurrence of atrial fibrillation after catheter ablation: efficacy in combination with the ipsilateral low voltage area

    Ohguchi, S; Inden, Y; Yanagisawa, S; Fujita, R; Yasuda, K; Katagiri, K; Oguri, M; Murohara, T

    BMC CARDIOVASCULAR DISORDERS   Vol. 22 ( 1 ) page: 457   2022.11

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  29. JCS/JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias Reviewed

    Ono, K; Iwasaki, YK; Akao, M; Ikeda, T; Ishii, K; Inden, Y; Kusano, K; Kobayashi, Y; Koretsune, Y; Sasano, T; Sumitomo, N; Takahashi, N; Niwano, S; Hagiwara, N; Hisatome, I; Furukawa, T; Honjo, H; Maruyama, T; Murakawa, Y; Yasaka, M; Watanabe, E; Aiba, T; Amino, M; Itoh, H; Ogawa, H; Okumura, Y; Aoki-Kamiya, C; Kishihara, J; Kodani, E; Komatsu, T; Sakamoto, Y; Satomi, K; Shiga, T; Shinohara, T; Suzuki, A; Suzuki, S; Sekiguchi, Y; Nagase, S; Hayami, N; Harada, M; Fujino, T; Makiyama, T; Maruyama, M; Miake, J; Muraji, S; Murata, H; Morita, N; Yokoshiki, H; Yoshioka, K; Yodogawa, K; Inoue, H; Okumura, K; Kimura, T; Tsutsui, H; Shimizu, W

    CIRCULATION JOURNAL   Vol. 86 ( 11 ) page: 1790 - 1924   2022.11

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  30. Septal coronary artery fistula after left bundle branch area pacing assessed by multi-imaging modalities and shunt volume quantification

    Kato, H; Yanagisawa, S; Ota, R; Murakami, H; Kada, K; Tsuboi, N; Inden, Y; Murohara, T

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   Vol. 45 ( 11 ) page: 1299 - 1302   2022.11

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  31. Impact of synchronized left ventricular pacing rate on risk for ventricular tachyarrhythmias after cardiac resynchronization therapy in patients with heart failure

    Okajima, T; Inden, Y; Yanagisawa, S; Suga, K; Shimojo, M; Nakagomi, T; Tsurumi, N; Watanabe, R; Suzuki, N; Shibata, R; Murohara, T

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 65 ( 1 ) page: 239 - 249   2022.10

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  32. Depolarization and repolarization dynamics after His-bundle pacing: Comparison with right ventricular pacing and native ventricular conduction

    Yanagisawa, S; Inden, Y; Watanabe, R; Tsurumi, N; Suzuki, N; Nakagomi, T; Shimojo, M; Okajima, T; Riku, S; Furui, K; Suga, K; Shibata, R; Murohara, T

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   Vol. 27 ( 5 ) page: e12991   2022.9

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  33. Characteristics of successful reactive atrial-based antitachycardia pacing in patients with cardiac implantable electronic devices: History of catheter ablation of atrial fibrillation as a predictor of high treatment efficacy

    Nakagomi, T; Inden, Y; Yanagisawa, S; Suzuki, N; Tsurumi, N; Watanabe, R; Shimojo, M; Okajima, T; Suga, K; Shibata, R; Murohara, T

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 33 ( 7 ) page: 1515 - 1528   2022.7

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  34. Short coupling interval with high burden of atrial ectopy predicts recurrence after atrial fibrillation ablation Reviewed

    Okajima, T; Inden, Y; Yanagisawa, S; Imai, H; Murase, Y; Ogawa, Y; Kawaguchi, K; Murohara, T

    HEART AND VESSELS   Vol. 37 ( 5 ) page: 775 - 787   2022.5

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  35. Cryoballoon ablation for atrial fibrillation without the use of a contrast medium: a combination of the intracardiac echocardiography and pressure wave monitoring guided approach Reviewed

    Makino, Y; Mizutani, Y; Yamashita, D; Yonekawa, J; Satake, A; Kurobe, M; Hiramatsu, T; Ichimiya, H; Uchida, Y; Watanabe, J; Kanashiro, M; Ichimiya, S; Yanagisawa, S; Inden, Y; Murohara, T

    HEART AND VESSELS   Vol. 37 ( 5 ) page: 765 - 774   2022.5

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  36. Identification of high priority focal activations in persistent atrial fibrillation using a novel mapping strategy Reviewed

    Shimojo, M; Inden, Y; Yanagisawa, S; Riku, S; Suga, K; Furui, K; Nakagomi, T; Okajima, T; Shibata, R; Murohara, T

    HEART AND VESSELS   Vol. 37 ( 5 ) page: 840 - 853   2022.5

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  37. Evaluation of the Novel Automated Anti-Tachycardia Pacing Algorithm Successfully Terminating Sustained Monomorphic Ventricular Tachycardia in an Electrophysiology Study A Case Report

    Yanagisawa, S; Inden, Y; Okajima, T; Nakagomi, T; Shimojo, M; Watanabe, R; Tsurumi, N; Suzuki, N; Suga, K; Shibata, R; Murohara, T

    INTERNATIONAL HEART JOURNAL   Vol. 63 ( 3 ) page: 633 - 638   2022.5

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  38. Very long-term clinical outcomes after percutaneous coronary intervention for complex vs non-complex lesions: 10-year outcomes following sirolimus-eluting stent implantation

    Riku, S; Suzuki, S; Yokoi, T; Sakaguchi, T; Yamamoto, T; Jinno, Y; Tanaka, A; Ishii, H; Inden, Y; Murohara, T

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 2 ) page: 352 - 365   2022.5

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  39. Long P-wave duration immediately after pulmonary vein isolation on radiofrequency catheter ablation for atrial fibrillation predicts clinical recurrence: correlation with atrial remodeling in persistent atrial fibrillation Reviewed

    Ohguchi, S; Inden, Y; Yanagisawa, S; Shigematsu, T; Yasuda, K; Katagiri, K; Oguri, M; Murohara, T

    HEART AND VESSELS   Vol. 37 ( 3 ) page: 476 - 488   2022.3

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  40. Impact of Preoperative Nutritional Status on the Outcome of Catheter Ablation for Atrial Fibrillation Reviewed

    Furui, K; Morishima, I; Morita, Y; Kanzaki, Y; Takagi, K; Nagai, H; Watanabe, N; Yoshioka, N; Yamauchi, R; Miyazawa, H; Yanagisawa, S; Inden, Y; Murohara, T

    CIRCULATION JOURNAL   Vol. 86 ( 2 ) page: 268 - +   2022.2

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  41. Comparison of the empirical linear ablation and low voltage area-guided ablation in addition to pulmonary vein isolation in patients with persistent atrial fibrillation: a propensity score-matched analysis Reviewed

    Suzuki, N; Kaneko, S; Fujita, M; Shinoda, M; Kubota, R; Ohashi, T; Tatami, Y; Suzuki, J; Hori, H; Adachi, K; Ito, R; Shirai, Y; Yanagisawa, S; Inden, Y; Murohara, T

    BMC CARDIOVASCULAR DISORDERS   Vol. 22 ( 1 ) page: 13   2022.1

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  42. Efficacy of His Bundle Pacing on LV Relaxation and Clinical Improvement in HF and LBBB Reviewed

    Kato, H; Yanagisawa, S; Sakurai, T; Mizuno, C; Ota, R; Watanabe, R; Suga, K; Okada, T; Murakami, H; Kada, K; Inden, Y; Tsuboi, N; Murohara, T

