Updated on 2026/07/29

写真a

 
KAJIYAMA, Hiroaki
 
Organization
Graduate School of Medicine Program in Integrated Medicine Medicine in Growth and Aging Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor
Contact information
メールアドレス

Degree 1

  1. 医博 ( 2002.6   名古屋大学 ) 

Research Interests 1

  1. Gynecologic Oncology

Research Areas 1

  1. Others / Other  / Obstetrics and Gynecology

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    1999.4 - 2002.6

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1989.4 - 1995.3

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    Country: Japan

Professional Memberships 8

  1. 日本産科婦人科学会

  2. 日本癌治療学会

  3. 日本癌学会

  4. 日本婦人科腫瘍学会

  5. 日本東洋医学会

  6. 日本緩和医療学会

  7. 日本臨床細胞学会

  8. 日本臨床腫瘍学会

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Awards 1

  1. 日本産科婦人科学会学術奨励賞

    2007.4   日本産科婦人科学会  

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    Country:Japan

 

Papers 510

  1. *Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary? Reviewed

    Kajiyama H, Shibata K, Suzuki S, Ino K, Yamamoto E, Mizuno K, Sakakibara K, Matsuzawa K, Takeda A, Kinoshita Y, Kawai M, Nagasaka T, Nawa A, Kikkawa F.

      Vol. 111 ( 3 ) page: 523-6   2008.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ygyno.2008.04.001

  2. *Is there any association between retroperitoneal lymphadenectomy and survival benefit in ovarian clear cell carcinoma patients? Reviewed

    Suzuki S, Kajiyama H, Shibata K, Ino K, Nawa A, Sakakibara K, Matsuzawa K, Takeda A, Kinoshita Y, Kawai M, Nagasaka T, Kikkawa F.

    Ann Oncol.   Vol. 19 ( 7 ) page: 1284-7   2008.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  3. Stromal cell-derived factor-1alpha-induced cell proliferation and its possible regulation by CD26/dipeptidyl peptidase IV in endometrial adenocarcinoma. Reviewed

    Mizokami Y, Kajiyama H, Shibata K, Ino K, Kikkawa F, Mizutani S.

    Int J Cancer   Vol. 110 ( 5 ) page: 652-9   2004.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  4. Possible involvement of SDF-1alpha/CXCR4-DPPIV axis in TGF-beta1-induced enhancement of migratory potential in human peritoneal mesothelial cells. Reviewed

    Kajiyama H, Shibata K, Ino K, Nawa A, Mizutani S, Kikkawa F

    Cell Tissue Res.   Vol. 330 ( 2 ) page: 221-9   2007.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  5. Twist Expression Predicts Poor Clinical Outcome of Patients with Clear Cell Carcinoma of the Ovary. Reviewed

    Kajiyama H, Hosono S, Terauchi M, Shibata K, Ino K, Yamamoto E, Nomura S, Nawa A, Kikkawa F

    Oncology   Vol. 71 ( 5 ) page: 394-401   2007.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000107108

  6. Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells. Reviewed

    Kajiyama H, Shibata K, Terauchi M, Yamashita M, Ino K, Nawa A, Kikkawa F.

    Int J Oncol   Vol. 31 ( 2 ) page: 277-83   2007.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/carcin/22.9.1429

  7. Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo. Reviewed

    Yamashita M, Kajiyama H, Terauchi M, Shibata K, Ino K, Nawa A, Mizutani S, Kikkawa F

    Int J Cancer.   Vol. 120 ( 10 ) page: 2243-50   2007.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ijc.22528

  8. Expression of Twist increases the risk for recurrence and for poor survival in epithelial ovarian carcinoma patients. Reviewed

    Hosono S, Kajiyama H, Terauchi M, Shibata K, Ino K, Nawa A, Kikkawa F

    Br J Cancer.   Vol. 96 ( 2 ) page: 314-20   2007.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.bjc.6603533

  9. Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells Reviewed

    Kajiyama H, Shibata K, Terauchi M, Ino K, Nawa A, Kikkawa F.

    Ann N Y Acad Sci   Vol. 1086   page: 233-40   2006.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1196/annals.1377.007

  10. Anti-progressive effect of neutral endopeptidase 24.11 (NEP/CD10) on cervical carcinoma in vitro and in vivo. Reviewed

    Terauchi M, Kajiyama H, Shibata K, Ino K, Mizutani S, Kikkawa F.

    Oncology   Vol. 69 ( 1 ) page: 52-62   2005.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000087476

  11. Neutral endopeptidase 24.11/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo. Reviewed

    Kajiyama H, Shibata K, Terauchi M, Morita T, Ino K, Mizutani S, Kikkawa F.

    Clin Cancer Res.   Vol. 11 ( 5 ) page: 1798-808   2005.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/1078-0432.CCR-04-2395

  12. *Involvement of SDF-1alpha/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma. Reviewed

    Kajiyama H, Shibata K, Terauchi M, Ino K, Nawa A, Kikkawa F.

    Int J Cancer   Vol. 122 ( 1 ) page: 91-9   2008.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  13. Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells. Reviewed

    Kajiyama H, Kikkawa F, Khin E, Shibata K, Ino K, Mizutani S.

    Cancer Res.   Vol. 63 ( 9 ) page: 2278-83   2003.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  14. *Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma. Reviewed

    Kajiyama H, Kikkawa F, Suzuki T, Shibata K, Ino K, Mizutani S.

    Cancer Res.   Vol. 62 ( 10 ) page: 2753-7   2002.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  15. Fertility-sparing surgery in patients with clear-cell carcinoma of the ovary: is it possible? Reviewed

    Kajiyama H, Shibata K, Mizuno M, Hosono S, Kawai M, Nagasaka T, Kikkawa F.

    Hum Reprod.   Vol. 26 ( 12 ) page: 3297-302   2101.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  16. Association of germline BRCA and homologous recombination deficiency with hematologic toxicity during platinum-taxane chemotherapy in ovarian cancer.

    Yoshida K, Araki H, Yamada Y, Masahashi Y, Miyamoto E, Katayama K, Kubokawa M, Mogi K, Yoshihara M, Nagao Y, Tamauchi S, Yokoi A, Yoshikawa N, Niimi K, Kajiyama H

    International journal of clinical oncology   Vol. 31 ( 8 ) page: 1576 - 1586   2026.8

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    DOI: 10.1007/s10147-026-03065-4

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  17. Therapy-related myeloid neoplasms following treatment for high-risk gestational trophoblastic neoplasia: a case series and retrospective analysis.

    Niimi K, Yamamoto E, Yoshida K, Yasui Y, Kajiyama H

    International journal of clinical oncology   Vol. 31 ( 8 ) page: 1628 - 1635   2026.8

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    DOI: 10.1007/s10147-026-03073-4

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  18. Transcriptome profiling identifies RET activation as a therapeutic target in gastric-type endocervical adenocarcinoma.

    Yamada H, Yokoi A, Suzuki K, Yoshida K, Kitagawa M, Asano-Inami E, Suzuki H, Araki H, Ochi M, Inoue N, Sanada S, Kiyono T, Yamamoto Y, Tsuda N, Kajiyama H

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie   Vol. 201   page: 119696   2026.8

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    DOI: 10.1016/j.biopha.2026.119696

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  19. Longitudinal BMI Trajectory in Reproductive-Age Women at Risk of Prediabetes: Implications for Preventive Screening.

    Tano S, Fuma K, Matsuo S, Katsuki S, Inamura T, Fujito S, Kajiyama H, Ushida T

    American journal of preventive medicine     page: 108525   2026.7

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    DOI: 10.1016/j.amepre.2026.108525

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  20. Drug library screening identifies colchicine and shikonin as therapeutic candidates for methotrexate-resistant choriocarcinoma.

    Nishiko Y, Yoshida K, Yokoi A, Kitagawa M, Inami E, Yasui Y, Ishikawa T, Mizushima T, Yoshihara M, Mogi K, Nagao Y, Tamauchi S, Yoshikawa N, Yamamoto E, Niimi K, Kajiyama H

    Biochemical and biophysical research communications   Vol. 831   page: 154317   2026.7

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    DOI: 10.1016/j.bbrc.2026.154317

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  21. Clinical experience with de-escalated chemotherapy for a subset of high-risk gestational trophoblastic neoplasia at a single institution.

    Yoshida K, Yoshida T, Shirasaki M, Yasui Y, Yamamoto E, Niimi K, Kajiyama H

    International journal of clinical oncology     2026.6

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    DOI: 10.1007/s10147-026-03105-z

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  22. Extracellular vesicles in nipple discharge for breast cancer screening.

    Ozaki Y, Yoshida K, Ichikawa T, Kitagawa M, Kato M, Velaga R, Iwase M, Takano Y, Takeuchi D, Kikumori T, Murata K, Yasui T, Nagahashi M, Ebata T, Kajiyama H, Masuda N, Yokoi A

    Breast cancer research and treatment   Vol. 217 ( 3 )   2026.6

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    DOI: 10.1007/s10549-026-07975-9

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  23. Blood pressure trajectories during pregnancy, labor, and postpartum period: a multicenter study in Japan.

    Ushida T, Shimaya T, Inamura T, Katsuki S, Tano S, Matsuo S, Fuma K, Yoshida S, Yamashita M, Kajiyama H

    Hypertension research : official journal of the Japanese Society of Hypertension     2026.6

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    DOI: 10.1038/s41440-026-02708-3

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  24. Emerging signal transduction pathways and the role of bacterial extracellular vesicles linked to the pathogenesis of endometriosis.

    Muraoka A, Yokoi A, Kajiyama H

    Communications medicine   Vol. 6 ( 1 )   2026.6

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    DOI: 10.1038/s43856-026-01704-5

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  25. Integrated immunophenotypic and ProMisE molecular profiling as predictors of immune checkpoint inhibitor response in recurrent endometrial cancer.

    Katayama K, Yoshikawa N, Liu W, Nakamura K, Hattori S, Kubokawa M, Iyoshi S, Yoshida K, Yoshihara M, Nagao Y, Tamauchi S, Yokoi A, Niimi K, Shimizu Y, Kawai Y, Utsumi F, Watanabe E, Suzuki S, Shibata K, Kajiyama H

    Cancer immunology, immunotherapy : CII     2026.6

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    DOI: 10.1007/s00262-026-04414-y

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  26. Impact of Sarcopenia and Pretreatment Skeletal Muscle Loss on Survival in Endometrial Cancer Patients Treated With Immune Checkpoint Inhibitors.

    Katayama K, Yoshikawa N, Nonoyama K, Hattori S, Yoshida K, Yoshihara M, Tamauchi S, Yokoi A, Niimi K, Kajiyama H

    The journal of obstetrics and gynaecology research   Vol. 52 ( 6 ) page: e70362   2026.6

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    DOI: 10.1111/jog.70362

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  27. Optimal adjuvant strategy in intermediate-risk cervical cancer: a systematic review and meta-analysis.

    Yokoi A, Machida H, Okazawa-Sakai M, Nishino K, Nishino H, Itoi M, Mitamura T, Isohashi F, Tsuchida K, Saji H, Fujiwara S, Ii N, Watanabe M, Nishikawa T, Nakagawa S, Kodama M, Sato S, Takehara K, Morisada T, Noda SE, Takekuma M, Kajiyama H, Tokunaga H, Baba T, Kobayashi Y, Okamoto A

    International journal of clinical oncology   Vol. 31 ( 6 ) page: 1084 - 1095   2026.6

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    DOI: 10.1007/s10147-026-03028-9

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  28. Rapid Enlargement of Vulvar Glomus Tumor After Needle Aspiration and Tumor Base Ligation.

    Nagao Y, Tamauchi S, Yokoi A, Yoshikawa N, Niimi K, Kajiyama H

    The journal of obstetrics and gynaecology research   Vol. 52 ( 6 ) page: e70373   2026.6

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    DOI: 10.1111/jog.70373

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  29. Proteomic profiling identifies circulating soluble MCAM/CD146 as a candidate biomarker for abnormal semen parameters in male infertility.

    Kikuchi R, Shibata T, Nakatochi M, Sei H, Kobayashi Y, Kidoya H, Muramatsu F, Furusawa N, Kano K, Mishiro-Sato E, Ishida H, Katagiri Y, Suzuki A, Matsubara H, Takano K, Furui T, Kajiyama H, Okura H

    Annals of clinical biochemistry     page: 45632261454320   2026.5

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    DOI: 10.1177/00045632261454320

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  30. Changes in Epithelial Ovarian Cancer Treatment and Advent of Maintenance Therapy From Real-World Data.

    Miyamoto E, Mogi K, Yoshihara M, Iyoshi S, Uno K, Fujimoto H, Kunishima A, Yoshikawa M, Kitami K, Yoshikawa N, Kajiyama H

    The journal of obstetrics and gynaecology research   Vol. 52 ( 5 ) page: e70268   2026.5

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    DOI: 10.1111/jog.70268

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  31. DNA Copy Number Profiling in Extracellular Vesicles as Clinical Biomarkers of High-Grade Serous Ovarian Carcinoma.

    Uekusa R, Yokoi A, Ukai M, Yoshida K, Chattrairat K, Yasui T, Inokuma Y, Kitagawa M, Asano-Inami E, Yoshihara M, Tamauchi S, Yoshikawa N, Niimi K, Matsuzaki J, Ochiya T, Sood AK, Yamamoto Y, Kajiyama H

    Journal of extracellular vesicles   Vol. 15 ( 5 ) page: e70308   2026.5

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    DOI: 10.1002/jev2.70308

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  32. Correction: In vitro differentiation of the hypothalamic KNDy neuron, a master regulator for reproduction, from mouse embryonic stem cells.

    Miyake N, Suga H, Osuka S, Seki T, Sonehara R, Muraoka A, Nakamura T, Bayasula, Miwata T, Soen M, Sakakibara M, Go S, Hasegawa S, Inoue N, Uenoyama Y, Tsukamura H, Arima H, Kajiyama H

    Reproductive biology and endocrinology : RB&E   Vol. 24 ( 1 )   2026.4

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    DOI: 10.1186/s12958-026-01557-6

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  33. In-Tumor CRISPR-Cas9 Knockout Screening and Novel Therapy Development for Malignant Transformation of Ovarian Teratoma.

    Tamauchi S, Yoshida K, Xinyuan W, Nakagawa A, Yokoi A, Yoshikawa N, Niimi K, Yamamoto Y, Kajiyama H

    Cancer science   Vol. 117 ( 4 ) page: 983 - 995   2026.4

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    DOI: 10.1111/cas.70315

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  34. Facility-Level Factors Associating Antenatal Corticosteroid Administration Rates and Subsequent Term Birth Rates: A Nationwide Cross-Sectional Observational Study Using the 2020-2022 Perinatal Registry Database in Japan.

    Fuma K, Ushida T, Imaizumi T, Tano S, Matsuo S, Katsuki S, Imai K, Kajiyama H, Kotani T

    The journal of obstetrics and gynaecology research   Vol. 52 ( 3 ) page: e70237   2026.3

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    DOI: 10.1111/jog.70237

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  35. Hypertensive disorders of pregnancy and retinopathy of prematurity in extremely preterm infants: A causal mediation analysis.

    Katsuki S, Ushida T, Nakatochi M, Kobayashi Y, Tano S, Matsuo S, Imai K, Sato Y, Hayakawa M, Kajiyama H, Kotani T, Neonatal Research Network of Japan

    Pregnancy hypertension   Vol. 43   page: 101410   2026.3

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    DOI: 10.1016/j.preghy.2025.101410

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  36. In vitro differentiation of the hypothalamic KNDy neuron, a master regulator for reproduction, from mouse embryonic stem cells.

    Miyake N, Suga H, Osuka S, Seki T, Sonehara R, Muraoka A, Nakamura T, Bayasula, Miwata T, Soen M, Sakakibara M, Go S, Hasegawa S, Inoue N, Uenoyama Y, Tsukamura H, Arima H, Kajiyama H

    Reproductive biology and endocrinology : RB&E   Vol. 24 ( 1 )   2026.2

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    DOI: 10.1186/s12958-026-01536-x

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  37. Positive ascites cytology in interval debulking surgery predicts poor outcomes of advanced epithelial ovarian cancer achieving complete tumor resection.

    Yoshikawa M, Yoshihara M, Emoto R, Matsui S, Kajiyama H

    Scientific reports   Vol. 16 ( 1 )   2026.2

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    DOI: 10.1038/s41598-026-37664-y

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  38. Mesothelial cells promote peritoneal invasion and metastasis of ascites-derived ovarian cancer cells through spheroid formation.

    Uno K, Yoshihara M, Yamakita Y, Kitami K, Iyoshi S, Sugiyama M, Koya Y, Kanayama T, Sahara H, Nomura S, Mogi K, Miyamoto E, Fujimoto H, Yoshida K, Tamauchi S, Yokoi A, Yoshikawa N, Niimi K, Shiraki Y, Sjölund J, Oguchi H, Pietras K, Enomoto A, Nawa A, Tomita H, Kajiyama H

    Science advances   Vol. 12 ( 6 ) page: eadu5944   2026.2

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    DOI: 10.1126/sciadv.adu5944

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  39. Current Status of Fertility-Sparing Treatment for Gynecological Cancers in Japan: A Nationwide Survey.

    Shikama A, Nishio H, Okugawa K, Kajiyama H, Suzuki N, Fujiwara H, Watari H, Komatsu H, Yamagami W, Satoh T, Kawana K, Kato K

    The journal of obstetrics and gynaecology research   Vol. 52 ( 2 ) page: e70187   2026.2

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    DOI: 10.1111/jog.70187

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  40. Differential Proteomics of Large Extracellular Vesicles in Ovarian Cancer.

    Suzuki K, Yamamoto Y, Kitagawa M, Asano-Inami E, Yoshida K, Kajiyama H, Yokoi A

    Proteomics   Vol. 26 ( 2-3 ) page: 95 - 104   2026.2

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    DOI: 10.1002/pmic.70054

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  41. Gestational Age-Dependent Effects of Antenatal Magnesium Sulfate on Fetal S100B Levels: An Observational Study Using Cord Serum.

    Shimaya T, Fuma K, Tano S, Matsuo S, Ushida T, Imai K, Kajiyama H, Kotani T

    The journal of obstetrics and gynaecology research   Vol. 52 ( 2 ) page: e70208   2026.2

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    DOI: 10.1111/jog.70208

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  42. Natural-killer-cell-dominant immune landscape and HLA-E-mediated immune evasion in choriocarcinoma.

    Shibata M, Yoshida K, Yasui Y, Nishiko Y, Hattori S, Nakamura K, Koya Y, Yamamoto Y, Suzuki K, Yoshihara M, Nagao Y, Tamauchi S, Yokoi A, Yoshikawa N, Nishino K, Yamamoto E, Niimi K, Kajiyama H

    Placenta   Vol. 174   page: 9 - 18   2026.2

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    DOI: 10.1016/j.placenta.2025.11.012

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  43. Towards building a meaningful clinical training program: a comparison of obstetrics and gynecology undergraduate medical education in Germany and Japan.

    Yoshihara M, Roisenwasser L, Fehm TN, Nishigori H, Kajiyama H

    Nagoya journal of medical science   Vol. 88 ( 1 ) page: 170 - 177   2026.2

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    DOI: 10.18999/nagjms.88.1.170

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  44. LIMCH1-enriched extracellular vesicles promote vascular permeability in early-onset preeclampsia.

    Matsuo S, Yokoi A, Ushida T, Yoshida K, Suzuki H, Kitagawa M, Asano-Inami E, Yamada H, Miki R, Tano S, Imai K, Nagata I, Kawaguchi S, Yasui T, Yamamoto Y, Kajiyama H, Kotani T

    Science advances   Vol. 12 ( 5 ) page: eaeb8806   2026.1

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    DOI: 10.1126/sciadv.aeb8806

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  45. Risk factors for recurrent cases of early-stage uterine sarcoma after complete surgical resection.

    Nagao Y, Yokoi A, Yoshida K, Yoshihara M, Tamauchi S, Yoshikawa N, Niimi K, Kajiyama H

    BMC cancer   Vol. 26 ( 1 )   2026.1

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    DOI: 10.1186/s12885-026-15618-x

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  46. Synergistic use of 1,5-AG and HbA1c for early prediction of gestational diabetes: capturing BMI-dependent glycemic phenotypes.

    Tano S, Inamura T, Fuma K, Matsuo S, Imai K, Katsuki S, Kishigami Y, Oguchi H, Kotani T, Ushida T, Kajiyama H

    Archives of gynecology and obstetrics   Vol. 313 ( 1 ) page: 4   2026.1

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    DOI: 10.1007/s00404-025-08281-3

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  47. Decoding the Follicular Fluid Microenvironment: Integrative Biomarkers and Multiomics Signatures to Predict IVF Outcomes.

    Muraoka A, Kajiyama H

    Reproductive medicine and biology   Vol. 25 ( 1 ) page: e70056   2026.1

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    DOI: 10.1002/rmb2.70056

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  48. Diagnostic Use of the Combination of CA72-4 and Tumor Volume in Mucinous Ovarian Tumors.

    Araki H, Yokoi A, Kuroda K, Suzuki K, Yoshida K, Yoshihara M, Tamauchi S, Yoshikawa N, Niimi K, Kajiyama H

    The journal of obstetrics and gynaecology research   Vol. 52 ( 1 ) page: e70177   2026.1

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    DOI: 10.1111/jog.70177

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  49. Recurrence after Long-Term Use of Poly ADP-Ribose Polymerase Inhibitors Triggered by Therapy-Related Myeloid Neoplasms: A Case Report.

    Yamada Y, Yokoi A, Kajiyama H

    Case reports in oncology   Vol. 19 ( 1 ) page: 841 - 847   2026.1

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    DOI: 10.1159/000552167

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  50. A novel extracellular vesicle isolation method based on cellulose nanofiber sheets.

    Nagao Y, Kajiyama H, Yokoi A

    Extracellular vesicles and circulating nucleic acids   Vol. 7 ( 2 ) page: 535 - 544   2026

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    DOI: 10.20517/evcna.2025.187

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  51. Real-world data-based assessment of therapy-related myeloid neoplasms after poly(ADP-ribose) polymerase inhibitor treatment in ovarian cancer.

    Uekusa R, Yokoi A, Watanabe E, Inoue M, Mizuno K, Yoshida K, Yoshikawa N, Niimi K, Suzuki S, Kajiyama H

    Frontiers in oncology   Vol. 16   page: 1728766   2026

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    DOI: 10.3389/fonc.2026.1728766

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  52. Small-cell carcinoma of the cervix with acute-onset psychotic symptoms associated with clinically diagnosed ectopic ACTH production: a case report.

    Ozaki K, Fujino J, Niimi K, Iwata-Endo K, Otsuka N, Kobayashi T, Yoshida K, Mogi K, Yoshihara M, Nagao Y, Tamauchi S, Yokoi A, Yoshikawa N, Kajiyama H

    Frontiers in oncology   Vol. 16   page: 1684861   2026

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    DOI: 10.3389/fonc.2026.1684861

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  53. Genomic insights and therapeutic efficacy of PARP inhibitors in a high-LOH patient-derived xenograft from malignant transformation of ovarian teratoma.

    Nakagawa A, Tamauchi S, Xinyuan W, Yoshida K, Yokoi A, Yoshikawa N, Niimi K, Kajiyama H

    Biochemical and biophysical research communications   Vol. 792   page: 152979   2025.12

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    DOI: 10.1016/j.bbrc.2025.152979

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  54. Downregulation of Chromosome 19 miRNA Cluster and the Tumor-Suppressive Role of miR-517a-3p in Choriocarcinoma.

    Nishiko Y, Yoshida K, Yasui Y, Yokoi A, Kitagawa M, Inami E, Yoshihara M, Mogi K, Nagao Y, Tamauchi S, Yoshikawa N, Nishino K, Yamamoto E, Niimi K, Kajiyama H

    Cancer science   Vol. 116 ( 12 ) page: 3473 - 3486   2025.12

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    DOI: 10.1111/cas.70207

    PubMed

  55. Impact of neoadjuvant chemotherapy followed by interval debulking surgery on survival in women with advanced non-serous ovarian, fallopian tube, or primary peritoneal cancer.

    Machida H, Kawana K, Okamoto A, Yamagami W, Mandai M, Kajiyama H, Nomura H, Mikami M

    Gynecologic oncology   Vol. 203   page: 8 - 15   2025.12

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    DOI: 10.1016/j.ygyno.2025.10.013

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  56. Maternal Renal Function During Pregnancy and the Early Postpartum Period in Normotensive and Hypertensive Pregnancies.

    Ushida T, Katsuki S, Fuma K, Tano S, Matsuo S, Yoshida S, Yamashita M, Kajiyama H, Kotani T

    The journal of obstetrics and gynaecology research   Vol. 51 ( 12 ) page: e70172   2025.12

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    DOI: 10.1111/jog.70172

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  57. Predicting gestational diabetes before conception for personalized interpregnancy weight management.

    Tano S, Kotani T, Inamura T, Fuma K, Matsuo S, Yoshihara M, Imai K, Nomoto M, Moriyama Y, Yoshida S, Yamashita M, Kishigami Y, Oguchi H, Ushida T, Kajiyama H

    Scientific reports   Vol. 15 ( 1 ) page: 45510   2025.11

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    DOI: 10.1038/s41598-025-30028-y

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  58. Estimated fetal weight or gestational age: which is crucial for fetal cardiac evaluation?

    Tano S, Inamura T, Kato M, Ito M, Takeda T, Kinoshita F, Fuma K, Matsuo S, Ushida T, Imai K, Kajiyama H, Kotani T, Kishigami Y, Oguchi H

    Pediatric research     2025.11

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    DOI: 10.1038/s41390-025-04584-y

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  59. Exploring drug resistance via intercellular crosstalk using spatial transcriptomics in high-grade serous ovarian carcinoma.

    Suzuki H, Yoshida K, Yokoi A, Suzuki K, Hirano Y, Kitagawa M, Asano-Inami E, Yoshihara M, Nagao Y, Tamauchi S, Yoshikawa N, Kajiyama H, Yamamoto Y

    NPJ precision oncology   Vol. 9 ( 1 ) page: 345   2025.11

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    DOI: 10.1038/s41698-025-01122-1

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  60. Annual Report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2022 and Annual Treatment Report for 2017.

    Kajiyama H, Tamauchi S, Takahashi F, Satoh T, Board Members of the 2025 Committee on Gynecologic Oncology of the Japan Society of Obstetrics and Gynecology

    The journal of obstetrics and gynaecology research   Vol. 51 ( 11 ) page: e70124   2025.11

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    DOI: 10.1111/jog.70124

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  61. Recognizing an Incarcerated Gravid Uterus When the Cervical Canal Is Absent on Transvaginal Ultrasound.

    Okawa A, Tano S, Inoue M, Inamura T, Katsuki S, Fuma K, Matsuo S, Ushida T, Imai K, Kotani T, Kajiyama H

    Cureus   Vol. 17 ( 11 ) page: e97996   2025.11

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    DOI: 10.7759/cureus.97996

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  62. Application of multimodal integration to develop preoperative diagnostic models for borderline and malignant ovarian tumors.

    Kunishima A, Inaba D, Iyoshi S, Ikeda Y, Goto M, Muramatsu R, Hashimoto M, Yoshida K, Mogi K, Yoshihara M, Nagao Y, Tamauchi S, Yokoi A, Yoshikawa N, Niimi K, Koizumi N, Kajiyama H

    Scientific reports   Vol. 15 ( 1 ) page: 37114   2025.10

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    DOI: 10.1038/s41598-025-21128-w

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  63. Proteomic Profiling of Bacterial Extracellular Vesicles for Exploring Ovarian Cancer Biomarkers.

    Asano-Inami E, Yokoi A, Yoshida K, Taki K, Kitagawa M, Suzuki K, Uekusa R, Nagao Y, Yoshikawa N, Niimi K, Yamamoto Y, Kajiyama H

    Journal of extracellular biology   Vol. 4 ( 10 ) page: e70073   2025.10

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    DOI: 10.1002/jex2.70073

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  64. Ultrasound-guided insertion of controlled-release dinoprostone vaginal delivery system (PROPESS).

