Updated on 2021/04/05

写真a

 
KAJIYAMA, Hiroaki
 
Organization
Graduate School of Medicine Program in Integrated Medicine Medicine in Growth and Aging Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor
Contact information
メールアドレス

Degree 1

  1. 医博 ( 2002.6   名古屋大学 ) 

Research Interests 1

  1. Gynecologic Oncology

Research Areas 1

  1. Others / Others  / Obstetrics and Gynecology

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    1999.4 - 2002.6

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    1989.4 - 1995.3

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    Country: Japan

Professional Memberships 8

  1. 日本産科婦人科学会

  2. 日本癌治療学会

  3. 日本癌学会

  4. 日本婦人科腫瘍学会

  5. 日本東洋医学会

  6. 日本緩和医療学会

  7. 日本臨床腫瘍学会

  8. 日本臨床細胞学会

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Awards 1

  1. 日本産科婦人科学会学術奨励賞

    2007.4   日本産科婦人科学会  

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    Country:Japan

 

Papers 172

  1. *Is there any possibility of fertility-sparing surgery in patients with clear-cell carcinoma of the ovary? Reviewed

    Kajiyama H, Shibata K, Suzuki S, Ino K, Yamamoto E, Mizuno K, Sakakibara K, Matsuzawa K, Takeda A, Kinoshita Y, Kawai M, Nagasaka T, Nawa A, Kikkawa F.

      Vol. 111 ( 3 ) page: 523-6   2008.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  2. *Is there any association between retroperitoneal lymphadenectomy and survival benefit in ovarian clear cell carcinoma patients? Reviewed

    Suzuki S, Kajiyama H, Shibata K, Ino K, Nawa A, Sakakibara K, Matsuzawa K, Takeda A, Kinoshita Y, Kawai M, Nagasaka T, Kikkawa F.

    Ann Oncol.   Vol. 19 ( 7 ) page: 1284-7   2008.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  3. Stromal cell-derived factor-1alpha-induced cell proliferation and its possible regulation by CD26/dipeptidyl peptidase IV in endometrial adenocarcinoma. Reviewed

    Mizokami Y, Kajiyama H, Shibata K, Ino K, Kikkawa F, Mizutani S.

    Int J Cancer   Vol. 110 ( 5 ) page: 652-9   2004.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  4. Possible involvement of SDF-1alpha/CXCR4-DPPIV axis in TGF-beta1-induced enhancement of migratory potential in human peritoneal mesothelial cells. Reviewed

    Kajiyama H, Shibata K, Ino K, Nawa A, Mizutani S, Kikkawa F

    Cell Tissue Res.   Vol. 330 ( 2 ) page: 221-9   2007.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  5. Twist Expression Predicts Poor Clinical Outcome of Patients with Clear Cell Carcinoma of the Ovary. Reviewed

    Kajiyama H, Hosono S, Terauchi M, Shibata K, Ino K, Yamamoto E, Nomura S, Nawa A, Kikkawa F

    Oncology   Vol. 71 ( 5 ) page: 394-401   2007.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  6. Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells. Reviewed

    Kajiyama H, Shibata K, Terauchi M, Yamashita M, Ino K, Nawa A, Kikkawa F.

    Int J Oncol   Vol. 31 ( 2 ) page: 277-83   2007.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  7. Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo. Reviewed

    Yamashita M, Kajiyama H, Terauchi M, Shibata K, Ino K, Nawa A, Mizutani S, Kikkawa F

    Int J Cancer.   Vol. 120 ( 10 ) page: 2243-50   2007.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  8. Expression of Twist increases the risk for recurrence and for poor survival in epithelial ovarian carcinoma patients. Reviewed

    Hosono S, Kajiyama H, Terauchi M, Shibata K, Ino K, Nawa A, Kikkawa F

    Br J Cancer.   Vol. 96 ( 2 ) page: 314-20   2007.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  9. Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells Reviewed

    Kajiyama H, Shibata K, Terauchi M, Ino K, Nawa A, Kikkawa F.

    Ann N Y Acad Sci   Vol. 1086   page: 233-40   2006.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  10. Anti-progressive effect of neutral endopeptidase 24.11 (NEP/CD10) on cervical carcinoma in vitro and in vivo. Reviewed

    Terauchi M, Kajiyama H, Shibata K, Ino K, Mizutani S, Kikkawa F.

    Oncology   Vol. 69 ( 1 ) page: 52-62   2005.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  11. Neutral endopeptidase 24.11/CD10 suppresses progressive potential in ovarian carcinoma in vitro and in vivo. Reviewed

    Kajiyama H, Shibata K, Terauchi M, Morita T, Ino K, Mizutani S, Kikkawa F.

    Clin Cancer Res.   Vol. 11 ( 5 ) page: 1798-808   2005.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  12. *Involvement of SDF-1alpha/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma. Reviewed

    Kajiyama H, Shibata K, Terauchi M, Ino K, Nawa A, Kikkawa F.

    Int J Cancer   Vol. 122 ( 1 ) page: 91-9   2008.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  13. Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells. Reviewed

    Kajiyama H, Kikkawa F, Khin E, Shibata K, Ino K, Mizutani S.

    Cancer Res.   Vol. 63 ( 9 ) page: 2278-83   2003.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  14. *Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma. Reviewed

    Kajiyama H, Kikkawa F, Suzuki T, Shibata K, Ino K, Mizutani S.

    Cancer Res.   Vol. 62 ( 10 ) page: 2753-7   2002.5

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  15. Fertility-sparing surgery in patients with clear-cell carcinoma of the ovary: is it possible? Reviewed

    Kajiyama H, Shibata K, Mizuno M, Hosono S, Kawai M, Nagasaka T, Kikkawa F.

    Hum Reprod.   Vol. 26 ( 12 ) page: 3297-302   2101.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  16. Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity.

    Nakamura K, Niimi K, Yamamoto E, Ikeda Y, Nishino K, Suzuki S, Kajiyama H, Kikkawa F

    Biochemistry and biophysics reports   Vol. 26   page: 100951   2021.7

  17. Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia

    Ito Yumiko, Tsuda Hiroyuki, Imai Kenji, Miki Rika, Miura Mayo, Tachi Asuka, Tano Sho, Hirako-Takamura Shima, Moriyama Yoshinori, Ushida Takafumi, Kobayashi Tomoko, Sumigama Seiji, Kajiyama Hiroaki, Kikkawa Fumitaka, Kotani Tomomi

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 700   page: 108769   2021.3

  18. ChrXq27.3 miRNA cluster functions in cancer development.

    Yoshida K, Yokoi A, Yamamoto Y, Kajiyama H

    Journal of experimental & clinical cancer research : CR   Vol. 40 ( 1 ) page: 112   2021.3

  19. Antenatal prediction models for short- and medium-term outcomes in preterm infants

    Ushida Takafumi, Moriyama Yoshinori, Nakatochi Masahiro, Kobayashi Yumiko, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Hayakawa Masahiro, Kajiyama Hiroaki, Kotani Tomomi

    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA     2021.3

  20. Trisomy 5p with bilateral congenital diaphragmatic hernia: a case report.

    Nakamura N, Ushida T, Moriyama Y, Imai K, Nakano-Kobayashi T, Osuka S, Goto M, Kajiyama H, Asada H, Hayakawa M, Kotani T

    Journal of medical case reports   Vol. 15 ( 1 ) page: 114   2021.3

  21. Platelet counts during normal pregnancies and pregnancies complicated with hypertensive disorders.

    Ushida T, Kotani T, Moriyama Y, Imai K, Nakano-Kobayashi T, Kinoshita F, Nakamura N, Iitani Y, Yoshida S, Yamashita M, Kajiyama H

    Pregnancy hypertension   Vol. 24   page: 73 - 78   2021.3

  22. Does complete-staging lymphadenectomy improve survival outcomes in stage I endometrioid epithelial ovarian carcinoma? A multi-institutional retrospective study with propensity score-weighted analysis.

    Yoshihara M, Tamauchi S, Iyoshi S, Kitami K, Uno K, Tano S, Matsui S, Kajiyama H

    Japanese journal of clinical oncology   Vol. 51 ( 3 ) page: 387 - 392   2021.3

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  23. Shock Index and Postpartum Hemorrhage in Vaginal Deliveries: A Multicenter Retrospective Study.