    JACC-CLINICAL ELECTROPHYSIOLOGY   Vol. 8 ( 1 ) page: 59 - 69   2022.1

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  43. Usefulness of the Snare Technique During Leadless Pacemaker Implantation for a Patient with a Severely Dilated Right Atrium A Case Report Reviewed

    Hiramatsu, T; Mizutani, Y; Yanagisawa, S; Sugiyama, T; Yamashita, D; Tajima, A; Yonekawa, J; Makino, Y; Suzuki, H; Ichimiya, H; Uchida, Y; Watanabe, J; Kanashiro, M; Inden, Y; Murohara, T

    INTERNATIONAL HEART JOURNAL   Vol. 63 ( 1 ) page: 159 - 162   2022.1

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  44. Permanent His-bundle pacing using distal His-bundle electrogram-guided approach in patients with atrioventricular block Reviewed

    Suga, K; Kato, H; Inden, Y; Yanagisawa, S; Murakami, H; Kada, K; Tsuboi, N; Murohara, T

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   Vol. 44 ( 11 ) page: 1907 - 1917   2021.11

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  45. Earliest pulmonary vein potential-guided cryoballoon ablation is associated with better clinical outcomes than conventional cryoballoon ablation: A result from two randomized clinical studies Reviewed

    Mizutani, Y; Yanagisawa, S; Kanashiro, M; Yamashita, D; Yonekawa, J; Makino, Y; Hiramatsu, T; Ichimiya, H; Uchida, Y; Watanabe, J; Ichimiya, S; Inden, Y; Murohara, T

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 32 ( 11 ) page: 2933 - 2942   2021.11

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  46. Incidence of Left Atrial Thrombus Development and Imaging Approach in Patients Scheduled for Repeat Catheter Ablation for Atrial Fibrillation Reviewed

    Yanagisawa, S; Inden, Y; Riku, S; Suga, K; Furui, K; Nakagomi, T; Shimojo, M; Okajima, T; Shibata, R; Murohara, T

    AMERICAN JOURNAL OF CARDIOLOGY   Vol. 155   page: 52 - 63   2021.9

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  47. Dynamic Changes in Electrocardiogram Parameters After Epicardial Substrate Catheter Ablation of Brugada Syndrome. Reviewed

    Mamiya K, Inden Y, Yanagisawa S, Fujii A, Tomomatsu T, Okamoto H, Riku S, Suga K, Furui K, Nakagomi T, Shibata R, Murohara T

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 85 ( 8 ) page: 1283 - +   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-20-1060

    Web of Science

    PubMed

  48. Disappearance pattern and the last remaining earliest pulmonary vein potential during cryoballoon ablation in predicting recurrence and conduction gap site of pulmonary veins Reviewed

    Mizutani Yoshiaki, Inden Yasuya, Yanagisawa Satoshi, Kanashiro Masaaki, Makino Yuichiro, Satake Akinori, Kurobe Masanari, Ichimiya Hitoshi, Uchida Yasuhiro, Watanabe Junji, Ichimiya Satoshi, Murohara Toyoaki

    HEART AND VESSELS   Vol. 36 ( 8 ) page: 1190 - 1200   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00380-021-01785-3

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    PubMed

  49. JCS/JHRS 2019 guideline on non-pharmacotherapy of cardiac arrhythmias

    Nogami, A; Kurita, T; Abe, H; Ando, K; Ishikawa, T; Imai, K; Usui, A; Okishige, K; Kusano, K; Kumagai, K; Goya, M; Kobayashi, Y; Shimizu, A; Shimizu, W; Shoda, M; Sumitomo, N; Seo, Y; Takahashi, A; Tada, H; Naito, S; Nakazato, Y; Nishimura, T; Nitta, T; Niwano, S; Hagiwara, N; Murakawa, Y; Yamane, T; Aiba, T; Inoue, K; Iwasaki, Y; Inden, Y; Uno, K; Ogano, M; Kimura, M; Sakamoto, S; Sasaki, S; Satomi, K; Shiga, T; Suzuki, T; Sekiguchi, Y; Soejima, K; Takagi, M; Chinushi, M; Nishi, N; Noda, T; Hachiya, H; Mitsuno, M; Mitsuhashi, T; Miyauchi, Y; Miyazaki, A; Morimoto, T; Yamasaki, H; Aizawa, Y; Ohe, T; Kimura, T; Tanemoto, K; Tsutsui, H; Mitamura, H

    JOURNAL OF ARRHYTHMIA   Vol. 37 ( 4 ) page: 709 - 870   2021.8

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  50. Defibrillation threshold of internal cardioversion prior to ablation predicts atrial fibrillation recurrence Reviewed

    Sawasaki, K; Inden, Y; Hosoya, N; Muto, M; Murohara, T

    CLINICAL CARDIOLOGY   Vol. 44 ( 8 ) page: 1169 - 1176   2021.8

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  51. JCS/JHRS 2019 Guideline on Non-Pharmacotherapy of Cardiac Arrhythmias. Reviewed

    Nogami A, Kurita T, Abe H, Ando K, Ishikawa T, Imai K, Usui A, Okishige K, Kusano K, Kumagai K, Goya M, Kobayashi Y, Shimizu A, Shimizu W, Shoda M, Sumitomo N, Seo Y, Takahashi A, Tada H, Naito S, Nakazato Y, Nishimura T, Nitta T, Niwano S, Hagiwara N, Murakawa Y, Yamane T, Aiba T, Inoue K, Iwasaki Y, Inden Y, Uno K, Ogano M, Kimura M, Sakamoto SI, Sasaki S, Satomi K, Shiga T, Suzuki T, Sekiguchi Y, Soejima K, Takagi M, Chinushi M, Nishi N, Noda T, Hachiya H, Mitsuno M, Mitsuhashi T, Miyauchi Y, Miyazaki A, Morimoto T, Yamasaki H, Aizawa Y, Ohe T, Kimura T, Tanemoto K, Tsutsui H, Mitamura H, JCS/JHRS Joint Working Group.

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 85 ( 7 ) page: 1104 - 1244   2021.7

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    DOI: 10.1253/circj.CJ-20-0637

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  52. The mechanism and prognosis of acute and late improvement in mitral regurgitation after cardiac resynchronization therapy Reviewed

    Okamoto Hiroya, Inden Yasuya, Yanagisawa Satoshi, Fujii Aya, Tomomatsu Toshiro, Mamiya Keita, Riku Shuro, Suga Kazumasa, Furui Koichi, Nakagomi Toshifumi, Shibata Rei, Murohara Toyoaki

    HEART AND VESSELS   Vol. 36 ( 7 ) page: 986 - 998   2021.7

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    DOI: 10.1007/s00380-021-01771-9

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  53. Defibrillation threshold of internal cardioversion prior to ablation predicts atrial fibrillation recurrence Reviewed

    Sawasaki K, Inden Y, Hosoya N, Muto M, Murohara T

    Clin Cardiol     2021.6

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  54. Coagulation Response and Prothrombotic Effect of Uninterrupted Oral Anticoagulant Administration After Catheter Ablation for VT

    Yanagisawa, S; Inden, Y; Riku, S; Furui, K; Suga, K; Nakagomi, T; Shimojo, M; Okajima, T; Watanabe, R; Tsurumi, N; Suzuki, N; Shibata, R; Murohara, T

    JACC-CLINICAL ELECTROPHYSIOLOGY   Vol. 8 ( 6 ) page: 735 - 748   2021.6

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  55. A case of heart failure complicated with double ventricular response triggered by beta blocker. Reviewed

    Kazama S, Kondo T, Suga K, Yanagisawa S, Morimoto R, Okumura T, Inden Y, Murohara T

    HeartRhythm case reports   Vol. 7 ( 3 ) page: 174 - 177   2021.3

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    DOI: 10.1016/j.hrcr.2020.12.004

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  56. Early improvement of daily physical activity after catheter ablation for atrial fibrillation in an accelerometer assessment: A prospective pilot study Reviewed

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Sakamoto Yusuke, Tomomatsu Toshiro, Mamiya Keita, Okamoto Hiroya, Murohara Toyoaki, Shibata Rei

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   Vol. 26 ( 1 ) page: e12807   2021.1

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    DOI: 10.1111/anec.12807

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  57. CORRIGENDUM: JCS/JHRS 2019 Guideline on Non-Pharmacotherapy of Cardiac Arrhythmias.