    Imai K, Tano S, Fuma K, Matsuo S, Ushida T, Kajiyama H, Kotani T

    Journal of medical ultrasonics (2001)   Vol. 52 ( 4 ) page: 443 - 444   2025.10

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    DOI: 10.1007/s10396-025-01552-1

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  65. Establishment of KGAS, a cell line derived from gastric-type adenocarcinoma of the uterine cervix.

    Yamada H, Yokoi A, Asano-Inami E, Kitagawa M, Yoshida K, Suzuki K, Nishio S, Kajiyama H, Tsuda N

    Human cell   Vol. 38 ( 6 ) page: 159   2025.9

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    DOI: 10.1007/s13577-025-01286-9

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  66. Bevacizumab in frontline chemotherapy improved the survival outcome for advanced ovarian clear cell carcinoma: a multicenter retrospective analysis.

    Tate S, Seki T, Nishikimi K, Unno Y, Itoi M, Ikeda S, Yoshikawa N, Akashi H, Suzuki E, Tanaka N, Hirakawa T, Kajiyama H, Takano H, Yoshihara K, Koga K, Okamoto A, Shozu M

    Journal of gynecologic oncology   Vol. 36 ( 5 ) page: e80   2025.9

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    DOI: 10.3802/jgo.2025.36.e80

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  67. Outcomes of cases with complete hydatidiform mole coexisting with a fetus: a single-center study.

    Niimi K, Shibata M, Yoshida K, Yamamoto E, Sumigama S, Yasui Y, Nishiko Y, Nishino K, Kajiyama H

    International journal of clinical oncology   Vol. 30 ( 9 ) page: 1866 - 1872   2025.9

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    DOI: 10.1007/s10147-025-02815-0

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  68. Quality indicators for endometrial cancer care in Japan.

    Kakuwa T, Ichinose Y, Rikitake R, Ishii T, Nagase S, Kobayashi Y, Kaneuchi M, Tokunaga H, Seino M, Kajiyama H, Takekuma M, Tabata T, Terai Y, Terao Y, Morisada T, Watari H, Yamamoto Y, Kawata A, Higashi T

    Journal of gynecologic oncology   Vol. 36 ( 5 ) page: e77   2025.9

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    DOI: 10.3802/jgo.2025.36.e77

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  69. Quantitative assessment of placental alpha macroglobulin-1 for predicting impending preterm delivery in asymptomatic women with a short cervix.

    Nozaki Y, Imai K, Miki R, Tano S, Fuma K, Matsuo S, Ushida T, Kajiyama H, Kotani T

    The journal of obstetrics and gynaecology research   Vol. 51 ( 9 ) page: e70071   2025.9

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    DOI: 10.1111/jog.70071

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  70. Vitamin D derivatives inhibit mesenchymal transition of mesothelial cells and mitigate peritoneal dissemination of ovarian cancer

    Fujita, K; Hayashi, M; Yoshihara, M; Nomura, S; Kitami, K; Miyamoto, E; Iyoshi, S; Mogi, K; Fujimoto, H; Uno, K; Kunishima, A; Yamakita, Y; Tomita, H; Tsutsumi, R; Sakamoto, R; Nagasawa, K; Masuo, Y; Nishiuchi, T; Shibata, K; Enomoto, A; Kajiyama, H

    MEDICAL MOLECULAR MORPHOLOGY   Vol. 58 ( 3 ) page: 171 - 182   2025.9

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  71. Overcoming platinum-resistant ovarian cancer targeting the activated JAK-STAT pathways via extracellular vesicles.

    Suzuki K, Yokoi A, Yoshida K, Suzuki H, Kitagawa M, Asano-Inami E, Matsuo S, Yoshihara M, Tamauchi S, Yoshikawa N, Niimi K, Sudo T, Yamaguchi S, Yamamoto Y, Kajiyama H

    Communications biology   Vol. 8 ( 1 ) page: 1305   2025.8

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    DOI: 10.1038/s42003-025-08771-9

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  72. Development and Validation of Predictive Risk Scores for Ovarian Clear Cell Carcinoma: A Penalized Regression Model.

    Iyoshi S, Emoto R, Yoshikawa N, Yoshida K, Yoshihara M, Tamauchi S, Yokoi A, Shimizu Y, Ikeda Y, Niimi K, Kawai M, Matsui S, Kajiyama H

    Cancer medicine   Vol. 14 ( 15 ) page: e71118   2025.8

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    DOI: 10.1002/cam4.71118

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  73. Neutrophil infiltration in peritoneal metastasis affects prognosis in patients with ovarian cancer.

    Miyamoto E, Yoshihara M, Iyoshi S, Mogi K, Uno K, Fujimoto H, Koya Y, Kitami K, Yoshida K, Tamauchi S, Yokoi A, Yoshikawa N, Niimi K, Tomita H, Kidoya H, Shiraki Y, Enomoto A, Kajiyama H

    Scientific reports   Vol. 15 ( 1 ) page: 23196   2025.7

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    DOI: 10.1038/s41598-025-05010-3

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  74. Antenatal corticosteroid treatment for women with hypertensive disorders of pregnancy: A population-based study in Japan.

    Ushida T, Fuma K, Katsuki S, Tano S, Matsuo S, Imai K, Kajiyama H, Kotani T

    The journal of obstetrics and gynaecology research   Vol. 51 ( 7 ) page: e16364   2025.7

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    DOI: 10.1111/jog.16364

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  75. Long-term prognostic significance of ascites cytology in ovarian cancer cases in which R0 resection was achieved in the initial surgery: a multi-institutional retrospective cohort study

    Iyoshi, S; Sunohara, M; Yoshihara, M; Kunishima, A; Miyamoto, E; Fujimoto, H; Kitami, K; Mogi, K; Uno, K; Yoshida, K; Tamauchi, S; Yokoi, A; Niimi, K; Yoshikawa, N; Emoto, R; Matsui, S; Kajiyama, H

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 55 ( 7 ) page: 743 - 750   2025.7

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  76. Tumor growth direction predicts surgical difficulty in large uterine fibroids: A retrospective imaging-based study.

    Tamauchi S, Niimi K, Iyoshi S, Yoshida K, Mogi K, Yoshihara M, Nagao Y, Yokoi A, Yoshikawa N, Kajiyama H

    The journal of obstetrics and gynaecology research   Vol. 51 ( 7 ) page: e70013   2025.7

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    DOI: 10.1111/jog.70013

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  77. Antitumor effects of plasma-activated sodium acetate solution on gastric cancer cells.

    Ito Y, Kanda M, Tanaka H, Nakamura K, Mizuno M, Hori M, Kajiyama H, Kodera Y

    Scientific reports   Vol. 15 ( 1 ) page: 19807   2025.6

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    DOI: 10.1038/s41598-025-04977-3

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  78. Glucose variability as a key mediator in the relationship between pre-pregnancy overweight/obesity and late-onset hypertensive disorders of pregnancy.

    Tano S, Kotani T, Inamura T, Kinoshita F, Fuma K, Matsuo S, Yoshihara M, Imai K, Yoshida S, Yamashita M, Kishigami Y, Oguchi H, Kajiyama H, Ushida T

    Scientific reports   Vol. 15 ( 1 ) page: 18123   2025.5

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    DOI: 10.1038/s41598-025-02965-1

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  79. Butyrate-producing bacteria in pregnancy maintenance: mitigating dysbiosis-induced preterm birth.

    Uchida A, Imai K, Miki R, Hamaguchi T, Nishiwaki H, Ito M, Ueyama J, Hattori S, Tano S, Fuma K, Matsuo S, Ushida T, Ohno K, Kajiyama H, Kotani T

    Journal of translational medicine   Vol. 23 ( 1 ) page: 533   2025.5

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    DOI: 10.1186/s12967-025-06534-y

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  80. Effect of chorioamnionitis on postnatal growth in very preterm infants: a population-based study in Japan

    Ushida, T; Nosaka, R; Nakatochi, M; Kobayashi, Y; Tano, S; Fuma, K; Matsuo, S; Imai, K; Sato, Y; Hayakawa, M; Kajiyama, H; Kotani, T

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 311 ( 5 ) page: 1321 - 1330   2025.5

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  81. Identification of Sphingosine Kinase 1 as a Novel Protein Regulated by High Molecular Weight Hyaluronan in Ovarian Cancer.

    Price ZK, Lokman NA, Morrison J, Mhlanga SN, Sugiyama M, Koya Y, Davies LT, Pitson SM, Oehler MK, Pitman MR, Yoshihara M, Kajiyama H, Ricciardelli C

    Journal of cellular and molecular medicine   Vol. 29 ( 9 ) page: e70574   2025.5

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    DOI: 10.1111/jcmm.70574

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  82. Japan Society of Gynecologic Oncology 2023 guidelines for treatment of uterine body neoplasm.

    Morisada T, Kobayashi Y, Nagase S, Baba T, Tokunaga H, Watari H, Takekuma M, Terao Y, Terai Y, Kajiyama H, Asai-Sato M, Takehara K, Tabata T, Harano K, Hirashima Y, Yunokawa M, Okamoto A, Mikami M

    Journal of gynecologic oncology   Vol. 36 ( 3 ) page: e119   2025.5

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    DOI: 10.3802/jgo.2025.36.e119

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  83. Single-Nucleus RNA Sequencing and Spatial Transcriptomics for Squamous Cell Carcinoma Arising From Ovarian Mature Teratoma

    Yoshida, K; Yokoi, A; Suzuki, H; Tamauchi, S; Kitagawa, M; Inami, E; Nakayama, J; Mori, Y; Okamoto, K; Suzuki, Y; Yoshida, H; Kato, T; Kajiyama, H; Yamamoto, Y

    CANCER SCIENCE   Vol. 116 ( 5 ) page: 1339 - 1351   2025.5

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  84. Dietary supplements and prevention of preeclampsia

    Ushida, T; Tano, S; Matsuo, S; Fuma, K; Imai, K; Kajiyama, H; Kotani, T

    HYPERTENSION RESEARCH   Vol. 48 ( 4 ) page: 1444 - 1457   2025.4

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  85. Selective Killing of Human Breast Cancer Cells by Plasma-Treated L-Arginine Solution

    Du, LY; Miron, C; Kondo, T; Kumagai, J; Mizuno, M; Toyokuni, S; Kajiyama, H; Hori, M; Tanaka, H

    PLASMA PROCESSES AND POLYMERS   Vol. 22 ( 4 )   2025.4

  86. Susceptibility of Brca1((L63X/+)) rat to ovarian reserve dissipation by chemotherapeutic agents to breast cancer.

    Kaseki S, Sonehara R, Motooka Y, Tanaka H, Nakamura T, Osuka S, Akatsuka S, Kajiyama H, Mashimo T, Imaoka T, Toyokuni S

    Cancer science   Vol. 116 ( 4 ) page: 1139 - 1152   2025.4

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    DOI: 10.1111/cas.16412

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  87. Survey of healthcare professionals' awareness of appearance care for Japanese cancer patients and their institutions' appearance care systems: report from the Japan Society of Clinical Oncology

    Kuji, S; Nozawa, K; Toma, S; Arao, H; Imoto, S; Kajiyama, H; Kitano, A; Kodera, Y; Saito, R; Sakai, R; Taketomi, A; Nakayama, R; Hiyama, E; Futamura, M; Matsui, M; Yonemura, M; Oya, M; Suzuki, N

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 30 ( 4 ) page: 655 - 665   2025.4

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  88. A novel senotherapeutic strategy with azithromycin for preventing endometriosis progression

    Sonehara, R; Nakamura, T; Takeda, T; Kaseki, S; Seki, T; Tanaka, H; Yabuki, A; Miyake, N; Muraoka, A; Osuka, S; Iwase, A; Kajiyama, H

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 23 ( 1 ) page: 47   2025.3

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  89. Editorial Expression of Concern: P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling

    Shibata, K; Kajiyama, H; Ino, K; Nawa, A; Nomura, S; Mizutani, S; Kikkawa, F

    BMC CANCER   Vol. 25 ( 1 ) page: 486   2025.3

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  90. Visualizing risk modification of hypertensive disorders of pregnancy: development and validation of prediction model for personalized interpregnancy weight management

    Tano, S; Kotani, T; Ushida, T; Matsuo, S; Yoshihara, M; Imai, K; Kinoshita, F; Moriyama, Y; Nomoto, M; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    HYPERTENSION RESEARCH   Vol. 48 ( 3 ) page: 884 - 893   2025.3

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  91. Advances in bacterial artificial chromosome (BAC) transgenic mice for gene analysis and disease research

    Mogi, K; Tomita, H; Yoshihara, M; Kajiyama, H; Hara, A

    GENE   Vol. 934   page: 149014   2025.1

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  92. Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders

    Fuma, K; Iitani, Y; Imai, K; Ushida, T; Tano, S; Yoshida, K; Yokoi, A; Miki, R; Kidokoro, H; Sato, Y; Hara, Y; Ogi, T; Nomaki, K; Tsuda, M; Komine, O; Yamanaka, K; Kajiyama, H; Kotani, T

    COMMUNICATIONS BIOLOGY   Vol. 8 ( 1 ) page: 75   2025.1

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  93. Serum-derived small extracellular vesicles as biomarkers for predicting pregnancy and delivery on assisted reproductive technology in patients with endometriosis

    Muraoka, A; Yokoi, A; Yoshida, K; Kitagawa, M; Murakami, M; Miyake, N; Sonehara, R; Nakamura, T; Osuka, S; Kajiyama, H

    FRONTIERS IN ENDOCRINOLOGY   Vol. 15   page: 1442684   2025.1

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  94. Effect of Cytokine Concentrations on Long-term Neurological Outcomes in Fetal Pleural Effusion Managed with Thoracoamniotic Shunt

    Imai, K; Tano, S; Fuma, K; Matsuo, S; Ushida, T; Kajiyama, H; Kotani, T

    JMA JOURNAL   Vol. 8 ( 1 ) page: 288 - 292   2025.1

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  95. Utility of manual vacuum aspiration followed by curettage in the treating hydatidiform mole: A retrospective analysis

    Aoki, U; Yoshida, K; Yasui, Y; Nishiko, Y; Yokoi, A; Yoshikawa, N; Nishino, K; Yamamoto, E; Niimi, K; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 51 ( 1 ) page: e16210   2025.1

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  96. Understanding the impact of spatial immunophenotypes on the survival of endometrial cancer patients through the ProMisE classification

    Hattori, S; Yoshikawa, N; Liu, WT; Matsukawa, T; Kubokawa, M; Yoshida, K; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yokoi, A; Shimizu, Y; Niimi, K; Kajiyama, H

    CANCER IMMUNOLOGY IMMUNOTHERAPY   Vol. 74 ( 2 ) page: 70   2025.1

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  97. Chemotherapeutic hormesis induced by the tumor microenvironment in refractory ovarian cancer

    Chang, XBY; Tamauchi, S; Nakagawa, A; Xinyuan, W; Yoshida, K; Yokoi, A; Yoshikawa, N; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 15 ( 1 ) page: 596   2025.1

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  98. 9-oxo-10,12-octadecadienoic acid suppresses the proliferation of human cervical cancer cells

    Mogi, K; Koya, Y; Yoshihara, M; Kunishima, A; Miyamoto, E; Fujimoto, H; Iyoshi, S; Uno, K; Kitami, K; Tamauchi, S; Yokoi, A; Niimi, K; Tomita, H; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 583 - 583   2025.1

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  99. Annual report of the committee on gynecologic oncology, the Japan Society of Obstetrics and Gynecology: Annual patient report for 2021 and annual treatment report for 2016

    Kajiyama, H; Tamauchi, S; Takahashi, F; Kawana, K

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 51 ( 1 ) page: e16168   2025.1

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  100. Discovery of ovarian high-grade endometrioid-type tumors through multi-omics analysis: JGOG3025-TR2 study

    Matsumura, N; Takamatsu, S; Hillman, TR; Yoshihara, K; Baba, T; Shimada, M; Yoshida, H; Kajiyama, H; Oda, K; Mandai, M; Okamoto, A; Enomoto, T

    CANCER SCIENCE   Vol. 116   page: 1898 - 1898   2025.1

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  101. Development of mesothelial cell-targeted therapy to overcome peritoneal dissemination of refractory ovarian cancer

    Yoshihara, M; Miyamoto, E; Mogi, K; Fujimoto, H; Iyoshi, S; Uno, K; Kunishima, A; Koya, Y; Kitami, K; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 1492 - 1492   2025.1

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  102. Development of an early diagnosis system for ovarian tumors using Artificial Intelligence

    Kunishima, A; Ikeda, Y; Inaba, D; Koizumi, N; Goto, M; Muramatsu, R; Hashimoto, M; Iyoshi, S; Yoshida, K; Mogi, K; Yoshihara, M; Tamauchi, S; Yokoi, A; Yoshikawa, N; Niimi, K; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 70 - 70   2025.1

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  103. Elucidation of a novel mechanism of ovarian cancer progression with tumor-associated fibrosis (TAF)

    Fujimoto, H; Yoshihara, M; Koya, Y; Miyamoto, E; Mogi, K; Uno, K; Iyoshi, S; Kitami, K; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 1493 - 1493   2025.1

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  104. Exploring the role of vitamin D derivatives in inhibiting peritoneal dissemination of ovarian cancer

    Hayashi, M; Yoshihara, M; Iyoshi, S; Mogi, K; Miyamoto, E; Fujimoto, H; Uno, K; Kitami, K; Nomura, S; Koya, Y; Hayakawa, S; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 1687 - 1687   2025.1

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  105. Meflin-positive cancer-associated fibroblasts exhibit anti-tumor effects in advanced ovarian cancer

    Miyamoto, E; Yoshihara, M; Koya, Y; Fujimoto, H; Iyoshi, S; Mogi, K; Uno, K; Kitami, K; Enomoto, A; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 1857 - 1857   2025.1

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  106. New applications of extracellular vesicle-associated DNAs for high-grade serous ovarian carcinoma

    Uekusa, R; Yokoi, A; Kitagawa, M; Yoshida, K; Matsuzaki, J; Yamamoto, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 1831 - 1831   2025.1

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  107. Metastatic units in ascites drive peritoneal dissemination and therapeutic resistance in advanced ovarian cancer

    Hayakawa, S; Yoshihara, M; Iyoshi, S; Mogi, K; Miyamoto, E; Fujimoto, H; Uno, K; Kitami, K; Nomura, S; Koya, Y; Hayashi, M; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 1859 - 1859   2025.1

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  108. Secretoglobin Superfamily Protein SCGB3A1 is a candidate tumor suppressor

    Yoneda, M; Yasui, K; Kajiyama, H; Kimura, S; Ikeda, H

    CANCER SCIENCE   Vol. 116   page: 904 - 904   2025.1

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  109. Unveiling complex glycomics in diverse extracellular vesicles in ovarian cancer

    Yokoi, A; Kitagawa, M; Kawahara, R; Thaysen, M; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 780 - 780   2025.1

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  110. Toward Overcoming Chemotherapy Hormesis Induced by the Microenvironment of Refractory Ovarian Cancer

    Tamauchi, S; Yoshida, K; Mogi, K; Iyoshi, S; Yoshihara, M; Yokoi, A; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 1686 - 1686   2025.1

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  111. The functional impact of intraperitoneal extracellular vesicle heterogeneity on ovarian cancer progression

    Hishikawa, R; Yokoi, A; Yoshida, K; Suzuki, K; Nagao, Y; Kitagawa, M; Yoshikawa, N; Niimi, K; Kitai, M; Yamaguchi, S; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 242 - 242   2025.1

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  112. Targeting JAK/STAT pathway via extracellular vesicles overcomes platinum resistance in ovarian cancer

    Suzuki, K; Yokoi, A; Yoshida, K; Kitagawa, M; Nagao, Y; Kitai, M; Sudo, T; Yamamoto, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 1291 - 1291   2025.1

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  113. Targeting adipocytes at tumor microenvironment of ovarian cancer omental metastasis

    Iyoshi, S; Taki, M; Aruba, R; Sato, A; Yoshihara, M; Koya, Y; Miyamoto, E; Fujimoto, H; Kunishima, A; Uno, K; Mogi, K; Kitami, K; Kajiyama, H

    CANCER SCIENCE   Vol. 116   page: 1494 - 1494   2025.1

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  114. Spatial transcriptomics and whole-exome sequencing to understand drug resistance mechanisms to PARP inhibitor in HGSOC

    Suzuki, H; Yoshida, K; Hirano, Y; Yokoi, A; Kajiyama, H; Yamamoto, Y

    CANCER SCIENCE   Vol. 116   page: 1860 - 1860   2025.1

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  115. Amelioration of polycystic ovarian morphology by Tokishakuyakusan in a PCOS rat model: association with bone morphogenetic protein 4.

    Ueda M, Osuka S, Yabuki A, Miyake N, Fujitsuka N, Nahata M, Tokita Y, Ruan J, Bayasula, Takeda T, Seki T, Sonehara R, Muraoka A, Nakamura T, Kajiyama H

    Frontiers in endocrinology   Vol. 16   page: 1649124   2025

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    DOI: 10.3389/fendo.2025.1649124

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  116. Extracellular vesicles display distinct glycosignatures in high-grade serous ovarian carcinoma

    Bienes, KM; Yokoi, A; Kitagawa, M; Kajiyama, H; Andersen, MT; Kawahara, R

    BBA ADVANCES   Vol. 7   page: 100140   2025

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  117. Patient awareness of long-term cardiovascular and metabolic disease risks after hypertensive disorders of pregnancy in Japan

    Ushida, T; Tano, S; Matsuo, S; Fuma, K; Imai, K; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 51 ( 1 ) page: e16183   2024.12

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  118. Assisted reproductive technology and prolonged third stage of labour: a multicentre study in Japan

    Kato, A; Ushida, T; Matsuo, S; Tano, S; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    REPRODUCTIVE BIOMEDICINE ONLINE   Vol. 49 ( 6 ) page: 104382   2024.12

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  119. Out-of-pocket fertility preservation expenses: data from a Japanese nationwide multicenter survey

    Ono, M; Takai, Y; Harada, M; Horie, A; Dai, YD; Kikuchi, E; Miyachi, M; Yamamoto, T; Fujii, N; Kajiyama, H; Manabe, A; Yasuoka, T; Katsuragi, S; Mekaru, K; Maezawa, T; Horage, Y; Kataoka, S; Nakayama, R; Nakajima, TE; Kimura, F; Shimizu, C; Sugimoto, K; Takae, S; Yumura, Y; Nishi, H; Furui, T; Morishige, KI; Watanabe, C; Osuga, Y; Suzuki, N

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 29 ( 12 ) page: 1959 - 1966   2024.12

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  120. Detailed analysis of the histology-specific impact of ascites volume on the outcome of epithelial ovarian cancer: a multi-institutional retrospective cohort study

    Iyoshi, S; Kimura, M; Yoshihara, M; Kunishima, A; Miyamoto, E; Fujimoto, H; Kitami, K; Mogi, K; Uno, K; Tano, S; Yoshikawa, N; Emoto, R; Matsui, S; Kajiyama, H

    BMC CANCER   Vol. 24 ( 1 ) page: 1479   2024.11

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  121. Circulating serum miRNAs predict response to platinum chemotherapy in high-grade serous ovarian cancer

    Suzuki, K; Yokoi, A; Matsuzaki, J; Yoshida, K; Yamamoto, Y; Kato, T; Ishikawa, M; Ochiya, T; Kajiyama, H

    CANCER MEDICINE   Vol. 13 ( 22 ) page: e70251   2024.11

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  122. Histology-specific long-term oncologic outcomes in patients with epithelial ovarian cancer who underwent complete tumor resection: The implication of occult seeds after initial surgery

    Mogi, K; Yoshihara, M; Emoto, R; Miyamoto, E; Fujimoto, H; Uno, K; Tano, S; Iyoshi, S; Kitami, K; Yoshikawa, N; Matsui, S; Kajiyama, H

    PLOS ONE   Vol. 19 ( 11 ) page: e0311421   2024.11

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  123. Association between anti-Müllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in Japan

    Miyake, N; Osuka, S; Ohsawa, I; Tonoike, T; Uno, T; Tsuzuki, K; Sonehara, R; Muraoka, A; Nakamura, T; Goto, M; Iwase, A; Kajiyama, H

    REPRODUCTIVE MEDICINE AND BIOLOGY   Vol. 23 ( 1 ) page: e12615   2024.11

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  124. Molecular classification of ovarian high-grade serous/endometrioid carcinomas through multi-omics analysis: JGOG3025-TR2 study

    Takamatsu, S; Hillman, RT; Yoshihara, K; Baba, T; Shimada, M; Yoshida, H; Kajiyama, H; Oda, K; Mandai, M; Okamoto, A; Enomoto, T; Matsumura, N

    BRITISH JOURNAL OF CANCER   Vol. 131 ( 8 ) page: 1340 - 1349   2024.11

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  125. Effects of autophagy on the selective death of human breast cancer cells exposed to plasma-activated Ringer's lactate solution

    Yamakawa, T; Tanaka, A; Miron, C; Nakamura, K; Kajiyama, H; Toyokuni, S; Mizuno, M; Hori, M; Tanaka, H

    FREE RADICAL RESEARCH   Vol. 58 ( 11 ) page: 758 - 769   2024.11

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  126. A randomized phase II study of secondary cytoreductive surgery in patients with relapsed ovarian cancer who have progressed on a PARP inhibitor as first-line maintenance therapy: the SOCCER-P study (KGOG 3067/JGOG 3036/APGOT-OV11)

    Cho, HW; Kim, HS; Park, JY; Lee, YY; Lim, MC; Lee, SJ; Min, KJ; Eoh, KJ; Lee, KB; Kim, MK; Song, JY; Shim, SH; Ji, YI; Song, YJ; Chang, SJ; Kim, MK; Abe, A; Kobayashi, Y; Kajiyama, H; Shimada, M; Okamoto, A; Ng, JS; Lee, JY

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 34 ( 11 ) page: 1809 - 1812   2024.11

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  127. Elevated levels of apolipoprotein A4 in umbilical cord serum from the maternal major depressive disorder

    Matsuo, S; Moriyama, Y; Ushida, T; Imai, K; Tano, S; Miki, R; Yoshida, K; Yokoi, A; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 11 ) page: 2038 - 2045   2024.11

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  128. Investigating the timing and site of recurrence for ovarian clear cell carcinoma: Analysis of the JGOG/GCIG trial-JGOG 3017-A3

    Yunokawa, M; Kurihara, N; Ishizuka, N; Kanao, H; Kajiyama, H; Shimada, M; Okamoto, A; Aoki, D; Sugiyama, T; Enomoto, T

    GYNECOLOGIC ONCOLOGY   Vol. 190   page: 113 - 118   2024.11

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  129. Impact of antenatal corticosteroids on subcortical volumes in preterm infants at term-equivalent age: A retrospective observational study

    Fuma, K; Ushida, T; Kawaguchi, M; Nosaka, R; Kidokoro, H; Tano, S; Imai, K; Sato, Y; Hayakawa, M; Kajiyama, H; Kotani, T

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 302   page: 7 - 14   2024.11

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  130. Identification of high-grade endometrioid-like serous carcinoma of the ovary through multi-omics analysis: JGOG-3025-TR2 study

    Takamatsu, S; Hillman, R; Yoshihara, K; Baba, T; Shimada, M; Yoshida, H; Kajiyama, H; Oda, K; Mandai, M; Okamoto, A; Enomoto, T; Matsumura, N

    GYNECOLOGIC ONCOLOGY   Vol. 190   page: S223 - S223   2024.11

  131. Elucidation of the role of XBP1 in the progression of complete hydatidiform mole to invasive mole through RNA-seq

    Shibata, M; Yoshida, K; Yokoi, A; Suzuki, H; Yamamoto, Y; Kitagawa, M; Asano-Inami, E; Yasui, Y; Nishiko, Y; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Nishino, K; Yamamoto, E; Niimi, K; Kajiyama, H

    GYNECOLOGIC ONCOLOGY   Vol. 190   page: 189 - 199   2024.11

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  132. Possible Efficacy of Vaginal Progesterone on Asymptomatic Women with a Short Cervix after 24 Weeks of Gestation: A Historical Cohort Study in Japan

    Otsuka, N; Imai, K; Tano, S; Matsuo, S; Ushida, T; Nomoto, M; Iitani, Y; Ishi, M; Kawai, Y; Furui, T; Kajiyama, H; Kotani, T

    JMA JOURNAL   Vol. 7 ( 4 ) page: 582 - 589   2024.10

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  133. Aging affects regrowth of stealthperitoneal dissemination of advanced ovarian cancer: a multicenter retrospective cohort study

    Fujimoto, H; Yoshihara, M; Ricciardelli, C; Tano, S; Iyoshi, S; Miyamoto, E; Mogi, K; Hayashi, M; Hayakawa, S; Nomura, S; Kitami, K; Uno, K; Yoshikawa, N; Emoto, R; Matsui, S; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 14 ( 1 ) page: 23537   2024.10

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  134. Celebrating <i>JOGR</i>'s 50th volume of publication

    Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50   page: 5 - 6   2024.10

  135. Fact-finding survey of gynecologic oncologist on appearance care for cancer patients in Japan

    Kuji, S; Nozawa, K; Toma, S; Arao, H; Imoto, S; Kajiyama, H; Kitano, A; Kodera, Y; Saito, R; Sakai, R; Taketomi, A; Nakayama, R; Hiyama, E; Futamura, M; Matsui, M; Yonemura, M; Oya, M; Suzuki, N

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 34 ( SUPPL_3 ) page: A328 - A328   2024.10

  136. Impact of antenatal corticosteroids-to-delivery interval on very preterm neonatal outcomes: a retrospective study in two tertiary centers in Japan

    Fuma, K; Kotani, T; Tsuda, H; Oshiro, M; Tano, S; Ushida, T; Imai, K; Sato, Y; Kajiyama, H

    BMC PREGNANCY AND CHILDBIRTH   Vol. 24 ( 1 ) page: 607   2024.9

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  137. Heterogeneous treatment effect of dose-dense paclitaxel plus carboplatin therapy for advanced ovarian cancer

    Taguchi, A; Kato, K; Furusawa, A; Hara, K; Sone, K; Yamada, K; Kajiyama, H; Shimada, M; Okamoto, A

    INTERNATIONAL JOURNAL OF CANCER   Vol. 155 ( 6 ) page: 1068 - 1077   2024.9

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  138. TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta

    Miki, R; Matsuo, S; Ushida, T; Tano, S; Imai, K; Nawa, A; Kajiyama, H; Kotani, T

    MOLECULAR AND CELLULAR ENDOCRINOLOGY   Vol. 591   page: 112277   2024.9

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  139. ESTABLISHMENT OF MTX-RESISTANT CELL LINES OF CHORIOCARCINOMA AND SEARCH FOR THERAPEUTIC AGENTS BY DRUG REPOSITIONING

    Nishiko, Y; Niimi, K; Yasui, Y; Yoshida, K; Nishino, K; Yamamoto, E; Kajiyama, H

    PLACENTA   Vol. 154   page: 234 - 235   2024.9

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  140. PATHOPHYSIOLOGY OF INCREASED VASCULAR PERMEABILITY MEDIATED BY PLACENTA-DERIVED EXTRACELLULAR VESICLES IN PREECLAMPSIA.