    Ushida T, Kotani T, Imai K, Nakano-Kobayashi T, Nakamura N, Moriyama Y, Yoshida S, Yamashita M, Kajiyama H, Kikkawa F

    Shock (Augusta, Ga.)   Vol. 55 ( 3 ) page: 332 - 337   2021.3

  24. Postpartum alterations following inflammation in rat pregnancy: a discovery proteomic analysis.

    Ushida T, Kotani T, Moriyama Y, Hindmarch CCT, Cotechini T, Imai K, Nakano-Kobayashi T, Kajiyama H, Graham CH

    Reproduction (Cambridge, England)     2021.3

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  25. Preclinical Verification of the Efficacy and Safety of Aqueous Plasma for Ovarian Cancer Therapy

    Nakamura Kae, Yoshikawa Nobuhisa, Mizuno Yuko, Ito Miwa, Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka, Kajiyama Hiroaki

    CANCERS   Vol. 13 ( 5 )   2021.3

  26. Maternal low birth weight and hypertensive disorders of pregnancy

    Ushida Takafumi, Kotani Tomomi, Kinoshita Fumie, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki

    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH   Vol. 23   page: 5 - 10   2021.3

  27. Liver transaminase levels during pregnancy: a Japanese multicenter study

    Ushida Takafumi, Kotani Tomomi, Kinoshita Fumie, Imai Kenji, Nakano-Kobayashi Tomoko, Nakamura Noriyuki, Moriyama Yoshinori, Yoshida Shigeru, Yamashita Mamoru, Kajiyama Hiroaki

    JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE     page: 1 - 7   2021.2

  28. Expression of the chrXq27.3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance

    Yoshida Kosuke, Yokoi Akira, Sugiyama Mai, Oda Shingo, Kitami Kazuhisa, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka, Yokoi Tsuyoshi, Kajiyama Hiroaki

    ONCOGENE   Vol. 40 ( 7 ) page: 1255 - 1268   2021.2

  29. Extracellular miRNAs as Predictive Biomarkers for Glypican-3-Derived Peptide Vaccine Therapy Response in Ovarian Clear Cell Carcinoma

    Ukai Mayu, Yokoi Akira, Yoshida Kosuke, Suzuki Shiro, Shibata Kiyosumi, Kikkawa Fumitaka, Nakatsura Tetsuya, Kajiyama Hiroaki

    CANCERS   Vol. 13 ( 3 )   2021.2

  30. Active vitamin D inhibits mesothelial-mesenchymal-transition accelerating peritoneal dissemination in ovarian cancer

    Kitami Kazuhisa, Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Iyoshi Shohei, Uno Kaname, Mogi Kazumasa, Tamauchi Satoshi, Yokoi Akira, Yoshikawa Nobuhisa, Nawa Akihiro, Kajiyama Hiroaki

    CANCER SCIENCE   Vol. 112   page: 351 - 351   2021.2

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  31. Establishment of a patient-derived xenograft model and cell line of malignant transformation of mature cystic teratoma of the ovary

    Tamauchi Satoshi, Suzuki Shiro, Xuboya Chang, Yoshihara Masato, Yoshida Kosuke, Ikeda Yoshiki, Yoshikawa Nobuhisa, Kajiyama Hiroaki, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 2 ) page: 713 - 719   2021.2

  32. Anti-tumor effect of 9-oxo-10,12-ODA on human cervical cancer cells

    Koya Yoshihiro, Sugiyama Mai, Yoshihara Masato, Shibata Kiyosumi, Nawa Akihiro, Kajiyama Hiroaki

    CANCER SCIENCE   Vol. 112   page: 826 - 826   2021.2

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  33. How do peritoneal mesothelial cells on adipose tissue attract ovarian cancer cells?

    Mogi Kazumasa, Yoshihara Masato, Kitami Kazuhisa, Iyoshi Shohei, Uno Kaname, Tano Sho, Sugiyama Mai, Koya Yoshihiro, Tamauchi Satoshi, Yokoi Akira, Yoshikawa Nobuhisa, Nawa Akihiro, Kajiyama Hiroaki

    CANCER SCIENCE   Vol. 112   page: 341 - 341   2021.2

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  34. Visualization of platinum resistance through mapping trace elements

    Uno Kaname, Yoshikawa Nobuhisa, Yoshihara Masato, Tazaki Kei, Kato Masashi, Kitami Kazuhisa, Iyoshi Shohei, Tamauchi Satoshi, Sugiyama Mai, Koya Yoshihiro, Kajiyama Hiroaki

    CANCER SCIENCE   Vol. 112   page: 906 - 906   2021.2

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  35. The role of chrXq27.3 miRNA cluster in advanced ovarian clear cell carcinoma

    Yoshida Kosuke, Yokoi Akira, Yoshihara Masato, Tamauchi Satoshi, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Kikkawa Fumitaka, Kajiyama Hiroaki

    CANCER SCIENCE   Vol. 112   page: 291 - 291   2021.2

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  36. Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage

    Owaki Taro, Imai Kenji, Miki Rika, Niwa Yuri, Kotani Tomomi, Nakano-Kobayashi Tomoko, Ushida Takafumi, Kajiyama Hiroaki

    CYTOKINE   Vol. 138   page: 155406   2021.2

  37. Luteolin suppresses Ovarian Cancer progression via decrease the expression of VRK1

    Chang Xuboya, Kajiyama Hiroaki, Yoshikawa Nobuhisa, Yokoi Akira, Tamauchi Satoshi, Yoshihara Masato

    CANCER SCIENCE   Vol. 112   page: 770 - 770   2021.2

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  38. Intra-tumoral polarity induced by Notch signaling can be a novel therapeutic target for advanced ovarian cancer

    Yoshihara Masato, Sugiyama Mai, Koya Yoshihiro, Iyoshi Shohei, Kitami Kazuhisa, Uno Kaname, Mogi Kazumasa, Tano Sho, Tamauchi Satoshi, Yokoi Akira, Yoshikawa Nobuhisa, Nawa Akihiro, Kajiyama Hiroaki

    CANCER SCIENCE   Vol. 112   page: 363 - 363   2021.2

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  39. Mortality and neurological outcomes in extremely and very preterm infants born to mothers with hypertensive disorders of pregnancy

    Nakamura Noriyuki, Ushida Takafumi, Nakatochi Masahiro, Kobayashi Yumiko, Moriyama Yoshinori, Imai Kenji, Nakano-Kobayashi Tomoko, Hayakawa Masahiro, Kajiyama Hiroaki, Kikkawa Fumitaka, Kotani Tomomi

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 1729   2021.1

  40. Reduced response to controlled ovarian stimulation after radical trachelectomy: A pitfall of fertility-sparing surgery for cervical cancer

    Tamauchi Satoshi, Kajiyama Hiroaki, Osuka Satoko, Moriyama Yoshinori, Yoshihara Masato, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS     2021.1

  41. A uterine pseudotumor of immunoglobulinG4-related disease

    Senda Yasutaka, Ikeda Yoshiki, Tamauchi Satoshi, Yoshikawa Nobuhisa, Kikkawa Fumitaka, Kajiyama Hiroaki

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 47 ( 1 ) page: 430 - 435   2021.1

  42. The Prognostic Significance of Peritumoral Lymphocytes' Band-like Structure in Type II Endometrial Cancer

    Shimizu Yusuke, Suzuki Shiro, Ukai Mayu, Hattori Satomi, Yoshikawa Nobuhisa, Kajiyama Hiroaki

    ANTICANCER RESEARCH   Vol. 41 ( 1 ) page: 249 - 258   2021.1

  43. [Promotion of Equal Access to Medical Services for Children, Adolescent and Young Adult(CAYA)Cancer Patients with Reproductive Problems-A Nationwide Expansion of the Regional Oncofertility Network in Japan].

    Takenaka M, Furui T, Takae S, Sugishita Y, Kawahara T, Shigematsu K, Kimura F, Horie A, Hara T, Kato M, Nishiyama H, Suzuki T, Miyachi M, Kanenishi K, Kubo K, Nakayama S, Kajiyama H, Takai Y, Suzuki N

    Gan to kagaku ryoho. Cancer & chemotherapy   Vol. 47 ( 12 ) page: 1691 - 1696   2020.12

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  44. Efficacy of 5-aminolevulinic acid and LED photodynamic therapy in cervical intraepithelial neoplasia: A clinical trial

    Mizuno Mika, Mitsui Hiroko, Kajiyama Hiroaki, Teshigawara Toshiya, Inoue Katsushi, Takahashi Kiwamu, Ishii Takuya, Ishizuka Masahiro, Nakajima Motowo, Kikkawa Fumitaka

    PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY   Vol. 32   page: 102004   2020.12

  45. Microphthalmia-Associated Transcription Factor-Dependent Melanoma Cell Adhesion Molecule Activation Promotes Peritoneal Metastasis of Ovarian Cancer

    Kitami Kazuhisa, Yoshihara Masato, Koya Yoshihiro, Sugiyama Mai, Iyoshi Shohei, Uno Kaname, Mogi Kazumasa, Tano Sho, Fujimoto Hiroki, Nawa Akihiro, Kikkawa Fumitaka, Kajiyama Hiroaki

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 21 ( 24 )   2020.12

  46. Sarcopenia as a Predictor of Survival Among Patients With Organ Metastatic Cervical Cancer

    Yoshikawa Nobuhisa, Shirakawa Akira, Yoshida Kosuke, Tamauchi Satoshi, Suzuki Shiro, Kikkawa Fumitaka, Kajiyama Hiroaki

    NUTRITION IN CLINICAL PRACTICE   Vol. 35 ( 6 ) page: 1041 - 1046   2020.12

  47. Does uterine preservation affect survival outcomes of patients with stage I ovarian sex cord-stromal cell tumours? A multi-institutional study

    Yoshihara Masato, Tamauchi Satoshi, Iyoshi Shohei, Kitami Kazuhisa, Uno Kaname, Yoshikawa Nobuhisa, Ikeda Yoshiki, Kawai Michiyasu, Nagasaka Tetsuro, Kajiyama Hiroaki

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 254   page: 52 - 56   2020.11

  48. Adjusted multiple gases in the plasma flow induce differential antitumor potentials of plasma-activated solutions

    Nakamura Kae, Yoshikawa Nobuhisa, Yoshihara Masato, Ikeda Yoshiki, Higashida Akihiro, Niwa Akihiro, Jindo Takahiro, Tanaka Hiromasa, Ishikawa Kenji, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka, Kajiyama Hiroaki

    PLASMA PROCESSES AND POLYMERS   Vol. 17 ( 10 )   2020.10

  49. Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production

    Kawata Reo, Oda Shingo, Koya Yoshihiro, Kajiyama Hiroaki, Yokoi Tsuyoshi

    TOXICOLOGY   Vol. 443   page: 152544   2020.10

  50. Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice

    Hayashi Shotaro, Nakamura Tomoko, Motooka Yashiro, Ito Fumiya, Jiang Li, Akatsuka Shinya, Iwase Akira, Kajiyama Hiroaki, Kikkawa Fumitaka, Toyokuni Shinya

