Updated on 2021/03/31

写真a

 
AKASHI, Tomohiro
 
Organization
Graduate School of Medicine Center for Neural Disease and Cancer Assistant Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Assistant Professor

Degree 1

  1. 理学博士 ( 1990.3   大阪大学 ) 

Research Interests 1

  1. microtubule, tubulin, cell division, cell polarity, mitotic inhibitors, secondary metabolism

Research Areas 2

  1. Life Science / Cell biology  / Cell Biology

  2. Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules  / Living Organism Molecular Science

Current Research Project and SDGs 3

  1. multi-omics analysis of fungal secondary metabolites

  2. Molecular Biology of γ-tubulins in non-animal cells

  3. The role of secretion and cytoskeleton in apical growth of fungi

Research History 1

  1. Nagoya University

    2008.4

Education 1

  1. Osaka University   Graduate School, Division of Natural Science

    - 1990.3

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    Country: Japan

Professional Memberships 3

  1. Americal Society of Cell Biology

  2. 植物形態学会

  3. 植物学会

Awards 2

  1. 日本植物形態学会平瀬賞

    2004.9   日本植物形態学会  

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    Country:Japan

  2. 日本植物形態学会奨励賞

    2002.9   日本植物形態学会  

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    Country:Japan

 

Papers 29

  1. Hybrid Transcription Factor Engineering Activates the Silent Secondary Metabolite Gene Cluster for (+)-Asperlin in Aspergillus nidulans

    Grau Michelle F., Entwistle Ruth, Chiang Yi-Ming, Ahuja Manmeet, Oakley C. Elizabeth, Akashi Tomohiro, Wang Clay C. C., Todd Richard B., Oaldey Berl R.

    ACS CHEMICAL BIOLOGY   Vol. 13 ( 11 ) page: 3193-3205   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acschembio.8b00679

    Web of Science

    PubMed

  2. Discovery of McrA, a master regulator of Aspergillus secondary metabolism Reviewed

    C. E. Oakley, M. Ahuja, W.-W. Sun, R. Entwistle, T. Akashi, J. Yaegashi, C.-J. Guo, G. C. Cerqueira, J. R. Wortman, C. C. C. Wang, Y.-M. Chiang, B. R. Oakley

    Mol Microbial   Vol. 103 ( 2 ) page: 347–365   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/mmi.13562

  3. Near Infrared Photo-Antimicrobial Targeting Therapy for Candida albicans

    Yasui Hirotoshi, Takahashi Kazuomi, Taki Shunichi, Shimizu Misae, Koike Chiaki, Umeda Koji, Rahman Shofiqur, Akashi Tomohiro, Nguyen Van Sa, Nakagawa Yoshiyuki, Sato Kazuhide

    ADVANCED THERAPEUTICS     2021.1

  4. Quantitative Assessment of T Cell Clonotypes in Human Acute Graft-versus-Host Disease Tissues.

    Koyama D, Murata M, Hanajiri R, Akashi T, Okuno S, Kamoshita S, Julamanee J, Takagi E, Miyao K, Sakemura R, Goto T, Terakura S, Nishida T, Kiyoi H

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation   Vol. 25 ( 3 ) page: 417 - 423   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbmt.2018.10.012

    Web of Science

    PubMed

  5. A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma Reviewed

    Mu P, Akashi T, Lu F, Kishida S, Kadomatsu K.

    Oncogene   Vol. 36 ( 41 ) page: 5745-5756   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/onc.2017.181

  6. A Child with Epidermolytic Ichthyosis from a Parent with Epidermolytic Nevus: Risk Evaluation of Transmission from Mosaic to Germline. Reviewed

    Kono M, Suga Y, Akashi T, Ito Y, Takeichi T, Muro Y, Akiyama M.

    J Invest Dermatol   Vol. 137 ( 9 ) page: 2024-2026   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jid.2017.04.036.