    Matsuo, S; Yokoi, A; Ushida, T; Yoshida, K; Kitagawa, M; Inami, E; Tano, S; Imai, K; Kajiyama, H; Kotani, T

    PLACENTA   Vol. 154   page: 226 - 226   2024.9

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  141. Educational results of the Japan Maternal Emergency Life-Saving (J-MELS) simulation training organized by Japan Council for the Implementation of the Maternal Emergency Life-Saving System (J-CIMELS): a 12-month longitudinal follow-up study in Japan

    Imai, K; Hashimoto, Y; Ito, Y; Sakata, K; Kawanami, M; Nakano-Kobayashi, T; Hashii, K; Yamahata, Y; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 9 ) page: 1513 - 1521   2024.9

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  142. Factors affecting the long-term prognosis of patients in the AYA generation with epithelial ovarian cancer: A multicenter propensity score matching analysis

    Miyamoto, E; Yoshihara, M; Iyoshi, S; Mogi, K; Uno, K; Fujimoto, H; Kitami, K; Yoshikawa, N; Kajiyama, H

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS   Vol. 166 ( 3 ) page: 1225 - 1231   2024.9

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  143. Tumor-associated fibrosis: a unique mechanism promoting ovarian cancer metastasis and peritoneal dissemination

    Fujimoto, H; Yoshihara, M; Rodgers, R; Iyoshi, S; Mogi, K; Miyamoto, E; Hayakawa, S; Hayashi, M; Nomura, S; Kitami, K; Uno, K; Sugiyama, M; Koya, Y; Yamakita, Y; Nawa, A; Enomoto, A; Ricciardelli, C; Kajiyama, H

    CANCER AND METASTASIS REVIEWS   Vol. 43 ( 3 ) page: 1037 - 1053   2024.9

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  144. Update on the oncologic and obstetric outcomes of medroxyprogesterone acetate treatment for atypical endometrial hyperplasia and endometrial cancer

    Tamauchi, S; Nakagawa, A; Yoshida, K; Yoshihara, M; Yokoi, A; Yoshikawa, N; Niimi, K; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 9 ) page: 1614 - 1621   2024.9

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  145. Risk factors for non-previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan

    Matsuo, S; Kotani, T; Tano, S; Ushida, T; Imai, K; Nakamura, T; Osuka, S; Goto, M; Osawa, M; Asada, Y; Kajiyama, H

    REPRODUCTIVE MEDICINE AND BIOLOGY   Vol. 23 ( 1 ) page: e12592   2024.7

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  146. Guideline for gynecological practice in Japan: Japan Society of Obstetrics and Gynecology and Japan Association of Obstetricians and Gynecologists 2023 edition

    Nishio, E; Ishitani, K; Arimoto, T; Igarashi, T; Ishikawa, T; Iwase, A; Ogawa, M; Ozawa, N; Kajiyama, H; Kawasaki, K; Kudo, R; Kumakiri, J; Komura, H; Komai, K; Sato, S; Shinohara, K; Takahashi, T; Tanaka, K; Tanebe, K; Deguchi, M; Tozawa-Ono, A; Nakashima, A; Nakatsuka, M; Hayakawa, S; Hirata, T; Fukuhara, R; Miyakuni, Y; Miyazaki, H; Morisada, T; Kuwabara, Y; Takenaka, M; Shozu, M; Sugiura-Ogasawara, M; Maeda, T; Yokoyama, Y; Fujii, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 7 ) page: 1073 - 1094   2024.7

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  147. Identifying the high-benefit population for weight management-based cardiovascular disease prevention in Japan

    Tano, S; Kotani, T; Matsuo, S; Ushida, T; Imai, K; Kajiyama, H

    PREVENTIVE MEDICINE REPORTS   Vol. 43   page: 102782   2024.7

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  148. Spatial distribution of tumor-resident macrophages as predictive biomarkers in endometrial cancer

    Matsukawa, T; Yoshikawa, N; Liu, WT; Hattori, S; Yoshida, K; Yoshihara, M; Tamauchi, S; Yokoi, A; Niimi, K; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 7 ) page: 1141 - 1147   2024.7

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  149. The Fate of Angiotensin II in Placental Tissue and Blood

    Mizutani, S; Mizutani, H; Mizutani, E; Arita, H; Kajiyama, H

    HORMONE AND METABOLIC RESEARCH   Vol. 56 ( 07 ) page: 477 - 481   2024.7

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  150. Amniotic fluid-derived small extracellular vesicles for predicting postnatal severe outcome of congenital diaphragmatic hernia

    Matsuo, S; Yokoi, A; Yoshida, K; Kitagawa, M; Asano-Inami, E; Miura, M; Yasui, T; Tano, S; Ushida, T; Imai, K; Kajiyama, H; Kotani, T

    JOURNAL OF EXTRACELLULAR BIOLOGY   Vol. 3 ( 6 ) page: e160   2024.6

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  151. Discrimination of extracellular miRNA sources for the identification of tumor-related functions based on nanowire thermofluidics

    Chattrairat, K; Yokoi, A; Zhang, M; Iida, M; Yoshida, K; Kitagawa, M; Niwa, A; Maeki, M; Hasegawa, T; Yokoyama, T; Tanaka, Y; Miyazaki, Y; Shinoda, W; Tokeshi, M; Nagashima, K; Yanagida, T; Kajiyama, H; Baba, Y; Yasui, T

    DEVICE   Vol. 2 ( 6 )   2024.6

  152. Safety assessments and clinical features of PARP inhibitors from real-world data of Japanese patients with ovarian cancer

    Uekusa, R; Yokoi, A; Watanabe, E; Yoshida, K; Yoshihara, M; Tamauchi, S; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Niimi, K; Suzuki, S; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 14 ( 1 ) page: 12595   2024.6

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  153. Long noncoding RNA <i>TUG1</i> promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta

    Sonobe, R; Yang, P; Suzuki, MM; Shinjo, K; Iijima, K; Nishiyama, N; Miyata, K; Kataoka, K; Kajiyama, H; Kondo, Y

    CANCER SCIENCE   Vol. 115 ( 6 ) page: 1910 - 1923   2024.6

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  154. Postpartum and interpregnancy care of women with a history of hypertensive disorders of pregnancy

    Ushida, T; Tano, S; Imai, K; Matsuo, S; Kajiyama, H; Kotani, T

    HYPERTENSION RESEARCH   Vol. 47 ( 6 ) page: 1457 - 1469   2024.6

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  155. Plasma Exchange in Postpartum Hemorrhage (PPH)-Associated Thrombotic Microangiopathy (TMA): A Case Report

    Okawa, A; Yoshihara, M; Osafune, A; Umez, T; Kajiyama, H

    CUREUS JOURNAL OF MEDICAL SCIENCE   Vol. 16 ( 5 ) page: e59623   2024.5

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  156. A case of complete remission of intractable gestational choriocarcinoma with subsequent chemotherapy after pembrolizumab (vol 62, pg 745, 2023)

    Niimi, K; Yamamoto, E; Oda, Y; Nishiko, Y; Shibata, M; Nishino, K; Kajiyama, H

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   Vol. 63 ( 3 ) page: 442 - 442   2024.5

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  157. Current treatment strategies for ovarian cancer in the East Asian Gynecologic Oncology Trial Group (EAGOT)

    Kobayashi, Y; Shimada, M; Tamate, M; Cho, HW; Zhu, J; Chou, HH; Kajiyama, H; Okamoto, A; Aoki, D; Kang, S; Lee, JW; Kim, JW; Kim, JH; Lin, ZQ; Liu, JH; Wu, XH; Lai, HC; Chang, TC; Lai, CH; Kim, YM; Enomoto, T

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 35 ( 3 ) page: e87   2024.5

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  158. Importance of the time sequence between measurement of the predictor and of the predicted outcome: Response

    Mizutani, H; Ushida, T; Kajiyama, H; Kotani, T

    INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA   Vol. 58   page: 103995   2024.5

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  159. Intrauterine exposure to chorioamnionitis and neuroanatomical alterations at term-equivalent age in preterm infants

    Nosaka, R; Ushida, T; Kidokoro, H; Kawaguchi, M; Shiraki, A; Iitani, Y; Imai, K; Nakamura, N; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 309 ( 5 ) page: 1909 - 1918   2024.5

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  160. Practical weight management to minimize pregnancy complications and promote women's health: the possibility of interpregnancy care

    Kotani, T; Tano, S; Ushida, T; Imai, K; Kajiyama, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 86 ( 2 ) page: 160 - 168   2024.5

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  161. Predictive performance of Shock Index for postpartum hemorrhage during cesarean delivery

    Mizutani, H; Ushida, T; Ozeki, K; Tano, S; Iitani, Y; Imai, K; Nishiwaki, K; Kajiyama, H; Kotani, T

    INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA   Vol. 58   page: 103957   2024.5

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  162. Real-world data of poly (ADP-ribose) polymerase inhibitor response in Japanese patients with ovarian cancer

    Uekusa, R; Yokoi, A; Watanabe, E; Yoshida, K; Yoshihara, M; Tamauchi, S; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Niimi, K; Suzuki, S; Kajiyama, H

    CANCER MEDICINE   Vol. 13 ( 7 ) page: e7149   2024.4

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  163. Predicting preterm birth within 2 weeks in asymptomatic women with a short cervix: Combined effects of cervicovaginal fluid cytokine levels and fetal fibronectin test

    Ohori, Y; Imai, K; Tano, S; Owaki, T; Miki, R; Nozaki, Y; Ushida, T; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 4 ) page: 587 - 595   2024.4

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  164. Usefulness of fluorescent ureteral navigation in total pelvic exenteration using a two-team approach for locally recurrent pelvic malignancies-A video vignette

    Ogura, A; Murata, Y; Jinno, T; Yoshikawa, N; Kajiyama, H; Ebata, T

    COLORECTAL DISEASE   Vol. 26 ( 4 ) page: 812 - 813   2024.4

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  165. Uterine leiomyosarcoma cell-derived extracellular vesicles induce the formation of cancer-associated fibroblasts

    Nagao, Y; Yokoi, A; Yoshida, K; Kitagawa, M; Asano-Inami, E; Kato, T; Ishikawa, M; Yamamoto, Y; Kajiyama, H

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE   Vol. 1870 ( 4 ) page: 167103   2024.4

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  166. A Novel Stromal-Targeted Therapeutic Strategy for Refractory Ovarian Cancer Based on the Intraperitoneal Ecosystem

    Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 1652 - 1652   2024.3

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  167. Application of DNA in Extracellular Vesicles to Predict PARP inhibitor Response in High Grade Serous Ovarian Carcinoma

    Uekusa, R; Yokoi, A; Kitagawa, M; Yoshida, K; Matsuzaki, J; Yamamoto, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 2145 - 2145   2024.3

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  168. CRISPR-Cas9 in vivo screening for novel therapy for malignant transformation of mature cystic teratoma of the ovary

    Tamauchi, S; Chang, XY; Yoshida, K; Yokoi, A; Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 1237 - 1237   2024.3

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  169. Cancer-associated mesothelial cells that phagocytize apoptotic ovarian cancer cells may suppress anti-cancer immunity

    Koya, Y; Kitami, K; Yoshihara, M; Sugiyama, M; Uno, K; Mogi, K; Iyoshi, S; Fujimoto, H; Miyamoto, E; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 1402 - 1402   2024.3

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  170. CAMs as a source of intratumoral vessels are potential therapeutic targets for ovarian cancer

    Mogi, K; Taniguchi, T; Yoshihara, M; Miyamoto, E; Fujimoto, H; Iyoshi, S; Uno, K; Kitami, K; Sugiyama, M; Koya, Y; Tomita, H; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 1179 - 1179   2024.3

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  171. BRCA2 germline mutation promotes follicle development and induces diminished ovarian reserve

    Tanaka, H; Motooka, Y; Maeda, Y; Mashimo, T; Kajiyama, H; Toyokuni, S

    CANCER SCIENCE   Vol. 115   page: 172 - 172   2024.3

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  172. Effect of aging and PARP inhibitor, olaparib on ovarian function with <i>BRCA1</i> mutant model rats

    Sonehara, R; Motooka, Y; Mashimo, T; Imaoka, T; Kajiyama, H; Toyokuni, S

    CANCER SCIENCE   Vol. 115   page: 170 - 170   2024.3

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  173. Internet survey on HPV vaccination for men

    Yagi, A; Ueda, Y; Kimura, T; Kitano, A; Shimizu, C; Yoshihara, M; Shimizu, Y; Takae, S; Harada, M; Furui, T; Morishige, K; Kajiyama, H; Suzuki, N

    CANCER SCIENCE   Vol. 115   page: 127 - 127   2024.3

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  174. Identifying high-grade serous ovarian carcinoma-specific membrane proteins on small extracellular vesicles

    Yokoi, A; Ukai, M; Yasui, T; Kitagawa, M; Yoshida, K; Inami, E; Ishikawa, M; Kato, T; Matsuzaki, J; Yamamoto, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 789 - 789   2024.3

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  175. Exploring mean platelet volume as a survival indicator in ovarian clear cell carcinoma: a retrospective analysis and random forest model assessment

    Yoshikawa, N; Kubokawa, M; Matsukawa, T; Kajiyama, H

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 34 ( SUPPL_1 ) page: A312 - A312   2024.3

  176. Elucidation of mechanisms underlying malignant transformation of ovarian mature teratoma through spatial transcriptomics

    Yoshida, K; Yokoi, A; Chang, XBY; Tamauchi, S; Kitagawa, M; Inami, E; Nakayama, J; Kato, T; Yamamoto, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 1235 - 1235   2024.3

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  177. Elaborate cooperation of poly(rC)-binding proteins 1/2 and glutathione in ferroptosis induced by plasma-activated Ringer's lactate

    Jiang, L; Zheng, H; Ishida, M; Lyu, Q; Akatsuka, S; Motooka, Y; Sato, K; Sekido, Y; Nakamura, K; Tanaka, H; Ishikawa, K; Kajiyama, H; Mizuno, M; Hori, M; Toyokuni, S

    FREE RADICAL BIOLOGY AND MEDICINE   Vol. 214   page: 28 - 41   2024.3

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  178. Large scale proteomics of malignant ascites in ovarian cancer reveals distinct subgroups and prognostic biomarkers

    Iyoshi, S; Dreyer, T; Yoshihara, M; Yamakita, Y; Magdolen, V; Kajiyama, H; Schilling, O

    CANCER SCIENCE   Vol. 115   page: 439 - 439   2024.3

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  179. Overcoming platinum resistance of ovarian cancer regulating the activated JAK/STAT pathways via extracellular vesicles

    Suzuki, K; Yokoi, A; Yoshida, K; Inami, E; Kitagawa, M; Yamamoto, Y; Kitai, M; Ueno, S; Sudo, T; Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 129 - 129   2024.3

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  180. Novel therapeutic strategies targeting UCP2 in uterine leiomyosarcoma

    Nagao, Y; Yokoi, A; Yoshida, K; Sugiyama, M; Watanabe, E; Kitagawa, M; Yoshihara, M; Tamauchi, S; Kato, T; Ishikawa, M; Yamamoto, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 1232 - 1232   2024.3

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  181. NGFR contributes progression of ovarian cancer through promoting proliferation and invasion.

    Miyamoto, E; Koya, Y; Yoshihara, M; Sugiyama, M; Iyoshi, S; Kitami, K; Uno, K; Mogi, K; Fujimoto, H; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 1700 - 1700   2024.3

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  182. Serum miRNA as a predictive biomarker for ovarian reserve after endometrioma-cystectomy

    Yabuki, A; Muraoka, A; Osuka, S; Yokoi, A; Yoshida, K; Kitagawa, M; Bayasura; Sonehara, R; Miyake, N; Nakanishi, N; Nakamura, T; Iwase, A; Kajiyama, H

    REPRODUCTIVE BIOLOGY   Vol. 24 ( 1 ) page: 100821   2024.3

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  183. Therapeutic potential of extracellular vesicles from adipose-derived stem cells in ovarian cancer

    Suzuki, H; Yokoi, A; Uno, K; Yoshida, K; Inami, E; Kitagawa, M; Suzuki, K; Nagao, Y; Yamamoto, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 1011 - 1011   2024.3

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  184. The character of tumor-associated fibrosis in peritoneal dissemination of advanced ovarian cancer

    Yoshihara, M; Miyamoto, E; Iyoshi, S; Mogi, K; Fujimoto, H; Sugiyama, M; Kitami, K; Koya, Y; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 115   page: 1165 - 1165   2024.3

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  185. Small extracellular vesicles in follicular fluids for predicting reproductive outcomes in assisted reproductive technology

    Muraoka, A; Yokoi, A; Yoshida, K; Kitagawa, M; Asano-Inami, E; Murakami, M; Bayasula; Miyake, N; Nakanishi, N; Nakamura, T; Osuka, S; Iwase, A; Kajiyama, H

    COMMUNICATIONS MEDICINE   Vol. 4 ( 1 ) page: 33   2024.2

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  186. <i>Brca2<SUP>(p.T1942fs/+)</SUP></i> dissipates ovarian reserve in rats through oxidative stress in follicular granulosa cells

    Tanaka, H; Motooka, Y; Maeda, Y; Sonehara, R; Nakamura, T; Kajiyama, H; Mashimo, T; Toyokuni, S

    FREE RADICAL RESEARCH   Vol. 58 ( 2 ) page: 130 - 143   2024.2

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  187. An update of oncologic and obstetric outcomes of radical trachelectomy for early-stage cervical cancer: The need for further minimally invasive treatment

    Tamauchi, S; Iyoshi, S; Yoshihara, M; Yoshida, K; Ikeda, Y; Shimizu, Y; Yokoi, A; Niimi, K; Yoshikawa, N; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 2 ) page: 175 - 181   2024.2

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  188. Chondroitin Sulfate Proteoglycan 4 Provides New Treatment Approach to Preventing Peritoneal Dissemination in Ovarian Cancer

    Uno, K; Koya, Y; Yoshihara, M; Iyoshi, S; Kitami, K; Sugiyama, M; Miyamoto, E; Mogi, K; Fujimoto, H; Yamakita, Y; Wang, XH; Nawa, A; Kajiyama, H

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 25 ( 3 )   2024.2

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  189. Effect of radical trachelectomy on ovarian reserve: A single-institute prospective study

    Nakagawa, A; Tamauchi, S; Sato, M; Yoshihara, M; Yokoi, A; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Niimi, K; Osuka, S; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 2 ) page: 212 - 217   2024.2

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  190. The influence of radical trachelectomy on endometrial thickness in in vitro fertilization-embryo transfer

    Yabuki, A; Muraoka, A; Tamauchi, S; Seki, T; Takeda, T; Sonehara, R; Miyake, N; Nakamura, T; Osuka, S; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 50 ( 2 ) page: 218 - 224   2024.2

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  191. Emerging bacterial factors for understanding pathogenesis of endometriosis

    Muraoka, A; Yokoi, A; Kajiyama, H

    ISCIENCE   Vol. 27 ( 1 ) page: 108739   2024.1

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  192. Interleukin-17A stimulation induces alterations in Microglial microRNA expression profiles

    Iitani, Y; Miki, R; Imai, K; Fuma, K; Ushida, T; Tano, S; Yoshida, K; Yokoi, A; Kajiyama, H; Kotani, T

    PEDIATRIC RESEARCH   Vol. 95 ( 1 ) page: 167 - 173   2024.1

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  193. Cold Atmospheric Pressure Plasma-Activated Liquids for Cancer Treatment

    Miron, C; Hiromasa, T; Britun, N; Hashizume, H; Ishikawa, K; Du, LY; Yamakawa, T; Kurebayashi, Y; Kondo, T; Kondo, H; Kajiyama, H; Toyokuni, S; Mizuno, M; Hori, M

    ADVANCES IN DIGITAL HEALTH AND MEDICAL BIOENGINEERING, VOL 3, EHB-2023   Vol. 111   page: 150 - 162   2024

  194. Proposal for Classifying the Emetogenicity of Oral Anticancer Agents with a Focus on PARP Inhibitors: A Prospective, Observational, Multicenter Study (JASCC-CINV 2002)

    Yamamoto, S; Tsuchiya, M; Iihara, H; Hayasaki, Y; Hori, K; Kumakura, Y; Watanabe, D; Sakai, H; Nakagawa, S; Kudoh, A; Oishi, H; Kado, N; Go, M; Mashima, K; Uchida, T; Yasue, M; Maeda, A; Nishino, K; Matsumoto, K; Sato, S; Ueda, Y; Tomio, K; Hayashi, K; Takenaka, M; Mori, M; Kajiyama, H; Bomoto, Y; Suzuki, S; Ishihara, T; Suzuki, A; Abe, M

    JOURNAL OF CANCER   Vol. 15 ( 6 ) page: 1487 - 1497   2024

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  195. Antenatal prediction models for outcomes of extremely and very preterm infants based on machine learning

    Ushida, T; Kotani, T; Baba, J; Imai, K; Moriyama, Y; Nakano-Kobayashi, T; Iitani, Y; Nakamura, N; Hayakawa, M; Kajiyama, H

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 308 ( 6 ) page: 1755 - 1763   2023.12

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  196. Mean platelet volume as a potential biomarker for survival outcomes in ovarian clear cell carcinoma

    Yoshikawa, N; Matsukawa, T; Hattori, S; Iyoshi, S; Yoshida, K; Yoshihara, M; Tamauchi, S; Shimizu, Y; Ikeda, Y; Yokoi, A; Niimi, K; Kawai, M; Kajiyama, H

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 28 ( 12 ) page: 1680 - 1689   2023.12

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  197. New-onset postpartum hypertension in women without a history of hypertensive disorders of pregnancy: a multicenter study in Japan

    Ushida, T; Nakamura, N; Katsuki, S; Mizutani, H; Iitani, Y; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    HYPERTENSION RESEARCH   Vol. 46 ( 12 ) page: 2583 - 2592   2023.12

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  198. Sex-specific differences in head circumference of term singletons after assisted reproductive technology: a multicentre study in Japan

    Matsuo, S; Ushida, T; Tano, S; Imai, K; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    REPRODUCTIVE BIOMEDICINE ONLINE   Vol. 47 ( 6 ) page: 103331   2023.12

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  199. Establishment and characterization of a non-gestational choriocarcinoma patient-derived xenograft model

    Oda, Y; Niimi, K; Yoshida, K; Tamauchi, S; Yokoi, A; Yasui, Y; Nishiko, Y; Shibata, M; Shimizu, Y; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Yamamoto, E; Kajiyama, H

    BMC CANCER   Vol. 23 ( 1 ) page: 1103   2023.11

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  200. Spatial exosome analysis using cellulose nanofiber sheets reveals the location heterogeneity of extracellular vesicles

    Yokoi, A; Yoshida, K; Koga, H; Kitagawa, M; Nagao, Y; Iida, M; Kawaguchi, S; Zhang, M; Nakayama, J; Yamamoto, Y; Baba, Y; Kajiyama, H; Yasui, T

    NATURE COMMUNICATIONS   Vol. 14 ( 1 ) page: 6915   2023.11

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  201. 9-oxo-ODAs suppresses the proliferation of human cervical cancer cells through the inhibition of CDKs and HPV oncoproteins

    Mogi, K; Koya, Y; Yoshihara, M; Sugiyama, M; Miki, R; Miyamoto, E; Fujimoto, H; Kitami, K; Iyoshi, S; Tano, S; Uno, K; Tamauchi, S; Yokoi, A; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Niimi, K; Yamakita, Y; Tomita, H; Shibata, K; Nawa, A; Tomoda, Y; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 19208   2023.11

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  202. Small Extracellular Vesicles from adipose-derived stem cells suppress cell proliferation by delivering the let-7 family of microRNAs in ovarian cancer

    Suzuki, H; Yokoi, A; Uno, K; Yoshida, K; Kitagawa, M; Asano-Inami, E; Matsuo, S; Nagao, Y; Suzuki, K; Nakamura, K; Yoshihara, M; Tamauchi, S; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Kajiyama, H; Yamamoto, Y

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 680   page: 211 - 219   2023.11

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  203. Antenatal corticosteroids and outcomes of small for gestational age infants born at 24-31 gestational weeks: a population-based propensity score matching analysis

    Ushida, T; Nakatochi, M; Kobayashi, Y; Nakamura, N; Fuma, K; Iitani, Y; Imai, K; Sato, Y; Hayakawa, M; Kajiyama, H; Kotani, T; Japan, NRNO

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 308 ( 5 ) page: 1463 - 1471   2023.11

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  204. Disabled-2: a protein up-regulated by high molecular weight hyaluronan has both tumor promoting and tumor suppressor roles in ovarian cancer

    Price, ZK; Lokman, NA; Sugiyama, M; Koya, Y; Yoshihara, M; Oehler, MK; Kajiyama, H; Ricciardelli, C

    CELLULAR AND MOLECULAR LIFE SCIENCES   Vol. 80 ( 11 ) page: 320   2023.11

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  205. CD47 expression and macrophage infiltration in type 2 endometrial cancer