    REDOX BIOLOGY   Vol. 37   page: 101726   2020.10

  51. Long non-coding RNA: A recently accentuated molecule in chemoresistance in cancer

    Peng Yang, Tang Dihong, Zhao Meng, Kajiyama Hiroaki, Kikkawa Fumitaka, Kondo Yutaka

    CANCER AND METASTASIS REVIEWS   Vol. 39 ( 3 ) page: 825 - 835   2020.9

  52. Follicular dendritic cell sarcoma of the uterine cervix: a case report

    Nakamura Takuto, Yoshihara Masato, Tamauchi Satoshi, Kajiyama Hiroaki, Kikkawa Fumitaka

    BMC WOMENS HEALTH   Vol. 20 ( 1 ) page: 182   2020.8

  53. Survival after Anticancer Treatment of Terminally Ill Patients with Ovarian Carcinoma

    Kajiyama Hiroaki, Suzuki Shiro, Shimbo Akiko, Utsumi Fumi, Yoshikawa Nobuhisa, Kikkawa Fumitaka

    JOURNAL OF PALLIATIVE MEDICINE   Vol. 23 ( 8 ) page: 1060 - 1065   2020.8

  54. Impact of uterus-preserving surgery on Stage I primary mucinous epithelial ovarian carcinoma: A multi-institutional study with propensity score-weighted analysis

    Yoshihara Masato, Kajiyama Hiroaki, Tamauchi Satoshi, Iyoshi Shohei, Yokoi Akira, Suzuki Shiro, Kawai Michiyasu, Nagasaka Tetsuro, Takahashi Kunihiko, Matsui Shigeyuki, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS   Vol. 150 ( 2 ) page: 177 - 183   2020.8

  55. Non-thermal plasma-activated lactate solution kills U251SP glioblastoma cells in an innate reductive manner with altered metabolism

    Ishikawa Kenji, Hosoi Yugo, Tanaka Hiromasa, Jiang Li, Toyokuni Shinya, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Mizuno Masaaki, Hori Masaru

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 688   page: 108414   2020.7

  56. Filopodia play an important role in the trans-mesothelial migration of ovarian cancer cells

    Yoshihara Masato, Yamakita Yoshihiko, Kajiyama Hiroaki, Senga Takeshi, Koya Yoshihiro, Yamashita Mamoru, Nawa Akihiro, Kikkawa Fumitaka

    EXPERIMENTAL CELL RESEARCH   Vol. 392 ( 2 ) page: 112011   2020.7

  57. Exploration of small RNA biomarkers for testicular injury in the serum exosomes of rats

    Kawata Reo, Kagawa Takumi, Koya Yoshihiro, Kajiyama Hiroaki, Oda Shingo, Yokoi Tsuyoshi

    TOXICOLOGY   Vol. 440   page: 152490   2020.7

  58. The impact of systematic retroperitoneal lymphadenectomy on long-term oncologic outcome of women with advanced ovarian clear-cell carcinoma

    Kajiyama Hiroaki, Suzuki Shiro, Yoshikawa Nobuhisa, Tamauchi Satoshi, Shibata Kiyosumi, Kikkawa Fumitaka

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 31 ( 4 ) page: e47   2020.7

  59. The management of hydatidiform mole using prophylactic chemotherapy and hysterectomy for high-risk patients decreased the incidence of gestational trophoblastic neoplasia in Vietnam: a retrospective observational study

    Yamamoto Eiko, Tien Dat Minh, Sekiya Yoko, Tamakoshi Koji, Xuan Phuoc Nguyen, Nishino Kimihiro, Kotani Kaoru Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Quang Thanh Le, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 183 - 191   2020.5

  60. Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments

    Sassa Naoto, Yokoyama Yukihiro, Nishida Yoshihiro, Yamada Suguru, Uchida Hiroo, Kajiyama Hiroaki, Nagino Masato, Kodera Yasuhiro, Gotoh Momokazu

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 5 ) page: 929 - 936   2020.5

  61. Folate-appended cyclodextrin carrier targets ovarian cancer cells expressing the proton-coupled folate transporter

    Saito Shinichi, Koya Yoshihiro, Kajiyama Hiroaki, Yamashita Mamoru, Kikkawa Fumitaka, Nawa Akihiro

    CANCER SCIENCE   Vol. 111 ( 5 ) page: 1794 - 1804   2020.5

  62. Is cell block technique useful to predict histological type in patients with ovarian mass and/or body cavity fluids?

    Masekii Zenta, Kajiyama Hiroaki, Nishikawa Eri, Satake Tatsunari, Misawa Toshiya, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 225 - 235   2020.5

  63. Pegylated Liposomal Doxorubicin/Oxaliplatin Chemotherapy Can Overcome Cisplatin Resistance in Spectrin alpha II-Overexpressing Ovarian Carcinoma

    Maeda Osamu, Kajiyama Hiroaki, Shibata Kiyosumi, Nakamura Shigeo, Kikkawa Fumitaka

    ANTICANCER RESEARCH   Vol. 40 ( 5 ) page: 2497 - 2507   2020.5

  64. The Preoperative Prognostic Nutritional Index for the Prediction of Outcomes in Patients with Early-Stage Ovarian Clear Cell Carcinoma

    Yoshikawa Nobuhisa, Yoshida Kosuke, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 7135   2020.4

  65. The Therapeutic Effects of Goreisan, a Traditional Japanese Herbal Medicine, on Lower-Limb Lymphedema after Lymphadenectomy in Gynecologic Malignancies: A Case Series Study

    Yoshikawa Nobuhisa, Kajiyama Hiroaki, Otsuka Naoki, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Utsumi Fumi, Shibata Kiyosumi, Kikkawa Fumitaka

    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE   Vol. 2020   page: 6298293   2020.4

  66. Ovarian cancer-associated mesothelial cells induce acquired platinum-resistance in peritoneal metastasis via the FN1/Akt signaling pathway

    Yoshihara Masato, Kajiyama Hiroaki, Yokoi Akira, Sugiyama Mai, Koya Yoshihiro, Yamakita Yoshihiko, Liu Wenting, Nakamura Kae, Moriyama Yoshinori, Yasui Hiroaki, Suzuki Shiro, Yamamoto Yusuke, Ricciardelli Carmela, Nawa Akihiro, Shibata Kiyosumi, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CANCER   Vol. 146 ( 8 ) page: 2268 - 2280   2020.4

  67. How do doctors choose treatment for older gynecological cancer patients? A Japanese Gynecologic Oncology Group survey of gynecologic oncologists

    Yamamoto Makoto, Yoshida Yoshio, Itani Yoshio, Sato Shinya, Futagami Masayuki, Sakai Hitomi, Kajiyama Hiroaki, Ura Masaki Fujim, Aoki Yoichi

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 4 ) page: 741 - 745   2020.4

  68. Is standard radical surgery necessary for elderly patients with early-stage epithelial ovarian carcinoma? similar to Propensity score matched analysis similar to

    Kajiyama Hiroaki, Yoshihara Masato, Tamauchi Satoshi, Yoshikawa Nobuhisa, Niimi Kaoru, Suzuki Shiro, Shibata Kiyosumi, Kikkawa Fumitaka

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 50 ( 4 ) page: 411 - 418   2020.4

  69. Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology

    Naito Yoichi, Mishima Saori, Akagi Kiwamu, Igarashi Ataru, Ikeda Masafumi, Okano Susumu, Kato Shunsuke, Takano Tadao, Tsuchihara Katsuya, Terashima Keita, Nishihara Hiroshi, Nishiyama Hiroyki, Hiyama Eiso, Hirasawa Akira, Hosoi Hajime, Maeda Osamu, Yatabe Yasushi, Okamoto Wataru, Ono Shigeru, Kajiyama Hiroaki, Nagashima Fumio, Hatanaka Yutaka, Miyachi Mitsuru, Kodera Yasuhiro, Yoshino Takayuki, Taniguchi Hiroya

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 3 ) page: 403 - 417   2020.3

  70. CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway

    Yasui Hiroaki, Kajiyama Hiroaki, Tamauchi Satoshi, Suzuki Shiro, Peng Yang, Yoshikawa Nobuhisa, Sugiyama Mai, Nakamura Kae, Kikkawa Fumitaka

    CLINICAL & EXPERIMENTAL METASTASIS   Vol. 37 ( 1 ) page: 145 - 158   2020.2

  71. Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis

    Yoshihara Masato, Kajiyama Hiroaki, Tamauchi Satoshi, Iyoshi Shohei, Yokoi Akira, Suzuki Shiro, Kawai Michiyasu, Nagasaka Tetsuro, Takahashi Kunihiko, Matsui Shigeyuki, Kikkawa Fumitaka

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 50 ( 2 ) page: 145 - 151   2020.2

  72. The role of additional hysterectomy after concurrent chemoradiation for patients with locally advanced cervical cancer

    Yoshida Kosuke, Kajiyama Hiroaki, Yoshihara Masato, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 2 ) page: 384 - 390   2020.2

  73. Plasma-activated medium promotes autophagic cell death along with alteration of the mTOR pathway

    Yoshikawa Nobuhisa, Liu Wenting, Nakamura Kae, Yoshida Kosuke, Ikeda Yoshiki, Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 1614   2020.1

  74. Impact of age on clinicopathological features and survival of epithelial ovarian neoplasms in reproductive age

    Hanatani Maya, Yoshikawa Nobuhisa, Yoshida Kosuke, Tamauchi Satoshi, Ikeda Yoshiki, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kawai Michiyasu, Kajiyama Hiroaki, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 187 - 194   2020.1