    Nogami A, Kurita T, Abe H, Ando K, Ishikawa T, Imai K, Usui A, Okishige K, Kusano K, Kumagai K, Goya M, Kobayashi Y, Shimizu A, Shimizu W, Shoda M, Sumitomo N, Seo Y, Takahashi A, Tada H, Naito S, Nakazato Y, Nishimura T, Nitta T, Niwano S, Hagiwara N, Murakawa Y, Yamane T, Aiba T, Inoue K, Iwasaki Y, Inden Y, Uno K, Ogano M, Kimura M, Sakamoto SI, Sasaki S, Satomi K, Shiga T, Suzuki T, Sekiguchi Y, Soejima K, Takagi M, Chinushi M, Nishi N, Noda T, Hachiya H, Mitsuno M, Mitsuhashi T, Miyauchi Y, Miyazaki A, Morimoto T, Yamasaki H, Aizawa Y, Ohe T, Kimura T, Tanemoto K, Tsutsui H, Mitamura H, JCS/JHRS Joint Working Group.

    Circulation journal : official journal of the Japanese Circulation Society   Vol. 85 ( 9 ) page: 1692 - 1700   2021

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    DOI: 10.1253/circj.CJ-66-0196

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  58. Improved Risk Stratification of Patients With Brugada Syndrome by the New Japanese Circulation Society Guideline - A Multicenter Validation Study - Reviewed

    Wakamiya Akinori, Kamakura Tsukasa, Shinohara Tetsuji, Yodogawa Kenji, Murakoshi Nobuyuki, Morita Hiroshi, Takahashi Naohiko, Inden Yasuya, Shimizu Wataru, Nogami Akihiko, Horie Minoru, Nakajima Kenzaburo, Kataoka Naoya, Wada Mitsuru, Yamagata Kenichiro, Ishibashi Kohei, Inoue Yuko, Miyamoto Koji, Nagase Satoshi, Noda Takashi, Aiba Takeshi, Yasuda Satoshi, Ieda Masaki, Kusano Kengo

    CIRCULATION JOURNAL   Vol. 84 ( 12 ) page: 2158 - +   2020.12

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  59. Safety and efficacy of first-line cryoablation for para-hisian ventricular arrhythmias using a cryomapping protocol approach: A case series Reviewed

    Mizutani Yoshiaki, Yanagisawa Satoshi, Kanashiro Masaaki, Inden Yasuya, Murohara Toyoaki

    CLINICAL CASE REPORTS   Vol. 8 ( 12 ) page: 3247 - 3252   2020.12

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    DOI: 10.1002/ccr3.3401

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  60. Autopsy evaluation of the implantation site of a His bundle pacing lead demonstrating selective capture Reviewed

    Kato Hiroyuki, Igawa Osamu, Suga Kazumasa, Murakami Hisashi, Kada Kenji, Tsuboi Naoya, Yanagisawa Satoshi, Inden Yasuya, Murohara Toyoaki

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   Vol. 43 ( 11 ) page: 1412 - 1416   2020.11

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    DOI: 10.1111/pace.13989

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  61. The impact of the dominant frequency of body surface electrocardiography in patients with persistent atrial fibrillation Reviewed International coauthorship

    Murase Yosuke, Inden Yasuya, Shibata Rei, Yanagisawa Satoshi, Fujii Aya, Ando Monami, Otake Noriaki, Takenaka Masaki, Funabiki Junya, Sakamoto Yusuke, Murohara Toyoaki

    HEART AND VESSELS   Vol. 35 ( 7 ) page: 967 - 976   2020.7

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    DOI: 10.1007/s00380-020-01563-7

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  62. Periprocedural Management of Cardiac Tamponade During Catheter Ablation for AF Under Uninterrupted DOAC and Warfarin Reviewed

    Yanagisawa Satoshi, Inden Yasuya, Ohguchi Shiou, Nagao Tomoyuki, Fujii Aya, Tomomatsu Toshiro, Mamiya Keita, Okamoto Hiroya, Sakamoto Yusuke, Shibata Rei, Murohara Toyoaki

    JACC-CLINICAL ELECTROPHYSIOLOGY   Vol. 6 ( 7 ) page: 786 - 795   2020.7

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  63. Prospective comparison of periprocedural coagulation markers among uninterrupted anticoagulants for atrial fibrillation ablation Reviewed

    Nagao Tomoyuki, Higo Sayaka, Suzuki Hitomi, Teshima Yuto, Matsunaga Syun, Harada Kazuhiro, Shinoda Norihiro, Harada Ken, Kato Masataka, Marui Nobuyuki, Amano Tetsuya, Inden Yasuya, Murohara Toyoaki

    HEART RHYTHM   Vol. 17 ( 3 ) page: 391 - 397   2020.3

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    DOI: 10.1016/j.hrthm.2019.10.015

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  64. Electrocardiogram characteristics of P wave associated with successful pulmonary vein isolation in patients with paroxysmal atrial fibrillation: Significance of changes in P-wave duration and notched P wave Reviewed

    Yanagisawa Satoshi, Inden Yasuya, Okamoto Hiroya, Fujii Aya, Sakamoto Yusuke, Mamiya Keita, Tomomatsu Toshiro, Shibata Rei, Murohara Toyoaki

    ANNALS OF NONINVASIVE ELECTROCARDIOLOGY   Vol. 25 ( 2 ) page: e12712   2020.3

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    DOI: 10.1111/anec.12712

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  65. Earliest pulmonary vein potential-guided cryoballoon ablation for atrial fibrillation Reviewed

    Mizutani Yoshiaki, Kanashiro Masaaki, Makino Yuichiro, Satake Akinori, Suzuki Wataru, Kurobe Masanari, Mizutani Kouji, Ichimiya Hitoshi, Uchida Yasuhiro, Watanabe Junji, Ichimiya Satoshi, Inden Yasuya, Murohara Toyoaki

    HEART AND VESSELS   Vol. 35 ( 2 ) page: 232 - 238   2020.2

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    DOI: 10.1007/s00380-019-01471-5

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  66. Long-term prognosis of patients with J-wave syndrome Reviewed

    Kamakura Tsukasa, Shinohara Tetsuji, Yodogawa Kenji, Murakoshi Nobuyuki, Morita Hiroshi, Takahashi Naohiko, Inden Yasuya, Shimizu Wataru, Nogami Akihiko, Horie Minoru, Aiba Takeshi, Kusano Kengo

    HEART   Vol. 106 ( 4 ) page: 299 - 306   2020.2

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    DOI: 10.1136/heartjnl-2019-315007

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  67. Anatomical assessment of crosstalk phenomenon during laser balloon ablation with imaging in a patient with unusual atrial hypertrophy Reviewed

    Yanagisawa Satoshi, Inden Yasuya, Okamoto Hiroya, Tomomatsu Toshiro, Fujii Aya, Mamiya Keita, Shibata Rei, Murohara Toyoaki

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 57 ( 1 ) page: 157 - 159   2020.1

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    DOI: 10.1007/s10840-019-00632-w