    Matsukawa, T; Yoshikawa, N; Kubokawa, M; Liu, WT; Kajiyama, H

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 33 ( SUPPL_4 ) page: A138 - A138   2023.11

  206. Ovarian cancer: Novel mechanisms and therapeutic targets regarding the microenvironment in the abdominal cavity

    Yoshihara, M; Iyoshi, S; Mogi, K; Uno, K; Fujimoto, H; Miyamoto, E; Nomura, S; Kitami, K; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 11 ) page: 2620 - 2628   2023.11

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  207. The prognostic impact of limited-staging surgery in patients with stage ia epithelial ovarian cancer: a multi-center study with a propensity score-adjusted analysis

    Miyamoto, E; Suzuki, H; Yoshihara, M; Iyoshi, S; Mogi, K; Uno, K; Fujimoto, H; Kitami, K; Tano, S; Kajiyama, H

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 33 ( SUPPL_4 ) page: A196 - A196   2023.11

  208. The role of DDIT4 as a hypoxia-inducible gene and prognostic biomarker in type II endometrial cancer

    Yoshikawa, N; Matsukawa, T; Kubokawa, M; Liu, WT; Kajiyama, H

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 33 ( SUPPL_4 ) page: A137 - A138   2023.11

  209. An Attempt to Develop a New Treatment Strategy for Rare Refractory Gynecological Malignancies: The Japanese Gynecologic Oncology Group

    Shigeta, S; Shimada, M; Suzuki, S; Kajiyama, H; Oda, K; Takehara, K; Mandai, M; Aoki, D; Enomoto, T; Okamoto, A

    JMA JOURNAL   Vol. 6 ( 4 ) page: 527 - 531   2023.10

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  210. The sarcopenia index measured using the lumbar paraspinal muscle is associated with prognosis in endometrial cancer

    Uno, K; Yoshikawa, N; Kitami, K; Mori, S; Shibata, T; Iyoshi, S; Fujimoto, H; Mogi, K; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yokoi, A; Kato, K; Hoshiba, T; Oguchi, H; Kajiyama, H

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 53 ( 10 ) page: 942 - 949   2023.10

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  211. Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with DNA mismatch repair deficient (dMMR) tumors, third edition

    Mishima, S; Naito, Y; Akagi, K; Hayashi, N; Hirasawa, A; Hishiki, T; Igarashi, A; Ikeda, M; Kadowaki, S; Kajiyama, H; Kato, M; Kenmotsu, H; Kodera, Y; Komine, K; Koyama, T; Maeda, O; Miyachi, M; Nishihara, H; Nishiyama, H; Ohga, S; Okamoto, W; Oki, E; Ono, S; Sanada, M; Sekine, I; Takano, T; Tao, KYK; Terashima, K; Tsuchihara, K; Yatabe, Y; Yoshino, T; Baba, E

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 28 ( 10 ) page: 1237 - 1258   2023.10

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  212. Unkeito promotes follicle development by restoring reduced follicle-stimulating hormone responsiveness in rats with polycystic ovary syndrome

    Yoshita, S; Osuka, S; Shimizu, T; Fujitsuka, N; Matsumoto, C; Bayasula; Miyake, N; Muraoka, A; Nakanishi, N; Nakamura, T; Goto, M; Kajiyama, H

    FRONTIERS IN ENDOCRINOLOGY   Vol. 14   page: 1228088   2023.9

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  213. Unclear tumor border in magnetic resonance imaging as a prognostic factor of squamous cell cervical cancer

    Sato, M; Tamauchi, S; Yoshida, K; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 15392   2023.9

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  214. A case of complete remission of intractable gestational choriocarcinoma with subsequent chemotherapy after pembrolizumab

    Niimi, K; Yamamoto, E; Oda, Y; Nishiko, Y; Shibata, M; Nishino, K; Kajiyama, H

    TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY   Vol. 62 ( 5 ) page: 745 - 748   2023.9

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  215. Comparison of the efficacy between controlled-release dinoprostone delivery system (PROPESS) and Cook's double balloon catheter plus oxytocin: A retrospective single-center study in Japan

    Imai, K; Nozaki, Y; Ushida, T; Tano, S; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 9 ) page: 2317 - 2323   2023.9

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  216. DDIT4 Facilitates Lymph Node Metastasis via the Activation of NF-kB Pathway and Epithelial-Mesenchymal Transition

    Lin, XX; Yoshikawa, N; Liu, WT; Matsukawa, T; Nakamura, K; Yoshihara, M; Koya, Y; Sugiyama, M; Tamauchi, S; Ikeda, Y; Yokoi, A; Shimizu, Y; Kajiyama, H

    REPRODUCTIVE SCIENCES   Vol. 30 ( 9 ) page: 2829 - 2841   2023.9

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  217. The balance between fetal oxytocin and placental leucine aminopeptidase (P-LAP) controls human uterine contraction around labor onset

    Yoshihara, M; Mizutani, S; Matsumoto, K; Kato, Y; Masuo, Y; Harumasa, A; Iyoshi, S; Tano, S; Mizutani, H; Kotani, T; Mizutani, E; Shibata, K; Kajiyama, H

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X   Vol. 19   page: 100210   2023.9

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  218. Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with high tumor mutational burden tumors

    Mishima, S; Naito, Y; Akagi, K; Hayashi, N; Hirasawa, A; Hishiki, T; Igarashi, A; Ikeda, M; Kadowaki, S; Kajiyama, H; Kato, M; Kenmotsu, H; Kodera, Y; Komine, K; Koyama, T; Maeda, O; Miyachi, M; Nishihara, H; Nishiyama, H; Ohga, S; Okamoto, W; Oki, E; Ono, S; Sanada, M; Sekine, I; Takano, T; Tao, KYK; Terashima, K; Tsuchihara, K; Yatabe, Y; Yoshino, T; Baba, E

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 28 ( 8 ) page: 941 - 955   2023.8

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  219. Local hyperthermia with built-in endoscopy for radioresistant cervical cancer: a case series

    Yoshikawa, N; Itoh, Y; Matsukawa, T; Kawamura, M; Yamada, K; Nakamura, S; Kajiyama, H

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 3 ) page: 639 - 647   2023.8

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  220. The prognostic impact of limited-staging surgery in patients with stage IA epithelial ovarian cancer: a multi-center study with a propensity score-adjusted analysis

    Miyamoto, E; Suzuki, H; Yoshihara, M; Mogi, K; Iyoshi, S; Uno, K; Fujimoto, H; Kitami, K; Tano, S; Emoto, R; Matsui, S; Kajiyama, H

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 53 ( 8 ) page: 698 - 703   2023.8

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  221. Altered offspring neurodevelopment in an L-NAME-induced preeclampsia rat model

    Nakamura, N; Ushida, T; Onoda, A; Ueda, K; Miura, R; Suzuki, T; Katsuki, S; Mizutani, H; Yoshida, K; Tano, S; Iitani, Y; Imai, K; Hayakawa, M; Kajiyama, H; Sato, Y; Kotani, T

    FRONTIERS IN PEDIATRICS   Vol. 11   page: 1168173   2023.7

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  222. Identifying high-grade serous ovarian carcinoma-specific extracellular vesicles by polyketone-coated nanowires

    Yokoi, A; Ukai, M; Yasui, T; Inokuma, Y; Hyeon-Deuk, K; Matsuzaki, J; Yoshida, K; Kitagawa, M; Chattrairat, K; Iida, M; Shimada, T; Manabe, Y; Chang, IY; Asano-Inami, E; Koya, Y; Nawa, A; Nakamura, K; Kiyono, T; Kato, T; Hirakawa, A; Yoshioka, Y; Ochiya, T; Hasegawa, T; Baba, Y; Yamamoto, Y; Kajiyama, H

    SCIENCE ADVANCES   Vol. 9 ( 27 ) page: eade6958   2023.7

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  223. Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors

    Naito, Y; Mishima, S; Akagi, K; Hayashi, N; Hirasawa, A; Hishiki, T; Igarashi, A; Ikeda, M; Kadowaki, S; Kajiyama, H; Kato, M; Kenmotsu, H; Kodera, Y; Komine, K; Koyama, T; Maeda, O; Miyachi, M; Nishihara, H; Nishiyama, H; Ohga, S; Okamoto, W; Oki, E; Ono, S; Sanada, M; Sekine, I; Takano, T; Tao, K; Terashima, K; Tsuchihara, K; Yatabe, Y; Yoshino, T; Baba, E

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 28 ( 7 ) page: 827 - 840   2023.7

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  224. Niraparib as a therapeutic agent for the treatment of ovarian cancer meningeal dissemination with <i>BRCA1</i> mutation

    Nei, T; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Niimi, K; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 7 ) page: 1875 - 1879   2023.7

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  225. <i>Fusobacterium</i> infection facilitates the development of endometriosis through the phenotypic transition of endometrial fibroblasts

    Muraoka, A; Suzuki, M; Hamaguchi, T; Watanabe, S; Iijima, K; Murofushi, Y; Shinjo, K; Osuka, S; Hariyama, Y; Ito, M; Ohno, K; Kiyono, T; Kyo, S; Iwase, A; Kikkawa, F; Kajiyama, H; Kondo, Y

    SCIENCE TRANSLATIONAL MEDICINE   Vol. 15 ( 700 ) page: eadd1531   2023.6

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  226. Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakamura, N; Iitani, Y; Moriyama, Y; Emoto, R; Kato, S; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Matsui, S; Kajiyama, H

    DIABETOLOGY & METABOLIC SYNDROME   Vol. 15 ( 1 ) page: 123   2023.6

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  227. Downregulating vaccinia-related kinase 1 by luteolin suppresses ovarian cancer cell proliferation by activating the p53 signaling pathway

    Chang, X; Tamauchi, S; Yoshida, K; Yoshihara, M; Yokoi, A; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Kiyono, T; Yamamoto, Y; Kajiyama, H

    GYNECOLOGIC ONCOLOGY   Vol. 173   page: 31 - 40   2023.6

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  228. Homologous recombination inquiry through ovarian malignancy investigations: JGOG3025 Study

    Yoshihara, K; Baba, T; Tokunaga, H; Nishino, K; Sekine, M; Takamatsu, S; Matsumura, N; Yoshida, H; Kajiyama, H; Shimada, M; Kagimura, T; Oda, K; Sasajima, Y; Yaegashi, N; Okamoto, A; Sugiyama, T; Enomoto, T

    CANCER SCIENCE   Vol. 114 ( 6 ) page: 2515 - 2523   2023.6

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  229. An attempt to establish real-world databases of poly(ADP-ribose) polymerase inhibitors for advanced or recurrent epithelial ovarian cancer: the Japanese Gynecologic Oncology Group

    Shimada, M; Yoshihara, K; Tanigawa, T; Nomura, H; Hamanishi, J; Fujiwara, S; Tanabe, H; Kajiyama, H; Mandai, M; Aoki, D; Enomoto, T; Okamoto, A

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 34 ( 3 ) page: e62   2023.5

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  230. Downregulation of miR-10b-5p facilitates the proliferation of uterine leiomyosarcoma cells: A microRNA sequencing-based approach

    Yoshida, K; Yokoi, A; Kitagawa, M; Sugiyama, M; Yamamoto, T; Nakayama, J; Yoshida, H; Kato, T; Kajiyama, H; Yamamoto, Y

    ONCOLOGY REPORTS   Vol. 49 ( 5 )   2023.5

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  231. Organic decomposition and synthesis reactions in lactated solution exposed to nonequilibrium atmospheric pressure plasma

    Liu, Y; Ishikawa, K; Tanaka, H; Miron, C; Kondo, T; Nakamura, K; Mizuno, M; Kajiyama, H; Toyokuni, S; Hori, M

    PLASMA PROCESSES AND POLYMERS   Vol. 20 ( 5 )   2023.5

  232. Preoperative serum microRNAs as potential prognostic biomarkers in ovarian clear cell carcinoma

    Suzuki, K; Yokoi, A; Yoshida, K; Kato, T; Ochiya, T; Yamamoto, Y; Kajiyama, H

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 34 ( 3 ) page: e34   2023.5

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  233. The association of UBAP2L and G3BP1 mediated by small nucleolar RNA is essential for stress granule formation

    Asano-Inami, E; Yokoi, A; Sugiyama, M; Hyodo, T; Hamaguchi, T; Kajiyama, H

    COMMUNICATIONS BIOLOGY   Vol. 6 ( 1 ) page: 415   2023.4

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  234. Prognostic relevance of HRDness gene expression signature in ovarian high-grade serous carcinoma; JGOG3025-TR2 study

    Takamatsu, S; Yoshihara, K; Baba, T; Shimada, M; Yoshida, H; Kajiyama, H; Oda, K; Mandai, M; Okamoto, A; Enomoto, T; Matsumura, N

    BRITISH JOURNAL OF CANCER   Vol. 128 ( 6 ) page: 1095 - 1104   2023.4

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  235. Antenatal corticosteroids-to-delivery interval associates cord blood S100B levels

    Fuma, K; Kotani, T; Ushida, T; Imai, K; Iitani, Y; Nakamura, N; Miki, R; Katsuki, S; Kinoshita, F; Sato, Y; Hayakawa, M; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 4 ) page: 1129 - 1136   2023.4

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  236. Clinical significances of Bishop score and vaginal bleeding to controlled-release dinoprostone delivery system (PROPESS) efficacy for cervical ripening: A retrospective single-center study in Japan

    Imai, K; Aoki, C; Tano, S; Iitani, Y; Nakamura, N; Ushida, T; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 49 ( 4 ) page: 1154 - 1160   2023.4

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  237. Upregulated Ribosomal Pathway Impairs Follicle Development in a Polycystic Ovary Syndrome Mouse Model: Differential Gene Expression Analysis of Oocytes

    Nakanishi, N; Osuka, S; Kono, T; Kobayashi, H; Ikeda, S; Bayasula, B; Sonehara, R; Murakami, M; Yoshita, S; Miyake, N; Muraoka, A; Kasahara, Y; Murase, T; Nakamura, T; Goto, M; Iwase, A; Kajiyama, H

    REPRODUCTIVE SCIENCES   Vol. 30 ( 4 ) page: 1306 - 1315   2023.4

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  238. Generation and measurement of low-temperature plasma for cancer therapy: a historical review

    Ishikawa, K; Takeda, K; Yoshimura, S; Kondo, T; Tanaka, H; Toyokuni, S; Nakamura, K; Kajiyama, H; Mizuno, M; Hori, M

    FREE RADICAL RESEARCH   Vol. 57 ( 3 ) page: 239 - 270   2023.3

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  239. Indoxyl Sulfate Promotes Metastatic Characteristics of Ovarian Cancer Cells via Aryl Hydrocarbon Receptor-Mediated Downregulation of the Mas Receptor

    Saito, S; Koya, Y; Kajiyama, H; Yamashita, M; Nawa, A

    LABORATORY INVESTIGATION   Vol. 103 ( 3 ) page: 100025   2023.3

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  240. Novel therapeutic strategies targeting UCP2 in uterine leiomyosarcoma

    Nagao, Y; Yokoi, A; Yoshida, K; Sugiyama, M; Watanabe, E; Nakamura, K; Kitagawa, M; Asano-Inami, E; Koya, Y; Yoshihara, M; Tamauchi, S; Shimizu, Y; Ikeda, Y; Yoshikawa, N; Kato, T; Yamamoto, Y; Kajiyama, H

    PHARMACOLOGICAL RESEARCH   Vol. 189   page: 106693   2023.3

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  241. Cancer-specific cytotoxicity of Ringer's acetate solution irradiated by cold atmospheric pressure plasma

    Miron, C; Ishikawa, K; Kashiwagura, S; Suda, Y; Tanaka, H; Nakamura, K; Kajiyama, H; Toyokuni, S; Mizuno, M; Hori, M

    FREE RADICAL RESEARCH   Vol. 57 ( 2 ) page: 91 - 104   2023.2

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  242. Current understanding of plasma-activated solutions for potential cancer therapy

    Yoshikawa, N; Nakamura, K; Kajiyama, H

    FREE RADICAL RESEARCH   Vol. 57 ( 2 ) page: 69 - 80   2023.2

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  243. Aberrant activation of cell cycle-related kinases as novel therapeutic targets for uterine leiomyosarcoma

    Yoshida, K; Yokoi, A; Kato, T; Kajiyama, H; Yamamoto, Y

    CANCER SCIENCE   Vol. 114   page: 1457 - 1457   2023.2

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  244. Aberrant activation of cell cycle-related kinases as novel therapeutic targets for uterine leiomyosarcoma

    Yoshida, K; Yokoi, A; Kato, T; Kajiyama, H; Yamamoto, Y

    CANCER SCIENCE   Vol. 114   page: 913 - 913   2023.2

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  245. CD271 contributes to progression of ovarian cancer via promoting cell migration and invasion

    Miyamoto, E; Koya, Y; Yoshihara, M; Sugiyama, M; Iyoshi, S; Kitami, K; Uno, K; Mogi, K; Fujimoto, H; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 364 - 364   2023.2

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  246. Cooperation of Poly(rC)-binding Proteins 1/2 and Glutathione in Ferroptosis Induced by Plasmaactivated Ringer's Lactate

    Zheng, H; Jiang, L; Lyu, QY; Akatsuka, S; Motooka, Y; Sekido, Y; Nakamura, K; Tanaka, H; Ishikawa, K; Kajiyama, H; Mizuno, M; Hori, M; Toyokuni, S

    CANCER SCIENCE   Vol. 114   page: 1340 - 1340   2023.2

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  247. Cooperation of Poly(rC)-binding Proteins 1/2 and Glutathione in Ferroptosis Induced by Plasma-activated Ringer's Lactate

    Zheng, H; Jiang, L; Lyu, QY; Akatsuka, S; Motooka, Y; Sekido, Y; Nakamura, K; Tanaka, H; Ishikawa, K; Kajiyama, H; Mizuno, M; Hori, M; Toyokuni, S

    CANCER SCIENCE   Vol. 114   page: 749 - 749   2023.2

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  248. Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma

    Watanabe, E; Yokoi, A; Yoshida, K; Sugiyama, M; Kitagawa, M; Nishino, K; Yamamoto, E; Niimi, K; Yamamoto, Y; Kajiyama, H

    CANCER MEDICINE   Vol. 12 ( 4 ) page: 4543 - 4556   2023.2

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  249. Impact of obesity and the role of dedifferentiated adipocytes upon peritoneal metastasis of ovarian cancer

    Iyoshi, S; Yoshihara, M; Nakamura, K; Sumi, A; Sugiyama, M; Koya, Y; Miyamoto, E; Fujimoto, H; Mogi, K; Uno, K; Kitami, K; Emoto, R; Matsui, S; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 978 - 978   2023.2

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  250. Identifying Copy Number Variations in Extracellular Vesicles as a Novel Biomarker of High Grade Serous Ovarian Carcinoma

    Uekusa, R; Yokoi, A; Kitagawa, M; Yoshida, K; Yoshihara, M; Tamauchi, S; Niimi, K; Matsuzaki, J; Yamamoto, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 1063 - 1063   2023.2

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  251. Establishing the novel experimental model of tumor-associated fibrosis for ovarian cancer's metastasis

    Fujimoto, H; Yoshihara, M; Yamakita, Y; Sugiyama, M; Koya, Y; Miyamoto, E; Mogi, K; Uno, K; Iyoshi, S; Kitami, K; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 1223 - 1223   2023.2

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  252. Lineage tracing and functional analysis of ovarian cancer-associated mesothelial cells

    Mogi, K; Yoshihara, M; Taniguchi, T; Yamakita, Y; Miyamoto, E; Fujimoto, H; Kitami, K; Iyoshi, S; Uno, K; Sugiyama, M; Koya, Y; Tomita, H; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 1222 - 1222   2023.2

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  253. Preoperative serum microRNAs as potential prognostic biomarkers in ovarian clear cell carcinoma

    Suzuki, K; Yokoi, A; Yoshida, K; Kato, T; Ochiya, T; Yamamoto, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 1986 - 1986   2023.2

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  254. Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of TGF-β1/THBS1

    Kitami, K; Yoshihara, M; Yamakita, Y; Sugiyama, M; Koya, Y; Miyamoto, E; Fujimoto, H; Iyoshi, S; Uno, K; Mogi, K; Kato, K; Nawa, A; Enomoto, A; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 1047 - 1047   2023.2

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  255. Novel exosome analyses for micro volume ascites in ovarian cancer dissemination

    Yokoi, A; Yasui, T; Yoshida, K; Kitagawa, M; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 20 - 20   2023.2

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  256. Notch signaling can be a new therapeutic target for advanced ovarian cancer

    Sugiyama, M; Yoshihara, M; Koya, Y; Kitami, K; Uno, K; Iyoshi, S; Mogi, K; Yokoi, A; Nakamura, K; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 2065 - 2065   2023.2

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  257. Mesothelial cells that phagocytosed ovarian cancer cells have enhanced signals that suppress antitumor immunity

    Koya, Y; Kitami, K; Yoshihara, M; Sugiyama, M; Mogi, K; Uno, K; Iyoshi, S; Fujimoto, H; Miyamoto, E; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 1224 - 1224   2023.2

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  258. Mesothelial cell is a source of vascular component cells in peritoneal dissemination of ovarian cancer

    Taniguchi, T; Mogi, K; Tomita, H; Yamakita, Y; Yoshihara, M; Fujimoto, H; Uno, K; Sugiyama, M; Koya, Y; Niwa, A; Kinoshita, T; Nawa, A; Kajiyama, H; Hara, A

    CANCER SCIENCE   Vol. 114   page: 1899 - 1899   2023.2

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  259. Tumor suppressive miRNAs in small extracellular vesicles derived from ADSCs shows anti-tumor capacity in ovarian cancer

    Suzuki, H; Yokoi, A; Uekusa, R; Kitagawa, M; Yoshida, K; Uno, K; Kajiyama, H

    CANCER SCIENCE   Vol. 114   page: 1374 - 1374   2023.2

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  260. Validation of reduced ovarian reserve in BRCA1 haploinsufficient rats

    Sonehara, R; Motooka, Y; Kajiyama, H; Mashimo, T; Imaoka, T; Toyokuni, S

    CANCER SCIENCE   Vol. 114   page: 2041 - 2041   2023.2

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  261. Trend changes in age-related body mass index gain after coronavirus disease 2019 pandemic in Japan: a multicenter retrospective cohort study

    Tano, S; Kotani, T; Ushida, T; Iitani, Y; Imai, K; Kinoshita, F; Kajiyama, H

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 21 ( 1 ) page: 7   2023.1

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  262. Plasma activated Ringer's lactate solution

    Tanaka, H; Mizuno, M; Ishikawa, K; Miron, C; Okazaki, Y; Toyokuni, S; Nakamura, K; Kajiyama, H; Hori, M

    FREE RADICAL RESEARCH   Vol. 57 ( 1 ) page: 14 - 20   2023.1

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  263. Association Between Anti-Mullerian Hormone Levels and Polycystic Ovarian Syndrome in a General Cohort of Young Women in Japan

    Miyake, N; Osuka, S; Goto, M; Seki, T; Muraoka, A; Nakanishi, N; Nakamura, T; Iwase, A; Kajiyama, H

    REPRODUCTIVE SCIENCES   Vol. 30   page: 172A - 172A   2023.1

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  264. Disabled-2 (<i>DAB2</i>): A Key Regulator of Anti- and Pro-Tumorigenic Pathways

    Price, ZK; Lokman, NA; Yoshihara, M; Kajiyama, H; Oehler, MK; Ricciardelli, C

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 24 ( 1 )   2023.1

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  265. Follicle development and its prediction in patients with primary ovarian insufficiency: Possible treatments and markers to maximize the ability to conceive with residual follicles

    Osuka, S; Kasahara, Y; Iyoshi, S; Sonehara, R; Myake, N; Muraoka, A; Nakamura, T; Iwase, A; Kajiyama, H

    REPRODUCTIVE MEDICINE AND BIOLOGY   Vol. 22 ( 1 ) page: e12556   2023.1

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  266. Unkeito (Wen-jing-tang) Decreases Ovulation Disorder in a Rat Model of Polycystic Ovary Syndrome

    Osuka, S; Yoshita, S; Shimizu, T; Matsumoto, C; Seki, T; Miyake, N; Sonehara, R; Muraoka, A; Nananishi, N; Nakamura, T; Kajiyama, H

    REPRODUCTIVE SCIENCES   Vol. 30   page: 250A - 251A   2023.1

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  267. The prognostic significance of DDIT4 in endometrial cancer

    Yoshikawa, N; Yoshida, K; Liu, WT; Matsukawa, T; Hattori, S; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yokoi, A; Shimizu, Y; Niimi, K; Kajiyama, H

    CANCER BIOMARKERS   Vol. 37 ( 4 ) page: 217 - 225   2023

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  268. Prenatal diagnosis of distal 13q deletion syndrome in a fetus with esophageal atresia: a case report and review of the literature

    Kotani, T; Tsuda, H; Ito, Y; Nakamura, N; Ushida, T; Imai, K; Iitani, Y; Fuma, K; Muramatsu, Y; Hayakawa, M; Kajiyama, H

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 16 ( 1 ) page: 481   2022.12

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  269. Aberrant inflammation in rat pregnancy leads to cardiometabolic alterations in their offspring and intrauterine growth restriction in the F2 generation Open Access

    Ushida, T; Cotechini, T; Protopapas, N; Atallah, A; Collyer, C; Toews, AJ; Macdonald-Goodfellow, SK; Tse, MY; Winn, LM; Pang, SC; Adams, MA; Othman, M; Kotani, T; Kajiyama, H; Graham, CH

    JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE   Vol. 13 ( 6 ) page: 706 - 718   2022.12

  270. Tamoxifen Activates Dormant Primordial Follicles in Mouse Ovaries Open Access

    Wei, W; Komatsu, K; Osuka, S; Murase, T; Bayasula, B; Nakanishi, N; Nakamura, T; Goto, M; Iwase, A; Masubuchi, S; Kajiyama, H

    REPRODUCTIVE SCIENCES   Vol. 29 ( 12 ) page: 3404 - 3412   2022.12

  271. A case of non-immune hydrops fetalis with maternal mirror syndrome diagnosed by trio-based exome sequencing: An autopsy case report and literature review

    Tano, S; Kotani, T; Yoshihara, M; Nakamura, N; Matsuo, S; Ushida, T; Imai, K; Ito, M; Oka, Y; Sato, E; Hayashi, S; Ogi, T; Kajiyama, H

    MOLECULAR GENETICS AND METABOLISM REPORTS   Vol. 33   page: 100925   2022.12

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  272. Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells

    Aoki, C; Imai, K; Mizutani, T; Sugiyama, D; Miki, R; Koya, Y; Kobayashi, T; Ushida, T; Iitani, Y; Nakamura, N; Owaki, T; Nishikawa, H; Toyokuni, S; Kajiyama, H; Kotani, T

    LIFE SCIENCES   Vol. 308   page: 120955   2022.11

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  273. 5p deletion with congenital diaphragmatic hernia: a case report

    Kotani, T; Ushida, T; Nakamura, N; Imai, K; Iitani, Y; Tano, S; Iwagaki, S; Takahashi, Y; Ito, M; Hayakawa, M; Kajiyama, H

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 16 ( 1 ) page: 390   2022.10

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  274. Optimal annual body mass index change for preventing spontaneous preterm birth in a subsequent pregnancy

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Iitani, Y; Kinoshita, F; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 17502   2022.10

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  275. DEVELOPING OF A NOVEL THERAPEUTIC AGENT FOR FGR THROUGH DRUG REPOSITIONING

    Tano, S; Kotani, T; Ushida, T; Nakamura, N; Iitani, Y; Yoshihara, M; Imai, K; Kajiyama, H

    PLACENTA   Vol. 128   page: 124 - 124   2022.10

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  276. INVESTIGATION OF NK CELL IMMUNITY SURROUNDING CHORIOCARCINOMA

    Shibata, M; Niimi, K; Yasui, Y; Nishiko, Y; Oda, Y; Nishino, K; Yamamoto, E; Kajiyama, H

    PLACENTA   Vol. 128   page: 126 - 126   2022.10

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  277. Regulation of Mesothelial Cell Fate during Development and Human Diseases

    Taniguchi, T; Tomita, H; Kanayama, T; Mogi, K; Koya, Y; Yamakita, Y; Yoshihara, M; Kajiyama, H; Hara, A

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 23 ( 19 )   2022.10

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  278. UNIQUE GENOMIC PROFILES OF CHORIOCARCINOMA BASED ON WHOLE EXOME SEQUENCING ANALYSIS

    Oda, Y; Niimi, K; Yasui, Y; Nishiko, Y; Shibata, M; Nishino, K; Yamamoto, E; Kajiyama, H

    PLACENTA   Vol. 128   page: 129 - 129   2022.10

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  279. Who are the long-term survivors of recurrent ovarian carcinoma?: a retrospective analysis of a multicenter study

    Yoshihara, M; Mogi, K; Kitami, K; Uno, K; Iyoshi, S; Tano, S; Fujimoto, H; Miyamoto, E; Yoshikawa, N; Emoto, R; Matsui, S; Kajiyama, H

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 27 ( 10 ) page: 1660 - 1668   2022.10

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  280. Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer

    Yoshikawa, N; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yokoi, A; Kajiyama, H

    PLOS ONE   Vol. 17 ( 9 ) page: e0273876   2022.9

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  281. Severe Congenital Diaphragmatic Hernia With Trisomy 9: A Case Report and Review of the Literature

    Fuma, K; Kotani, T; Nakamura, N; Ushida, T; Kajiyama, H

    CUREUS JOURNAL OF MEDICAL SCIENCE   Vol. 14 ( 8 ) page: e28395   2022.8

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  282. Impact of hypertensive disorders of pregnancy on respiratory outcomes in extremely and very preterm infants: A population-based study in Japan

    Ushida, T; Nakamura, N; Nakatochi, M; Kobayashi, Y; Sato, Y; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H; Kotani, T

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 29   page: 54 - 60   2022.8

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  283. Obesity contributes to the stealth peritoneal dissemination of ovarian cancer: a multi-institutional retrospective cohort study

    Iyoshi, S; Sumi, A; Yoshihara, M; Kitami, K; Mogi, K; Uno, K; Fujimoto, H; Miyamoto, E; Tano, S; Yoshikawa, N; Emoto, R; Matsui, S; Kajiyama, H

    OBESITY   Vol. 30 ( 8 ) page: 1599 - 1607   2022.8

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  284. Predictive factors for massive hemorrhage in women with retained products of conception: a prospective study

    Sonehara, R; Nakamura, T; Iwase, A; Nishida, K; Takikawa, S; Murakami, M; Yoshita, S; Muraoka, A; Miyake, N; Nakanishi, N; Osuka, S; Goto, M; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 11859   2022.7

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  285. Machine learning prediction models for postpartum depression: A multicenter study in Japan

    Matsuo, S; Ushida, T; Emoto, R; Moriyama, Y; Iitani, Y; Nakamura, N; Imai, K; Nakano-Kobayashi, T; Yoshida, S; Yamashita, M; Matsui, S; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1775 - 1785   2022.7

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  286. Reassessing the duration of each stage of labor and their relation to postpartum hemorrhage in the current Japanese population Open Access

    Ushida, T; Matsuo, S; Nakamura, N; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 7 ) page: 1760 - 1767   2022.7

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  287. Survival benefits of retroperitoneal lymphadenectomy for optimally-resected advanced ovarian high-grade serous carcinoma: a multi-institutional retrospective study Open Access

    Ikeda, Y; Yoshihara, M; Tamauchi, S; Yokoi, A; Yoshikawa, N; Kajiyama, H

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 33 ( 4 ) page: e40   2022.7

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  288. Bevacizumab in first-line chemotherapy to improve the survival outcome for advanced ovarian clear cell carcinoma: A multicenter, retrospective analysis.