  75. The efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide and actinomycin D in patients with choriocarcinoma and high-risk gestational trophoblastic neoplasia

    Sato Shizuka, Yamamoto Eiko, Niimi Kaoru, Ino Kazuhiko, Nishino Kimihiro, Suzuki Shiro, Kotani Tomomi, Kajiyama Hiroaki, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 25 ( 1 ) page: 203 - 209   2020.1

  76. Clinical Significance of Ubiquitin-associated Protein 2-like in Patients With Uterine Cervical Cancer

    Yoshida Kosuke, Kajiyama Hiroaki, Inami Eri, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka

    IN VIVO   Vol. 34 ( 1 ) page: 109 - 116   2020

  77. Complete Response of Recurrent Small Cell Carcinoma of the Uterine Cervix to Paclitaxel, Carboplatin, and Bevacizumab Combination Therapy

    Nakao Yuri, Tamauchi Satoshi, Yoshikawa Nobuhisa, Suzuki Shiro, Kajiyama Hiroaki, Kikkawa Fumitaka

    CASE REPORTS IN ONCOLOGY   Vol. 13 ( 1 ) page: 373 - 378   2020

  78. Fertility-sparing surgery and oncologic outcome among patients with early-stage ovarian cancer similar to propensity score- matched analysis similar to

    Kajiyama Hiroaki, Suzuki Shiro, Yoshikawa Nobuhisa, Kawai Michiyasu, Mizuno Kimio, Yamamuro Osamu, Nagasaka Tetsuro, Shibata Kiyosumi, Kikkawa Fumitaka

    BMC CANCER   Vol. 19 ( 1 ) page: 1235   2019.12

  79. Unique miRNA profiling of squamous cell carcinoma arising from ovarian mature teratoma: comprehensive miRNA sequence analysis of its molecular background

    Yoshida Kosuke, Yokoi Akira, Kagawa Takumi, Oda Shingo, Hattori Satomi, Tamauchi Satoshi, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Shibata Kiyosumi, Kajiyama Hiroaki, Yokoi Tsuyoshi, Kikkawa Fumitaka

    CARCINOGENESIS   Vol. 40 ( 12 ) page: 1435 - 1444   2019.12

  80. Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma

    Shimbo Akiko, Kajiyama Hiroaki, Tamauchi Satoshi, Yoshikawa Nobuhisa, Ikeda Yoshiki, Nishino Kimihiro, Suzuki Shiro, Niimi Kaoru, Sakata Jun, Kikkawa Fumitaka

    ONCOLOGY REPORTS   Vol. 42 ( 6 ) page: 2323 - 2332   2019.12

  81. The usefulness of bevacizumab for relief from symptomatic malignant ascites in patients with heavily treated recurrent ovarian cancer

    Shimizu Yusuke, Kajiyama Hiroaki, Yoshida Kosuke, Tamauchi Satoshi, Nakanishi Toru, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 45 ( 12 ) page: 2435 - 2439   2019.12

  82. COMPREHENSIVE MIRNA SEQUENCING OF SQUAMOUS CELL CARCINOMA ARISING FROM OVARIAN MATURE TERATOMA

    Yoshida K., Yokoi A., Tamauchi S., Ikeda Y., Yoshikawa N., Nishino K., Niimi K., Suzuki S., Kajiyama H., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29   page: A544 - A545   2019.11

  83. Prognostic factors and effects of fertility-sparing surgery in women of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis

    Yoshihara Masato, Kajiyama Hiroaki, Tamauchi Satoshi, Suzuki Shiro, Takahashi Kunihiko, Matsui Shigeyuki, Kikkawa Fumitaka

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 30 ( 6 ) page: e102   2019.11

  84. REDUCED RESPONSE TO CONTROLLED OVARIAN STIMULATION AFTER RADICAL TRACHELECTOMY

    Tamauchi S., Kajiyama H., Osuka S., Moriyama Y., Yoshihara M., Iyoshi S., Yoshida K., Ikeda Y., Yoshikawa N., Nishino K., Niimi K., Suzuki S., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29   page: A269 - A270   2019.11

  85. Prognostic value of neutrophil-to-lymphocyte ratio in early-stage ovarian clear-cell carcinoma

    Yoshida Kosuke, Yoshikawa Nobuhisa, Shirakawa Akira, Niimi Kaoru, Suzuki Shiro, Kajiyama Hiroaki, Kikkawa Fumitaka

    JOURNAL OF GYNECOLOGIC ONCOLOGY   Vol. 30 ( 6 ) page: e85   2019.11

  86. Fertility-Sparing surgery for young women with ovarian endometrioid carcinoma: a multicenteric comparative study using inverse probability of treatment weighting.

    Kajiyama H, Yoshihara M, Tamauchi S, Yoshikawa N, Suzuki S, Kikkawa F

    European journal of obstetrics & gynecology and reproductive biology: X   Vol. 4   page: 100071   2019.10

  87. Relationship between preexisting mental disorders and prognosis of gynecologic cancers: A case-control study

    Tamauchi Satoshi, Kajiyama Hiroaki, Moriyama Yoshinori, Yoshihara Masato, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 45 ( 10 ) page: 2082 - 2087   2019.10

  88. Oxidative stress-dependent and -independent death of glioblastoma cells induced by non-thermal plasma-exposed solutions

    Tanaka Hiromasa, Mizuno Masaaki, Katsumata Yuko, Ishikawa Kenji, Kondo Hiroki, Hashizume Hiroshi, Okazaki Yasumasa, Toyokuni Shinya, Nakamura Kae, Yoshikawa Nobuhisa, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 13657   2019.9

  89. Long-term oncologic outcome and its prognostic indicators in reproductive-age women with ovarian clear-cell carcinoma

    Kajiyama Hiroaki, Suzuki Shiro, Yoshikawa Nobuhisa, Niimi Kaoru, Kawai Michiyasu, Shibata Kiyosumi, Kikkawa Fumitaka

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   Vol. 300 ( 3 ) page: 717 - 724   2019.9

  90. Interleukin-33 expression in ovarian cancer and its possible suppression of peritoneal carcinomatosis

    Sekiya Atsushi, Suzuki Shiro, Tanaka Ayako, Hattori Satomi, Shimizu Yusuke, Yoshikawa Nobuhisa, Koya Yoshihiro, Kajiyama Hiroaki, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF ONCOLOGY   Vol. 55 ( 3 ) page: 755 - 765   2019.9

  91. Comparison of long-term oncologic outcomes between metastatic ovarian carcinoma originating from gastrointestinal organs and advanced mucinous ovarian carcinoma

    Kajiyama Hiroaki, Suzuki Shiro, Utsumi Fumi, Yoshikawa Nobuhisa, Nishino Kimihiro, Ikeda Yoshiki, Niimi Kaoru, Yamamoto Eiko, Kawai Michiyasu, Shibata Kiyosumi, Nagasaka Tetsuro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 8 ) page: 950 - 956   2019.8

  92. Oncologic and reproductive outcomes of cystectomy as a fertility-sparing treatment for early-stage epithelial ovarian cancer

    Kajiyama Hiroaki, Suzuki Shiro, Niimi Kaoru, Tamauchi Satoshi, Kawai Michiyasu, Nagasaka Tetsuro, Shibata Kiyosumi, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 7 ) page: 857 - 862   2019.7

  93. Oncologic outcomes after secondary surgery in recurrent clear-cell carcinoma of the ovary

    Kajiyama Hiroaki, Suzuki Shiro, Yoshikawa Nobuhisa, Kawai Michiyasu, Shibata Kiyosumi, Nagasaka Tetsuro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 29 ( 5 ) page: 910 - 915   2019.6

  94. Epidemiological overview of metastatic ovarian carcinoma: long-term experience of TOTSG database

    Kajiyama Hiroaki, Suzuki Shiro, Utsumi Fumi, Nishino Kimihiro, Niimi Kaoru, Mizuno Mika, Yoshikawa Nobuhisa, Kawai Michiyasu, Oguchi Hidenori, Mizuno Kimio, Yamamuro Osamu, Shibata Kiyosumi, Nagasaka Tetsuro, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page: 193 - 198   2019.5

  95. Does postoperative prophylactic irradiation of para-aortic lymph nodes reduce the risk of recurrence in uterine cervical cancer with positive pelvic lymph nodes?