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  68. Hot-Balloon Pulmonary Vein Isolation Registry Study (HARVEST Study): The Efficacy and Safety Data of SATAKE Hot-Balloon in the Real World Reviewed

    Nakahara Shiro, Sohara Hiroshi, Nakamura Yoshinori, Yamasaki Hiro, Yoshida Yukihiko, Kohno Tsunesuke, Shimane Akira, Miyauchi Yasushi, Okano Yoshifumi, Shioji Keisuke, Fukae Satoki, Satake Shutaro, Ozawa Tomoya, Kobori Atsushi, Kamijima Toru, Muto Masahiro, Nagashima Koichi, Naito Shigeto, Usui Tatsuya, Harada Masahide, Sasaki Takeshi, Watanabe Tetsuya, Fukata Mitsuhiro, Yamane Teiichi, Oba Kageyuki, Kimura Masaomi, Murakami Hisashi, Sugiura Hirotaka, Kusano Kengo, Inden Yasuya, Aonuma Kazutaka

    CIRCULATION   Vol. 140 ( 25 ) page: E990 - E991   2019.12

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  69. Prothrombotic Responses After Catheter Ablation for Atrial Fibrillation During Uninterrupted Oral Anticoagulant Agent Administration Reviewed

    JACC-CLINICAL ELECTROPHYSIOLOGY   Vol. 5 ( 12 ) page: 1418 - 1427   2019.12

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    DOI: 10.1016/j.jacep.2019.09.002

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  70. Study design and protocol for evaluating the long-term prognosis of patients receiving his bundle pacing: A multicenter observational study Reviewed

    Yanagisawa Satoshi, Inden Yasuya, Kato Hiroyuki, Suzuki Hirohiko, Fujita Masaya, Ishikawa Shinji, Kanzaki Yasunori, Kamikubo Yosuke, Murase Yosuke, Murohara Toyoaki, Shibata Rei

    JOURNAL OF ARRHYTHMIA   Vol. 35 ( 5 ) page: 760 - 765   2019.10

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    DOI: 10.1002/joa3.12229

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  71. T-wave changes of cardiac memory caused by frequent premature ventricular contractions originating from the right ventricular outflow tract Reviewed

    Sakamoto Yusuke, Inden Yasuya, Okamoto Hiroya, Mamiya Keita, Tomomatsu Toshiro, Fujii Aya, Yanagisawa Satoshi, Shibata Rei, Hirai Makoto, Murohara Toyoaki

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 30 ( 9 ) page: 1549 - 1556   2019.9

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    DOI: 10.1111/jce.14008

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  72. Discontinuous contraction in the left ventricle assessed by 2-D speckle tracking echocardiography benefits from CRT Reviewed

    Fujii Aya, Inden Yasuya, Yanagisawa Satoshi, Mamiya Keita, Okamoto Hiroya, Sakamoto Yusuke, Tomomatsu Toshiro, Shibata Rei, Murohara Toyoaki

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   Vol. 42 ( 9 ) page: 1204 - 1212   2019.9

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    DOI: 10.1111/pace.13759

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  73. Differences in prothrombotic response between the uninterrupted and interrupted apixaban therapies in patients undergoing cryoballoon ablation for paroxysmal atrial fibrillation: a randomized controlled study (vol 34, pg 1533, 2019)

    Ando, M; Inden, Y; Yoshida, Y; Sairaku, A; Yanagisawa, S; Suzuki, H; Watanabe, R; Takenaka, M; Maeda, M; Murohara, T

    HEART AND VESSELS   Vol. 34 ( 9 ) page: 1542 - 1542   2019.9

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  74. Differences in prothrombotic response between the uninterrupted and interrupted apixaban therapies in patients undergoing cryoballoon ablation for paroxysmal atrial fibrillation: a randomized controlled study

    Ando, M; Inden, Y; Yoshida, Y; Sairaku, A; Yanagisawa, S; Suzuki, H; Watanabe, R; Takenaka, M; Maeda, M; Murohara, T

    HEART AND VESSELS   Vol. 34 ( 9 ) page: 1533 - 1541   2019.9

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  75. Identification of precise accessory pathway using ultra-high-resolution three-dimensional mapping system: utility and feasibility in preliminary experience

    Yanagisawa, S; Inden, Y; Fujii, A; Sakamoto, Y; Ichiyanagi, H; Shibata, R; Murohara, T

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 55 ( 2 ) page: 241 - 242   2019.8

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  76. His bundle pacing with unusual automaticity

    Yanagisawa, S; Inden, Y; Shibata, R; Murohara, T

    JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   Vol. 30 ( 6 ) page: 966 - 968   2019.6

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  77. Clinical significance of the timing of early recurrence of atrial arrhythmia after pulmonary vein isolation: a two-institution clinical study.

    Murase Y, Inden Y, Imai H, Kyo S, Yanagisawa S, Fujii A, Sakamoto Y, Tomomatsu T, Murohara T

    Heart and vessels   Vol. 34 ( 5 ) page: 842 - 850   2019.5

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    DOI: 10.1007/s00380-018-1295-1

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  78. Adjacentmultiple accessory pathways demonstrated on ultra-high-resolution mapping

    Yanagisawa, S; Inden, Y; Murohara, T

    EUROPACE   Vol. 21 ( 5 ) page: 723 - 723   2019.5

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  79. Impact of periprocedural anticoagulation therapy on the incidence of silent stroke after atrial fibrillation ablation in patients receiving direct oral anticoagulants: uninterrupted vs. interrupted by one dose strategy.

    Nagao T, Suzuki H, Matsunaga S, Nishikawa Y, Harada K, Mamiya K, Shinoda N, Harada K, Kato M, Marui N, Amano T, Inden Y, Murohara T

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology   Vol. 21 ( 4 ) page: 590 - 597   2019.4

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    DOI: 10.1093/europace/euy224

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  80. Myocardial viability as shown by left ventricular lead pacing threshold and improved dyssynchrony by QRS narrowing predicts the response to cardiac resynchronization therapy.

    Takenaka M, Inden Y, Yanagisawa S, Fujii A, Ando M, Funabiki J, Murase Y, Otake N, Sakamoto Y, Shibata R, Murohara T

    Journal of cardiovascular electrophysiology   Vol. 30 ( 3 ) page: 311 - 319   2019.3

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    DOI: 10.1111/jce.13806

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  81. Atypical Fast-Slow Atrioventricular Nodal Reentrant Tachycardia Utilizing a Slow Pathway Extending to the Inferolateral Right Atrium.

    Kaneko Y, Nakajima T, Nogami A, Inden Y, Asakawa T, Morishima I, Mizukami A, Iizuka T, Tamura S, Ota C, Kanzaki Y, Nakagawa K, Suzuki M, Kurabayashi M

    Circulation reports   Vol. 1 ( 2 ) page: 46 - 54   2019.1

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    DOI: 10.1253/circrep.CR-18-0016

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  82. Uninterrupted Direct Oral Anticoagulant and Warfarin Administration in Elderly Patients Undergoing Catheter Ablation for Atrial Fibrillation: A Comparison With Younger Patients.