  7. A Child with Epidermolytic Ichthyosis from a Parent with Epidermolytic Nevus: Risk Evaluation of Transmission from Mosaic to Germline

    Kono Michihiro, Suga Yasushi, Akashi Tomohiro, Ito Yasutomo, Takeichi Takuya, Muro Yoshinao, Akiyama Masashi

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   Vol. 137 ( 9 ) page: 2024-2026   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jid.2017.04.036

    Web of Science

    PubMed

  8. *Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases Reviewed

    Ban R, Matsuzaki H, Akashi T, Sakashita G, Taniguchi H, Park SY, Tanaka H, Furukawa K, Urano T.

    J Biol. Chem.   Vol. 284   page: 28367-28381   2009.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  9. PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha} Reviewed

    Suzuki M, Niimi A, Limsirichaikul S, Tomida S, Miao Huang Q, Izuta S, Usukura J, Itoh Y, Hishida T, Akashi T, Nakagawa Y, Kikuchi A, Pavlov Y, Murate T, Takahashi T.

    J. Biochem.   Vol. 146 ( 1 ) page: 13-21   2009.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  10. *Dynamic association of topoisomerase II to the mitotic chromosomes in live cells of Aspergillus nidulans. Reviewed

    Kawagishi M, Akashi T, Kikuchi A

    Biochemical Biophysical Research Communications   Vol. 334   page: 324-332   2005

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    Language:English   Publishing type:Research paper (scientific journal)  

  11. Centrosome as an organizing center of intracellular information: insights viewed from the spindle pole of budding yeast Invited

    Tomohiro Akashi

    Seikagaku   Vol. 77   page: 261-268   2005

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    Authorship:Lead author   Language:Japanese  

  12. *Gamma-tubulin in basal land plants: characterization, localization, and implication in the evolution of acentriolar microtubule organizing centers Reviewed

    Shimamura, M., Brown, R.C., Lemmon, B.E., Akashi, T., Mizuno, K., Nishihara, N., Tomizawa, K., Yoshimoto, K., Deguchi, H., Hosoya, H., Horio, T., and Mineyuki, Y.

    Plant Cell   Vol. 16   page: 45-59   2004

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    Language:English   Publishing type:Research paper (scientific journal)  

  13. *Involvement of nucleocytoplasmic shuttling of yeast Nap1 in mitotic progression. Reviewed

    Miyaji-Yamaguchi M, Kato K, Nakano R, Akashi T, Kikuchi A, Nagata K.

    Molecular Cellular Biology   Vol. 23   page: 6672-6684   2003

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    Language:English   Publishing type:Research paper (scientific journal)  

  14. Molecular and structural characterization of the spindle pole bodies in the fission yeast Schizosaccharomyces japonicus var. japonicus Reviewed

    Horio, T., Kimura, N., Basaki, A., Tanaka, Y., Noguchi, T., Akashi, T. and Tanaka, K.

    Yeast   Vol. 19   page: 1335-1350   2002

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    Language:English   Publishing type:Research paper (scientific journal)  

  15. Divergencies of gamma-tubulin and gamma-tubulin-related proteins Invited Reviewed

    Tomohiro Akashi

    Plant Morphology   Vol. 13   page: 21-30   2001

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    Authorship:Lead author   Language:Japanese  

  16. NBP1 (Nap1 binding protein 1), an essential gene for G2/M transition of Saccharomyces cerevisiae, encodes a protein of distinct sub-nuclear localization. Reviewed

    Shimizu Y, Akashi T, Okuda A, Kikuchi A, Fukui K.

    Gene   Vol. 246   page: 395-404   2000

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    Language:English   Publishing type:Research paper (scientific journal)  

  17. Involvement of the cytoskeleton in the intracellular distribution of mannoproteins in hyphal cells of Candida albicans

    Journal of Plant Research   Vol. 111   page: 531-540   1998

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    Language:English  

  18. Characterization of γ-tubulin complexes in Aspergillus nidulans and detection of putative γ-tubulin interacting proteins Reviewed

    Cell Motility and the Cytoskeleton   Vol. 37   page: 149-158   1997

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  19. Localized accumulation of cell wall mannoproteins and endomembranes induced by brefeldin A in hyphal cells of the dimorphic yeast Candida albicans Reviewed