    Yoshida Kosuke, Kajiyama Hiroaki, Yoshihara Masato, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 24 ( 5 ) page: 567 - 574   2019.5

  96. Urinary levels of the leukocyte surface molecule CD11b associate with glomerular inflammation in lupus nephritis

    Kitagawa Akimitsu, Tsuboi Naotake, Yokoe Yuki, Katsuno Takayuki, Ikeuchi Hidekazu, Kajiyama Hiroshi, Endo Nobuhide, Sawa Yuriko, Suwa Junya, Sugiyama Yutaka, Hachiya Asaka, Mimura Toshihide, Hiromura Keiju, Maruyama Shoichi

    KIDNEY INTERNATIONAL   Vol. 95 ( 3 ) page: 680 - 692   2019.3

  97. Endometriosis and cancer

    Kajiyama Hiroaki, Suzuki Shiro, Yoshihara Masato, Tamauchi Satoshi, Yoshikawa Nobuhisa, Niimi Kaoru, Shibata Kiyosumi, Kikkawa Fumitaka

    FREE RADICAL BIOLOGY AND MEDICINE   Vol. 133   page: 186 - 192   2019.3

  98. Survival impact of capsule status in stage I ovarian mucinous carcinoma-A mulicentric retrospective study

    Kajiyama Hiroaki, Suzuki Shiro, Yoshikawa Nobuhisa, Kawai Michiyasu, Nagasaka Tetsuro, Kikkawa Fumitaka

    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY   Vol. 234   page: 131 - 136   2019.3

  99. Non-thermal plasma-activated medium modified metabolomic profiles in the glycolysis of U251SP glioblastoma

    Kurake Naoyuki, Ishikawa Kenji, Tanaka Hiromasa, Hashizume Hiroshi, Nakamura Kae, Kajiyama Hiroaki, Toyokuni Shinya, Kikkawa Fumitaka, Mizuno Masaaki, Hori Masaru

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 662   page: 83 - 92   2019.2

  100. PAI-1 secreted from metastatic ovarian cancer cells triggers the tumor-promoting role of the mesothelium in a feedback loop to accelerate peritoneal dissemination

    Peng Yang, Kajiyama Hiroaki, Yuan Hong, Nakamura Kae, Yoshihara Masato, Yokoi Akira, Fujikake Kayo, Yasui Hiroaki, Yoshikawa Nobuhisa, Suzuki Shiro, Senga Takeshi, Shibata Kiyosumi, Kikkawa Fumitaka

    CANCER LETTERS   Vol. 442   page: 181 - 192   2019.2

  101. Estrogen producing ovarian fibrosarcoma: A case report

    Miura Mayo, Suzuki Shiro, Shibata Kiyosumi, Kajiyama Hiroaki, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 1 ) page: 171 - 176   2019.2

  102. Molecular mechanisms of non-thermal plasmainduced effects in cancer cells

    Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Toyokuni Shinya, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru

    BIOLOGICAL CHEMISTRY   Vol. 400 ( 1 ) page: 87 - 91   2019.1

  103. The role of extracellular RNAs in ovarian cancer

    Yokoi Akira, Yoshioka Yusuke, Yamamoto Yusuke, Matsuzaki Juntaro, Kato Tomoyasu, Kato Ken, Kajiyama Hiroaki, Kikkawa Fumitaka, Ochiya Takahiro

    CANCER SCIENCE   Vol. 109   page: 351 - 351   2018.12

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  104. Cancer-associated mesothelial cells as a potential therapeutic target in epithelial ovarian cancer

    Yoshihara Masato, Kajiyama Hiroaki, Sugiyama Mai, Koya Yoshihiro, Ryu Buntei, Yokoi Akira, Yamamoto Yusuke, Kikkawa Fumitaka

    CANCER SCIENCE   Vol. 109   page: 247 - 247   2018.12

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  105. Mesothelial cells create invasion frontier in peritoneal metastasis of epithelial ovarian cancer

    Iyoshi Shohei, Kajiyama Hiroaki, Yoshihara Masato, Yamakita Yoshihiko, Sugiyama Mai, Koya Yoshihiro, Ryu Buntei, Kikkawa Fumitaka

    CANCER SCIENCE   Vol. 109   page: 282 - 282   2018.12

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  106. Notch signaling enhances the mutual association with epithelial ovarian cancer and mesothelial cells

    Sugiyama Mai, Yoshihara Masato, Koya Yoshihiro, Yokoi Akira, Ryu Buntei, Kikkawa Fumitaka, Kajiyama Hiroaki

    CANCER SCIENCE   Vol. 109   page: 864 - 864   2018.12

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  107. MITF contributes to cell migration/invasion in ovarian carcinoma cells

    Koya Yoshihiro, Ryu Buntei, Sugiyama Mai, Yoshihara Masato, Senga Takeshi, Nawa Akihiro, Kikkawa Fumitaka, Kajiyama Hiroaki

    CANCER SCIENCE   Vol. 109   page: 503 - 503   2018.12

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  108. Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study

    Tamauchi Satoshi, Kajiyama Hiroaki, Yoshihara Masato, Ikeda Yoshiki, Yoshikawa Nobuhisa, Nishino Kimihiro, Utsumi Fumi, Niimi Kaoru, Suzuki Shiro, Kikkawa Fumitaka

    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY   Vol. 219 ( 4 ) page: 385.e1 - 385.e7   2018.10

  109. CANCER-ASSOCIATED MESOTHELIAL CELLS IN PERITONEAL METASTASIS OF EPITHELIAL OVARIAN CANCER AS A NOVEL THERAPEUTIC TARGET: 3D CO-CULTURE MODELS AND MULTI-OMICS ANALYSIS

    Masato Y., Kajiyama H., Yoshihiko Y., Mai S., Koya Y., Ryu B., Akira Y., Shiro S., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 187 - 188   2018.9

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  110. EFFECT OF CONCURRENT CHEMO-RADIOTHERAPY ON CLINICAL OUTCOMES IN SMALL CELL CARCINOMA OF THE UTERINE CERVIX

    Ikeda Y., Kajiyama H., Yoshida K., Yoshikawa N., Nishino K., Utsumi F., Niimi K., Suzuki S., Kawai M., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 294 - 294   2018.9

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  111. PROPENSITY SCORE ADJUSTED ANALYSIS OF PROPHYLACTIC IRRADIATION TO PARA-AORTIC LYMPH NODE AFTER RADICAL HYSTERECTOMY FOR UTERINE CERVICAL CANCER.

    Yoshida K., Yoshihara M., Ikeda Y., Yoshikawa N., Nishino K., Utumi F., Niimi K., Suzuki S., Kajiyama H., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 28   page: 447 - 447   2018.9

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  112. Hematopoietic lineage cell-specific protein 1 (HS1), a hidden player in migration, invasion, and tumor formation, is over-expressed in ovarian carcinoma cells.

    Koya Y, Liu W, Yamakita Y, Senga T, Shibata K, Yamashita M, Nawa A, Kikkawa F, Kajiyama H

    Oncotarget   Vol. 9 ( 66 ) page: 32609 - 32623   2018.8

  113. KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear-cell carcinoma cells

    Kawai Yosuke, Shibata Kiyosumi, Sakata Jun, Suzuki Shiro, Utsumi Fumi, Niimi Kaoru, Sekiya Ryuichiro, Senga Takeshi, Kikkawa Fumitaka, Kajiyama Hiroaki

    ONCOLOGY REPORTS   Vol. 40 ( 1 ) page: 195 - 205   2018.7

  114. The upregulated expression of vascular endothelial growth factor in surgically treated patients with recurrent/radioresistant cervical cancer of the uterus

    Yoshida Kosuke, Suzuki Shiro, Sakata Jun, Utsumi Fumi, Niimi Kaoru, Yoshikawa Nobuhisa, Nishino Kimihiro, Shibata Kiyosumi, Kikkawa Fumitaka, Kajiyama Hiroaki

    ONCOLOGY LETTERS   Vol. 16 ( 1 ) page: 515 - 521   2018.7

  115. Fertility-sparing surgery of malignant transformation arising from mature cystic teratoma of the ovary.

    Yoshikawa N, Teshigawara T, Ikeda Y, Nishino K, Sakata J, Utsumi F, Niimi K, Sekiya R, Suzuki S, Kawai M, Shibata K, Kikkawa F, Kajiyama H

    Oncotarget   Vol. 9 ( 44 ) page: 27564 - 27573   2018.6

  116. Hematopoietic lineage cell-specific protein 1 immunoreactivity indicates an increased risk of poor overall survival in patients with ovarian carcinoma

    Liu Wenting, Kajiyama Hiroaki, Shibata Kiyosumi, Koya Yoshihiro, Senga Takeshi, Kikkawa Fumitaka

    ONCOLOGY LETTERS   Vol. 15 ( 6 ) page: 9406 - 9412   2018.6

  117. Dengue fever during pregnancy.

    Tien Dat T, Kotani T, Yamamoto E, Shibata K, Moriyama Y, Tsuda H, Yamashita M, Kajiyama H, Duc Thien Minh D, Quang Thanh L, Kikkawa F

    Nagoya journal of medical science   Vol. 80 ( 2 ) page: 241 - 247   2018.5

  118. Dengue fever during pregnancy

    Trinh Tien Dat, Kotani Tomomi, Yamamoto Eiko, Shibata Kiyosumi, Moriyama Yoshinori, Tsuda Hiroyuki, Yamashita Mamoru, Kajiyama Hiroaki, Dien Duc Thien Minh, Le Quang Thanh, Kikkawa Fumitaka

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 80 ( 2 ) page: 241 - 247   2018.5

  119. Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model.