    Yanagisawa S, Inden Y, Fujii A, Ando M, Funabiki J, Murase Y, Takenaka M, Otake N, Ikai Y, Sakamoto Y, Shibata R, Murohara T

    JACC. Clinical electrophysiology   Vol. 4 ( 5 ) page: 592 - 600   2018.5

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    DOI: 10.1016/j.jacep.2018.02.013

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  83. Comparison of uninterrupted anticoagulation with dabigatran etexilate or warfarin in the periprocedural period for atrial fibrillation catheter ablation: Results of the Japanese subgroup of the RE-CIRCUIT trial

    Yoshida Yukihiko, Watarai Masato, Fujii Kenshi, Shimizu Wataru, Satomi Kazuhiro, Inden Yasuya, Murakami Yoshimasa, Murakami Masato, Iwasa Atsushi, Kimura Masaomi, Yamada Nobuko, Nakagawa Tomofumi, Nordaby Matias, Okumura Ken

    JOURNAL OF ARRHYTHMIA   Vol. 34 ( 2 ) page: 148 - 157   2018.4

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    DOI: 10.1002/joa3.12024

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  84. Head-to-head comparison of acute and chronic pulmonary vein stenosis for cryoballoon versus radiofrequency ablation

    Watanabe Ryo, Sairaku Akinori, Yoshida Yukihiko, Nanasato Mamoru, Kamiya Hiroki, Suzuki Hirohiko, Ogura Yasuhiro, Aoyama Yutaka, Maeda Mayuho, Ando Monami, Eguchi Shunsuke, Inden Yasuya, Kihara Yasuki, Murohara Toyoaki

    PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   Vol. 41 ( 4 ) page: 376 - 382   2018.4

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    DOI: 10.1111/pace.13293

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  85. Renal function and risk of stroke and bleeding in patients undergoing catheter ablation for atrial fibrillation: Comparison between uninterrupted direct oral anticoagulants and warfarin administration

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Ikai Yoshihiro, Sakamoto Yusuke, Shibata Rei, Murohara Toyoaki

    HEART RHYTHM   Vol. 15 ( 3 ) page: 348 - 354   2018.3

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    DOI: 10.1016/j.hrthm.2017.10.033

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  86. Assessment of autonomic nervous system modulation after novel catheter ablation techniques for atrial fibrillation using multiple short-term electrocardiogram recordings

    Yanagisawa Satoshi, Inden Yasuya, Fujii Aya, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Ikai Yoshihiro, Sakamoto Yusuke, Shibata Rei, Murohara Toyoaki

    JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY   Vol. 51 ( 1 ) page: 35 - 44   2018.1

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    DOI: 10.1007/s10840-017-0295-x

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  87. Monitoring of anti-Xa activity and factors related to bleeding events: A study in Japanese patients with nonvalvular atrial fibrillation receiving rivaroxaban

    Sakaguchi Teruhiro, Osanai Hiroyuki, Murase Yosuke, Ishii Hideki, Nakashima Yoshihito, Asano Hiroshi, Suzuki Susumu, Takefuji Mikito, Inden Yasuya, Sakai Kazuyoshi, Murohara Toyoaki, Ajioka Masayoshi

    JOURNAL OF CARDIOLOGY   Vol. 70 ( 3-4 ) page: 244 - 249   2017.9

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    DOI: 10.1016/j.jjcc.2016.11.013

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  88. Different rate-dependent responses between J waves and the notches on an epicardial local electrogram in a patient with idiopathic ventricular fibrillation.

    Kamikubo Y, Inden Y, Nagao T, Aizawa Y, Murohara T

    HeartRhythm case reports   Vol. 3 ( 9 ) page: 427 - 430   2017.9

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    DOI: 10.1016/j.hrcr.2017.06.010

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  89. Vagal response in cryoballoon ablation of atrial fibrillation and autonomic nervous system: Utility of epicardial adipose tissue location

    Yanagisawa Satoshi, Inden Yasuya, Mizutani Yoshiaki, Fujii Aya, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Funabiki Junya, Murase Yosuke, Takenaka Masaki, Otake Noriaki, Hattori Tetsuyoshi, Shibata Rei, Murohara Toyoaki

    JOURNAL OF ARRHYTHMIA   Vol. 33 ( 4 ) page: 275 - 282   2017.8

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    DOI: 10.1016/j.joa.2017.03.001

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  90. Tachycardia-Induced J-Wave Changes in Patients With and Without Idiopathic Ventricular Fibrillation

    Aizawa Yoshiyasu, Takatsuki Seiji, Nishiyama Takahiko, Kimura Takehiro, Kohsaka Shun, Kaneko Yoshiaki, Inden Yasuya, Takahashi Naohiko, Nagase Satoshi, Aizawa Yoshifusa, Fukuda Keichi

    CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY   Vol. 10 ( 7 )   2017.7

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    DOI: 10.1161/CIRCEP.117.005214

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  91. Impaired renal function is associated with recurrence after cryoballoon catheter ablation for paroxysmal atrial fibrillation: A potential effect of non-pulmonary vein foci

    Yanagisawa Satoshi, Inden Yasuya, Kato Hiroyuki, Fujii Aya, Mizutani Yoshiaki, Ito Tadahiro, Kamikubo Yosuke, Kanzaki Yasunori, Ando Monami, Hirai Makoto, Shibata Rei, Murohara Toyoaki

    JOURNAL OF CARDIOLOGY   Vol. 69 ( 1-2 ) page: 3 - 10   2017.1

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    DOI: 10.1016/j.jjcc.2016.07.008

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  92. An ECG Index of P-Wave Force Predicts the Recurrence of Atrial Fibrillation after Pulmonary Vein Isolation Reviewed

    Kanzaki Y, Inden Y, Ando M, Kamikubo Y, Ito T, Mizutani Y, Kato H, Fujii A, Yanagisawa S, Hirai M, Murohara T

    Pacing Clin Electrophysiol   Vol. 39 ( 11 ) page: 1191-1197   2016.11

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    DOI: 10.1111/pace.12956

  93. Decrease in B-Type Natriuretic Peptide Levels and Successful Catheter Ablation for Atrial Fibrillation in Patients with Heart Failure. Reviewed

    Yanagisawa S, Inden Y, Kato H, Fujii A, Mizutani Y, Ito T, Kamikubo Y, Kanzaki Y, Hirai M, Murohara T

    Pacing Clin Electrophysiol   Vol. 39 ( 3 ) page: 225-234   2016.3

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    DOI: 10.1111/pace.12788

  94. Efficacy and safety of apixaban in the patients undergoing the ablation of atrial fibrillation. Reviewed

    Nagao T, Inden Y, Shimano M, Fujita M, Yanagisawa S, Kato H, Ishikawa S, Miyoshi A, Okumura S, Ohguchi S, Yamamoto T, Yoshida N, Hirai M, Murohara T.

    Pacing Clin Electrophysiol   Vol. 38 ( 2 ) page: 155-63   2015.2

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    DOI: 10.1111/pace.12553.

  95. Clinical characteristics and predictors of super-response to cardiac resynchronization therapy: a combination of predictive factors. Reviewed

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Fujita M, Ohguchi S, Ishikawa S, Kato H, Okumura S, Miyoshi A, Nagao T, Yamamoto T, Hirai M, Murohara T.

    Pacing Clin Electrophysiol.   Vol. 37 ( 11 ) page: 1553-64   2014.11

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    DOI: 10.1111/pace.12506.