    Seki, T; Tate, S; Nishikimi, K; Unno, Y; Itoi, M; Ikeda, S; Yoshikawa, N; Akashi, H; Suzuki, E; Tanaka, N; Hirakawa, T; Kajiyama, H; Takano, H; Yoshihara, K; Okamoto, A; Shozu, M

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 40 ( 16 )   2022.6

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  289. Intrauterine exposure to hypertensive disorders of pregnancy and postnatal growth in extremely and very preterm infants Open Access

    Ushida, T; Kotani, T; Nakatochi, M; Kobayashi, Y; Nakamura, N; Imai, K; Iitani, Y; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 28   page: 174 - 179   2022.6

  290. The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia

    Aoki, C; Imai, K; Owaki, T; Kobayashi-Nakano, T; Ushida, T; Iitani, Y; Nakamura, N; Kajiyama, H; Kotani, T

    MEDICINA-LITHUANIA   Vol. 58 ( 6 )   2022.6

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  291. Aberrant Activation of Cell-Cycle-Related Kinases and the Potential Therapeutic Impact of PLK1 or CHEK1 Inhibition in Uterine Leiomyosarcoma Open Access

    Yoshida, K; Yokoi, A; Yamamoto, T; Hayashi, Y; Nakayama, J; Yokoi, T; Yoshida, H; Kato, T; Kajiyama, H; Yamamoto, Y

    CLINICAL CANCER RESEARCH   Vol. 28 ( 10 ) page: 2147 - 2159   2022.5

  292. Cytotoxicity of plasma-irradiated lactate solution produced under atmospheric airtight conditions and generation of the methyl amino group

    Ito, D; Iwata, N; Ishikawa, K; Nakamura, K; Hashizume, H; Miron, C; Tanaka, H; Kajiyama, H; Toyokuni, S; Mizuno, M; Hori, M

    APPLIED PHYSICS EXPRESS   Vol. 15 ( 5 )   2022.5

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    DOI: 10.35848/1882-0786/ac6360

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  293. Is cystectomy an option as conservative surgery for young patients with borderline ovarian tumor? A multi-institutional retrospective study

    Ikeda, Y; Yoshihara, M; Yoshikawa, N; Tamauchi, S; Yokoi, A; Nishino, K; Niimi, K; Kajiyama, H

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS   Vol. 157 ( 2 ) page: 437 - 443   2022.5

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  294. Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis Open Access

    Kitami, K; Yoshihara, M; Tamauchi, S; Sugiyama, M; Koya, Y; Yamakita, Y; Fujimoto, H; Iyoshi, S; Uno, K; Mogi, K; Ikeda, Y; Yokoi, A; Yoshikawa, N; Nishino, K; Niimi, K; Nawa, A; Enomoto, A; Kajiyama, H

    MATRIX BIOLOGY   Vol. 109   page: 70 - 90   2022.5

  295. Pregnancy Outcomes in Women with Thyroid Diseases

    Kotani, T; Imai, K; Ushida, T; Moriyama, Y; Nakano-Kobayashi, T; Osuka, S; Tsuda, H; Sumigama, S; Yamamoto, E; Kinoshita, F; Hirakawa, A; Iwase, A; Kikkawa, F; Kajiyama, H

    JMA JOURNAL   Vol. 5 ( 2 ) page: 216 - 223   2022.4

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  296. Assessment of placental abruption with diffusion-weighted imaging

    Mizutani, T; Kotani, T; Kato, N; Imai, K; Ushida, T; Nakano-Kobayashi, T; Kinoshita, Y; Ito, M; Kinoshita, F; Yamamuro, O; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 4 ) page: 930 - 937   2022.4

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  297. Metastatic Voyage of Ovarian Cancer Cells in Ascites with the Assistance of Various Cellular Components Open Access

    Uno, K; Iyoshi, S; Yoshihara, M; Kitami, K; Mogi, K; Fujimoto, H; Sugiyama, M; Koya, Y; Yamakita, Y; Nawa, A; Kanayama, T; Tomita, H; Enomoto, A; Kajiyama, H

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 23 ( 8 )   2022.4

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  298. Crosstalk between foetal vasoactive peptide hormones and placental aminopeptidases regulates placental blood flow: Its significance in preeclampsia Open Access

    Yoshihara, M; Mizutani, S; Matsumoto, K; Kato, Y; Masuo, Y; Tano, S; Mizutani, H; Kotani, T; Mizutani, E; Shibata, K; Kajiyama, H

    PLACENTA   Vol. 121   page: 32 - 39   2022.4

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  299. Effectiveness of NLRP3 Inhibitor as a Non-Hormonal Treatment for ovarian endometriosis Open Access

    Murakami, M; Osuka, S; Muraoka, A; Hayashi, S; Bayasula; Kasahara, Y; Sonehara, R; Hariyama, Y; Shinjo, K; Tanaka, H; Miyake, N; Yoshita, S; Nakanishi, N; Nakamura, T; Goto, M; Kajiyama, H

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 20 ( 1 ) page: 58   2022.3

  300. Annual Body Mass Index Gain and Risk of Gestational Diabetes Mellitus in a Subsequent Pregnancy Open Access

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Iitani, Y; Kinoshita, F; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    FRONTIERS IN ENDOCRINOLOGY   Vol. 13   page: 815390   2022.3

  301. Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline Open Access

    Iwama, S; Kobayashi, T; Yasuda, Y; Okuji, T; Ito, M; Ando, M; Zhou, X; Yamagami, A; Onoue, T; Kawaguchi, Y; Miyata, T; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Hase, T; Morise, M; Wakahara, K; Yokota, K; Kato, M; Nishio, N; Tanaka, C; Miyata, K; Ogura, A; Ito, T; Sawada, T; Shimokata, T; Niimi, K; Ohka, F; Ishigami, M; Gotoh, M; Hashimoto, N; Saito, R; Kiyoi, H; Kajiyama, H; Ando, Y; Hibi, H; Sone, M; Akiyama, M; Kodera, Y; Arima, H

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   Vol. 107 ( 4 ) page: E1620 - E1630   2022.3

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  302. Is adjuvant chemotherapy necessary for young women with early-stage epithelial ovarian cancer who have undergone fertility-sparing surgery?: a multicenter retrospective analysis Open Access

    Ikeda, Y; Yoshihara, M; Yoshikawa, N; Yokoi, A; Tamauchi, S; Nishino, K; Niimi, K; Kajiyama, H

    BMC WOMENS HEALTH   Vol. 22 ( 1 ) page: 80   2022.3

  303. Significance of platinum distribution to predict platinum resistance in ovarian cancer after platinum treatment in neoadjuvant chemotherapy Open Access

    Uno, K; Yoshikawa, N; Tazaki, A; Ohnuma, S; Kitami, K; Iyoshi, S; Mogi, K; Yoshihara, M; Koya, Y; Sugiyama, M; Tamauchi, S; Ikeda, Y; Yokoi, A; Kikkawa, F; Kato, M; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 4513   2022.3

  304. Functional Lactotrophs in Induced Adenohypophysis Differentiated From Human iPS Cells Open Access

    Miyake, N; Nagai, T; Suga, H; Osuka, S; Kasai, T; Sakakibara, M; Soen, M; Ozaki, H; Miwata, T; Asano, T; Kano, M; Muraoka, A; Nakanishi, N; Nakamura, T; Goto, M; Yasuda, Y; Kawaguchi, Y; Miyata, T; Kobayashi, T; Sugiyama, M; Onoue, T; Hagiwara, D; Iwama, S; Iwase, A; Inoshita, N; Arima, H; Kajiyama, H

    ENDOCRINOLOGY   Vol. 163 ( 3 )   2022.3

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  305. Adjuvant taxane plus platinum chemotherapy for stage I ovarian clear cell carcinoma with complete surgical staging: are more than three cycles necessary?

    Ukai, M; Suzuki, S; Yoshihara, M; Yokoi, A; Yoshikawa, N; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 27 ( 3 ) page: 609 - 618   2022.3

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  306. Survival and reproductive outcomes after fertility-sparing surgery performed for borderline epithelial ovarian tumor in Japanese adolescents and young adults: Results of a retrospective nationwide study

    Kuji, S; Harada, M; Yoshioka, N; Kajiyama, H; Satoh, T; Mikami, M; Shozu, M; Enomoto, T; Osuga, Y; Suzuki, N

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 48 ( 3 ) page: 806 - 816   2022.3

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  307. Frequency of homologous recombination deficiency in high-grade serous ovarian cancer in Japan; JGOG3025-TR2 study

    Matsumura, N; Takamatsu, S; Yoshihara, K; Baba, T; Shimada, M; Yoshida, H; Okamoto, A; Kajiyama, H; Oda, K; Enomoto, T

    CANCER SCIENCE   Vol. 113   page: 827 - 827   2022.2

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  308. Discovering novel therapeutic agents for uterine leiomyosarcoma

    Nagao, Y; Yokoi, A; Yoshida, K; Watanabe, E; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Yamamoto, Y; Kato, T; Kajiyama, H

    CANCER SCIENCE   Vol. 113   page: 1181 - 1181   2022.2

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  309. Chemical library-based drug repositioning strategy for choriocarcinoma therapy

    Watanabe, E; Yokoi, A; Yoshida, K; Yamamoto, Y; Nishino, K; Niimi, K; Kajiyama, H

    CANCER SCIENCE   Vol. 113   page: 1501 - 1501   2022.2

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  310. Anti-tumor capacity of specific contents in small extracellular vesicles derived from ADSCs in ovarian cancer

    Yokoi, A; Yoshida, K; Uno, K; Kajiyama, H

    CANCER SCIENCE   Vol. 113   page: 1408 - 1408   2022.2

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  311. Adipose-mesothelial crosstalk regulates peritoneal tumor microenvironment and accelerates metastasis of ovarian cancer

    Mogi, K; Yoshihara, M; Uno, K; Iyoshi, S; Kitami, K; Sugiyama, M; Koya, Y; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 113   page: 735 - 735   2022.2

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  312. NGFR contributes the malignancy of ovarian carcinoma cells

    Koya, Y; Sugiyama, M; Yoshihara, M; Kitami, K; Uno, K; Mogi, K; Iyoshi, S; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 113   page: 1033 - 1033   2022.2

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  313. Vitamin D inhibits mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer via THBS1

    Kitami, K; Yoshihara, M; Sugiyama, M; Koya, Y; Yamakita, Y; Iyoshi, S; Uno, K; Mogi, K; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nishino, K; Niimi, K; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 113   page: 729 - 729   2022.2

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  314. Prognostic impact of extracellular miRNAs in patients with high-grade serous ovarian carcinoma

    Yoshida, K; Yokoi, A; Matsuzaki, J; Kato, T; Ochiya, T; Kajiyama, H; Yamamoto, Y

    CANCER SCIENCE   Vol. 113   page: 1788 - 1788   2022.2

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  315. Pre-pregnancy sleep duration and postpartum depression: a multicenter study in Japan

    Matsuo, S; Ushida, T; Iitani, Y; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    ARCHIVES OF WOMENS MENTAL HEALTH   Vol. 25 ( 1 ) page: 181 - 189   2022.2

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  316. Notch-dependent intra-tumoral heterogeneity mediates cell-fate dynamics and development of peritoneal dissemination

    Yoshihara, M; Sugiyama, M; Koya, Y; Iyoshi, S; Kitami, K; Uno, K; Mogi, K; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 113   page: 1405 - 1405   2022.2

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  317. Notch signaling contributes to drug resistance acquisition through metabolic alteration in advanced ovarian cancer

    Sugiyama, M; Yoshihara, M; Koya, Y; Kitami, K; Uno, K; Iyoshi, S; Mogi, K; Yokoi, A; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 113   page: 1280 - 1280   2022.2

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  318. Enhancement of ethanol production and cell growth in budding yeast by direct irradiation of low-temperature plasma Open Access

    Tanaka, H; Matsumura, S; Ishikawa, K; Hashizume, H; Ito, M; Nakamura, K; Kajiyama, H; Kikkawa, F; Ito, M; Ohno, K; Okazaki, Y; Toyokuni, S; Mizuno, M; Hori, M

    JAPANESE JOURNAL OF APPLIED PHYSICS   Vol. 61 ( SA )   2022.1

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  319. Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma Open Access

    Nishino, K; Nishiko, Y; Shibata, M; Oda, Y; Watanabe, E; Niimi, K; Yamamoto, E; Kajiyama, H

    PLACENTA   Vol. 117   page: 109 - 117   2022.1

  320. Laparoscopic pelvic surgery after reconstructive surgery with vertical rectus abdominis muscle flap: A case report Open Access

    Nishino, K; Ikeda, Y; Kitami, K; Niimi, K; Kajiyama, H

    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS   Vol. 90   page: 106706   2022.1

  321. Clinical practice guideline for the treatment of malignant ascites: section summary in Clinical Practice Guideline for peritoneal dissemination (2021) Open Access

    Matsusaki, K; Aridome, K; Emoto, S; Kajiyama, H; Takagaki, N; Takahashi, T; Tsubamoto, H; Nagao, S; Watanabe, A; Shimada, H; Kitayama, J

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 27 ( 1 ) page: 1 - 6   2022.1

  322. Placental Leucine Aminopeptidase as a Potential Specific Urine Biomarker for Invasive Ovarian Cancer Open Access

    Matsukawa, T; Mizutani, S; Matsumoto, K; Kato, Y; Yoshihara, M; Kajiyama, H; Shibata, K

    JOURNAL OF CLINICAL MEDICINE   Vol. 11 ( 1 )   2022.1

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  323. Liver transaminase levels during pregnancy: a Japanese multicenter study

    Ushida, T; Kotani, T; Kinoshita, F; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE   Vol. 35 ( 25 ) page: 5761 - 5767   2022

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  324. Impact of perioperative use of GnRH agonist or dienogest on ovarian reserve after cystectomy for endometriomas: a randomized controlled trial Open Access

    Muraoka, A; Osuka, S; Yabuki, A; Bayasula; Yoshihara, M; Tanaka, H; Sonehara, R; Miyake, N; Murakami, M; Yoshita, S; Nakanishi, N; Nakamura, T; Goto, M; Iwase, A; Kajiyama, H

    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY   Vol. 19 ( 1 ) page: 179   2021.12

  325. Clinical effects of cervical conization with positive margins in cervical cancer Open Access

    Nagao, Y; Yokoi, A; Yoshida, K; Sumi, M; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 23288   2021.12

  326. Pro-tumoral behavior of omental adipocyte-derived fibroblasts in tumor microenvironment at the metastatic site of ovarian cancer Open Access

    Iyoshi, S; Yoshihara, M; Nakamura, K; Sugiyama, M; Koya, Y; Kitami, K; Uno, K; Mogi, K; Tano, S; Tomita, H; Kajiwara, K; Taki, M; Yamaguchi, S; Nawa, A; Kajiyama, H

    INTERNATIONAL JOURNAL OF CANCER   Vol. 149 ( 11 ) page: 1961 - 1972   2021.12

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  327. Extracellular microRNA profiling for prognostic prediction in patients with high-grade serous ovarian carcinoma Open Access

    Yoshida, K; Yokoi, A; Matsuzaki, J; Kato, T; Ochiya, T; Kajiyama, H; Yamamoto, Y

    CANCER SCIENCE   Vol. 112 ( 12 ) page: 4977 - 4986   2021.12

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  328. Long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery for epithelial ovarian cancer Open Access

    Shigeyama, M; Yoshihara, M; Kitami, K; Mogi, K; Uno, K; Iyoshi, S; Tano, S; Yoshikawa, N; Kajiyama, H

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 267   page: 221 - 225   2021.12

  329. Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study Open Access

    Katsuki, S; Ushida, T; Kidokoro, H; Nakamura, N; Iitani, Y; Fuma, K; Imai, K; Nakano-Kobayashi, T; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    EARLY HUMAN DEVELOPMENT   Vol. 163   page: 105479   2021.12

  330. Prevalence and risk factors of labor-onset hypertension: A multicenter study in Japan Open Access

    Ushida, T; Kotani, T; Imai, K; Nakano-Kobayashi, T; Iitani, Y; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 26   page: 48 - 53   2021.12

  331. Recent Insights into Human Endometrial Peptidases in Blastocyst Implantation via Shedding of Microvesicles Open Access

    Yoshihara, M; Mizutani, S; Kato, Y; Matsumoto, K; Mizutani, E; Mizutani, H; Fujimoto, H; Osuka, S; Kajiyama, H

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 22 ( 24 )   2021.12

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  332. Annual body mass index gain and risk of hypertensive disorders of pregnancy in a subsequent pregnancy Open Access

    Tano, S; Kotani, T; Ushida, T; Yoshihara, M; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Iitani, Y; Kinoshita, F; Yoshida, S; Yamashita, M; Kishigami, Y; Oguchi, H; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 22519   2021.11

  333. Achievement of live birth after overcoming two gynecological malignancies treated with radical trachelectomy and medroxyprogesterone acetate therapy

    Tamauchi, S; Moriyama, Y; Suzuki, S; Ikeda, Y; Yoshikawa, N; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 11 ) page: 4101 - 4105   2021.11

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  334. Manual removal of the placenta and postpartum hemorrhage: A multicenter retrospective study Open Access

    Fujita, K; Ushida, T; Imai, K; Nakano-Kobayashi, T; Iitani, Y; Matsuo, S; Yoshida, S; Yamashita, M; Kajiyama, H; Kotani, T

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 11 ) page: 3867 - 3874   2021.11

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  335. Upregulation of ENDOU in cytotrophoblasts from placenta complicated with preeclampsia and fetal growth restriction Open Access

    Nomoto, M; Kotani, T; Miki, R; Ushida, T; Imai, K; Iitani, Y; Tano, S; Wang, JW; Moriyama, Y; Kobayashi, T; Mimura, N; Iriyama, T; Kikkawa, F; Kajiyama, H

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 69 ( 3 ) page: 280 - 285   2021.11

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  336. Heat Shock Protein 105 as an Immunotherapeutic Target for Patients With Cervical Cancer Open Access

    Nosaka, K; Suzuki, S; Yoshikawa, T; Shimomura, M; Kitami, K; Yoshida, K; Yoshihara, M; Kikkawa, F; Nakatsura, T; Kajiyama, H

    ANTICANCER RESEARCH   Vol. 41 ( 10 ) page: 4741 - 4751   2021.10

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  337. Plasma-activated Ringer's lactate solution inhibits the cellular respiratory system in HeLa cells

    Tanaka, H; Maeda, S; Nakamura, K; Hashizume, H; Ishikawa, K; Ito, M; Ohno, K; Mizuno, M; Motooka, Y; Okazaki, Y; Toyokuni, S; Kajiyama, H; Kikkawa, F; Hori, M

    PLASMA PROCESSES AND POLYMERS   Vol. 18 ( 10 )   2021.10

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    DOI: 10.1002/ppap.202100056

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  338. Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified Open Access

    Tanaka, H; Hosoi, Y; Ishikawa, K; Yoshitake, J; Shibata, T; Uchida, K; Hashizume, H; Mizuno, M; Okazaki, Y; Toyokuni, S; Nakamura, K; Kajiyama, H; Kikkawa, F; Hori, M

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 18488   2021.9

  339. Short tandem repeat analysis to identify the causative pregnancy of high-risk gestational trophoblastic neoplasia: Molar versus nonmolar pregnancy and its relation to the outcome Open Access

    Nishino, K; Yamamoto, E; Oda, Y; Watanabe, E; Niimi, K; Yamamoto, T; Kajiyama, H

    PLACENTA   Vol. 112   page: 28 - 35   2021.9

  340. Current Issues within the Perinatal Mental Health Care System in Aichi Prefecture, Japan: A Cross-Sectional Questionnaire Survey Open Access

    Fujita, K; Kotani, T; Moriyama, Y; Ushida, T; Imai, K; Kobayashi-Nakano, T; Kato, N; Kano, T; Kikkawa, F; Kajiyama, H

    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH   Vol. 18 ( 17 )   2021.9

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  341. Impact of incomplete surgery and adjuvant chemotherapy for the intraoperative rupture of capsulated stage I epithelial ovarian cancer: a multi-institutional study with an in-depth subgroup analysis Open Access

    Yoshihara, M; Tamauchi, S; Iyoshi, S; Kitami, K; Uno, K; Mogi, K; Kajiyama, H

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 32 ( 5 ) page: e66   2021.9

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  342. Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia Open Access

    Miura, M; Imai, K; Tsuda, H; Miki, R; Tano, S; Ito, Y; Hirako-Takamura, S; Moriyama, Y; Ushida, T; Iitani, Y; Nakano-Kobayashi, T; Toyokuni, S; Kajiyama, H; Kotani, T

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 22 ( 17 )   2021.9

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  343. Frequency of homologous recombination associated gene mutations in Japanese patients with ovarian cancer

    Yoshihara, K; Baba, T; Shimada, M; Yoshida, H; Okamoto, A; Kajiyama, H; Kagimura, T; Oda, K; Sugiyama, T; Enomoto, T

    GYNECOLOGIC ONCOLOGY   Vol. 162   page: S163 - S164   2021.8

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  344. Impact of maternal hypertensive disorders of pregnancy on brain volumes at term-equivalent age in preterm infants: A voxel-based morphometry study Open Access

    Ushida, T; Kidokoro, H; Nakamura, N; Katsuki, S; Imai, K; Nakano-Kobayashi, T; Moriyama, Y; Sato, Y; Hayakawa, M; Natsume, J; Kajiyama, H; Kotani, T

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 25   page: 143 - 149   2021.8

  345. A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer Open Access

    Yoshihara, M; Emoto, R; Kitami, K; Iyoshi, S; Uno, K; Mogi, K; Tano, S; Yoshikawa, N; Matsui, S; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 15154   2021.7

  346. Primate-specific POTE-actin gene could play a role in human folliculogenesis by controlling the proliferation of granulosa cells Open Access

    Kasahara, Y; Osuka, S; Takasaki, N; Bayasula; Koya, Y; Nakanishi, N; Murase, T; Nakamura, T; Goto, M; Iwase, A; Kajiyama, H

    CELL DEATH DISCOVERY   Vol. 7 ( 1 ) page: 186   2021.7

  347. Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity Open Access

    Nakamura, K; Niimi, K; Yamamoto, E; Ikeda, Y; Nishino, K; Suzuki, S; Kajiyama, H; Kikkawa, F

    BIOCHEMISTRY AND BIOPHYSICS REPORTS   Vol. 26   page: 100951   2021.7

  348. Reduced response to controlled ovarian stimulation after radical trachelectomy: A pitfall of fertility-sparing surgery for cervical cancer

    Tamauchi, S; Kajiyama, H; Osuka, S; Moriyama, Y; Yoshihara, M; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS   Vol. 154 ( 1 ) page: 162 - 168   2021.7

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  349. Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate Open Access

    Jiang, L; Zheng, H; Lyu, QY; Hayashi, S; Sato, K; Sekido, Y; Nakamura, K; Tanaka, H; Ishikawa, K; Kajiyama, H; Mizuno, M; Hori, M; Toyokuni, S

    REDOX BIOLOGY   Vol. 43   page: 101989   2021.7

  350. Next-generation genome sequencing of a matched normal-tumor pair from a patient with intractable gestational choriocarcinoma: A case report Open Access

    Niimi, K; Yamamoto, E; Morita, S; Morikawa, M; Hattori, H; Hatakeyama, M; Morita, M; Nishino, K; Oda, Y; Watanabe, E; Yamamoto, T; Kajiyama, H; Kikkawa, F

    MOLECULAR AND CLINICAL ONCOLOGY   Vol. 15 ( 1 ) page: 143   2021.7

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  351. Metabolome analysis reveals a diversity of cancer tissues in advanced epithelial ovarian cancer Open Access

    Yoshida, K; Yoshikawa, N; Kitami, K; Tamauchi, S; Ikeda, Y; Yokoi, A; Nishino, K; Niimi, K; Kajiyama, H

    CANCER CELL INTERNATIONAL   Vol. 21 ( 1 ) page: 314   2021.6

  352. Platelet counts during normal pregnancies and pregnancies complicated with hypertensive disorders Open Access

    Ushida, T; Kotani, T; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Kinoshita, F; Nakamura, N; Iitani, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 24   page: 73 - 78   2021.6

  353. Antenatal prediction models for short- and medium-term outcomes in preterm infants Open Access

    Ushida, T; Moriyama, Y; Nakatochi, M; Kobayashi, Y; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Hayakawa, M; Kajiyama, H; Kotani, T

    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA   Vol. 100 ( 6 ) page: 1089 - 1096   2021.6