    Protoplasma   Vol. 197   page: 45-56   1997

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  20. The role of cytoskeleton for induction and ongoing for germ tube growth of candida albicans

    Microbiology   Vol. 140   page: 271-280   1994

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    Language:English  

  21. Cytoskeleton in yeasts : dynamic behaviors in the cell cycle

    Protein, Nucleic acid and Enzyme   Vol. 39 ( 4 ) page: 373-382   1994

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    Language:English  

  22. Changes in the distribution of F-actin in the fission yeast Schizosaccharomyces pombe by arresting growth in distilled water : correlative studies with fluorescence and electron microscopy

    Journal of Electron Microscopy   Vol. 43   page: 20-24   1994

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    Language:English  

  23. Ultrastructure of proteinase secreting cells of candida albicans, studied by alkaline bismuth staining and immuno cytochemistry

    Journal of General Microbiology   Vol. 139   page: 2185-2195   1993

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    Language:English  

  24. Enhancement of extracapsular polysaccharide synthesis in Klebsiella pneumoniae by RmpA2, which shows homology to NtrC and FixJ

    Infection and Immunity   Vol. 61   page: 3164-3174   1993

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    Language:English  

  25. Effect of cytochalasin A on actin distribution in the fission yeast schizosaccharomyces pombe by fluorescent and electron microscopy

    Protoplasma   Vol. 176   page: 24-32   1993

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    Language:English  

  26. Involvement of transmembrane proteins in the association of cortical microtubules with the plasma membrane in tobacco BY-2 cells.

    Journal of Cell Science   Vol. 98   page: 169-174   1991

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    Language:English  

  27. Stabilization of cortical microtubules by the cell wall in cultured tobacco cells.

    Planta   Vol. 182   page: 363-369   1990

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    Language:English  

  28. Effects of propyzamide on tobacco cell microtubules in vivo and in vitro.

    Plant and Cell Physiology   Vol. 29   page: 1053-1062   1988

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    Language:English  

  29. Effects of gibberellin on the arrangement and the cold stability of cortical microtubules in epidermal cells of pea internodes.

    Plant and Cell Physiology   Vol. 28   page: 339-348   1987

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    Language:English  

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Research Project for Joint Research, Competitive Funding, etc. 1

  1. IMSによる土壌由来カビ検出データベースの構築

    2009.10 - 2012.3

    科学技術振興機構先端計測分析技術・機器開発事業 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. カビ代謝ペプチドの解析のためのフラグメンテーション理論の新展開

    2012.4 - 2015.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Coinvestigator(s) 

  2. 細胞の極性成長を支える多分子間相互作用ネットワークの解析

    2007

    科学研究費補助金  基盤研究(C),課題番号:19570181

    紅 朋浩

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    Authorship:Principal investigator 

 

Teaching Experience (On-campus) 19

  1. 病理病態学

    2020

  2. 生物学基礎I

    2020

  3. CIBoG Gene and genome analysis: Basics of NGS analysis

    2020

  4. 生体と微生物

    2020

  5. 真菌学実習

    2020

  6. Gene and genome analysis: yeast two hybrid system and NGS analysis

    2019

  7. 病理病態学

    2019

  8. 生物学基礎I

    2019

  9. 真菌学実習

    2019

  10. 生体と微生物

    2019

  11. Gene and genome analysis: yeast two hybrid system and NGS analysis

    2019

  12. Gene and genome analysis: yeast two hybrid system and NGS analysis

    2018

  13. Gene and genome analysis: yeast two hybrid system and NGS analysis

    2017

  14. Gene and genome analysis: yeast two hybrid system and NGS analysis

    2016

  15. Gene and genome analysis: yeast two hybrid system and NGS analysis

    2015

  16. Gene and genome analysis: yeast two hybrid system and NGS analysis

    2014

  17. Gene analyses with yeast

    2013

  18. 酵母two hybrid system

    2012

  19. 酵母two hybrid system

    2010

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Social Contribution 1

  1. スーパーサイエンスハイスクール

    2011.7