    Ohara Y, Chew SH, Misawa N, Wang S, Somiya D, Nakamura K, Kajiyama H, Kikkawa F, Tsuyuki Y, Jiang L, Yamashita K, Sekido Y, Lipson KE, Toyokuni S

    Oncotarget   Vol. 9 ( 26 ) page: 18494 - 18509   2018.4

  120. Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis

    Kochi Yuta, Kamatani Yoichiro, Kondo Yuya, Suzuki Akari, Kawakami Eiryo, Hiwa Ryosuke, Momozawa Yukihide, Fujimoto Manabu, Jinnin Masatoshi, Tanaka Yoshiya, Kanda Takashi, Cooper Robert G., Chinoy Hector, Rothwell Simon, Lamb Janine A., Vencovsky Jiri, Mann Herman, Ohmura Koichiro, Myouzen Keiko, Ishigaki Kazuyoshi, Nakashima Ran, Hosono Yuji, Tsuboi Hiroto, Kawasumi Hidenaga, Iwasaki Yukiko, Kajiyama Hiroshi, Horita Tetsuya, Ogawa-Momohara Mariko, Takamura Akito, Tsunoda Shinichiro, Shimizu Jun, Fujio Keishi, Amano Hirofumi, Mimori Akio, Kawakami Atsushi, Umehara Hisanori, Takeuchi Tsutomu, Sano Hajime, Muro Yoshinao, Atsumi Tatsuya, Mimura Toshihide, Kawaguchi Yasushi, Mimori Tsuneyo, Takahashi Atsushi, Kubo Michiaki, Kohsaka Hitoshi, Sumida Takayuki, Yamamoto Kazuhiko

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 77 ( 4 ) page: 602 - 611   2018.4

  121. Novel potential photodynamic therapy strategy using 5-Aminolevulinic acid for ovarian clear-cell carcinoma

    Teshigawara Toshiya, Mizuno Mika, Ishii Takuya, Kitajima Yuya, Utsumi Fumi, Sakata Jun, Kajiyama Hiroaki, Shibata Kiyosumi, Ishizuka Masahiro, Kikkawa Fumitaka

    PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY   Vol. 21   page: 121 - 127   2018.3

  122. Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium

    Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Takeda Keigo, Hashizume Hiroshi, Nakamura Kae, Utsumi Fumi, Kajiyama Hiroaki, Okazaki Yasumasa, Toyokuni Shinya, Akiyama Shinichi, Maruyama Shoichi, Kikkawa Fumitaka, Hori Masaru

    IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES   Vol. 2 ( 2 ) page: 99 - 102   2018.3

  123. Secondary cytoreductive surgery potentially improves the oncological outcomes of patients with recurrent uterine sarcomas

    Nakamura Kenichi, Kajiyama Hiroaki, Utsumi Fumi, Suzuki Shiro, Niimi Kaoru, Sekiya Ryuichiro, Sakata Jun, Yamamoto Eiko, Shibata Kiyosumi, Kikkawa Fumitaka

    MOLECULAR AND CLINICAL ONCOLOGY   Vol. 8 ( 3 ) page: 499 - 503   2018.3

  124. A post-recurrence survival-predicting indicator for cervical cancer from the analysis of 165 patients who developed recurrence.

    Yoshida K, Kajiyama H, Utsumi F, Niimi K, Sakata J, Suzuki S, Shibata K, Kikkawa F

    Molecular and clinical oncology   Vol. 8 ( 2 ) page: 281 - 285   2018.2

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    DOI: 10.3892/mco.2017.1530

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  125. The possible existence of occult metastasis in patients with ovarian clear-cell carcinoma who underwent complete resection without any residual tumours.

    Kajiyama H, Suzuki S, Yoshihara M, Nishino K, Yoshikawa N, Utsumi F, Niimi K, Mizuno M, Kawai M, Oguchi H, Mizuno K, Yamamuro O, Nagasaka T, Shibata K, Kikkawa F

    Oncotarget   Vol. 9 ( 5 ) page: 6298 - 6307   2018.1

  126. A novel mechanism of neovascularization in peritoneal dissemination via cancer-associated mesothelial cells affected by TGF-beta derived from ovarian cancer

    Fujikake Kayo, Kajiyama Hiroaki, Yoshihara Masato, Nishino Kimihiro, Yoshikawa Nobuhisa, Utsumi Fumi, Suzuki Shiro, Niimi Kaoru, Sakata Jun, Mitsui Hiroko, Shibata Kiyosumi, Senga Takeshi, Kikawa Fumitaka

    ONCOLOGY REPORTS   Vol. 39 ( 1 ) page: 193-200   2018.1

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    DOI: 10.3892/or.2017.6104

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  127. Efficacy of medroxyprogesterone acetate treatment and retreatment for atypical endometrial hyperplasia and endometrial cancer

    Tamauchi Satoshi, Kajiyama Hiroaki, Utsumi Fumi, Suzuki Shiro, Niimi Kaoru, Sakata Jun, Mizuno Mika, Shibata Kiyosumi, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 44 ( 1 ) page: 151 - 156   2018.1

  128. Carcinoma-associated mesothelial cells promote dissemination and platinum resistance in epithelial ovarian cancer.

    Yoshihara Masato, Kajiyama Hiroaki, Sugiyama Mai, Yasui Hiroaki, Koya Yoshihiro, Yamakita Yoshihiko, Ryu Buntei, Yokoi Akira, Yamamoto Yusuke, Kikkawa Fumitaka

    CANCER SCIENCE   Vol. 109   page: 118 - 118   2018.1

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  129. HS1 contributes cell migration/invasion and tumor formation in ovarian carcinoma

    Koya Yoshihiro, Liu Wenting, Yamakita Yoshihiko, Kajiyama Hiroaki, Senga Takeshi, Shibata Kiyosumi, Nawa Akihiro, Kikkawa Fumitaka

    CANCER SCIENCE   Vol. 109   page: 308 - 308   2018.1

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  130. The impact of chemokine in the peritoneal metastatic niche composed of ovarian cancer and peritoneal mesothelial cells

    Yasui Hiroaki, Kajiyama Hiroaki, Yoshihara Masato, Sugiyama Mai, Kikkawa Fumitaka

    CANCER SCIENCE   Vol. 109   page: 1013 - 1013   2018.1

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  131. Notch signaling enhances the mutual association with epithelial ovarian cancer and mesothelial cells

    Sugiyama Mai, Kajiyama Hiroaki, Yoshihara Masato, Yasui Hiroaki, Ryu Buntei, Koya Yoshihiro, Ymakita Yoshihiko, Kikkawa Fumitaka

    CANCER SCIENCE   Vol. 109   page: 1043 - 1043   2018.1

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  132. Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

    Yokoi Akira, Yoshioka Yusuke, Yamamoto Yusuke, Ishikawa Mitsuya, Kato Tomoyasu, Kiyono Tohru, Kajiyama Hiroaki, Kikkawa Fumitaka, Ochiya Takahiro

    CANCER SCIENCE   Vol. 109   page: 29 - 29   2018.1

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  133. HS1 immunoreactivity indicates increased risk of poor overall survival in ovarian carcinoma

    Liu Wenting, Kajiyama Hiroaki, Shibata Kiyosumi, Koya Yoshihiro, Senga Takeshi, Kikkawa Fumitaka

    CANCER SCIENCE   Vol. 109   page: 307 - 307   2018.1

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  134. Association of serum asymmetric dimethylarginine, homocysteine, and L-arginine concentrations during early pregnancy with hypertensive disorders of pregnancy

    Maruta Ei, Wang Jingwen, Kotani Tomomi, Tsuda Hiroyuki, Nakano Tomoko, Imai Kenji, Sumigama Seiji, Niwa Yoshimitsu, Mitsui Takashi, Yoshida Shigeru, Yamashita Mamoru, Nawa Akihiro, Tamakoshi Koji, Kajiyama Hiroaki, Kikkawa Fumitaka

    CLINICA CHIMICA ACTA   Vol. 475   page: 70 - 77   2017.12

  135. Inhibition of ZEB1 leads to inversion of metastatic characteristics and restoration of paclitaxel sensitivity of chronic chemoresistant ovarian carcinoma cells

    Sakata Jun, Utsumi Fumi, Suzuki Shiro, Niimi Kaoru, Yamamoto Eiko, Shibata Kiyosumi, Senga Takeshi, Kikkawa Fumitaka, Kajiyama Hiroaki

    ONCOTARGET   Vol. 8 ( 59 ) page: 99482 - 99494   2017.11

  136. ALTERATION OF THE TUMOR MICROENVIRONMENT BY NOTCH SINGNALING ENHANCES THE MUTUAL ASSOCIATION WITH EPITHELIAL OVARIAN CANCER AND MESOTHELIAL CALLS

    Yoshihara M., Kajiyama H., Sugiyama M., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 1726-1726   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  137. ALTERATION OF THE TUMOR MICROENVIRONMENT BY NOTCH SINGNALING ENHANCES THE MUTUAL ASSOCIATION WITH EPITHELIAL OVARIAN CANCER AND MESOTHELIAL CALLS

    Yoshihara M., Kajiyama H., Sugiyama M., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 563 - 563   2017.11

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  138. EVALUATING THE LONG TERM PROGNOSTIC FACTOR AND THE ROLE OF CYTOREDUCTION IN THE OVERALL POPULATION OF PATIENTS WITH CLINICAL AND SURGICAL STAGE IV ENDOMETRIAL CARCINOMA

    Shimizu Y., Kajiyama H., Suzuki S., Yoshikawa N., Nakamura K., Yoshihara M., Tamauchi S., Yoshida K., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 1213 - 1213   2017.11

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  139. ESTABLISHMENT AND CHARACTERISATION OF PATIENT-DERIVED XENOGRAFT MODELS FOR MALIGNANT GYNECOLOGIC TUMORS

    Suzuki S., Tamauchi S., Shimizu Y., Yoshihara M., Nakamura K., Yoshikawa N., Kajiyama H., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 1382 - 1382   2017.11

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  140. ESTABLISHMENT AND CHARACTERISATION OF PATIENT-DERIVED XENOGRAFT MODELS FOR MALIGNANT GYNECOLOGIC TUMORS

    Suzuki S., Tamauchi S., Shimizu Y., Yoshihara M., Nakamura K., Yoshikawa N., Kajiyama H., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 494 - 494   2017.11

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  141. PELVIC EXENTERATION IN PATIENTS WITH RECURRENT OR ADVANCED GYNECOLOGIC MALIGNANCIES

    Takuto N., Shimizu Y., Yoshihara M., Nakamura K., Yoshikawa N., Suzuki S., Kajiyama H., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 896 - 896   2017.11

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  142. PRIMA-1MET INDUCES APOPTOSIS THROUGH ACCUMULATION OF INTRACELLULAR REACTIVE OXYGEN SPECIES IRRESPECTIVE OF P53 STATUS AND CHEMO-SENSITIVITY IN EPITHELIAL OVARIAN CANCER CELLS

    Yoshikawa N., Shimizu Y., Yoshihara M., Nakamura K., Suzuki S., Kajiyama H., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 324 - 324   2017.11

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  143. PRIMA-1MET INDUCES APOPTOSIS THROUGH ACCUMULATION OF INTRACELLULAR REACTIVE OXYGEN SPECIES IRRESPECTIVE OF P53 STATUS AND CHEMO-SENSITIVITY IN EPITHELIAL OVARIAN CANCER CELLS

    Yoshikawa N., Shimizu Y., Yoshihara M., Nakamura K., Suzuki S., Kajiyama H., Kikkawa F.