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  354. Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer Open Access

    Hattori, S; Yoshikawa, N; Mogi, K; Yoshida, K; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yokoi, A; Nishino, K; Niimi, K; Suzuki, S; Kajiyama, H

    CURRENT ONCOLOGY   Vol. 28 ( 3 ) page: 1663 - 1672   2021.6

  355. Postpartum alterations following inflammation in rat pregnancy: a discovery proteomic analysis Open Access

    Ushida, T; Kotani, T; Moriyama, Y; Hindmarch, CCT; Cotechini, T; Imai, K; Nakano-Kobayashi, T; Kajiyama, H; Graham, CH

    REPRODUCTION   Vol. 161 ( 5 ) page: 513 - 522   2021.5

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  356. A poor prognostic metastatic nongestational choriocarcinoma of the ovary: a case report and the literature review Open Access

    Nishino, K; Yamamoto, E; Ikeda, Y; Niimi, K; Yamamoto, T; Kajiyama, H

    JOURNAL OF OVARIAN RESEARCH   Vol. 14 ( 1 ) page: 56   2021.4

  357. Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia

    Ito, Y; Tsuda, H; Imai, K; Miki, R; Miura, M; Tachi, A; Tano, S; Hirako-Takamura, S; Moriyama, Y; Ushida, T; Kobayashi, T; Sumigama, S; Kajiyama, H; Kikkawa, F; Kotani, T

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 700   page: 108769   2021.3

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  358. ChrXq27.3 miRNA cluster functions in cancer development Open Access

    Yoshida, K; Yokoi, A; Yamamoto, Y; Kajiyama, H

    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH   Vol. 40 ( 1 ) page: 112   2021.3

  359. Trisomy 5p with bilateral congenital diaphragmatic hernia: a case report Open Access

    Nakamura, N; Ushida, T; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Osuka, S; Goto, M; Kajiyama, H; Asada, H; Hayakawa, M; Kotani, T

    JOURNAL OF MEDICAL CASE REPORTS   Vol. 15 ( 1 ) page: 114   2021.3

  360. Shock Index and Postpartum Hemorrhage in Vaginal Deliveries: A Multicenter Retrospective Study

    Ushida, T; Kotani, T; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H; Kikkawa, F

    SHOCK   Vol. 55 ( 3 ) page: 332 - 337   2021.3

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  361. Maternal low birth weight and hypertensive disorders of pregnancy Open Access

    Ushida, T; Kotani, T; Kinoshita, F; Imai, K; Nakano-Kobayashi, T; Nakamura, N; Moriyama, Y; Yoshida, S; Yamashita, M; Kajiyama, H

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 23   page: 5 - 10   2021.3

  362. Preclinical Verification of the Efficacy and Safety of Aqueous Plasma for Ovarian Cancer Therapy Open Access

    Nakamura, K; Yoshikawa, N; Mizuno, Y; Ito, M; Tanaka, H; Mizuno, M; Toyokuni, S; Hori, M; Kikkawa, F; Kajiyama, H

    CANCERS   Vol. 13 ( 5 )   2021.3

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  363. Does complete-staging lymphadenectomy improve survival outcomes in stage I endometrioid epithelial ovarian carcinoma? A multi-institutional retrospective study with propensity score-weighted analysis Open Access

    Yoshihara, M; Tamauchi, S; Iyoshi, S; Kitami, K; Uno, K; Tano, S; Matsui, S; Kajiyama, H

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 51 ( 3 ) page: 387 - 392   2021.3

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  364. Ovarian Cancer-Associated Mesothelial Cells: Transdifferentiation to Minions of Cancer and Orchestrate Developing Peritoneal Dissemination Open Access

    Mogi, K; Yoshihara, M; Iyoshi, S; Kitami, K; Uno, K; Tano, S; Koya, Y; Sugiyama, M; Yamakita, Y; Nawa, A; Tomita, H; Kajiyama, H

    CANCERS   Vol. 13 ( 6 )   2021.3

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  365. Expression of the chrXq27.3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance Open Access

    Yoshida, K; Yokoi, A; Sugiyama, M; Oda, S; Kitami, K; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Suzuki, S; Kikkawa, F; Yokoi, T; Kajiyama, H

    ONCOGENE   Vol. 40 ( 7 ) page: 1255 - 1268   2021.2

  366. Extracellular miRNAs as Predictive Biomarkers for Glypican-3-Derived Peptide Vaccine Therapy Response in Ovarian Clear Cell Carcinoma Open Access

    Ukai, M; Yokoi, A; Yoshida, K; Suzuki, S; Shibata, K; Kikkawa, F; Nakatsura, T; Kajiyama, H

    CANCERS   Vol. 13 ( 3 )   2021.2

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  367. Active vitamin D inhibits mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer

    Kitami, K; Yoshihara, M; Sugiyama, M; Koya, Y; Iyoshi, S; Uno, K; Mogi, K; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 112   page: 351 - 351   2021.2

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  368. Anti-tumor effect of 9-oxo-10,12-ODA on human cervical cancer cells

    Koya, Y; Sugiyama, M; Yoshihara, M; Shibata, K; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 112   page: 826 - 826   2021.2

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  369. Establishment of a patient-derived xenograft model and cell line of malignant transformation of mature cystic teratoma of the ovary

    Tamauchi, S; Suzuki, S; Xuboya, C; Yoshihara, M; Yoshida, K; Ikeda, Y; Yoshikawa, N; Kajiyama, H; Kikkawa, F

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 2 ) page: 713 - 719   2021.2

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  370. Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage

    Owaki, T; Imai, K; Miki, R; Niwa, Y; Kotani, T; Nakano-Kobayashi, T; Ushida, T; Kajiyama, H

    CYTOKINE   Vol. 138   page: 155406   2021.2

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  371. Luteolin suppresses Ovarian Cancer progression via decrease the expression of VRK1

    Chang, XY; Kajiyama, H; Yoshikawa, N; Yokoi, A; Tamauchi, S; Yoshihara, M

    CANCER SCIENCE   Vol. 112   page: 770 - 770   2021.2

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    Web of Science

  372. Intra-tumoral polarity induced by Notch signaling can be a novel therapeutic target for advanced ovarian cancer

    Yoshihara, M; Sugiyama, M; Koya, Y; Iyoshi, S; Kitami, K; Uno, K; Mogi, K; Tano, S; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 112   page: 363 - 363   2021.2

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    Web of Science

  373. How do peritoneal mesothelial cells on adipose tissue attract ovarian cancer cells?

    Mogi, K; Yoshihara, M; Kitami, K; Iyoshi, S; Uno, K; Tano, S; Sugiyama, M; Koya, Y; Tamauchi, S; Yokoi, A; Yoshikawa, N; Nawa, A; Kajiyama, H

    CANCER SCIENCE   Vol. 112   page: 341 - 341   2021.2

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  374. The role of chrXq27.3 miRNA cluster in advanced ovarian clear cell carcinoma

    Yoshida, K; Yokoi, A; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Nishino, K; Niimi, K; Kikkawa, F; Kajiyama, H

    CANCER SCIENCE   Vol. 112   page: 291 - 291   2021.2

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    Web of Science

  375. Visualization of platinum resistance through mapping trace elements

    Uno, K; Yoshikawa, N; Yoshihara, M; Tazaki, K; Kato, M; Kitami, K; Iyoshi, S; Tamauchi, S; Sugiyama, M; Koya, Y; Kajiyama, H

    CANCER SCIENCE   Vol. 112   page: 906 - 906   2021.2

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  376. Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy Open Access

    Nakamura, N; Ushida, T; Nakatochi, M; Kobayashi, Y; Moriyama, Y; Imai, K; Nakano-Kobayashi, T; Hayakawa, M; Kajiyama, H; Kikkawa, F; Kotani, T

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 1729   2021.1

  377. A uterine pseudotumor of immunoglobulinG4-related disease

    Senda, Y; Ikeda, Y; Tamauchi, S; Yoshikawa, N; Kikkawa, F; Kajiyama, H

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 1 ) page: 430 - 435   2021.1

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  378. The Prognostic Significance of Peritumoral Lymphocytes' Band-like Structure in Type II Endometrial Cancer Open Access

    Shimizu, Y; Suzuki, S; Ukai, M; Hattori, S; Yoshikawa, N; Kajiyama, H

    ANTICANCER RESEARCH   Vol. 41 ( 1 ) page: 249 - 258   2021.1

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  379. Cancer Treatments Using Low-Temperature Plasma

    Tanaka, H; Mizuno, M; Ishikawa, K; Toyokuni, S; Kajiyama, H; Kikkawa, F; Hori, M

    CURRENT MEDICINAL CHEMISTRY   Vol. 28 ( 41 ) page: 8549 - 8558   2021

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  380. [Promotion of Equal Access to Medical Services for Children, Adolescent and Young Adult(CAYA)Cancer Patients with Reproductive Problems-A Nationwide Expansion of the Regional Oncofertility Network in Japan].

    Takenaka M, Furui T, Takae S, Sugishita Y, Kawahara T, Shigematsu K, Kimura F, Horie A, Hara T, Kato M, Nishiyama H, Suzuki T, Miyachi M, Kanenishi K, Kubo K, Nakayama S, Kajiyama H, Takai Y, Suzuki N

    Gan to kagaku ryoho. Cancer & chemotherapy   Vol. 47 ( 12 ) page: 1691 - 1696   2020.12

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  381. Efficacy of 5-aminolevulinic acid and LED photodynamic therapy in cervical intraepithelial neoplasia: A clinical trial

    Mizuno, M; Mitsui, H; Kajiyama, H; Teshigawara, T; Inoue, K; Takahashi, K; Ishii, T; Ishizuka, M; Nakajima, M; Kikkawa, F

    PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY   Vol. 32   page: 102004   2020.12

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  382. Microphthalmia-Associated Transcription Factor-Dependent Melanoma Cell Adhesion Molecule Activation Promotes Peritoneal Metastasis of Ovarian Cancer Open Access

    Kitami, K; Yoshihara, M; Koya, Y; Sugiyama, M; Iyoshi, S; Uno, K; Mogi, K; Tano, S; Fujimoto, H; Nawa, A; Kikkawa, F; Kajiyama, H

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 21 ( 24 )   2020.12

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  383. Sarcopenia as a Predictor of Survival Among Patients With Organ Metastatic Cervical Cancer

    Yoshikawa, N; Shirakawa, A; Yoshida, K; Tamauchi, S; Suzuki, S; Kikkawa, F; Kajiyama, H

    NUTRITION IN CLINICAL PRACTICE   Vol. 35 ( 6 ) page: 1041 - 1046   2020.12

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  384. Does uterine preservation affect survival outcomes of patients with stage I ovarian sex cord-stromal cell tumours? A multi-institutional study

    Yoshihara, M; Tamauchi, S; Iyoshi, S; Kitami, K; Uno, K; Yoshikawa, N; Ikeda, Y; Kawai, M; Nagasaka, T; Kajiyama, H

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 254   page: 52 - 56   2020.11

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  385. Establishment and characterization of cell lines from human endometrial epithelial and mesenchymal cells from patients with endometriosis.

    Muraoka A, Osuka S, Kiyono T, Suzuki M, Yokoi A, Murase T, Nishino K, Niimi K, Nakamura T, Goto M, Kajiyama H, Kondo Y, Kikkawa F

    F&S science   Vol. 1 ( 2 ) page: 195 - 205   2020.11

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    Language:English  

    DOI: 10.1016/j.xfss.2020.09.001

    PubMed

  386. Adjusted multiple gases in the plasma flow induce differential antitumor potentials of plasma-activated solutions

    Nakamura, K; Yoshikawa, N; Yoshihara, M; Ikeda, Y; Higashida, A; Niwa, A; Jindo, T; Tanaka, H; Ishikawa, K; Mizuno, M; Toyokuni, S; Hori, M; Kikkawa, F; Kajiyama, H

    PLASMA PROCESSES AND POLYMERS   Vol. 17 ( 10 )   2020.10

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    DOI: 10.1002/ppap.201900259

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  387. Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production

    Kawata, R; Oda, S; Koya, Y; Kajiyama, H; Yokoi, T

    TOXICOLOGY   Vol. 443   page: 152544   2020.10

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  388. Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice Open Access

    Hayashi, S; Nakamura, T; Motooka, Y; Ito, F; Jiang, L; Akatsuka, S; Iwase, A; Kajiyama, H; Kikkawa, F; Toyokuni, S

    REDOX BIOLOGY   Vol. 37   page: 101726   2020.10

  389. Long non-coding RNA: A recently accentuated molecule in chemoresistance in cancer

    Peng, Y; Tang, DH; Zhao, M; Kajiyama, H; Kikkawa, F; Kondo, Y

    CANCER AND METASTASIS REVIEWS   Vol. 39 ( 3 ) page: 825 - 835   2020.9

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  390. Follicular dendritic cell sarcoma of the uterine cervix: a case report Open Access

    Nakamura, T; Yoshihara, M; Tamauchi, S; Kajiyama, H; Kikkawa, F

    BMC WOMENS HEALTH   Vol. 20 ( 1 ) page: 182   2020.8

  391. Survival after Anticancer Treatment of Terminally Ill Patients with Ovarian Carcinoma

    Kajiyama, H; Suzuki, S; Shimbo, A; Utsumi, F; Yoshikawa, N; Kikkawa, F

    JOURNAL OF PALLIATIVE MEDICINE   Vol. 23 ( 8 ) page: 1060 - 1065   2020.8

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  392. Impact of uterus-preserving surgery on Stage I primary mucinous epithelial ovarian carcinoma: A multi-institutional study with propensity score-weighted analysis

    Yoshihara, M; Kajiyama, H; Tamauchi, S; Iyoshi, S; Yokoi, A; Suzuki, S; Kawai, M; Nagasaka, T; Takahashi, K; Matsui, S; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS   Vol. 150 ( 2 ) page: 177 - 183   2020.8

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  393. Non-thermal plasma-activated lactate solution kills U251SP glioblastoma cells in an innate reductive manner with altered metabolism

    Ishikawa, K; Hosoi, Y; Tanaka, H; Jiang, L; Toyokuni, S; Nakamura, K; Kajiyama, H; Kikkawa, F; Mizuno, M; Hori, M

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 688   page: 108414   2020.7

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  394. Filopodia play an important role in the trans-mesothelial migration of ovarian cancer cells Open Access

    Yoshihara, M; Yamakita, Y; Kajiyama, H; Senga, T; Koya, Y; Yamashita, M; Nawa, A; Kikkawa, F

    EXPERIMENTAL CELL RESEARCH   Vol. 392 ( 2 ) page: 112011   2020.7

  395. Exploration of small RNA biomarkers for testicular injury in the serum exosomes of rats

    Kawata, R; Kagawa, T; Koya, Y; Kajiyama, H; Oda, S; Yokoi, T

    TOXICOLOGY   Vol. 440   page: 152490   2020.7

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  396. The impact of systematic retroperitoneal lymphadenectomy on long-term oncologic outcome of women with advanced ovarian clear-cell carcinoma Open Access

    Kajiyama, H; Suzuki, S; Yoshikawa, N; Tamauchi, S; Shibata, K; Kikkawa, F

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 31 ( 4 ) page: e47   2020.7

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  397. The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study Open Access

    Yamamoto, E; Minh, TD; Sekiya, Y; Tamakoshi, K; Nguyen, XP; Nishino, K; Kotani, KT; Kajiyama, H; Shibata, K; Le, QT; Kikkawa, F

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 183 - 191   2020.5

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  398. Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments

    Sassa, N; Yokoyama, Y; Nishida, Y; Yamada, S; Uchida, H; Kajiyama, H; Nagino, M; Kodera, Y; Gotoh, M

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 5 ) page: 929 - 936   2020.5

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  399. Folate-appended cyclodextrin carrier targets ovarian cancer cells expressing the proton-coupled folate transporter Open Access

    Saito, S; Koya, Y; Kajiyama, H; Yamashita, M; Kikkawa, F; Nawa, A

    CANCER SCIENCE   Vol. 111 ( 5 ) page: 1794 - 1804   2020.5

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  400. Pegylated Liposomal Doxorubicin/Oxaliplatin Chemotherapy Can Overcome Cisplatin Resistance in Spectrin αII-Overexpressing Ovarian Carcinoma Open Access

    Maeda, O; Kajiyama, H; Shibata, K; Nakamura, S; Kikkawa, F

    ANTICANCER RESEARCH   Vol. 40 ( 5 ) page: 2497 - 2507   2020.5

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  401. Is cell block technique useful to predict histological type in patients with ovarian mass and/or body cavity fluids? Open Access

    Masekii, Z; Kajiyama, H; Nishikawa, E; Satake, T; Misawa, T; Kikkawa, F

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 225 - 235   2020.5

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  402. The Preoperative Prognostic Nutritional Index for the Prediction of Outcomes in Patients with Early-Stage Ovarian Clear Cell Carcinoma Open Access

    Yoshikawa, N; Yoshida, K; Tamauchi, S; Ikeda, Y; Nishino, K; Niimi, K; Suzuki, S; Kikkawa, F; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 7135   2020.4

  403. The Therapeutic Effects of Goreisan, a Traditional Japanese Herbal Medicine, on Lower-Limb Lymphedema after Lymphadenectomy in Gynecologic Malignancies: A Case Series Study Open Access

    Yoshikawa, N; Kajiyama, H; Otsuka, N; Tamauchi, S; Ikeda, Y; Nishino, K; Niimi, K; Suzuki, S; Utsumi, F; Shibata, K; Kikkawa, F

    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE   Vol. 2020   page: 6298293   2020.4

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  404. Ovarian cancer-associated mesothelial cells induce acquired platinum-resistance in peritoneal metastasis <i>via</i> the FN1/Akt signaling pathway Open Access

    Yoshihara, M; Kajiyama, H; Yokoi, A; Sugiyama, M; Koya, Y; Yamakita, Y; Liu, WT; Nakamura, K; Moriyama, Y; Yasui, H; Suzuki, S; Yamamoto, Y; Ricciardelli, C; Nawa, A; Shibata, K; Kikkawa, F

    INTERNATIONAL JOURNAL OF CANCER   Vol. 146 ( 8 ) page: 2268 - 2280   2020.4

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  405. How do doctors choose treatment for older gynecological cancer patients? A Japanese Gynecologic Oncology Group survey of gynecologic oncologists

    Yamamoto, M; Yoshida, Y; Itani, Y; Sato, S; Futagami, M; Sakai, H; Kajiyama, H; Ura, MF; Aoki, Y

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 4 ) page: 741 - 745   2020.4

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  406. Is standard radical surgery necessary for elderly patients with early-stage epithelial ovarian carcinoma? ∼Propensity score matched analysis∼ Open Access

    Kajiyama, H; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Niimi, K; Suzuki, S; Shibata, K; Kikkawa, F

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 50 ( 4 ) page: 411 - 418   2020.4

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  407. Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology

    Naito, Y; Mishima, S; Akagi, K; Igarashi, A; Ikeda, M; Okano, S; Kato, S; Takano, T; Tsuchihara, K; Terashima, K; Nishihara, H; Nishiyama, H; Hiyama, E; Hirasawa, A; Hosoi, H; Maeda, O; Yatabe, Y; Okamoto, W; Ono, S; Kajiyama, H; Nagashima, F; Hatanaka, Y; Miyachi, M; Kodera, Y; Yoshino, T; Taniguchi, H

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 3 ) page: 403 - 417   2020.3

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  408. CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway

    Yasui, H; Kajiyama, H; Tamauchi, S; Suzuki, S; Peng, Y; Yoshikawa, N; Sugiyama, M; Nakamura, K; Kikkawa, F

    CLINICAL & EXPERIMENTAL METASTASIS   Vol. 37 ( 1 ) page: 145 - 158   2020.2

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  409. Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis Open Access

    Yoshihara, M; Kajiyama, H; Tamauchi, S; Iyoshi, S; Yokoi, A; Suzuki, S; Kawai, M; Nagasaka, T; Takahashi, K; Matsui, S; Kikkawa, F

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 50 ( 2 ) page: 145 - 151   2020.2

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  410. The role of additional hysterectomy after concurrent chemoradiation for patients with locally advanced cervical cancer

    Yoshida, K; Kajiyama, H; Yoshihara, M; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Suzuki, S; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 2 ) page: 384 - 390   2020.2

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  411. Plasma-activated medium promotes autophagic cell death along with alteration of the mTOR pathway Open Access

    Yoshikawa, N; Liu, WT; Nakamura, K; Yoshida, K; Ikeda, Y; Tanaka, H; Mizuno, M; Toyokuni, S; Hori, M; Kikkawa, F; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 1614   2020.1

  412. Clinical Significance of Ubiquitin-associated Protein 2-like in Patients With Uterine Cervical Cancer Open Access

    Yoshida, K; Kajiyama, H; Inami, E; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Utsumi, F; Niimi, K; Suzuki, S; Shibata, K; Nawa, A; Kikkawa, F

    IN VIVO   Vol. 34 ( 1 ) page: 109 - 116   2020.1

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  413. Complete Response of Recurrent Small Cell Carcinoma of the Uterine Cervix to Paclitaxel, Carboplatin, and Bevacizumab Combination Therapy. Open Access

    Nakao Y, Tamauchi S, Yoshikawa N, Suzuki S, Kajiyama H, Kikkawa F

    Case reports in oncology   Vol. 13 ( 1 ) page: 373 - 378   2020.1

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  414. Impact of age on clinicopathological features and survival of epithelial ovarian neoplasms in reproductive age Open Access

    Hanatani, M; Yoshikawa, N; Yoshida, K; Tamauchi, S; Ikeda, Y; Nishino, K; Niimi, K; Suzuki, S; Kawai, M; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 187 - 194   2020.1

  415. The efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide and actinomycin D in patients with choriocarcinoma and high-risk gestational trophoblastic neoplasia

    Sato, S; Yamamoto, E; Niimi, K; Ino, K; Nishino, K; Suzuki, S; Kotani, T; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 203 - 209   2020.1

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  416. Fertility-sparing surgery and oncologic outcome among patients with early-stage ovarian cancer ∼propensity score- matched analysis∼ Open Access

    Kajiyama, H; Suzuki, S; Yoshikawa, N; Kawai, M; Mizuno, K; Yamamuro, O; Nagasaka, T; Shibata, K; Kikkawa, F

    BMC CANCER   Vol. 19 ( 1 ) page: 1235   2019.12

  417. Unique miRNA profiling of squamous cell carcinoma arising from ovarian mature teratoma: comprehensive miRNA sequence analysis of its molecular background Open Access

    Yoshida, K; Yokoi, A; Kagawa, T; Oda, S; Hattori, S; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Utsumi, F; Niimi, K; Suzuki, S; Shibata, K; Kajiyama, H; Yokoi, T; Kikkawa, F

    CARCINOGENESIS   Vol. 40 ( 12 ) page: 1435 - 1444   2019.12

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  418. Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma Open Access

    Shimbo, A; Kajiyama, H; Tamauchi, S; Yoshikawa, N; Ikeda, Y; Nishino, K; Suzuki, S; Niimi, K; Sakata, J; Kikkawa, F

    ONCOLOGY REPORTS   Vol. 42 ( 6 ) page: 2323 - 2332   2019.12

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  419. The usefulness of bevacizumab for relief from symptomatic malignant ascites in patients with heavily treated recurrent ovarian cancer

    Shimizu, Y; Kajiyama, H; Yoshida, K; Tamauchi, S; Nakanishi, T; Kikkawa, F

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 45 ( 12 ) page: 2435 - 2439   2019.12

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  420. COMPREHENSIVE MIRNA SEQUENCING OF SQUAMOUS CELL CARCINOMA ARISING FROM OVARIAN MATURE TERATOMA

    Yoshida, K; Yokoi, A; Tamauchi, S; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Suzuki, S; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29   page: A544 - A545   2019.11

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  421. Prognostic value of neutrophil-to-lymphocyte ratio in early-stage ovarian clear-cell carcinoma Open Access

    Yoshida, K; Yoshikawa, N; Shirakawa, A; Niimi, K; Suzuki, S; Kajiyama, H; Kikkawa, F

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 30 ( 6 ) page: e85   2019.11

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  422. Prognostic factors and effects of fertility-sparing surgery in women of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis Open Access

    Yoshihara, M; Kajiyama, H; Tamauchi, S; Suzuki, S; Takahashi, K; Matsui, S; Kikkawa, F

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 30 ( 6 ) page: e102   2019.11

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  423. REDUCED RESPONSE TO CONTROLLED OVARIAN STIMULATION AFTER RADICAL TRACHELECTOMY

    Tamauchi, S; Kajiyama, H; Osuka, S; Moriyama, Y; Yoshihara, M; Iyoshi, S; Yoshida, K; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Suzuki, S; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29   page: A269 - A270   2019.11

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  424. Fertility-Sparing surgery for young women with ovarian endometrioid carcinoma: a multicenteric comparative study using inverse probability of treatment weighting. Open Access

    Kajiyama H, Yoshihara M, Tamauchi S, Yoshikawa N, Suzuki S, Kikkawa F

    European journal of obstetrics & gynecology and reproductive biology: X   Vol. 4   page: 100071   2019.10

  425. Relationship between preexisting mental disorders and prognosis of gynecologic cancers: A case-control study

    Tamauchi, S; Kajiyama, H; Moriyama, Y; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Niimi, K; Suzuki, S; Kikkawa, F

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 45 ( 10 ) page: 2082 - 2087   2019.10

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  426. Oxidative stress-dependent and -independent death of glioblastoma cells induced by non-thermal plasma-exposed solutions Open Access

    Tanaka, H; Mizuno, M; Katsumata, Y; Ishikawa, K; Kondo, H; Hashizume, H; Okazaki, Y; Toyokuni, S; Nakamura, K; Yoshikawa, N; Kajiyama, H; Kikkawa, F; Hori, M

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 13657   2019.9

  427. Long-term oncologic outcome and its prognostic indicators in reproductive-age women with ovarian clear-cell carcinoma

    Kajiyama, H; Suzuki, S; Yoshikawa, N; Niimi, K; Kawai, M; Shibata, K; Kikkawa, F

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 300 ( 3 ) page: 717 - 724   2019.9

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  428. Interleukin-33 expression in ovarian cancer and its possible suppression of peritoneal carcinomatosis Open Access

    Sekiya, A; Suzuki, S; Tanaka, A; Hattori, S; Shimizu, Y; Yoshikawa, N; Koya, Y; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF ONCOLOGY   Vol. 55 ( 3 ) page: 755 - 765   2019.9

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  429. Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma

    Kajiyama, H; Suzuki, S; Utsumi, F; Yoshikawa, N; Nishino, K; Ikeda, Y; Niimi, K; Yamamoto, E; Kawai, M; Shibata, K; Nagasaka, T; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 8 ) page: 950 - 956   2019.8

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  430. Oncologic and reproductive outcomes of cystectomy as a fertility-sparing treatment for early-stage epithelial ovarian cancer

    Kajiyama, H; Suzuki, S; Niimi, K; Tamauchi, S; Kawai, M; Nagasaka, T; Shibata, K; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 7 ) page: 857 - 862   2019.7

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  431. Oncologic outcomes after secondary surgery in recurrent clear-cell carcinoma of the ovary

    Kajiyama, H; Suzuki, S; Yoshikawa, N; Kawai, M; Shibata, K; Nagasaka, T; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29 ( 5 ) page: 910 - 915   2019.6

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  432. Epidemiological overview of metastatic ovarian carcinoma: long-term experience of TOTSG database Open Access

    Kajiyama, H; Suzuki, S; Utsumi, F; Nishino, K; Niimi, K; Mizuno, M; Yoshikawa, N; Kawai, M; Oguchi, H; Mizuno, K; Yamamuro, O; Shibata, K; Nagasaka, T; Kikkawa, F

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page: 193 - 198   2019.5

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  433. Does postoperative prophylactic irradiation of para-aortic lymph nodes reduce the risk of recurrence in uterine cervical cancer with positive pelvic lymph nodes?