  96. Efficacy and safety of radiofrequency catheter ablation for atrial fibrillation in chronic hemodialysis patients

    Hayashi M, Kaneko S, Shimano M, Ohashi T, Kubota R, Takeshita K, Shinoda M, Inden Y, Kanayama H, Murohara T

    Nephrol Dial Transplant   Vol. 29 ( 1 ) page: 160-7   2014.1

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    DOI: 10.1093/ndt/gft233

  97. Clinical outcome of implantable cardioverter defibrillators with recalled and non-recalled leads in Japanese patients

    Yanagisawa S, Inden Y, Shimano M, Yoshida N, Ichiyanagi H, Fujita M, Ohguchi S, Ishikawa S, Kato H, Okumura S, Miyoshi A, Nagao T, Yamamoto T, Hirai M, Murohara T

    Circ J   Vol. 78 ( 2 ) page: 353-9   2014.1

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    DOI: 353-9

  98. Mechanisms with clinical implications for atrial fibrillation-associated remodeling: cathepsin K expression, regulation, and therapeutic target and biomarker

    Fujita M, Cheng XW, Inden Y, Shimano M, Yoshida N, Inoue A, Yamamoto T, Takeshita K, Kyo S, Taguchi N, Shi GP, Kuzuya M, Okumura K, Murohara T

    J Am Heart Assoc   Vol. 2 ( 6 ) page: e000503   2013.12

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    DOI: 10.1161/JAHA.113.000503

  99. Cystatin C as a predictor of mortality and cardiovascular morbidity after cardiac resynchronization therapy

    Yamamoto T, Shimano M, Inden Y, Miyata S, Inoue Y, Yoshida N, Tsuji Y, Hirai M, Murohara T

    Circ J   Vol. 77 ( 11 ) page: 2751-6   2013.8

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    DOI: 2751-6

  100. Physiological Magnetic Stimulation for Arousal of Elderly Car Driver Evaluated With Electro-Encephalogram and Spine Magnetic Field Reviewed

    Kaneo Mohri, Tsuyoshi Uchiyama, MuneoYamada, Yoshiyuki Mohri, K. Endo, T. Suzuki, Yasuya Inden

    IEEE TRANSACTIONS ON MAGNETICS,   Vol. 48 ( 11 ) page: 3505-3508   2012.11

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    DOI: 10.1109/TMAG.2012.2200457

  101. Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.

    Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K.

    Circulation   Vol. 123 ( 20 ) page: 2192-2203   2011.5

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  102. Novel transitional zone index allows more accurate differentiation between idiopathic right ventricular outflow tract and aortic sinus cusp ventricular arrhythmias.

    Yoshida N, Inden Y, Uchikawa T, Kamiya H, Kitamura K, Shimano M, Tsuji Y, Hirai M, Murohara T.

    Heart Rhythm   Vol. 8 ( 3 ) page: 349-356   2011.3

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  103. Electrocardiographic and electrophysiological characteristics in idiopathicventricular arrhythmias originating from the papillary muscles in the leftventricle: relevance for catheter ablation Reviewed

    Yamada T, Doppalapudi H, McElderry HT, Okada T, Murakami Y, Inden Y, YoshidaY, Yoshida N, Murohara T, Epstein AE, Plumb VJ, Litovsky SH, Kay GN

    Circ Arrhythm Electrophysiol   Vol. 3 ( 4 ) page: 324-31   2010.8

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  104. Combined assessment of left ventricular dyssynchrony and contractility by speckled tracking strain imaging: a novel index for predicting responders to cardiac resynchronization therapy Reviewed

    Inden Y, Ito R, Yoshida N, Kamiya H, Kitamura K, Kitamura T, Shimano M, Uchikawa T, Tsuji Y, Shibata R, Hirai M, Murohara T

    Heart Rhythm   Vol. 7 ( 5 ) page: :655-61   2010.5

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  105. *Morphological characteristics of the Holter P-waves associated with pulmonary vein pacing. Reviewed

    Harata S, Inden Y, Shimano M, Uchikawa T, Mutoh M, Hirai M, Murohara T

    Europace   Vol. 12 ( 1 ) page: 124-129   2010.1

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  106. Morphological characteristics of the Holter P-waves associated with pulmonaryvein pacing Reviewed

    Harata S, Inden Y, Shimano M, Uchikawa T, Mutoh M, Hirai M, Murohara T

    Europace   Vol. 12 ( 1 ) page: 124-9   2010.1

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  107. Difference in percentage of ventricular pacing between two algorithms for minimizing ventricular pacing: results of the IDEAL RVP (Identify the Best Algorithm for Reducing Unnecessary Right Ventricular Pacing) study. Reviewed

    Murakami Y, Tsuboi N, Inden Y, Yoshida Y, Murohara T, Ihara Z, Takami M

    Europace   Vol. 12 ( 1 ) page: 96-102   2010.1

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  108. Impact of acarbose on carotid intima-media thickness in patients with newly diagnosed impaired glucose tolerance or mildtype 2 diabetes mellitus: A one-year, prospective, randomized, open-label,parallel-group study in Japanese adults with established coronary artery disease Reviewed

    Koyasu M, Ishii H, Watarai M, Takemoto K, Inden Y, Takeshita K, Amano T,Yoshikawa D, Matsubara T, Murohara T

    Clin Ther   Vol. 32 ( 9 ) page: 1610-7   2010

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  109. The difference in autonomic denervation and its effect on atrial fibrillation recurrence between the standard segmental and circumferential pulmonary vein isolation techniques. Reviewed

    Yamada T, Yoshida N, Murakami Y, Okada T, Yoshida Y, Muto M, Inden Y, Murohara T

    Europace   Vol. 11 ( 12 ) page: 1612-1619   2009.12

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  110. *Reactive oxidative metabolites are associated with atrial conduction disturbance in patients with atrial fibrillation. Reviewed

    Shimano M, Shibata R, Inden Y, Yoshida N, Uchikawa T, Tsuji Y, Murohara T

    Heart Rhythm   Vol. 6 ( 7 ) page: 935-940   2009.4

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  111. Vagal modification can also help prevent late recurrence of atrial fibrillation after segmental pulmonary vein isolation. Reviewed

    Yoshida N, Yamada T, Murakami Y, Okada T, Ninomiya Y, Toyama J, Yoshida Y, Tsuboi N, Muto M, Inden Y, Hirai M, Murohara T

    Circ J   Vol. 73 ( 4 ) page: 632-638   2008.12

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  112. Circulating homocysteine levels in patients with radiofrequency catheter ablation for atrial fibrillation. Europace. Reviewed

    Shimano M, Inden Y, Tsuji Y, Kamiya H, Uchikawa T, Shibata R, Murohara T

    Europace   Vol. 10 ( 8 ) page: 961-966   2008.8

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  113. Circulating adiponectin levels in patients with atrial fibrillation. Reviewed

    Shimano M, Shibata R, Tsuji Y, Kamiya H, Uchikawa T, Harata S, Muto M, Ouchi N, Inden Y, Murohara T

    Circ J   Vol. 72 ( 7 ) page: 1120-1124   2008.7

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  114. *Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failure.

    Shimano M, Tsuji Y, Inden Y, Kitamura K, Uchikawa T, Harata S, Nattel S, Murohara T

    Heart Rhythm   Vol. 5 ( 3 ) page: 451-459   2008.3

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  115. Electrophysiologic characteristics and outcome of segmental ostial superior vena cava isolation in patients with paroxysmal atrial fibrillation initiated by superior vena cava ectopy: comparison with pulmonary vein isolation. Reviewed

    Muto M, Yamada T, Murakami Y, Okada T, Okamoto M, Shimizu T, Toyama J,Yoshida Y, Tsuboi N, Ito T, Kondo T, Inden Y, Hirai M, Murohara T

    J Electrocardiol   Vol. 40 ( 4 ) page: 319-325   2007.10

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  116. Prevalence and severity of left atrial edema detected by electron beam tomography early after pulmonary vein ablation. Reviewed

    Okada T, Yamada T, Murakami Y, Yoshida N, Ninomiya Y, Shimizu T, Toyama J, Yoshida Y, Ito T, Tsuboi N, Kondo T, Inden Y, Hirai M, Murohara T

    J Am Coll Cardiol   Vol. 49 ( 13 ) page: 1436-1442   2007.4

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  117. Does RV lead positioning provide additional benefit to cardiac resynchronization therapy in patients with advanced heart failure? Reviewed