    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER   Vol. 27   page: 84 - 84   2017.11

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  144. A combination of circulating miRNAs for the early detection of ovarian cancer

    Yokoi Akira, Yoshioka Yusuke, Hirakawa Akihiro, Yamamoto Yusuke, Ishikawa Mitsuya, Ikeda Shun-ichi, Kato Tomoyasu, Niimi Kaoru, Kajiyama Hiroaki, Kikkawa Fumitaka, Ochiya Takahiro

    ONCOTARGET   Vol. 8 ( 52 ) page: 89811 - 89823   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.20688

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    PubMed

  145. Crystallization of calcium oxalate dihydrate in a buffered calcium-containing glucose solution by irradiation with non-equilibrium atmospheric pressure plasma

    Kurake Naoyuki, Tanaka Hiromasa, Ishikawa Kenji, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Mizuno Masaaki, Ikehara Yuzuru, Hori Masaru

    JOURNAL OF APPLIED PHYSICS   Vol. 122 ( 14 )   2017.10

  146. Impact of positive ZEB1 expression in patients with epithelial ovarian carcinoma as an oncologic outcome-predicting indicator

    Sakata Jun, Kajiyama Hiroaki, Suzuki Shiro, Utsumi Fumi, Niimi Kaoru, Sekiya Ryuichiro, Shibata Kiyosumi, Senga Takeshi, Kikkawa Fumitaka

    ONCOLOGY LETTERS   Vol. 14 ( 4 ) page: 4287 - 4293   2017.10

  147. Establishment and characterization of cell lines derived from complete hydatidiform mole

    Yamamoto Eiko, Niimi Kaoru, Kiyono Tohru, Yamamoto Toshimichi, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka

    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE   Vol. 40 ( 3 ) page: 614 - 622   2017.9

  148. Novel Intraperitoneal Treatment With Non-Thermal Plasma-Activated Medium Inhibits Metastatic Potential of Ovarian Cancer Cells

    Nakamura Kae, Peng Yang, Utsumi Fumi, Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 6085   2017.7

  149. Intraperitoneal Administration of Plasma-Activated Medium: Proposal of a Novel Treatment Option for Peritoneal Metastasis From Gastric Cancer

    Takeda Shigeomi, Yamada Suguru, Hattori Norifumi, Nakamura Kae, Tanaka Hiromasa, Kajiyama Hiroaki, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Fujii Tsutomu, Fujiwara Michitaka, Mizuno Masaaki, Hori Masaru, Kodera Yasuhiro

    ANNALS OF SURGICAL ONCOLOGY   Vol. 24 ( 5 ) page: 1188 - 1194   2017.5

  150. Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer

    Miyauchi Rise, Itoh Yoshiyuki, Kawamura Mariko, Hirakawa Akihiro, Shibata Kiyosumi, Kajiyama Hiroaki, Nakahara Rie, Kubota Seiji, Ito Junji, Okada Tohru, Kikkawa Fumitaka, Naganawa Shinji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 79 ( 2 ) page: 211 - 220   2017.5

  151. Effects of center dot OH and center dot NO radicals in the aqueous phase on H2O2 and NO2- generated in plasma-activated medium

    Kurake Naoyuki, Tanaka Hiromasa, Ishikawa Kenji, Takeda Keigo, Hashizume Hiroshi, Nakamura Kae, Kajiyama Hiroaki, Kondo Takashi, Kikkawa Fumitaka, Mizuno Masaaki, Hori Masaru

    JOURNAL OF PHYSICS D-APPLIED PHYSICS   Vol. 50 ( 15 )   2017.3

  152. Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

    Yokoi Akira, Yoshioka Yusuke, Yamamoto Yusuke, Ishikawa Mitsuya, Ikeda Shun-ichi, Kato Tomoyasu, Kiyono Tohru, Takeshita Fumitaka, Kajiyama Hiroaki, Kikkawa Fumitaka, Ochiya Takahiro

    NATURE COMMUNICATIONS   Vol. 8   page: 14470   2017.3

  153. Clinical significance and predicting indicators of post-cancer-treatment survival in terminally ill patients with ovarian cancer

    Utsumi Fumi, Kajiyama Hiroaki, Niimi Kaoru, Sekiya Ryuichiro, Sakata Jun, Suzuki Shiro, Shibata Kiyosumi, Mizuno Mika, Kikkawa Fumitaka

    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH   Vol. 43 ( 2 ) page: 365 - 370   2017.2

  154. Future perspective of strategic non-thermal plasma therapy for cancer treatment

    Kajiyama Hiroaki, Utsumi Fumi, Nakamura Kae, Tanaka Hiromasa, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka

    JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION   Vol. 60 ( 1 ) page: 33 - 38   2017.1

  155. c-Rel Promotes Invasion of Choriocarcinoma Cells via PI3K/AKT Signaling

    Sekiya Yoko, Yamamoto Eiko, Niimi Kaoru, Nishino Kimihiro, Nakamura Kenichi, Kotani Tomomi, Kajiyama Hiroaki, Shibata Kiyosumi, Kikkawa Fumitaka

    ONCOLOGY   Vol. 92 ( 5 ) page: 299 - 310   2017

  156. A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age. Reviewed

    Kajiyama H, Mizuno M, Shibata K, Umezu T, Suzuki S, Yamamoto E, Mitsui H, Sekiya R, Niimi K, Kawai M, Nagasaka T, Kikkawa F.

    Int J Clin Oncol.   Vol. 19 ( 5 ) page: 921-7   2014.10

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  157. Oncologic outcome after recurrence in patients with stage I epithelial ovarian cancer: are clear-cell and mucinous histological types a different entities? Reviewed

    Kajiyama H, Mizuno M, Shibata K, Umezu T, Suzuki S, Yamamoto E, Mitsui H, Sekiya R, Niimi K, Kawai M, Nagasaka T, Kikkawa F.

    Eur J Obstet Gynecol Reprod Biol.   Vol. 181   page: 305-10   2014.10

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  158. PLAGL2 regulates actin cytoskeletal architecture and cell migration. Reviewed

    Sekiya R, Maeda M, Yuan H, Asano E, Hyodo T, Hasegawa H, Ito S, Shibata K, Hamaguchi M, Kikkawa F, Kajiyama H, Senga T.

    Carcinogenesis.     2014.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/carcin/bgu081.

  159. Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells. Reviewed

    Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells.

    Mol Cancer Ther.   Vol. 13 ( 8 ) page: 2081-91   2014.8

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  160. Selective cytotoxicity of indirect nonequilibrium atmospheric pressure plasma against ovarian clear-cell carcinoma. Reviewed

    Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Hori M, Kikkawa F.

    Springerplus.     page: 10.1186/2193-1801-3-398   2014.7

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  161. Survival benefit of taxane plus platinum in recurrent ovarian cancer with non-clear cell, non-mucinous histology. Reviewed

    Kajiyama H, Shibata K, Mizuno M, Umezu T, Suzuki S, Sekiya R, Niimi K, Mitsui H, Yamamoto E, Kawai M, Nagasaka T, Kikkawa F.

    J Gynecol Oncol.   Vol. 25 ( 1 ) page: 43-50   2014.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  162. Recurrence-predicting prognostic factors for patients with early-stage epithelial ovarian cancer undergoing fertility-sparing surgery: a multi-institutional study. Reviewed

    Kajiyama H, Mizuno M, Shibata K, Yamamoto E, Kawai M, Nagasaka T, Kikkawa F.

    Eur J Obstet Gynecol Reprod Biol.     page: 10.1016/j.ejogrb.2014.01.014.   2014.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  163. Is there any association between where patients spend the end of life and survival after anticancer treatment for gynecologic malignancy? Reviewed

    Kajiyama H, Utsumi F, Higashi M, Sakata J, Sekiya R, Mizuno M, Umezu T, Suzuki S, Yamamoto E, Mitsui H, Niimi K, Shibata K, Kikkawa F.

    J Palliat Med.   Vol. 17 ( 3 ) page: 325-30   2014.3

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  164. Effect of indirect nonequilibrium atmospheric pressure plasma on anti-proliferative activity against chronic chemo-resistant ovarian cancer cells in vitro and in vivo. Reviewed

    Utsumi F, Kajiyama H, Nakamura K, Tanaka H, Mizuno M, Ishikawa K, Kondo H, Kano H, Hori M, Kikkawa F.

    PLoS One.     page: 10.1371/journal.pone.0081576.   2013.12

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  165. Long-term clinical outcome of patients with recurrent epithelial ovarian carcinoma: is it the same for each histological type? Reviewed

      Vol. 22 ( 3 ) page: 394-9   2012.3

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  166. Postrecurrent oncologic outcome of patients with ovarian clear cell carcinoma. Reviewed

    Kajiyama H, Shibata K, Mizuno M, Yamamoto E, Fujiwara S, Umezu T, Suzuki S, Nakanishi T, Nagasaka T, Kikkawa F.