    Yoshida, K; Kajiyama, H; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Utsumi, F; Niimi, K; Suzuki, S; Kikkawa, F

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 5 ) page: 567 - 574   2019.5

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  434. Urinary levels of the leukocyte surface molecule CD11b associate with glomerular inflammation in lupus nephritis Open Access

    Kitagawa, A; Tsuboi, N; Yokoe, Y; Katsuno, T; Ikeuchi, H; Kajiyama, H; Endo, N; Sawa, Y; Suwa, J; Sugiyama, Y; Hachiya, A; Mimura, T; Hiromura, K; Maruyama, S

    KIDNEY INTERNATIONAL   Vol. 95 ( 3 ) page: 680 - 692   2019.3

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  435. Endometriosis and cancer

    Kajiyama, H; Suzuki, S; Yoshihara, M; Tamauchi, S; Yoshikawa, N; Niimi, K; Shibata, K; Kikkawa, F

    FREE RADICAL BIOLOGY AND MEDICINE   Vol. 133   page: 186 - 192   2019.3

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  436. Survival impact of capsule status in stage I ovarian mucinous carcinoma-A mulicentric retrospective study

    Kajiyama, H; Suzuki, S; Yoshikawa, N; Kawai, M; Nagasaka, T; Kikkawa, F

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 234   page: 131 - 136   2019.3

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  437. Non-thermal plasma-activated medium modified metabolomic profiles in the glycolysis of U251SP glioblastoma

    Kurake, N; Ishikawa, K; Tanaka, H; Hashizume, H; Nakamura, K; Kajiyama, H; Toyokuni, S; Kikkawa, F; Mizuno, M; Hori, M

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 662   page: 83 - 92   2019.2

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  438. PAI-1 secreted from metastatic ovarian cancer cells triggers the tumor-promoting role of the mesothelium in a feedback loop to accelerate peritoneal dissemination Open Access

    Peng, Y; Kajiyama, H; Yuan, H; Nakamura, K; Yoshihara, M; Yokoi, A; Fujikake, K; Yasui, H; Yoshikawa, N; Suzuki, S; Senga, T; Shibata, K; Kikkawa, F

    CANCER LETTERS   Vol. 442   page: 181 - 192   2019.2

  439. Estrogen producing ovarian fibrosarcoma: A case report Open Access

    Miura, M; Suzuki, S; Shibata, K; Kajiyama, H; Kikkawa, F

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 1 ) page: 171 - 176   2019.2

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  440. Molecular mechanisms of non-thermal plasmainduced effects in cancer cells Open Access

    Tanaka, H; Mizuno, M; Ishikawa, K; Toyokuni, S; Kajiyama, H; Kikkawa, F; Hori, M

    BIOLOGICAL CHEMISTRY   Vol. 400 ( 1 ) page: 87 - 91   2019.1

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  441. The role of extracellular RNAs in ovarian cancer

    Yokoi, A; Yoshioka, Y; Yamamoto, Y; Matsuzaki, J; Kato, T; Kato, K; Kajiyama, H; Kikkawa, F; Ochiya, T

    CANCER SCIENCE   Vol. 109   page: 351 - 351   2018.12

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  442. Cancer-associated mesothelial cells as a potential therapeutic target in epithelial ovarian cancer

    Yoshihara, M; Kajiyama, H; Sugiyama, M; Koya, Y; Ryu, B; Yokoi, A; Yamamoto, Y; Kikkawa, F

    CANCER SCIENCE   Vol. 109   page: 247 - 247   2018.12

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  443. Mesothelial cells create invasion frontier in peritoneal metastasis of epithelial ovarian cancer

    Iyoshi, S; Kajiyama, H; Yoshihara, M; Yamakita, Y; Sugiyama, M; Koya, Y; Ryu, B; Kikkawa, F

    CANCER SCIENCE   Vol. 109   page: 282 - 282   2018.12

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  444. Notch signaling enhances the mutual association with epithelial ovarian cancer and mesothelial cells

    Sugiyama, M; Yoshihara, M; Koya, Y; Yokoi, A; Ryu, B; Kikkawa, F; Kajiyama, H

    CANCER SCIENCE   Vol. 109   page: 864 - 864   2018.12

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  445. MITF contributes to cell migration/invasion in ovarian carcinoma cells

    Koya, Y; Ryu, B; Sugiyama, M; Yoshihara, M; Senga, T; Nawa, A; Kikkawa, F; Kajiyama, H

    CANCER SCIENCE   Vol. 109   page: 503 - 503   2018.12

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  446. Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study Open Access

    Tamauchi, S; Kajiyama, H; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Utsumi, F; Niimi, K; Suzuki, S; Kikkawa, F

    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY   Vol. 219 ( 4 ) page: 385.e1 - 385.e7   2018.10

  447. CANCER-ASSOCIATED MESOTHELIAL CELLS IN PERITONEAL METASTASIS OF EPITHELIAL OVARIAN CANCER AS A NOVEL THERAPEUTIC TARGET: 3D CO-CULTURE MODELS AND MULTI-OMICS ANALYSIS

    Masato, Y; Kajiyama, H; Yoshihiko, Y; Mai, S; Koya, Y; Ryu, B; Akira, Y; Shiro, S; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 187 - 188   2018.9

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  448. EFFECT OF CONCURRENT CHEMO-RADIOTHERAPY ON CLINICAL OUTCOMES IN SMALL CELL CARCINOMA OF THE UTERINE CERVIX

    Ikeda, Y; Kajiyama, H; Yoshida, K; Yoshikawa, N; Nishino, K; Utsumi, F; Niimi, K; Suzuki, S; Kawai, M; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 294 - 294   2018.9

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  449. PROPENSITY SCORE ADJUSTED ANALYSIS OF PROPHYLACTIC IRRADIATION TO PARA-AORTIC LYMPH NODE AFTER RADICAL HYSTERECTOMY FOR UTERINE CERVICAL CANCER.

    Yoshida, K; Yoshihara, M; Ikeda, Y; Yoshikawa, N; Nishino, K; Utumi, F; Niimi, K; Suzuki, S; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 447 - 447   2018.9

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  450. Hematopoietic lineage cell-specific protein 1 (HS1), a hidden player in migration, invasion, and tumor formation, is over-expressed in ovarian carcinoma cells.

    Koya Y, Liu W, Yamakita Y, Senga T, Shibata K, Yamashita M, Nawa A, Kikkawa F, Kajiyama H

    Oncotarget   Vol. 9 ( 66 ) page: 32609 - 32623   2018.8

  451. KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear-cell carcinoma cells Open Access

    Kawai, Y; Shibata, K; Sakata, J; Suzuki, S; Utsumi, F; Niimi, K; Sekiya, R; Senga, T; Kikkawa, F; Kajiyama, H

    ONCOLOGY REPORTS   Vol. 40 ( 1 ) page: 195 - 205   2018.7

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  452. The upregulated expression of vascular endothelial growth factor in surgically treated patients with recurrent/radioresistant cervical cancer of the uterus Open Access

    Yoshida, K; Suzuki, S; Sakata, J; Utsumi, F; Niimi, K; Yoshikawa, N; Nishino, K; Shibata, K; Kikkawa, F; Kajiyama, H

    ONCOLOGY LETTERS   Vol. 16 ( 1 ) page: 515 - 521   2018.7

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  453. Fertility-sparing surgery of malignant transformation arising from mature cystic teratoma of the ovary.

    Yoshikawa N, Teshigawara T, Ikeda Y, Nishino K, Sakata J, Utsumi F, Niimi K, Sekiya R, Suzuki S, Kawai M, Shibata K, Kikkawa F, Kajiyama H

    Oncotarget   Vol. 9 ( 44 ) page: 27564 - 27573   2018.6

  454. Hematopoietic lineage cell-specific protein 1 immunoreactivity indicates an increased risk of poor overall survival in patients with ovarian carcinoma Open Access

    Liu, WT; Kajiyama, H; Shibata, K; Koya, Y; Senga, T; Kikkawa, F

    ONCOLOGY LETTERS   Vol. 15 ( 6 ) page: 9406 - 9412   2018.6

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  455. Dengue fever during pregnancy. Open Access

    Tien Dat T, Kotani T, Yamamoto E, Shibata K, Moriyama Y, Tsuda H, Yamashita M, Kajiyama H, Duc Thien Minh D, Quang Thanh L, Kikkawa F

    Nagoya journal of medical science   Vol. 80 ( 2 ) page: 241 - 247   2018.5

  456. Dengue fever during pregnancy Open Access

    Trinh Tien Dat, Kotani Tomomi, Yamamoto Eiko, Shibata Kiyosumi, Moriyama Yoshinori, Tsuda Hiroyuki, Yamashita Mamoru, Kajiyama Hiroaki, Dien Duc Thien Minh, Le Quang Thanh, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 2 ) page: 241 - 247   2018.5

  457. Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model.

    Ohara Y, Chew SH, Misawa N, Wang S, Somiya D, Nakamura K, Kajiyama H, Kikkawa F, Tsuyuki Y, Jiang L, Yamashita K, Sekido Y, Lipson KE, Toyokuni S

    Oncotarget   Vol. 9 ( 26 ) page: 18494 - 18509   2018.4

  458. Splicing variant of <i>WDFY4</i> augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis

    Kochi, Y; Kamatani, Y; Kondo, Y; Suzuki, A; Kawakami, E; Hiwa, R; Momozawa, Y; Fujimoto, M; Jinnin, M; Tanaka, Y; Kanda, T; Cooper, RG; Chinoy, H; Rothwell, S; Lamb, JA; Vencovsky, J; Mann, H; Ohmura, K; Myouzen, K; Ishigaki, K; Nakashima, R; Hosono, Y; Tsuboi, H; Kawasumi, H; Iwasaki, Y; Kajiyama, H; Horita, T; Ogawa-Momohara, M; Takamura, A; Tsunoda, S; Shimizu, J; Fujio, K; Amano, H; Mimori, A; Kawakami, A; Umehara, H; Takeuchi, T; Sano, H; Muro, Y; Atsumi, T; Mimura, T; Kawaguchi, Y; Mimori, T; Takahashi, A; Kubo, M; Kohsaka, H; Sumida, T; Yamamoto, K

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 77 ( 4 ) page: 602 - 611   2018.4

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  459. Novel potential photodynamic therapy strategy using 5-Aminolevulinic acid for ovarian clear-cell carcinoma

    Teshigawara, T; Mizuno, M; Ishii, T; Kitajima, Y; Utsumi, F; Sakata, J; Kajiyama, H; Shibata, K; Ishizuka, M; Kikkawa, F

    PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY   Vol. 21   page: 121 - 127   2018.3

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  460. Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium

    Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Takeda Keigo, Hashizume Hiroshi, Nakamura Kae, Utsumi Fumi, Kajiyama Hiroaki, Okazaki Yasumasa, Toyokuni Shinya, Akiyama Shinichi, Maruyama Shoichi, Kikkawa Fumitaka, Hori Masaru

    IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES   Vol. 2 ( 2 ) page: 99 - 102   2018.3

  461. Secondary cytoreductive surgery potentially improves the oncological outcomes of patients with recurrent uterine sarcomas.

    Nakamura K, Kajiyama H, Utsumi F, Suzuki S, Niimi K, Sekiya R, Sakata J, Yamamoto E, Shibata K, Kikkawa F

    Molecular and clinical oncology   Vol. 8 ( 3 ) page: 499 - 503   2018.3

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  462. A post-recurrence survival-predicting indicator for cervical cancer from the analysis of 165 patients who developed recurrence.

    Yoshida K, Kajiyama H, Utsumi F, Niimi K, Sakata J, Suzuki S, Shibata K, Kikkawa F

    Molecular and clinical oncology   Vol. 8 ( 2 ) page: 281 - 285   2018.2

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    DOI: 10.3892/mco.2017.1530

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  463. The possible existence of occult metastasis in patients with ovarian clear-cell carcinoma who underwent complete resection without any residual tumours.

    Kajiyama H, Suzuki S, Yoshihara M, Nishino K, Yoshikawa N, Utsumi F, Niimi K, Mizuno M, Kawai M, Oguchi H, Mizuno K, Yamamuro O, Nagasaka T, Shibata K, Kikkawa F

    Oncotarget   Vol. 9 ( 5 ) page: 6298 - 6307   2018.1

  464. A novel mechanism of neovascularization in peritoneal dissemination via cancer-associated mesothelial cells affected by TGF-beta derived from ovarian cancer Open Access

    Fujikake Kayo, Kajiyama Hiroaki, Yoshihara Masato, Nishino Kimihiro, Yoshikawa Nobuhisa, Utsumi Fumi, Suzuki Shiro, Niimi Kaoru, Sakata Jun, Mitsui Hiroko, Shibata Kiyosumi, Senga Takeshi, Kikawa Fumitaka

    ONCOLOGY REPORTS   Vol. 39 ( 1 ) page: 193 - 200   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/or.2017.6104

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  465. Efficacy of medroxyprogesterone acetate treatment and retreatment for atypical endometrial hyperplasia and endometrial cancer

    Tamauchi, S; Kajiyama, H; Utsumi, F; Suzuki, S; Niimi, K; Sakata, J; Mizuno, M; Shibata, K; Kikkawa, F

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 44 ( 1 ) page: 151 - 156   2018.1

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  466. Carcinoma-associated mesothelial cells promote dissemination and platinum resistance in epithelial ovarian cancer.

    Yoshihara, M; Kajiyama, H; Sugiyama, M; Yasui, H; Koya, Y; Yamakita, Y; Ryu, B; Yokoi, A; Yamamoto, Y; Kikkawa, F

    CANCER SCIENCE   Vol. 109   page: 118 - 118   2018.1

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  467. HS1 contributes cell migration/invasion and tumor formation in ovarian carcinoma

    Koya, Y; Liu, WT; Yamakita, Y; Kajiyama, H; Senga, T; Shibata, K; Nawa, A; Kikkawa, F

    CANCER SCIENCE   Vol. 109   page: 308 - 308   2018.1

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  468. Notch signaling enhances the mutual association with epithelial ovarian cancer and mesothelial cells

    Sugiyama, M; Kajiyama, H; Yoshihara, M; Yasui, H; Ryu, B; Koya, Y; Ymakita, Y; Kikkawa, F

    CANCER SCIENCE   Vol. 109   page: 1043 - 1043   2018.1

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  469. Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer Open Access

    Yokoi, A; Yoshioka, Y; Yamamoto, Y; Ishikawa, M; Kato, T; Kiyono, T; Kajiyama, H; Kikkawa, F; Ochiya, T

    CANCER SCIENCE   Vol. 109   page: 29 - 29   2018.1

  470. HS1 immunoreactivity indicates increased risk of poor overall survival in ovarian carcinoma

    Liu, WT; Kajiyama, H; Shibata, K; Koya, Y; Senga, T; Kikkawa, F

    CANCER SCIENCE   Vol. 109   page: 307 - 307   2018.1

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  471. The impact of chemokine in the peritoneal metastatic niche composed of ovarian cancer and peritoneal mesothelial cells

    Yasui, H; Kajiyama, H; Yoshihara, M; Sugiyama, M; Kikkawa, F

    CANCER SCIENCE   Vol. 109   page: 1013 - 1013   2018.1

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  472. Association of serum asymmetric dimethylarginine, homocysteine, and L-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy

    Maruta, E; Wang, JW; Kotani, T; Tsuda, H; Nakano, T; Imai, K; Sumigama, S; Niwa, Y; Mitsui, T; Yoshida, S; Yamashita, M; Nawa, A; Tamakoshi, K; Kajiyama, H; Kikkawa, F

    CLINICA CHIMICA ACTA   Vol. 475   page: 70 - 77   2017.12

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  473. Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells Open Access

    Sakata, J; Utsumi, F; Suzuki, S; Niimi, K; Yamamoto, E; Shibata, K; Senga, T; Kikkawa, F; Kajiyama, H

    ONCOTARGET   Vol. 8 ( 59 ) page: 99482 - 99494   2017.11

  474. ALTERATION OF THE TUMOR MICROENVIRONMENT BY NOTCH SINGNALING ENHANCES THE MUTUAL ASSOCIATION WITH EPITHELIAL OVARIAN CANCER AND MESOTHELIAL CALLS

    Yoshihara M., Kajiyama H., Sugiyama M., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 1726 - 1726   2017.11

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  475. ALTERATION OF THE TUMOR MICROENVIRONMENT BY NOTCH SINGNALING ENHANCES THE MUTUAL ASSOCIATION WITH EPITHELIAL OVARIAN CANCER AND MESOTHELIAL CALLS

    Yoshihara, M; Kajiyama, H; Sugiyama, M; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 563 - 563   2017.11

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  476. ESTABLISHMENT AND CHARACTERISATION OF PATIENT-DERIVED XENOGRAFT MODELS FOR MALIGNANT GYNECOLOGIC TUMORS

    Suzuki, S; Tamauchi, S; Shimizu, Y; Yoshihara, M; Nakamura, K; Yoshikawa, N; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 494 - 494   2017.11

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  477. PRIMA-1MET INDUCES APOPTOSIS THROUGH ACCUMULATION OF INTRACELLULAR REACTIVE OXYGEN SPECIES IRRESPECTIVE OF P53 STATUS AND CHEMO-SENSITIVITY IN EPITHELIAL OVARIAN CANCER CELLS

    Yoshikawa, N; Shimizu, Y; Yoshihara, M; Nakamura, K; Suzuki, S; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 324 - 324   2017.11

  478. PRIMA-1MET INDUCES APOPTOSIS THROUGH ACCUMULATION OF INTRACELLULAR REACTIVE OXYGEN SPECIES IRRESPECTIVE OF P53 STATUS AND CHEMO-SENSITIVITY IN EPITHELIAL OVARIAN CANCER CELLS

    Yoshikawa, N; Shimizu, Y; Yoshihara, M; Nakamura, K; Suzuki, S; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 84 - 84   2017.11

  479. PELVIC EXENTERATION IN PATIENTS WITH RECURRENT OR ADVANCED GYNECOLOGIC MALIGNANCIES

    Takuto, N; Shimizu, Y; Yoshihara, M; Nakamura, K; Yoshikawa, N; Suzuki, S; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 896 - 896   2017.11

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  480. EVALUATING THE LONG TERM PROGNOSTIC FACTOR AND THE ROLE OF CYTOREDUCTION IN THE OVERALL POPULATION OF PATIENTS WITH CLINICAL AND SURGICAL STAGE IV ENDOMETRIAL CARCINOMA

    Shimizu, Y; Kajiyama, H; Suzuki, S; Yoshikawa, N; Nakamura, K; Yoshihara, M; Tamauchi, S; Yoshida, K; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 1213 - 1213   2017.11

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  481. ESTABLISHMENT AND CHARACTERISATION OF PATIENT-DERIVED XENOGRAFT MODELS FOR MALIGNANT GYNECOLOGIC TUMORS

    Suzuki, S; Tamauchi, S; Shimizu, Y; Yoshihara, M; Nakamura, K; Yoshikawa, N; Kajiyama, H; Kikkawa, F

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 1382 - 1382   2017.11

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  482. A combination of circulating miRNAs for the early detection of ovarian cancer Open Access

    Yokoi Akira, Yoshioka Yusuke, Hirakawa Akihiro, Yamamoto Yusuke, Ishikawa Mitsuya, Ikeda Shun-ichi, Kato Tomoyasu, Niimi Kaoru, Kajiyama Hiroaki, Kikkawa Fumitaka, Ochiya Takahiro

    ONCOTARGET   Vol. 8 ( 52 ) page: 89811 - 89823   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.20688

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    Web of Science

    PubMed

  483. Crystallization of calcium oxalate dihydrate in a buffered calcium-containing glucose solution by irradiation with non-equilibrium atmospheric pressure plasma

    Kurake, N; Tanaka, H; Ishikawa, K; Nakamura, K; Kajiyama, H; Kikkawa, F; Mizuno, M; Ikehara, Y; Hori, M

    JOURNAL OF APPLIED PHYSICS   Vol. 122 ( 14 )   2017.10

  484. Impact of positive ZEB1 expression in patients with epithelial ovarian carcinoma as an oncologic outcome-predicting indicator Open Access

    Sakata, J; Kajiyama, H; Suzuki, S; Utsumi, F; Niimi, K; Sekiya, R; Shibata, K; Senga, T; Kikkawa, F

    ONCOLOGY LETTERS   Vol. 14 ( 4 ) page: 4287 - 4293   2017.10

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  485. Establishment and characterization of cell lines derived from complete hydatidiform mole Open Access

    Yamamoto, E; Niimi, K; Kiyono, T; Yamamoto, T; Nishino, K; Nakamura, K; Kotani, T; Kajiyama, H; Shibata, K; Kikkawa, F

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   Vol. 40 ( 3 ) page: 614 - 622   2017.9

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  486. Novel Intraperitoneal Treatment With Non-Thermal Plasma-Activated Medium Inhibits Metastatic Potential of Ovarian Cancer Cells Open Access

    Nakamura, K; Peng, Y; Utsumi, F; Tanaka, H; Mizuno, M; Toyokuni, S; Hori, M; Kikkawa, F; Kajiyama, H

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 6085   2017.7

  487. Intraperitoneal Administration of Plasma-Activated Medium: Proposal of a Novel Treatment Option for Peritoneal Metastasis From Gastric Cancer

    Takeda, S; Yamada, S; Hattori, N; Nakamura, K; Tanaka, H; Kajiyama, H; Kanda, M; Kobayashi, D; Tanaka, C; Fujii, T; Fujiwara, M; Mizuno, M; Hori, M; Kodera, Y

    ANNALS OF SURGICAL ONCOLOGY   Vol. 24 ( 5 ) page: 1188 - 1194   2017.5

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  488. Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer Open Access

    Miyauchi, R; Itoh, Y; Kawamura, M; Hirakawa, A; Shibata, K; Kajiyama, H; Nakahara, R; Kubota, S; Ito, J; Okada, T; Kikkawa, F; Naganawa, S

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page: 211 - 220   2017.5

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  489. Effects of •OH and •NO radicals in the aqueous phase on H<sub>2</sub>O<sub>2</sub> and NO<sub>2</sub><SUP>-</SUP> generated in plasma-activated medium

    Kurake, N; Tanaka, H; Ishikawa, K; Takeda, K; Hashizume, H; Nakamura, K; Kajiyama, H; Kondo, T; Kikkawa, F; Mizuno, M; Hori, M

    JOURNAL OF PHYSICS D-APPLIED PHYSICS   Vol. 50 ( 15 )   2017.3

  490. Malignant extracellular vesicles carrying <i>MMP1</i> mRNA facilitate peritoneal dissemination in ovarian cancer Open Access

    Yokoi, A; Yoshioka, Y; Yamamoto, Y; Ishikawa, M; Ikeda, S; Kato, T; Kiyono, T; Takeshita, F; Kajiyama, H; Kikkawa, F; Ochiya, T

    NATURE COMMUNICATIONS   Vol. 8   page: 14470   2017.3

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  491. Clinical significance and predicting indicators of post-cancer-treatment survival in terminally ill patients with ovarian cancer

    Utsumi, F; Kajiyama, H; Niimi, K; Sekiya, R; Sakata, J; Suzuki, S; Shibata, K; Mizuno, M; Kikkawa, F

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 43 ( 2 ) page: 365 - 370   2017.2

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  492. Future perspective of strategic non-thermal plasma therapy for cancer treatment Open Access

    Kajiyama, H; Utsumi, F; Nakamura, K; Tanaka, H; Toyokuni, S; Hori, M; Kikkawa, F

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 60 ( 1 ) page: 33 - 38   2017.1

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  493. c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling Open Access

    Sekiya, Y; Yamamoto, E; Niimi, K; Nishino, K; Nakamura, K; Kotani, T; Kajiyama, H; Shibata, K; Kikkawa, F

    ONCOLOGY   Vol. 92 ( 5 ) page: 299 - 310   2017

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  494. A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age. Reviewed

    Kajiyama H, Mizuno M, Shibata K, Umezu T, Suzuki S, Yamamoto E, Mitsui H, Sekiya R, Niimi K, Kawai M, Nagasaka T, Kikkawa F.

    Int J Clin Oncol.   Vol. 19 ( 5 ) page: 921-7   2014.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-013-0645-3

  495. Oncologic outcome after recurrence in patients with stage I epithelial ovarian cancer: are clear-cell and mucinous histological types a different entities? Reviewed

    Kajiyama H, Mizuno M, Shibata K, Umezu T, Suzuki S, Yamamoto E, Mitsui H, Sekiya R, Niimi K, Kawai M, Nagasaka T, Kikkawa F.

    Eur J Obstet Gynecol Reprod Biol.   Vol. 181   page: 305-10   2014.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejogrb.2014.07.046

  496. PLAGL2 regulates actin cytoskeletal architecture and cell migration. Reviewed

    Sekiya R, Maeda M, Yuan H, Asano E, Hyodo T, Hasegawa H, Ito S, Shibata K, Hamaguchi M, Kikkawa F, Kajiyama H, Senga T.

    Carcinogenesis.     2014.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/carcin/bgu081.

  497. Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells. Reviewed

    Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells.

    Mol Cancer Ther.   Vol. 13 ( 8 ) page: 2081-91   2014.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/1535-7163.MCT-14-0135

  498. Selective cytotoxicity of indirect nonequilibrium atmospheric pressure plasma against ovarian clear-cell carcinoma. Reviewed Open Access

    Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Hori M, Kikkawa F.

    Springerplus.     page: 10.1186/2193-1801-3-398   2014.7

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    DOI: 10.1186/2193-1801-3-398

    Open Access

  499. Recurrence-predicting prognostic factors for patients with early-stage epithelial ovarian cancer undergoing fertility-sparing surgery: a multi-institutional study. Reviewed

    Kajiyama H, Mizuno M, Shibata K, Yamamoto E, Kawai M, Nagasaka T, Kikkawa F.

    Eur J Obstet Gynecol Reprod Biol.     page: 10.1016/j.ejogrb.2014.01.014.   2014.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ejogrb.2014.01.014

  500. Survival benefit of taxane plus platinum in recurrent ovarian cancer with non-clear cell, non-mucinous histology. Reviewed

    Kajiyama H, Shibata K, Mizuno M, Umezu T, Suzuki S, Sekiya R, Niimi K, Mitsui H, Yamamoto E, Kawai M, Nagasaka T, Kikkawa F.

    J Gynecol Oncol.   Vol. 25 ( 1 ) page: 43-50   2014.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3802/jgo.2014.25.1.43

  501. Is there any association between where patients spend the end of life and survival after anticancer treatment for gynecologic malignancy? Reviewed

    Kajiyama H, Utsumi F, Higashi M, Sakata J, Sekiya R, Mizuno M, Umezu T, Suzuki S, Yamamoto E, Mitsui H, Niimi K, Shibata K, Kikkawa F.

    J Palliat Med.   Vol. 17 ( 3 ) page: 325-30   2014.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/jpm.2013.0366

  502. Effect of indirect nonequilibrium atmospheric pressure plasma on anti-proliferative activity against chronic chemo-resistant ovarian cancer cells in vitro and in vivo. Reviewed Open Access

    Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Mizuno M, Ishikawa K, Kondo H, Kano H, Hori M, Kikkawa F.

    PLoS One.     page: 10.1371/journal.pone.0081576.   2013.12

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    DOI: 10.1371/journal.pone.0081576

    Open Access

  503. Long-term clinical outcome of patients with recurrent epithelial ovarian carcinoma: is it the same for each histological type? Reviewed

      Vol. 22 ( 3 ) page: 394-9   2012.3

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  504. Postrecurrent oncologic outcome of patients with ovarian clear cell carcinoma. Reviewed

    Kajiyama H, Shibata K, Mizuno M, Yamamoto E, Fujiwara S, Umezu T, Suzuki S, Nakanishi T, Nagasaka T, Kikkawa F.

    Int J Gynecol Cancer.     page: 10.1097/IGC.0b013e3182540145.   2012

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    DOI: 10.1097/IGC.0b013e3182540145.

  505. Expression of Twist enhances risk of poor oncologic outcome in patients with stage Ib to II cervical carcinoma with lymphovascular space involvement. Reviewed

        page: doi:pii: S0046-8177(12)00190-6   2012

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    DOI: doi:pii: S0046-8177(12)00190-6

  506. Long-term survival of young women receiving fertility-sparing surgery for ovarian cancer in comparison with those undergoing radical surgery. Reviewed

    Kajiyama H, Shibata K, Mizuno M, Umezu T, Suzuki S, Nawa A, Kawai M, Nagasaka T, Kikkawa F.