    Shimano M, Inden Y, Yoshida Y, Tsuji Y, Tsuboi N, Okada T, Yamada T, Murakami Y, Takada Y, Hirayama H, Murohara T

    Pacing Clin Electrophysiol   Vol. 29 ( 10 ) page: 1069-1074   2006

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  118. Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Reviewed

    Takeshita K, Fujimori T, Kurotaki Y, Honjo H, Tsujikawa H, Yasui K, Lee JK,Kamiya K, Kitaichi K, Yamamoto K, Ito M, Kondo T, Iino S, Inden Y, Hirai M,Murohara T, Kodama I, Nabeshima Y

    Circulation   Vol. 109 ( 14 ) page: 1776-17782   2004.4

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  119. Diagnostic usefulness of postexercise systolic blood pressure response for detection of coronary artery disease in patients with echocardiographic left ventricular hypertrophy Reviewed

    Yamada K, Hirai M, Abe K, Ishihara H, Takeshita K, Takada Y, Mutoh M, Noda H, Shimizu A, Shibata Y, Yamada T, Kondo T, Yoshida Y, Inden Y, Murohara T

    Can J Cardiol   Vol. 20   page: 705-711   2004

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  120. Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers Reviewed

    Kondo T, Hayashi M, Takeshita K, Numaguchi Y, Kobayashi K, Iino S, Inden Y, Murohara T

    Arterioscler Thromb Vasc Biol   Vol. 24   page: 1442-1447   2004

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  121. *Ionic mechanisms of acquired QT prolongation and torsades de pointes in rabbits with chronic complete atrioventricular block. Reviewed

    Tsuji Y, Opthof T, Yasui K, Inden Y, Takemura H, Niwa N, Lu Z, Lee JK, Honjo H, Kamiya K, Kodama I

    Circulation   Vol. 106 ( 15 ) page: 2012-2018   2002.10

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  122. Repetitive atrial flutter as a complication of the left-sided simple maze procedure. Reviewed

    Usui A, Inden Y, Mizutani S, Takagi Y, Akita T, Ueda Y

    Ann Thorac Surg   Vol. 73 ( 5 ) page: 1457-1459   2002.5

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  123. Changes in repolarization properties with long-term cardiac memory modify dispersion of repolarization in patients with Wolff-Parkinson-White syndrome. Reviewed

    akada Y, Inden Y, Akahoshi M, Shibata Y, Shimizu A, Yoshida Y, Yamada T, Tsuboi N, Hirayama H, Ito T, Kondo T, Saito H, Hirai M

    J Cardiovasc Electrophysiol   Vol. 13 ( 4 ) page: 324-330   2002.4

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  124. *Prolongation of activation-recovery interval over a preexcited region before and after catheter ablation in patients with Wolff-Parkinson-White syndrome. Reviewed

    Inden Y, Hirai M, Takada Y, Shimizu A, Shimokata K, Yoshida Y, Akahoshi M,Kondo T, Saito H

    J Cardiovasc Electrophysiol   Vol. 12 ( 8 ) page: 933-945   2001.4

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  125. Antiarrhythmic efficacy of dipyridamole in treatment of reperfusion arrhythmias : evidence for cAMP-mediated triggered activity as a mechanism responsible for reperfusion arrhythmias. Reviewed

    Yoshida Y, Hirai M, Yamada T, Tsuji Y, Kondo T, Inden Y, Akahoshi M, MurakamiY, Tsuda M, Tsuboi N, Hirayama H, Okamoto M, Ito T, Saito H, Toyama J

    Circulation   Vol. 101 ( 6 ) page: 624-630   2000.2

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  126. Relationship between Joint National Committee-VI classification of hypertension and ambulatory blood pressure in patients with hypertension diagnosed by casual blood pressure. Reviewed

    Inden Y, Tsuda M, Hayashi H, Takezawa H, Iino S, Kondo T, Yoshida Y, Akahoshi M, Terasawa M, Itoh T, Saito H, Hirai M

    Clin Cardiol   Vol. 21 ( 11 ) page: 801-806   1998.11

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  127. Body-surfacedistribution of changes in activation-recovery intervals before and after catheter ablation in patients with Wolff-Parkinson-White syndrome: clinical evidence for ventricular 'electrical remodeling' with prolongation of action-potential duration over a preexcited area. Reviewed

    Akahoshi M, Hirai M, Inden Y, Sano H, Shimizu A, Kondo T, Makino M, Horiba M,Yoshida Y, Tsuboi N, Hirayama H, Ito T, Hayashi H, Saito H

    Circulation   Vol. 96 ( 5 ) page: 1566-1574   1997.9

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  128. Body surface distribution of abnormally low QRST areas in patients with Wolff-Parkinson-White syndrome. Evidence for continuation of repolarization abnormalities before and after catheter ablation. Reviewed

    Hirai M, Tsuboi N, Hayashi H, Ito M, Inden Y, Hirayama H, Ito T, Yanagawa T, Sano H, Kondo T, et al

    Circulation   Vol. 88 ( 6 ) page: 2674-2684   1993.12

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Presentations 6

  1. A Novel Combined Assessment of Left Ventricular Dyssynchrony and Contractility by Radial Strain Echocardiography Predicts Responders to Cardiac Resynchronization Therapy International conference

    第82回American Heart Association Scientific Sessions 

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    Event date: 2009.11

    Language:English   Presentation type:Oral presentation (general)  

  2. Bepridil Magnifies Left-to-Right Atrial Frequency Gradient in Chronic Atrial Fibrillation

    The 71st Annual Scientific Meeting of the Japanese Circulation Society 

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    Event date: 2007.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  3. Atrial Fibrillation is Associated with Collagen Type I Synthesis in Patients without Organic Heart Disease International conference

    Heart Rhythm Society 2006 

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    Event date: 2006.5

    Language:English   Presentation type:Oral presentation (general)  

  4. Paroxysmal Atrial Fibrillation Terminates by Pilsicainide through Attenuation of Left-to-Right Atrial Frequency Gradient

    The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society 

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    Event date: 2006.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  5. Novel ECG parameters during atrial fibrillation predict th possibility of conversion by the infusion of pilsicainide International conference

    Heart Rhythm Society 2005 

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    Event date: 2005.5

    Language:English   Presentation type:Oral presentation (general)  

  6. Atrial Fibrillation is Associated with Collagen Type I Synthesis in Patients without Organic Heart Disease

    The 69th Annual Scientific Meeting of the Japanese Circulation Society 

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    Event date: 2005.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. PPARγアゴニストおよびMMP阻害薬による心筋線維化抑制作用と不整脈抑制作用

    2006

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 頸動脈波の微小栓子シグナル信号解析を用いた、有効で安全な次世代不整脈治療法の確立

    Grant number:23K07549  2023.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    柳澤 哲, 因田 恭也

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    本研究は、微小栓子を描出可能な専用の頸動脈ドップラー血流超音波装置を用いて、不整脈アブレーション治療における潜在的脳梗塞のリスクを評価することである。そして、新しい手技法や出力エネルギーの違い、アプローチ法、術中の抗凝固管理等様々な視点から塞栓リスクを評価し、より安全で有効な不整脈治療・予防法を確立することにある。さらに、検出された微小栓子と凝固機能活性化や高次脳機能への影響を評価する。

  2. 非可逆的電気穿孔法の出力設定最適化と心室性不整脈治療への応用に関する検討

    Grant number:22K08177  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    因田 恭也, 辻 幸臣

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    Authorship:Principal investigator 