    Int J Gynecol Cancer.     page: 10.1097/IGC.0b013e3182540145.   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/IGC.0b013e3182540145.

  167. Expression of Twist enhances risk of poor oncologic outcome in patients with stage Ib to II cervical carcinoma with lymphovascular space involvement. Reviewed

        page: doi:pii: S0046-8177(12)00190-6   2012

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    DOI: doi:pii: S0046-8177(12)00190-6

  168. Long-term survival of young women receiving fertility-sparing surgery for ovarian cancer in comparison with those undergoing radical surgery. Reviewed

    Kajiyama H, Shibata K, Mizuno M, Umezu T, Suzuki S, Nawa A, Kawai M, Nagasaka T, Kikkawa F.

    Br J Cancer   Vol. 105 ( 9 ) page: 1288-94   2011.11

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  169. *Fertility-sparing surgery in young women with invasive epithelial ovarian cancer. Reviewed

    Kajiyama H, Shibata K, Suzuki S, Ino K, Nawa A, Kawai M, Nagasaka T, Kikkawa F.

    Eur J Surg Oncol. 2010   Vol. in press   2010

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  170. Fertility-sparing surgery in young women with invasive epithelial ovarian cancer. Reviewed

    Kajiyama H, Shibata K, Suzuki S, Ino K, Nawa A, Kawai M, Nagasaka T, KikkawaF.

    Eur J Surg Oncol.   Vol. 36 ( 4 ) page: 404-8   2010

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  171. The expression ofdipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells. Reviewed

    Kajiyama H, Shibata K, Ino K, Mizutani S, Nawa A, Kikkawa F

    Cancer Sci.   Vol. 101 ( 2 ) page: 347-54   2010

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  172. The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells. Reviewed

    Kajiyama H, Shibata K, Ino K, Mizutani S, Nawa A, Kikkawa F.

    Cancer Sci. 2009   Vol. in press   2009

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. 上皮間葉転換に基づく細胞膜型ペプチド分解酵素を分子標的とした卵巣癌腹膜転移の抑制

    2006

KAKENHI (Grants-in-Aid for Scientific Research) 12

  1. Interdisciplinary study on the peritoneal metastasis of patients with ovarian cancer based on the adipo-peritoneal crosstalk

    Grant number:20H03824  2020.4 - 2023.3

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    Authorship:Principal investigator 

    Grant amount:\17810000 ( Direct Cost: \13700000 、 Indirect Cost:\4110000 )

  2. Development of "super-bio-functions" by plasma-activated biological substances

    Grant number:19H05462  2019.4 - 2024.3

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    Authorship:Coinvestigator(s) 

  3. Elucidation of malignancy, peritoneal dissemination and spread mechanism of ovarian cancer by interaction with peritoneal mesothelium.

    Grant number:19H03797  2019.4 - 2022.3

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    Authorship:Coinvestigator(s) 

  4. Interdisciplinary research on intraperitoneal cell-to-cell crosstalk focusing ovarian cancer-associated mesothelial cells

    Grant number:17H04338  2017.4 - 2020.3

    Kajiyama Hiroaki

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    Authorship:Principal investigator 

    Grant amount:\17030000 ( Direct Cost: \13100000 、 Indirect Cost:\3930000 )

    We reported how ovarian cancer (OvCa)-associated mesothelial cells (OCAMs) induce platinum-resistance in OvCa cells through direct cell-to-cell crosstalk. We evaluated mutual associations between OvCa cells and human primary MCs with in vitro co-culturing experimental models and in silico omics data analysis. Results of in vitro experiments show that mesenchymal transition is induced in OCAMs primarily by TGF-β1 stimulation. OCAMs can induce decreased platinum-sensitivity in OvCa cells via induction of the FN1/Akt signaling pathway via cell-to-cell interactions. Further, we also confirmed activation of Akt signaling in OvCa cells in contact with TGF-β1 stimulated peritoneum, using an in vivo mice model. Their results suggest that the tumor microenvironment, enhanced by direct cell-to-cell crosstalk between OvCa cells and OCAMs, induces acquisition of platinum-resistance in OvCa cells, which may serve as a novel therapeutic target for prevention of OvCa peritoneal dissemination.

  5. Analysis of tumor-infiltrating lymphocytes in malignant gynecologic tumors for development of personalized tumor immunotherapy

    Grant number:16H05472  2016.4 - 2019.3

    Kikkawa Fumitaka

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    Authorship:Coinvestigator(s) 

    In order to develop personalized immunotherapy for malignant gynecologic tumors, we aimed to characterize tumor infiltrating lymphocytes (TIL) and to clarify the mutated neoantigens of individual patients with malignant gynecologic tumors.
    Although TIL yield varied between patient samples, we could expanded the TILs from the small fragments of tumor in most cases (97.6%). A total of 14 patient derived xenografts (PDX) models were established. It could be confirmed that the reactive cells to autologous tumor cells were present in the expanded TILs. In two cases with ovarian cancer, we identified candidates of mutated neoantigens by the next generation sequencing combined with bioinformatics prediction and evaluated TILs from the same patients.

  6. Elucidation of peritoneal dissemination mechanism by exosome from ovarian cancer and development of new treatment

    Grant number:16K15704  2016.4 - 2018.3

    Kikkawa Fumitaka

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    We demonstrated that the exosome from ovarian cancer stimulated the peritoneal dissemination. By mouse model the exosome also prompted abdominal metastasis and causes morphological change in mesothelial cells. This phenomenon was caused by induction of apoptosis. We observed that the exosome increased MMP1 expression in mesothelial cells.
    Using clinical data base, we observed that MMP1 is an important prognostic marker and there are ovarian cancer patients with ascites including MMP1 mRNA.
    In conclusion, the exosome including MMP1 mRNA may be a prognostic biomarker and a treatment target for preventing abdominal metastasis.

  7. Interdisciplinary study of obstetric management and gynecological rare tumor in Vietnam

    Grant number:15H02660  2015.4 - 2020.3

    FUMITAKA KIKKAWA

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    For the purpose of not only the development of obstetrics and gynecology in Vietnam, but also creation of evidence worldwide and building of medical research resources to Japan, we investigated obstetric management and gynecological rare tumor in Vietnam at several facilities in Vietnam. In the present study, several findings, which are related to improvement of mothers and children's prognosis,were gained. First, Pregnancy with dengue fever causes thrombocytopenia, which is at risk of postpartum hemorrhage. Second, cesarean section scar pregnancy with an increase in cesarean section rate in Vietnam, could be managed by medication for only selected patients. Third, evaluation of cardiac function by ultrasound examination for fetal growth restriction would be beneficial. Lastly, we found that there was a high secondary rate after molar pregnancy in Vietnam and preventive measures might improve it.

  8. Photodynamic diagnosis of ovarian cancer by 5-aminolevulinic acid and establishment of novel treatment

    Grant number:15K10713  2015.4 - 2018.3

    Mika Mizuno

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    Photodynamic therapy (PDT) is known as a minimally invasive treatment for cancer. 5-Aminolevulinic acid (ALA) is a precursor of the photosensitizing agent protoporphyrin IX (PpIX). We evaluated the efficacy of ALA-PDT and investigated relevant factors of enhancement of effect on various ovarian cancer cells in vitro and in vivo.
    We confirmed the effect of ALA-PDT using various ovarian cancer cell lines. Especially,we found that three cell lines of clear cell carcinoma, which is chemoresistance tumor,were also highly sensitive to ALA-PDT.The cell lines sensitive to ALA-PDT expressed PEPT1 (an ALA uptake transporter) adn the cell line resistant to ALA-PDT expressed ABCG2 (a PpIX export transporter). In the resistant cell line, a combination treatment with both ALA and an ABCG2 inhibitor resulted in the promotion of cytotoxic sensitivity in vitro.

  9. The development of tailor-made immunotherapy based on ovarian cancer local immunity analysis

    Grant number:15K10714  2015.4 - 2018.3

    Shibata Kiyoisumi

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    Authorship:Coinvestigator(s) 

    We aimed to determine the role of cancer-associated mesothelial cells (CAMCs) in the promotion of tumor neovascularization and vascular permeability via enhanced VEGF production and loclal immunologic effects. We examined whether a characteristic morphological change in human peritoneal mesothelial cells (HPMCs) was observed in the presence of malignant ascites and tumor-derived TGF-β. We focused on the enhanced production of VEGF in CAMCs and its crucial role in endothelial tube formation. We found that EOC-derived TGF-β induced typical EMT-like morphological alteration in HPMCs, which was associated with CAMCs. We further discovered that CAMCs play a crucial role in the enhanced VEGF production.Furethermore we showed that IL-33 secretion was elevated in high metastatic cell lines.The novel mechanism of CAMCs as a facilitator of EOC progression and immnunological effect are displayed by microenvironmental cell-to-cell communication.

  10. EMTを標的とする、微少環境ストレス誘導転移の解明と克服~卵巣癌の予後向上へ~

    2012.4

    科学研究費補助金  基盤研究(B)

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    Authorship:Principal investigator 

  11. 難治性卵巣癌における上皮間葉転換に基づくオンコジェニック ストレス耐性のメカニズム

    2009 - 2012

    科学研究費補助金  若手研究A

    梶山広明

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    Authorship:Principal investigator 

  12. 上皮間葉転換に基づく細胞膜型ペプチド分解酵素を分子標的とした卵巣癌腹膜転移の抑制

    2006.4 - 2009.3

    科学研究費補助金  若手研究(A)

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    Authorship:Principal investigator 

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Industrial property rights 1

  1. 培養ディッシュ

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    Application no:実願2007-8102  Date applied:2007.10

    Patent/Registration no:507349020 

    Country of applicant:Domestic