    Br J Cancer   Vol. 105 ( 9 ) page: 1288-94   2011.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bjc.2011.394

  507. *Fertility-sparing surgery in young women with invasive epithelial ovarian cancer. Reviewed

    Kajiyama H, Shibata K, Suzuki S, Ino K, Nawa A, Kawai M, Nagasaka T, Kikkawa F.

    Eur J Surg Oncol. 2010   Vol. in press   2010

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    DOI: 10.1016/j.ejso.2010.01.005

  508. Fertility-sparing surgery in young women with invasive epithelial ovarian cancer. Reviewed

    Kajiyama H, Shibata K, Suzuki S, Ino K, Nawa A, Kawai M, Nagasaka T, KikkawaF.

    Eur J Surg Oncol.   Vol. 36 ( 4 ) page: 404-8   2010

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    DOI: 10.1016/j.ejso.2010.01.005

  509. The expression ofdipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells. Reviewed

    Kajiyama H, Shibata K, Ino K, Mizutani S, Nawa A, Kikkawa F

    Cancer Sci.   Vol. 101 ( 2 ) page: 347-54   2010

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  510. The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells. Reviewed

    Kajiyama H, Shibata K, Ino K, Mizutani S, Nawa A, Kikkawa F.

    Cancer Sci. 2009   Vol. in press   2009

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    DOI: 10.1111/j.1349-7006.2009.01378.x

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. 上皮間葉転換に基づく細胞膜型ペプチド分解酵素を分子標的とした卵巣癌腹膜転移の抑制

    2006

KAKENHI (Grants-in-Aid for Scientific Research) 23

  1. メタボリックリプログラムによる腫瘍関連腹膜線維化を標的とした卵巣癌の治療戦略開発

    Grant number:26K02541  2026.4 - 2029.3

    科学研究費助成事業  基盤研究(B)

    梶山 広明, 吉原 雅人, 佐藤 綾人, 榎本 篤, 富田 弘之, 茂木 一将, 伊吉 祥平

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    Authorship:Principal investigator 

    Grant amount:\24830000 ( Direct Cost: \19100000 、 Indirect Cost:\5730000 )

    腹膜播種を伴う進行再発卵巣癌に対する有効な治療法は未だに確立されておらず、腫瘍の病勢を制御することで難治性を打破する新たな治療戦略が期待される。研究代表者らはこれまで、腹膜播種微小環境を構築する癌関連中皮細胞(CAMs)を同定し、癌細胞とCAMsとの細胞間クロストークにおける線維化の重要性を明らかにしてきた。本課題では、卵巣癌-CAMs間クロストークによって生じる腫瘍関連腹膜線維化において、CAMsの代謝変動に着目し、分子機構を解明し治療標的化することを目指す。国内最大級のケミカルライブラリーを用いることで、メタボリックリプログラムによる難治性卵巣癌腹膜播種に対する新規治療戦略の開発を試みる。

  2. 多層オミクス解析による卵巣がん腹腔内エクソソーム空間的多様性の探求

    Grant number:24K22163  2024.6 - 2027.3

    科学研究費助成事業  挑戦的研究(萌芽)

    梶山 広明, 横井 暁, 吉田 康将

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    Authorship:Principal investigator 

    Grant amount:\6500000 ( Direct Cost: \5000000 、 Indirect Cost:\1500000 )

    本研究で提案するEVシートは、EVを回収できるような特殊製法を取り入れており、それゆえに他には類を見ない。これまでサンプリングが困難であった微量体液(唾液、涙液、生理的腹水)からもEVが回収でき、EV研究領域に革新をもたらす技術である。例えば、腹腔内環境については、EVシートを用いることにより、腹水という概念は大きく変わることになる。EVシートにより腹腔内における位置情報が付加されることにより、腹水は、従来の『均一な液体』ではなく、『腹水は臓器表面に応じて空間的に多様な液体』という新しい概念に一新されることになり、卵巣がん進展の新たなメカニズムの解明に挑戦する。
    細胞外小胞(extracellular vesicles: EV)は、細胞間相互作用を仲介する情報伝達因子として、がんを含む多様な疾患領域で重要な役割を果たすことが明らかになってきている。特にEVに内包されるマイクロRNAやタンパク質は、腫瘍の進展や転移、免疫応答に関与することが報告されており、EVは次世代の診断バイオマーカーや治療標的として注目されている。
    当研究室では、独自に開発したEVシートを活用し、臓器表面の微量腹水中に存在するEVの解析を可能とした。EVシートは、わずか10μL程度の液体からでも非侵襲的かつ高効率にEVを回収できる画期的なプラットフォームである。本研究では、名古屋大学医学部附属病院産婦人科の手術症例に対して、EVシートを用いて横隔膜、膀胱、肝臓、腸間膜など複数の腹膜表面から微量腹水を採取した。各部位のEVを精製後、マイクロRNAシーケンスを行い、EVのプロファイルが臓器表面に応じて顕著に異なることを明らかにした。特に肝表面由来EVでは、他部位と比較して特定のマイクロRNAが高発現していることが判明した。さらに、肝表面は卵巣癌の播種転移が比較的少ないことから、この局所的EVの特性が腫瘍微小環境で抗腫瘍的に働く可能性が示唆された。この仮説に基づき、現在は肝表面由来EVが卵巣癌細胞に与える生物学的影響について、in vitroおよびin vivoモデルを用いて機能解析を進めている。また、EVシートの特性を活かし、微量腹水からのEVマイクロRNA解析による新規バイオマーカーの探索も並行して行っている。
    本研究は、腹水を「臓器表面ごとに性質の異なる空間的に多様な液体」と再定義するものであり、EV研究・がん研究の両面において学術的・臨床的に大きなインパクトをもたらすと考えられる。
    EVシートにより、ヒト生体における微量腹水の空間的な多様性を評価できている。そして、その解析結果に基づき卵巣癌抑制的なマイクロRNAを同定し、その機能解析を進めており、卵巣癌の新規治療薬に繋がる成果が得られることが期待されるため。また、微量腹水を用いたバイオマーカー研究についても、今後の成果が期待されるため。
    複数の肝表面EVマイクロRNAの抗腫瘍効果について、機能解析を進め、動物実験を通して新規核酸医薬としての可能性を検討する。EVマイクロRNAだけでなく、EVタンパク質にも着目した研究を実施し、腹腔内のEVの多様性について多角的な評価を行う。

  3. Identification and functional analysis of ovarian cancer-associated neutrophils and their investigation as novel therapeutic targets

    Grant number:24K12529  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  4. 腟内細菌由来エクソソームに着目した卵巣がん発生初期進展機構の解明

    Grant number:24K12528  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    稲見 恵理, 梶山 広明, 横井 暁

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    卵巣がんは予後の悪い悪性腫瘍で、主要サブタイプである高異型度漿液性がんは特に早期発見が困難かつ発見時多くの症例で腹膜播種性転移を既に生じておりそのメカニズム解明と新たな治療法の開発が望まれている。
    近年、乳癌や肺癌などのヒト固形腫瘍がん細胞中に細菌由来DNAが検出され、細菌が腫瘍悪性化やその多様性に寄与する可能性が示されている。
    我々は過去の研究から腟細菌叢の腫瘍への影響について確信し、菌体が直接卵管上皮細胞に影響するわけではなく、腟細菌叢が放出する細胞外小胞(bacterial EV: bEV)が影響していると仮説を立てた。bEVがどのように卵巣がん初期発生機構に関与するかを詳細に解析する。
    本研究は腟内細菌が放出する細胞外小胞(Bacterial Extracellular vesicles: BEV)がどのように高異型度漿液生卵巣がん(HGSC)発生の悪性化に関与するのかを解明することを目的としている。ヒト細胞由来EVに関する研究は過去10数年程で世界的に劇的に進んでいる。しかし、細菌が放出するEVは近年注目されはじめたばかりであり、まだその機能は未知である。数年前までは腫瘍多様性の原因として細菌の関与は上げられていないが、近年関連が示唆されはじめ、その役割の理解が求められている(Hanahan D. Cancer Discov 2022)。本研究はBEVという観点から卵巣がんの発生初期悪性化に関する研究を行うという点で、過去に報告のない新しい疾患メカニズムに言及でき、新しい知見を創出する。当該年度に予定していた①腟内BEVの分子プロファイリング②BEVを介する卵管上皮細胞(Fallopian tube cell:FT細胞)悪性化制御分子の探索と検証について計画をしていた。①では(a)7菌種から回収したBEV搭載RNAプロファイリング (b)卵巣がん患者卵管由来BEVの回収とRNAプロファイリング (c)卵巣がん患者組織を用いたBEV由来核酸の検証を行う。
    (a)(b)の結果より卵巣がん患者で発現の高い卵巣がん患者卵管由来BEV中のRNAの同定に成功した。(C)の卵巣がん患者組織を用いたBEV由来核酸の検証もサンプリングを行いRNA-seqを行いプロファイルを作成した。
    ②ではFT細胞遊走能を7種の菌体由来BEVで検証した結果、2種の菌体由来BEVに顕著な変化がみられたので、FTE細胞における非足場依存的増殖について検討した結果、BEVは非足場的依存増殖を亢進させる結果が見られた。またそれらのBEVを卵管細胞へ投与し、RNAを回収しRNA-seqでそのシグナル変化を観察した。現在同定した卵巣がん患者卵管采のBEV中で発現の高い核酸を合成、導入をして、BEV投与時と同様なシグナルが観察できるかについて検討中である。
    我々は既にBEVを回収し、そのsmall RNA-seqのプロファイリング解析とEVシートを用いて患者FTより採取したEV中バクテリアRNAを同定した。さらに卵巣がんで特異的に発現が上昇している核酸配列を同定している。そしてその配列を特許として申請中である。その特定した核酸配列が卵巣がんの初期悪性化に関わるかを検証するための実験系を既に立ち上げ核酸配列の合成にもとりかかっている。投与方法については今後検討が必要である。また卵巣がんはTP53の変異は共通しており、TP53が卵巣がん悪性化に関与する、そのためTP53をKOをしたりして、機能解析を予定しているが、CRISPAR-Cas9によるTP53KO FT細胞を作成中である。以上から概ね本研究は順調に進んでいると言える。
    我々は卵巣がん患者で発現が高いBEV由来核酸配列を同定している。今後はその機能解析を行なっていく予定である。必要な細胞等も現在準備中であり、本研究の推進が期待できる。

  5. Development of Novel Ovarian Cancer Treatment Strategies by Translational Analysis of Extracellular Vesicles

    Grant number:24K02586  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s) 

  6. Creation of a novel cancer stromal-targeted therapeutic strategy for refractory ovarian cancer based on the intraperitoneal ecosystem.

    Grant number:23K27732  2024.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\18850000 ( Direct Cost: \14500000 、 Indirect Cost:\4350000 )

  7. 卵巣癌腹膜微小環境を突破する新規CAR-T細胞療法の確立

    Grant number:23K18326  2023.6 - 2026.3

    科学研究費助成事業  挑戦的研究(萌芽)

    山北 由彦, 梶山 広明, 吉原 雅人, 富田 弘之, 小屋 美博

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    「キメラ抗原受容体遺伝子改変T細胞療法」(CAR-T療法)が実用化され、造血器腫瘍における劇的な治療効果から大きな注目を集めている。しかしながら固形腫瘍におけるCAR-T療法の治療効果は限定的であり、治療法の更なる改善が求められている。特に卵巣がん患者の腹腔内環境は、高度に免疫抑制状態にあることが報告されており、その要因の一つにがん性腹膜炎に伴う腹水の存在が挙げられる。本研究ではヒト臨床検体サンプルとゲノム編集技術を用いた機能遺伝子のゲノムワイドスクリーニング法を用いて、免疫抑制環境を解除する遺伝子を同定し、卵巣がんの腹腔内微小環境において有効な新規CAR-T遺伝子改変手法を開発する。
    キメラ抗原受容体(Chimeric Antigen Receptor; CAR)を応用した「キメラ抗原受容体遺伝子改変T細胞療法」(CAR-T療法)が実用化され、造血器腫瘍における劇的な治療効果から大きな注目を集めている。しかしながら固形腫瘍におけるCAR-T療法の治療効果は限定的であり、治療法の更なる改善が求められている。特に卵巣がん患者の腹腔内環境は、高度に免疫抑制状態にあることが報告されており、その要因の一つにがん性腹膜炎に伴う腹水の存在が挙げられる。つまりCAR遺伝子導入によりT細胞の抗腫瘍能強化を行ったとしても、がん性腹水が存在する難治性卵巣がん患者の腹腔内では、その傷害活性が高度に消失してしまうと考えられる。本研究では、難治性の進行・再発卵巣がんでの腹腔内免疫抑制環境を突破する新しいCAR-T細胞療法の創成を目的とする。
    本研究ではヒト臨床検体サンプルとゲノム編集技術を用いた機能遺伝子のゲノムワイドスクリーニング法とを用いて、免疫抑制環境を解除する遺伝子を同定し、卵巣がんの腹腔内微小環境において有効な新規CAR-T遺伝子改変手法を確立する。具体的にはヒト19,050遺伝子に対するsgRNAがデザインされたCRISPR/Cas9プールライブラリーシステム (human Genome-Scale CRISPR Knock-Out (GeCKO)) を利用して多種の遺伝子をノックアウトしたT細胞及びCAR-T細胞を調整し、それらに卵巣がん患者由来の腹水を投与することで、抑制状態を突破して機能する細胞を抽出、当該細胞群に濃縮されたsgRNA配列を指標に機能遺伝子を同定する。同定した機能遺伝子から候補遺伝子の絞り込み、それらをノックアウトしたCD19及び抗MSLN CAR-T細胞を作製して、卵巣がん腹膜播種モデルマウスにおいて薬効・動態の評価を行い、その有用性を検証する。
    本年度は、CAR-T細胞の増殖性に関連する新規遺伝子を同定するため、GeKOライブラリーを用いた遺伝子探索を実施し、複数の新規因子を同定した。具体的には、抗MSLN CAR-T細胞を大量に調製し、GeCKOライブラリーを組み込んだレンチウイルスベクターによって、guide RNAを挿入した。抗MSLN CAR-T細胞とMSLN陽性細胞株の大容量共培養を6回以上、3週間に渡って実施し、増殖性に優れたCAR-T細胞を濃縮した。当該CAR-T細胞からゲノムを抽出し、NGS解析を行うことで、関連遺伝子を同定することに成功した。
    抗MSLN CAR-T細胞の増殖能に関連すると推察される新規遺伝子を複数同定した。これらの遺伝子は、機能未知であり、CAR-T細胞における機能検証を行うことで、今後の新たな免疫療法の重要な標的になりえる。当該遺伝子の過剰発現や機能阻害をすることで、機能検証に加え、作用メカニズムの解析も実施する予定である。

  8. Development of intraperitoneal environmental strategies for advanced ovarian cancer focusing on peptid degradomics in ascites

    Grant number:21KK0157  2021.10 - 2025.3

    Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    Kajiyama Hiroaki

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    Authorship:Principal investigator 

    Grant amount:\18850000 ( Direct Cost: \14500000 、 Indirect Cost:\4350000 )

    This study focused on peritoneal dissemination, a particularly poor prognostic subtype of advanced ovarian cancer, and aimed to elucidate the mechanisms of tumor progression and the interactions among various components within the intraperitoneal tumor microenvironment, considered as an ecosystem including ascites, adipose tissue, and tumor-associated fibrosis. Utilizing omics analyses based primarily on mass spectrometry, the study investigated the diversity of the ascitic proteome and its association with disease progression, the dedifferentiation process of omental adipocytes and acquisition of tumor-promoting properties, as well as the identification of matrisome molecules involved in fibrosis induction. These findings demonstrated that ovarian cancer peritoneal dissemination progresses within a multifactorial tumor ecosystem and suggested that a multifaceted therapeutic approach targeting each of these components holds promise for effective treatment.

  9. Elucidating the mechanisms of intracellular communication within the peritoneal cavity inducing the construction of a dormancy-maintaining environment for occult cancer metastasis

    Grant number:21K19562  2021.7 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    Kajiyama Hiroaki

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    Authorship:Principal investigator 

    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

    Cancer patients with peritoneal dissemination often experience recurrence after a period of "dormancy," even if they achieve remission through treatment. Various cytotoxic antitumor drugs and molecular targets have been used as maintenance therapy, but unfortunately, none can completely eradicate the "dormant cancer cell clusters (seeds)." This study aims to elucidate, through interdisciplinary research, the mechanisms by which cancer-associated mesothelial cells (CAM) assist in the dormancy and evolution of tumor cells and help them evade attacks from existing antitumor drugs. By exploring the maintenance mechanisms of intra-abdominal occult seeding by CAM, we attempted to develop a comprehensive treatment strategy targeting the entire peritoneum and identify novel biomarkers.

  10. Development of Novel Ovarian Cancer Treatment Strategies by Translational Analysis of Extracellular Vesicles

    Grant number:21H03075  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Yokoi Akira

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    Authorship:Coinvestigator(s) 

    The purpose of this study was to clarify the biological significance of extracellular vesicles (EVs), including exosomes, in ovarian cancer, and to obtain fundamental knowledge for clinical application. In this study, research was conducted with three main themes: (1) functional analysis of EVs involved in ovarian cancer malignant transformation, (2) creation of EV biomarkers for personalized medicine, and (3) development of new treatment for refractory advanced ovarian cancer using EVs. During the research period, we were able to contribute to a total of 34 publications. Some of the seeds are expected to be developed for clinical application in the future, and we will continue to verify them.

  11. Analysis of the mechanism of anti-tumor immunosuppression by peritoneal mesothelial cells phagocytosed with ovarian cancer cells and investigation of the method for reactivation anti-tumor immunity

    Grant number:21K09492  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Koya Yoshihiro

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    Authorship:Coinvestigator(s) 

    Mesothelial cells (MCs) are the largest component of the peritoneal cavity and have been reported to have phagocytic capacity. In this study, we evaluated whether MCs exhibit phagocytosis against cancer cells and what kind of changes occur in phagocytosed MCs. The results showed that MCs have phagocytic activity against cell fragments of apoptotic cancer cells, and that the gene expression of molecules that induce immunosuppression was increased in MCs that phagocytosed these cancer cell fragments. It was suggested that phagocytosed MCs may contribute to the evasion of ovarian cancer cells from host antitumor immunity. We also found and evaluated cell surface molecules on the cancer cells. The results showed that these molecules are involved in invasive capacity, proliferative capacity, and spheroid formation.

  12. Interdisciplinary study on the peritoneal metastasis of patients with ovarian cancer based on the adipo-peritoneal crosstalk

    Grant number:20H03824  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Kajiyama Hiroaki

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    Authorship:Principal investigator 

    Grant amount:\17810000 ( Direct Cost: \13700000 、 Indirect Cost:\4110000 )

    In outcomes of this study, we investigated impact on the malignancy of ovarian cancer cells due to adipose-derived mesenchymal stem cells (ADSC) sourced from the omentum, through our unique ceiling culture method. We successfully demonstrated that proliferation of ovarian cancer cells, the enhanced motility of cancer cells, and the increased ability to form tumors in vivo, were all induced. We reported these series of results in a research paper. Moreover, we have previously identified that ovarian cancer-associated peritoneal mesothelial cells (OCAM) deeply contribute to progression of advanced ovarian cancer in the peritoneal microenvironment. We demonstrated that calcitriol (vitamin D) is a promising candidate substance to inhibit the process of normal peritoneal mesothelial cells transforming into OCAM, and reported these findings in a research paper as well.

  13. Development of "super-bio-functions" by plasma-activated biological substances

    Grant number:19H05462  2019.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Specially Promoted Research

    Hori Masaru

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    Authorship:Coinvestigator(s) 

    As components of plasma-activated Ringer's lactate solution (PAL), we have newly identified ethyl acetate, glyceric acid, and tricarballylic acid. We found that the combined administration of these three substances selectively kills cancer cells over normal cells. Furthermore, we discovered that selectively irradiating tryptophan with oxygen atoms generates tryptophan radicals with high efficiency. These radicals deactivate enzyme activities such as GAPDH within bacteria, leading to selective bacterial killing. Additionally, we elucidated that PAL induces a type of cell death called ferroptosis in mesothelioma cells and oral squamous epithelial cells. Furthermore, we have initiated a specific clinical study as a first-in-human trial using PAL.

  14. Elucidation of malignancy, peritoneal dissemination and spread mechanism of ovarian cancer by interaction with peritoneal mesothelium.

    Grant number:19H03797  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Kikkawa Fumitaka

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    Authorship:Coinvestigator(s) 

    The aim of this study was to elucidate new disease mechanisms by focusing on cell-cell interactions in the ovarian cancer tumor-microenvironment (TME), and to discover novel therapeutic targets for ovarian cancer patients. Throughout the three-year research period, we have elucidated the malignant mechanisms of refractory ovarian cancer from extremely multiple aspects. The research included metabolomic analysis, small RNA sequencing, therapeutic effects of vitamins, and the relationship with adipose tissue. All of the results are the whole new findings, which have been reported for the first time. The function of mesothelial cells in TME is still under investigation. Although this research grant is in its final year, we will continue to elucidate the functions of various cells in the ovarian cancer TME and leading to develop them for clinical applications such as diagnosis and treatment.

  15. Interdisciplinary research on intraperitoneal cell-to-cell crosstalk focusing ovarian cancer-associated mesothelial cells

    Grant number:17H04338  2017.4 - 2020.3

    Kajiyama Hiroaki

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    Authorship:Principal investigator 

    Grant amount:\17030000 ( Direct Cost: \13100000 、 Indirect Cost:\3930000 )

    We reported how ovarian cancer (OvCa)-associated mesothelial cells (OCAMs) induce platinum-resistance in OvCa cells through direct cell-to-cell crosstalk. We evaluated mutual associations between OvCa cells and human primary MCs with in vitro co-culturing experimental models and in silico omics data analysis. Results of in vitro experiments show that mesenchymal transition is induced in OCAMs primarily by TGF-β1 stimulation. OCAMs can induce decreased platinum-sensitivity in OvCa cells via induction of the FN1/Akt signaling pathway via cell-to-cell interactions. Further, we also confirmed activation of Akt signaling in OvCa cells in contact with TGF-β1 stimulated peritoneum, using an in vivo mice model. Their results suggest that the tumor microenvironment, enhanced by direct cell-to-cell crosstalk between OvCa cells and OCAMs, induces acquisition of platinum-resistance in OvCa cells, which may serve as a novel therapeutic target for prevention of OvCa peritoneal dissemination.

  16. Analysis of tumor-infiltrating lymphocytes in malignant gynecologic tumors for development of personalized tumor immunotherapy

    Grant number:16H05472  2016.4 - 2019.3

    Kikkawa Fumitaka

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    Authorship:Coinvestigator(s) 

    In order to develop personalized immunotherapy for malignant gynecologic tumors, we aimed to characterize tumor infiltrating lymphocytes (TIL) and to clarify the mutated neoantigens of individual patients with malignant gynecologic tumors.
    Although TIL yield varied between patient samples, we could expanded the TILs from the small fragments of tumor in most cases (97.6%). A total of 14 patient derived xenografts (PDX) models were established. It could be confirmed that the reactive cells to autologous tumor cells were present in the expanded TILs. In two cases with ovarian cancer, we identified candidates of mutated neoantigens by the next generation sequencing combined with bioinformatics prediction and evaluated TILs from the same patients.

  17. Elucidation of peritoneal dissemination mechanism by exosome from ovarian cancer and development of new treatment

    Grant number:16K15704  2016.4 - 2018.3

    Kikkawa Fumitaka

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    Authorship:Coinvestigator(s) 

    We demonstrated that the exosome from ovarian cancer stimulated the peritoneal dissemination. By mouse model the exosome also prompted abdominal metastasis and causes morphological change in mesothelial cells. This phenomenon was caused by induction of apoptosis. We observed that the exosome increased MMP1 expression in mesothelial cells.
    Using clinical data base, we observed that MMP1 is an important prognostic marker and there are ovarian cancer patients with ascites including MMP1 mRNA.
    In conclusion, the exosome including MMP1 mRNA may be a prognostic biomarker and a treatment target for preventing abdominal metastasis.

  18. Interdisciplinary study of obstetric management and gynecological rare tumor in Vietnam

    Grant number:15H02660  2015.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    FUMITAKA KIKKAWA

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    Authorship:Coinvestigator(s) 

    For the purpose of not only the development of obstetrics and gynecology in Vietnam, but also creation of evidence worldwide and building of medical research resources to Japan, we investigated obstetric management and gynecological rare tumor in Vietnam at several facilities in Vietnam. In the present study, several findings, which are related to improvement of mothers and children's prognosis,were gained. First, Pregnancy with dengue fever causes thrombocytopenia, which is at risk of postpartum hemorrhage. Second, cesarean section scar pregnancy with an increase in cesarean section rate in Vietnam, could be managed by medication for only selected patients. Third, evaluation of cardiac function by ultrasound examination for fetal growth restriction would be beneficial. Lastly, we found that there was a high secondary rate after molar pregnancy in Vietnam and preventive measures might improve it.

  19. Photodynamic diagnosis of ovarian cancer by 5-aminolevulinic acid and establishment of novel treatment

    Grant number:15K10713  2015.4 - 2018.3

    Mika Mizuno

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    Photodynamic therapy (PDT) is known as a minimally invasive treatment for cancer. 5-Aminolevulinic acid (ALA) is a precursor of the photosensitizing agent protoporphyrin IX (PpIX). We evaluated the efficacy of ALA-PDT and investigated relevant factors of enhancement of effect on various ovarian cancer cells in vitro and in vivo.
    We confirmed the effect of ALA-PDT using various ovarian cancer cell lines. Especially,we found that three cell lines of clear cell carcinoma, which is chemoresistance tumor,were also highly sensitive to ALA-PDT.The cell lines sensitive to ALA-PDT expressed PEPT1 (an ALA uptake transporter) adn the cell line resistant to ALA-PDT expressed ABCG2 (a PpIX export transporter). In the resistant cell line, a combination treatment with both ALA and an ABCG2 inhibitor resulted in the promotion of cytotoxic sensitivity in vitro.

  20. The development of tailor-made immunotherapy based on ovarian cancer local immunity analysis

    Grant number:15K10714  2015.4 - 2018.3

    Shibata Kiyoisumi

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    Authorship:Coinvestigator(s) 

    We aimed to determine the role of cancer-associated mesothelial cells (CAMCs) in the promotion of tumor neovascularization and vascular permeability via enhanced VEGF production and loclal immunologic effects. We examined whether a characteristic morphological change in human peritoneal mesothelial cells (HPMCs) was observed in the presence of malignant ascites and tumor-derived TGF-β. We focused on the enhanced production of VEGF in CAMCs and its crucial role in endothelial tube formation. We found that EOC-derived TGF-β induced typical EMT-like morphological alteration in HPMCs, which was associated with CAMCs. We further discovered that CAMCs play a crucial role in the enhanced VEGF production.Furethermore we showed that IL-33 secretion was elevated in high metastatic cell lines.The novel mechanism of CAMCs as a facilitator of EOC progression and immnunological effect are displayed by microenvironmental cell-to-cell communication.

  21. EMTを標的とする、微少環境ストレス誘導転移の解明と克服~卵巣癌の予後向上へ~

    2012.4

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  22. 難治性卵巣癌における上皮間葉転換に基づくオンコジェニック ストレス耐性のメカニズム

    2009 - 2012

    科学研究費補助金  若手研究A

    梶山広明

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    Authorship:Principal investigator 

  23. 上皮間葉転換に基づく細胞膜型ペプチド分解酵素を分子標的とした卵巣癌腹膜転移の抑制

    2006.4 - 2009.3

    科学研究費補助金  若手研究(A)

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    Authorship:Principal investigator 

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Industrial property rights 1

  1. 培養ディッシュ

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    Application no:実願2007-8102  Date applied:2007.10

    Patent/Registration no:507349020 

    Country of applicant:Domestic