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    カテーテルアブレーションにおける高周波に代わるエネルギー源として電界パルスを用いた非可逆的電気穿孔法が考案された。本法はその通電設定により心筋に特異的な障害を加えることが可能で、本法による心房細動治療の実験的検討が行われ、さらに臨床応用が始まろうとしている。しかし、これまでの報告では、電界パルスの幅、回数、頻度、電界などの条件は十分に検討されておらず、また心室性不整脈に対する治療効果は不明である。本研究の目的は、電界パルスを用いた非可逆的電気穿孔法の設定条件を心筋及び周囲組織の組織学的な検討を踏まえ検討し、さらに心室頻拍心室細動などの難治性不整脈に対する治療効果を実験的に検討することである。
    本研究の目的は、電界パルスを用いた非可逆的電気穿孔法の設定条件を心筋及び周囲組織の組織学的な検討を踏まえ検討し、さらに心室頻拍心室細動などの難治性不整脈に対する治療
    効果を実験的に検討することである。
    まず、この研究にはパルス電界発生装置が必要である。非可逆的電気穿孔法に使用するパルス電界発生装置の製作を依頼したところ、その完成に時間がかかり、2023年3月にようやく装置が完成した。しかし、パルス電界の幅、頻度などの設定に問題があり、現在装置を修理中である。そのため本装置を用いての実験検討はこれから始めるところである。パルス幅は100マイクロsecと狭いdurationから設定可能であり、二相性の波形も設定でき、心電図同期も可能で、頻度などの設定調節も可能である。今後ウサギ筋肉にて検討を行う。
    そのため、本装置が到着するまでの間、遺伝子導入に用いるパルス電界発生装置を用いて、肉片にて通電効果を確かめているところである。この装置は我々が予定していた1000Vでなく、300V程度の出力のみで、出力が弱く、パルス幅や頻度も異なっており、十分な効果が期待できないものの、パルスの条件による効果の違いを検討し得ると考えた。数例の検討であるが、心筋焼灼可能であり、心筋に非可逆的なダメージの作成が確認された。また房室結節付近への通電により、心拍数の減少が確認され、房室ブロック作成可能であることも確認された。現在、焼灼した心筋の組織学的検討も行っている。
    パルス電界発生装置作成に予定以上の時間がかかったため。当初予定していた実験が行うことができていない。
    パルス電界発生装置は、すでにほぼ完成に近く、数か月以内に手に入る予定である。パルス幅、パルス間隔、パルス回数、パルス波形(単相性/二相性)、電界の大きさを可変できる仕様の機器であり、ウサギ心室筋での最適な通電条件を検討する予定手ある。。

  3. 治療抵抗性致死的不整脈に対する定位放射線治療の研究

    Grant number:21K07725  2021.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    川村 麻里子, 因田 恭也, 駒田 智大

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    Authorship:Coinvestigator(s) 

    器質的心疾患に伴う心室頻拍(VT)はしばしば難治性である。国外を中心に、この難治性なVTに対する放射線を用いた非侵襲的アブレーション治療の臨床試験が行われ、短期的には良好な結果が報告されている。本研究では海外での研究成果を基盤に、国内の診療体制でも実現可能な方法へ変換し、高精度定位放射線治療によるアブレーション治療技術を開発するものである。本治療が本邦でも施行可能となることで、現在治療法がなく、突然死の恐怖と日々戦っている患者の希望となると確信している。
    本研究の目標は海外での治療実績が既に複数報告される、カテーテルアブレーションでの治癒が困難なVT患者に対する定位放射線治療技術を用いたアブレーションを国内で施行可能な方法で実現することである。昨年度は主に、国内外の先行施設見学やミーティングを介して具体的な臨床試験開始に向けた準備を開始した。具体的には、まず、使用した放射線治療装置は異なるものの、国内で、同様に定位放射線照射でVT治療を行う臨床試験を行った先行施設の循環器内科医、放射線治療医、医学物理士とミーティングを行い、実際の照射後の経過やターゲットの決定方法など意見交換を行った。次に、海外では多施設臨床試験が開始され、複数のプロトコル論文も発表されていることからそれらを参考にプロトコル作成を開始すると同時に、当院と同じ放射線治療装置、計画装置、マッピング装置を使用している先行施設(チェコとスイスの先行施設)に循環器内科医の共同研究者と共に施設見学に行き、治療の詳細について症例検討など行った。更に、実際の治療を行う場合の協力も取り付けた。
    マッピングデータとCTの融合が一つの問題点であったが、先行施設で使用しているフリーソフトの紹介を受け、ある程度画像融合の目処はたった。現在、先行施設の物理士と共同研究者の物理士で細かい調整を行っているところではあるが、必要検査、計画作成に必要な情報は揃ったため、先行施設見学後にプロトコルの最終打ち合わせを共同研究者と行い、臨床試験開始に向けた最終段階に達している。
    令和5年度中には特定臨床研究が開始できる目処が立っており、概ね順調に進んでいる、あるいは当初の計画以上に進展していると考える。
    令和5年早々には特定臨床試験が開始できそうである。特定臨床試験を開始するにあたり、科研費のみでは研究費用がカバーできない恐れがあったが、別の研究助成を受けることで臨床試験の実施まで可能となりそうである。しかし、試験開始前にも関わらず、既に他の治療法がなく、本臨床試験を待っている患者が複数名いることから、特定臨床試験で予定する3例治療後について、検討していかなくてはならない。

  4. Evaluation by Frequency Analysis of Surface Electrocardiogram and Rotor Mapping in Left Atrum

    Grant number:15K09076  2015.4 - 2018.3

    Yasuya Inden

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Dominant frequency (DF) of atrial fibrillation (AF) reflects atrial electrical activity. We retrospectively investigated 78 patients who underwent catheter ablation due to persistent AF. The high DF of lead aVL and V1 was a predictor of arrhythmia recurrence after persistent AF ablation.
    Electrical rotors may be targets in ablations for persistent atrial fibrillation. Unipolar electrograms in left atrium were recorded with using basket catheter, and we analyzed rotational activities by NavX. rotors were recognized in anterior and posterior LA. We performed PV isolation and delivered RF application to the rotors. AF terminated in some patients and more patients maintained sinus rhythm. Rotors could be able to be recognized by use of basket catheter and EnSite system in patients with persistent AF and may be the target of ablation in persistent AF next to PVI.

  5. Exploratory research of microscopic myocardial injury by irradiation using averaged electrocardiogram

    Grant number:26461883  2014.4 - 2018.3

    Tohru Okada

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    Authorship:Coinvestigator(s) 

    In this study, to explore myocardial damage due to irradiation, we use averaged electrocardiogram that can identify microscopic myocardial injury. Interventions other than the above were judged to deviate from regular medical practice, therefore this study was approved in our hospital as a prospective clinical trial considerably later than the original schedule. About 40% of the case arrival number (30 cases) was accumulated and analyzed as much as possible this time. No significant change was observed by irradiation with fQRS-d, RMS 40ms, LAS 40μV which are indicators of the averaged electrocardiogram. In E/e’ which is an index of diastolic cardiac function at echocardiogram, an upward trend was observed after 6 months of irradiation, although a statistically significant difference was not observed. This study will continue as an in-hospital clinical trial and accumulate cases and plan to reanalyze as soon as the number of cases is reached.

  6. Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation-promotion

    2006.4 - 2008.3

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(C)

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 11

  1. 循環器内科

    2022

  2. 循環器内科選択講義

    2022

  3. 循環器

    2021

  4. 循環器内科

    2023

  5. 循環器内科選択講義

    2023

  6. 循環器内科ポリクリ実習

    2023

  7. 循環器内科ポリクリ実習

    2022

  8. 循環器

    2021

  9. 循環器ポリクリ

    2021

  10. 循環器

    2020

  11. 循環器

    2020

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